GenomeNet

Database: Pfam
Entry: DAP10
LinkDB: DAP10
Original site: DAP10 
#=GF ID   DAP10
#=GF AC   PF07213.11
#=GF DE   DAP10 membrane protein
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_16910 (release 10.0)
#=GF GA   20.80 20.80;
#=GF TC   21.00 20.80;
#=GF NC   20.60 20.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12740576
#=GF RT   NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or
#=GF RT   Syk family kinases. 
#=GF RA   Zompi S, Hamerman JA, Ogasawara K, Schweighoffer E, Tybulewicz
#=GF RA   VL, Di Santo JP, Lanier LL, Colucci F; 
#=GF RL   Nat Immunol 2003;4:565-572.
#=GF DR   INTERPRO; IPR009861;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several mammalian DAP10 membrane
#=GF CC   proteins. In activated mouse natural killer (NK) cells, the
#=GF CC   NKG2D receptor associates with two intracellular adaptors, DAP10
#=GF CC   and DAP12, which trigger phosphatidyl inositol 3 kinase (PI3K)
#=GF CC   and Syk family protein tyrosine kinases, respectively. It has
#=GF CC   been suggested that the DAP10-PI3K pathway is sufficient to
#=GF CC   initiate NKG2D-mediated killing of target cells [1].
#=GF SQ   83
#=GS A0A2K5M660_CERAT/1-29     AC A0A2K5M660.1
#=GS A0A0A0MVN2_PAPAN/28-92    AC A0A0A0MVN2.1
#=GS G3RH41_GORGO/1-33         AC G3RH41.1
#=GS S7P548_MYOBR/109-170      AC S7P548.1
#=GS A0A1I8GUT4_9PLAT/4-71     AC A0A1I8GUT4.1
#=GS F6QB51_ORNAN/3-74         AC F6QB51.1
#=GS F1QIP7_DANRE/1-76         AC F1QIP7.1
#=GS G7PXB3_MACFA/28-92        AC G7PXB3.1
#=GS A0A0A0MVN2_PAPAN/1-29     AC A0A0A0MVN2.1
#=GS F7I7B3_CALJA/1-93         AC F7I7B3.1
#=GS H2NYI9_PONAB/1-93         AC H2NYI9.1
#=GS A0A1D5SZB9_WHEAT/261-324  AC A0A1D5SZB9.1
#=GS A0A1S3RYW7_SALSA/5-66     AC A0A1S3RYW7.1
#=GS A0A2K5I141_COLAP/1-29     AC A0A2K5I141.1
#=GS A0A2I4B8X8_9TELE/1-77     AC A0A2I4B8X8.1
#=GS G1PTM2_MYOLU/1-79         AC G1PTM2.1
#=GS G7PXB3_MACFA/1-29         AC G7PXB3.1
#=GS A0A1S3FYV3_DIPOR/1-80     AC A0A1S3FYV3.1
#=GS A0A1U7QVK2_MESAU/1-78     AC A0A1U7QVK2.1
#=GS G3NY72_GASAC/2-77         AC G3NY72.1
#=GS W9VKG2_9EURO/27-82        AC W9VKG2.1
#=GS A0A1S3WTL4_ERIEU/1-80     AC A0A1S3WTL4.1
#=GS HCST_MOUSE/1-79           AC Q9QUJ0.1
#=GS G1RLI6_NOMLE/1-33         AC G1RLI6.2
#=GS HCST_BOVIN/1-79           AC Q1XF11.1
#=GS Q45UD0_ICTPU/1-78         AC Q45UD0.1
#=GS HCST_HUMAN/1-33           AC Q9UBK5.1
#=GS HCST_MACMU/1-79           AC Q8WNQ9.1
#=GS I3MXL7_ICTTR/4-85         AC I3MXL7.1
#=GS TYOBP_RAT/7-84            AC Q6X9T7.1
#=GS A0A167RKJ0_9BASI/177-253  AC A0A167RKJ0.1
#=GS G3SKY3_LOXAF/1-80         AC G3SKY3.1
#=GS A0A1S3G0B0_DIPOR/1-80     AC A0A1S3G0B0.1
#=GS A0A2K5I141_COLAP/27-91    AC A0A2K5I141.1
#=GS A0A1A6HIT6_NEOLE/1-89     AC A0A1A6HIT6.1
#=GS HCST_PIG/1-79             AC Q9GJR5.1
#=GS A0A091DID3_FUKDA/5-82     AC A0A091DID3.1
#=GS G3RH41_GORGO/27-93        AC G3RH41.1
#=GS A0A1U7V291_TARSY/32-92    AC A0A1U7V291.1
#=GS W5M827_LEPOC/1-51         AC W5M827.1
#=GS G1RLI6_NOMLE/29-92        AC G1RLI6.2
#=GS F7I9M5_CALJA/1-28         AC F7I9M5.1
#=GS A0A287DCT7_ICTTR/1-77     AC A0A287DCT7.1
#=GS A0A2G9REK9_LITCT/1-62     AC A0A2G9REK9.1
#=GS A0A1U7UST9_TARSY/1-28     AC A0A1U7UST9.1
#=GS A0A287B894_PIG/1-79       AC A0A287B894.1
#=GS A0A2K5M660_CERAT/28-92    AC A0A2K5M660.1
#=GS A0A287CYL7_ICTTR/1-69     AC A0A287CYL7.1
#=GS A0A1I8HFX3_9PLAT/4-71     AC A0A1I8HFX3.1
#=GS G5BXP4_HETGA/5-82         AC G5BXP4.1
#=GS A0A0D9QW99_CHLSB/1-29     AC A0A0D9QW99.1
#=GS A0A0P7ULN7_9TELE/12-77    AC A0A0P7ULN7.1
#=GS A0A2I2USX6_FELCA/1-74     AC A0A2I2USX6.1
#=GS W5LBP5_ASTMX/4-78         AC W5LBP5.1
#=GS W5P531_SHEEP/1-79         AC W5P531.1
#=GS A0A096M3Q3_POEFO/4-81     AC A0A096M3Q3.1
#=GS R7EK58_9FIRM/15-60        AC R7EK58.1
#=GS I3J3R9_ORENI/7-81         AC I3J3R9.1
#=GS G3W8K8_SARHA/1-80         AC G3W8K8.1
#=GS M4A7K3_XIPMA/3-66         AC M4A7K3.1
#=GS A0A0D9QW99_CHLSB/26-92    AC A0A0D9QW99.1
#=GS J9P4D7_CANLF/6-73         AC J9P4D7.1
#=GS A0A1U7V291_TARSY/1-28     AC A0A1U7V291.1
#=GS F6RC81_HORSE/1-79         AC F6RC81.1
#=GS A0A1U7UST9_TARSY/32-91    AC A0A1U7UST9.1
#=GS F7EE63_ORNAN/2-72         AC F7EE63.1
#=GS A0A0K0VJM7_XENLA/6-84     AC A0A0K0VJM7.1
#=GS M2NAP8_BAUCO/137-202      AC M2NAP8.1
#=GS G1SQN9_RABIT/1-79         AC G1SQN9.1
#=GS A0A1S3NBE5_SALSA/6-80     AC A0A1S3NBE5.1
#=GS A0A1U7RM76_ALLSI/1-74     AC A0A1U7RM76.1
#=GS F7AQW3_MACMU/1-29         AC F7AQW3.1
#=GS HCST_HUMAN/27-93          AC Q9UBK5.1
#=GS F7I9M5_CALJA/31-92        AC F7I9M5.1
#=GS HCST_RAT/1-79             AC Q6X9T8.1
#=GS H2QG50_PANTR/1-33         AC H2QG50.2
#=GS H2QG50_PANTR/27-92        AC H2QG50.2
#=GS F7AQW3_MACMU/28-92        AC F7AQW3.1
#=GS A0A1E1KE72_9HELO/52-120   AC A0A1E1KE72.1
#=GS A0A151NDP4_ALLMI/20-79    AC A0A151NDP4.1
#=GS Q7ZZC1_XENLA/4-84         AC Q7ZZC1.2
#=GS A0A1U7QM63_MESAU/1-79     AC A0A1U7QM63.1
#=GS A0A287B1P0_PIG/10-63      AC A0A287B1P0.1
A0A2K5M660_CERAT/1-29                ................MIHPGHILFLL.L...LPVAA.....A.Q..............TTP..............GE..RS-------------.---------------.-.----..-..------.-..........------------lla................
A0A0A0MVN2_PAPAN/28-92               ..........lafypg-----------.-...-----.....-.-..............-TS..............GS..CSGCGSLSLPLLAGL.VAADAVASLLIVGAV.F.LCAR..P..RRSPAQ.E..........DGKVYINMPGRG...................
G3RH41_GORGO/1-33                    ................MIHLGHILFLL.L...LPVAA.....A.Q..............TTP..............GE..RS-------------.---------------.-.----..-..------.-..........------------slpafyp............
S7P548_MYOBR/109-170                 .........pfcfglh-----------.-...-----.....-.-..............-PP..............GS..YSGCGPLPLPLLAGL.VAADAVVSLLIVVVV.F.MCAS..P..RDRPTQ.G..........EGRAW-------tgg................
A0A1I8GUT4_9PLAT/4-71                .....ndgqsqgsgsa-----------.-...-----.....-.-..............---..............-T..DSGVGLANLAIYIGL.VAAAAVVVIIVLVIV.Y.FVRR..K..SA----.-..........------------tfgsnrqglrynvhmngq.
F6QB51_ORNAN/3-74                    ..............mk---PGSSLLGL.LlalLGNVR.....G.Q..............SQN..............-G..CSGCYPVTPGVLAGI.ILGDLALTLFIALAV.Y.YLAR..M..VARPR-.-..........------------gtagaa.............
F1QIP7_DANRE/1-76                    ................MTKKGLLVFLL.S...LIVMV.....-.-..............RAD..............GD..KYSCFGVSSGTVAGI.IFADVAVTVLIVTTT.Y.WYAS..K..RRQKKE.N..........ADEVYMNV----ran................
G7PXB3_MACFA/28-92                   ..........lafypg-----------.-...-----.....-.-..............-TS..............GS..CSGCGSLSLPLLAGL.VAADAVASLLIVGAV.F.LCAR..P..RRSPAQ.E..........DGKVYINMPGRG...................
A0A0A0MVN2_PAPAN/1-29                ................MIHPGHILFLL.L...LPVAA.....A.Q..............TTP..............GE..RS-------------.---------------.-.----..-..------.-..........------------lla................
F7I7B3_CALJA/1-93                    ................MVLLGHILFLL.L...LPVAK.....T.QpqnaepelsprpgpHSP..............GS..CSGCGPLSLPLLAGL.VAADAVVSLLIVGAV.F.LCAR..P..RRSPAQ.E..........DGKVYINMPGRG...................
H2NYI9_PONAB/1-93                    ................MIHPGHILFLL.L...LPVAA.....A.Q..............TTPgersslpafhpgtsGS..CSGCGSLSLPLLAGL.VAADAVASLLIVGAV.F.LCAR..P..RRSPPQ.E..........DGKVYINMPGRG...................
A0A1D5SZB9_WHEAT/261-324             .....stlptrnytal-----------.-...-----.....-.-..............---..............PS..TSSTKKATLPLIAGV.AAAAVVALLLAVTVA.V.LLRR..A..SRRNRQ.T..........DDK---------dmlag..............
A0A1S3RYW7_SALSA/5-66                .....lcimvpvkgmf-----------.-...-----.....-.-..............---..............-D..CGQCYQIDMGELVGI.IACDIILTLLIALAV.F.CFAS..L..RKKRSQ.Q..........ESR---------legk...............
A0A2K5I141_COLAP/1-29                ................MIHPGHILFLL.L...LPAAA.....A.Q..............TTP..............GE..RS-------------.---------------.-.----..-..------.-..........------------lpa................
A0A2I4B8X8_9TELE/1-77                .....masakllvlvl---------FF.L...CNLPE.....A.L..............TDS..............AS..CYRIEPWT---IAII.VSADLVLTLIIVAVT.Y.RCAS..F..RRRKID.N..........ANKVYMNV----ran................
G1PTM2_MYOLU/1-79                    ................MLPPGNILLLL.L...LPVAA.....A.Q..............VTP..............GS..YSGCGPLPLPLLAGL.VAADAVVSLLIVVVV.F.MCAS..P..RDRPTQ.E..........DGKVYINMPGRG...................
G7PXB3_MACFA/1-29                    ................MIHPGHILFLL.L...LPVAA.....A.Q..............TTP..............GE..RS-------------.---------------.-.----..-..------.-..........------------lla................
A0A1S3FYV3_DIPOR/1-80                ................MVYRGYFLLLF.L...LPVAA.....A.Q..............TPS..............GS..CSGCGPLSLPLLASL.VAAEAAMSLIMVGVV.F.ACAR..S.pRRGSPQ.G..........DGTVYINMPSRG...................
A0A1U7QVK2_MESAU/1-78                ................MTPPSHLLFLL.L...LPVAA.....S.Q..............TPA..............GP..CSGCGPLSLPLLAGL.VAADAVLSLLIVGVV.F.VCMR..P..HSRLAQ.-..........DSRVYINMPGRG...................
G3NY72_GASAC/2-77                    .........gynkffi---------VL.M...FLCNA.....A.V..............ALP..............ES..TVSCYRIEPGTXAGI.VCADVLLTLVIVVVT.Y.RCAG..Y..RRQKIE.K..........ADEVYMNV----ran................
W9VKG2_9EURO/27-82                   ..........lggddg-----------.-...-----.....-.-..............-TA..............SS..PSSSGPLSTGTIVGI.VTGSVVAAAGIVGAV.F.KCLS..Y..RHKKKQ.-..........------------asli...............
A0A1S3WTL4_ERIEU/1-80                ................MVPSGNLLLLL.L...LPAAA.....A.Q..............SAP..............GS..CSGCGSLSPLLLASL.VAVDALVSLLIVLVV.F.VRTC..P..GVETTQ.E..........EGKIYINMPG--grg................
HCST_MOUSE/1-79                      ................MDPPGYLLFLL.L...LPVAA.....S.Q..............TSA..............GS..CSGCGTLSLPLLAGL.VAADAVMSLLIVGVV.F.VCMR..P..HGRPAQ.E..........DGRVYINMPGRG...................
G1RLI6_NOMLE/1-33                    ................MTHPGHILFLL.L...LPVAA.....T.Q..............TTP..............GE..RSS------------.---------------.-.----..-..------.-..........------------vpafyp.............
HCST_BOVIN/1-79                      ................MVPPGNILFLL.L...LPVAT.....A.Q..............MTP..............GS..CSGCGPLSLPLLAGL.VAADAVVSLLIVVVV.F.VCAR..L..RSRPTQ.E..........DDKIYINMPGRG...................
Q45UD0_ICTPU/1-78                    ........mtnqgfpl-----YLFFSC.L...AMISA.....E.E..............TEK..............GS..CYRI---APGMLAGV.VLGDIALTILIVAAT.Y.YCAS..K..RRIKKE.K..........ADKVYMNV----ran................
HCST_HUMAN/1-33                      ................MIHLGHILFLL.L...LPVAA.....A.Q..............TTP..............GE..RS-------------.---------------.-.----..-..------.-..........------------slpafyp............
HCST_MACMU/1-79                      ................MIHPGHILFLL.L...LPVAA.....A.Q..............TTP..............GS..CSGCGSLSLPLLAGL.VAADAVASPLIVGAV.F.LCAR..P..RRSPAQ.G..........DGKVYINMPGRG...................
I3MXL7_ICTTR/4-85                    ...........ldpsw-----RLLVLL.L...LTVAGlspvqA.Q..............NAI..............FP..ECNCSPVSAGVLAGI.VLGDLVLTLLIALAV.Y.SLGR..L..V-----.-..........------------prgrgtaagtqkqhit...
TYOBP_RAT/7-84                       .swcflflpvlltvgg-----------.L...SPVQA.....Q.S..............DNY..............-P..GCECSSVSPGVLAGI.VLGDLVLTLLIALAV.Y.SLGR..L..VSRG--.-..........------------rgtadgtrkqh........
A0A167RKJ0_9BASI/177-253             ......lpgatstmsv-----------.-...VPASS.....GgD..............SEY..............GS..SSG-STLSHSQIAGI.VVGAVAAMALVVLVI.A.LCMR..S..RSRPTS.-..........------------fsaeavppapgpg......
G3SKY3_LOXAF/1-80                    ................MTPPGRILLLLmL...FPVAA.....A.Q..............TAP..............CT..CWGCGPLSLPLLVGL.VAADAVLSLLIVGVV.F.MCAR..P..RHQPTQ.E..........VDKVYINMPVRG...................
A0A1S3G0B0_DIPOR/1-80                ................MVYRGYFLLLF.L...LPVAA.....A.Q..............TSP..............GS..CSGCGPLSLPLLASL.VAAEAAMSLIMVGVV.F.ACAR..S.pRRGSPQ.G..........DGTVYINMPSRG...................
A0A2K5I141_COLAP/27-91               .........lpafypg-----------.-...-----.....-.-..............-TS..............GS..CSGCGSLSLPLLAGL.VAADAVASLLIVGAV.F.LCAR..P..RRSPAQ.E..........-GKVYINMPGRG...................
A0A1A6HIT6_NEOLE/1-89                ................MTPPGHLLFLL.L...LPVAA.....S.Q..............TPA..............GS..CSGCGPLSLPLLAGL.VAADAVLSLLIVGVV.F.VCMR..P..HSRPAQ.GeqtlgrglakDSRVYINMPGR-s..................
HCST_PIG/1-79                        ................MAPPGGILFLL.L...LPVAA.....A.Q..............VTS..............GS..CSGCGPLSLPLLAGL.VAADAVVSLLIVVGV.F.VCGR..P..RSRPTQ.E..........DGKIYINMPGRG...................
A0A091DID3_FUKDA/5-82                ..........epfwql------LLLPL.L...LTVAG....vS.P..............VQA..............QS..GCNCTPMSAGVLAGI.VLGDLVLTLLIALAV.Y.SLGR..L..VP----.-..........------------rgrktaqmarkqpit....
G3RH41_GORGO/27-93                   ........slpafypg-----------.-...-----.....-.-..............-TS..............GS..CSGCGSLSLPLLAGL.VAADAVASLLIVGAV.F.LCAR..P..RRSPAQ.E..........DGKVYINMPGRG...................
A0A1U7V291_TARSY/32-92               .............pga-----------.-...-----.....-.-..............--S..............GS..CSGCGPLSLPLLAGL.VAADAFVSLLIVGAV.F.LCAR..P..RHRPTQ.E..........DGKVYINMPGRG...................
W5M827_LEPOC/1-51                    ........cykiepgt-----------.-...-----.....-.-..............---..............--..-----------MVGI.IAGDVVLTVLIVISV.Y.YCAS..R..KRHKRE.Q..........ADKVYMNV----ran................
G1RLI6_NOMLE/29-92                   ..........pafypg-----------.-...-----.....-.-..............-TS..............GS..CSGCGSLSLPLLAGL.VAADAVASLLIVGAV.F.LCAR..P..RRSPAQ.-..........DGKVYINMPGRG...................
F7I9M5_CALJA/1-28                    ................MVLLGHILFLL.L...LPGGA.....A.Q..............TTP..............GE..RS-------------.---------------.-.----..-..------.-..........------------ll.................
A0A287DCT7_ICTTR/1-77                ................MTPPGHILLLL.L...LPAAA.....A.Q..............MST..............GS..CSGCGPLSPLLLVGL.VAADAIMSLIIVGVV.L.VCAR..P..RR--PQ.E..........NDKIYINVPGRG...................
A0A2G9REK9_LITCT/1-62                ..............cf-----------.-...-----.....-.-..............-AE..............SS..CGDCYHIDTTTLISV.VVGDVFLTVVIILVV.Y.YCTK..QsfQRKDKD.D..........DRKVYMNMPIR-...................
A0A1U7UST9_TARSY/1-28                ................MVPPGHILLLL.L...LPVAA.....A.Q..............TTP..............GE..RS-------------.---------------.-.----..-..------.-..........------------lh.................
A0A287B894_PIG/1-79                  ................MAPPGGILFLL.L...LPGEA.....S.P..............NPS..............GS..CSGCGPLSLPLLAGL.VAADAVVSLLIVVGV.F.VCGR..P..RSRPTQ.E..........DGKIYINMPGRG...................
A0A2K5M660_CERAT/28-92               ..........lafypg-----------.-...-----.....-.-..............-TS..............GS..CSGCGSLSLPLLAGL.VAADAVASLLIVGAV.F.LCAR..P..RRSPAQ.E..........DGKVYINMPGRG...................
A0A287CYL7_ICTTR/1-69                ................MTPPGHILLLL.L...LP---.....-.-..............---..............GS..CSGCGPLSPLLLVGL.VAADAIMSLIIVGVV.L.VCAR..P..RR--PQ.E..........NDKIYINVPGRG...................
A0A1I8HFX3_9PLAT/4-71                .....ndgqsqgsgsa-----------.-...-----.....-.-..............---..............-T..DSGVGLANLAIYIGL.VAAAAVVVIIVLVIV.Y.FVRR..K..S-----.-..........------------atfgsnrrglrynvhmngn
G5BXP4_HETGA/5-82                    ..........epswrl------LLLPL.L...LTVAG....vS.P..............VQA..............QS..GCNCAPVSAGVLAGI.VLGDLVLTLLIALAV.Y.SLGR..L..VP----.-..........------------rgrktaqmtrkqpit....
A0A0D9QW99_CHLSB/1-29                ................MIHPGHILFLL.L...LPVAA.....A.Q..............MTP..............GE..RS-------------.---------------.-.----..-..------.-..........------------lpa................
A0A0P7ULN7_9TELE/12-77               ..............er---------LL.L...LASDT.....Q.R..............LGP..............SSeaCDNCVALESSTVAGI.VSADIVATVLIGVAVyF.IASQ..P..RGR---.-..........------------sysnskg............
A0A2I2USX6_FELCA/1-74                ................MAPSSDILFLL.L...LPGEA.....S.-..............---..............GS..CSGCGPPSLPMLVGL.MAADLVVSLLIIAVV.F.VCAC..P..RRRPTQ.G..........EGR---------drmgpggg...........
W5LBP5_ASTMX/4-78                    ylfffwhknlsftsvf-----------.-...-----.....-.-..............-SV..............SD..CGSCYQINMGLVIGI.VTCDIIVTLLIAVAV.Y.CFAT..R..QKKKSR.L..........HTRANSCDPG--kg.................
W5P531_SHEEP/1-79                    ................MVLPGNILFLL.L...LPVAT.....A.Q..............MTP..............GS..CSGCGPLSLPLLAGL.VAADAVVSLLIVVVV.F.VCAR..L..RSRPTQ.E..........DDKIYINMPGRG...................
A0A096M3Q3_POEFO/4-81                ...........adnft-----TLLFLL.S...SNFSV.....C.L..............RSP..............DS..NVSCYRIEPGTIAGI.IAADLLLTLIIVVVT.Y.RCAS..F..RRQQID.N..........ADKVYMNV----ran................
R7EK58_9FIRM/15-60                   ........dvlcagdd-----------.-...-----.....-.-..............---..............--..-----------LNGL.VAADVKVAYLKVIAV.F.VAAK..P..HDAPD-.-..........------------lnvqyiva...........
I3J3R9_ORENI/7-81                    .........kfltvvl--------FGL.F...FSLAP.....A.-..............-LA..............DS..TVSCYRIEPGTIAGI.ICADVVLTLIIVVVT.Y.RCAS..F..RRQKID.N..........AHKVYMNV----ran................
G3W8K8_SARHA/1-80                    ................MNPWGASLLLA.L...LSVAA.....A.Q..............MPS..............VP..DPPCGPLSLPLLVGL.VAADALVTLLIVGVV.F.ACAR..P..RRAARKpE..........KSRVYVNMPGR-n..................
M4A7K3_XIPMA/3-66                    .......fsvclrlpd-----------.-...-----.....-.-..............---..............-S..NVSCYRIEPGTIAGV.IAADLLLTLIIVVVT.Y.RCAS..F..RRQKLF.T..........ADKVYMNV----ran................
A0A0D9QW99_CHLSB/26-92               ........slpafypg-----------.-...-----.....-.-..............-TS..............GS..CSGCGSLSLPLLAGL.VAADAVASLLIVGAV.F.LCAR..P..RRSPAQ.E..........DGRVYINMPGRG...................
J9P4D7_CANLF/6-73                    .......stafspgph-----------.-...-----.....-.-..............-PP..............GS..CSGCEPVCLPLLAGL.MAAHAVVSLLIIAAV.F.VCAC..P..RHRPTQ.E..........HDKIYINMPGRG...................
A0A1U7V291_TARSY/1-28                ................MVPPGHILLLL.L...LPVAA.....A.Q..............TTP..............GE..RS-------------.---------------.-.----..-..------.-..........------------lh.................
F6RC81_HORSE/1-79                    ................MASPDNVLFLL.L...LPVAA.....A.Q..............ITA..............GS..CSGCGPLSLPLLAGL.VAADAVVSLLIVAVV.F.VCMR..P..RSRPTQ.E..........DGKIYINMPARG...................
A0A1U7UST9_TARSY/32-91               .............pga-----------.-...-----.....-.-..............--S..............GS..CSGCGPLSLPLLAGL.VAADAFVSLLIVGAV.F.LCAR..P..RHRPTQ.-..........DGKVYINMPGRG...................
F7EE63_ORNAN/2-72                    ...............m--KPGSPLLGL.L...LAMFGn...vR.G..............QSQ..............NA..CSGCYPVTPGVLAGI.ILGDLTLTLLIALAV.Y.YLAR..M..VSRPQ-.-..........------------gaaga..............
A0A0K0VJM7_XENLA/6-84                .............ysm-----HLVILC.L...LAACA.....A.S..............SES..............EE..CKDCYRIDTATLVGV.VLGDILLTVIIILVV.Y.FCTK..QtfQKRITV.D..........DQKIYINMPM--kk.................
M2NAP8_BAUCO/137-202                 ..........psawts-----------.-...--IAV.....S.S..............DDD..............GD..SDGNGGLSVGAEAGIgVAAGVVALCLIGGVV.F.CLIR..R..KRRPAH.D..........N-----------rdrtw..............
G1SQN9_RABIT/1-79                    ................MVPPGHILLLL.F...LPVAA.....A.Q..............TPP..............GS..CSGCGPLSLPLLAGL.VAADAVVSLLVVGVV.F.ACAR..P..RHRPTQ.E..........DGKIYMNMPGRG...................
A0A1S3NBE5_SALSA/6-80                ..allmvlffclcekv-----------.-...--VAD.....P.G..............TNN..............PS..CYRIEP---GTMAGI.IVADMILTIAIVIVT.Y.HCAS..R..RRRRKE.R..........ADKVYMNV----ran................
A0A1U7RM76_ALLSI/1-74                ................MEPPEHALLGA.L...LAWALl...gS.V..............QGQ..............QG..CGGCPALGGGALAGL.VLGDLVLTLLIALAV.Y.CLAT..R..CRLPS-.-..........------------ssgdvkk............
F7AQW3_MACMU/1-29                    ................MIHPGHILFLL.L...LPVAA.....A.Q..............TTP..............GE..RS-------------.---------------.-.----..-..------.-..........------------lla................
HCST_HUMAN/27-93                     ........slpafypg-----------.-...-----.....-.-..............-TS..............GS..CSGCGSLSLPLLAGL.VAADAVASLLIVGAV.F.LCAR..P..RRSPAQ.E..........DGKVYINMPGRG...................
F7I9M5_CALJA/31-92                   .............ypg-----------.-...-----.....-.-..............-TS..............GS..CSGCGPLSLPLLAGL.VAADAVVSLLIVGAV.F.LCAR..P..RRSPAQ.E..........DGKVYINMPGRG...................
HCST_RAT/1-79                        ................MAPPGHLLFLF.L...LPVAA.....S.Q..............TNE..............GS..CSGCGPLSLPLLAGL.VAADAVMSLLIVGVV.F.VCMR..L..HSRPAQ.E..........DGRVYINMPGRG...................
H2QG50_PANTR/1-33                    ................MIHLGHILFLL.L...LPVAA.....A.Q..............TTP..............GE..RS-------------.---------------.-.----..-..------.-..........------------slpafyp............
H2QG50_PANTR/27-92                   ........slpafypg-----------.-...-----.....-.-..............-TS..............GS..CSGCGSLSLPLLAGL.VAADAVASLLIVGAV.F.LCTR..P..RRSPAQ.-..........DGKVYINMPGRG...................
F7AQW3_MACMU/28-92                   ..........lafypg-----------.-...-----.....-.-..............-TS..............GS..CSGCGSLSLPLLAGL.VAADAVASLLIVGVV.F.LCAR..P..RRSPAQ.E..........DGKVYINMPGRG...................
A0A1E1KE72_9HELO/52-120              ........sptttspp-----------.-...-----.....-.S..............TTS..............TS..CSGSGGLSAGAKAGI.GAGVAVVALIALLIL.N.FCLV..E..RRKRA-.-..........------------sqlpstsdpkyeiy.....
A0A151NDP4_ALLMI/20-79               .........almsske-----------.-...-----.....-.-..............REP..............RC..CGGCPALGGGALAGL.VLGDLVLTLLIALAV.YcLATR..C..RPPPSS.G..........DV----------kk.................
Q7ZZC1_XENLA/4-84                    ..............em--RPVHFVILC.L...LAACA.....E.S..............SES..............EG..CKDCYRIDTATLVGV.VVGDILLTVIIILVV.Y.YCTKrtF..QKRNSV.D..........NQKIYINMPM--kk.................
A0A1U7QM63_MESAU/1-79                ................MTPPSHLLFLL.L...LPVAA.....S.Q..............TPA..............GP..CSGCGPLSLPLLAGL.VAADAVLSLLIVGVV.F.VCMR..P..HSRLAQ.E..........DSRVYINMPGRG...................
A0A287B1P0_PIG/10-63                 .viplkmsqgdlsvaq-----------.-...-----.....-.-..............-AR..............SS..CSGCGPLSLPLLAGL.VAADAVVSLLIVVGV.F.VCGR..-..------.-..........------------...................
#=GC seq_cons                        ..........................h.h...hshts.....t.................ss..............GS..CSuCsslshshLAGl.VuADslhoLLIVssV.a.hCu+.....+pp.tp.t..........tsch...........................
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