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Database: Pfam
Entry: DUF249
LinkDB: DUF249
Original site: DUF249 
#=GF ID   DUF249
#=GF AC   PF03158.14
#=GF DE   Multigene family 530 protein
#=GF AU   Mifsud W;0000-0002-9805-6461
#=GF SE   Pfam-B_2304 (release 6.5)
#=GF GA   27.40 27.40;
#=GF TC   27.80 32.20;
#=GF NC   27.30 27.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   11238833
#=GF RT   African swine fever virus multigene family 360 and 530 genes are
#=GF RT   novel macrophage host range determinants. 
#=GF RA   Zsak L, Lu Z, Burrage TG, Neilan JG, Kutish GF, Moore DM, Rock
#=GF RA   DL; 
#=GF RL   J Virol 2001;75:3066-3076.
#=GF DR   INTERPRO; IPR004858;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Members of this family are multigene family 530 proteins from
#=GF CC   African swine fever viruses. These proteins may be involved in
#=GF CC   promoting survival of infected macrophages [1].
#=GF SQ   19
#=GS 5051R_ASFP4/89-284   AC P0C9S5.1
#=GS 50510_ASFP4/87-279   AC P0C9V1.1
#=GS 5056R_ASFP4/87-284   AC P0C9U0.1
#=GS 5057R_ASFP4/87-284   AC P0C9U4.1
#=GS 5059R_ASFB7/87-276   AC Q89740.1
#=GS 5053R_ASFB7/89-277   AC Q89642.1
#=GS 5059R_ASFP4/87-276   AC P0C9U8.1
#=GS M1NLY6_9VIRU/82-219  AC M1NLY6.1
#=GS 5055R_ASFP4/87-276   AC P0C9T8.1
#=GS 5054R_ASFB7/87-280   AC Q89768.1
#=GS 5053R_ASFP4/89-277   AC P0C9T0.1
#=GS 50511_ASFP4/86-278   AC P0C9V4.1
#=GS 5052R_ASFB7/87-272   AC Q89702.1
#=GS 50511_ASFB7/86-278   AC Q65208.1
#=GS 50510_ASFB7/87-279   AC Q89869.1
#=GS 5057R_ASFB7/87-284   AC Q89925.1
#=GS 5054R_ASFP4/87-276   AC P0C9T4.1
#=GS 5052R_ASFP4/87-272   AC P0C9S8.1
#=GS 5055R_ASFB7/87-276   AC Q89777.1
5051R_ASFP4/89-284              .........GALEGNRHDL...IRKYDDQIKDHHEILPFIDNPVIFH.....KCHIMRR-CFFDCILYQAVKYSKFRVLLYFKYRL..ENDLPLAHLLVEKACEDHNYEVIKWL..YENLHIYNIMETFECAIAHKDLRLYRLGYTFIYNRIVPY.....KYHYLDVLILSglhLLYKVAAKGYLD.FILETLKYDHNNDNldIILTQAVTYNHRKILTYYIP-q..
50510_ASFP4/87-279              .........GALEGDRYDL...IHKYYDQIGDCHKILPLIQDPQIFE.....KCHELSNSCNIRCLLEHAVKHDMLSILQKHKEQI..RLHLALTQILFELACHERKNDIIRWI..GYSLHIHHLETIFDVAFAHKNLSLYVLGYELLMHKVNTE....aAYIELPNLLSY...HLRTAAAGGLLN.FMLETIKHGGYVDK..TVLSAAIRYKHRKIVAHFIHQ...
5056R_ASFP4/87-284              .........GALKTEKYSL...VCEYHSQIQDWHVLLPLIQDPETFE.....KCHDLSLECDFICLLQHAVKCDMLSILVKYKEDLlnVRIRHRIQSLFVLACENRRFEIIEWI..GQNLPIPEPEAIFSIAIVTKDIELFSLGYKLIFDYMQRQgtfqlTNMVRMLLLNR...YIGMAIEKGLLP.FIVETLKYGGSVN-..RALSYAVIDNKRKIIDYLVRH...
5057R_ASFP4/87-284              .........GALKTEKYSL...VCEYHSQIQDWHVLLPLIQDPETFE.....KCHDLSLECDLSCLLQHAVKYNMLSILVKYKEDLlnVLFRQQIQGLFILACENRMFEILTWM..GQNLPIPDPEPIFSIAVVTKDLEMFSLGYKIVFEYMENQglfhlTQVVRMVMLNR...HFSMVINKGLLP.FVLEILKHGGNVN-..RALSYAVTQNKRKILDHVVRQ...
5059R_ASFB7/87-276              .........GALEGRQYDL...IQKYYNQIGDCHENLPLIQDPEIYE.....RCHELNVTCTFQCLFQHAIRDNMLPIFQKYGEDL..NGNRRMVQLLYEMACRLQNYDIIKWI..GFNLHVYNLEAIFSIAFVRKDLTLYSLGYMLLLGRMSTE.....-DRNFISIITR...HLEYASKKGLFD.FVLESLKYGGQVD-..TVLFQAVKYNHRKILAHFIH-e..
5053R_ASFB7/89-277              .........GALESKYYDL...VYKYYDLVKDCHDILPLIQNPETFE.....KCHELNNPCSLKCLFKHAVIHDMLPILQKYTYFL..DGWEYCNQMLFELACSKKKYEMVVWI..EGVLGIGKVTSLFTIAISNRDLHLYSLGHLIILERMQS-.....CGQDPTFLLNH...FLRDVSIKGLLP.FVLKTIEYGGSKE-..IAITLAKKYQHKHILKYF---et.
5059R_ASFP4/87-276              .........GALEGRQYDL...IQKYYNQIGDCHQILPLIQDPEIYE.....RCHELNVTCTFQCLFQHAIRDNMLPIFQKYGEDL..NGNRGMVQLLYEMACRLQNYDIIKWI..GFNLHVYNLEAIFSIAFVRKDLTLYSLGYMLLLDRMST-.....VDRNFISIITR...HLEYASKKGLFD.FVLESLKYGGQVD-..TVLFQAVKYNHRKILAHFIH-e..
M1NLY6_9VIRU/82-219             cglikfmea----------...-------------------------.....--------------------------FRDLGYDI..KTKSTYLNAAFKIACKFRQIKMIKWL.iENDFDINFDPELFNVACYHDDTDVCKTLLELGFHVDITK.....--NETQELLIY...ILKNK-KMDLIDlFIKHNINF-NPLSS..YINNLPLDQNNEKIINVL---trn
5055R_ASFP4/87-276              .........GALEGDHYSL...IRKLYDQIKDCHNILPLIQDPKTFE.....KCHELDESCNISCLVLHAVKNDMLCILQEYKMRL..SGGD--IQEVFETACRSQKYDIVTWM..GENIAIYNPGVVFDIAFDLMNVSLLSIGYTLLFNHHINN.....MNENIDSLLAQ...HLEWAAGMGLLH.FMLETLKYGGDVTI..TVLSEAVKYDHRKVLDYFLR-r..
5054R_ASFB7/87-280              .........GALEGDHYDL...IHKYGSQIEDYHMILSSIHNANTFE.....KCHELSN-CDMWCLIQNAIKYNMLPILQKHRNIL..-THEGENQELFEMACEEQKYDIVLWI..GQTLMLNEPEFIFDIAFERIDFSLLTMGYSLLFNNKMSSid.ihDEEDLISLLTE...HLEKAATKGCFF.FMLETLKHGGNVNM..AVLSKAVEYNHRKILDYFIRQ...
5053R_ASFP4/89-277              .........GALESKYYDL...VHKYYGQVKDCHDILPLIQNPETFE.....KCHELNSTCSLKCLFKHAVMNDMLPILEKYTDYL..DRWEYCSQMLFELACRKKKYEMVVWI..EGVLCVGKVTSLFTIAISNRDLQLYSLGYSIILEKMYS-.....CRQDPTFLLNH...FLRDVSIKGLLP.FVLKTIEYGGSKE-..IAITLAKKYQHKHILKYF---et.
50511_ASFP4/86-278              .........QALKHNRKDVlecIFSYHLTTPKYHHIMHLTSSQELFEffhlfICKSKNYNARMECLLYAATLYNFPNILEKNREYI..-IRHSIGNSLFAIACKERHIHLIAWFvtAGVLDTYDDSTLFNTAFKLGDYSLLEVACDL--------.....PIIYPDYLIIS...MMQTAIQKNYFR.FFKKLLTHFNIYRQ..IIITDAAYYNRRKILLLLLNQ...
5052R_ASFB7/87-272              .........GALQGDQYDL...IHKYENQIGDFHFILPLIQDANTFE.....KCHALERFCGVSCLLKHATKYNMLPILQKYQEEL..SMRAYLHETLFELACLWQRYDVLKWI..EQTMHVYDLKIMFNIAISKRDLTMYSLGYIFLFDRGNTE.....-----ATLLTQ...HLEKTAAKGLLH.FVLETLKYGGNID-..TVLTQAVKYNHRKLLDYFLRQ...
50511_ASFB7/86-278              .........QALKHNRKDVlecIFSYHLTTPKYHHIMHLTSSQELFEffhlfICKSKNYNARMECLLYAATLYNFPNILEKNREYI..-IRHSIGNTLFAIACKERHIHLIAWFvtAGVLDTYDDSTLFNTAFRLGDYSLLEVACDL--------.....PIIYPDYLIIS...MMQTAIQKNYFR.FFKKLLTHFNIYRQ..IIITDAAYYNRRKILLLLLNQ...
50510_ASFB7/87-279              .........GALEGDRYDL...IHKYYEQIGDCHKILPLIQDPQIFE.....KCHELSNSCNIRCLLEHAVKHNMLSILQKHKDQI..RLHMALTQILFELACHERKNDIIRWI..GYSLHIYHLETIFDVAFAHKNLSLYVLGYELLMHKVNTE....aANIDLPNLLSY...HLRTAAAGGLLN.FMLETIKHGGCVDK..TVLSAAIRYKHRKIVAHFIHQ...
5057R_ASFB7/87-284              .........GALKTENYNL...VCEYHSQIQDWHILLPLIQDPETFE.....KCHDLSLGCDLICLLQHAVKCDMLSILVKYKEDLlnVRIRHRTQSLFVLACENRRFEIIEWI..GQNLSIPEPEAIFSIAIVTKDVELFSLGYKIIFDYMQRQgifqlTNVVRMLLLNR...HIGMAIEKGLLP.FILETLKYGGSVK-..RALSYAVIDNKRKIIDYLVRH...
5054R_ASFP4/87-276              .........GALEGNRYDL...IHKYGSQIKDYHMILSSIQNANTFE.....KCHELSN-CDMWCLIDNAIKYNMLSILQKHRNFL..-TEELENQEFFETACEEQKYDIVLWM..GQTLLLDEPKFIFDTAFKMVDFSLLTIGYSLLFDNKMD-.....IQDDLTSLLTE...HLEIAAAKGQLY.FMLETLKHGGDVNF..EVLSKAVENDHRKILDYFIR-rq.
5052R_ASFP4/87-272              .........GALQGDQYDL...IHKYENQIGDFHLILPLIQDAKTFE.....KCHALERFCGVSCLLEHATKYNMLPILQTYQEEL..SMRAYLRETLFELACLWQRYDVLKWI..EQTMHVYDLKIMFNIAISKRDLTMYSLGYILLFDRENTE.....-----ATLLTQ...HLEKTAAKGLLY.FVLETLKYGGNID-..IVLTQAVKYNHRKLLDYFLRQ...
5055R_ASFB7/87-276              .........GALESDHYSL...IRKLYDQIEDCHDILPLIQDPKIFE.....KCHELDKFCNILCLVLHAVKNDMLCILQEYKMHL..SGED--IQVVFETACRSQKNDIVSWM..GQNIAIYNSGVIFDIAFDKMNVSLLSIGYTLLFNHHINN.....TNENINSLLTQ...HLEWAAGMGLLH.FMLETLKYGGDVTI..IVLSEAVKYDHRKILDYFLR-r..
#=GC seq_cons                   .........GALcucpYDL...IpKYasQItDhH.ILPLIQsPchFE.....KCH-Ls..CshpCLlpHAlKhsMLsILpKa+-pL..ptpchhsQhLFElACcpp+a-llpWl..utsLplhcspslFsIAhsp+DloLaoLGYpLlhcph.sp.....st.shssLLsp...HLchAutKGLL..FhLETLKaGGslc...hlLotAVcYNHRKILsaFl+....
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