#=GF ID   DUF4858
#=GF AC   PF16150.9
#=GF DE   Domain of unknown function (DUF4858)
#=GF AU   Chang Y;0000-0002-2418-3433
#=GF SE   Jackhmmer JCSG target GS13329B
#=GF GA   22.00 22.00;
#=GF TC   22.20 22.10;
#=GF NC   21.60 21.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF DR   INTERPRO; IPR032338;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of uncharacterized proteins around 190
#=GF CC   residues in length and is mainly found in various Bacteroides
#=GF CC   species. The function of this family is unknown.
#=GF SQ   45
#=GS R5BZN3_9BACE/22-197       AC R5BZN3.1
#=GS A0A5C6HML5_9BACT/22-202   AC A0A5C6HML5.1
#=GS U6RG08_9BACT/22-127       AC U6RG08.1
#=GS A6LBC2_PARD8/26-92        AC A6LBC2.1
#=GS E5CFG1_9BACE/24-95        AC E5CFG1.1
#=GS A0A174DRF2_9BACE/21-144   AC A0A174DRF2.1
#=GS R7EKL5_9BACE/22-202       AC R7EKL5.1
#=GS A0A0F5JBG8_9BACT/14-61    AC A0A0F5JBG8.1
#=GS A0A1M5FRD9_9BACE/128-174  AC A0A1M5FRD9.1
#=GS A0A374WC86_9BACE/22-136   AC A0A374WC86.1
#=GS A0A174N8U3_9BACE/21-213   AC A0A174N8U3.1
#=GS A0A416A278_9BACT/23-90    AC A0A416A278.1
#=GS A0A108T741_BACSE/22-201   AC A0A108T741.1
#=GS A0A1Y4HNK1_9BACT/22-105   AC A0A1Y4HNK1.1
#=GS R6MJV7_9BACE/23-127       AC R6MJV7.1
#=GS A0A6F9ZFV0_9BACT/22-118   AC A0A6F9ZFV0.1
#=GS R6D7C8_9BACE/24-89        AC R6D7C8.1
#=GS R5JLP8_9BACE/22-202       AC R5JLP8.1
#=GS R6FI27_9BACE/22-201       AC R6FI27.1
#=GS A0A374V7D2_9BACE/22-203   AC A0A374V7D2.1
#=GS A0A1M5FR28_9BACE/21-93    AC A0A1M5FR28.1
#=GS Q8A7G8_BACTN/25-217       AC Q8A7G8.1
#=GS A0A8G2FA38_9BACT/30-136   AC A0A8G2FA38.1
#=GS Q5LFH8_BACFN/20-212       AC Q5LFH8.1
#=GS I9GIJ1_9BACE/22-201       AC I9GIJ1.1
#=GS A0A3L8A9H9_9BACE/25-217   AC A0A3L8A9H9.1
#=GS E6SQA8_BACT6/22-208       AC E6SQA8.1
#=GS Q8AA26_BACTN/24-121       AC Q8AA26.1
#=GS W4P563_9BACE/1-164        AC W4P563.1
#=GS A0A174DRF2_9BACE/130-176  AC A0A174DRF2.1
#=GS A0A069D1L4_9BACE/21-197   AC A0A069D1L4.1
#=GS W4URS7_9BACE/21-211       AC W4URS7.1
#=GS R6EBN8_9BACE/25-217       AC R6EBN8.1
#=GS A0A1M5FRD9_9BACE/25-142   AC A0A1M5FRD9.1
#=GS F3PY48_9BACE/22-202       AC F3PY48.1
#=GS S8GR05_9BACT/38-137       AC S8GR05.1
#=GS A6L178_PHOV8/27-117       AC A6L178.1
#=GS U6RD52_9BACT/27-111       AC U6RD52.1
#=GS K5ZWE0_9BACT/23-82        AC K5ZWE0.1
#=GS Q5LBK2_BACFN/25-77        AC Q5LBK2.1
#=GS R6LEL9_9BACE/22-202       AC R6LEL9.1
#=GS A0A3P2AA36_9BACE/22-201   AC A0A3P2AA36.1
#=GS A0A415DN91_9BACT/22-107   AC A0A415DN91.1
#=GS A6L6D8_PHOV8/22-124       AC A6L6D8.1
#=GS E5CCU6_9BACE/14-206       AC E5CCU6.2
R5BZN3_9BACE/22-197                  ..............DWTKADSLRLQQLLQSDGEIILNLDILKEVD-......E......T.PWG......SPK.....TVESKPWLEVDETL...PA..V.QGI.R..PRKVK...LTLFPYTANTPYNWDPVRQRKIKIDKNTWRNDPFYELKTRTIYSNWAKSPLDAG..PRETV.EQIEATGLRYVVMGRMANQSVLGWQAISRP....---.......---.--S.GYSLMP--DKGAWSIRARKRRAR................................................................
A0A5C6HML5_9BACT/22-202              ..............NWTPEDSLKLDRLLKGDGELKINTNALKELEI......H......S.GFG......TQS.....MSLEKKWLNFDNTL...PS..V.PGV.P..EKKIV...LTLHPYTANTRYNWDPVYQKKIKVGKDTWRDEPFYALYKTNIPSNWAKKPFDPG..IRKSV.EEIEATGLRYT--SYLDGPTMINA---WRP....-AG.......GGG.GIG.GLDLMTIFTKDFWDVKGRKRRAR................................................................
U6RG08_9BACT/22-127                  ..............QWSKQDSLRLQQLLNGEEELIINKEAVKSIHFdfkptkD......A.IQG......SPM.....ISQDKPWMKFLDAL...PK..N.FGD.T..TQWIKpqyVRFTPYTPYTRWDEDPVNDPII--------------------------------..-----.------------------------------....---.......---.---.-----------------------tnekelkis.......................................................
A6LBC2_PARD8/26-92                   ..............QWTEQDSLRLQEFLSGKEEIRLNPEFQKAIES......G......T.---......---.....--------------...--..-.---.-..-----...------------------------------------------------------..-----.------------------------------....---.......---.---.-----------------------flrpdqpgthmlsspselpitkdfseyvqldtl...............................
E5CFG1_9BACE/24-95                   ..............EWNKQDSLRLQQMLESDQEIKINRKFIEKVE-......-......-.---......-QN.....MYSRKPFVDFDPTL...PT..L.KS-.-..-----...------------------------------------------------------..-----.------------------------------....---.......---.---.-----------------------smifskpsirtyqtflkpgs............................................
A0A174DRF2_9BACE/21-144              ..............QWSAQDSLKLQKLLEGSEELKLNPKAVKQIDF......G......G.AVG......TPR.....MSEEKRWMLPDESL...PE.aL.PK-.-..-PKVV...LTLMPYKANTRYNWDPVYQKKIRVNKNTWRGDSFYELCRQRFYTNRTRSRKA--..-----.------------------------------....---.......---.---.-----------------------neiriged........................................................
R7EKL5_9BACE/22-202                  ..............NWTPQDSLRLNRLLKGEGEVKLNPEVLQELEM......N......N.SLG......TPK.....AVMDKSWMDFDNSL...PV..M.PKA.P..EKKVV...LTLRPYTANTKYNWDPIYQKKIKVDKDTWRGDEFYALKILMIPTNWAKHPFDAG..PRETV.EQIEATGLRYR-VTERANNMAVGG------....WQG.......ASGgGIS.GLDLMTPFTREFWNFKGRKRRAR................................................................
A0A0F5JBG8_9BACT/14-61               ..............QWTEKDSVWLQNIISGKEKIELNPEALKAIES......G......T.LIN......TDK.....--------------...--..-.---.-..-----...------------------------------------------------------..-----.------------------------------....---.......---.---.-----------------------pasnmima........................................................
A0A1M5FRD9_9BACE/128-174             llytkssnislgeg--------------------------------......-......-.---......---.....--------------...--..-.---.-..-----...------------------------------------------------------..-----.------------------------------....--Gv....yiSGG.AIG.GLDLMAMFTRDFWSKKRLETRDR................................................................
A0A374WC86_9BACE/22-136              ..............QWTSQDSLKLQKFLSGEKELKLNAEEIGNIRL......E......S.PSLekpfdlSPL.....MDTEKPSLKFKTNL...PTyfT.DSIpR..KRRIY...LTLHPYGIFTGYDENPVT------------------------------------..-----.------------------------------....---.......---.---.-----------------------gqsyiypmavkfslrngpvrny..........................................
A0A174N8U3_9BACE/21-213              ..............QWSVQDSLKLQKLLESSEELKLNPKAVRQIDF......G......S.AVG......TPR.....MSEEKSWMLPDESL...PE.aL.PK-.-..-PKVV...LSLMPYKANTRFNWDPVYQKKIRVDKNTWRGDPFYEIRHQRSYTNWARNPMAKG..IRKSL.EEIQASGVWFRQLSERANGMMVNSVVMDSPi..pLFGgsg.vyiNGG.TIG.GLDLMAVFTKNFWDKKGRDRCER................................................................
A0A416A278_9BACT/23-90               ..............QWTKKDSVWLQNVLSGKEKLELNPETMKAIQS......G......S.FIN......LD-.....--------------...--..-.---.-..-----...------------------------------------------------------..-----.------------------------------....---.......---.---.-----------------------epasnmklspvtplpiikdfseyiqtdst...................................
A0A108T741_BACSE/22-201              ..............EWTPQDSLRLHRLLDGGGEMKLNPDVLKEMGV......D......A.PLG......SPK.....ADVSKTWMDFDASL...PA..M.PRM.P..EKKVV...LTLRPYTANTKYNWDPVYQKKITVNKNTWRGDPFYELTRLKIYTDWAKRPLDAG..PRESI.EQIEATGLRYM-VTERANNMAVGS------....WRS.......VGGgGIA.G-DFMRPFTKDFWNRKAARRRAR................................................................
A0A1Y4HNK1_9BACT/22-105              ..............NWTPEDSLRLQQMLKKEGEIRLNQEALRELE-......K......S.FGG......VQH.....SSEDKPWLEPNTTL...PA.dV.YGR.T..VLKRR...M-----------------------------------------------------..-----.------------------------------....---.......---.---.-----------------------pllnlndqsvyqsevdt...............................................
R6MJV7_9BACE/23-127                  ........lsaqte--------------KKEEEIKLNEDAIKMIQF......D......F.VPN......ENRyqplnAPMDKKWMQFKEDLs.mPRsmI.DST.R..VKKITg.yIRAEPYTIWTKFGENPVYDVMPTIE-----------------------------..-----.------------------------------....---.......---.---.-----------------------kkwkiywninp.....................................................
A0A6F9ZFV0_9BACT/22-118              ..............QWNKQDSIRLQELLNKDGELKINTEAVKSIHFdfksdkD......D.IKG......TPL.....MPEDKPWMKFLKDL...PK..N.FGD.T..TKWARpkfVRLTPYTPYTTWHEDPVN------------------------------------..-----.------------------------------....---.......---.---.-----------------------dpif............................................................
R6D7C8_9BACE/24-89                   ..............EWSKQDSLRLQQILNSEQEIKINRKLIENTE-......-......-.---......-QN.....IFPKKSFMDFDPTL...PT..I.KS-.-..-----...------------------------------------------------------..-----.------------------------------....---.......---.---.-----------------------stifskpsintyni..................................................
R5JLP8_9BACE/22-202                  ..............EWTKKDSLNLSRVLKEEGEIKLNPEAVKQIDF......G......SdIMG......TPL.....MSTEKNWMLPDESL...PS.aL.PNT.LplEKRQM...LSLHPYKANTPYDWDPVYQKKIQVGKDTWRGDPFYRIKTFRGYTNTSKAPLRVMviTQPSL.TEIEAIKLQYKPLFGQSNGSMAGV------....---.......---.AIG.GFNFMYVFTKDFWDKKGRERRAR................................................................
R6FI27_9BACE/22-201                  ..............NWTAQDSLRLQKLLDGEKQPELNPEAIEELFH......G......K.LMG......NQK.....LSKQKKWLDFDETL...PT..A.PKV.S..TEKVV...LTLYPYKPNTPYNWDPVYQKKIHVDKDTWRG-PFYQLKTLKTPTNWAKNPLDAG..LRESV.EQIEATGLRYR-ATERLNNMMVGT------....WQS.......TAGcGVG.GLDLMLPFTREFWSFKKRKIRKR................................................................
A0A374V7D2_9BACE/22-203              ..............NWTTQDSLRLQQLLKGEGEVKLNPDVLKEIDM......G......S.PFG......TPK.....AAVNKPWLDFDDTL...PV.sL.PGE.P..KKTIK...LSLRPYSANTKYNWDPIYQKKIEIKKDTWRGEPFRELTTRFIYTNWAKTPSDPG..PRETV.EQIEATGLRYR-VTERVNNMAVGS------....WQG.......AGGgGIG.GLDLMTPFTREFWNFKGRKRRAR................................................................
A0A1M5FR28_9BACE/21-93               ..............QWTAEDSLRLKKSLENGEELYLNKEVVKRIKF......D......N.SAE......NPR.....MSNEKSWMRFDKSL...PR..V.I--.-..-----...------------------------------------------------------..-----.------------------------------....---.......---.---.-----------------------apstvvesdssydsr.................................................
Q8A7G8_BACTN/25-217                  ..............EWTKEDSLRLRKLLDSDQELNLNQDAVRQIDF......G......S.AVG......TPR.....MSVEKKWMLPDESL...PE.aL.PK-.-..-PKVV...LSLMPYKANTPYNWDPVFQKKIRMDKNTWRGDPHYEMRHQRSYSNWAHNPMAGG..VRKSL.EEIRASGVRFRQLSERANGMMVNSVVMDSPi..pLFGgsg.vyiNGG.TIG.GLDLMAVFTKNFWDKKGKERRER................................................................
A0A8G2FA38_9BACT/30-136              ..............QWTKKDSARLQNILSGKETLQLDPEVQKAIEN......G......T.FLN......FDK.....PAD-----------...--..-.---.-..-----...------------------------------------------------------..-----.------------------------------....---.......---.---.-----------------------qmrmsttpltiikdfseyleiddtikhkrialkdlppavfmrygldkplpkqgmmvnsriield
Q5LFH8_BACFN/20-212                  ..............QWTAKDSVNLQRILNGKEDIKLNMDAVKQIDF......N......S.SPT......VPK.....MSKERPGLRLDETL...PQ..V.LE-.-..KKKVV...LTLRPYTANTKYNWDPIYQKKIRVDADTWRGDPFVEL-YQTVPSNWAKNVYDKG..IRSSY.EEIRSSGLRHNLFGERANGMMVPTQSMVHTs.amKLGksg.vtvNGG.TIG.GLDLMTIFTKDFWDKKGRNRRSR................................................................
I9GIJ1_9BACE/22-201                  ..............EWTTQDSIKLNRILQGSEEIKLNPEAVKQIDF......G......SdVMG......TPL.....MSTEKSWMLPDATL...PS.vL.PNT.LplNKRQM...LTLHPYKPNTPYDWDPVYQKKIKVGQDTWRGDPFYRIKTLRSYTNMEKVPQKPK..RTGGVpSDIEAVNLRYNPLIGQANGAMAGV------....---.......---.GIG.GLDFMSIFTKDFWDVKGRERRGR................................................................
A0A3L8A9H9_9BACE/25-217              .............v-WTAQDSLHLKKLLDSDQELHLNMDAVKSIDF......G......G.AVG......SPR.....MSEEKNWMLPDESL...PE.aL.PK-.-..-PKVV...LSLMPYKTNTRFNWDPVYQKKIRVDKNTWRGDPFYELRHQKSYSNWARNPMAKG..MRKSL.DEIQASGVRFRQLSERANGMFVNSVVMDSPi..pLFGgsg.vyiNGG.TIG.GIDLMAVFTKDFWNKKGRDNRAR................................................................
E6SQA8_BACT6/22-208                  ..............NWTSQDSLKLQQLLKGDGEVKLNRNALKELE-......K......S.IRG......VPE.....MSVDKPWMDFDTTL...PA.sL.PGE.P..KKLIR...LSLRPYTANTKYNWDPVYQKKIKIDENTWRGDEFYKLKTLTIPTNWAKKPSDAG..SRETL.EQIEATGLRYR-VTERANNMAVGGWQGADG....VGA.......GGGvGIG.GLDLMVPFTREFWNFKGRKRRAR................................................................
Q8AA26_BACTN/24-121                  ..............EWSKQDSLRLQQTLNSEQEIRINKVFVKKTE-......-......-.---......QNM.....LYHTKPFVDFDPTL...PI..L.KS-.-..-----...------------------------------------------------------..-----.------------------------------....---.......---.---.-----------------------tiispklpfhthnifrqtnstflptysrlkinknitlhsksnfse...................
W4P563_9BACE/1-164                   ..............-------MKLRKMLEADGELRLNRKALRSIDF......S......V.GTA......DPR.....ISEEKRWLSPDESL...PS.vL.PK-.-..-AVPV...FSLMPYTPTTRYDWDPVFRKKIRVTKDTWRGDPFAHLYARTG---YKPNTINLG..KGVT-.----GRGTL-----QRGAD-FVPPHVAVHC....-YG.......AAGvAIG.GLDLMLVFTKDFWDRKGKKRRAR................................................................
A0A174DRF2_9BACE/130-176             ...........rtr--------------------------------......-......-.---......---.....--------------...--..-.---.-..-----...------------------------------------------------------..-----.-------------SRKANEIRIGE-DVS--....--V.......CGG.TIS.GLDLMAAFTKEFWNKTGRDNRIR................................................................
A0A069D1L4_9BACE/21-197              ..............QWTGKDSINLKRLLEGDGEIKLNQEAIKQVQ-......-......Q.ALG......SPL.....IIRESSATKYDESL...PK..V.YP-.E..KEKLV...LTLMPYTARTKYNYDPIYKKKIDVKADTYKSNPFETLYALSIPTNWAKHPFEGG..YRKSL.EEIEATGLKYNPLAEGANNKAVGA------....WKS.......AAG.P-T.GYDFMTPFTKDFWNIKGNKRKAR................................................................
W4URS7_9BACE/21-211                  .............q-HTVSDSLKVKRLLEDTREVKLNPEAAKMIDF......G......S.GAG......SPR.....VSGEKNWMLPDETL...PQ.aL.PK-.-..-PKVV...LSLMPYKANTAYNWDPVYQKKIRVDKDTWRGDPFYALRRQRSYTNSDSKEQDVA..MD---.-MRWQGGARTQLFGERANGSMVSTMTTGKAlplyT-KgstkvtiSGG.NIG.GLDLMAVFTKNFWDKAGRRQRER................................................................
R6EBN8_9BACE/25-217                  .............v-WTAQDSLHLKKLLDSDQELHLNMDAVKSIDF......G......G.AVG......SPR.....MSEEKKWMLPDESL...PE.aL.PK-.-..-PKVV...LSLMPYKANTRFNWDPVYQKKIRVDKNTWRGDPFYELRHQRSYSNWARNPMAKG..MRKSL.DEIQASGVRFRQLSERANGMFVNSVVMDSPi..pLFGgsg.vyiNGG.TIG.GLDLMAVFTKEFWNKTGRDNRAR................................................................
A0A1M5FRD9_9BACE/25-142              ..............EWTSKDSLHVKKLFDGEQELILNPDVVKSIDF......G......N.AAG......TPR.....VSEEKSWMHFDESL...PQ.vL.PK-.-..-PKVV...LTLTPYTATTPYDWDPVYQKKIRVTKNTWRGDPFYELRQL--------------..-----.------------------------------....---.......---.---.-----------------------lytkssnislgegg..................................................
F3PY48_9BACE/22-202                  ..............NWTPQDSLKLQQLLKGNGEVKVNPDALKELE-......R......N.ILG......TPE.....VSVNKSWMDFDPTL...PT.sL.QKE.P..KQEIK...LTLRPYTANTKYNWDPVYQKKINVGKNTWRGDPYYELKTLFIYTNWAKTPLDIG..PRESV.EQIEATGQRYR-VTERANNMPVGS------....WQG.......VGGgGIG.SLDLMTPFTREFWNFKGRRRRAR................................................................
S8GR05_9BACT/38-137                  ...........vln----DDSLKLKRIFENKGEIKLNGEAINAIDF......DyldeepS.MLD......APK.....LTENQNHLQFREEIiksPV.fVkEEQ.R..GKGIT...MELNP-------------------------------------------------..-----.------------------------------....---.......---.---.-----------------------nshsdvyrqtehdiknrri.............................................
A6L178_PHOV8/27-117                  .............q-LTKQDSLRLQQLLSGQVEIVIDDETQKEIDR......Lf...npE.KWK......MKS.....TPFPKKNMKFETEL...PR..Y.---.-..-----...------------------------------------------------------..-----.------------------------------....---.......---.---.-----------------------yisqmdtidgrgyirllpygpfetpeeeqiy.................................
U6RD52_9BACT/27-111                  .............q-LTRQDSLRLQQLLNGQVEIVIDDETQQEIDR......Lf...npE.KWK......MKS.....TPFPKKNMKFETEL...PRyyI.SQ-.-..-----...------------------------------------------------------..-----.------------------------------....---.......---.---.-----------------------vdtvdgrgyirllpygpfesp...........................................
K5ZWE0_9BACT/23-82                   ..............QWTKKDSVWLQNVLSGKEKLELNPETMKAIQS......G......S.FIN......L--.....--------------...--..-.---.-..-----...------------------------------------------------------..-----.------------------------------....---.......---.---.-----------------------depasnmkispvtplpilkdft..........................................
Q5LBK2_BACFN/25-77                   .............v-WTQNDSLMLKKILAGQAEIRINREALRELD-......R......A.FSS......P--.....--------------...--..-.---.-..-----...------------------------------------------------------..-----.------------------------------....---.......---.---.-----------------------rrlfksqsrsaillik................................................
R6LEL9_9BACE/22-202                  ..............NWTPQDSLRLRRLLDGEGEIKLNPEVLKEMGV......Q......E.PLG......KQQ.....ISMEKQWLDFNTTL...PE..I.PNT.P..KKKVV...LTLRPYTATTKYNWDPVYQKKIKIDKDTWRGDPFYELKILRIYSDWAKTPFEKG..VRKSM.DEIEATGMRYR-MTERANNMAVGS------....WQG.......ASG.GLGfSGDFMAPFTKEFWNVKGRKRRAR................................................................
A0A3P2AA36_9BACE/22-201              ..............NWTPQDSLRLQQLLRGKGEIKLNPEVLKELDA......T......T.PLN......NPK.....AETHKSWMDFDASM...PV..L.PRV.S..EQKVK...LTLRPYTANTRYNWDPVYQKKIKIDKNTWRGDEFYALKTLLIPTNWAKSPFDAG..PRETI.EQIEATGLRYR-MTERANNMAVGG------....WQG.......VSG.KPS.GIDLMTPFTKEFWDYKGRKRRAR................................................................
A0A415DN91_9BACT/22-107              ..............QWTKKDSVWLQNVLSGKEKLQLNPEAMEAIKS......G......S.LIN......LEK.....--------------...--..-.---.-..-----...------------------------------------------------------..-----.------------------------------....---.......---.---.-----------------------pdlemqmipvtplpiikdfseyiqpdssrrkvalkdlppsvfwryn..................
A6L6D8_PHOV8/22-124                  ..............QWNKQDSIRLQELLNGDGELKINTEAVKSIHFdfqsdkD......N.IKG......TPI.....MSEDKPWMKFLKDL...PK..N.FGD.T..TKWVRpnfVRLTPYTPYTTWHEDPVN------------------------------------..-----.------------------------------....---.......---.---.-----------------------dpiflkrkds......................................................
E5CCU6_9BACE/14-206                  .............v-WTAQDSLHLKKLLESDQELHLNMDAVKSIDF......G......S.AVG......TPR.....MSEEKSWMMPDESF...PE.aL.PK-.-..-PKVM...LTLMPYKANTRYNWDPIYQKKIKIDKNTWRGDPFYEIRHQRSYSNWARNPMAKG..MRKSL.DEIQASGVRFRQLGERANGMMVNTVVMDAPi..pLFGgsg.vyiNGG.TIG.GLDLMAVFTKDFWNKTGRDNRAR................................................................
#=GC seq_cons                        ..............pWTtpDSL+LpplLpuctEl+LN.-slKpI-h......s......s.hhs......ssp.....hs.cK.Whp.-poL...Pp..l..t.......hhh...lpLhPYp..T.ap.sPl........................................................................................................................................................................................
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