GenomeNet

Database: Pfam
Entry: Csm1_N
LinkDB: Csm1_N
Original site: Csm1_N 
#=GF ID   Csm1_N
#=GF AC   PF18504.2
#=GF DE   Csm1 N-terminal domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF05456
#=GF GA   26.30 26.30;
#=GF TC   26.30 28.80;
#=GF NC   26.10 26.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Coiled-coil
#=GF RN   [1]
#=GF RM   20723757
#=GF RT   The monopolin complex crosslinks kinetochore components to
#=GF RT   regulate chromosome-microtubule attachments.
#=GF RA   Corbett KD, Yip CK, Ee LS, Walz T, Amon A, Harrison SC;
#=GF RL   Cell. 2010;142:556-567.
#=GF DR   INTERPRO; IPR041671;
#=GF DR   SO; 0001080; coiled_coil;
#=GF CC   In the budding yeast Saccharomyces cerevisiae, sister chromatid
#=GF CC   co-orientation in meiosis I depends on the four-protein
#=GF CC   monopolin complex (Mam1, Csm1, Lrs4, and Hrr25/casein kinase 1),
#=GF CC   which localizes to centromeres from meiotic prophase through
#=GF CC   metaphase I. Csm1 and Lrs4, form a complex that resides in the
#=GF CC   nucleolus during interphase and relocalizes to centromeres
#=GF CC   during meiotic prophase, accompanied by phosphorylation of Lrs4.
#=GF CC   This is the N-terminal domain of Csm1 which forms a coiled-coil
#=GF CC   [1].
#=GF SQ   28
#=GS A0A1G4IMI5_9SACH/1-70   AC A0A1G4IMI5.1
#=GS H2B131_KAZAF/1-70       AC H2B131.1
#=GS A0A109V080_9SACH/1-70   AC A0A109V080.1
#=GS M1VGV8_CYAM1/345-410    AC M1VGV8.1
#=GS C5DC27_LACTC/1-70       AC C5DC27.1
#=GS J7S2J4_KAZNA/1-70       AC J7S2J4.1
#=GS I2H5E5_TETBL/2-71       AC I2H5E5.1
#=GS G0WFM8_NAUDC/4-73       AC G0WFM8.1
#=GS Q6FVN3_CANGA/1-70       AC Q6FVN3.1
#=GS Q6FVN3_CANGA/1-70       DR PDB; 6MJE A; 69-70;
#=GS Q6FVN3_CANGA/1-70       DR PDB; 6MJE C; 69-70;
#=GS Q6FVN3_CANGA/1-70       DR PDB; 6MJB B; 69-70;
#=GS Q6FVN3_CANGA/1-70       DR PDB; 6MJC A; 69-70;
#=GS Q6FVN3_CANGA/1-70       DR PDB; 6MJE E; 69-70;
#=GS Q6FVN3_CANGA/1-70       DR PDB; 6MJE G; 69-70;
#=GS A0A1G4ILN9_9SACH/1-70   AC A0A1G4ILN9.1
#=GS Q751E1_ASHGO/1-70       AC Q751E1.1
#=GS G8JQ87_ERECY/24-93      AC G8JQ87.1
#=GS G8C0R1_TETPH/2-71       AC G8C0R1.1
#=GS CSM1_YEAST/1-70         AC P25651.1
#=GS CSM1_YEAST/1-70         DR PDB; 5KTB A; 20-70;
#=GS CSM1_YEAST/1-70         DR PDB; 3N7N A; 3-70;
#=GS CSM1_YEAST/1-70         DR PDB; 3N4X B; 3-70;
#=GS CSM1_YEAST/1-70         DR PDB; 3N4X D; 3-70;
#=GS CSM1_YEAST/1-70         DR PDB; 3N4X C; 16-70;
#=GS CSM1_YEAST/1-70         DR PDB; 3N4R C; 69-70;
#=GS CSM1_YEAST/1-70         DR PDB; 3N4X A; 17-70;
#=GS CSM1_YEAST/1-70         DR PDB; 3N7N D; 3-70;
#=GS CSM1_YEAST/1-70         DR PDB; 3N4R D; 69-70;
#=GS CSM1_YEAST/1-70         DR PDB; 3N7N C; 8-70;
#=GS CSM1_YEAST/1-70         DR PDB; 3N7N B; 4-70;
#=GS CSM1_YEAST/1-70         DR PDB; 5KTB B; 13-70;
#=GS C5DWT0_ZYGRC/1-69       AC C5DWT0.1
#=GS Q6CKJ3_KLULA/1-70       AC Q6CKJ3.1
#=GS G8ZNB7_TORDC/1-70       AC G8ZNB7.1
#=GS A7TFZ2_VANPO/2-71       AC A7TFZ2.1
#=GS A0A1X7R5E9_9SACH/1-71   AC A0A1X7R5E9.1
#=GS A0A1E5R1G5_9ASCO/16-85  AC A0A1E5R1G5.1
#=GS A0A0N8WHG5_9FLAO/2-61   AC A0A0N8WHG5.1
#=GS S6E2A9_ZYGB2/1-69       AC S6E2A9.1
#=GS J5PIX1_SACK1/1-70       AC J5PIX1.1
#=GS G0VER7_NAUCC/1-70       AC G0VER7.1
#=GS A0A0C7N3D1_9SACH/1-70   AC A0A0C7N3D1.1
#=GS A0A1G4M994_LACFM/1-70   AC A0A1G4M994.1
#=GS A0A1G4JNI1_9SACH/1-70   AC A0A1G4JNI1.1
#=GS W0T7B3_KLUMD/1-70       AC W0T7B3.1
A0A1G4IMI5_9SACH/1-70              ....MDVLSQYKASIQSRLDSADVLVSKLVHENRMLAQESENKDDEIESLKRQLDVMKKRNEEFEKRASAAEEE.......
H2B131_KAZAF/1-70                  ....MEALIEYKESVKEQLENADLLITKLVNENSTLNEKLRVKDDRISNLENEIANLKQQVVKTQQQLKDKAEN.......
A0A109V080_9SACH/1-70              ....MDPLSRYKQAVQQRLDNADLAVSKIVRENTLLSQQVINKDEELQSLREEVKRLQQDAKREGERREKAGEE.......
M1VGV8_CYAM1/345-410               ..ra---FEEYRASVAVQLDAAERLVERYKSENEQLRQQLDH--AEVAKLRQRVDDLERTRTDQQLR-------ylelqk.
C5DC27_LACTC/1-70                  ....MDPISQYKAAVQSRLDNADILVSKLVHENRMLAQDVENKDQEIESLKRQLAAAEARSKECEERTGAAEEE.......
J7S2J4_KAZNA/1-70                  ....MNALQEYKDSVQERLNSADLLVSKAVHENSILTERLETQERELEALRKRVAELEVDCQGAKDDRNSSVED.......
I2H5E5_TETBL/2-71                  ....VDPLVEYKNSVEKRLNDAELLINRLIHENSVKDQLLEQRDEEISQLKATIEKLDEKSSSQLKKYDLSLEN.......
G0WFM8_NAUDC/4-73                  ....MDPLTTYKRSIQERLDAADVLVSKLTLENSLLNTAVDTHKQEVQSLKKQVKTLNEQLDGSKTSNEKQKET.......
Q6FVN3_CANGA/1-70                  ....MDPLSEYKKSVQKRLDAADLLVERVVQENTLLRQKLDSRDVELESVKEQLAVLRSKRDELDERSQKDKET.......
#=GR Q6FVN3_CANGA/1-70       SS    ....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXHH.......
A0A1G4ILN9_9SACH/1-70              ....MEPLVEYRKAVQERLNNADVLVAKLVHENGLAAQELENKQQELELLRSRLDERDDRLRQADKARAAAVEE.......
Q751E1_ASHGO/1-70                  ....MDPLSRYKQAVQQRLDSAERAVSKVVHENTVLAQQLATREKEVAALQAQVAEAEEARARAQTRQATLEEE.......
G8JQ87_ERECY/24-93                 ....MDPLSRYKHAVQQRLDNAELAVSKVVYENTLLSQQLSTKDQEIKRLREQVLELEEDGRQIDEKRRQLQEE.......
G8C0R1_TETPH/2-71                  ...a-NTLEQYKKLIGERLDNADLLVSKLVLENSLLKQQLESKDEQLKLLNGRLEHLAAQEQRHASALQDANE-a......
CSM1_YEAST/1-70                    ....MDPLTVYKNSVKQQIDSADLLVANLVNENFVLSEKLDTKATEIKQLQKQIDSLNAQVKELKTQTSQQAEN.......
#=GR CSM1_YEAST/1-70         SS    ....XXXHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.......
C5DWT0_ZYGRC/1-69                  ....MDALSQYRDSVKERLENADLLVSKLVHENTILEQSLEIRNQELESNRRRIRELEEQSKQSDESM------elvkd..
Q6CKJ3_KLULA/1-70                  ....MDPLAEYKESVQDRLEKADLAVQGVLNENVKLMRQLELKQQEIESLKEQLQSDKTKISQLEDSKADAEEQ.......
G8ZNB7_TORDC/1-70                  ....MDALTQYKRALQEQLESADLLIAKLVHENTVLSQTVETRTKKNQGLQERLQSVEERVKDLESRETKQEES.......
A7TFZ2_VANPO/2-71                  ...s-DSFIQYKKSIKERLDNADLLVSKVIHENTLLSQQLDSRNEEISYMKEKLDKHKTKVDSLNDKITKQNEN.......
A0A1X7R5E9_9SACH/1-71              ....MDTLVEYKKSVQKQLESNELLVAKLVHENTLLTQQLEGKTQQLELLQDELKKLKETRVSLQKELDTHQ--dev....
A0A1E5R1G5_9ASCO/16-85             ...n-DEIVQYKKLLNKRLEKSDLLINQLLLENEMLQKKLDTLSIQHAGLQQEYKQTCDKLVLIDEKLNEQED-n......
A0A0N8WHG5_9FLAO/2-61              stll------------NRIDQIELKVKALIIENQRLKKKLDSKQESIEGFKKQLEVAQEAIQEGN---------etivmlk
S6E2A9_ZYGB2/1-69                  ....MDALTQYKNSIQQRLDNADLLVAKLVHENTILGQTIELRNQALEASESQIKELKDRIKDLEESM------elvkd..
J5PIX1_SACK1/1-70                  ....MDPLTVYKNSLKQQIDSADLLVANLVNENFMLSEKLDAKSSEIKQLQKQIDSLNGQMTDLKTQVSHQTEN.......
G0VER7_NAUCC/1-70                  ....MDPLTQYKESVKEQSENAELLIAKLIHENSVLTTKNDTYSQEVETLRLQMAKLQEQLKVSEELRKKQAEN.......
A0A0C7N3D1_9SACH/1-70              ....MDPLVQYKASIQNRLDSADVLVSKLVHENRMLAQETENKDEEIKALKQQLESIKKRNEEDEKRANVAEEE.......
A0A1G4M994_LACFM/1-70              ....MDPLVEYKNSVQNRLDNADILVSRLVHENSLLSQEVENRDQEIETLKRQLETHKREEEERQHRMTSLEEE.......
A0A1G4JNI1_9SACH/1-70              ....MDALTQYKTSIQSRLDSADILVSKLIHENRMLSQELENKDEEMDSLKRQLELARKRNEEFDKKCSTAEEE.......
W0T7B3_KLUMD/1-70                  ....MDALAEYKESVQDRLDKADLAVQGVLNENVKLQRQLELKQQEIESLKEQLASERNRAETAESEKGDAEEQ.......
#=GC SS_cons                       ....XXXHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.......
#=GC seq_cons                      ....MDsLspYKpSVQpRLDsADLLVuKLVpENslLsQpL-s+spElcsL+cplcplccchcphccchsptpEp.......
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