GenomeNet

Database: Pfam
Entry: DUF2118
LinkDB: DUF2118
Original site: DUF2118 
#=GF ID   DUF2118
#=GF AC   PF09891.9
#=GF DE   Uncharacterized protein conserved in archaea (DUF2118)
#=GF AU   COGs;
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   COGs (COG4072)
#=GF GA   20.50 20.50;
#=GF TC   20.50 20.50;
#=GF NC   20.40 20.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR019217;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This domain, found in various hypothetical archaeal proteins,
#=GF CC   has no known function.
#=GF SQ   39
#=GS B8D6F0_DESA1/4-152       AC B8D6F0.1
#=GS Q9YB32_AERPE/20-168      AC Q9YB32.1
#=GS A0A075LQD5_9EURY/2-163   AC A0A075LQD5.1
#=GS F8AHU2_PYRYC/2-164       AC F8AHU2.1
#=GS A0A0U3EEE1_9CREN/4-149   AC A0A0U3EEE1.1
#=GS A2BK90_HYPBU/13-160      AC A2BK90.1
#=GS D3LV55_9FIRM/20-96       AC D3LV55.1
#=GS D7DV81_METV3/5-160       AC D7DV81.1
#=GS B6YUI5_THEON/2-163       AC B6YUI5.1
#=GS F6BEB9_METIK/1-152       AC F6BEB9.1
#=GS G0HKK4_THES4/2-163       AC G0HKK4.1
#=GS A3DMR4_STAMF/4-160       AC A3DMR4.1
#=GS A0A256ZTA2_9CREN/11-170  AC A0A256ZTA2.1
#=GS C6A019_THESM/2-163       AC C6A019.1
#=GS A0A218P355_THECE/2-163   AC A0A218P355.1
#=GS Q8TXA2_METKA/1-162       AC Q8TXA2.1
#=GS A0A256Z7X1_9CREN/4-140   AC A0A256Z7X1.1
#=GS A8ABP2_IGNH4/4-149       AC A8ABP2.1
#=GS Q6M171_METMP/1-150       AC Q6M171.1
#=GS Q6M171_METMP/1-150       DR PDB; 3D4R D; 1-150;
#=GS Q6M171_METMP/1-150       DR PDB; 3D4R B; 1-150;
#=GS Q6M171_METMP/1-150       DR PDB; 3D4R E; 1-150;
#=GS Q6M171_METMP/1-150       DR PDB; 3D4R A; 1-150;
#=GS Q6M171_METMP/1-150       DR PDB; 3D4R F; 1-150;
#=GS Q6M171_METMP/1-150       DR PDB; 3D4R C; 1-150;
#=GS D5VSA2_METIM/1-151       AC D5VSA2.1
#=GS A0A100XWS7_9EURY/2-163   AC A0A100XWS7.1
#=GS A0A0V8RTM4_PYROC/12-160  AC A0A0V8RTM4.1
#=GS Q8U1K5_PYRFU/2-163       AC Q8U1K5.1
#=GS A0A1Z2TPV0_9EURY/2-163   AC A0A1Z2TPV0.1
#=GS G0EE93_PYRF1/11-160      AC G0EE93.1
#=GS A0A218P613_9EURY/2-163   AC A0A218P613.1
#=GS W0I544_9EURY/2-164       AC W0I544.1
#=GS D5U3E6_THEAM/4-158       AC D5U3E6.1
#=GS A0A0P0N5J5_9CREN/13-161  AC A0A0P0N5J5.1
#=GS Q5JEN4_THEKO/2-163       AC Q5JEN4.1
#=GS A0A117KPA8_9EURY/2-163   AC A0A117KPA8.1
#=GS A0A256YG67_9CREN/4-156   AC A0A256YG67.1
#=GS A0A160VT47_9EURY/2-164   AC A0A160VT47.1
#=GS C5A383_THEGJ/2-163       AC C5A383.1
#=GS Y859_METJA/4-156         AC Q58269.1
#=GS R7PSJ1_9FIRM/21-94       AC R7PSJ1.1
#=GS O58980_PYRHO/20-181      AC O58980.1
#=GS I0A0D6_FERFK/6-145       AC I0A0D6.1
#=GS E0SQA2_IGNAA/15-153      AC E0SQA2.1
B8D6F0_DESA1/4-152                  ...................................................................................YSFPQLFVEDVDSE................--RIICLKNSEYA..wAG.I..PEK......N.NCTKYY...GSIP........Y.EE-ILKYID.LEKAIL.K.RSTILFNT...gEPSKALFFSENT.QLCLQEAKG.RRVFYIGSM-KHVRKNDLIAYIVTGKNEVRNIYSTCEGFILAVIDLTW...ERPERIIVVVA--ie........................
Q9YB32_AERPE/20-168                 ...................................................................................YRFPELYLEGYVSE................---RAIWVDEEEG...KY.Y..RRP......V.EGLKRY...GLAV........Y.EHAIKEAID.LVGSRV.S.RGFVVVIP...wKGMRGLMLREGT.RVKLVEAAG.VQVSHYSLEGTRVGERSVLSYVLTGKGETRTLRAGVEGVVAIILTDHN...RQPPAYIYVIADE..........................
A0A075LQD5_9EURY/2-163              ..................................................................................e-KMPMLFVEKSYDEcfeeeka.kneciiiqDNIEVKLSKGDKL...PN.F..IDK......N.KAKFLT...-KEV........Y.DR-FHLYVD.KNEMKM.L.RDAIIVLP....GRRTQIKLKKGD.KLMILPVEG.FVSTLIAGVGNRVRKSDAFAAVTTKKGEVHYLKPPKSGVVVYIDEFTN...--RPHYLYYLLPE..........................
F8AHU2_PYRYC/2-164                  ..................................................................................r-RLPQLFVEASYEEcfdeegkakvdciviqGNVEVRMRKGEKL...PA.F..IDP......K.EAKFLA...-KEV........Y.DR-FHFYVD.QYEHRM.R.VDAIIVLP....DRRTEIRLQKGD.ELLLLPVEG.YVVTLIADVGNRVRTGDAFAAVTTRKGEVHYMKPPKPGVVVYIDEFTN...--RPNYVYYILPE..........................
A0A0U3EEE1_9CREN/4-149              ...................................................................................YEFPKLFVEGIDGE................----EYLEITDNS...AK.I..SKE......P.SSPK-L...GKVP........L.EIDLEEIVD.LLGERV.K.RSFAVYNP....RKKVVIYVREGT.PIKILRVDH.KKVLIELSEGDEINLDSTYAHGITSKGEYRRFRSKVKGIVVLVHWKPL...GGRDIYHVIVAE-r.........................
A2BK90_HYPBU/13-160                 ...................................................................................YHIPRIYIEGIGSD................----EYLELVDST...AR.R..TDR......C.SGRRCF...GKAI........Y.GTLLDEIAD.LLAKKA.T.RSFIVVLP...pDYRKGLLVEAGS.YLEPVPLEG.MRVVIHVCEGDRVEEGSTLGFIATRKFEVRHIRSHVEGVVVYIYSSPE...GPPDRNIVFIAPE..........................
D3LV55_9FIRM/20-96                  ....................................................................tpvmaeevscasvlt--------------................-------------...--.-..---......-.------...----........-.---------.------.-.--------....------------.---------.GTVVSVAAVGTQVKEGDVLLTVASLAGPMPAIRAQRDGVVKVVKTAPG..aEVQQGAAVIIV--de........................
D7DV81_METV3/5-160                  ...................................................................................MKIPKLYVENNIFEd..............nEPCEKIAVSEKEI...IF.LdsDEV......V.DNYKNT...HKIL........Y.KVRYDDIRS.YIDNDVlK.KDIFVKYP....GNHTFTHIKAGT.YITCVLADS.KTTYPILDAGSVVLRDGILATLKSNKGVIRYLKSPVSGTVFFMNEIFE...GNNSIYLFAIVE-n.........................
B6YUI5_THEON/2-163                  ..................................................................................e-KMPKLYVEVPKEGciennka.srdcliimNNVEVWLRKGESV...PE.F..IDV......E.KAKFLA...-KEV........Y.DR-FYLHVD.RLKGRM.E.VDAVLVLP....DGRTRIYLRKGD.ELLLLPVEG.YTKTLIANVGNRVRTGDAFAAVTTKKGEVHYLKPPKTGTVVFIDEITN...--RPHYVYYILPE..........................
F6BEB9_METIK/1-152                  ...................................................................................MKIPRLYVEGETEK...............nEGRKVVIENDGKV...IR.F..LDE......D.EEYEGE...GKVL........Y.QVIYDDFDKyILLSKL.T.RDVLIQYP....DKRTITYLKKGT.ELLEIPAEG.YEVHPIVDFGCRVLEGHRLAALVTKKGEIRFVNTPVTGTVVFMKEVPA...-KRANYVFYILPE..........................
G0HKK4_THES4/2-163                  ..................................................................................e-KMPRLYVEAPAEEcikdgkv.trdcviiqGSVEVWLRKDEGV...PD.F..VEA......E.KAKFLA...-KEV........Y.DR-FYMYVD.GTEGRM.L.ADAVLILP....DGRTRIYLKKGD.ELLILPVEG.YTKTIIANVGNRVRRGDAFAAVTTKKGEVHYLKPPKTGTVVFIDEITN...--RPHYVYYILPE..........................
A3DMR4_STAMF/4-160                  ...................................................................................YRYPEVFVEGVESD................---KYVLEINEHY...IL.V..LTKedlekyV.NYKRVF...GHII........Y.EH-IINYID.LVKPAT.K.KAFIVIPEysgeKEMNGFLIDENK.KLCLIEVKG.IQPYVFPREGDEIEERDKVAYIITGKGEVRTIRSPCKGVVLLVINFPW...EKPEKYVLAVV--nk........................
A0A256ZTA2_9CREN/11-170             ...................................................................................YNYPQIYVEEDKDKi..............dPGSKVIFEKNDRT...FC.L..VKY......D.REEVFK...GNVVkrlfaskpY.ETAYEEIVD.LEKAEI.T.KSFIVYAP....KRKTYILVEKGS.NVQLLDIVG.LKIFLAIEEGDRVKEGDIIGYQVTGKFEVRNIISNGEGVVAYIGTVFE...-EIQHYIVVLVG-e.........................
C6A019_THESM/2-163                  ...................................................................................EKIPQLFVESNLEEcvdgeka.rvdcriiqDNIEVKVKKGEKI...PE.F..IDP......K.RAKFMK...-KEV........Y.DR-FHFYVD.KYEHKM.M.CNAIIILP....DRRTEIRLYKGD.ELMLLPVEG.YVSSIIAGVGNRVRKSDAFAAITTKKGEVHYLKPPKTGVVVYIDEFTN...--RPHYVYYILPE..........................
A0A218P355_THECE/2-163              ...................................................................................EKIPRLYVEVSPDEcikegrv.trdcviisGNVEVWVRENEAV...PE.F..VDT......K.KAKV-L...GKEV........Y.DR-FYLYVD.RTEGKM.I.KDAILVLP....DGRTRIHLKKGD.ELMLLPVEG.YTKTLIANVGNRVRKGDAFAAVTTRKGEVHYLKPPKTGTVVFIDEVTN...--SPHYVYYILPE..........................
Q8TXA2_METKA/1-162                  ...................................................................................MALPRIYVETDEVPesgk.......illtdPEFEVIVRSRELA...EK.I..AEE......L.DEPIFY...EQVV........Y.EE-ARSVFD.VPEAKV.T.RHVVIEPV....DRRSLVFLKPGD.RVYQIPVEG.YVVTPIADVGDRLRKGDPLAAVTTRSGNVRYVEAPQDCLVVYVCEQPAirtQRRPNYEYYIAPT..........................
A0A256Z7X1_9CREN/4-140              ............................................katkkvldelkrlqhaykptkcylisdefkeeidcvvla--------------................-------------...--.-..---......-.------...----........-.--------N.KLYHKVlD.KDFLICNE....RLSRCYRISKDS.KLECIEVMG.HDVYMLKDELEDVDVNERISYIVTNKGEVRSIRSPYKGKILLIHEVLG...EKYSHYRIFI---ev........................
A8ABP2_IGNH4/4-149                  ...................................................................................YKFPRLFVEGKEGE................---EYAVVEGDEV...VF.V..KEK......V.PGAL--...GKVP........Y.EIPLDEIVD.KLKEEA.K.VTFLIHLP....NEDKAILVPKGS.KVKLFKVSH.VKVGVTVKEGDELEEGDTYAYGLTGKGEVRRFRSIVKGKVVMVHWEPY...GGRDDYHVLVVPE..........................
Q6M171_METMP/1-150                  ...................................................................................MKIPKIYVEGELND................-GDRVAIEKDGNA...II.F..LEK......D.EEYSGN...GKLL........Y.QVIYDDLAKyMSLDTL.K.KDVLIQYP....DKHTFTYLKAGT.KLISVPAEG.YKVYPIMDFGFRVLKGYRLATLESKKGDLRYVNSPVSGTVIFMNEIPS...-ERANYVFYMLEE..........................
#=GR Q6M171_METMP/1-150       SS    ...................................................................................SE--EEEEET--SS................-S-EEEEEGGGTE...EE.E..E-T......T.----SS...SEEE........E.EESSS-GGGGEETTEE.S.S-EEEEET....TSSEEEEE-TT-.B-EEEEEES.SEEEESS-TSEEE-TT-EEEEEE-TTS-EEEEE-SSSEEEEEEEEETT...-CEEEEEEEEEE-..........................
D5VSA2_METIM/1-151                  ...................................................................................MRIPKLYVEGEEGE................--EKVVIEKDGKI...IR.F..LDK......G.ESYEGE...GKVL........G.KVIYDDFPNyILMGEA.T.RDMLIVYEv..gGLKKIMYLKKGT.KLLEVPAEG.YKVYPIVDHGCRILEGHRLAALQSRKGDIRFVNTPVNGIVVFLREVPC...-KRENYVFYILPD..........................
A0A100XWS7_9EURY/2-163              ..................................................................................e-KMPRLYVEVPPEEcikggkv.trdcviiqGSVEVWLRKDEGV...PD.F..VEA......E.RAKFLA...-KEV........Y.DR-FYLYVD.GTEGRM.L.ADAILILP....DGRTRIYLKKGD.ELLILPVEG.YTKTIIANVGNRVRRGDAFAAVTTKKGEVHYLKPPKTGTVVFIDEITN...--RPHYVYYILPE..........................
A0A0V8RTM4_PYROC/12-160             ..................................................................................y-LIPQLFIEGLESS................---DYLVLRNGVA...QR.S..RGC......P.EGERCF...GKAI........Y.GVELESIVD.LVAKKS.R.RSFIVVLP...rEYRRGLLVEAGS.PVEPIPLEG.MRVVLEVCEGSRVGVQSTLGFIATRKLEVRRIRSHVKGVVVYIYSSPE...AGPDKNIVLVAPE..........................
Q8U1K5_PYRFU/2-163                  ..................................................................................s-RTPQLYVEVPKEEclegrrv.khdciviqDNIEVRLREGEEV...PE.F..IQV......D.KAKFLA...-KEI........Y.DR-FHFYVD.HYEHRM.K.VDAIIVYP....DRRTKIYLKKGD.ELLLLPVEG.YVVTLIADVGNRVRKGDAFAAVTTRKGEVHYLKPPKPGTVVYIDEFTN...--RPHYIYYILPE..........................
A0A1Z2TPV0_9EURY/2-163              ..................................................................................e-RVPRLYVEAPPEEclegrkv.kkdcvvisGNVEVWLKRDESV...PD.F..IEI......E.GAKF-L...AKEV........Y.DR-FYLYVD.RMEGKM.L.ADAILALP....DGRTRIYLKRDD.ELLILPVEG.YTKTLIANVGNRVRTGDAFAAITTRKGEVHYLKPPKTGTVVFIDEVTN...--RPHYVYYILPE..........................
G0EE93_PYRF1/11-160                 ..................................................................................y-LIPRLYIEGIKGD................---EYLVESGEGV...YK.R..SKS......CpSGSRCY...GKAI........Y.GVELDSILD.LLEKKV.K.RSFIVEPG...dKPGEGILVESGV.HAEPIPVSG.KRAVIEVLEGDEVKEGDVLGLIVTGKYELRKVRSHVDGIVVYIYSSPM...GPPDENIVFIVP-r.........................
A0A218P613_9EURY/2-163              ..................................................................................e-RMPRLYVEVDAGEcvvqgka.trdcviiqGNIEVWLEEGDEL...PE.F..IDL......E.DAKFLA...-KEV........Y.DR-FYLYVD.RMEGRM.L.ADVVLVLP....DGRTRIYLKKGD.ELMILPVEG.YTKTIIANVGNRVRKGDAFAAVTTRKGEVHYLKPPKTGTVVFIDEITD...--RPHYVYYILPE..........................
W0I544_9EURY/2-164                  ...................................................................................ERIPQLYVESSYEEcfdkdgkakvdciiiqDNIEVRLKKGERI...PE.F..IDR......E.KAKILR...-KEV........Y.DR-FHFYVD.KYEHKM.L.CDAIIVLP....DRRTEIRLYKGD.ELMILPVEG.YVSTLIAGVGNRVRKSDAFAAVTTKKGEVHYLKPPKSGVVVFIDEFTN...--RPHYLYYLLPE..........................
D5U3E6_THEAM/4-158                  ..................................................................................y-FFPEAYVENGLES................-GRSICFKGNDIY...IA.F..AKN......A.GTGECVktfVNTP........F.EK-LVEYMD.LEKPCF.T.RDVIIVHRe.egGYYKGFLIEKGE.KLYLLEASG.STIAVSKREGDAVEPHEKIGYIITNKREVRVIKAPLKGILLAVIDLTW...EKPEKIIM-----vftge.....................
A0A0P0N5J5_9CREN/13-161             ..................................................................................y-LIPQLFIEGLDSD................----EFLVLRDSI...AK.R..SME......CpKDARCF...GKAI........Y.GVELDSIVD.LVAKKC.T.RSFIVVLP...pDYRRGLLVEAGS.YVEPIPLEG.MRVAVEVCEGSKVGIEDTIGFIATRKFEVRHIRSHVEGVIVYIYSSPE...SGPDRNIVLVAP-r.........................
Q5JEN4_THEKO/2-163                  ...................................................................................EKLPKLYVETTQEEcvkdgkt.laecvvimGNVEVWLKENEEL...PD.F..IDP......S.RAKFLK...-REV........Y.DR-FYLYVD.RTEQKM.T.ADVILVLP....DGRTRIYLKKGD.ELMILPVEG.FTKTLIANVGNRVRTGDAFAAVTTRKGEVHYLKPPKTGTVVFIDEITN...--RPHYLYYILPE..........................
A0A117KPA8_9EURY/2-163              ...................................................................................EKIPLLFVESTAEEcveddka.kidciiiqKNIEVRLKKEEKL...PA.F..IDV......K.KAKFMK...-KEV........Y.DR-FRFYVD.KYEHRM.I.CDVIIVLP....DRRTEIRLYKGD.ELMLLPVEG.YVSSIIAEVGNRVRKSDAFAAITTKKGEVHYLKPPKNGTVIYIDEFTN...--RPHYVYYLLPE..........................
A0A256YG67_9CREN/4-156              ...................................................................................YAFPEVFVENIESD................---KYVLELDENTyvlVK.K..REN......Y.SYRRFF...GHII........Y.EH-ILEYIN.LTKPLI.E.RSFIVIKKy.tgGEMNGMLIEKNI.TPCLAEVSG.IYPYILVSEGEKISNKDKIAYIITNKGEIRTIKSPCDGFIALIINITW...EKPEKYILVVVKE..........................
A0A160VT47_9EURY/2-164              ..................................................................................a-RIPQLYVEATYDEcfdedgrakydciviqDNIELRLKKGEKL...PE.F..INK......D.RAKFLA...-KEV........Y.DR-FHFYVD.QYEHRM.K.VDAIIIYP....DRRTRIELKKGD.ELLLLPVEG.YVVTLIADVGNRVRTGDAFAAVTTKKGEIHYMKPPRPGTVVYIDEFTN...--RPNYVYYILPE..........................
C5A383_THEGJ/2-163                  ...................................................................................ERLPRLYVETSFEEcfageka.vedcvvimDNVEVWLGKGEAL...PG.F..IDV......E.RSKFLR...-REV........Y.DR-FYLYVD.RVESRM.L.ADAILVLP....DGRTRIYLRKGD.ELLLLPVEG.FTKTLIANVGNRVRTGDAFAAVTTRKGEVHYLKPPKSGTVVFIDEITN...--RPHYVYYILPE..........................
Y859_METJA/4-156                    ...................................................................................MRIPRLYVENAEKH................EGRKVVIENGGKV...IK.F..LDK......D.EEYEGD...GKVL........Y.QVIYDDFDNyVLMGTV.T.KDMIIEYEv..gGVRQITYIKKGT.KLLEIPAEG.YKVYPIVDFGCRILGGHRIAALQSRKGDIRFVNTPVNGIVLFLKEVPA...-KRENYVFYILPE..........................
R7PSJ1_9FIRM/21-94                  ......................................................................gesfafvpqmsvl--------------................-------------...--.-..---......-.------...----........-.---------.------.-.--------....------------.-------SG.KTVSVIA-EGTRVKEGDVLVLVDSLVGPVPAARATVDGVVIEVT----...-------------vgngqiidqndqvavi..........
O58980_PYRHO/20-181                 ..................................................................................g-RLPQLFVEVEREEclegdkv.kyeciiiqDNIEVKLKEGERV...PD.F..INI......E.RAKFLA...-KEI........Y.DR-FHFYVD.QYEHKM.R.VDAIIVYP....DRRTKMYLRKGD.ELMLLPVEG.YVVTLIADVGNRVRKGDPFAAITTRKGEVHYLKPPKPGTVVYIDEFTN...--RPHYVYYILPE..........................
I0A0D6_FERFK/6-145                  ................................................................................yrl--------EDDKKI................PSVKNYLKSNENI...ES.K..LDI......S.LDRIAC...EEII........F.NN--ISFGE.RNICVS.K.GNFIIKTP....KN--SFLIERNE.ELKYFIIEA.SQINTRKKPGDSVKKWDEIAVSKSKKGILRRIKIPFEGQIILVEQDPT...-YKPERIVFIL--k.........................
E0SQA2_IGNAA/15-153                 ..............................................................vsynsklyvdlekkifcdkpm--------------................-------------...--.-..---......A.DDNRVF...VEIV........Y.EKLPEIAID.FENNIL.R.IDVAIYIP....SKDIVLFIKRGS.NVDILEAQG.KIIIPLVNSGESVESNTKVFYRITKKYETRTHRAETVGLVVYIGEMFI...-------------gdsekmiavtvge.............
#=GC SS_cons                        ...................................................................................SE--EEEEET--SS................-S-EEEEEGGGTE...EE.E..E-T......T.----SS...SEEE........E.EESSS-GGGGEETTEE.S.S-EEEEET....TSSEEEEE-TT-.B-EEEEEES.SEEEESS-TSEEE-TT-EEEEEE-TTS-EEEEE-SSSEEEEEEEEETT...-CEEEEEEEEEE-..........................
#=GC seq_cons                       ....................................................................................+hPpLaVEs..p-...................clhlcps-pl....p.h..h-h......p.csphhh....K.l........Y.-p.h..alD.hhct+h.p.tchIlhhP....ct+stlhlc+Gs.cLhllPlEG.hpsslIsshGsRVccuDshAslsT+KGEV+al+sPhsGsVVaIcEhss.....pscYlhaIlPE..........................
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