#=GF ID DUF3586
#=GF AC PF12131.12
#=GF DE Protein of unknown function (DUF3586)
#=GF AU Assefa S;0000-0003-2178-533X
#=GF SE PFAM-B_2164 (release 23.0)
#=GF GA 25.00 25.00;
#=GF TC 25.20 25.20;
#=GF NC 24.80 24.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF WK Domain_of_unknown_function
#=GF DR INTERPRO; IPR021981;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This domain is found in eukaryotes. This domain is about 80
#=GF CC amino acids in length and is found associated with Pfam:PF08246,
#=GF CC and Pfam:PF00112.
#=GF SQ 63
#=GS F9WG34_TRYCI/325-409 AC F9WG34.1
#=GS A0A3R7L7E7_TRYRA/431-508 AC A0A3R7L7E7.1
#=GS A0A061IW12_TRYRA/338-416 AC A0A061IW12.1
#=GS Q585E8_TRYB2/340-411 AC Q585E8.1
#=GS A0A0S4J628_BODSA/433-505 AC A0A0S4J628.1
#=GS A4H5E6_LEIBR/341-415 AC A4H5E6.1
#=GS A0A0S4ISD8_BODSA/417-492 AC A0A0S4ISD8.1
#=GS A0A061ISG7_TRYRA/314-392 AC A0A061ISG7.1
#=GS K2N0V2_TRYCR/163-244 AC K2N0V2.1
#=GS A0A061J2R5_TRYRA/72-150 AC A0A061J2R5.1
#=GS Q585E3_TRYB2/339-411 AC Q585E3.1
#=GS K2NGQ3_TRYCR/165-216 AC K2NGQ3.1
#=GS K2MUV8_TRYCR/97-176 AC K2MUV8.1
#=GS A0A061IVN7_TRYRA/338-416 AC A0A061IVN7.1
#=GS F9WI81_TRYCI/337-407 AC F9WI81.1
#=GS K2NFW0_TRYCR/165-212 AC K2NFW0.1
#=GS A0A3R7N6R7_9TRYP/553-630 AC A0A3R7N6R7.1
#=GS A0A3S5IRW0_TRYRA/118-195 AC A0A3S5IRW0.1
#=GS F9W8Z8_TRYCI/417-486 AC F9W8Z8.1
#=GS F9W525_TRYCI/340-409 AC F9W525.1
#=GS A0A6L0WJ22_LEIIN/341-417 AC A0A6L0WJ22.1
#=GS F9W406_TRYCI/338-409 AC F9W406.1
#=GS A0A7G2CCS2_9TRYP/14-90 AC A0A7G2CCS2.1
#=GS F9WBU6_TRYCI/335-407 AC F9WBU6.1
#=GS Q585E5_TRYB2/340-412 AC Q585E5.1
#=GS K2NJB9_TRYCR/165-244 AC K2NJB9.1
#=GS F9WHV8_TRYCI/334-407 AC F9WHV8.1
#=GS K2MZ62_TRYCR/149-214 AC K2MZ62.1
#=GS A0A0S4JAK7_BODSA/419-491 AC A0A0S4JAK7.1
#=GS A0A0S4II93_BODSA/467-544 AC A0A0S4II93.1
#=GS A0A061JAN4_TRYRA/338-416 AC A0A061JAN4.1
#=GS Q4E0J7_TRYCC/338-417 AC Q4E0J7.1
#=GS F9WCM4_TRYCI/112-182 AC F9WCM4.1
#=GS Q4CMU6_TRYCC/338-417 AC Q4CMU6.1
#=GS A0A0S4J628_BODSA/328-401 AC A0A0S4J628.1
#=GS Q4QI66_LEIMA/341-417 AC Q4QI66.1
#=GS A4H5E4_LEIBR/341-415 AC A4H5E4.1
#=GS A0A0S4J9Z8_BODSA/404-477 AC A0A0S4J9Z8.1
#=GS F9W3K5_TRYCI/336-380 AC F9W3K5.1
#=GS K2MZR4_TRYCR/166-238 AC K2MZR4.1
#=GS F9WRA9_TRYVY/338-416 AC F9WRA9.1
#=GS F9WDX9_TRYCI/335-407 AC F9WDX9.1
#=GS A4H5E5_LEIBR/341-415 AC A4H5E5.1
#=GS Q4QI61_LEIMA/341-417 AC Q4QI61.1
#=GS K2N1N4_TRYCR/172-251 AC K2N1N4.1
#=GS Q585F0_TRYB2/340-412 AC Q585F0.1
#=GS A0A0S4JW93_BODSA/421-493 AC A0A0S4JW93.1
#=GS A4HA92_LEIBR/343-418 AC A4HA92.1
#=GS F9W388_TRYCI/334-407 AC F9W388.1
#=GS Q4DW02_TRYCC/338-417 AC Q4DW02.1
#=GS A0A061ITN9_TRYRA/165-243 AC A0A061ITN9.1
#=GS A0A0S4KNQ2_BODSA/18-80 AC A0A0S4KNQ2.1
#=GS A0A0M9FRR5_LEPPY/339-414 AC A0A0M9FRR5.1
#=GS A0A0N0DRL4_LEPPY/336-410 AC A0A0N0DRL4.1
#=GS K2MNE5_TRYCR/73-151 AC K2MNE5.1
#=GS S9VFY9_9TRYP/338-415 AC S9VFY9.1
#=GS F9WTE7_TRYVY/169-247 AC F9WTE7.1
#=GS Q585E2_TRYB2/340-411 AC Q585E2.1
#=GS A0A0M9G5S5_LEPPY/343-423 AC A0A0M9G5S5.1
#=GS F9WG06_TRYCI/338-407 AC F9WG06.1
#=GS Q4CTX9_TRYCC/52-131 AC Q4CTX9.1
#=GS S9TX36_9TRYP/338-415 AC S9TX36.1
#=GS Q4DW03_TRYCC/338-417 AC Q4DW03.1
F9WG34_TRYCI/325-409 tnqclmkeyarsavvsgpvp-----PP----....--PPP....ASTFTQEFCQDA.ECQSGCTKATFPTGKCVQL.SGAGSVIASCGSN..NLTQIVYpLSSSCSG-y....
A0A3R7L7E7_TRYRA/431-508 ...................g-PAPTPDPSTTt..tTSAPG....PSLLVQQLCWGP.ECATGCVNMSFPTGRCVQT.SSGVSAILTCDAT..SVVEKLFpLSSDCTG-l....
A0A061IW12_TRYRA/338-416 ...................g-PAPTPNPSTTt.ttTSAPG....PSLLVQQLCSGP.GCTTGCVNSSFPTGQCVQA.FGRVSAILTCDAT..SAVEKLFpLSTDCTGP.....
Q585E8_TRYB2/340-411 ..................gg-PTPPPPP---....--PPP....SATFTQDFCEGK.GCTKGCSHATFPTGECVQT.TGVGSVIATCGAS..NLTQIIYpLSRSCSGP.....
A0A0S4J628_BODSA/433-505 .................pap---PTPPPTT-....-AAPA....GGTFVQMQCSDA.ACSVGCSNYTFNLNVCIPL.GGGGSAIATCNSQ..GLLLNEY.STSTCTG-s....
A4H5E6_LEIBR/341-415 ....................SGSTTPGPTTT....TKAPK....GLVVVQTTCTDY.FCRKGCKEEVFKTSKCYKS.TGGKSVTMQCGMS..EVLVRTY.PSSDCSGT.....
A0A0S4ISD8_BODSA/417-492 .................spp---ATPTPNTPp..tPPTPS....GKTFTQYVCQDF.FCTSGCQGNTFNQDVCLQT.ENGGSAIVTCGS-..ELKIKSY.TSTDCSG-s....
A0A061ISG7_TRYRA/314-392 ...................g-PAPTPNPSTTt.ttTSAPG....PSLLVQQLCSGP.GCTTGCVNSSFPTGQCVQA.FGRVSAILTCDAT..SAVEKLFpLSTDCTGP.....
K2N0V2_TRYCR/163-244 ..................vg--SPGPTPRANhhdnHKCPRt..vPIHFVQMSCTDA.ACSVGCENATFPTGQCLLT.TSGGSAIATCNAE..TLTEEVFfTSTHCSGP.....
A0A061J2R5_TRYRA/72-150 ...................g-PAPTPNPSTTt.ttTSAPG....PSLLVQQLCSGP.GCTTGCVNSSFPTGQCVQA.FGRVSAILTCDAT..SAVEKLFpLSTDCTGP.....
Q585E3_TRYB2/339-411 .................vgg-PTPPPPP---....--PPP....SATFTQDFCEGK.GCTKGCSHATFPTGECVQT.TGVGSVIATCGAS..NLTQIIYpLSRSCSG-l....
K2NGQ3_TRYCR/165-216 ..................sp--GPTPEPTTTt..tTSAPGp..sPSYFVQMSCTDA.ACSVGCENATFPTGQ----.-------------..-------.--------sspdh
K2MUV8_TRYCR/97-176 .................rsr---PTPEPTTTt..tTSAPGp..sPSYFVQMSCTDA.ACSVGCENATFPTGQCLLT.TSSGSAIVTCGTE..TLTEEVFfTSTHCSGP.....
A0A061IVN7_TRYRA/338-416 ...................g-PAPTPNPSTTt.ttTSAPG....PSLLVQQLCSGP.GCTTGCVNSSFPTGQCVQA.FGRVSAILTCDAT..SAVEKLFpLSTDCTGP.....
F9WI81_TRYCI/337-407 ..............avvsgp-----PPP---....---PP....TPTFTQELCEGA.ECQSKCTKATFPTGKCVQL.SGAGSVIASCGSN..NLTQIVYpLSSSCSG-f....
K2NFW0_TRYCR/165-212 ..................sp--GPTPEPTTTt..tTSAPGp..sPSYFVQMSCTDA.ACSVGCENVTFPT------.-------------..-------.--------vsv..
A0A3R7N6R7_9TRYP/553-630 ...................g-PAPTPDPNTTt..tTRPPG....PPFFVQQLCSDR.VCAEGCQNVTFPTNRCLQT.TDGGSAVLTCDTA..YVNEEVFpLSQSCTGP.....
A0A3S5IRW0_TRYRA/118-195 ...................g-PAPTPDPSTTt..tTSAPG....PSLLVQQLCWGP.ECATGCVNMSFPTGRCVQT.SSGVSAILTCDAT..SVVEKLFpLSSDCTG-l....
F9W8Z8_TRYCI/417-486 ...............vvsgp-----PPP---....---PP....ASTFTQEFCEGA.ECQSGCTKATFPTGKCVQL.SGAGSVIASCGSN..NLTQIVYpLSSSCSG-f....
F9W525_TRYCI/340-409 ...............hrpvp-----PPP---....---PP....ASTFTQEFCEGA.ECQSGCTKATFPTGKCVQL.SGAGSVIASCGSN..NLTQIVYpLSSSCSG-f....
A0A6L0WJ22_LEIIN/341-417 ....................PRSLTPGPGTEs..eERAPK....RVTVEQMMCTDM.YCREGCKKSLLTANVCYKN.GGGGSSMTKCGPQ..KVLMCSY.SNPHCFGP.....
F9W406_TRYCI/338-409 ...............vvsgp-----PPP---....-PPPP....ASTFTQEFCEGA.ECQSGCTKATFPTGKCVQF.GGAGSVIASCGSN..NLTQIVYpLSSSCSG-f....
A0A7G2CCS2_9TRYP/14-90 ...................g-PTSSRAPTSSt..sTHAPT...pSTVFTQKNCWDS.SCNVWCEDTSYPTDTCIHV.DDR-HAILTCTND..EIIQTVY.DDATCSGK.....
F9WBU6_TRYCI/335-407 .............rsavvsg----PPPP---....---PP....ASTFTQEFCEGA.ECQSGCTKATFPTGKCVQF.GGAGSVIASCGSN..NLTQIVYpLSSSCSG-f....
Q585E5_TRYB2/340-412 ..................gg-PTPPPPP---....-PPPP....SATFTQDFCEGK.GCTKGCSHATFPTGECVQT.TGVGSVIATCGAS..NLTQIIYpLSRSCSGP.....
K2NJB9_TRYCR/165-244 .................rsr---PTPEPTTTt..tTSAPGp..sPSYFVQMSCTDA.ACSVGWENATFPTGQCLLT.TSGGSAIVTCGAE..TLTEEVFfTSTHCSGP.....
F9WHV8_TRYCI/334-407 ...........arsavvsgp-----PPP---....---PP....TPTFTQELCEGA.ECQSKCTKATFPTGKCVQL.SGAGSVIASCGSN..NLTQIVYpLSSSCSG-f....
K2MZ62_TRYCR/149-214 ..................sp--GPTPEPTTTt..tTSAPGp..sPSYFVQMSCTDA.ACSVGCENATFPTGQCLLT.TSGGSAIVTCNAE..T------.--------l....
A0A0S4JAK7_BODSA/419-491 ................dasg------PPQ--....TPAPT...wNGPVSQVQCSDD.NCSVNCTTVTFAQDVCTGL.NGGGSAIGQCKAG..MLEQYVFpLSNNCTG-l....
A0A0S4II93_BODSA/467-544 ................rynp-----NGPVM-....TPAPA...yLGNYTQRACNQSsPCTEGCVSTSLPQNVCLQM.DGGGSFMSRCDMQgqVLVQSAYiLSTTCEGP.....
A0A061JAN4_TRYRA/338-416 ...................g-PAPTPNPSTTt.ttTSAPG....PSLLVQQLCSGP.GCTTGCVNSSFPTGQCVQA.FGRVSAILTCDAT..SAVEKLFpLSTDCTGP.....
Q4E0J7_TRYCC/338-417 ..................gp--GPTPEPTTTt..tTSAPGp..sPSYFVQMSCTDA.ACIVGCENVTLPTGQCLLT.TSGVSAIVTCGAE..TLTEEVFfTSTHCSGP.....
F9WCM4_TRYCI/112-182 ..............vsgpvp-----PPP---....---PP....ASTFTQEFCEGA.ECQSGCTKATFPTGKCVQL.SGAGSVIASCGSN..NLTQIVYpLSSSCSG-y....
Q4CMU6_TRYCC/338-417 .................gpg---ATPEPTTTt..tTSAPGp..sPSYFVQMSCTDD.ACIVGCENVTLPTGQCLLT.TSGASAIVTCGAE..TLTEEVFlTSTHCSGP.....
A0A0S4J628_BODSA/328-401 ..................ka--SPTPAPGPT...pAPAPS....DAWFTQRTCSND.KCTN-CTNDVLPQNSCI-T.GSGSSFKATCATD..GLIVSSY.SSSDCSG-s....
Q4QI66_LEIMA/341-417 ....................SQSPTPGPNTTt..tTHAPK....RVTVKQITCTDY.FCRKGCKTTVIPTKECLPN.GAGGSFQMECGDH..QVLKLTY.TSMNCTGE.....
A4H5E4_LEIBR/341-415 ....................SGSTTPGPTTT....TKAPK....GLVVVQTTCTDY.FCRKGCKEEVFKTSKCYKS.TGGKSVTMQCGMS..EVLVRTY.PSSDCSGT.....
A0A0S4J9Z8_BODSA/404-477 ...............ydpvg------PP--Q....TPAPT...wNGPISQVQCSDD.NCSVNCTTITFAQDVCLTL.NGGGSAISQCNSG..MLEQWMFpFANNCTG-l....
F9W3K5_TRYCI/336-380 ..............savvsg----PPPP---....---PP....TPTFTQELCEGA.ECQSKCTKATFPTGQCVQL.S------------..-------.--------g....
K2MZR4_TRYCR/166-238 .................rsr---PTPEPTTTt..tTSAPGp..sPSYFVQMSCTDA.ACSVGCENATFPTGQCLLT.TSGGSAIATCGAE..TLTEEVF.--------ft...
F9WRA9_TRYVY/338-416 ...................t-PTPTPTPTTTt..tTTAPG...pSSSFTKTLCSGD.DCADNCSATVYNTNTCIRL.GALGSMVATCGAG..VLELKAYmQNEQCTGT.....
F9WDX9_TRYCI/335-407 ..........ssalvngppp-----------....--PPP....PPIFTQEFCQTP.KCLGECTKAAFRTGKCIQM.SRAGSVIASCGSN..NLTQIVYpLSSSCSG-y....
A4H5E5_LEIBR/341-415 ....................SGSTTPGPTTT....TKAPK....GLVVVQTTCTDY.FCRKGCKEEVFKTSKCYKS.TGGKSVTMQCGMS..EVLVRIY.PSSDCSGT.....
Q4QI61_LEIMA/341-417 ....................SQSPTPGPNTTt..tTHAPK....RVTVKQITCTDY.FCRKGCKTTVIPTKECLPN.GAGGSFQMECGDH..QVLKLTY.TSMNCTGE.....
K2N1N4_TRYCR/172-251 .................rsr---PTPEPTTTt..tTSAPGp..sPSYFVQMSCTDA.ACSVGCENATFPTGQCLLT.TSGGSAIVTCGAE..TLTEEVFfTSTHCSGP.....
Q585F0_TRYB2/340-412 ..................gg-PTPPPPP---....-PPPP....SATFTQDFCEGK.GCTKGCSHATFPTGECVQT.TGVGSVIATCGAS..NLTQIIYpLSRSCSGP.....
A0A0S4JW93_BODSA/421-493 .........qeqsssilkya-----------....---PQp..yMGYFAQKQCISS.TCNVLCEEAYFPQSLCMLA.Q-NGSMTATCTAD..GLLVKSY.VTTSCVG-a....
A4HA92_LEIBR/343-418 ....................GTTTSRAPTT-....TEAPKp..sETVLVQKKCLLN.GCSRLCTSTTYPTGVCLRR.RGGGSVMVTCQEE..EVVELIF.RSSSCSGN.....
F9W388_TRYCI/334-407 ...........arsavvsgp-----PPP---....---PP....TPTFTQELCEGA.ECQSKCTKATFPTGKCVQL.SGAGSVIASCGSN..NLTQIVYpLSSSCSG-f....
Q4DW02_TRYCC/338-417 ..................gp--GPTPEPTTTt..tTSAPGp..sPSYFVQMSCTDA.ACIVGCENVTLPTGQCLLT.TSGVSAIVTCGAE..TLTEEVFlTSTHCSGP.....
A0A061ITN9_TRYRA/165-243 ...................g-PAPTPNPSTTt.ttTSAPG....PSLLVQQLCSGP.GCTTGCVNSSFPTGQCVQA.FGRVSAILTCDAT..SAVEKLFpLSTDCTGP.....
A0A0S4KNQ2_BODSA/18-80 .............svhgrky-----------....-----....---FYQNVCSDS.SCRDNCQESELPQNECLIT.TGGGSAVCHCTES..AFEQDVYvFTDNCT--l....
A0A0M9FRR5_LEPPY/339-414 .................vsg---KTHAPVTT...sTVAPG....ATVVEQTTCRDH.MCTLSCRTARVPVDECRKD.SDSGSFKVQCGLD..QVIERRY.ASNDCSG-v....
A0A0N0DRL4_LEPPY/336-410 .............satvsgn------ATTTT....TKAPQ....PMVVEYTACQDR.HCHKNCTTKRLPVGECLKG.HN-TSSILLCGRD..QVVEASY.ASSDCSG-l....
K2MNE5_TRYCR/73-151 .................srh----TPEPTTTt..tTSAPGp..sPSYFVQMSCTDA.ACSVGCENATFPTGQCLLT.TSGGSAIVTCGAE..TLTEEVFlTSTHCSGP.....
S9VFY9_9TRYP/338-415 ................eggp-----APPSTT....TKAPTsppsGEVFVQKNCLDS.GCSYLCRETTYATDTCLPT.KDAASVVVHCNST..HVVEETF.QAADCTGE.....
F9WTE7_TRYVY/169-247 ...................t-PTPTPTPTTTt..kTTAPG...pSSSFTKTLCSGD.DCADNCSATVYNTNTCIRL.GALGSMVATCGAG..VLELKAYmQNEQCTGT.....
Q585E2_TRYB2/340-411 ..................gg-PTPPPPP---....--PPP....SATFTQDFCEGK.GCTKGCSHATFPTGECVQT.TGVGSVIATCGAS..NLTQIIYpLSRSCSGP.....
A0A0M9G5S5_LEPPY/343-423 ...................g-PTTPRPPIAS...aAPAPAqatnGKVIIQRKCHNS.GCTLLCSNVTFPTGVCVPSkKNGGSAILSCSGT..EVSEQVF.TSNDCSGT.....
F9WG06_TRYCI/338-407 .............vvggppp-------P---....---PP....ASTFTQEFCEGA.ECQSGCTKATFPTGKCVQL.SGAGSVIASCGSN..NLTQIVYpLSSSCSG-y....
Q4CTX9_TRYCC/52-131 .................gpg---ATPEPTTTt..tTSAPGp..sPSYFVQMSCTDA.ACSVGCENVTLPTGQCLLT.TSGASAIVTCGAE..TLTEEVFfTSTHCSGP.....
S9TX36_9TRYP/338-415 ................eggp-----APPSTT....TKAPTsppsGEVFVQKNCLDS.GCSYLCRETTYATDTCLPT.KDAASVVVHCNST..HVVEETF.QAADCTGE.....
Q4DW03_TRYCC/338-417 ..................gp--GPTPEPTTTt..tTSAPGp..sPSYFVQMSCTDA.ACIVGCENVTLPTGQCLLT.TSGVSAIVTCGAE..TLTEEVFlTSTHCSGP.....
#=GC seq_cons ..................ss...ssPsPsos....T.APs....suhFsQphCpss.sCssGCpssTFPTGpClps.suuGSsIsoCuus..slsptla.hSosCoG......
//
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