GenomeNet

Database: Pfam
Entry: DUF5373
LinkDB: DUF5373
Original site: DUF5373 
#=GF ID   DUF5373
#=GF AC   PF17343.3
#=GF DE   Family of unknown function (DUF5373)
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   PRODOM:PD035609
#=GF GA   28.70 28.70;
#=GF TC   30.70 32.00;
#=GF NC   27.10 26.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR035321;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family of unknown function is found in Caenorhabditis.
#=GF CC   Members of this family are predicted to contain 4 trans-membrane
#=GF CC   regions.
#=GF SQ   31
#=GS A0A261C6V9_9PELO/5-188    AC A0A261C6V9.1
#=GS YLH9_CAEEL/3-177          AC P34363.1
#=GS YLH0_CAEEL/1-179          AC P34364.2
#=GS E3LSC5_CAERE/9-135        AC E3LSC5.1
#=GS A0A2G5UHA3_9PELO/4-165    AC A0A2G5UHA3.1
#=GS A0A2H2J2B9_CAEJA/1-50     AC A0A2H2J2B9.1
#=GS A0A2H2I2L9_CAEJA/1-105    AC A0A2H2I2L9.1
#=GS B6IHL7_CAEBR/1-177        AC B6IHL7.1
#=GS G0MK62_CAEBE/4-179        AC G0MK62.1
#=GS G0MK60_CAEBE/1-154        AC G0MK60.1
#=GS G0MK59_CAEBE/1-184        AC G0MK59.1
#=GS A8XA93_CAEBR/1-186        AC A8XA93.1
#=GS A0A261C6U2_9PELO/1-151    AC A0A261C6U2.1
#=GS E3LSC9_CAERE/1-175        AC E3LSC9.1
#=GS A0A1I7UQL7_9PELO/1-185    AC A0A1I7UQL7.1
#=GS A0A2G5UIA9_9PELO/1-186    AC A0A2G5UIA9.1
#=GS A0A2G5UHD3_9PELO/3-156    AC A0A2G5UHD3.1
#=GS A0A2G5UHL6_9PELO/5-174    AC A0A2G5UHL6.1
#=GS A0A261C6P8_9PELO/235-413  AC A0A261C6P8.1
#=GS A0A2G5UHY7_9PELO/5-183    AC A0A2G5UHY7.1
#=GS A0A261C6T5_9PELO/1-175    AC A0A261C6T5.1
#=GS E3LSC4_CAERE/1-179        AC E3LSC4.1
#=GS A0A2G5UHB9_9PELO/1-177    AC A0A2G5UHB9.1
#=GS A8XA96_CAEBR/1-151        AC A8XA96.1
#=GS G0MK63_CAEBE/1-184        AC G0MK63.1
#=GS YLH6_CAEEL/11-169         AC P34360.1
#=GS E3LSC6_CAERE/5-188        AC E3LSC6.1
#=GS A0A2G5UHB1_9PELO/1-151    AC A0A2G5UHB1.1
#=GS A0A2G5UH99_9PELO/1-165    AC A0A2G5UH99.1
#=GS YLH7_CAEEL/1-153          AC P34361.1
#=GS E3LSC8_CAERE/1-104        AC E3LSC8.1
A0A261C6V9_9PELO/5-188               .....tkfsdsksepnv----------VQKKKEPMLLG-LSV..KHLILLYHMVFFLMQID.SFIR....TN....KKLGD.IVW....GIITIICISGSFCGILTENKKYIKFHYWYCIFVSA...IPVAFLQLLSFGVIHRL....VTGEe....gcLSGEMVITLK.AF...GYVFGF.VMIF...FLYIWMCYKL.HKHLAS.HSMVLPySAKDVHVIYNPNYDAN----------hhsinsh........................
YLH9_CAEEL/3-177                     ..........nnysidl-------------KQGPSLLYVIPI..KPVVLAVQLGAILFQFK.SIYD....FE....YNFVGdLVF....RTFVIFLSLTSFTAFLFNQKILMKAHLVMAIFLLA...GPIACLQYLVFDFYRAE....FHGDnn..lkwDHTSSFENYL.IF...ILVILL.AVAL...GSYTWLCHLL.IEGLDE.KN----.--------------------------apkrrpqckicsnhyvvpenekl........
YLH0_CAEEL/1-179                     .................MSKFYDPSQPEQSYDSPKLFGIIPI..KFIVSFLQLVSIVSQIL.WLY-....SE....NDKIY.LVL....LSVGIVLNVFTVVVFIKEHKLLMRAHYYSALIFTV...VPFI-YAVYTFISFIEL....FFGD.......-KDITFNQCS.PF...AYAFIF.LCIY...IFYLAMCRVL.IKASEF.QPDDMP.DLDTTQGLFHYNRDAYDGGERAKLMY...............................
E3LSC5_CAERE/9-135                   .............lakk--------------KGPMFFGVLPM..KSVILFMQFLAIFYQTYqFQDC...fGC....FLSTV.YLI....RIILIAVSFIGFIGYLLDRKTVMKVHLWTTIFVLA...IPVAIIQIGVFLY----....----.......----------.--...------.----...----------.------.------.--------------------------ctflyicwtissehvisledvlqksasemsl
A0A2G5UHA3_9PELO/4-165               .......isrppklmtw------------------------I..GAIVYSVQALFLIFQF-.WEYV...nKKydpnQSHMQ.MIIelirRIVMIFISGIVFVGFVTEEKVIMKIHILFMTSLLA...IPIT-TLFATVFSFFKS....LEGG.......A-MLINNDGA.KC...INIEGV.MCN-...LLYITFCYIL.LADIKYgHPGVLP.Y-------------------------tskvhgssqdsek..................
A0A2H2J2B9_CAEJA/1-50                ................x-------------------------..-----------------.----....--....-----.---....-----------------------------------...-----------------....----.......----------.--...------.---L...LFYIWMCYKL.VKAVKR.KTVHLP.EFDTTQGLYQFNRDAYDGVETVTLNY...............................
A0A2H2I2L9_CAEJA/1-105               ..........mqvhfca-------------------------..-----------------.----....--....-----.---....--------------------------ILFALVMTL...FGFGITGALYLYTLIKS....K--D.......GRFGDDGELN.RL...IANFII.LVSL...LFYIWMCYKL.VKAVKR.KTVHLP.EFDTTQGLYQFNRDAYDGVETVTLNY...............................
B6IHL7_CAEBR/1-177                   .................MAHFYEP-RDSRLSKAPLCCCCIPI..KFIVLLVQVLALVFQI-.WLLC...aEK....TSNVM.LFV....KVLLAVYTAFTFGVFLIEHKSLMNFHCFLGVICLL...APFA-HVALEYFASAKK....LFLH.......YDYSPKTDV-.-F...VIVGII.MLVV...LVYLTMCRAL.VNELN-.KQNQLPsYVAATQPSFNTEYMP-ELTEKTKLIH...............................
G0MK62_CAEBE/4-179                   ................k-PKFQDLKQSQAIKEEPKFVAFLDNadKVFVLVLQAVLLGHLIYqYVVD....EV....YASKE.WIS....SSIAIGFLAIIFIAFLFEKKSIIVAYSYSLALMAA...IPIGRIELLAADILKKL....FNPDap..vldGPNAMWNASI.II...MWNLII.LLAL...GLYLSVCFAV.IDNIDL.KKK---.--------------------------kksmtlphtvqnvil................
G0MK60_CAEBE/1-154                   .................MSKFYET-HFSRSLDSPLLCGCFPI..KPIVLAAQLLMTIFFIH.DLVGt..aSS....ADTVS.IMG....KVFMIIFLVSSFVAFLADYEVLMRLHHLVSCVVAL...IHIA-WFFMELFSFIKK....VASE.......-TPINSSDVK.VL...LVPIGY.SFVF...VLYIWMCQQL.IMVLG-.------.--------------------------rkyilp.........................
G0MK59_CAEBE/1-184                   .................MPSYYNPHHPN-VYESPKICCCIPI..KLIVLAIQAAALVFQVY.QICCgierSP....SDKGA.LFL....QFLAALYTGFTFVVFLINHRCLMCTHFCFGICLMM...IPLGFFVYYSFFVVLPG....VLGL.......IDRVGANDIE.QF...FAAGFC.ILVL...FSYIVMCKVL.IDSLNH.SP-LLP.EH------------------------iinqntqqpghiggghsegsqliy.......
A8XA93_CAEBR/1-186                   .................MVKFYDPSQPEQYLSSPKLFGVLPI..KLIVISMQILYMLLQIV.WLTA...sGV....TSKVS.ILL....VIASVILTAFTVAVFVVENKSLMQAHIWVASLFLF...FPLAVFVLMIAQFFFDI....KFLAt....ffGEGIYTHPIT.SL...TVAAVF.LCAY...IAYLFLCHKL.VEAKDQ.QPDDFP.ELDTTQGLFHYNRDAYDGSERVNLIY...............................
A0A261C6U2_9PELO/1-151               .................MSNFYQT-RVINSMESPMLFDLFPI..KLVVLVVQAVTLLLNIG.FISK....LS....LERGD.FIF....EICIILFLVASIVAFLADYELLMHIHYWVVCVLTI...IPLIYWGIAVKELYDSI....G--S.......-SKIAVN---.GI...ISQTLV.LLAY...VIYISMCRRL.IKSLGR.K-----.--------------------------yvlpmfn........................
E3LSC9_CAERE/1-175                   .................MPRFYDA---SSYSEPPKVC-CIPV..KLVVLFMQIAALILPIA.SICF...aRN....QESHL.LFG....QVLWAIYFGLSFVAFLVEHKGFMVLHCFFGIACWLgacVVIGLEYFKIRVFSDKP....IFNG.......--QFFSNSI-.LL...VGTGIL.LFVA...LFYIIMCSAL.VRSLGR.-EPVLP.DYNTAM---QQPTCPVDTSEHTKLIY...............................
A0A1I7UQL7_9PELO/1-185               .................MIKFYDPNQPGQFQDVPKFLGVVPV..KALVLTMQLIFLMFQIL.FLYS....SD....FRGLT.ALM....HTILIILFAFVIAGFFFENKLTIRAHYYFAILCLA...ISVFSLAAFILVVSIGL....SVSLe.....dLGIKQTINQF.VL...IFWWIFgICLH...VFYIIMVRRL.VNAMY-.KRSEYPdDLDTTQGLFRYNRDAYDGAENAKLIY...............................
A0A2G5UIA9_9PELO/1-186               .................MAKFYDPSQPEQYLSSPKLFGVLPI..KLIVISMQILYMLLQIV.WLTA...sDV....TSKVS.ILL....VIASVILTAFTVAVFVVENKSLMQAHIWAASLFLF...VPLAVFVLIIAQFFFDI....KFLAt....flGEGIYTHPIT.SV...VVAAVF.LCAY...IAYLFLCHKL.VEAKDQ.QPDDFP.ELDTTQGLFHYNRDAYDGSERVNLIY...............................
A0A2G5UHD3_9PELO/3-156               ...............wt-------------------------..KSFVFSVQAVFLFLQI-.WALAh..fDF....EKNTQ.LIP....RLIMLIVSAIVFIGFLIEQKIIMTVHILFMASFLA...WPIFLLQATILSLFKSLegkaAFIN.......TEGPSTGSMVeTS...VTLFLF.SLLN...LVYIACCYNLlVDIKHG.HPEVLP.YNSK----------------------vhgssqasek.....................
A0A2G5UHL6_9PELO/5-174               tkfshpqksekksnmsw------------------------T..KSFVFSVQAVFLFLQI-.WALAh..fDF....EKNTQ.LIP....RLIMLIVSAIVFIGFLIEQKIIMTVHILFMASFLA...WPIFLLQATILSLFKSLegkaAFIN.......TEGPSTGSMVeTS...VTLFLF.SLLN...LVYIACCYNLlVDIKHG.HPEVLP.YNSK----------------------vhgssqasek.....................
A0A261C6P8_9PELO/235-413             .................MPKFYDPNQPEQYLEAPTFFGVFPI..KKVVIVMQIIWLSLQIA.FLSF....VD....MAPLL.ILA....NIVSIVLCAFVIAVFVVENKLLMRIHYWNALVFIF...VVMGVLLLGATCILWNV....SAGS.......---FELKFLW.YW...IGGLIF.LCAL...ILYVSLCRKL.IRALDQ.QPDNLP.DLDTTQGLFHFNRDAYDGSERVNLIY...............................
A0A2G5UHY7_9PELO/5-183               ..tkfshpqkvekesnm----------------------SDI..KAFVFAVQATFFIYQI-.WKLA...hFD...yEKHIQ.LIP....RLTMLFLSAVVIIGFLKKQKIIMTVHIWFMASLMA...WPIFMLHAVVFMFFQSL....EDGDlfinsggDTGINMTGYM.YLklaTAVFIF.FLVTlgnLVYIALCYIL.LDDIKYgHPEVLP.YTSMMHGSYQ----------------dsekl..........................
A0A261C6T5_9PELO/1-175               .................MPRVYDA---SSYSEPPKVC-CIPV..KLVVLVMQIAALILPIAsICFA....RK....QESHL.LFG....QVLWAIYFGLSFVAFLVEHKGLMVLHCFFGIVSWVgscVVLGLDYFKIRVLSDEL....FFDE.......--QFFSNSV-.LL...VGTGIL.LFVA...LFYVIMCRAL.VRSLDS.EP-VLP.DYNTA---MQQPSCPVDTSEHTKLIY...............................
E3LSC4_CAERE/1-179                   .................MPKFYDPNQPEQYLKAPTLFGLFPI..KKVVTVMQIIWLSLQIA.FLSF....VD....LAPLL.ILA....NIVSIVFCAFVIAVFIVENKILMRAHYWSALVFII...VVIGVLLFGTTSILLNV....SAGN.......---FELKSLW.YL...IGGLIF.FCAL...VIYASLCRKL.IRALDQ.QPDNLP.DLDTTQGLFHFNRDACDGSERVNLIY...............................
A0A2G5UHB9_9PELO/1-177               .................MAHFYEP-RDSRLSKAPLCCCCIPI..KFIVLLVQVLALVFQI-.WLLC...aEK....TSSGM.LFV....KVLLAVYTAFTFGVFLIEHKSLMNFHCFLGVICLL...APFA-HVALEYFAHINK....FFLH.......RDYSPKTDV-.-F...VIVGLI.MLVV...LVYLTMCRAL.VNELN-.KQNQLPsYVAATQPSFNAEYMP-ELTEKTKLIH...............................
A8XA96_CAEBR/1-151                   .................MSNFYER-RVLHSMESPMLCDFIPV..KLVVLVVQIATLLITVG.VISR...nVS....LSSES.AMF....EIFVVVFLVASVVSFLADYELFMHIHYWVVCVLII...VPLY-YWGQSIVNLYNH....IFNN.......---SESPAVF.SF...ATSTFI.LCSY...IFYIWSCRQL.IISLG-.------.--------------------------rkyvlp.........................
G0MK63_CAEBE/1-184                   .................MVKFYDPNQPEQFLEVPKLCGVFPI..KVLVLAMQFIVMLFQIA.CLCV....FD....SSKTI.IFF....QITSIVLNAFTFAAFIVENKILIRTHYYAAAIFTI...VPIGFVLFSIILMFDVI....FFGNr.....lLTASPFESTF.YL...IAGILV.LCAY...IFYITMCRRL.IKAFDR.QPEDLP.ELDTTQGLFTFNRDAYDGAERVKLIY...............................
YLH6_CAEEL/11-169                    .......ekskatisfw-------------------------..KFIAMFIQALFLIGLVEdLCYY...hMF....YSRQY.FFL....EILVTIHTGFSFIVFLIEHKPLIMLHVGYMTLLTI...IPIA-YMVMQGVEFGIL....IFDD.......YHILVFRDFH.KF...GCSIMF.SLYY...IGYIVVCFLF.IEALEK.KP-VLP.QVYSI---------------------kpklvaavnpsnn..................
E3LSC6_CAERE/5-188                   ....tkfndsksapnvv-----------QKKKEPMLLG-LSV..KHLILLYHVVFFLVQIDsFIHI....KD....KKFND.IVW....GIITVICISGSFYGILTENKKYIKFHYWYCIFVSA...IPVAFLQLLSVGIIHRL....VTGEe....gfLSGEIMCALK.AF...GYVLGF.VMIF...FLYIWMCYKL.HKHLAN.HSMVLPySAKDVHVIYNPNYDAN----------hhsins.........................
A0A2G5UHB1_9PELO/1-151               .................MSNFYER-RVLHSMESPMLCDLIPV..KLVVLVVQIATLLITIG.VLSR...sVS....LSSES.AMF....EIFVVVFLVASVVSFLADYELFMHIHYWVACVLIL...VPLY-YWGQSIVNLYNH....IFNN.......---SESPAVF.SF...ATSTFI.LCAY...IFYLWACRQL.IISLG-.------.--------------------------rkyvlp.........................
A0A2G5UH99_9PELO/1-165               ..............msd------------------------I..KAFVFAVQATFFIYQI-.WKLA...hFD...yEKHIQ.LIP....RLTMLFLSAVVIIGFLKKQKIIMTVHIWFMASLMA...WPIFMLHAVVFMFFQSL....EDGDlfinsggDTGINMTGYM.YLklaTAVFIF.FLVTlgnLVYIALCYIL.LDDIKYgHPEVLP.YTSMMHGSYQ----------------dsekl..........................
YLH7_CAEEL/1-153                     ...........mthfet--------RPLCSLNSPLLCGFFPI..KLAVLLVQLIAIVIQFC.MLYY...nGN....QEEIV.FVA....MVLLLVFTISSFVAFLGEYGTMMAIHYYVSCILLI...WPAVVF-IMKLISLCNK....LFIE.......-ENATSRDAK.DF...MKITAI.LFAV...IFYIWMCLQL.IRVA--.------.--------------------------ksrlilpr.......................
E3LSC8_CAERE/1-104                   .................MSNFYQT-RVIHSVESPMFFDRFPI..KLLVIVVQVVTLLLNIG.YMSQ....PS....LERGV.FIF....EMCINLFLVASIVAFLADYELLMHIHYWAVCVGTI...IPLIFW-----------....----.......----------.--...------.----...----------.------.------.--------------------------glavkdlf.......................
#=GC seq_cons                        ............................p..csPhhhshhPl..KhlVlshQhlhllhQIh.hlht.....s.....pph..llh....plhhllhhuhohsuFLhEpKhlMphHhahshlhhh...lPlshhhhhhhhhhhph....hhss........p...hpshh.hh...hsshlh.hhsh...lhYlhhChtL.lcslp..ps..hP..ht......................................................
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