GenomeNet

Database: Pfam
Entry: DUF5647
LinkDB: DUF5647
Original site: DUF5647 
#=GF ID   DUF5647
#=GF AC   PF18882.1
#=GF DE   Family of unknown function (DUF5647)
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   SCOP:160761
#=GF GA   27.00 27.00;
#=GF TC   29.20 28.70;
#=GF NC   26.70 26.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   23574940
#=GF RT   Recurrent structural motifs in non-homologous protein
#=GF RT   structures.
#=GF RA   Johansson MU, Zoete V, Guex N;
#=GF RL   Int J Mol Sci. 2013;14:7795-7814.
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This is a family of unknown function. Family members include the
#=GF CC   hypothetical protein TTHC002 from Thermus thermophilus. Its has
#=GF CC   an alpha-beta-alpha-beta(3) structure and forms a dimer with a
#=GF CC   single beta-sheet, folded in a barrel-like shape [1].
#=GF SQ   21
#=GS A0A0C9PW36_9BACT/6-84   AC A0A0C9PW36.1
#=GS Q5SGN2_THET8/3-81       AC Q5SGN2.1
#=GS Q5SGN2_THET8/3-81       DR PDB; 2DBS B; 4-81;
#=GS Q5SGN2_THET8/3-81       DR PDB; 2DBS A; 7-81;
#=GS A0A0M2UZI6_9BACT/6-84   AC A0A0M2UZI6.1
#=GS A0A2C9CGK2_KUEST/6-85   AC A0A2C9CGK2.1
#=GS A0A286U4B6_9BACT/3-81   AC A0A286U4B6.1
#=GS A0A318CQU5_9DELT/4-82   AC A0A318CQU5.1
#=GS D1C126_SPHTD/4-75       AC D1C126.1
#=GS A0A1E3XCD2_9BACT/5-83   AC A0A1E3XCD2.1
#=GS A0A2C9CKC4_KUEST/7-86   AC A0A2C9CKC4.1
#=GS D6STJ1_9DELT/5-81       AC D6STJ1.1
#=GS A0A081C7E4_9BACT/3-80   AC A0A081C7E4.1
#=GS A0A1V6M1B9_9BACT/6-85   AC A0A1V6M1B9.1
#=GS A0A1V6M3N4_9BACT/5-45   AC A0A1V6M3N4.1
#=GS A0A160T036_9CHLR/9-88   AC A0A160T036.2
#=GS A0A160T445_9CHLR/11-90  AC A0A160T445.2
#=GS Q5SGM4_THET8/5-83       AC Q5SGM4.1
#=GS A0A1E3XE35_9BACT/3-80   AC A0A1E3XE35.1
#=GS A0A1E3XAX9_9BACT/5-83   AC A0A1E3XAX9.1
#=GS A0A0S4L3Y3_9BACT/4-81   AC A0A0S4L3Y3.1
#=GS A0A081BV00_9BACT/3-80   AC A0A081BV00.1
#=GS A0A1C0VUX4_9CYAN/26-92  AC A0A1C0VUX4.1
A0A0C9PW36_9BACT/6-84              .........k-IIKKNLDLLNEFMKYAFEHPEVLDKIPPEAELVILPTNDPDLCAVNKKMADSLVK.KGKKVVVVELEKPK.TVIPKIEL-l....................
Q5SGN2_THET8/3-81                  ..........NPAERLAELDGVLMQYLLE-ADLLRELPPTYRLVLLPLDEPEVAAQALAWAMEAPNpEGWPSVYALFLQGR.PIRLLLL--gk...................
#=GR Q5SGN2_THET8/3-81       SS    ..........XXTTTHHHHHHHHHHHHHT-TT-GGGS-SS-EEEEEETT-HHHHHHHHHHHHSS--SSSS-EEEEEEETTE.EEEEEEE--EE...................
A0A0M2UZI6_9BACT/6-84              .........i-FVERNSMLVKEFDRYIIEHPEFADGIPDNALVVMQIEGDEEFNNWARETARGIAE.KNTPIVYVTITELK.PVRSRIEKL.....................
A0A2C9CGK2_KUEST/6-85              ..........EMIERNIELSAEFSRYLFEHPEVETKIPLDAKVVLLPEFDKELKRFNLQLGKNIEA.DGGRVVYILIKNIRpKVLSRIEK-i....................
A0A286U4B6_9BACT/3-81              .........i-MEKKNTDLIKEFNRYMREHPDIAESIPNNAVIIMQLEGDEGFNKWSNKMAREHME.KDQSVVYIRIKKIK.PLISRIEEL.....................
A0A318CQU5_9DELT/4-82              ........il--ERKHAILVTEFDRYVVEHPEFAVNIPRNAQIVLQVEGDEQYNEWSMQLAERQRE.PDQRVVYVKVKGLK.PAKSRL---lrp..................
D1C126_SPHTD/4-75                  .........t-FVDRNIRLGFQLARDIVDDPSLLDEIPDGATVVLIPDDDAELAAANLRQG-----.--------------.---------iaafraganvylrhmrattar
A0A1E3XCD2_9BACT/5-83              ..........EIVRKNLDLHAEWIRYIFEHPEVLDKIPQGAQLVILPNNDPALAKENNKTIGRLKA.EGLPVVIVHLDLPK.PPRPQIEV-i....................
A0A2C9CKC4_KUEST/7-86              .........d-FFMRNSGLSTEFSKYILDHPEMDELLTEEKVIIFLPEFDPELKKFNLTMAKEIEA.GGGKVTYVKVKQLSpKVQSRLVG-v....................
D6STJ1_9DELT/5-81                  ..........ELFKKNQQLSTEFELYLLEHPEVEEKIPDNAVLVLLPDYDQELASRNMEIAQVQKE.AGQVVVYVRVEKLR.--KSRID--gl...................
A0A081C7E4_9BACT/3-80              .........t-YQKFLTMMTTEFDRYIMEHEEFARSIPQNAMIIFEVRGEEEFNNWHHTLSLKHRE.SDQPVIYIQIQKWR.-VHSLIEEV.....................
A0A1V6M1B9_9BACT/6-85              ..........KMIERNIELSAEFSRYLFEHPEIENTIPINAEIILLPEFDQELKEFNLKIGKNIEA.EGGKVIYIKIINIRpKTLSRIEK-i....................
A0A1V6M3N4_9BACT/5-45              ..........EYAERNIGMTFDFIRQIIDHPEIIDTIPDNAELDFID-------------------.--------------.---------knmp.................
A0A160T036_9CHLR/9-88              ..........EVADKVLELSEQFNQFVFDHPEILDNLPDKAVLVFLDAEDQEFNEANKEMAAASPLpTQSERVYVQMRRHV.RIVEQVEW-e....................
A0A160T445_9CHLR/11-90             ..........NVVERNIALVGQIMQYLLDNPDLFDALPDDFELVVLPEDDPEMRLYNLELLDRYSI.EEKPVVFARTKSQTkKGRVLIR--ps...................
Q5SGM4_THET8/5-83                  .........p-MELRIGRLHGLFVEHLLRDPGLREALPHPFVLVALDPSDPELMAYALEAAKRSAG.EG-PMVYALFQGEElRLIIAPEG-p....................
A0A1E3XE35_9BACT/3-80              ..........NYTNFLAMVSTEFHRYLMENDEYTNKIPVNALVIFQVEGEDDFNNWHKETSLKNRE.SNQPIVYVYVKKWR.-KHSSIEEL.....................
A0A1E3XAX9_9BACT/5-83              ..........EIFTKNLILSTEFDRYILEHPEFAEKIPSDAQVVLLPKDDPELSRVNLDIAERQRE.KGQQVVYIHIGSIA.PQISRLTK-v....................
A0A0S4L3Y3_9BACT/4-81              .........l--ESRNSLLGMEFDRHLREHPEFVDKIPENAQVVLLLEGDEDFNTWSLRVGKEQAT.HDQPLPYVMIKKLA.LAHSRIEEL.....................
A0A081BV00_9BACT/3-80              .........t-YQKFLTMITTEFDRYVMENEEFARNIPQNAMIIFEVRGEKEFNTWHHTLSLKHRE.PDQPVIHIQIQKWR.-IHSLIEEV.....................
A0A1C0VUX4_9CYAN/26-92             qmavanmava----------FDYLNFLLENPNALEEIPDSATVII-PTEDTWVNEQNNQIVAQVQK.SGGTVYYVQ-----.---------klv..................
#=GC SS_cons                       ..........XXTTTHHHHHHHHHHHHHT-TT-GGGS-SS-EEEEEETT-HHHHHHHHHHHHSS--SSSS-EEEEEEETTE.EEEEEEE--EE...................
#=GC seq_cons                      ...........hhc+NhtLssEFsRYlhEHPEhh-pIPpsAhlVhlscsDtEhsphshchutp.tt.pst.VVYlplpphc..hhspl-.......................
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