#=GF ID   DUF5378
#=GF AC   PF17349.3
#=GF DE   Family of unknown function (DUF5378)
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   PRODOM:PD024151 
#=GF GA   25.70 25.70;
#=GF TC   77.70 77.60;
#=GF NC   22.60 21.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR035319;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This is a family of unknown function which is found in
#=GF CC   Mycoplasmataceae.Family members are predicted to contain 7
#=GF CC   trans-membrane regions
#=GF SQ   10
#=GS Q7NC36_MYCGA/9-289       AC Q7NC36.1
#=GS Q8EVY2_MYCPE/10-281      AC Q8EVY2.1
#=GS A0A449AZW5_9MOLU/2-224   AC A0A449AZW5.1
#=GS A0A449AW32_9MOLU/9-284   AC A0A449AW32.1
#=GS A0A449B4I5_9MOLU/9-264   AC A0A449B4I5.1
#=GS A0A084U3S3_MYCIO/14-138  AC A0A084U3S3.1
#=GS Y276_MYCPN/10-285        AC P75501.1
#=GS Q9PQ80_UREPA/14-305      AC Q9PQ80.1
#=GS Y135_MYCGE/9-277         AC P47381.1
#=GS A0A084U4L3_MYCIO/1-200   AC A0A084U4L3.1
Q7NC36_MYCGA/9-289                  ...........IIVSLWLLLIIAT.SKFFI.......RFENNYW-FWFFIGGFMFFYMIIGRQI------.-QFLIPG--WNAADYNSP...FAVSIRHSRLLLLDICPFFAIFAGFGLMVTKNKLIIRSAAPIALFGGLINLYGELFR..LANQYTGKLEAYRFIFIGIGNDQLYFILHVMTTTVALMLICWTT...KWTPRDIL.NQYLFIAIYACYVLSSIQ-LDRKITNNANGILIADWY....IG-GEYQSVSKILRV...PFPT...VIPVGVVITM.--VSITLIwamrygvqelnarIIYPSLAKKQTKFDLKYMWKNLKYNYLKRR.................................
Q8EVY2_MYCPE/10-281                 ...........SISLIIVSLTFLF.NFFGK.......RLVNNYW-FWAIPSLLFLIYFIVFRFYGAWRDL.NQFLQTNSIWLGNELN--...YEDSIIVSKALLLDMCPFVAIALPVSLILDKTRRIANAISPFAILGAGITI--PFIA..YSDPEAAI--SFKYFFVG-GFLPIYFFMHLYLLTYGVMVFSNSR...NRKWIHLL.DCHIFAAIFFGYV-CFVS-FTTKTVWNVTGINANDWE....SSLGEYNMVSQIFNL...PFPS...VMVISFLLAY.-IFVVSIV............sINIYWKKKHQKDFKVIKLKYLKNSKNLKSK.................................
A0A449AZW5_9MOLU/2-224              qlgdlfkhrtp-------------.-----.......---------------------------------.------E-NWQGT-YNE-...-YYSYVLGKSLFLDLCPFFTFALLFTMIFDKTKYASFVISPFCIFASILVI--PFVP..MTEKGATF--SFKYIFIGSDVFRLYYFMHLFLLVFGVLAYKNYSlkgKKLLNVWL.DLQLVAIIFFSYVIIMS--YALDIDQNTTGISRKDWE....KG-GSFYAIHKNLKV...PHPF...EAVIFYLLSY.-LVINSLL............lIKY-----YINNYSFKE-------------wvkfklkrnqqla....................
A0A449AW32_9MOLU/9-284              ..........f-ITFFTAATMLII.NKKFK.......KYLDKYW-VRVTAGLVFLTYIVLFRFVGNWSEIaNITAHKMPGWWHETFH-D...Y-RSYVLSRSLFLDLCPFFTFALLLTMIFDRSKYSSFIVSPFCLFASAIVI--PFV-..-PATEKNFVFSLKYLLIATKEFRLYFFMHWFMFNFGCLAFVNYSl.eNVSYKRIFrDIQITLLVFASYIIIISYIF--NIDKNTTGLSRKDWE....KG-GSFYAISKGLRV...PHPY...QAVLFYIFSI.AWINFIPL.............VKYDLQNEIIIGKFIQKIKSK---------mqqwkrsla........................
A0A449B4I5_9MOLU/9-264              ......atfsf-----FILIVLIS.YKFKE.......ILLNHAS--KILIGIFMLAYFSILRWVPNIKDF.INNENP------------...--SSISISRTFLLDLCPAMFVALSLVLVFDFKNKLLPYFSVAAFICGFITYIFVPITesYVVKDSSSLLDYKYLFIGTDANKMYFMMHYQLMLFGFIYFILTP...KFKLITLF.NISTGLFIYMLYV-IFISRL-YNVTQNATGLVEFDWS....-EYGEYSV----LGS...KFGN...NIWLN-SFIY.-IIVFSILc..........llIRISIYPIIFTKKSILLKKEL---------kki..............................
A0A084U3S3_MYCIO/14-138             ...........IVTVLSVTTMILF.HYFVTlkynrvyRVINSYW-FSIVISIIWLIYFIVVRWSGDIKVL.IDQPLSWSQWKSNDY---...YNYSYSISRVFLLDLCPMIGLVLPIFLIVDKTKNMAKILCPFSIIGSIITIF-----..--------------------------------------------...--------.-------------------------------------....---------------...----...----------.--------.............------------------------------f................................
Y276_MYCPN/10-285                   ...........ILTVAGVLVILGF.TPLIR.......KLKIQFYCLQVFAAILFLYVFFGRQIIYIFPDI.YGTAAKAKNAVANV----...PLDSLRLSRIFLLDLCPFFALIGPIF-IFLRQKKVAGVLAIFGFYGAAITLFGELIF..TPLKQEEI---VKFLFVGLENNQVYFMMHFLSFLLSLAVFLWDD...GFSLISFF.YIHVFALAYLSYVALMVNIFKGQITGNTTGILAEDWL....--SGEYKNVAVFLKL...DPKNadlIFGVSFGLSYfAIVLLTVL.............VNIPTFIQLTKDKQMVKLALQLKKAQASV-a................................
Q9PQ80_UREPA/14-305                 ...........CITCIGLANFLIKpIQIKKhnwltwnYFINTKWIINTLISISFLIYFCCLRWAPNIHVF.FINHIEIINVLRDKFSDDidlYEASITISRTFLLDWCPCFSVLISCVAIFDKKQIIINHLGFLCFCFGLLTIIGGLI-..-GDEPIRWNRLITYIFIGDKPNPIYFSLHFYLCLFGFYLFVNTRktiKIYWIYII.-IHIILITYIIYVNVMILIF--NIKNNASGFSFGDWY...sPIYAQYGTVAQFLQL...NYRL...NALIMCLFMY.AIFIVGYL.............IRYHLQKIYINKYNIKYSQERNYFAYVKNC.................................
Y135_MYCGE/9-277                    ..........iILIIAGVISVLAF.TPLVR.......KLKIRFYLIQVLAIVLFVYVFFGRQIIYLFPDV.YGQNSQS---------SQ...NLDSLRLSRIFLLDLCPFFAVIAPVF-VFLKQKKISGVLAVFGLFGALVTLFGELIF..TPVNEQDI---VNFIFVGTGNNQIYFMMHFLSLLVSLAIILWDN...CFSLISFF.YIHVFALIYFSYVALMVSVFKGQITGNTTGILASDWT....--NGEYKNVATFLNLsnsDPQL...VFIVGFSLSYvAILLMTLF.............ANIPTFMEMKKDKIFIKKEN----------lirkdle..........................
A0A084U4L3_MYCIO/1-200              ..........k-------------.-----.......---------------------------------.------------------...---------------------------------NMAKILCPFSIIGSIITI--FFVV..STDKDISG-NFWKYIFIGTYPNVLIFLLHYINLLFAVFVLLTSK...QFTKWSMV.SMILFMLIYFGYISIFINFF--GVGFNTTGLSKNDWFnsidSSYSEYGSVYNLLPI...GFPS...APIFWFTLAT.---IVAYL.............FIYI-KNITTKDINKKYNRSK---------rwyseidylniillpieikldkffdkfklkltk
#=GC seq_cons                       ............lshhhlhhhlhh.p.hhc.......+hhspaa.hphhhulhaLhYFhhhRhh..h.sh..tp..p...h.ts.h........sSlplSRshLLDLCPFFulhlslshIFDKpKplutlluPFulhGulITIh..hlh..hsspptsh...hKYlFIGstssplYFhMHahhhlaulhlal.ss...phphhshh.slplhhlIYhuYV.lhlphF.hpIstNsTGlstpDW......t.GEYtsVuphLpl...sas....shllhahluY..lllholL.............lph.hh..hhpchphhhhpp..........h................................
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