GenomeNet

Database: Pfam
Entry: DUF5562
LinkDB: DUF5562
Original site: DUF5562 
#=GF ID   DUF5562
#=GF AC   PF17717.1
#=GF DE   Family of unknown function (DUF5562)
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   cORF:C20orf141
#=GF GA   57.30 57.30;
#=GF TC   59.80 59.10;
#=GF NC   50.90 50.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This is a family of unknown function found in mammals. Family
#=GF CC   members have one or several predicted transmembrane regions.
#=GF SQ   38
#=GS G3H447_CRIGR/1-97       AC G3H447.1
#=GS F7CXI0_MACMU/1-114      AC F7CXI0.1
#=GS E1BII6_BOVIN/1-164      AC E1BII6.1
#=GS M0R5Z9_RAT/1-130        AC M0R5Z9.1
#=GS A0A2K5HPX2_COLAP/1-164  AC A0A2K5HPX2.1
#=GS L5JY78_PTEAL/1-100      AC L5JY78.1
#=GS F6V747_CALJA/1-160      AC F6V747.1
#=GS A0A1U7SXA5_TARSY/1-165  AC A0A1U7SXA5.1
#=GS S7PWU6_MYOBR/1-134      AC S7PWU6.1
#=GS A0A1S3EQ65_DIPOR/1-167  AC A0A1S3EQ65.1
#=GS F7H080_CALJA/1-79       AC F7H080.1
#=GS A0A286ZU92_PIG/1-168    AC A0A286ZU92.1
#=GS G3WYT3_SARHA/17-175     AC G3WYT3.1
#=GS G3UHM2_LOXAF/1-137      AC G3UHM2.1
#=GS H2P1E1_PONAB/1-164      AC H2P1E1.1
#=GS F7HJQ1_MACMU/1-164      AC F7HJQ1.1
#=GS G5B4S2_HETGA/1-128      AC G5B4S2.1
#=GS A0A087WNV0_MOUSE/1-95   AC A0A087WNV0.1
#=GS W5P683_SHEEP/1-164      AC W5P683.1
#=GS I3MUF4_ICTTR/1-131      AC I3MUF4.2
#=GS F1Q3F7_CANLF/1-167      AC F1Q3F7.2
#=GS A0A1U7Q9G5_MESAU/1-130  AC A0A1U7Q9G5.1
#=GS L8YCJ7_TUPCH/1-168      AC L8YCJ7.1
#=GS Q6ZPB1_HUMAN/1-116      AC Q6ZPB1.1
#=GS H2QJU6_PANTR/1-164      AC H2QJU6.1
#=GS G3S893_GORGO/1-165      AC G3S893.2
#=GS F7H078_CALJA/1-116      AC F7H078.1
#=GS G1SST5_RABIT/137-249    AC G1SST5.2
#=GS CT141_HUMAN/1-164       AC Q9NUB4.1
#=GS Q9DA59_MOUSE/1-130      AC Q9DA59.1
#=GS G1LXG2_AILME/1-131      AC G1LXG2.1
#=GS A0A096NV85_PAPAN/1-164  AC A0A096NV85.1
#=GS G1RCU9_NOMLE/1-164      AC G1RCU9.2
#=GS A0A1A6GKK4_NEOLE/1-132  AC A0A1A6GKK4.1
#=GS L5M865_MYODS/1-100      AC L5M865.1
#=GS A0A1S3ASA3_ERIEU/1-163  AC A0A1S3ASA3.1
#=GS A0A2K5LKE7_CERAT/1-164  AC A0A2K5LKE7.1
#=GS A0A2I2UI56_FELCA/1-166  AC A0A2I2UI56.1
G3H447_CRIGR/1-97                  ..........m------------------------------------CVPWDFSQAQLLDSIL.GLGALGVTIGTVFSKAGLA..-LLLLLLASFLAFDLLH.GST.GPILPRHRL..LPMGQSQGAGEE--------------.------------.----------------------------ilgisraapaaglalstgapa.............
F7CXI0_MACMU/1-114                 ...........MTRLCLPRPEALEDPIPVPPRGLGAGEGLGSPVHPRVSSWGPNWAQLLDSVL.GLGALGLTIRAVFSTTGPA..--LLLLLVSFLAFDLLH.RCT.SRDA-----..--------------------------.------------.----------------------------aaasgdryhrgwrgatagsal.............
E1BII6_BOVIN/1-164                 ...........MTHLCLPRPEAAVSPTPGPPRGMGAGEGSASPVGPCVSPWGPSWAQVLDSVL.GLGALGLTIWAIFSTTGPA..LLLLLLLVSFLAFDMLH.RPA.GPTWSQHTH..LTRGQSQGAGEGPEQQEAP--PAVAV.AGRLSLQEALLL.LCLGAGLLLGARGVPLTLLALAFCLHPW..................................
M0R5Z9_RAT/1-130                   ..........m------------------------------------CVPWDFSQAQLLDSIL.GLGALGVTIRTVFSTAGLA..-LLLLLLSSFLVFDLLR.GST.GPNLPRHRL..LPTGQSQGAGEGPGQQAAPLSPTGRV.SGLLRLQDALLL.LFLGLSLLLGGSGIPLAMLGLAFCIHPW..................................
A0A2K5HPX2_COLAP/1-164             ...........MTRLCLPRPEALEDPIPVPPRGLGAGEGSGTPVHPRVSSWGPNWAQLLDSVL.GLGALGLTIRAVFSTTGPA..--LLLLLVSFLTFDLLH.RPT.GHTLPQHKL..LTRGQSQGAGEGPGQQEALLLQMGRV.SGQLSLQDALLL.LLMGLGPLLRACSMPLTLLGLAFCLHPW..................................
L5JY78_PTEAL/1-100                 ..........m----------------------------------------------------.---------------AGLA..FLLLLLLVSFLAFDLLH.RPA.SPTRPQHTL..LTGGQSQGAGEGPRQQAALLLPMVAA.TGQLRLQEALLL.LLLGLGLLLGARGMPLALLGLAFCLHPW..................................
F6V747_CALJA/1-160                 ...........MTQLCLPRPKALADLIPVPPRGLDAGEGSCHPVH---VPWGSSWAQLLDSVLyGLGALGMT-SAVFSH-WPA..LLLLLLLKEYQ--EVLG.CSS.DDSRAQHKL..LTRGQSQGAGEGPGQQEALLLQMGAV.SGQLHLQDVLLL.LLLGLGLLLRAYGMPLTLLGLAFCLHPW..................................
A0A1U7SXA5_TARSY/1-165             ...........MSLLCLLRPKASADLIPVSLRGLGAGEGLGSPVPPCVTLMDSSWVQILDSVL.GLMALGLMIQAVFSMAGLA..LLLLLLLVSFLAFDLLH.RPT.GPTLLQHKL..VTRSRSQGAGEGLRRREAVFLPAGTV.TGQLRHQDALLL.LLMALGLLLGARGVPLALLGLTFCL---ll................................
S7PWU6_MYOBR/1-134                 ..........m---------------------------------GPCVFFWGPSPAQLLDSVL.GLGALGLTVRAVFSTAGPA..LLLLLLLVSFLAFDLLH.RPT.APTRPQHTL..LTGGQSQGAGEGPRQQEALLLQTVAI.TGRLSLQEALLL.LLLGLELLLGARGMPLALLGLAFCLYPW..................................
A0A1S3EQ65_DIPOR/1-167             ...........MTLFCLPRPKLLADPIPSPSRGLGAGEGSSWPVCSCASYWDPSWAQLLDSVL.GLGALGLTVGAIFSMTGPA..LLLLLLLISFLTFDLLH.RPTtSPTLPGHRL..LPRGQGQGAGEGPEQEVAPFFPTEAV.PRQLSLQDALLL.LLLSLGLLLGVRGMPLALLGLAFCLHPW..................................
F7H080_CALJA/1-79                  ...........MTQLCLPRPKALADLIPVPPRGLDAGEGSCHPVH---VPWGSSWAQLLDSVLyGLGALGMTSSSLFTLASPT..-----------------.---.---------..--------------------------.------------.----------------------------aaaiaksmin........................
A0A286ZU92_PIG/1-168               ...........MTQLCSSRPKGPAYSIPGLPRGLGAGEGSGSPVGPCVSPGGPSPAQLLDSVL.GLGALGLTIWAVFSTTGPA.sLLLLLLLVSFLAFDLLH.RPA.GPTWPQHTHprLTGGQSQGAGEGPGQVEALLLPTVG-.TGQLALQEALLM.LLLGLGLLLGARGMPLTLLALAFCLHPW..................................
G3WYT3_SARHA/17-175                grgcapgipvn-----------TDRMGPAGGRSLEAGEGPEL-LEGHGAPLRSS-LTFLDGAL.GLGILGLGARLVLALAGPAmmLLLLFLMLSFLTFDLLH.GPQ.DLPLPQRPT..FRPLGPGGGGEGPRLQEPLLPPVL--.-SQ--ILDGF-L.LFTGLGLIFGAL-MPFSIFSLIVSL---qal...............................
G3UHM2_LOXAF/1-137                 ........gtw--------------------------------MGPSVFLWGPSLAHLLDSAL.GLVAVGLAIRAVLFTAVPA..LLLLLLLVNFLAFDLLH.GPT.APTLLQHRP..LAGGPSQGAGEGPGQQGALLLTPVAV.IRQVSLQDALLL.LLLGLGLLLGAQGMPLALLGLAFCLHPW..................................
H2P1E1_PONAB/1-164                 ...........MSRLCLPRPEALEDPFPVPPRGLGAGEGSGSPVRPHVSPWGPSWAQLLDSVL.WLGALGLTIRAVFSTTGPA..--LLLLLVSFLAFDLLH.RPA.GRTLPQRKL..LTRGQSQGAGEGPGQQEALLLQMGTV.SGQLSLQDALLL.LLMGLGPLLTACGMPWTLLGLAFCLHPW..................................
F7HJQ1_MACMU/1-164                 ...........MTRLCLPRPEALEDPIPVPPRGLGAGEGLGSPVHPRVSSWGPNWAQLLDSVL.GLGALGLTIRAVFSTTGPA..--LLLLLVSFLAFDLLH.RPA.GRTLPQHKL..LTRGQSQGAGEGPGQQEALLLQMGRV.SGQLSLQDALLL.LLMGLGPLLRACGMPLTLLGLAFCLHPW..................................
G5B4S2_HETGA/1-128                 ...........--------------------------------------PWDPSQAQLLDSIL.GLGAPGLTTGAVFTMSGAV..LLLLLLLVSFLAFDLLH.RPA.SPTLLQHRL..LTRGQNQGAGKGPGQQAAPLFPTGVI.PGQPSLQDALLL.LLFGLGLLLGAHGIILALLGLVFCLHPW..................................
A0A087WNV0_MOUSE/1-95              .........mc-------------------------------------PPWDFSQAQLLDSIL.GLGALGVTIRTIFSTAGLA..-LLLLLLTSFLVFDLLYgCTS.RDAAA----..--------------------------.------------.----------------------------tsgvgyhrgwrgapagsalvsldhpsglgalvgm
W5P683_SHEEP/1-164                 ...........MTHLCLPRPEAAVSPTPVPPRGMGAGEGSASPVGPCVSPWGPSWAQVLDSVL.GLGALGLTIRGIFSTTGPA..LLLLLLLVSFLAFDMLH.RPA.GPTWSQHTH..LTRGQSQGAGEGPGHQEAP--PAVAV.TGRLSLQEALLL.LFLGAGLLLGARGVPLALLALAFCLHPW..................................
I3MUF4_ICTTR/1-131                 .........mc-------------------------------------SLWHPSQAQLLDSVL.GLGALGLTIRAIFCSAGPA..LLLLLLLVSFLTFDLLH.RPS.DPTIPQHRL..LTRGQSQGAGEGPGQQVAPLLPTGAI.PGQLSLQDALLL.LGLGLGLLLGARGMPLALLGVAFCLHPW..................................
F1Q3F7_CANLF/1-167                 ...........MTQLCLPRPKGPAYPIPVPPRGLSAGEGSNSPVSPCMSPRGLSPAQLWDSVL.GLGALGLTVRAVFSTAGPVllLLLLLLLVSFLTFDLFH.CPA.GPVQPQHIL..LT-GQSQGAGEGPGLQEAVLLPTVAV.TGQLSPQEALLL.LLLSLGLLLGACSVPLALLGLAFYLHPW..................................
A0A1U7Q9G5_MESAU/1-130             ..........m------------------------------------CVPWDFSQAQLLDSIL.GLGALGVTIGTVYSTAGLA..-LLLLLLVSFLAFDLLH.GPT.GPILTQHRL..LPMGQSQGAGEGPGQQAAPLLPTGIV.SGLLSLQDALFL.LFLGLGLFLGGSGIPLTLLGLAFCLHPW..................................
L8YCJ7_TUPCH/1-168                 ...........MTQLCSPRHKAFANPIPAPPRGLGTGEGAGGAVQPWVFPWDPSRAQFLDSVL.GLGVLGLAIRTIFSVAGPAllSLLVLLLVCFLTFDLLH.RPT.PPAQPQHRL..LATRQSQGAGEGPGQRAALLLPTGTV.TGQPGLRDVMLL.LLMGLGLLLGAHGMAAAPFGLALCLHLW..................................
Q6ZPB1_HUMAN/1-116                 ...........MTRLCLPRPEAREDPIPVPPRGLGAGEGSGSPVRPPVSTWGPSWAQLLDSVL.WLGALGLTIQAVFSTTGPA..--LLLLLVSFLTFDLLH.RCT.RHD------..--------------------------.------------.----------------------------aaaasgdryhrgwrgatagsalvs..........
H2QJU6_PANTR/1-164                 ...........MTRLCLPRPKAREDPIPVPPRGLGAGEGSGSPVRPPVSAWGPSWAQLLDSVL.WLGALGLTIQAVFSTTGPA..--LLLLLVSFLTFDLLH.RPA.GRTLPQRKL..LTRGQSQGAGEGPGQQEALLLQMGTV.SGQLSLQDALLL.LLMGLGPLLRACGMPLTLLGLAFCLHPW..................................
G3S893_GORGO/1-165                 ...........MTLLCLPRPEAREDPIPVPPRGLGAGEGSGSPVRPQVSAWGPSWAQLLDSVL.WLGALGLTIQAVFSMTGPA..--LLLLLVSFLTFDLLH.RPA.GRTLPQRKL..LTRGQSQGAGEGPGQQEALLLQMGTV.SGQLSLQDALLLlLLMGLGPLLRACGMPLTLLGLAFCLHPW..................................
F7H078_CALJA/1-116                 ...........MTQLCLPRPKALADLIPVPPRGLDAGEGSCHPVS----PWGSSWAQLLDSVLyGLGALGMT-SQSFHTGQPL..--LLLLLVSCISKTLLP.RCT.SRD------..--------------------------.------------.----------------------------aaassgdryhrgrrgatagsalvglfht......
G1SST5_RABIT/137-249               ...........MTQLCLPRPKALPAPPPVSPRGLGAGEGPSGAARAHVSSWDPSQARLLDSAL.GLGALGLTIRAIFSMAGLA..-LLLLLLLCFLAFDLLH.RPA.SRSLPQHRR..LSRGQNQGAG----------------.------------.----------------------------llas..............................
CT141_HUMAN/1-164                  ...........MTRLCLPRPEAREDPIPVPPRGLGAGEGSGSPVRPPVSTWGPSWAQLLDSVL.WLGALGLTIQAVFSTTGPA..--LLLLLVSFLTFDLLH.RPA.GHTLPQRKL..LTRGQSQGAGEGPGQQEALLLQMGTV.SGQLSLQDALLL.LLMGLGPLLRACGMPLTLLGLAFCLHPW..................................
Q9DA59_MOUSE/1-130                 .........mc-------------------------------------PPWDFSQAQLLDSIL.GLGALGVTIRTIFSTAGLA..-LLLLLLTSFLVFDLLY.GPT.GANLPRHRL..LPMGQSQGAGEGPGQQAAPLSPTKMA.SGLLSLQDALLL.LFLGLRLFLGGSGIPLAMLGLAFCIHPW..................................
G1LXG2_AILME/1-131                 ...........MTQLCLPRPKALAYPIPVPPRGLGAGEESHSPVGPCMSPWSPSVTQLWDSVL.--GALGLTIRTVFSTAGPA..SLLLLLLVSFLAFDLLH.WCTrHDAAAASGH..RCHRGRRGAATG--------------.------------.----------------------------halvsldhaarlgalvhvpc..............
A0A096NV85_PAPAN/1-164             ...........MTRLCLPRPEALEDPIPVPPRGLGAGEGSGSPVHPRVSSWGPNWAQLLDSVL.GLGALGLTIWAVFSTTGPA..--LLLLLVSFLAFDLLH.RPA.GRTLPQHKL..LTRGQSQGAGEGPGQQEALLLQMGRV.SGQLSLQDALLL.LLMGLGPLLRACGMPLTLLGLAFCLHPW..................................
G1RCU9_NOMLE/1-164                 ...........MTRLCLPRPEAREDPIPVPPRGLGAAEGSDRPVCPRVSPWGPSWAQLLDIVL.GLGTLGLTIRAVFSTTGPA..--LLLFLVSFLAFDLLH.RPA.GGTLPQRKL..LTRGQSQGAGEGPGQHEALLLQMGTV.SGQLSLQDALLL.LLMGLGPLLRACGMPLTLLGLAFCLHPW..................................
A0A1A6GKK4_NEOLE/1-132             ........mrv--------------------------------------LWNFSQAQLLDSIL.GLGALGVTIGRVFSTGGLA..-LLLLLLVSFLAFDLLH.GPT.GPTLPRHTL..LPVGQSQGAGEGPGQQAAPFFPTGIV.SGLLSLQDALFL.LFLGLGLFLGGSEV--------------lgisraapaaglalst..................
L5M865_MYODS/1-100                 ..........m----------------------------------------------------.---------------AGPA..LLLLLLLVSFLAFDLLH.RPT.SPTRPQHTL..LTGGQSQGAGEGPRQQEALLLQTVAI.TGRLSLQEALLL.LLLGLELLLGAQGMPLALLGLAFCLYPW..................................
A0A1S3ASA3_ERIEU/1-163             ...........MTQLCSPRPKALAFPIPVRTEGLGDGEAPGRSVDPCASPWGPRPARILDSIL.GLGALGLTVQAVFFMTGPA..LLLLLLLISFLAFDLLH.RPA.DPNLPQHVI..LTGGQSQGAGEGPGQQEAL-QPTVTI.TRQ--IQDALLL.LLLGLGLLLGVHGLPLALLGLAFCLHPW..................................
A0A2K5LKE7_CERAT/1-164             ...........MTRLCLPRPEALEDPIPVPPRGLGAGEGSGSPVHPRVSSWGPNWAQLLDSVL.GLGALGLTIRAVFSTTGPA..--LLLLLVSFLAFDLLH.RPA.GRTLPQHKL..LTRGQSQGAGEGPGQQEALLLQMGRV.SGQLSIQDALLL.LLMGLGPLLRACGMPLTLLGLAFCLHPW..................................
A0A2I2UI56_FELCA/1-166             ...........MTQLCLPRPKALAYPIPVPPRGLGAGEGSCSPMGPRTSPWGPNLAQLLDSVL.GLGALGLTIRTVFSTAGPA..-LLLLLLVSFLAFDLLH.WPA.DAPGPQHTL..LTGGRSQGAGEGPGQREAVLLPTAAVvPGRLSPHEALLL.LLLGLGLFLGARGVPVALLGLAFCLHPW..................................
#=GC seq_cons                      ...........MT.LC.PRPcuht..hPsssRGLsAGEGsstsVts.sssWuPS.AQLLDSVL.GLGALGLTIpAVFSTsGPA...LLLLLLVSFLuFDLLH.RPs.usohPQHpL..LotGQSQGAGEGPGQQtA.Lh.hstl.oGpLuLQ-ALLL.LhhGLG.LLtApGhPLsLLGLAFCLHPW..................................
//
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