GenomeNet

Database: Pfam
Entry: DHHC
LinkDB: DHHC
Original site: DHHC 
#=GF ID   DHHC
#=GF AC   PF01529.21
#=GF DE   DHHC palmitoyltransferase
#=GF PI   zf-DHHC;
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_945 (release 4.0)
#=GF GA   28.70 28.70;
#=GF TC   28.70 28.70;
#=GF NC   28.50 28.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   DHHC_domain
#=GF RN   [1]
#=GF RM   15603741
#=GF RT   Identification of PSD-95 palmitoylating enzymes.
#=GF RA   Fukata M, Fukata Y, Adesnik H, Nicoll RA, Bredt DS;
#=GF RL   Neuron. 2004;44:987-996.
#=GF RN   [2]
#=GF RM   23034182
#=GF RT   Analysis of substrate specificity of human DHHC protein
#=GF RT   acyltransferases using a  yeast expression system.
#=GF RA   Ohno Y, Kashio A, Ogata R, Ishitomi A, Yamazaki Y, Kihara A;
#=GF RL   Mol Biol Cell. 2012;23:4543-4551.
#=GF RN   [3]
#=GF RM   26224664
#=GF RT   The canonical DHHC motif is not absolutely required for the
#=GF RT   activity of the yeast S-acyltransferases Swf1 and Pfa4.
#=GF RA   Gonzalez Montoro A, Chumpen Ramirez S, Valdez Taubas J;
#=GF RL   J Biol Chem. 2015;290:22448-22459.
#=GF RN   [4]
#=GF RM   10231582
#=GF RT   The drosophila STAM gene homolog is in a tight gene cluster, and
#=GF RT   its expression correlates to that of the adjacent gene ial. 
#=GF RA   Mesilaty-Gross S, Reich A, Motro B, Wides R; 
#=GF RL   Gene 1999;231:173-186.
#=GF RN   [5]
#=GF RM   12021275
#=GF RT   Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and
#=GF RT   has pro-apoptotic  activity.
#=GF RA   Li B, Cong F, Tan CP, Wang SX, Goff SP;
#=GF RL   J Biol Chem. 2002;277:28870-28876.
#=GF RN   [6]
#=GF RM   16000296
#=GF RT   DHHC9 and GCP16 constitute a human protein fatty acyltransferase
#=GF RT   with specificity for H- and N-Ras.
#=GF RA   Swarthout JT, Lobo S, Farh L, Croke MR, Greentree WK, Deschenes
#=GF RA   RJ, Linder ME;
#=GF RL   J Biol Chem. 2005;280:31141-31148.
#=GF RN   [7]
#=GF RM   12370247
#=GF RT   The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl
#=GF RT   transferase.
#=GF RA   Roth AF, Feng Y, Chen L, Davis NG;
#=GF RL   J Cell Biol. 2002;159:23-28.
#=GF RN   [8]
#=GF RM   10490616
#=GF RT   Erf2, a Novel Gene Product That Affects the Localization and
#=GF RT   Palmitoylation of Ras2 in Saccharomyces cerevisiae. 
#=GF RA   Bartels DJ, Mitchell DA, Dong X, Deschenes RJ; 
#=GF RL   Mol Cell Biol 1999;19:6775-6787.
#=GF RN   [9]
#=GF RM   16100337
#=GF RT   The TIP GROWTH DEFECTIVE1 S-acyl transferase regulates plant
#=GF RT   cell growth in Arabidopsis.
#=GF RA   Hemsley PA, Kemp AC, Grierson CS;
#=GF RL   Plant Cell. 2005;17:2554-2563.
#=GF DR   INTERPRO; IPR001594;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry refers to the DHHC domain, found in DHHC proteins
#=GF CC   which  are palmitoyltransferases [1]. Palmitoylation or, more
#=GF CC   specifically  S-acylation, plays important roles in the
#=GF CC   regulation of protein  localization, stability, and activity. It
#=GF CC   is a post-translational  protein modification that involves the
#=GF CC   attachment of palmitic acid  to Cys residues through a thioester
#=GF CC   linkage. Protein  acyltransferases (PATs), also known as
#=GF CC   palmitoyltransferases,  catalyze this reaction by transferring
#=GF CC   the palmitoyl group from  palmitoyl-CoA to the thiol group of
#=GF CC   Cys residues. They are  characterized by the presence of a
#=GF CC   50-residue-long domain called  the DHHC domain, which in most
#=GF CC   but not all cases is also  cysteine-rich and gets its name from
#=GF CC   a highly conserved DHHC  signature tetrapeptide
#=GF CC   (Asp-His-His-Cys). The Cys residue within  the DHHC domain forms
#=GF CC   a stable acyl intermediate and transfers the  acyl chain to the
#=GF CC   Cys residues of a target protein [2][3]. Some  proteins
#=GF CC   containing a DHHC domain include Drosophila DNZ1 protein  [4],
#=GF CC   Mouse Abl-philin 2 (Aph2) protein [5], Mammalian ZDHHC9 [6], 
#=GF CC   Yeast ankyrin repeat-containing protein AKR1 [7], Yeast Erf2 
#=GF CC   protein [8], and Arabidopsis thaliana tip growth defective 1
#=GF CC   [9].
#=GF SQ   17127
#=GS F9X752_ZYMTI/1-89           AC F9X752.1
#=GS A0A061GXB1_THECC/150-252    AC A0A061GXB1.1
#=GS A0A2K5IUY1_COLAP/153-305    AC A0A2K5IUY1.1
#=GS A0A0C2X147_9AGAM/93-222     AC A0A0C2X147.1
#=GS R0J0X2_SETT2/126-255        AC R0J0X2.1
#=GS A0A453IDX2_AEGTS/201-330    AC A0A453IDX2.1
#=GS G8YAA2_PICSO/74-206         AC G8YAA2.1
#=GS B4H6D3_DROPE/112-242        AC B4H6D3.1
#=GS A0A1D6EM62_MAIZE/174-314    AC A0A1D6EM62.1
#=GS A0A3B3SWV8_9TELE/126-255    AC A0A3B3SWV8.1
#=GS A0A0E0FB17_9ORYZ/350-457    AC A0A0E0FB17.1
#=GS A0A2H5MX14_CITUN/148-289    AC A0A2H5MX14.1
#=GS A0A182TFU9_9DIPT/114-242    AC A0A182TFU9.1
#=GS M4BKD4_HYAAE/1-139          AC M4BKD4.1
#=GS G1MHW6_AILME/423-559        AC G1MHW6.1
#=GS A0A2Y9P747_DELLE/129-285    AC A0A2Y9P747.1
#=GS A0A0K0DP72_ANGCA/94-239     AC A0A0K0DP72.1
#=GS G0QYL7_ICHMG/149-275        AC G0QYL7.1
#=GS F0ULX9_AJEC8/161-285        AC F0ULX9.1
#=GS A0A3L6QM92_PANMI/107-237    AC A0A3L6QM92.1
#=GS A0A2A2KDT7_9BILA/47-183     AC A0A2A2KDT7.1
#=GS A0A179UPY5_BLAGS/151-304    AC A0A179UPY5.1
#=GS A0A087R672_APTFO/162-295    AC A0A087R672.1
#=GS A0A1R3JUS3_9ROSI/120-263    AC A0A1R3JUS3.1
#=GS A0A177C660_9PLEO/114-238    AC A0A177C660.1
#=GS A0A2U4CPM6_TURTR/160-289    AC A0A2U4CPM6.1
#=GS A0A0K0EWV8_STRVS/115-267    AC A0A0K0EWV8.1
#=GS L8GCE9_PSED2/122-251        AC L8GCE9.1
#=GS A0A0C3F6N8_9AGAM/125-257    AC A0A0C3F6N8.1
#=GS A0A3B4GIG9_9CICH/119-287    AC A0A3B4GIG9.1
#=GS A0A0J8QQT9_COCIT/150-275    AC A0A0J8QQT9.1
#=GS A0A383Z6E2_BALAS/136-265    AC A0A383Z6E2.1
#=GS ZDH20_BOVIN/121-247         AC Q0VC89.1
#=GS B7PS34_IXOSC/124-249        AC B7PS34.1
#=GS K1Y8J5_MARBU/421-551        AC K1Y8J5.1
#=GS A0A0S3SN92_PHAAN/137-267    AC A0A0S3SN92.1
#=GS A0A3P9CA55_9CICH/148-272    AC A0A3P9CA55.1
#=GS A0A158NH53_ATTCE/134-302    AC A0A158NH53.1
#=GS B1N5J3_ENTHI/141-273        AC B1N5J3.1
#=GS M2U4B8_COCH5/153-316        AC M2U4B8.1
#=GS A0A091VNB8_NIPNI/150-289    AC A0A091VNB8.1
#=GS A0A137PGK5_CONC2/54-188     AC A0A137PGK5.1
#=GS A0A3Q3FVE0_9LABR/99-224     AC A0A3Q3FVE0.1
#=GS A0A103YKR9_CYNCS/377-510    AC A0A103YKR9.1
#=GS A0A3Q4M5N5_NEOBR/99-224     AC A0A3Q4M5N5.1
#=GS G0QPP3_ICHMG/85-222         AC G0QPP3.1
#=GS A0A1U7SUD8_TARSY/85-218     AC A0A1U7SUD8.1
#=GS A0A074W618_9PEZI/177-301    AC A0A074W618.1
#=GS A0A367L6C3_9HYPO/151-299    AC A0A367L6C3.1
#=GS A0A1J9P7F3_9EURO/151-304    AC A0A1J9P7F3.1
#=GS A0A2K5HQ36_COLAP/99-224     AC A0A2K5HQ36.1
#=GS F7D678_MONDO/164-293        AC F7D678.2
#=GS M2NFX2_BAUPA/158-287        AC M2NFX2.1
#=GS A0A397Z3N8_BRACM/144-275    AC A0A397Z3N8.1
#=GS A0A267EQB0_9PLAT/197-323    AC A0A267EQB0.1
#=GS A0A427YNJ7_9TREE/143-271    AC A0A427YNJ7.1
#=GS A0A316YQP0_9BASI/1068-1211  AC A0A316YQP0.1
#=GS A0A319C4A2_9EURO/402-531    AC A0A319C4A2.1
#=GS U4LSR3_PYROM/94-228         AC U4LSR3.1
#=GS A0A384BAT8_BALAS/99-224     AC A0A384BAT8.1
#=GS A0A3Q7FQ35_SOLLC/149-280    AC A0A3Q7FQ35.1
#=GS A0A3B3D9P5_ORYME/124-253    AC A0A3B3D9P5.1
#=GS A0A1D2MRG9_ORCCI/157-285    AC A0A1D2MRG9.1
#=GS G3ARQ4_SPAPN/53-181         AC G3ARQ4.1
#=GS A0A2Y9M3J1_DELLE/417-553    AC A0A2Y9M3J1.1
#=GS A0A2P6P7Y1_ROSCH/126-255    AC A0A2P6P7Y1.1
#=GS E7F021_DANRE/97-223         AC E7F021.1
#=GS A0A1E3P5T6_WICAA/133-264    AC A0A1E3P5T6.1
#=GS A0A210PHG9_MIZYE/117-243    AC A0A210PHG9.1
#=GS A0A2A3EKM2_APICC/408-547    AC A0A2A3EKM2.1
#=GS A0A445J6R8_GLYSO/120-249    AC A0A445J6R8.1
#=GS A0A452G0R6_CAPHI/468-579    AC A0A452G0R6.1
#=GS A0A3B3YTK0_9TELE/243-377    AC A0A3B3YTK0.1
#=GS A0A2H3XYC2_PHODC/365-498    AC A0A2H3XYC2.1
#=GS A0A067E7P0_CITSI/91-124     AC A0A067E7P0.1
#=GS A0A3B3WIL9_9TELE/99-224     AC A0A3B3WIL9.1
#=GS A0A1B7MVD6_9AGAM/376-510    AC A0A1B7MVD6.1
#=GS A0A3B0J350_DROGU/124-254    AC A0A3B0J350.1
#=GS A0A3Q3SUY2_9TELE/99-224     AC A0A3Q3SUY2.1
#=GS G0S146_CHATD/364-494        AC G0S146.1
#=GS A0A1U7S0U2_ALLSI/162-291    AC A0A1U7S0U2.1
#=GS A0A2I0B140_9ASPA/72-201     AC A0A2I0B140.1
#=GS A0A2R6QBY7_ACTCH/154-311    AC A0A2R6QBY7.1
#=GS R7T6R7_CAPTE/142-270        AC R7T6R7.1
#=GS C0NMD1_AJECG/393-531        AC C0NMD1.1
#=GS A0A482WLS1_LAOST/113-255    AC A0A482WLS1.1
#=GS H3CLW6_TETNG/137-267        AC H3CLW6.1
#=GS A0A0K9QCJ4_SPIOL/74-225     AC A0A0K9QCJ4.1
#=GS A0A1V6S2G5_9EURO/150-296    AC A0A1V6S2G5.1
#=GS A0A3B4BS66_PYGNA/104-230    AC A0A3B4BS66.1
#=GS A0A445E2I4_ARAHY/102-242    AC A0A445E2I4.1
#=GS A0A0K9NN50_ZOSMR/373-506    AC A0A0K9NN50.1
#=GS A0A1R3HYK3_COCAP/358-490    AC A0A1R3HYK3.1
#=GS A0A2J8XXU0_PONAB/151-305    AC A0A2J8XXU0.1
#=GS A0A3B0J517_DROGU/425-561    AC A0A3B0J517.1
#=GS A0A067JY22_JATCU/120-249    AC A0A067JY22.1
#=GS A0A3Q1BHE7_AMPOC/339-472    AC A0A3Q1BHE7.1
#=GS A0A2K5S9I6_CEBCA/159-288    AC A0A2K5S9I6.1
#=GS A0A3S5WGI8_9MAGN/138-267    AC A0A3S5WGI8.1
#=GS A0A2K6UGU6_SAIBB/99-224     AC A0A2K6UGU6.1
#=GS I1JCY3_SOYBN/145-276        AC I1JCY3.1
#=GS A0A137P958_CONC2/220-355    AC A0A137P958.1
#=GS L9JBL0_TUPCH/110-298        AC L9JBL0.1
#=GS J3LIF2_ORYBR/90-216         AC J3LIF2.1
#=GS Q22BC3_TETTS/349-485        AC Q22BC3.3
#=GS A0A0D8XWI6_DICVI/117-218    AC A0A0D8XWI6.1
#=GS A0A2P6SJB5_ROSCH/91-218     AC A0A2P6SJB5.1
#=GS A0A086SVQ4_ACRC1/118-268    AC A0A086SVQ4.1
#=GS A0A1J7J075_9PEZI/540-677    AC A0A1J7J075.1
#=GS A0A3Q7GZH2_SOLLC/149-280    AC A0A3Q7GZH2.1
#=GS A0A482XR05_LAOST/160-297    AC A0A482XR05.1
#=GS A0A286ZMX4_PIG/99-224       AC A0A286ZMX4.1
#=GS A0A1A0HCI7_9ASCO/166-302    AC A0A1A0HCI7.1
#=GS A0A0K0DYK5_STRER/124-265    AC A0A0K0DYK5.1
#=GS A0A1S3RHA3_SALSA/226-265    AC A0A1S3RHA3.1
#=GS A0A072UR39_MEDTR/199-331    AC A0A072UR39.1
#=GS A0A402FR05_9SAUR/119-244    AC A0A402FR05.1
#=GS A0A3N7GQN0_POPTR/145-186    AC A0A3N7GQN0.1
#=GS A0A3P9BPA2_9CICH/424-560    AC A0A3P9BPA2.1
#=GS A0A3B3DFJ5_ORYME/119-244    AC A0A3B3DFJ5.1
#=GS W9QV74_9ROSA/160-291        AC W9QV74.1
#=GS A0A017SHY5_9EURO/125-254    AC A0A017SHY5.1
#=GS A0A161V3P3_9PEZI/115-244    AC A0A161V3P3.1
#=GS A0A2I4AUI6_9TELE/99-224     AC A0A2I4AUI6.1
#=GS A0A1W4XIZ8_AGRPL/84-226     AC A0A1W4XIZ8.1
#=GS A0A1S4DRH6_TOBAC/373-506    AC A0A1S4DRH6.1
#=GS A0A061DC06_BABBI/105-243    AC A0A061DC06.1
#=GS A0A3B4DFB6_PYGNA/147-308    AC A0A3B4DFB6.1
#=GS A0A395NP04_TRIAR/80-213     AC A0A395NP04.1
#=GS A0A3Q3B665_KRYMA/98-242     AC A0A3Q3B665.1
#=GS A0DRQ8_PARTE/325-456        AC A0DRQ8.1
#=GS A0A2K5SDC8_CEBCA/187-316    AC A0A2K5SDC8.1
#=GS M4CJJ6_BRARP/156-296        AC M4CJJ6.1
#=GS A0A182Y9U2_ANOST/1802-1944  AC A0A182Y9U2.1
#=GS F2EJY1_HORVV/146-276        AC F2EJY1.1
#=GS A0A0K3C963_RHOTO/901-1091   AC A0A0K3C963.1
#=GS A0A1D6HFL4_MAIZE/146-197    AC A0A1D6HFL4.1
#=GS A0A445F649_GLYSO/137-267    AC A0A445F649.1
#=GS A0A3Q1FVL0_9TELE/239-373    AC A0A3Q1FVL0.1
#=GS A0A421JP51_9ASCO/1-102      AC A0A421JP51.1
#=GS K5WHI4_PHACS/122-256        AC K5WHI4.1
#=GS M4ALB1_XIPMA/95-233         AC M4ALB1.1
#=GS A0A3Q4HZW2_NEOBR/123-250    AC A0A3Q4HZW2.1
#=GS A0A453NGX4_AEGTS/157-290    AC A0A453NGX4.1
#=GS A0A1J9QBK8_9EURO/151-304    AC A0A1J9QBK8.1
#=GS A0A026WEE2_OOCBI/84-216     AC A0A026WEE2.1
#=GS T1F1D2_HELRO/284-422        AC T1F1D2.1
#=GS B4MW18_DROWI/253-394        AC B4MW18.1
#=GS A0A067CAY6_SAPPC/369-484    AC A0A067CAY6.1
#=GS A0A163JYD0_ABSGL/124-253    AC A0A163JYD0.1
#=GS B3L513_PLAKH/101-241        AC B3L513.1
#=GS A0A3B1JTP1_ASTMX/118-244    AC A0A3B1JTP1.1
#=GS A0A3B3QD15_9TELE/118-273    AC A0A3B3QD15.1
#=GS A0A3N7GEG1_POPTR/156-263    AC A0A3N7GEG1.1
#=GS A0A195CAX6_9HYME/123-280    AC A0A195CAX6.1
#=GS A0A284QVY8_9AGAR/260-392    AC A0A284QVY8.1
#=GS V4SGT3_9ROSI/152-273        AC V4SGT3.1
#=GS ZDH24_ARATH/132-255         AC Q8VYS8.1
#=GS A0A1J7I158_LUPAN/177-306    AC A0A1J7I158.1
#=GS U3IZK6_ANAPP/149-303        AC U3IZK6.2
#=GS A0A384BKA1_URSMA/424-469    AC A0A384BKA1.1
#=GS A0A1L9X1C3_ASPAC/111-244    AC A0A1L9X1C3.1
#=GS A0A3Q0RYA2_AMPCI/153-284    AC A0A3Q0RYA2.1
#=GS A0A1B8D5H9_9PEZI/447-585    AC A0A1B8D5H9.1
#=GS A0A3B6SJM0_WHEAT/159-288    AC A0A3B6SJM0.1
#=GS A0A2K6AK57_MANLE/80-223     AC A0A2K6AK57.1
#=GS A0A452EB36_CAPHI/122-239    AC A0A452EB36.1
#=GS E9HMQ2_DAPPU/94-225         AC E9HMQ2.1
#=GS A0A0N4TPW0_BRUPA/131-270    AC A0A0N4TPW0.1
#=GS A0A3Q1CR13_AMPOC/94-220     AC A0A3Q1CR13.1
#=GS A0A1B8GTX1_9PEZI/451-581    AC A0A1B8GTX1.1
#=GS A0A2T3AVR3_AMORE/92-225     AC A0A2T3AVR3.1
#=GS A0A2K5VSF9_MACFA/99-224     AC A0A2K5VSF9.1
#=GS A0A0L8GAU9_OCTBM/127-255    AC A0A0L8GAU9.1
#=GS A0A384D0J4_URSMA/151-305    AC A0A384D0J4.1
#=GS A0A167AX37_9PEZI/140-263    AC A0A167AX37.1
#=GS A0A1V4KFV9_PATFA/101-234    AC A0A1V4KFV9.1
#=GS A0A1J8QXK8_9AGAM/1054-1187  AC A0A1J8QXK8.1
#=GS A0A3B0JBY0_DROGU/258-400    AC A0A3B0JBY0.1
#=GS A0A3B3UPT7_9TELE/97-223     AC A0A3B3UPT7.1
#=GS A0A3B5QHI3_XIPMA/103-232    AC A0A3B5QHI3.1
#=GS A0A091F5B2_CORBR/79-204     AC A0A091F5B2.1
#=GS H2L3R9_ORYLA/118-273        AC H2L3R9.2
#=GS A0A0E0ML54_ORYPU/181-350    AC A0A0E0ML54.1
#=GS A0A1D5Q5Z1_MACMU/91-199     AC A0A1D5Q5Z1.1
#=GS A0A1J7HUK8_LUPAN/89-143     AC A0A1J7HUK8.1
#=GS A0A135UHF6_9PEZI/443-597    AC A0A135UHF6.1
#=GS A0A1Q3AQH8_CEPFO/150-266    AC A0A1Q3AQH8.1
#=GS A0A3Q1IG93_ANATE/125-254    AC A0A3Q1IG93.1
#=GS M4AH22_XIPMA/119-244        AC M4AH22.2
#=GS A0A3Q1BEZ9_AMPOC/139-268    AC A0A3Q1BEZ9.1
#=GS A0A2K5MB60_CERAT/125-249    AC A0A2K5MB60.1
#=GS G3U2Z9_LOXAF/106-232        AC G3U2Z9.1
#=GS A0A3Q7WU35_URSAR/134-263    AC A0A3Q7WU35.1
#=GS A0A0A1NLL7_RHIZD/137-284    AC A0A0A1NLL7.1
#=GS B8BPM7_ORYSI/147-271        AC B8BPM7.1
#=GS A0A0A2KXY0_PENIT/151-296    AC A0A0A2KXY0.1
#=GS A0A2K6L9D4_RHIBE/253-387    AC A0A2K6L9D4.1
#=GS A0A1Z5SYB1_HORWE/440-579    AC A0A1Z5SYB1.1
#=GS A0A4D9ADW7_SALSN/143-174    AC A0A4D9ADW7.1
#=GS A0A3Q2W8T1_HAPBU/138-267    AC A0A3Q2W8T1.1
#=GS A0A0D3A818_BRAOL/172-313    AC A0A0D3A818.1
#=GS A0A067RHK7_ZOONE/126-251    AC A0A067RHK7.1
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#=GS A0A0D3HHU7_9ORYZ/211-299    AC A0A0D3HHU7.1
#=GS A0A0D2NU86_GOSRA/160-284    AC A0A0D2NU86.1
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#=GS I1JMX8_SOYBN/154-279        AC I1JMX8.2
#=GS A0A1W4UZK9_DROFC/124-254    AC A0A1W4UZK9.1
#=GS A0A3Q1GHN0_9TELE/119-274    AC A0A3Q1GHN0.1
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#=GS L1I637_GUITC/1-135          AC L1I637.1
#=GS V4RTR1_9ROSI/152-190        AC V4RTR1.1
#=GS A0A0L0SQD2_ALLM3/87-221     AC A0A0L0SQD2.1
#=GS J3NYA7_GAGT3/118-247        AC J3NYA7.1
#=GS A0A2K5XBT2_MANLE/120-245    AC A0A2K5XBT2.1
#=GS A0A368SUC5_SETIT/164-303    AC A0A368SUC5.1
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#=GS A0A1I8PBT4_STOCA/133-315    AC A0A1I8PBT4.1
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#=GS A0A3Q4ML39_NEOBR/334-466    AC A0A3Q4ML39.1
#=GS T1MUI3_TRIUA/307-346        AC T1MUI3.1
#=GS A0A0W8AXW3_PHYNI/400-563    AC A0A0W8AXW3.1
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#=GS A0A1S3TCI7_VIGRR/111-240    AC A0A1S3TCI7.1
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#=GS A0A2P6MRK1_9MYCE/524-629    AC A0A2P6MRK1.1
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#=GS A0A2P5FEM3_TREOI/134-264    AC A0A2P5FEM3.1
#=GS A0A0M8N177_9HYPO/114-262    AC A0A0M8N177.1
#=GS A0A444X034_ARAHY/162-302    AC A0A444X034.1
#=GS H3DJC8_TETNG/157-291        AC H3DJC8.1
#=GS A0A401SGV0_CHIPU/124-253    AC A0A401SGV0.1
#=GS A0A421JQ15_9ASCO/601-746    AC A0A421JQ15.1
#=GS A0A1W4VCT1_DROFC/124-260    AC A0A1W4VCT1.1
#=GS A0A0C3E124_9PEZI/158-281    AC A0A0C3E124.1
#=GS A0A2K0USJ6_GIBNY/319-449    AC A0A2K0USJ6.1
#=GS M0SGW1_MUSAM/133-262        AC M0SGW1.1
#=GS A0A0N4V2P7_ENTVE/124-251    AC A0A0N4V2P7.1
#=GS A0A2H5TAK5_RHIID/113-241    AC A0A2H5TAK5.1
#=GS G1NWP6_MYOLU/94-244         AC G1NWP6.1
#=GS A0A455C6V3_PHYMC/2-151      AC A0A455C6V3.1
#=GS T1I5S7_RHOPR/390-507        AC T1I5S7.1
#=GS A0A093HV54_STRCA/85-218     AC A0A093HV54.1
#=GS A0A146FWA9_9EURO/125-256    AC A0A146FWA9.1
#=GS A0A2K5W0Z9_MACFA/157-286    AC A0A2K5W0Z9.1
#=GS A0A2Y9D916_TRIMA/422-558    AC A0A2Y9D916.1
#=GS A0A1B9IYQ9_9TREE/433-563    AC A0A1B9IYQ9.1
#=GS K5X7Z7_AGABU/88-218         AC K5X7Z7.1
#=GS A0A165ZCC6_9AGAM/265-407    AC A0A165ZCC6.1
#=GS A0A074YDN7_AURSE/151-298    AC A0A074YDN7.1
#=GS A0A024UU90_9STRA/130-269    AC A0A024UU90.1
#=GS W7X506_TETTS/183-310        AC W7X506.1
#=GS A0A0K6G920_9AGAM/165-293    AC A0A0K6G920.1
#=GS A0A401PCU2_SCYTO/388-520    AC A0A401PCU2.1
#=GS A0A2K5CFP0_AOTNA/406-542    AC A0A2K5CFP0.1
#=GS A0A1V9Z735_9STRA/94-157     AC A0A1V9Z735.1
#=GS G5BWY5_HETGA/84-227         AC G5BWY5.1
#=GS A0A0V0WD64_9BILA/2484-2664  AC A0A0V0WD64.1
#=GS A0A0F4GIW6_9PEZI/122-241    AC A0A0F4GIW6.1
#=GS A0A1B0G215_GLOMM/212-362    AC A0A1B0G215.1
#=GS A0A078HQ69_BRANA/161-299    AC A0A078HQ69.1
#=GS A0A3B3QN75_9TELE/109-234    AC A0A3B3QN75.1
#=GS B4G6Z1_DROPE/257-399        AC B4G6Z1.1
#=GS A0A453KBX8_AEGTS/19-111     AC A0A453KBX8.1
#=GS A0A0K9R244_SPIOL/375-508    AC A0A0K9R244.1
#=GS A0A2P8YJN3_BLAGE/86-230     AC A0A2P8YJN3.1
#=GS A0A158Q1K2_BRUMA/122-249    AC A0A158Q1K2.1
#=GS A0A397JTE5_9GLOM/432-573    AC A0A397JTE5.1
#=GS A0A084QNX5_STAC4/139-263    AC A0A084QNX5.1
#=GS V4TA91_9ROSI/181-311        AC V4TA91.1
#=GS A0A364MRX7_9PLEO/138-261    AC A0A364MRX7.1
#=GS A0A3Q3ALH8_KRYMA/138-268    AC A0A3Q3ALH8.1
#=GS A0A1A9XPA4_GLOFF/108-237    AC A0A1A9XPA4.1
#=GS A0A2T4C1V1_TRILO/407-545    AC A0A2T4C1V1.1
#=GS A0A0Q3NH81_BRADI/377-421    AC A0A0Q3NH81.1
#=GS F4WSE7_ACREC/96-221         AC F4WSE7.1
#=GS A0A1A0H244_9ASCO/574-718    AC A0A1A0H244.1
#=GS G5ALB3_HETGA/106-231        AC G5ALB3.1
#=GS W2QXN4_PHYPN/122-241        AC W2QXN4.1
#=GS G3HYQ2_CRIGR/77-159         AC G3HYQ2.1
#=GS Q5T266_HUMAN/93-175         AC Q5T266.1
#=GS A0A2Y9RAG8_TRIMA/125-249    AC A0A2Y9RAG8.1
#=GS A0A2S5B1J4_9BASI/466-614    AC A0A2S5B1J4.1
#=GS A0A261CRY6_9PELO/126-272    AC A0A261CRY6.1
#=GS W4GS94_9STRA/152-276        AC W4GS94.1
#=GS A0A287NVJ6_HORVV/362-495    AC A0A287NVJ6.1
#=GS F7C239_MONDO/82-212         AC F7C239.2
#=GS L8GEC3_ACACA/85-199         AC L8GEC3.1
#=GS F2U7J2_SALR5/144-293        AC F2U7J2.1
#=GS A0A2S7R453_9HELO/142-190    AC A0A2S7R453.1
#=GS A0A218V170_9PASE/114-238    AC A0A218V170.1
#=GS A0A087X984_POEFO/116-271    AC A0A087X984.2
#=GS A0A3N4JNP9_9PEZI/120-252    AC A0A3N4JNP9.1
#=GS D3BM84_POLPP/157-305        AC D3BM84.1
#=GS Q6BFM3_PARTE/87-237         AC Q6BFM3.1
#=GS A0A2I4GKN0_JUGRE/306-439    AC A0A2I4GKN0.1
#=GS H3B259_LATCH/28-129         AC H3B259.1
#=GS G8C2D6_TETPH/103-231        AC G8C2D6.1
#=GS A0A2U4BGW8_TURTR/121-247    AC A0A2U4BGW8.1
#=GS V5GK22_KALBG/186-315        AC V5GK22.1
#=GS A0A286UC54_9AGAM/160-287    AC A0A286UC54.1
#=GS A0A1G4MK26_LACFM/124-242    AC A0A1G4MK26.1
#=GS A0A2T7D2I5_9POAL/170-300    AC A0A2T7D2I5.1
#=GS A0A0K3CNN8_RHOTO/272-402    AC A0A0K3CNN8.1
#=GS C3XRY7_BRAFL/91-213         AC C3XRY7.1
#=GS Q23E77_TETTS/454-602        AC Q23E77.1
#=GS T0M4E0_COLGC/256-393        AC T0M4E0.1
#=GS A0A067LVS3_9AGAM/647-777    AC A0A067LVS3.1
#=GS A0A3L6RE34_PANMI/156-286    AC A0A3L6RE34.1
#=GS A0A3B5BFQ9_9TELE/85-218     AC A0A3B5BFQ9.1
#=GS A0A287NVZ1_HORVV/174-245    AC A0A287NVZ1.1
#=GS A0A0N1PJD9_PAPMA/135-289    AC A0A0N1PJD9.1
#=GS W4G682_9STRA/388-508        AC W4G682.1
#=GS A0A3P9DHU2_9CICH/138-267    AC A0A3P9DHU2.1
#=GS A0A1S3DXL1_CICAR/124-211    AC A0A1S3DXL1.1
#=GS Q16ED5_AEDAE/53-179         AC Q16ED5.1
#=GS U3J0F7_ANAPP/85-218         AC U3J0F7.2
#=GS A0E269_PARTE/225-330        AC A0E269.1
#=GS B3M459_DROAN/101-245        AC B3M459.2
#=GS G7PSC3_MACFA/85-218         AC G7PSC3.1
#=GS A0A2K5LL41_CERAT/251-385    AC A0A2K5LL41.1
#=GS S7Z8W0_PENO1/404-533        AC S7Z8W0.1
#=GS A0A024GGW6_9STRA/118-242    AC A0A024GGW6.1
#=GS A0A1V8V927_9PEZI/436-576    AC A0A1V8V927.1
#=GS B3RWP2_TRIAD/126-212        AC B3RWP2.1
#=GS A0A1A6GVZ5_NEOLE/2-128      AC A0A1A6GVZ5.1
#=GS A0A0D2DCI1_9EURO/136-265    AC A0A0D2DCI1.1
#=GS A0A068RV42_9FUNG/146-278    AC A0A068RV42.1
#=GS A0A0L7QNI7_9HYME/88-232     AC A0A0L7QNI7.1
#=GS A0A2G5E2P5_AQUCA/116-178    AC A0A2G5E2P5.1
#=GS A0A0F7TNC2_9EURO/125-254    AC A0A0F7TNC2.1
#=GS A4HV16_LEIIN/365-494        AC A4HV16.1
#=GS A0A3Q1J596_ANATE/133-262    AC A0A3Q1J596.1
#=GS A0A0L6V3P3_9BASI/114-151    AC A0A0L6V3P3.1
#=GS A0A401P8H0_SCYTO/162-287    AC A0A401P8H0.1
#=GS A0A3B3SVH6_9TELE/153-277    AC A0A3B3SVH6.1
#=GS F1STS0_PIG/184-313          AC F1STS0.3
#=GS G3SRY6_LOXAF/130-259        AC G3SRY6.1
#=GS A0A225WTN9_9STRA/109-236    AC A0A225WTN9.1
#=GS A0A2I3MWH8_PAPAN/121-237    AC A0A2I3MWH8.1
#=GS A0A0V1P265_9BILA/123-261    AC A0A0V1P265.1
#=GS A0A317X176_9EURO/125-256    AC A0A317X176.1
#=GS F7GGL9_MACMU/151-305        AC F7GGL9.1
#=GS A0A2C9JX08_BIOGL/95-239     AC A0A2C9JX08.1
#=GS A0A016U7S7_9BILA/101-233    AC A0A016U7S7.1
#=GS A0A3B5Z0T8_WHEAT/136-179    AC A0A3B5Z0T8.1
#=GS A0A093X892_9PEZI/452-585    AC A0A093X892.1
#=GS A0A0N4U838_DRAME/221-345    AC A0A0N4U838.1
#=GS A0A2R8ZK23_PANPA/125-249    AC A0A2R8ZK23.1
#=GS G1MB86_AILME/106-232        AC G1MB86.1
#=GS A0A2J6M1P4_LACSA/161-285    AC A0A2J6M1P4.1
#=GS Q5CWL9_CRYPI/91-232         AC Q5CWL9.1
#=GS A0A1U8N049_GOSHI/134-264    AC A0A1U8N049.1
#=GS A0A067G1B9_CITSI/373-505    AC A0A067G1B9.1
#=GS A0A261C0I3_9PELO/163-291    AC A0A261C0I3.1
#=GS C5XVY1_SORBI/92-218         AC C5XVY1.1
#=GS A0A2I1CHP1_9EURO/171-294    AC A0A2I1CHP1.1
#=GS A0A0V0UWQ9_9BILA/129-258    AC A0A0V0UWQ9.1
#=GS A0A251N593_PRUPE/161-288    AC A0A251N593.1
#=GS A0A3B4APH8_9GOBI/119-244    AC A0A3B4APH8.1
#=GS A0A0S3RAH0_PHAAN/143-284    AC A0A0S3RAH0.1
#=GS A0A1R3IMB8_9ROSI/126-253    AC A0A1R3IMB8.1
#=GS A0A317XK00_9BASI/646-791    AC A0A317XK00.1
#=GS F9FTH8_FUSOF/82-215         AC F9FTH8.1
#=GS A0A2K5SIY5_CEBCA/105-255    AC A0A2K5SIY5.1
#=GS A0A2K5XUU3_MANLE/130-286    AC A0A2K5XUU3.1
#=GS A0A0K0F927_STRVS/100-225    AC A0A0K0F927.1
#=GS A0A0D2ULU9_CAPO3/107-232    AC A0A0D2ULU9.1
#=GS A0A1U8KPJ7_GOSHI/160-284    AC A0A1U8KPJ7.1
#=GS A0A2U4A5T1_TURTR/90-195     AC A0A2U4A5T1.1
#=GS A0A1X6MNK3_9APHY/230-354    AC A0A1X6MNK3.1
#=GS A0A4D8YRV2_SALSN/183-313    AC A0A4D8YRV2.1
#=GS H0XNC7_OTOGA/426-562        AC H0XNC7.1
#=GS A0A484B729_DRONA/206-429    AC A0A484B729.1
#=GS A0A091J8R0_EGRGA/85-218     AC A0A091J8R0.1
#=GS A0A3Q7SBM1_VULVU/121-259    AC A0A3Q7SBM1.1
#=GS G7KW72_MEDTR/146-276        AC G7KW72.1
#=GS Q9W345_DROME/94-219         AC Q9W345.4
#=GS G0NN84_CAEBE/164-293        AC G0NN84.1
#=GS A0A287NV67_HORVV/12-145     AC A0A287NV67.1
#=GS K8EZZ7_9CHLO/405-529        AC K8EZZ7.1
#=GS I1PQU9_ORYGL/68-223         AC I1PQU9.1
#=GS A0A368PHN0_SETIT/379-512    AC A0A368PHN0.1
#=GS A0A3B4XGD3_SERLL/118-244    AC A0A3B4XGD3.1
#=GS A0A0E0IXU0_ORYNI/180-268    AC A0A0E0IXU0.1
#=GS A0A0V1I899_9BILA/152-279    AC A0A0V1I899.1
#=GS A0A2U4CA88_TURTR/126-255    AC A0A2U4CA88.1
#=GS M4CTL9_BRARP/120-249        AC M4CTL9.1
#=GS A0A163KEP9_ABSGL/139-179    AC A0A163KEP9.1
#=GS F1S5J9_PIG/94-244           AC F1S5J9.2
#=GS A0A1U7SEI9_TARSY/129-258    AC A0A1U7SEI9.1
#=GS A0A0X3PXT0_SCHSO/79-224     AC A0A0X3PXT0.1
#=GS G3PHN6_GASAC/72-199         AC G3PHN6.1
#=GS A0A3Q7GPZ3_SOLLC/166-325    AC A0A3Q7GPZ3.1
#=GS A0A251S7F5_HELAN/148-279    AC A0A251S7F5.1
#=GS A0A443I120_BYSSP/127-256    AC A0A443I120.1
#=GS A0A199UTI0_ANACO/92-220     AC A0A199UTI0.1
#=GS A0A1U7R9G3_ALLSI/78-203     AC A0A1U7R9G3.2
#=GS A0A3B4TB64_SERDU/173-297    AC A0A3B4TB64.1
#=GS A0A2K6D593_MACNE/121-247    AC A0A2K6D593.1
#=GS W4G569_9STRA/401-435        AC W4G569.1
#=GS A0A182ESF1_ONCOC/192-234    AC A0A182ESF1.1
#=GS A0A2T7CJS9_9POAL/156-286    AC A0A2T7CJS9.1
#=GS G1T9U3_RABIT/97-217         AC G1T9U3.1
#=GS A0A2C9K0F7_BIOGL/396-532    AC A0A2C9K0F7.1
#=GS A0A2K5PTS4_CEBCA/134-256    AC A0A2K5PTS4.1
#=GS A0A0C3BX61_9AGAM/238-360    AC A0A0C3BX61.1
#=GS T0QIJ0_SAPDV/99-220         AC T0QIJ0.1
#=GS PFA5_YEAST/126-252          AC Q03289.1
#=GS Q5CYP3_CRYPI/98-238         AC Q5CYP3.1
#=GS A0A1U7TKN5_TARSY/134-263    AC A0A1U7TKN5.1
#=GS A0A3B3VEG0_9TELE/424-560    AC A0A3B3VEG0.1
#=GS A0A1R3RB51_ASPC5/125-256    AC A0A1R3RB51.1
#=GS A0A1V9ZAB0_9STRA/606-721    AC A0A1V9ZAB0.1
#=GS A0A0S3TAG1_PHAAN/134-265    AC A0A0S3TAG1.1
#=GS A0A0V0ZYL2_9BILA/105-236    AC A0A0V0ZYL2.1
#=GS G8BBB1_CANPC/98-226         AC G8BBB1.1
#=GS A0A484E8L7_BRELC/428-548    AC A0A484E8L7.1
#=GS A0A182JEJ9_9DIPT/92-223     AC A0A182JEJ9.1
#=GS G9NUQ2_HYPAI/446-576        AC G9NUQ2.1
#=GS W5JDF1_ANODA/375-493        AC W5JDF1.1
#=GS F6VHI5_MACMU/251-385        AC F6VHI5.2
#=GS A0A1F5LRM1_9EURO/124-253    AC A0A1F5LRM1.1
#=GS A0A427XN97_9TREE/431-574    AC A0A427XN97.1
#=GS A0A317VXF7_ASPEC/86-219     AC A0A317VXF7.1
#=GS I0FVS9_MACMU/93-218         AC I0FVS9.1
#=GS A0A498KMJ7_MALDO/193-322    AC A0A498KMJ7.1
#=GS A0A180H5C0_PUCT1/109-308    AC A0A180H5C0.1
#=GS E6ZXV1_SPORE/410-539        AC E6ZXV1.1
#=GS ZDH18_HUMAN/187-316         AC Q9NUE0.2
#=GS H2ZYS6_LATCH/373-509        AC H2ZYS6.1
#=GS A0A2T2NE29_CORCC/86-219     AC A0A2T2NE29.1
#=GS A0A1X2HF20_SYNRA/94-227     AC A0A1X2HF20.1
#=GS A0A3Q7WH54_URSAR/160-289    AC A0A3Q7WH54.1
#=GS A0A0D3GJ75_9ORYZ/365-498    AC A0A0D3GJ75.1
#=GS C4LXJ0_ENTHI/149-292        AC C4LXJ0.1
#=GS A0A0D3DUQ2_BRAOL/120-249    AC A0A0D3DUQ2.1
#=GS A0A0D2RE81_GOSRA/160-284    AC A0A0D2RE81.1
#=GS A0A0L8FYF5_OCTBM/89-232     AC A0A0L8FYF5.1
#=GS A0A402G2E3_9SAUR/24-74      AC A0A402G2E3.1
#=GS A8BAE2_GIAIC/122-245        AC A8BAE2.1
#=GS Q8SVX7_ENCCU/107-230        AC Q8SVX7.1
#=GS H2Y7Z6_CIOSA/123-249        AC H2Y7Z6.1
#=GS A0A2Y9NJJ4_DELLE/85-218     AC A0A2Y9NJJ4.1
#=GS A0A2T7D1K0_9POAL/152-308    AC A0A2T7D1K0.1
#=GS A0A4D9DUZ9_9SAUR/99-224     AC A0A4D9DUZ9.1
#=GS A0A1W4WZ29_AGRPL/113-180    AC A0A1W4WZ29.1
#=GS ZDH15_DANRE/118-244         AC F1QXD3.1
#=GS ZDH15_DANRE/118-244         DR PDB; 6BMS D; 112-238;
#=GS ZDH15_DANRE/118-244         DR PDB; 6BMS A; 108-234;
#=GS A0A2H0ZW67_CANAR/474-618    AC A0A2H0ZW67.1
#=GS A0A3B6CGE5_WHEAT/155-309    AC A0A3B6CGE5.1
#=GS A0A509AKG7_PLABA/426-551    AC A0A509AKG7.1
#=GS A0A1E3I0D0_9TREE/411-540    AC A0A1E3I0D0.1
#=GS A0A3P7J6T7_ANGCS/100-248    AC A0A3P7J6T7.1
#=GS W5NJK9_LEPOC/130-237        AC W5NJK9.1
#=GS A0A078J6G9_BRANA/160-298    AC A0A078J6G9.1
#=GS A0A3N4HPK5_ASCIM/151-296    AC A0A3N4HPK5.1
#=GS A0A072PVE5_9EURO/432-573    AC A0A072PVE5.1
#=GS A0A2G3DDT7_CAPCH/122-251    AC A0A2G3DDT7.1
#=GS B4FAG9_MAIZE/139-270        AC B4FAG9.1
#=GS A0BYH1_PARTE/4-83           AC A0BYH1.1
#=GS A0A074SN87_HAMHA/164-291    AC A0A074SN87.1
#=GS B4FDI4_MAIZE/145-269        AC B4FDI4.1
#=GS A0A068V6A4_COFCA/40-172     AC A0A068V6A4.1
#=GS A0A1U7QAL8_MESAU/248-382    AC A0A1U7QAL8.1
#=GS F0X9U0_GROCL/154-310        AC F0X9U0.1
#=GS A0A251QJ42_PRUPE/18-145     AC A0A251QJ42.1
#=GS F1S5W3_PIG/129-258          AC F1S5W3.1
#=GS A0A445BCK2_ARAHY/162-286    AC A0A445BCK2.1
#=GS A0A1E4RPG8_9ASCO/97-225     AC A0A1E4RPG8.1
#=GS Q2QQX2_ORYSJ/147-271        AC Q2QQX2.1
#=GS A0A091GDV6_9AVES/71-196     AC A0A091GDV6.1
#=GS A0A2I3M3K0_PAPAN/151-289    AC A0A2I3M3K0.1
#=GS A0A3P8XNP1_ESOLU/126-255    AC A0A3P8XNP1.1
#=GS A0A087XYU2_POEFO/119-244    AC A0A087XYU2.1
#=GS A0A078I482_BRANA/92-220     AC A0A078I482.1
#=GS A0A3P8UA46_AMPPE/116-240    AC A0A3P8UA46.1
#=GS A0A024G190_9STRA/106-232    AC A0A024G190.1
#=GS A0A024U3U1_9STRA/100-226    AC A0A024U3U1.1
#=GS A0A3Q0GUT9_ALLSI/60-185     AC A0A3Q0GUT9.1
#=GS A0A1I8PA95_STOCA/243-375    AC A0A1I8PA95.1
#=GS A0A455BJU0_PHYMC/408-563    AC A0A455BJU0.1
#=GS A0A395S325_FUSSP/105-234    AC A0A395S325.1
#=GS A0A0V0UTA3_9BILA/133-271    AC A0A0V0UTA3.1
#=GS A0A3B4VEE3_SERDU/94-243     AC A0A3B4VEE3.1
#=GS A0A383ZNZ5_BALAS/85-218     AC A0A383ZNZ5.1
#=GS A0A194VBB1_9PEZI/452-582    AC A0A194VBB1.1
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