GenomeNet

Database: Pfam
Entry: DUF16
LinkDB: DUF16
Original site: DUF16 
#=GF ID   DUF16
#=GF AC   PF01519.16
#=GF DE   Protein of unknown function DUF16
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_764 (release 4.0)
#=GF GA   30.40 30.40;
#=GF TC   30.40 32.30;
#=GF NC   30.30 30.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Coiled-coil
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   8948633
#=GF RT   Complete sequence analysis of the genome of the bacterium
#=GF RT   Mycoplasma pneumoniae. 
#=GF RA   Himmelreich R, Hilbert H, Plagens H, Pirkl E, Li BC, Herrmann R; 
#=GF RL   Nucleic Acids Res 1996;24:4420-4449.
#=GF RN   [2]
#=GF RM   16522803
#=GF RT   Crystal structure of the DUF16 domain of MPN010 from Mycoplasma
#=GF RT   pneumoniae. 
#=GF RA   Shin DH, Kim JS, Yokota H, Kim R, Kim SH; 
#=GF RL   Protein Sci. 2006;15:921-928.
#=GF DR   INTERPRO; IPR002862;
#=GF DR   SO; 0001080; coiled_coil;
#=GF CC   The function of this protein is unknown.  It appears to only
#=GF CC   occur in Mycoplasma pneumoniae. The crystal structure revealed
#=GF CC   that this domain is composed of two separated homotrimeric
#=GF CC   coiled-coils [2].
#=GF SQ   31
#=GS Y104_MYCPN/3-103        AC P75565.1
#=GS Y501_MYCPN/39-113       AC P75286.1
#=GS Y524_MYCPN/40-125       AC P75254.1
#=GS A0A1M6CJZ4_9CLOT/2-77   AC A0A1M6CJZ4.1
#=GS Y130_MYCPN/39-139       AC P75345.1
#=GS R9MH93_9FIRM/34-128     AC R9MH93.1
#=GS Y013_MYCPN/179-256      AC P75100.1
#=GS Y410_MYCPN/39-146       AC P75374.1
#=GS Y138_MYCPN/39-157       AC P75260.1
#=GS Y100_MYCPN/110-181      AC P75592.1
#=GS Y655_MYCPN/97-195       AC P75136.1
#=GS Y287_MYCPN/2-116        AC P75490.1
#=GS Y344_MYCPN/86-194       AC P75434.1
#=GS A0A0Q5TCD4_9BACT/2-121  AC A0A0Q5TCD4.1
#=GS Y100_MYCPN/39-114       AC P75592.1
#=GS Y010_MYCPN/37-130       AC P75103.1
#=GS Y010_MYCPN/37-130       DR PDB; 2BA2 C; 205-285;
#=GS Y010_MYCPN/37-130       DR PDB; 2BA2 A; 5-85;
#=GS Y010_MYCPN/37-130       DR PDB; 2BA2 B; 106-185;
#=GS Y139_MYCPN/39-154       AC P75259.1
#=GS Y484_MYCPN/2-102        AC P75301.1
#=GS Y204_MYCPN/39-146       AC P75572.1
#=GS Y151_MYCPN/2-110        AC P75035.1
#=GS Y094_MYCPN/39-139       AC P75598.1
#=GS Y368_MYCPN/39-157       AC P75413.1
#=GS Y504_MYCPN/39-125       AC P75282.1
#=GS Y501_MYCPN/110-167      AC P75286.1
#=GS Y127_MYCPN/77-166       AC P75348.1
#=GS A0A0R2HHR2_9LACT/2-105  AC A0A0R2HHR2.1
#=GS Y038_MYCPN/29-115       AC P75076.1
#=GS Y137_MYCPN/43-170       AC P75261.1
#=GS Y013_MYCPN/108-216      AC P75100.1
#=GS Y283_MYCPN/40-115       AC P75494.1
#=GS Y145_MYCPN/37-164       AC P75141.1
Y104_MYCPN/3-103                   ....................................eldgkf----..--------....---------------....---A..........TKADLKRVED...KVDvlfelqk....tqgeqikVQGKQIEQLTETVQKQGEQIKELQVQVK....AQGEEIKeik.......veqkAQGQTLQLILKALEGINKRLDNLES.................
Y501_MYCPN/39-113                  ..........................................EFSG..KFNRQFKLnkpvIPVNTEYVTRKEFNE....YKNS..........NDQRLTKIET...TLA..................AQGEQINKLTQTVEKQGEQINQLVQ---....-------..............-------------------------vv...............
Y524_MYCPN/40-125                  ...................................elrkykl----..------KP....-PVKVKYVTQEQFQE....YKDS..........NNQRLIKIET...TLA..................AQGEQI-------RIQVEQIKELQIEQK....AQGE---..............----TLKLILQTLQKMSDRLDKME-v................
A0A1M6CJZ4_9CLOT/2-77              .......................................tdq----..--------....---------------....---D..........LQHTLNQIVG...MID..................TLGKKIDRLEEKVDRIEERLDRIEERLD....RVEERLD..............RVEERLDRVEERLDRVEARLDSLE-.................
Y130_MYCPN/39-139                  ..........................................EFSG..NFNRQFKLnkpvIPVNTEYVTRKEFNE....YKDS..........NDQRLIKIET...TLA..................AQGEQ-------IRIQGEQIKELQIEQK....AQSE---..............----TLKLILQTLQKMSDRLDKMD-vrldkles.........
R9MH93_9FIRM/34-128                ..................................leekldak----..--------....------------LQF....YMEK..........TNQRFDKLEN...KVE..................KVGQRLDSLEEKVEKVEQRLDSLEEKVE....KVEQRLDsle.......ekveKVEQRLDSLEEKVEKVEQRLDSLE-e................
Y013_MYCPN/179-256                 ........................................kq----..--------....---------------....----..........----IEQLTE...TVK..................VQGEQIRAQGEQIKAQSEEIKEIKVEQK....AQGEQIKelq.......veqkAQGKTLQLILKTLEKMNERLEKLES.................
Y410_MYCPN/39-146                  ..........................................EFSG..SFNRQFKLnkpiIPVNTEYVTRKEFNE....YKDS..........NDQRLIKIET...TLT..................AQGEQINKLTQTVEKQGEQIRELQVEQK....AQGEQIK..............AQGETLKLILQTLQKMSDRLDKID-p................
Y138_MYCPN/39-157                  ..........................................EFSG..NFNRQFKLnkpvIPVNTEYVTRKEFNE....YKDS..........NDQRLTKIEN...KVD..................KLEVKVDKLEEKVDKLEAKVDKLEEKVD....KLEAKVDkleek...vdkleaKVDSGFEMLAKILAAINKRLDSIEG.................
Y100_MYCPN/110-181                 .......................................vqv----..--------....---------------....----..........----------...-VL..................LHGEQINKLTQTVEKQGEQIKELQVEQK....AQGEQIKaqg.......kqikAQGKTLKSILQALGGINKRLDKID-p................
Y655_MYCPN/97-195                  .......................................qpg---GpdNPNAGNKK....MPTPEEYVTRKEFNE....FKDS..........NNQRLTKIEN...KVD..................KLEVKVDKLAEIVQTQGEEIKELKVEQK....AQSE---..............----TLQLILKTLQKMNDRLDRMET.................
Y287_MYCPN/2-116                   .........................................g-FSD..NLNHMEKR....---KSGYVTQKQFSE....FKDA..........NNQRLIKIET...TLA..................TQGEQLNQLIKVVILQGEQIKELQVEQK....AQGEQIKakgeqikaqseqikTQGETLKLILQALGGINKRLDKVD-p................
Y344_MYCPN/86-194                  ....................................qpggpd----..DPNSGNKK....MPKPDEFVTHRQLQE....FKKDllvelheifpTKPELKRVEE...KVD..................VLFELQKAQGEQIRIQGEQIKELKVEQK....AQGE---..............----TLQLILQTLQKMNDRLDKIEG.................
A0A0Q5TCD4_9BACT/2-121             yieeridlaeislvehgkqiemiatglatlttlvytgfaemr----..--------....---------------....----..........--EEFVQVHK...RID..................NLEIRFNKLEDKVDRLEIRIDRLEVRLD....KVEARLD..............KVEERLDKIEERLDKIEERLDKIE-arldnles.........
Y100_MYCPN/39-114                  ..........................................EFSG..SFNRQFKLnkpvIPVNTEYVTRKEFNE....YKVS..........NDQRLTKIET...TLA..................AQGEQINKLTQTVEKQGEQINQLVQ---....-------..............-------------------------vvl..............
Y010_MYCPN/37-130                  .........................................w-LKG..VFEEIVKT....-P-GTRYVTHKQLDE...kLKNF.........vTKTEFKEFQT...VVM..................---ESFAVQNQNIDAQGEQIKELQVEQK....AQGK---..............----TLQLILEALQGINKRLDNLES.................
#=GR Y010_MYCPN/37-130       SS    .........................................X-XXX..XXXXXXXX....-X-XTTB-BHHHHHH...HHTTB.........-BHHHHHHHHH...HHH..................---HHHHHHHHHHHHHHHHHHHHHHHHH....HHHH---..............----HHHHHHHHHHHHHHHHHHHC-.................
Y139_MYCPN/39-154                  ..........................................EFSG..SFNRQFKLnkpvIPVNTEYVTRKEFNE....YKDS..........NDQRLTKIET...ELK..................SQGQRIQVVEDKVDRLTEVVMVQSQQIK....TQGEAMNarmd......rfesLVLKSLESIGNTLTDFGKRLDVIET.................
Y484_MYCPN/2-102                   .........................................g-FYG..NLNHMEKR....---KSGYVTQKQFND....FKNS..........NNQRLIKIEN...TLV..................SQGEQISQLIKVSILQGEQINKLTETVE....KQGEQIQ..............TQGETLKLILETLQVINKRLDRLES.................
Y204_MYCPN/39-146                  ..........................................EFSG..KFNRQFKLnkpvITVNTEYVTRKELNE....YKDS..........NDQRLTKIET...TLA..................AQGEQINKLTQTVEKQGEQIRELQVEQK....AQGEQIK..............AQGETLKLILQTLQKMSDRLDKID-p................
Y151_MYCPN/2-110                   ..........................................EFNG..NLNHMEKR....---KSGYVTQKQFNE....YKDS..........NDQRLIKIET...TLA..................AQGEQISQLVQIVFLQGKQIKELQAEQK....AQRVEFNarmd......rfesLVLKSLESIGNTLTDFGKRFDSMET.................
Y094_MYCPN/39-139                  ..........................................EFSG..NFNRQFKLnkpvIPVNTEYVTRKEFNE....YKDS..........NDQRLTKIET...TLA..................AQGEQ-------IRIQGEQIKELQIEQK....AQGETLK..............LILQTLQKMSDRLNKMDVRLDKLE-s................
Y368_MYCPN/39-157                  ..........................................EFSG..SFNRQFKLnkpvIPVNTEYVTRKEFNE....YKDS..........NDQRLTKIEN...KVD..................KLEIKVDKLEKKVDKLEVKVDKLVETVN....AQGEDLNnfkve...vrgtlqSQGETLQLILQTLQGMSKRLDSVEG.................
Y504_MYCPN/39-125                  ..................................yelrkykl----..------KP....-PVKVKYVTQEQFQE....YKDS..........NNQRLIKIEN...KVD..................-------KLVEIVQIHGEQI-------K....AQGE---..............----TLQLILQTLQKMSDRLDKME-kridkles.........
Y501_MYCPN/110-167                 .......................................vqv----..--------....---------------....----..........----------...-VL..................LHGEQINKLTQTVEKQGEQIKELQIEQK....AQGE---..............----TLKLILQTLQKMSDRLDKME-v................
Y127_MYCPN/77-166                  .........................................g-FNG..NFNHMEKR....---KSGYVTQKQFSE....FKDA..........NNQRLIKIET...TLA..................IQGEQINKLTQTVEKQGEQINQLVQVVL....LQGA---..............-------------------------sklenfkwskkhkdksl
A0A0R2HHR2_9LACT/2-105             ...................................tandamp----..--------....IPSPPDWVTQKEFQE....FKTE..........VKQNFKQIDRqfvRID..................QQFVRIDQQFKLIDIQFGKVNNRLDRIDdrldVMEKNFA..............VHEKSFKMMEKNFQTMEK-------nsdlr............
Y038_MYCPN/29-115                  .........................................g-FHG..NLNHMEKG....---KSGYVTHKQLDKklevFKQ-..........---DL-----...LVE..................-LSEKF-VTKEEFRAQGKQIKELQIEQK....AQGK---..............----TLQLILEALQGINKRLDKLES.................
Y137_MYCPN/43-170                  .........................................s-FNG..DFEVVTKK....-P-STKYVTHKQLDQklkeFKQDlmvelhdtfaTKADLRDSEA...RINqklea.......lvqvvlLHGEQINKLTQIVEKQGEQIRELQVEQK....AQRQEFN.............aRMDRLENLLVESIESTNKRFDSIEG.................
Y013_MYCPN/108-216                 ..................................pggpddps----..---EGKQK....VSKPDKYVTHRELDE...kLK-Df........aTKADFKRVED...KVDvlf...........elqkTQGEQIKVQGEQIKAQGKQIEQLTETVK....VQGEQIR..............AQGEQIKAQSEEIKEI---------kveq.............
Y283_MYCPN/40-115                  ...................................elrkykl----..------KP....-PVKVKYVTQEEFGE....FKDA..........TNQRLTKIEN...ALV..................AQGEQIRAQGEQLSQLIKVVLLQGEQIK....SQGEQIK..............-------------------------s................
Y145_MYCPN/37-164                  .........................................s-LNG..VFEEIVKT....-PGKTRYVTHKQLDQklkdFKQDlmvelhdtfaTKTDLKESEA...RINqklealiqivmvqgeqikVHGEQINKLTQAVEKQGEKI-------E....AQGQQIQ..............KVNETLNFVVESLGSIHKRLDSMEG.................
#=GC SS_cons                       .........................................X-XXX..XXXXXXXX....-X-XTTB-BHHHHHH...HHTTB.........-BHHHHHHHHH...HHH..................---HHHHHHHHHHHHHHHHHHHHHHHHH....HHHH---..............----HHHHHHHHHHHHHHHHHHHC-.................
#=GC seq_cons                      ..................................................pt..Kh.....s.pscYVTpKphsE....aKss..........spQcLp+IEs...pls..................spGEQIspLtppVctQGEQIccLp.c.K....AQGEphp.................poLphIhpsLpphscRLDphE..................
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