#=GF ID   DUF3785
#=GF AC   PF12653.8
#=GF DE   Protein of unknown function (DUF3785)
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Jackhmmer:Q181X2
#=GF GA   27.00 27.00;
#=GF TC   28.30 54.70;
#=GF NC   24.40 22.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR024210;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This family of proteins is functionally uncharacterised.This
#=GF CC   family of proteins is found in bacteria. Proteins in this family
#=GF CC   are approximately 140 amino acids in length. These proteins
#=GF CC   share two CXXC motifs suggesting these are zinc binding
#=GF CC   proteins. This protein is found in clostridia in an operon with
#=GF CC   three signalling proteins, suggesting this protein may be a
#=GF CC   DNA-binding transcription regulator downstream of an as yet
#=GF CC   unknown signalling pathway (Bateman A pers obs).
#=GF SQ   50
#=GS A0A1M5TFL0_9CLOT/2-135  AC A0A1M5TFL0.1
#=GS A0A1I0W758_9CLOT/3-138  AC A0A1I0W758.1
#=GS A0A2A7MLZ1_9CLOT/3-135  AC A0A2A7MLZ1.1
#=GS A0A084J947_9CLOT/4-137  AC A0A084J947.1
#=GS A0A371IVI0_9FIRM/4-139  AC A0A371IVI0.1
#=GS A0A1H0U545_9CLOT/3-138  AC A0A1H0U545.1
#=GS A0A1M6F4Z5_9CLOT/4-139  AC A0A1M6F4Z5.1
#=GS A0A174W8V6_9CLOT/1-127  AC A0A174W8V6.1
#=GS A0A2S6FWT5_9CLOT/4-139  AC A0A2S6FWT5.1
#=GS A0A1M6KY26_9CLOT/4-139  AC A0A1M6KY26.1
#=GS A0A0B3VX37_9FIRM/2-138  AC A0A0B3VX37.1
#=GS G7MAR6_9CLOT/3-136      AC G7MAR6.1
#=GS V9HFA0_9CLOT/3-138      AC V9HFA0.1
#=GS K6TT62_9CLOT/3-136      AC K6TT62.1
#=GS U5MXI4_CLOSA/3-136      AC U5MXI4.1
#=GS A0A1E5L8Q6_9BACL/4-138  AC A0A1E5L8Q6.1
#=GS A0A1M4NE89_9CLOT/4-138  AC A0A1M4NE89.1
#=GS A0A2T0BCA4_9CLOT/1-135  AC A0A2T0BCA4.1
#=GS A0A0C1RB24_9CLOT/3-135  AC A0A0C1RB24.1
#=GS A0A3P7PTZ5_9FIRM/4-138  AC A0A3P7PTZ5.1
#=GS A0A173WU47_CLOVE/3-139  AC A0A173WU47.1
#=GS A0A0A1S3S7_PAESO/4-139  AC A0A0A1S3S7.1
#=GS A0A1M5MTW8_9FIRM/4-139  AC A0A1M5MTW8.1
#=GS A0A1G9P4I7_9FIRM/4-139  AC A0A1G9P4I7.1
#=GS L1Q454_9CLOT/7-142      AC L1Q454.1
#=GS C4ICU6_CLOBU/3-136      AC C4ICU6.1
#=GS U2Q069_9CLOT/2-137      AC U2Q069.1
#=GS Q8XK35_CLOPE/2-134      AC Q8XK35.1
#=GS Q181X2_PEPD6/4-139      AC Q181X2.1
#=GS R5XF76_9CLOT/2-137      AC R5XF76.1
#=GS T0PAC7_9CLOT/4-136      AC T0PAC7.1
#=GS A0A343JCD9_9CLOT/3-138  AC A0A343JCD9.1
#=GS N9WHK4_9CLOT/3-137      AC N9WHK4.1
#=GS B6FWA5_9FIRM/3-138      AC B6FWA5.1
#=GS A0A1I7J6A0_9CLOT/1-135  AC A0A1I7J6A0.1
#=GS M1MN48_9CLOT/3-136      AC M1MN48.1
#=GS A0A1M4Z187_9CLOT/4-136  AC A0A1M4Z187.1
#=GS R6KLV4_9CLOT/3-138      AC R6KLV4.1
#=GS A0A1I1SAG3_9CLOT/3-139  AC A0A1I1SAG3.1
#=GS A0A1D7XN12_9CLOT/3-139  AC A0A1D7XN12.1
#=GS A0A1V4J185_9CLOT/3-136  AC A0A1V4J185.1
#=GS A0A174HGY5_9CLOT/3-138  AC A0A174HGY5.1
#=GS A0A1E5G2Z5_9BACL/2-137  AC A0A1E5G2Z5.1
#=GS A0A1S8TQT7_9CLOT/3-136  AC A0A1S8TQT7.1
#=GS A0A371IYX4_9FIRM/4-139  AC A0A371IYX4.1
#=GS T0CMU0_PAESO/1-38       AC T0CMU0.1
#=GS A0A0A7FUK8_9CLOT/3-138  AC A0A0A7FUK8.1
#=GS A0A2P2BPC5_9FIRM/4-139  AC A0A2P2BPC5.1
#=GS A0A1M6ICG5_9CLOT/2-137  AC A0A1M6ICG5.1
#=GS A0A1V1HZF9_9FIRM/4-139  AC A0A1V1HZF9.1
A0A1M5TFL0_9CLOT/2-135             ..YKFNYNDKEYELKKEKCQDFFNDEE...K...PVIGFEVEEVLEVLKS.G.E..NVKFDLEYYKEACEACYDGQ--RQKSYKFLEYFFYVFTKDANYVTSSISNEYKDTSYNKLLKEKKVDNSYIVKVIVCENCGEFTVEVEECEI...
A0A1I0W758_9CLOT/3-138             ..YKFIFKDKEYDLIEEKCECFFNDEE...T...PINNIEVLNILDLLNK.A.E..NINFGLEYYAEPCEVCLHGKEQRKKVFPFLEYHFYIFTKDNNYITSSISNDYEENSYSGIYKKGKVDNSYIVSIMICENCGDYIIEIEQCN-m..
A0A2A7MLZ1_9CLOT/3-135             ..YTFTFKDKEYVLSKENCEGIFFND-...D...EIENFNLELILDILIN.S.D..EVDFSKEYYTGQC-TC-KKQEPLNKAYCYLEYHFYIYTKDDKYIISTISSDYENTSFNKLFSTGKIDNSYIVSIAVCPECGTYSIEVNQCEV...
A0A084J947_9CLOT/4-137             ..FKFKHKDEEFILSEDNLSYIEAEE-...-...-VQDFTIGKVLEILEE.GkE..KVEFDYEYYADNCEACGNSEAIDKKHYRYLEYHFYIFTKEGKYIISNISNEFETTTYSQLERMKKIDESYIVSIIICESCKNFAIEVEQCD-m..
A0A371IVI0_9FIRM/4-139             ..YKFSYDEKEYTLEEVNCSSLINDEE...K...PVKDINVSSIMEILNE.S.E..DIDFDIEYYQEACPECLAGVKEKEKFFPFLEYHFYIFTKDGKYIISNISKEYEGLSFNKLSRQGKVDDSYIVSIIICKNCQDYIIQIENCIV...
A0A1H0U545_9CLOT/3-138             ..YKFTFEEKEYDLNEEKLVGFFNDEE...N...EILGIDENKILDMLNN.S.T..EVDFEKTYYKEVCENCLAGKAEKKKVFDYLEYYFYVYSKNGTYVSSNISNEYDGLSFTRLERQKTVDTSYIVTINVCAHCGDFTIEIEKF--el.
A0A1M6F4Z5_9CLOT/4-139             ..YQFVFNDKNYELTLENLEAVINDEE...S...PVQGINASNILELLNE.N.S..EVSFDAEYYEESCENCKTGVAEKAKYFEFLEFHFYIFTKDSNYVMSTLSKAYEDTSYNRLLKQGKVDKSYIASVIVCKHCSDYSIEIEQCEI...
A0A174W8V6_9CLOT/1-127             mv----------TLENERLEGFFNDEN...N...PIKDINEETIINMIKD.R.-..NVDFEKAYYSLTCESCGGEKVENERAYKFLEYHFYIYTKDGKYVTNSLAVEEEGKSFNRLQREGLVDNSYIVSIIVCAGCGAFNIEIEEFE-i..
A0A2S6FWT5_9CLOT/4-139             ..YTFNFNGKTYELSLDKFDYLLNDEE...N...EVTGIDIEDILTLLNE.S.P..EVDFDLEYYSVPCEICLAGKEEKKRYFNFLEYHFTIFTKENEYVMSNISKEFEDTSFTELQALGKIDNSFIVIIMVCESCGTYSIEINQCD-i..
A0A1M6KY26_9CLOT/4-139             ..YQFTYDEKTYILSQENCSGLINDET...D...PVKGIGIKEILDLLKG.Q.E..EVDFDIAYYGEPCSNCLAGKAEKLKYFPFLEYHFYLFTKAGEYVTSSISKDYEGTSFDKLLKEKKVDNSYIANIILCTNCGDYTIEIEQCEV...
A0A0B3VX37_9FIRM/2-138             ..FKFTFDEKEYILNDENFDELINDDE...K...PVKNIDRDMIIELLNN.SpE..EIIFDEEFYIEACPKCLKGIKEKEKFFPFLEYHFYIYTKDGKYVISTIDKDYKGKSFNKLSRANLVDDSYIVSTIICKHCNDYIIQIENCEV...
G7MAR6_9CLOT/3-136                 ..YKFSHNGKEYVLTKENCDGIFFDDE...A...TVSGLSMDIILDALNE.G.E..EVNFSNEYYMGKC-SC-NSQEEVNKSYRYLEYHFFIYTKNNQYVINTIGNEYKHTSFNQLFGFGKVDDSYIVSVTVCPNCGEYSISVEQCTV...
V9HFA0_9CLOT/3-138                 ..YKFKFDEKEYILGEDNLEYFANDEN...E...ELEGIDGEKILELLSN.S.D..EVEFQNAYYESCCSNCKAGKEEKKKVFDFLEFYFYAYGKNNKFITSSIDNEYDKKSFTRLNRERIVDKSYLVTVIVCKNCGTYSIEIEEF--el.
K6TT62_9CLOT/3-136                 ..YKFTHDNKEYILTKENCDGIFFEDE...N...EVTGLSIDMILDALNE.G.D..EVSFSNEYYADKC-SC-NTQEQINKSYRYFEYHFYSYTKNNEYIINTISNEYKNTSFNKLFGLGKIDDSYIVSVTVCPNCGIYSVYVDQCTV...
U5MXI4_CLOSA/3-136                 ..YTFIHENKEYVLSNDNCEGLFFEDE...N...EITGLSFDIILEALNN.S.N..DVNFSNEYYVGKC-QC-GEQEKINKSYRYLEYHFYIYTKNNTYVINTISKEYENTSFNKLFNLGKVDDSYIINVTVCPICGLYAIEVSQCTV...
A0A1E5L8Q6_9BACL/4-138             ..YTFSYDGKELVLHEGNCIEFYNDEE...Q...PVEGLSLPQILQLLKE.Y.P..DVTFDLEYYNGACPSCLAGKEEKAKVFKFLAYNFSVYTLERQYVISSISKD-KDATFSQMLKHGKVDNSYSVSVVVCPSCGDYSIEILECEV...
A0A1M4NE89_9CLOT/4-138             ..FKFTYMDKAYELGENNLEYFLNDEE...K...PVRGIDRESIIKLLLE.G.E..EVSFSKEYYDEPCGNCLNGKVYGQKYFKFLEYHFFIYTKDGNYVISNISKDRKD-NFSTLLNRGLVDDSYIVSLMVCDNCGNYAIEIEQCEI...
A0A2T0BCA4_9CLOT/1-135             .m-KFTVNKEEYVLDEDKFGAFRNDEE...K...PVQNIDEEDILKILEN.R.-..ELDFEKAYYSIPCENCNSEKSGEKKIYKFFEYHLYLYTKDCEVVTNSLDIKDEETSFKRLLNQKEVDNSYIVTIMVCCDCGDFEIEIDEFE-i..
A0A0C1RB24_9CLOT/3-135             ..YKFNFENREYELKEDNLEYIYDEN-...-...-IEGFEYETLIELLNN.S.D..KVSFDLEYFDGRCDVCEAGKGEGRKHYDFLEYHFFVFTKNNKYIISTISKDYEEGIYTDLYKRKVIDNDFIVSIIVCKECGAWMVEIEQCD-m..
A0A3P7PTZ5_9FIRM/4-138             ..YEWMYKDKKIILDSEKCSIFLNDED...N...PLSGITVEEILELLHE.S.D..LVDFSMEYYDQGCEACHNNKSDKSNSDRFLEFHFYLFAKAGKYVMSSLSKAYEEKTLPRLLNEGIVDGTYIVSINVCQVCGDYTIELE----ygl
A0A173WU47_CLOVE/3-139             ..YKFIFKGKEYELNEEKAIGFFNDEE...K...PIKDMDIKKIINIFEN.S.DedEVDFDKEYYDVRCEKC-KVNKEDKDYYEYLEFNFYMFTKDSKYIISNISKEYEGVTFNKLLREGIVDDSYIVTIIVCKNCGVYSVVIEEFE-i..
A0A0A1S3S7_PAESO/4-139             ..YKFKFKDKEYELNKSNCSGVINDED...K...PVTNIDLDEVLRLLNE.T.Q..DVDFDLEYYQEACPECLSGVKEKQKFFGFLEYHFYLFTKNGEYVISDISKDYEGLSFNKLSRAGKVDDSYIVSIIMCESCSDYIVQIENCIV...
A0A1M5MTW8_9FIRM/4-139             ..YKFNYNGKEYILSQESCSGLVNDDE...K...PVKGIEISDVIDLLNS.S.D..KVDFDIEYYQEACPECLAGVKEKQKFFGFLEYHFYIFTKNGEYVISDISSDYQGLSFNKLSRQNKVDDSYIVSIIVCESCQDYTVQIENCIV...
A0A1G9P4I7_9FIRM/4-139             ..YKFNYEEKEYILSQKNCSDIINDEE...K...PVKGTSLDKILNILNE.S.D..DIDFDIEYYQEACPECLAGVKEKQKFFGFLEYHFYIFTKNGEYVISDIDNDYQGLSFNKLSRSGKVDDSYIVSIIVCENCQDYIVQIENCIV...
L1Q454_9CLOT/7-142                 .n-KFSFDGKEYCLNEEKLDYFVNDEI...N...PIEDIDEKKVIEILNN.S.D..NVEFTKAFFDLPCDVCKEGVSEKKKFFDFLGFNFYIYTKNNQYVVSTLDKEYEGMSYNRLQRSGKINGSYIVLINVCRNCGSYSIEIEEFEV...
C4ICU6_CLOBU/3-136                 ..YKFTYNSKEYTLSSKNCEGIFFENY...E...EIKGLSLETILEALNS.N.E..EVSFSKEYYAGKC-TC-DLQEKIEKYYCYLEYHFYIYTKEQEYVINTICKEYEDTSFNKLFRAGKIDKSHIVNITVCPECGTYSIEIEDCEV...
U2Q069_9CLOT/2-137                 ..YTLKFNEKTYELTENNCEDFIMDEE...Y...KIEGVSVKNILNLLNE.A.E..NISFDREYYSEYCSSCKEEDIVKSKFYEYLGYSFYIFTKDSKYVESNISESYKDSSFGRLFRSNVVDNSFIVNIIFCEKCNKYTIEIEQCD-m..
Q8XK35_CLOPE/2-134                 ..FSFTFDEKEYTLSEDKLLYFFNED-...-...-VEGFDIDKLFEILNS.S.E..GVSFGKAYYDGPCEECKFGLEEKKKSFPFLEFNMFIYAKNGKFVISNIEKAYEGLTYNKLLRDKKVDKSYLVNINVCKNCGNFAVEVEELEV...
Q181X2_PEPD6/4-139                 ..YKFIYDDKEYLLKEENCSALINDEE...N...PVQGVSISKIIDILNE.A.E..EVDFDVEYYQEACPLCLEGVKEKKKFFPFLEYHFYIFSKDGEYVISNISVDYKGLSFNKLSRANKVDNSYIVSVIICENCQDYIVQIENCIV...
R5XF76_9CLOT/2-137                 ..LKFVYDEKEYVLEKDKNVCFLNDEE...K...PVEGISLDDILNMIDN.L.E..EIDFDTQYYKEACVECLDGVKEKQKFFAFLEYHFYIYTKDQKFIISDIQKEYEGQSFNKLLRANKVDDSYIVSLIICKNCGDTLIQIENCVV...
T0PAC7_9CLOT/4-136                 ..YKFQYEDKEFELKEDNCDYINNEE-...-...-VENFNISTVLDLLNK.G.E..EVGFTVEYYDSCCEECKFNRKDDTKFFEFLEYHFYIFTKENNYVLSTISPEYQEVTLTSLVRDKKIDNSHIVSILVCKNCGTWAIEVEQCD-m..
A0A343JCD9_9CLOT/3-138             ..YKFIFEGKEYILGEENLEYFANDEN...K...PLEGIDYKKVLEILNK.S.D..EVDFQKAYYENCCSKCRWGKEEKKKVFDFLEFYFYVYGKNNKYITSSIDGEYDKKSFTRLNREGIVDKSYLLTIIVCRKCGTYSIEIEEFEV...
N9WHK4_9CLOT/3-137                 ..YKFNFEKKEYILNEESLLELINDEE...S...PVEGFDLNEVLRLLNE.G.N..-LEFDKAYYSSSCDSCDSNFKEKRNVSEYVEGFFYIYTKNKKYVIANIDKDYEGKTYHKLELLGEVDDSYIVSIIICKNCGKFIIQIEELVV...
B6FWA5_9FIRM/3-138                 ..YKFNCDGREYVLDSEKCSEFFNDEE...K...EVSGFSVEEAMRLVSE.A.E..DVEFAKEYYQEACPDCMAGVKEKQKFFAFYEYHFYIFTKDGKYVISDIDKEYKGNSFNKLSRAGEVDDSYIVSIIVCAECGEYIVQVENCEV...
A0A1I7J6A0_9CLOT/1-135             .m-KVCVDNKEYLLDKEHFGGFLNDEE...N...PINNIDEEFILNILEK.-.R..NLDFEKAYYSAPCTKCESGGKNKLRAYPFYEYHFYLYTKDRNVVWNSFKVEEEGYSFTRMEREGKADDSYIVSVIICAECGDYEIEVEQFEV...
M1MN48_9CLOT/3-136                 ..YKFAYDNKDYLLTNENCEGLFFEDD...N...EIVGLSLDLILNALNE.G.E..DVAFSNEYYSGKC-SC-NTQDEVNKSYRYLEYHFYIYTKNKEYVINTIENEYKATSFNKLFNAGKIDDSYIVIVTACPNCGVYSISVEQCTV...
A0A1M4Z187_9CLOT/4-136             ..YEFSLNNNTFKLEESNCFDFFNED-...-...-VNGVNLTNILDILSEnT.P..TLEFQKEYYSSPCDNCKNGKG-EEKVFDFLEGHFFIFTKNNEYIMSDISKEYENTSFRRLLAEGKVDDSYIVEISICPYCKNYSIEIDQCP-i..
R6KLV4_9CLOT/3-138                 ..YRFTFEGREYKLNKENLDYFINDEE...N...PIKNIDLDKVLEIMTN.S.N..EVDFSKEYFDMPCGECKDGLREKKKFFAFLGYNFYIYTKNGEFVISSIDKEYEGLSFNRLQKAGKVDNSYIVLVNVCKHCGSYSVEIEEFE-i..
A0A1I1SAG3_9CLOT/3-139             ..YKFIYDNKDYVLSEENCDGIFYESEeenD...DVKDVSLDMILTALSQ.G.E..NINFTKEYYCDKC-LC-DNQEQLNKSYCYLEYHFYIYTKEKHYIINTICEEYKDTSYNKLFRAGKIDDSYIVSIIVCPHCSTYSVEIEQCTV...
A0A1D7XN12_9CLOT/3-139             ..YKFLYDNKEYQLNKENCEGIFLNSD...NdieEIENLSVELILSSLCE.G.N..EVNFSKEYYGDKC-LC-DIQEELNKSYAYLEYHFFIYTKENKYIINTICKDYESTSYNKLHRSGKIDNSYIVSIIVCPCCGNYTIEIEQCTV...
A0A1V4J185_9CLOT/3-136             ..YKFTYDNKEYILTQNNCDGIFFADE...S...EVNGLSVDMVLNALNE.G.E..EVSFSNEYYADKC-SC-DAQEQINKSYRYLEYHYYIYTKDNEYIINTISNEYKNTSFNKLFGLGKIDDSYIVSVTVCPSCGNYSINVEQCTV...
A0A174HGY5_9CLOT/3-138             ..YTCKFDEKEYILNEENLYCFFNDEE...N...PINDVDEKKIIEILNN.S.D..KVDFSKAYFNLACENCQTGVEEKKKFFDFLGYNFYIFTKNGKYVVSNIEPQYEGSTYDKLYALGKVDNSYLVTINVCKHCGEYSIEIEEF--el.
A0A1E5G2Z5_9BACL/2-137             ..YTLSYEDKKFELNEQNLAEFNNDDE...K...PVSGIEPIDIIKLLSE.Q.A..NLDFEIEYFNRACQVCFAGKEEKAKYFTFLVYSFYLYTKDGTYVMSNLSKEYEGKSFSKLLNAGIVDDSYCVSVLVCDSCGKYTIEILQCD-i..
A0A1S8TQT7_9CLOT/3-136             ..YKFISDGKEYILTEENCEGIFFDDE...N...EVIGLSVNTVLTALNE.G.E..EVNFSNEYYSGKC-SC-DTQEQINKSYRYLEYHFYIYTKNNEYVINTISEEYKITSFNRLFSLGKIDDSYIVNVTVCPNCGTYSIDVEQCTV...
A0A371IYX4_9FIRM/4-139             ..YKFNYEEQEYLLSEKNCTALINDEE...K...PVKGISVNDIINMINN.A.S..DIDFDVEYYQEACPDCLAGVKEKEKFFPFLEYHFYIFTKDGKYVISDISKEYEGLSFNKLSRQNKVDDSYIVSIIACKSCQSYIIQIENCTV...
T0CMU0_PAESO/1-38                  .m-------------------------...-...----------------.-.-..-------------------------------------------------------SFNKLSRAGKVDDSYIVSIIMCESCSDYIVQIENCIV...
A0A0A7FUK8_9CLOT/3-138             ..YIFKYEDKEIKLSKDNLIEVINDEE...M...PIEDINIETIIKLLNE.G.E..DVKFEKAYYSTPCEKCDSNFKEKRNISEYLEYYFYVYTKDNKFVISDISKEYENLTYNRLELEGKVDNSYIVTVIVCANCNEYLVQIEEIEV...
A0A2P2BPC5_9FIRM/4-139             ..YKFNYEDKEYVLSLDNCSGLLNDEE...K...PVDGIKLENILEMLSN.G.S..EIDFDMEYYQEACPECLKGVKEKQKFFGFLEYHFYIFTKNGKFVISDIDKSYEGLSFNKLLRAGKVDDSYIVSIIICENCQDYIIQIENCIV...
A0A1M6ICG5_9CLOT/2-137             ..YKFNFNEKEYELNDEKCVAFFNDEE...R...KVKEVNLNKILEILNK.A.E..NIEFSREYYGSYCEECLNGKEEKAKEFSFLEYHFYIFTKNDTYIVSSISPEYESNTYGNLVKIRKVDNSYIVSIIVCEKCGAFTVEIEQCE-m..
A0A1V1HZF9_9FIRM/4-139             ..YKFNYEDTEYVLSANNCSELINDEE...K...PVKGITVDSILNMLNE.A.D..DVDFDIEYYQEACPECLAGVKEKQKFFGFLEYHFYILTKNGEYVISDISKEYKGLSFNKLSRQGKVDDSYIVSIIICEKCQDYIIQIENCVI...
#=GC seq_cons                      ..YKFsa-sKEYhLsc-NspshhNDEE...p...sVpGlslcpILclLsp.u.-..-VcFspEYYspsC.pChsGpcE+pKhasFLEYHFYIaTKsscYVISsIup-Y-spSFN+L.+tGKVDcSYIVSIlVCcsCGsYsIEIEpCpl...
//