GenomeNet

Database: Pfam
Entry: DARPP-32
LinkDB: DARPP-32
Original site: DARPP-32 
#=GF ID   DARPP-32
#=GF AC   PF05395.13
#=GF DE   Protein phosphatase inhibitor 1/DARPP-32
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   DOMO:DM07433;
#=GF GA   24.60 24.60;
#=GF TC   25.10 25.10;
#=GF NC   24.30 24.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10960791
#=GF RT   Expression and genomic characterization of protein phosphatase
#=GF RT   inhibitor-1: a novel marker for mesothelium in the mouse. 
#=GF RA   McLaren L, Boyle S, Mason JO, Bard JB; 
#=GF RL   Mech Dev 2000;96:237-241.
#=GF RN   [2]
#=GF RM   12543476
#=GF RT   Dopamine and cyclic AMP-regulated phosphoprotein immunoreactive
#=GF RT   neurons are innervated by axon terminals immunopositive for
#=GF RT   vasoactive intestinal polypeptide in the bed nuclei of the stria
#=GF RT   terminalis and central nucleus of the amygdala. 
#=GF RA   Kozicz T; 
#=GF RL   Brain Res 2003;962:237-243.
#=GF RN   [3]
#=GF RM   12546831
#=GF RT   Do all paths lead to DARPP-32? 
#=GF RA   Foubister V; 
#=GF RL   Drug Discov Today 2002;7:1068-1070.
#=GF RN   [4]
#=GF RM   12124342
#=GF RT   Gastric cancers overexpress DARPP-32 and a novel isoform,
#=GF RT   t-DARPP. 
#=GF RA   El-Rifai W, Smith MF Jr, Li G, Beckler A, Carl VS, Montgomery E,
#=GF RA   Knuutila S, Moskaluk CA, Frierson HF Jr, Powell SM; 
#=GF RL   Cancer Res 2002;62:4061-4064.
#=GF DR   INTERPRO; IPR008466;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several mammalian protein phosphatase
#=GF CC   inhibitor 1 (IPP-1) and dopamine- and cAMP-regulated neuronal
#=GF CC   phosphoprotein (DARPP-32) proteins. Protein phosphatase
#=GF CC   inhibitor-1 is involved in signal transduction and is an
#=GF CC   endogenous inhibitor of protein phosphatase-1 [1]. It has been
#=GF CC   demonstrated that DARPP-32, if phosphorylated, can inhibit
#=GF CC   protein-phosphatase-1 [2]. DARPP-32 has a key role in many
#=GF CC   neurotransmitter pathways throughout the brain and has been
#=GF CC   shown to be involved in controlling receptors, ion channels and
#=GF CC   other physiological factors including the brain's response to
#=GF CC   drugs of abuse, such as cocaine, opiates and nicotine. DARPP-32
#=GF CC   is reciprocally regulated by the two neurotransmitters that are
#=GF CC   most often implicated in schizophrenia - dopamine and glutamate.
#=GF CC   Dopamine activates DARPP-32 through the D1 receptor pathway and
#=GF CC   disables DARPP-32 through the D2 receptor. Glutamate, acting
#=GF CC   through the N-methyl-d-aspartate receptor, renders DARPP-32
#=GF CC   inactive [3]. A mutant form of DARPP-32 has been linked with
#=GF CC   gastric cancers [4].
#=GF SQ   652
#=GS A0A2I3S2W6_PANTR/2-183      AC A0A2I3S2W6.1
#=GS A0A2U4B1F4_TURTR/2-109      AC A0A2U4B1F4.1
#=GS A0A3Q3MNT7_9TELE/17-184     AC A0A3Q3MNT7.1
#=GS F1RWM4_PIG/2-181            AC F1RWM4.2
#=GS F6WW39_XENTR/17-186         AC F6WW39.1
#=GS F7H8B4_MACMU/3-166          AC F7H8B4.1
#=GS A0A3B4Y2T8_SERLL/16-177     AC A0A3B4Y2T8.1
#=GS A0A3B4WU40_SERLL/2-208      AC A0A3B4WU40.1
#=GS A0A218U8B9_9PASE/2-83       AC A0A218U8B9.1
#=GS A0A3B3R5Y1_9TELE/3-69       AC A0A3B3R5Y1.1
#=GS A0A151LZT7_ALLMI/2-87       AC A0A151LZT7.1
#=GS A0A2U3XBC5_LEPWE/3-72       AC A0A2U3XBC5.1
#=GS G3TG76_LOXAF/1-164          AC G3TG76.1
#=GS A0A091GDU4_9AVES/2-108      AC A0A091GDU4.1
#=GS F7CUX6_XENTR/80-258         AC F7CUX6.1
#=GS A0A3Q3E8K7_9LABR/2-68       AC A0A3Q3E8K7.1
#=GS A0A0Q3P9Q4_AMAAE/2-82       AC A0A0Q3P9Q4.1
#=GS A0A1U7SZY2_TARSY/2-61       AC A0A1U7SZY2.1
#=GS A0A2K5JVY1_COLAP/2-181      AC A0A2K5JVY1.1
#=GS L9JXD8_TUPCH/1-47           AC L9JXD8.1
#=GS A0A384BXZ3_URSMA/1-149      AC A0A384BXZ3.1
#=GS A0A2I4CE69_9TELE/11-151     AC A0A2I4CE69.1
#=GS A0A151P5C0_ALLMI/2-217      AC A0A151P5C0.1
#=GS I3LX65_ICTTR/2-192          AC I3LX65.2
#=GS A0A1L8EKM5_XENLA/2-182      AC A0A1L8EKM5.1
#=GS A0A3P8P3P3_ASTCA/6-163      AC A0A3P8P3P3.1
#=GS A0A2K5VVQ3_MACFA/47-167     AC A0A2K5VVQ3.1
#=GS A0A2R8P1L6_CALJA/2-175      AC A0A2R8P1L6.1
#=GS G5BRW9_HETGA/109-273        AC G5BRW9.1
#=GS PPR1A_HUMAN/3-166           AC Q13522.2
#=GS A0A3B5QZ22_XIPMA/2-204      AC A0A3B5QZ22.1
#=GS A0A2K5JW04_COLAP/2-48       AC A0A2K5JW04.1
#=GS A0A2U4CAU6_TURTR/6-146      AC A0A2U4CAU6.1
#=GS F7E107_HORSE/2-194          AC F7E107.2
#=GS A0A3P8WKU4_CYNSE/2-163      AC A0A3P8WKU4.1
#=GS G1LU56_AILME/1-174          AC G1LU56.1
#=GS A0A3P8XMF1_ESOLU/5-175      AC A0A3P8XMF1.1
#=GS A0A2R8NCU4_CALJA/2-48       AC A0A2R8NCU4.1
#=GS A0A3P8NDF8_ASTCA/12-173     AC A0A3P8NDF8.1
#=GS A0A3B4FUV2_9CICH/2-48       AC A0A3B4FUV2.1
#=GS A0A3Q3A6C1_CHICK/2-86       AC A0A3Q3A6C1.1
#=GS A0A286XET9_CAVPO/3-180      AC A0A286XET9.1
#=GS A0A401T7W0_CHIPU/2-171      AC A0A401T7W0.1
#=GS W5N4Y6_LEPOC/11-195         AC W5N4Y6.1
#=GS A0A2K5PV59_CEBCA/2-48       AC A0A2K5PV59.1
#=GS A0A2Y9K144_ENHLU/2-193      AC A0A2Y9K144.1
#=GS A0A2I3FX25_NOMLE/10-154     AC A0A2I3FX25.1
#=GS A0A2I2UJI1_FELCA/2-109      AC A0A2I2UJI1.1
#=GS A0A093HRB4_STRCA/2-97       AC A0A093HRB4.1
#=GS A0A384AST0_BALAS/2-116      AC A0A384AST0.1
#=GS A0A3B3DTJ1_ORYME/2-209      AC A0A3B3DTJ1.1
#=GS A0A3Q4BGG2_MOLML/11-140     AC A0A3Q4BGG2.1
#=GS F1QIS9_DANRE/2-171          AC F1QIS9.1
#=GS A0A2K5QUF2_CEBCA/3-167      AC A0A2K5QUF2.1
#=GS A0A3P9CFE0_9CICH/12-132     AC A0A3P9CFE0.1
#=GS G3WUW1_SARHA/2-109          AC G3WUW1.1
#=GS W5N4Y1_LEPOC/11-194         AC W5N4Y1.1
#=GS A0A3P8ZGK6_ESOLU/2-64       AC A0A3P8ZGK6.1
#=GS I7G6I7_MACFA/3-166          AC I7G6I7.1
#=GS A0A3P9BEU5_9CICH/2-208      AC A0A3P9BEU5.1
#=GS A0A2Y9JDV0_ENHLU/2-109      AC A0A2Y9JDV0.1
#=GS A0A3B3U9C8_9TELE/2-206      AC A0A3B3U9C8.1
#=GS A0A151P5A9_ALLMI/2-195      AC A0A151P5A9.1
#=GS A0A3B4GBI0_9CICH/2-146      AC A0A3B4GBI0.1
#=GS A0A2I4AVR5_9TELE/2-202      AC A0A2I4AVR5.1
#=GS A0A2U3XBC4_LEPWE/81-158     AC A0A2U3XBC4.1
#=GS A0A3Q1EE84_9TELE/2-161      AC A0A3Q1EE84.1
#=GS A0A1V4JQX4_PATFA/2-206      AC A0A1V4JQX4.1
#=GS A0A2R9A0B2_PANPA/23-123     AC A0A2R9A0B2.1
#=GS F7HE42_MACMU/47-167         AC F7HE42.2
#=GS A0A2K5C493_AOTNA/2-48       AC A0A2K5C493.1
#=GS A0A2U9CDB9_SCOMX/207-269    AC A0A2U9CDB9.1
#=GS G1S798_NOMLE/1-61           AC G1S798.3
#=GS A0A2I3MIL9_PAPAN/2-181      AC A0A2I3MIL9.1
#=GS A0A3B5B8N7_9TELE/2-51       AC A0A3B5B8N7.1
#=GS A0A1L8ERY7_XENLA/2-171      AC A0A1L8ERY7.1
#=GS A0A3Q7W6K2_URSAR/1-149      AC A0A3Q7W6K2.1
#=GS A0A2Y9LX00_DELLE/2-192      AC A0A2Y9LX00.1
#=GS F6RH66_MACMU/2-109          AC F6RH66.2
#=GS G3H5X5_CRIGR/47-148         AC G3H5X5.1
#=GS A0A3Q0DIN0_TARSY/47-148     AC A0A3Q0DIN0.1
#=GS A0A3P8NDI3_ASTCA/12-144     AC A0A3P8NDI3.1
#=GS A0A3P9AAS3_ESOLU/12-202     AC A0A3P9AAS3.1
#=GS A0A3Q3NJC2_9TELE/12-173     AC A0A3Q3NJC2.1
#=GS R4GBN9_ANOCA/2-108          AC R4GBN9.1
#=GS A0A2I3H7S5_NOMLE/2-48       AC A0A2I3H7S5.1
#=GS L5L5Q0_PTEAL/2-51           AC L5L5Q0.1
#=GS A0A2K6MJT0_RHIBE/1-84       AC A0A2K6MJT0.1
#=GS X1WG03_DANRE/1-94           AC X1WG03.1
#=GS L5JQ74_PTEAL/27-137         AC L5JQ74.1
#=GS A0A3Q7RD69_VULVU/2-151      AC A0A3Q7RD69.1
#=GS W5Q3J1_SHEEP/3-134          AC W5Q3J1.1
#=GS A0A1S3MVS4_SALSA/2-174      AC A0A1S3MVS4.1
#=GS A0A2K5CPZ1_AOTNA/2-116      AC A0A2K5CPZ1.1
#=GS A0A3P8RF49_ASTCA/2-162      AC A0A3P8RF49.1
#=GS M4AGH6_XIPMA/2-157          AC M4AGH6.2
#=GS A0A3B4DIZ6_PYGNA/54-264     AC A0A3B4DIZ6.1
#=GS H2Q648_PANTR/3-166          AC H2Q648.2
#=GS A0A1U7QKR2_MESAU/2-185      AC A0A1U7QKR2.1
#=GS R4GMQ8_HUMAN/3-90           AC R4GMQ8.1
#=GS A0A3Q1EF25_9TELE/2-167      AC A0A3Q1EF25.1
#=GS A0A402FEG1_9SAUR/2-71       AC A0A402FEG1.1
#=GS I3NE93_ICTTR/2-107          AC I3NE93.2
#=GS A0A2Y9JWP7_ENHLU/2-194      AC A0A2Y9JWP7.1
#=GS A0A3Q2W893_HAPBU/12-173     AC A0A3Q2W893.1
#=GS A0A091FE46_CORBR/2-108      AC A0A091FE46.1
#=GS A0A096MVW3_PAPAN/2-116      AC A0A096MVW3.2
#=GS PPR1B_MOUSE/2-183           AC Q60829.2
#=GS J9P5V9_CANLF/69-216         AC J9P5V9.1
#=GS A0A091JLH5_EGRGA/2-101      AC A0A091JLH5.1
#=GS A0A1S3P816_SALSA/2-222      AC A0A1S3P816.1
#=GS A0A2K5C493_AOTNA/47-148     AC A0A2K5C493.1
#=GS A0A2K5WIU3_MACFA/2-109      AC A0A2K5WIU3.1
#=GS A0A2K5QU91_CEBCA/3-91       AC A0A2K5QU91.1
#=GS A0A452R016_URSAM/1-149      AC A0A452R016.1
#=GS A0A3Q3BEH7_KRYMA/12-167     AC A0A3Q3BEH7.1
#=GS A0A2K5VVQ3_MACFA/2-48       AC A0A2K5VVQ3.1
#=GS D2HM60_AILME/3-166          AC D2HM60.1
#=GS A0A2R9AD34_PANPA/12-166     AC A0A2R9AD34.1
#=GS A0A2K6LVS7_RHIBE/2-181      AC A0A2K6LVS7.1
#=GS A0A2I3MZ80_PAPAN/2-48       AC A0A2I3MZ80.1
#=GS A0A2K5WK45_MACFA/3-46       AC A0A2K5WK45.1
#=GS A0A1L1RXZ8_CHICK/2-212      AC A0A1L1RXZ8.2
#=GS A0A2K6A996_MANLE/1-138      AC A0A2K6A996.1
#=GS A0A2K5EYT6_AOTNA/3-152      AC A0A2K5EYT6.1
#=GS A0A3B4APQ5_9GOBI/2-31       AC A0A3B4APQ5.1
#=GS A0A2K5LYP2_CERAT/2-109      AC A0A2K5LYP2.1
#=GS A0A1S3P7Y3_SALSA/2-221      AC A0A1S3P7Y3.1
#=GS H2TFB9_TAKRU/2-192          AC H2TFB9.2
#=GS A0A1L8HIE3_XENLA/47-221     AC A0A1L8HIE3.1
#=GS A0A3Q3SAK0_9TELE/2-203      AC A0A3Q3SAK0.1
#=GS A0A340XPP3_LIPVE/2-117      AC A0A340XPP3.1
#=GS A0A3Q3FLH7_9LABR/2-211      AC A0A3Q3FLH7.1
#=GS A0A3Q2UG29_CHICK/2-59       AC A0A3Q2UG29.1
#=GS A0A3Q3NA57_9TELE/2-151      AC A0A3Q3NA57.1
#=GS A0A060Z8P4_ONCMY/2-61       AC A0A060Z8P4.1
#=GS I3MB48_ICTTR/3-159          AC I3MB48.1
#=GS A0A1S2ZNR1_ERIEU/2-109      AC A0A1S2ZNR1.1
#=GS A0A2U3VK05_ODORO/2-194      AC A0A2U3VK05.1
#=GS A0A2I3MZ80_PAPAN/47-148     AC A0A2I3MZ80.1
#=GS A0A3B5BDB7_9TELE/4-58       AC A0A3B5BDB7.1
#=GS W5MHU3_LEPOC/2-165          AC W5MHU3.1
#=GS A0A3P8WGM7_CYNSE/12-161     AC A0A3P8WGM7.1
#=GS A0A099Z8D4_TINGU/2-121      AC A0A099Z8D4.1
#=GS A0A2D0S7F9_ICTPU/4-160      AC A0A2D0S7F9.1
#=GS A0A2D0S6V4_ICTPU/1-139      AC A0A2D0S6V4.1
#=GS A0A2Y9L170_ENHLU/3-166      AC A0A2Y9L170.1
#=GS A0A2K5HUE1_COLAP/3-166      AC A0A2K5HUE1.1
#=GS A0A2U3XBC5_LEPWE/81-188     AC A0A2U3XBC5.1
#=GS A0A3P8V997_CYNSE/53-127     AC A0A3P8V997.1
#=GS A0A3B4DIN8_PYGNA/2-170      AC A0A3B4DIN8.1
#=GS A0A2K5LR31_CERAT/3-166      AC A0A2K5LR31.1
#=GS G3H5X5_CRIGR/2-48           AC G3H5X5.1
#=GS A0A2K5PV59_CEBCA/48-149     AC A0A2K5PV59.1
#=GS A0A0Q3X8Q9_AMAAE/2-118      AC A0A0Q3X8Q9.1
#=GS A0A3B5QV14_XIPMA/12-178     AC A0A3B5QV14.1
#=GS G1L8T1_AILME/2-116          AC G1L8T1.1
#=GS J3KT77_HUMAN/47-148         AC J3KT77.1
#=GS A0A2J8W9V8_PONAB/2-181      AC A0A2J8W9V8.1
#=GS A0A3B4WNG2_SERLL/12-176     AC A0A3B4WNG2.1
#=GS A0A226N7U3_CALSU/2-71       AC A0A226N7U3.1
#=GS A0A2K6LVP0_RHIBE/47-167     AC A0A2K6LVP0.1
#=GS A0A402FEG1_9SAUR/101-305    AC A0A402FEG1.1
#=GS A0A2U9BG99_SCOMX/2-155      AC A0A2U9BG99.1
#=GS A0A3P8YP72_ESOLU/2-167      AC A0A3P8YP72.1
#=GS A0A1U8BKK6_MESAU/3-167      AC A0A1U8BKK6.1
#=GS A0A3P8S0H9_AMPPE/9-145      AC A0A3P8S0H9.1
#=GS A0A3B3UXS9_9TELE/64-228     AC A0A3B3UXS9.1
#=GS A0A383ZX03_BALAS/3-158      AC A0A383ZX03.1
#=GS A0A3P8T901_AMPPE/17-181     AC A0A3P8T901.1
#=GS A0A3Q4BYB8_MOLML/12-145     AC A0A3Q4BYB8.1
#=GS R4GCQ1_ANOCA/2-174          AC R4GCQ1.1
#=GS A0A2U4B1U5_TURTR/2-116      AC A0A2U4B1U5.1
#=GS A0A3Q2EB35_CYPVA/12-138     AC A0A3Q2EB35.1
#=GS A0A2I3GXL7_NOMLE/2-116      AC A0A2I3GXL7.1
#=GS A0A2Y9SSX3_PHYMC/3-168      AC A0A2Y9SSX3.1
#=GS F7HI10_CALJA/2-182          AC F7HI10.1
#=GS A0A2U3WCL5_ODORO/3-166      AC A0A2U3WCL5.1
#=GS A0A1V4K6U6_PATFA/57-163     AC A0A1V4K6U6.1
#=GS A0A2I4CHE3_9TELE/2-104      AC A0A2I4CHE3.1
#=GS A0A2K6PCI1_RHIRO/2-195      AC A0A2K6PCI1.1
#=GS E1BYA0_CHICK/61-167         AC E1BYA0.2
#=GS A0A0R4I9N8_DANRE/12-149     AC A0A0R4I9N8.1
#=GS A0A2I3H7S5_NOMLE/47-167     AC A0A2I3H7S5.1
#=GS A0A2J8PRM2_PANTR/2-109      AC A0A2J8PRM2.1
#=GS Q7SYH1_XENLA/2-183          AC Q7SYH1.1
#=GS A0A452FMC6_CAPHI/2-106      AC A0A452FMC6.1
#=GS A0A337SE57_FELCA/2-195      AC A0A337SE57.1
#=GS A0A0D9QZA7_CHLSB/3-166      AC A0A0D9QZA7.1
#=GS A0A1U7US16_TARSY/59-108     AC A0A1U7US16.2
#=GS A0A2I2U0J1_FELCA/2-95       AC A0A2I2U0J1.1
#=GS A0A3B4ZWN1_9TELE/31-141     AC A0A3B4ZWN1.1
#=GS G1SYN7_RABIT/2-109          AC G1SYN7.2
#=GS F1N3V8_BOVIN/3-157          AC F1N3V8.2
#=GS A0A3B3QFU4_9TELE/85-252     AC A0A3B3QFU4.1
#=GS PPR1C_HUMAN/2-109           AC Q8WVI7.1
#=GS A0A1U8D3Q5_ALLSI/2-196      AC A0A1U8D3Q5.1
#=GS A0A3B3TE17_9TELE/2-31       AC A0A3B3TE17.1
#=GS PPR1B_PIG/1-137             AC Q29277.1
#=GS A0A0P7UPU0_SCLFO/1-104      AC A0A0P7UPU0.1
#=GS A0A091DRW9_FUKDA/45-146     AC A0A091DRW9.1
#=GS A0A2U3WCL6_ODORO/3-76       AC A0A2U3WCL6.1
#=GS A0A2K6BAS2_MACNE/2-109      AC A0A2K6BAS2.1
#=GS A0A226NQX0_COLVI/65-263     AC A0A226NQX0.1
#=GS A0A3P9NMN0_POERE/2-197      AC A0A3P9NMN0.1
#=GS A0A3Q7SNB6_VULVU/2-162      AC A0A3Q7SNB6.1
#=GS A0A3Q3EZS1_9LABR/18-170     AC A0A3Q3EZS1.1
#=GS A0A2K5C489_AOTNA/2-194      AC A0A2K5C489.1
#=GS J9P7V4_CANLF/1-84           AC J9P7V4.1
#=GS A0A2R9A0A7_PANPA/1-144      AC A0A2R9A0A7.1
#=GS A0A2K6RRE6_RHIRO/2-109      AC A0A2K6RRE6.1
#=GS A0A3Q1FFV9_9TELE/17-181     AC A0A3Q1FFV9.1
#=GS A0A2K6QP89_RHIRO/3-166      AC A0A2K6QP89.1
#=GS A0A3Q7VGH1_URSAR/2-109      AC A0A3Q7VGH1.1
#=GS A0A087XWH5_POEFO/12-182     AC A0A087XWH5.2
#=GS A0A1U7RMX7_ALLSI/2-108      AC A0A1U7RMX7.1
#=GS A0A2K5P461_CERAT/47-167     AC A0A2K5P461.1
#=GS A0A2K5XNR1_MANLE/2-116      AC A0A2K5XNR1.1
#=GS A0A3B3H9Y0_ORYLA/32-207     AC A0A3B3H9Y0.1
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A0A2U3XBS0_LEPWE/3-72                  ...................................qd--NSPR.KIQFTVPLL.EPHLDPEAAE.............Q.......IRR............RRPTPATLVLT..S......DQS.SPE.........iDED.R......I...........P......N...........P.......L.LK..HGK----...-----.------...---............-...-.-.-..--.....-.-..--..--.-..-.-.--............-------..................................................................................--.-.----.-.--..-.---.............--------.-..-.-.-.-...-.-.-..-----.-------------................................---------aqkagekg...............................................................................................................
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H1A2T0_TAEGU/2-47                      .....................................EPNSPK.KIQFAVPLF.QSQIDPEAAE.............Q.......IRK............RRPTPASLVIM..N......EHM.P--..........---.-......-...........-......-...........-.......-.--..-------...-----.------...---............-...-.-.-..--.....-.-..--..--.-..-.-.--............-------..................................................................................--.-.----.-.--..-.---.............--------.-..-.-.-.-...-.-.-..-----.-------------................................---------p......................................................................................................................
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L5JQ74_PTEAL/2-31                      .....................................DPKDRK.KIQFSVPAP.PSQLDPRQVE.............M.......QR-............-----------..-......---.---..........---.-......-...........-......-...........-.......-.--..-------...-----.------...---............-...-.-.-..--.....-.-..--..--.-..-.-.--............-------..................................................................................--.-.----.-.--..-.---.............--------.-..-.-.-.-...-.-.-..-----.-------------................................---------as.....................................................................................................................
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A0A455AVJ2_PHYMC/2-197                 .....................................DPKDRK.KIQFSVPAP.PSQLDPRQVE.............M.......IRR............RRPTPAMLFRL..S......EHS.SPE..........EEA.S......P...........H......Q..........qR.......A.SG..EGHHLKS...KRANP.CAYTPP...SLK............A...V.Q.R..IA.....E.S..HL..QS.I..S.-.--............NLGENQ-..................................................................................AS.E.EEDE.L.GE..L.R--.............ELGYPREE.E..E.E.E.E...EdD.E..EEEEE.EEDSQAEILKGSRgsagqkttcgqgl......egpsegpppldepQRDGSSED-qgedpalnepgeepq........................................................................................................
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A0A2I0MIW2_COLLI/57-115                .....................................EPNSPK.KIQFAVPLF.QSQIDPEAAE.............Q.......IRK............RRPTPASLVIM..N......EHV.PPD..........TWY.S......T...........K......-...........-.......-.--..-------...-----.------...---............-...-.-.-..--.....-.-..--..--.-..-.-.--............-------..................................................................................--.-.----.-.--..-.---.............--------.-..-.-.-.-...-.-.-..-----.-------------................................---------skpnre.................................................................................................................
A0A2U3ZGN9_ODORO/2-116                 .....................................EPNSPK.KIQFAVPLF.QSQIAPEAAE.............QlglccsqIRK............RRPTPASLVIL..N......EHN.PPE..........TDD.K......R...........V......T...........N.......T.QA..ESQNASP...KQRKQ.SVYTPP...AMK............G...V.K.H..LK.....G.Q..NE..SA.F..P.E.EE...........eGVNEREE..................................................................................--.-.----.-.--..-.---.............--------.-..-.-.-.-...-.-.-..-----.-------------................................---------qweh...................................................................................................................
A0A2U3X6A9_LEPWE/2-116                 .....................................EPNSPK.KIQFAVPLF.QSQIAPEAAE.............QlglccsqIRK............RRPTPASLVIL..N......EHN.PPE.........iDDK.R......V...........T......-...........N.......T.QA..ESQNASP...KQRKQ.SVYTPP...AMK............G...V.K.H..LK.....G.Q..NE..SA.F..P.E.EE...........eGVNEREE..................................................................................--.-.----.-.--..-.---.............--------.-..-.-.-.-...-.-.-..-----.-------------................................---------qweh...................................................................................................................
A0A2I4CLM9_9TELE/2-170                 .....................................EPGSPK.KIQFAVPPL.QGQLDPQAAE.............H.......IRR............RRPTPATLQIY..R......PSS.D--..........--V.G......D...........H......Q...........N.......T.SG..DPQVLQTsdaSQRKQ.STYAPP...TMK............E...L.Q.L..GV.....E.Q..HL..LE.A..G.L.CEt.........dsQLS---Pitaqlcataypwanhn..................................................epeeangneacsplanH-.-.---Q.R.EV..E.QSNssg.......gklETSVPEEE.E..E.E.E.E...Q.-.-..-----.-------------................................---------tnsqdd.................................................................................................................
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E1BPZ4_BOVIN/2-109                     .....................................EPNSPK.KIQFAVPLF.QSQIAPEAAE.............Q.......IRK............RRPTPASLVIL..N......EHN.PPE.........iDDK.R......V...........T......-...........N.......T.QA..EAQNATP...KQRKQ.SVYTAP...AMK............G...V.K.H..MK.....G.Q..NE..SA.F..P.E.EE...........eGVNE---..................................................................................--.-.----.-.--..-.---.............--------.-..-.-.-.-...-.-.-..-----.-------------................................---------raqqwdh................................................................................................................
PPR1C_PONAB/2-109                      .....................................EPNSPK.KIQFAVPVF.QSQIAPEAAE.............Q.......IRK............RRPTPASLVIL..N......EHN.PPE.........iDDK.R......V...........P......N...........-.......T.QG..ELQNASP...KQRKQ.SVYTPP...TIK............G...V.K.H..LK.....G.Q..NE..SA.F..-.-.--............--PEEEE..................................................................................--.-.----.-.--..-.---.............--------.-..-.-.-.-...-.-.-..-----.-------------................................---------gtnereeqrdh............................................................................................................
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A0A3Q1G291_9TELE/2-211                 ....................................e-TGSPR.KIQFTVPLL.DTHLDPEAAE.............Q.......IRR............RRPTPATLVAS..S......DQS.SPE.........iDED.R......L...........P......N...........Q.......L.YK..AALLNSP...RQRRK.GQKGTP...TMK............E...L.Q.F..MV.....E.H..HL..YR.Q..Q.Q.GAgdec....ssesCLSDRPSpdsvptgeelphddettaeafek...................................lrcqmeefsreslleaagglecplSK.E.KEDC.S.SV..A.NVA.............DPSSQQN-.-..-.-.-.-...-.-.-..-----.-------------................................---------saqadtkagassasqpaeektkkcslekek.........................................................................................
A0A1S3PNM8_SALSA/10-178                .....................................EPNSPK.KIQFSVPVF.QSQLDPQASE.............H.......IRK............RRPTPATHAIYlpP......DLT.AAD..........DKQ.T......T...........S......H...........Q.......G.ET..QSAGTSP...AQRKH.SVYTPP...TMK............D...C.C.-..--.....-.-..--..--.-..-.-.--............-------..................................................................................--.-.----.-.--..-.---.............--------.-..-.-.-.-...-.-.-..-----.-------------................................---------rghgedrdslpptrlakshtdtlalaeelsgalprladtprrkdtpyqhqppftpgvkllkskskisfpeeeekeaeeeedtkkk..................................
A0A3B3HD03_ORYLA/2-210                 ....................................e-TGSPR.KIQFTVPLL.DTHLDPEAAE.............Q.......IRR............RRPTPATLVAS..S......DQS.SPE.........iDED.R......L...........P......N...........Q.......L.YK..AALLNSP...RQRRK.GQKGTP...TMK............E...L.Q.F..LV.....E.H..HL..YR.Q..Q.Q.GAgdec....ssesCLSDRPSpdsvptgeelpdddeata.............................................eafeklrcqmeefsresllD-.-.----.-.--..-.---.............--------.-..-.-.-.-...-.-.-..-----.-------------................................---------eaaglkcplprenqecsdvanvpdrspnqkstqkdtkagaasasqssetsktyslekdk............................................................
#=GC seq_cons                          ......................................sps.+.KIQFuVPh...spLDPctsE.....................IRR............RRPTPAoLhhh..s......-ps.SPE..........--p.p.........................p...................h..t..psh.hps...+php..sshpsP...ohK............t...l.Q.h..hs.....p.p..ph..tp....t...................ptt...............................................................................................................................................................................................................pptptt.................................................................................................................
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