GenomeNet

Database: Pfam
Entry: DUF2258
LinkDB: DUF2258
Original site: DUF2258 
#=GF ID   DUF2258
#=GF AC   PF10015.10
#=GF DE   Uncharacterized protein conserved in archaea (DUF2258)
#=GF AU   COGs;
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF AU   Eberhardt R;0000-0001-6152-1369
#=GF SE   COGs (COG4345)
#=GF GA   25.00 25.00;
#=GF TC   71.70 71.70;
#=GF NC   23.90 21.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   21348639
#=GF RT   Ab Initio Modeling Led Annotation Suggests Nucleic Acid Binding
#=GF RT   Function for Many DUFs.
#=GF RA   Rigden DJ;
#=GF RL   OMICS 2011;0:0-0.
#=GF DR   INTERPRO; IPR017140;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Members of this family of hypothetical bacterial archaeal have
#=GF CC   no known function.  Structural modelling suggests this domain
#=GF CC   may bind nucleic acids [1].
#=GF SQ   41
#=GS G7VE26_9CREN/37-108      AC G7VE26.1
#=GS A0A2U9IGZ2_9CREN/33-106  AC A0A2U9IGZ2.1
#=GS D5TZQ1_THEAM/14-91       AC D5TZQ1.1
#=GS D5U0V1_THEAM/5-81        AC D5U0V1.1
#=GS F9VNA1_SULTO/33-107      AC F9VNA1.1
#=GS D2RFH9_ARCPA/6-83        AC D2RFH9.1
#=GS H2C8Q8_9CREN/32-106      AC H2C8Q8.1
#=GS I3TE14_THEC1/12-89       AC I3TE14.1
#=GS B8D5F1_DESA1/9-86        AC B8D5F1.1
#=GS A0A2R4ZSL4_9CREN/4-81    AC A0A2R4ZSL4.1
#=GS H9ZZP1_FERFK/5-82        AC H9ZZP1.1
#=GS A2BM40_HYPBU/4-81        AC A2BM40.1
#=GS W7L5D2_9CREN/31-104      AC W7L5D2.1
#=GS G0EDV6_PYRF1/10-87       AC G0EDV6.1
#=GS Q4J9G8_SULAC/33-107      AC Q4J9G8.1
#=GS Q97Z40_SACS2/33-107      AC Q97Z40.1
#=GS L0ABD1_CALLD/5-82        AC L0ABD1.1
#=GS B6YVU6_THEON/3-74        AC B6YVU6.1
#=GS D3S1F3_FERPA/3-80        AC D3S1F3.1
#=GS Q9YAS7_AERPE/4-81        AC Q9YAS7.2
#=GS Q9YAS7_AERPE/4-81        DR PDB; 4PSN A; 4-81;
#=GS Q9YAS7_AERPE/4-81        DR PDB; 4PSO I; 4-81;
#=GS Q9YAS7_AERPE/4-81        DR PDB; 4PSO C; 4-81;
#=GS Q9YAS7_AERPE/4-81        DR PDB; 4PSN D; 4-81;
#=GS Q9YAS7_AERPE/4-81        DR PDB; 4PSO B; 4-81;
#=GS Q9YAS7_AERPE/4-81        DR PDB; 4PSO G; 4-81;
#=GS Q9YAS7_AERPE/4-81        DR PDB; 4PSO F; 4-81;
#=GS Q9YAS7_AERPE/4-81        DR PDB; 4PSN B; 4-81;
#=GS Q9YAS7_AERPE/4-81        DR PDB; 4PSO A; 4-81;
#=GS Q9YAS7_AERPE/4-81        DR PDB; 4PSO D; 4-81;
#=GS Q9YAS7_AERPE/4-81        DR PDB; 4PSN C; 4-81;
#=GS Q9YAS7_AERPE/4-81        DR PDB; 4PSO H; 4-81;
#=GS Q8U208_PYRFU/4-75        AC Q8U208.1
#=GS Q8U208_PYRFU/4-75        DR PDB; 4PSL D; 4-75;
#=GS Q8U208_PYRFU/4-75        DR PDB; 4PSM B; 4-75;
#=GS Q8U208_PYRFU/4-75        DR PDB; 4PSL C; 4-75;
#=GS Q8U208_PYRFU/4-75        DR PDB; 4PSM C; 4-75;
#=GS Q8U208_PYRFU/4-75        DR PDB; 4PSM D; 4-75;
#=GS Q8U208_PYRFU/4-75        DR PDB; 4PSM A; 4-75;
#=GS Q8U208_PYRFU/4-75        DR PDB; 4PSL B; 4-75;
#=GS Q8U208_PYRFU/4-75        DR PDB; 4PSL A; 4-75;
#=GS Q5JH67_THEKO/3-74        AC Q5JH67.1
#=GS F4B8U8_ACIHW/31-105      AC F4B8U8.1
#=GS C6A2Q2_THESM/4-75        AC C6A2Q2.1
#=GS W0I1T4_9EURY/4-75        AC W0I1T4.1
#=GS A0A075LSI7_9EURY/4-75    AC A0A075LSI7.1
#=GS A3DNP5_STAMF/12-89       AC A3DNP5.1
#=GS D9Q1S1_ACIS3/4-81        AC D9Q1S1.1
#=GS A4YFK6_METS5/33-106      AC A4YFK6.1
#=GS A0A2H5VET7_9ARCH/4-81    AC A0A2H5VET7.1
#=GS A1RRY4_PYRIL/37-108      AC A1RRY4.1
#=GS A0A2H5V4D3_9ARCH/4-81    AC A0A2H5V4D3.1
#=GS E0SQD7_IGNAA/4-81        AC E0SQD7.1
#=GS D9Q266_ACIS3/43-117      AC D9Q266.1
#=GS I3TG90_THEC1/4-86        AC I3TG90.1
#=GS Q8ZTN3_PYRAE/37-108      AC Q8ZTN3.1
#=GS G4RLL3_THETK/36-107      AC G4RLL3.1
#=GS A0A2J2H8F3_9CREN/36-107  AC A0A2J2H8F3.1
#=GS A3DL16_STAMF/4-81        AC A3DL16.1
#=GS A0A031LY15_9CREN/32-106  AC A0A031LY15.1
#=GS E1QUZ0_VULDI/36-109      AC E1QUZ0.1
G7VE26_9CREN/37-108                 IRTGVVVAARFADKLRRTAFAVFGGIVP.....-----REEIVRATSELNKKIYEALI-SMGVGKLDIVRITV..EAAVEGGR--li.
A0A2U9IGZ2_9CREN/33-106             ISTGLIIAARYADKLRRVSLVSLSKMVP.....-----KDIIIRDVSELNKKLYDEII-NRKIDKLSVIRITVtaHYDADKKKI-f..
D5TZQ1_THEAM/14-91                  LNTGIVIAGAYADKVRRTLFAQLKEVMK.....SNKDFTREVARASGELNRILYHILVETIRVEKGDAVRVRI..KYSVDSS---snr
D5U0V1_THEAM/5-81                   INTGLIPAAVYATKTRRALYALLQSLVK.....KDKEWDKIIKDEIGKLNRALYHLFTVDLKIDKTDVIRLRI..EFDVDEE---gr.
F9VNA1_SULTO/33-107                 LSTGLIIAARYADKLRRVALVAFSKMVP.....-----KDIIIRDISELNKQLYDVIVNQMKIDKLDVIRILVdaEYDEQNQKL-v..
D2RFH9_ARCPA/6-83                   LNTGLVIVGAYADKVRRTLFAQLKDKIK.....AKEIDSKMVAKAAGDLNKLLYEIFVNRLKLDKGDVVRIVV..DYDVRDGEV-v..
H2C8Q8_9CREN/32-106                 LSTGLIIAARYADKMRRIALVALGRLVP.....-----REVIVRDVAELNKQLYDILVNKMKVGKLDVVRIVVdaTYKEAEKR--lv.
I3TE14_THEC1/12-89                  LSTGLVIAGAYAQKVRRTLFAQLKDLTK.....NDKEMAKEAARATAELNRLLYYLIVDELKSDKGDAVRIRV..KYKVHPEK--kt.
B8D5F1_DESA1/9-86                   LNTGIVIAGAYADKLRRTLYAQLAGIVK.....TNKEFAREIARASAELNMLLFHVLVEGVKVDKGDAVRIRV..KYIIDEKAM-r..
A0A2R4ZSL4_9CREN/4-81               LSSGYVIAGGYADKLRRTAFAQLRDEIK.....GGVISSQEVARAVGELNSTLYKILVDRFKVDKGDVVRIRI..DYQIEGGKI-i..
H9ZZP1_FERFK/5-82                   LKTGPVRMSGYALKLRRATNAALRKLYQ.....EKKIEPKIANQMLTDLNKSLYDILINKYNIPKDAVINIEL..VLDISDSNL-n..
A2BM40_HYPBU/4-81                   LSTGLVIAGAYADKLRRVLFAQLRDEIK.....KGAIEPKQVAYRAGELNRLLFEILVNKLRIDKGDVVRIRI..EYELRDGDI-v..
W7L5D2_9CREN/31-104                 LSTGLIIAARYADKLRRVALVALSKIAP.....-----RDVIIRDISELNKKLFEEIT-QKNIGKLDVIRLVVvaEYDPQEKKI-k..
G0EDV6_PYRF1/10-87                  LSTGLVIAGAYADKLRRTLFAQLRDLLK.....QGKIEASEVARAAGEMNRLLYDIIVNKLKLDKGDVVRVRV..EYIVEEK---dgk
Q4J9G8_SULAC/33-107                 LSTGLIIAARYADKLRRVALVAFSRVAP.....-----KDVIVRDVAELNKKLYDIIVKEMKLNKLSVIRILVdaEYNERENKL-e..
Q97Z40_SACS2/33-107                 LSTGLIIAARYADKLRRVALVAFSKIAP.....-----KEVIIRDVSELNKQLYTKIVEEMKLGKLDVIRISVdaEYDDRNKKL-i..
L0ABD1_CALLD/5-82                   LKTGPVRMSGYALKLRRAANAAFRKLYA.....EKKVDPKVVNQLLTDLNKNLYGVLVENYNIPKDIIVNIQI..VFDLNDNSI-s..
B6YVU6_THEON/3-74                   LSTGFVRASGYAYKVRRVLFAITRGRVE.....-----PEEVVRAAAELNQYVFEKL-QEMGVNKGDVVRISV..PFSIEGGKI-k..
D3S1F3_FERPA/3-80                   LSSGLVIAGAYADKVRRTLFAQLRDMIK.....REEIESKEVARAAAELNRLLYELFVNKLKLDKGDVVRVRV..DYEVEEGVI-k..
Q9YAS7_AERPE/4-81                   LRTGLVIAAGYADKVRRVLFAQLRDAIK.....SGELSNKDVAMAAGNLNRVLFELLVNKLKADKLDVVRIQI..DYEVRDSQI-q..
#=GR Q9YAS7_AERPE/4-81        SS    EE--SEEGGGHHHHHHHHHHHHTHHHHH.....TTSS-HHHHHHHHHHHHHHHHHHHHTTS---TTSEEEEEE..EEEEESSEE-E..
Q8U208_PYRFU/4-75                   LMTGFVRASGYANKVRRVLFAITRGKVF.....-----PEEVVKAAGELNKIIFEKL-QEMGVKKEDVVRISV..DFNIEDGKI-v..
#=GR Q8U208_PYRFU/4-75        SS    EEEECEEGGGHHHHHHHHHHHHSTTTS-.....-----HHHHHHHHHHHHHHHHHHH-HHTT--TTSEEEEEE..EEEEETTEE-E..
Q5JH67_THEKO/3-74                   LNTGYVRASGYAHKVRRVLFALVKGKVD.....-----PKEVVRAAGELNSKIFEEF-QKLGVEKEDVVRISV..EFSIKDGSI-v..
F4B8U8_ACIHW/31-105                 LSTGLIIAARYADKLRRVALVSLSKMVP.....-----RDIIIRDVSEFNKNLYDKIVNQMKIDKLDVIKLVVsvRYDKSQNKL-i..
C6A2Q2_THESM/4-75                   LSTGFVRANGYANKVRKVLFALTRGKIV.....-----PENVVRASAQLNQYLFDKL-QELNVKKEDVVRISI..GFSIKSGEI-e..
W0I1T4_9EURY/4-75                   LLTGFVRAAGYANKVRKVLFAITRGKVN.....-----PEEVVRAAAELNQYLFSKF-QEIGVKKEDVVRIEV..EFEIKDGKI-e..
A0A075LSI7_9EURY/4-75               LLTGFVRASGYANKVRKVLFAITKGSVK.....-----PEEVVRAAGELNRYIFKKF-QELGVEKEDVIRIQA..PFEVKEG---lih
A3DNP5_STAMF/12-89                  LSTGLVIAGAYANKLRRTLFAQLKDLVK.....KNKEFAREVARASAEINRLLYIILVENLGCDKGDVVRVRV..KYVVDPSE--wr.
D9Q1S1_ACIS3/4-81                   LSTGLIIVGAYATKVRRALFALLSDRAK.....GDKEWSRRIAYSSAQLNRVLFELLVRKLKLDKGDVVRVRI..EFDVDENS--ke.
A4YFK6_METS5/33-106                 LSTGIIIAARFADKLRRVALVSLSRIVD.....-----REIIIRDISELNKELFNKLT-EMKIGKLDLVKIVVeaRYNREEKKL-h..
A0A2H5VET7_9ARCH/4-81               LSTGLVLVGAYSDKVRKTLFAQFSEEIK.....KNEINPQEIARASAELNRALYRLIVDELSSDKGDIVRIKV..DYSLEAGKI-i..
A1RRY4_PYRIL/37-108                 IRTGVVVAARFADKLRRTAFAVFGGVLP.....-----REEIVRATSELNKKIYEKLI-SMGVGKLDIVRITV..EAIIEGGKL-t..
A0A2H5V4D3_9ARCH/4-81               LQTGTVIVGYYATKIRRALFAQNRELLK.....TGQLEASEVARAAGELNQKLYTALVEKLVLSKGDIVRVEI..EYTVENSKI-i..
E0SQD7_IGNAA/4-81                   LSSGFVIAGAYADKIRRTMFAQLRDYVR.....RDKEWSQKIAFAVAQLNRFLYTVLVEQIKIDKGDVVRIRI..DYDIDEA---nkn
D9Q266_ACIS3/43-117                 ISTGVIIAARYADKLRRVALVALGKYIP.....-----KDVIIRDIAQLNKDLYHEIVEKRKLGKLDLVRITVtlHYDENEKRL-v..
I3TG90_THEC1/4-86                   VKTGPVRLSGYAIKLRKVVNASVSTALKnrpevSKKDVQKKVNEVLTNLNRVIYQVLVEKYMAPKDAIVNIEL..EYELVDTEF-k..
Q8ZTN3_PYRAE/37-108                 IRTGVVVAARFADKLRRTAFAVFGGVVP.....-----REEIVRATSELNKKIYEKLI-SMGVGKLDIVRISV..EASIEGGKL-a..
G4RLL3_THETK/36-107                 ISTGVIIAARFADKLRRAAFAAFKNMVK.....-----QEEILKSVADLNRSLYEKLV-AMGIGKLDIIRISV..EAKVEDGRL-t..
A0A2J2H8F3_9CREN/36-107             IRTGVIIAARYADKLRRAVFAAFRNAVK.....-----QEEVLRAVAELNRSIYDRLI-KMGVGKLDIIRITV..EARVDGGKL-t..
A3DL16_STAMF/4-81                   VRTGPVRVSGYALKLRRVVNAALRDYYK.....QKTLDAKEINNIISDLNAKIFNVLVERFEIPKDAIVNIIL..NYEVENNKF-v..
A0A031LY15_9CREN/32-106             ISSGLIIASRYADKLRRVALVTLGKMIP.....-----KDIIMRDIAELNKELYNKIVNELKVNKLDVIRLMVdvEYNPQEKKL-q..
E1QUZ0_VULDI/36-109                 LRTGIIIAARFADKLRRAAFAAFSKMVP.....-----EDVILRDIAELNKTVYDEMI-KRNIDKLALVRISVvvSYDQKANKL-n..
#=GC SS_cons                        EEEECEEGGGHHHHHHHHHHHHTCCCCH.....TTSS-HHHHHHHHHHHHHHHHHHHHCCTT--TTSEEEEEE..EEEEETTEE-E..
#=GC seq_cons                       LsTGlVIAutYADKlRRshFAthpchlp..........pcplsRssuELN+hLYchlVpchplsKhDVVRIpV..-Yslcsscl.h..
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