#=GF ID   DUF3804
#=GF AC   PF12707.8
#=GF DE   Protein of unknown function (DUF3804)
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   jcsg_3hzp
#=GF GA   22.50 22.50;
#=GF TC   22.60 22.80;
#=GF NC   22.30 22.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR024525;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family is approximately 130 residues.  Dali search
#=GF CC   indicates this protein carries a NTF2-fold with a hydrophobic
#=GF CC   cavity as a structural homologue to 1JB2, 2R4I, 3FSD and 2UX0. 
#=GF CC   In this hydrophobic cavity, Arg 118 provides the H-bonding force
#=GF CC   to hold a PEG molecule from crystallisation. The interface
#=GF CC   interaction suggests that the biomolecule of Swiss:Q46KI2 is a
#=GF CC   dimer. Two members of the family are annotated as putative EF-Tu
#=GF CC   domain 2 but there is no match to this family so this is likely
#=GF CC   to be a false assignment. There are two highly conserved
#=GF CC   tryptophan residues towards the C-terminal end of the family.
#=GF SQ   11
#=GS Q46H33_PROMT/23-149      AC Q46H33.1
#=GS A0A1Y1IDG9_KLENI/76-189  AC A0A1Y1IDG9.1
#=GS V4XX68_9PROT/5-131       AC V4XX68.1
#=GS A7MDJ2_PROMT/1-30        AC A7MDJ2.1
#=GS Q46KI2_PROMT/2-129       AC Q46KI2.1
#=GS Q46KI2_PROMT/2-129       DR PDB; 3HZP A; 2-128;
#=GS R1EHD2_EMIHU/1-95        AC R1EHD2.1
#=GS Q46KN8_PROMT/1-47        AC Q46KN8.1
#=GS C1FHB7_MICCC/1-82        AC C1FHB7.1
#=GS A9BC66_PROM4/14-140      AC A9BC66.1
#=GS A3PEN9_PROM0/2-72        AC A3PEN9.1
#=GS K8F230_9CHLO/3-127       AC K8F230.1
Q46H33_PROMT/23-149                 ...........................SDSQQLEALIQSFADRSQNK..TFLLANTTNDFLAIRPSCNPIIAKGLAGMYDS.DDLVIELSELV..KIHRL..E-.A.DSDWGFTAFTLKEVFSYKGDLNND.LSIYSL.IF.KK.I.DGIWKIVWMQRSQGTTDISTWD.....
A0A1Y1IDG9_KLENI/76-189             ....ayiqngisnvwytssedaiipgg--------------------..-----------MFIRASGNPLKMEGLAAFVEE.NDELFEE-KVL..DIEKL..E-.I.RGDVAWTVLKMYQDFSYRGTRHKD.TFRYTV.ILeRK.P.LERWRVAHMHRSS---------plke.
V4XX68_9PROT/5-131                  .........................in--EDDIQALIKNFSSVGKNV..DVVKTRTTPDFRFIRPSGNPLDAAGFAHMFAS.GELVMQSIGLS..KVHRL..D-.V.YGERAFAAFTQVATFTYKGEPNDD.VFTVTA.LF.EK.I.DGLWYFSWMQRSSGQADSAAW-f....
A7MDJ2_PROMT/1-30                   ...........................--------------------..-----------MAIRPSGNPITAEGLAGMYDS.ADLVIELSE--..-----..--.-.------------------------.------.--.--.-.----------------------.....
Q46KI2_PROMT/2-129                  ...........................SSKEEILSILEAFASTERMG..SFFLDNATADFLFIRPSGNPLDAKGFENMWSS.GDLVLESAEIT..KVHKF..EL.L.GSNAAICVFTLGSKFTYKGTQNDD.LPTVTS.IF.KK.I.DEKWKVAWMQRSSGQSDMTLWN.....
#=GR Q46KI2_PROMT/2-129       SS    ...........................-HHHHHHHHHHHHSSTTTTT..THHHHHB-TT--EE-TTS-EE-HHHHHHHHTS.SSEEEEEEEEE..EEEEE..EE.S.SSSEEEEEEEEEEEEEETTEEEEE.B-EEEE.EE.EE.E.TTEEEEEEEEE--SB--GGG-X.....
R1EHD2_EMIHU/1-95                   .........................ad--------------------..--------DDVQMIRPSGNPLSKAEWATMFAS.EDVVIESDELV..SIDSV..RIfA.GGNAAVATYSKHSKFIYKGDENDD.YAVFSA.TL.EK.K.GGDWKVVFVMRATG--------.....
Q46KN8_PROMT/1-47                   ...........................--------------------..--------------------------------.-----------..-----..--.-.----------MKEEFNYKGERNND.LSSYSL.IF.KK.I.DGTWKISWMQRSQGTTDLSTW-s....
C1FHB7_MICCC/1-82                   .........................mm--------------------..--------------------------KAMMDS.KDVTGVSGDLI..DIKML..DF.SeDRTMAYSAVVASATFSYKGTPNDD.VYVFTN.VF.KK.V.DGVWETVWGHRSTGRS------pde..
A9BC66_PROM4/14-140                 ...........................SDSQSIEALIKGFANRSENK..SFLISNVTENFLAIRPSGNPITAEDLVGMYNN.ADLVVEVSELV..KIHRL..E-.A.NADWGFAAFTLKEQFSYKGENNND.LSSYSM.IF.QK.R.DGAWKISWMQRSSGTTDLSTWN.....
A3PEN9_PROM0/2-72                   .......................slli---------------QKKMA..SFFVDNATPDFLFIRPSGNPIDAKGFEKMITC.-DIVQEKAEIT..KIHRF..EF.L.NENIVMCIFTLG------------.------.--.--.-.----------------------.....
K8F230_9CHLO/3-127                  .......................teet----QLRELIKDQLTTA-NK..EEFLAKMPQNAWFIRPSGNPASKEIMVEMMSS.GDITEAKTELV..EIKHV..E-.V.MQDCAYAVLIAKSSFDYKQTKNED.VYTQSC.FF.KK.TsDGKFELAWGHRSTGR-------gfeed
#=GC SS_cons                        ...........................-HHHHHHHHHHHHSSTTTTT..THHHHHB-TT--EE-TTS-EE-HHHHHHHHTS.SSEEEEEEEEE..EEEEE..EE.S.SSSEEEEEEEEEEEEEETTEEEEE.B-EEEE.EE.EE.E.TTEEEEEEEEE--SB--GGG-X.....
#=GC seq_cons                       ..........................................................shhhIRPSGNPlstcshssMhsS.sDlVhEpsEls..cI++l..-..h.ttshuhsshshtppFsYKGp.NsD.l.shoh.lF.cK.h.DGhWclsWhpRSoGp............
//