GenomeNet

Database: Pfam
Entry: DUF4354
LinkDB: DUF4354
Original site: DUF4354 
#=GF ID   DUF4354
#=GF AC   PF14263.6
#=GF DE   Domain of unknown function (DUF4354)
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   JCSG:Target416839_SP17692A
#=GF GA   25.00 25.00;
#=GF TC   25.30 25.50;
#=GF NC   24.90 24.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR025581;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Several members of this family are annotated as being
#=GF CC   ATP/GTP-binding site motif A (P-loop) proteins, but this could
#=GF CC   not be confirmed. The one PDB:3NRF structure solved for this
#=GF CC   family exhibits an immunoglobin-like beta-sandwich fold. 
#=GF CC   Crystal packing suggests that a tetramer is a significant
#=GF CC   oligomerisation state, and a disulfide bridge is formed between
#=GF CC   Cys 125 at the C-terminal end of the monomer, and Cys 69.
#=GF SQ   26
#=GS L0MGL6_9GAMM/1-123      AC L0MGL6.1
#=GS L0EUW8_LIBCB/1-121      AC L0EUW8.1
#=GS B2VCP2_ERWT9/1-118      AC B2VCP2.1
#=GS A0A2A2HQF3_9GAMM/1-123  AC A0A2A2HQF3.1
#=GS D3V905_XENNA/1-123      AC D3V905.1
#=GS W7BIQ0_9LIST/3-108      AC W7BIQ0.1
#=GS A0A2A2GVA1_9GAMM/1-65   AC A0A2A2GVA1.1
#=GS Q2YR31_BRUA2/1-111      AC Q2YR31.1
#=GS H7F7P5_9LIST/29-140     AC H7F7P5.1
#=GS Q11IS2_CHESB/1-120      AC Q11IS2.1
#=GS Q9I2H0_PSEAE/1-123      AC Q9I2H0.1
#=GS Q9I2H0_PSEAE/1-123      DR PDB; 3NRF B; 23-123;
#=GS Q9I2H0_PSEAE/1-123      DR PDB; 3NRF A; 25-123;
#=GS Q9I2H0_PSEAE/1-123      DR PDB; 3SB3 A; 25-123;
#=GS A0A0F5FHI2_9RHIZ/1-119  AC A0A0F5FHI2.1
#=GS A0A0Q4MHG1_9GAMM/1-123  AC A0A0Q4MHG1.1
#=GS A0A1Y3FXR1_9PROT/1-124  AC A0A1Y3FXR1.1
#=GS G9Z9K9_9ENTR/1-123      AC G9Z9K9.1
#=GS C4K5R4_HAMD5/1-123      AC C4K5R4.1
#=GS A0A0F0A0W5_9FLAO/1-23   AC A0A0F0A0W5.1
#=GS Q2NPZ4_SODGM/1-56       AC Q2NPZ4.1
#=GS I0QRX2_9GAMM/1-123      AC I0QRX2.1
#=GS G9Z376_9ENTR/1-123      AC G9Z376.1
#=GS A0A176V1A3_9PSED/1-123  AC A0A176V1A3.1
#=GS A0A0N1KIM1_9GAMM/1-126  AC A0A0N1KIM1.1
#=GS S3J1Z3_9ENTR/1-123      AC S3J1Z3.1
#=GS W1JCY7_9GAMM/1-123      AC W1JCY7.1
#=GS A0A0J9BH82_9BACT/1-122  AC A0A0J9BH82.1
#=GS D8MW40_ERWBE/1-120      AC D8MW40.1
L0MGL6_9GAMM/1-123                 .............................MKIsTMAASLALAGCCFAA.N---AATPKNIAVYATEKSTGSISIGGKDA.YTKTFDVALAKLPGDDIDLS..K..LCLKAYSPDNQAFKLDTV.....DETLTSGSLKEGKLVKGIAVFAADSAAVYSAALVKITD...........
L0EUW8_LIBCB/1-121                 .............................MKK.---SYLLLYPICFLF.SIAASSVPPEVIVYAKQKETGSIFSPHKFT.YTKDFDVTVVNFSQGEIDLS..K..YCFKAM-LGMKEFNVDTI.....DEKLASKKLKNGERLRGVVVFSSNNSDVTQANIVQLTD...........
B2VCP2_ERWT9/1-118                 ............................m---.--AASVTVAGFCSVA.H---AAVPDNAAVYATEHSKGSMSIAGKDV.YTKTFEVMVANLADKEFDLS..T..LCLKAVAPDHQEFKLDTV.....DEKLTTGKVKKGQSVKGIAVFASDNAAVQQTALVKLTD...........
A0A2A2HQF3_9GAMM/1-123             .............................MKGkILLTALAFSSVSMIA.S---AVETDNLVVYSTQQDKGATSLGNQAF.YTKSFDVTLANVGDKDADLS..K..FCLKAYNKHGKTFKLDTI.....EETLTTGNLLPKKTVKGMAVFASNDESVYDASIVKLS-y..........
D3V905_XENNA/1-123                 .............................MKVsTFVASIALAGFCFVA.N---ASTLDRVAVYSTEKSNGSVSVGGKNA.YTKSFEVAVANLSDKDIDLS..K..LCLKAYSPDKKEFRLDTV.....DEDLNQGTLKAGKSVRGIAVLASENDVVHKAALIKIS-a..........
W7BIQ0_9LIST/3-108                 .........................knla---.---------------.--NKSQVVDGLKITIKKQEENEKVEGKKKE.NLYTFTIEGENASSVKKGLG..S..IDFVLKTKDKKEVKLDD-.....SLATFGNELKSGEKLSGKVSFATNK-------------apdklvykpng
A0A2A2GVA1_9GAMM/1-65              ............................m---.---------------.------------------------------.-------------DQPIELT..GdvACYKAFDEKGKEFDGRLV.....QAEL--LGILKDSPKAGEATFVSDDESVYNAKFVKWS-s..........
Q2YR31_BRUA2/1-111                 .........................maqa---.---------------.SYAETASTNDLMIIATPKTQSATSSEDKVF.FSQTFDIGVANTGATDINLD..K..VCFIALGDKGKTFNADTI.....DQKLTSGLLKSGESVKGFAAFAGSDKSIYDVRIVKAS-e..........
H7F7P5_9LIST/29-140                ...................tdtkatetak---.---------------.AETKDTVVDGLKIKVKKQEVDEKVSDKKKQ.QLYTFTISGENMSSTNKGLG..A..VDFVLKTKDGKEIEVDP-.....SMAMFGDEIKPGKTLEGKASFAVDEKQ-----------tatklly....
Q11IS2_CHESB/1-120                 .............................MKN.TYAYSILAMAFVLLS.CSEKAIVEGPIKVTSTRDALEVETDEPGDQ.--KAFKVKVENIGVAPVDLT..D..GCFVLVGPDKYKIVANT-.....--PVLDRTILPGQILEGSVVFAGPR-SIFSAREVKFS-ts.........
Q9I2H0_PSEAE/1-123                 .............................MKN.--AMALTLAGLLAAP.SLGFAAAPDAVMVFARQGDKGSVSVGDKHF.RTQAFKVRLVNAAKSEISLK..N..SCLVAQSAAGQSFRLDTV.....DEELTADTLKPGASVEGDAIFASEDDAVYGASLVRLSD...........
#=GR Q9I2H0_PSEAE/1-123      SS    .............................XXX.--XXXXXXXXXXXXX.XXXXXXXXSSEEEEEEEEEEEEEEETTEEE.EEEEEEEEEEE-SSS-EE-T..T..-EEEEEETTS-EEEEEEE.....-GGGG-SEE-TT-EEEEEEEEEESSSGGGGEEEEEEES...........
A0A0F5FHI2_9RHIZ/1-119             ...........................ma---.------ALAAFTTLA.VATPALANDDIAIIATERANGSMALGDTIA.YSKSFDIALTNTVDEPVALE..D..LCLVAVTAEGDTFVLDTV.....DESLTTGMIEPGAALNGIAVFSSDSITVHTASAVRA--gsd........
A0A0Q4MHG1_9GAMM/1-123             .............................MKS.LFIACTMLFSAACGA.A--VANAPANLLVYAQAKSEGSMWAGSKSA.FTKTFNVSIVNLTDQDIDLA..T..LCLRAYATDTQSFGVDTA.....DELLTKGWLKKGSTVSGVVDFSSGKRDVYQAGMVKV--fh.........
A0A1Y3FXR1_9PROT/1-124             ..........................mkf---.--SAYIIAASLLLGSvTSAYANAYDSISVYAIEKSHGSIATGSNTA.YVKTYNITISNLSDTEADLS..K..ICLKAYSAENKELRLDTV.....DANLVTGFLKKGQPATGTAIFASHDDIISKPVIVKLSD...........
G9Z9K9_9ENTR/1-123                 .............................MKLsTVVASAVLAGFSFAA.N---ASAIDNVAVYATEKANGSMFVAGKSA.FTKTFDVTIANLSSEEVDLS..R..LCLKAYTADNKAFKLDTV.....DETLTEGKLKEGKPVKGIAVFASEKEDVMKAGLIKLT-a..........
C4K5R4_HAMD5/1-123                 .............................MRKkIFIASILLAGCCLTA.A---AKTVDKIIVFSTEKSKGALSIGRQQT.YTKTFDIALSNNSQQDIELS..T..SCLKAFDSNGKEFKLDTV.....DEKLIPNKLKKGELVKGIAMFVSDDASVYGANIVRLVK...........
A0A0F0A0W5_9FLAO/1-23              .......................mvqqvt---.---------------.------------------------------.--QGIKISV-----------..-..------------------.....--------------------------------------ktefdgtfyk.
Q2NPZ4_SODGM/1-56                  .............................---.---------------.------------------------------.--------------------..-..MCLKAYNGHGKSFKLDTI.....DDTLTTEKLAPKKTLKGIAVFSSNDESVYDASMVKLSD...........
I0QRX2_9GAMM/1-123                 .............................MKVyTIVLSLALSSICVGA.N---ATTLDNIGVYSTQESQGSVSIGSKNA.YTKTFEVVLANLSGESVDIS..K..LCLKAYSKDNKEFNLDTV.....DEKLTSGMLKYGKPVKGNAVFSSDNDEVLNAALVKISD...........
G9Z376_9ENTR/1-123                 .............................MKFsHIAASVILSGFCFSA.Y---ASPTDNIAVYSTEKSNGSISIGGQSV.FTKTFEVELAKLSGDTVDLS..K..LCLKAYSAKNKEYKLDTI.....DEEIATGMLKYGRPTKGIAVFASEDSEILQATLVKIS-a..........
A0A176V1A3_9PSED/1-123             ........................mkfss---.----IIAPITLSLIA.LTAHAKGLDHVIVVSTQKSSGTMSVGDKSA.YTQSFDIFLGNLKGREIDLA..G..YCLKAYGIEGQEYKLDTV.....DEALTVGKLKVGAPVQGMAMFSSVDSGVYQPLMIKLS-g..........
A0A0N1KIM1_9GAMM/1-126             .............................MKK.TLGTLCLLYLSCSGQ.ATTLNVEKNSLSVETFSSKNGTLVINGQAL.YERKLAITVVNRGESKVELTgfS..GCYKAFDKQGKRYVARTT.....QLDL-LGSIEKNAAKWGEISIVGKDDSVYKAIFVEWS-s..........
S3J1Z3_9ENTR/1-123                 .............................MKVlTLVSSLALASFCFSA.V---AATPENIAVYATHKSTGSMSVGGKSA.YTNTFEVMVANVSDKDIDLS..K..VCLKAISPDHKEFKLDTV.....DEALAKGQLKAGKMAKGIAVFASEDAKVNDALLITL--sg.........
W1JCY7_9GAMM/1-123                 .............................MKVsTLVASVALAGFCFTA.H---ASALDNVAVYSTEKSNGSISVGGKNA.YTKSFEVAVANLSDKDIDLS..K..LCLKAYSPDKKEFSLDTV.....DEDLNQGTLKAGKSVKGIAVFASENDVVHKAALIKISD...........
A0A0J9BH82_9BACT/1-122             ........................mkrnq---.-----LALFFTAILS.FSAVAAKTDSIAVIATQQEIGSISTGAKQV.FTKRFEVTLANLSDKAINLR..N..LCLTALSPDDKRFKLDTV.....DDALLSGQLPAQGNHKGLAIFSADDASVYQAVIVKISD...........
D8MW40_ERWBE/1-120                 .............................MKK.ILMLALLMVGVPAYA.NQLFQPGP----IYATNEDVGSMTDHNKAQ.YMVSYRISIFNPLDSAATLS..K..GCFVLFNRAGKEIVARGV.....ELNL-QQEFAPGESKTGTVYFFSDNEAIYTLPFVKWIE...........
#=GC SS_cons                       .............................XXX.--XXXXXXXXXXXXX.XXXXXXXXSSEEEEEEEEEEEEEEETTEEE.EEEEEEEEEEE-SSS-EE-T..T..-EEEEEETTS-EEEEEEE.....-GGGG-SEE-TT-EEEEEEEEEESSSGGGGEEEEEEES...........
#=GC seq_cons                      ......................................lhhhuhshhu.s...Ass.-slhVhuTpcspGohshusKst.ao+oFclslsNhuspcl-Lo..p..hCLKAhsscsKcFcLDTl.....D-sLssGpLK.GpslcGhAlFuSccpsVapAshVKlo............
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