GenomeNet

Database: Pfam
Entry: ECSCR
LinkDB: ECSCR
Original site: ECSCR 
#=GF ID   ECSCR
#=GF AC   PF15820.6
#=GF DE   Endothelial cell-specific chemotaxis regulator
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Jackhmmer:Q19T08
#=GF GA   27.00 27.00;
#=GF TC   27.50 30.90;
#=GF NC   25.40 25.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   18556573
#=GF RT   ECSM2, an endothelial specific filamin a binding protein that
#=GF RT   mediates chemotaxis.
#=GF RA   Armstrong LJ, Heath VL, Sanderson S, Kaur S, Beesley JF, Herbert
#=GF RA   JM, Legg JA, Poulsom R, Bicknell R;
#=GF RL   Arterioscler Thromb Vasc Biol. 2008;28:1640-1646.
#=GF RN   [2]
#=GF RM   19416853
#=GF RT   Identification of ARIA regulating endothelial apoptosis and
#=GF RT   angiogenesis by modulating proteasomal degradation of cIAP-1 and
#=GF RT   cIAP-2.
#=GF RA   Ikeda K, Nakano R, Uraoka M, Nakagawa Y, Koide M, Katsume A,
#=GF RA   Minamino K, Yamada E, Yamada H, Quertermous T, Matsubara H;
#=GF RL   Proc Natl Acad Sci U S A. 2009;106:8227-8232.
#=GF DR   INTERPRO; IPR026247;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   ECSCR, endothelial cell-specific chemotaxis regulator, is a
#=GF CC   family of proteins found in eukaryotes. It is also known as ARIA
#=GF CC   for apoptosis regulator through modulating IAP expression. It is
#=GF CC   a cell surface protein that regulates endothelial chemotaxis and
#=GF CC   tube formation, and interacts with filamin A. Filamin A anchors
#=GF CC   transmembrane proteins to the actin cytoskeleton becoming a
#=GF CC   scaffold for various signalling proteins. ECSCR is also known to
#=GF CC   interact with and regulate the function of several endothelial
#=GF CC   transmembrane molecules. It has been shown to play a role in
#=GF CC   angiogenesis, a complex process involving the migration,
#=GF CC   proliferation, and lumen formation of blood vessels by
#=GF CC   endothelial cells [1]. ECSCR appears also to regulate
#=GF CC   endothelial apoptosis, probably through modulating proteasomal
#=GF CC   degradation of cIAP-1 and cIAP-2 in endothelial cells [2].
#=GF SQ   146
#=GS A0A3Q7XBV4_URSAR/132-234  AC A0A3Q7XBV4.1
#=GS A0A2K6CYL2_MACNE/101-203  AC A0A2K6CYL2.1
#=GS A0A2Y9PCJ1_DELLE/87-189   AC A0A2Y9PCJ1.1
#=GS A0A498LG61_LABRO/110-210  AC A0A498LG61.1
#=GS A0A3Q1LG62_BOVIN/236-338  AC A0A3Q1LG62.1
#=GS A0A452SQT9_URSAM/112-157  AC A0A452SQT9.1
#=GS A0A2K6UWG4_SAIBB/101-203  AC A0A2K6UWG4.1
#=GS M3X1N0_FELCA/131-233      AC M3X1N0.2
#=GS A0A455BAN9_PHYMC/82-184   AC A0A455BAN9.1
#=GS A0A3M0IW96_HIRRU/120-223  AC A0A3M0IW96.1
#=GS A0A2D0T033_ICTPU/37-135   AC A0A2D0T033.1
#=GS A0A452DRR0_CAPHI/93-189   AC A0A452DRR0.1
#=GS A0A2Y9IKC0_ENHLU/108-210  AC A0A2Y9IKC0.1
#=GS H0ZWL1_TAEGU/86-139       AC H0ZWL1.1
#=GS A0A401RZH9_CHIPU/129-223  AC A0A401RZH9.1
#=GS A0A2R9B144_PANPA/101-203  AC A0A2R9B144.1
#=GS A0A2Y9IK80_ENHLU/70-172   AC A0A2Y9IK80.1
#=GS A0A2K6RLE4_RHIRO/101-203  AC A0A2K6RLE4.1
#=GS A0A226PCT7_COLVI/137-219  AC A0A226PCT7.1
#=GS A0A287BAM3_PIG/77-179     AC A0A287BAM3.1
#=GS L9JUL1_TUPCH/111-181      AC L9JUL1.1
#=GS A0A1U8D7P0_ALLSI/146-251  AC A0A1U8D7P0.1
#=GS A0A1S3L2R3_SALSA/157-253  AC A0A1S3L2R3.1
#=GS K7E312_MONDO/134-236      AC K7E312.1
#=GS A0A494BAU9_MOUSE/110-190  AC A0A494BAU9.1
#=GS A0A3Q7TTA5_VULVU/52-150   AC A0A3Q7TTA5.1
#=GS A0A2K5F548_AOTNA/132-234  AC A0A2K5F548.1
#=GS A0A401NIC0_SCYTO/128-227  AC A0A401NIC0.1
#=GS A0A091CKV7_FUKDA/95-195   AC A0A091CKV7.1
#=GS A0A1U8D4Z5_ALLSI/129-234  AC A0A1U8D4Z5.1
#=GS A0A2K6JPB3_RHIBE/101-203  AC A0A2K6JPB3.1
#=GS A0A455AXW0_PHYMC/99-201   AC A0A455AXW0.1
#=GS A0A0Q3LV18_AMAAE/188-289  AC A0A0Q3LV18.1
#=GS A0A383ZAQ5_BALAS/83-185   AC A0A383ZAQ5.1
#=GS A0A402FF05_9SAUR/69-177   AC A0A402FF05.1
#=GS A0A455AXV6_PHYMC/87-189   AC A0A455AXV6.1
#=GS A0A498NXG2_LABRO/156-256  AC A0A498NXG2.1
#=GS W5Q725_SHEEP/133-235      AC W5Q725.1
#=GS H0VUT2_CAVPO/124-226      AC H0VUT2.2
#=GS A0A383ZBP2_BALAS/82-184   AC A0A383ZBP2.1
#=GS A0A2K6H0A8_PROCO/101-203  AC A0A2K6H0A8.1
#=GS M7BWC6_CHEMY/118-207      AC M7BWC6.1
#=GS A0A455AWK6_PHYMC/83-185   AC A0A455AWK6.1
#=GS A0A1U8CRY6_MESAU/147-249  AC A0A1U8CRY6.1
#=GS A0A3Q7WFX9_URSAR/131-233  AC A0A3Q7WFX9.1
#=GS A0A2U4AGY9_TURTR/139-241  AC A0A2U4AGY9.1
#=GS A0A2K5QEM1_CEBCA/101-203  AC A0A2K5QEM1.1
#=GS A0A2Y9INZ6_ENHLU/107-209  AC A0A2Y9INZ6.1
#=GS K7E7N2_ORNAN/65-169       AC K7E7N2.1
#=GS A0A452J3A0_9SAUR/88-188   AC A0A452J3A0.1
#=GS A0A384C4H5_URSMA/132-234  AC A0A384C4H5.1
#=GS A0A226NCJ4_CALSU/137-217  AC A0A226NCJ4.1
#=GS A0A1S3FIB2_DIPOR/110-212  AC A0A1S3FIB2.1
#=GS G5AZ74_HETGA/129-231      AC G5AZ74.1
#=GS G3USH6_MELGA/1-97         AC G3USH6.1
#=GS A0A2K5F569_AOTNA/100-202  AC A0A2K5F569.1
#=GS I3N472_ICTTR/118-220      AC I3N472.2
#=GS A0A2K5YPM1_MANLE/101-203  AC A0A2K5YPM1.1
#=GS A0A2Y9PH88_DELLE/71-173   AC A0A2Y9PH88.1
#=GS A0A2U4AGI1_TURTR/130-232  AC A0A2U4AGI1.1
#=GS A0A2Y9PPC9_DELLE/99-201   AC A0A2Y9PPC9.1
#=GS A0A1S3W4C6_ERIEU/130-232  AC A0A1S3W4C6.1
#=GS A0A2Y9ISX3_ENHLU/91-193   AC A0A2Y9ISX3.1
#=GS A0A2R8MVA5_CALJA/115-217  AC A0A2R8MVA5.1
#=GS K7EVF1_PONAB/95-159       AC K7EVF1.1
#=GS A0A2Y9ILK0_ENHLU/71-173   AC A0A2Y9ILK0.1
#=GS A0A1S3FH11_DIPOR/84-186   AC A0A1S3FH11.1
#=GS G3U8D7_LOXAF/98-200       AC G3U8D7.1
#=GS F6W6D3_MOUSE/83-156       AC F6W6D3.1
#=GS U3JJY1_FICAL/1-79         AC U3JJY1.1
#=GS A0A383ZB72_BALAS/87-189   AC A0A383ZB72.1
#=GS A0A1S3FGQ8_DIPOR/130-232  AC A0A1S3FGQ8.1
#=GS A0A2Y9PFI6_DELLE/83-185   AC A0A2Y9PFI6.1
#=GS A0A3Q7VRY7_URSAR/156-201  AC A0A3Q7VRY7.1
#=GS J9P6U8_CANLF/86-188       AC J9P6U8.1
#=GS A0A340XR94_LIPVE/99-201   AC A0A340XR94.1
#=GS A0A218UDP7_9PASE/129-239  AC A0A218UDP7.1
#=GS F6RF12_MOUSE/83-160       AC F6RF12.1
#=GS A0A2R8PE49_CALJA/132-234  AC A0A2R8PE49.1
#=GS A0A0D9RKQ9_CHLSB/101-203  AC A0A0D9RKQ9.1
#=GS G3UVV5_MOUSE/131-233      AC G3UVV5.1
#=GS A0A1S3FGR3_DIPOR/64-166   AC A0A1S3FGR3.1
#=GS A0A2Y9PMX0_DELLE/70-172   AC A0A2Y9PMX0.1
#=GS M3YCN1_MUSPF/119-221      AC M3YCN1.1
#=GS A0A455AWX5_PHYMC/70-172   AC A0A455AWX5.1
#=GS A0A3Q7T7M1_VULVU/86-188   AC A0A3Q7T7M1.1
#=GS A0A401RJM7_CHIPU/28-121   AC A0A401RJM7.1
#=GS W5N4A9_LEPOC/249-344      AC W5N4A9.1
#=GS A0A287B4P5_PIG/77-179     AC A0A287B4P5.1
#=GS A0A1A6FWE8_NEOLE/137-239  AC A0A1A6FWE8.1
#=GS A0A1V4JW01_PATFA/152-252  AC A0A1V4JW01.1
#=GS A0A1U7SYA8_TARSY/132-234  AC A0A1U7SYA8.1
#=GS A0A2R8M6E8_CALJA/80-182   AC A0A2R8M6E8.1
#=GS F1RGG9_PIG/71-167         AC F1RGG9.2
#=GS A0A3Q7T7M6_VULVU/69-171   AC A0A3Q7T7M6.1
#=GS A0A383ZBB6_BALAS/66-168   AC A0A383ZBB6.1
#=GS A0A060Y0U3_ONCMY/160-256  AC A0A060Y0U3.1
#=GS L5JVF0_PTEAL/50-152       AC L5JVF0.1
#=GS M0RCJ4_RAT/120-222        AC M0RCJ4.2
#=GS A0A383ZAZ3_BALAS/70-172   AC A0A383ZAZ3.1
#=GS A0A2I0LSR7_COLLI/144-246  AC A0A2I0LSR7.1
#=GS A0A2Y9FY53_TRIMA/84-186   AC A0A2Y9FY53.1
#=GS A0A1U7RMR7_ALLSI/122-227  AC A0A1U7RMR7.1
#=GS A0A3L8RVQ5_CHLGU/118-206  AC A0A3L8RVQ5.1
#=GS A0A3Q1MA10_BOVIN/201-303  AC A0A3Q1MA10.1
#=GS A0A383ZBB1_BALAS/99-201   AC A0A383ZBB1.1
#=GS A0A452DJ86_BOVIN/93-191   AC A0A452DJ86.1
#=GS H0XIW9_OTOGA/101-203      AC H0XIW9.1
#=GS A0A151NR41_ALLMI/74-180   AC A0A151NR41.1
#=GS F1NUH5_CHICK/129-232      AC F1NUH5.2
#=GS A0A151NR00_ALLMI/57-163   AC A0A151NR00.1
#=GS A0A1S3FHJ9_DIPOR/93-195   AC A0A1S3FHJ9.1
#=GS A0A2K5NK98_CERAT/101-203  AC A0A2K5NK98.1
#=GS ECSCR_BOVIN/93-195        AC Q2KIX5.1
#=GS I3MWV9_ICTTR/135-237      AC I3MWV9.2
#=GS ECSCR_HUMAN/101-203       AC Q19T08.1
#=GS ECSCR_MOUSE/110-212       AC Q3TZW0.2
#=GS A0A2R8MRK9_CALJA/101-203  AC A0A2R8MRK9.1
#=GS G1RD79_NOMLE/55-104       AC G1RD79.2
#=GS G3SFD2_GORGO/101-203      AC G3SFD2.2
#=GS A0A2K5HE07_COLAP/101-203  AC A0A2K5HE07.1
#=GS G3U967_LOXAF/93-195       AC G3U967.1
#=GS G1Q611_MYOLU/105-207      AC G1Q611.1
#=GS G3WC87_SARHA/77-180       AC G3WC87.1
#=GS G1U7J5_RABIT/97-201       AC G1U7J5.1
#=GS ECSCR_CANLF/71-173        AC P0C8R9.1
#=GS H2RHT1_PANTR/96-193       AC H2RHT1.2
#=GS A0A091EY12_CORBR/43-101   AC A0A091EY12.1
#=GS K7G2T4_PELSI/54-174       AC K7G2T4.1
#=GS A0A151NQS2_ALLMI/99-204   AC A0A151NQS2.1
#=GS A0A2K5VTV2_MACFA/101-203  AC A0A2K5VTV2.1
#=GS A0A3Q1MIE4_BOVIN/219-321  AC A0A3Q1MIE4.1
#=GS A0A2U4AGG6_TURTR/123-225  AC A0A2U4AGG6.1
#=GS A0A1V4JVZ9_PATFA/142-243  AC A0A1V4JVZ9.1
#=GS G1LXM5_AILME/133-235      AC G1LXM5.1
#=GS K7A467_PANTR/101-203      AC K7A467.1
#=GS E7F0W6_DANRE/125-225      AC E7F0W6.1
#=GS F6QG66_HORSE/145-247      AC F6QG66.2
#=GS A0A455AYU8_PHYMC/66-168   AC A0A455AYU8.1
#=GS H0W6V1_CAVPO/109-211      AC H0W6V1.2
#=GS A0A2U4AGP7_TURTR/127-229  AC A0A2U4AGP7.1
#=GS A0A096N165_PAPAN/119-163  AC A0A096N165.2
#=GS A0A2D0SZP5_ICTPU/6-118    AC A0A2D0SZP5.1
#=GS A0A2U3VRJ9_ODORO/132-234  AC A0A2U3VRJ9.1
#=GS A0A2U3YXS7_LEPWE/132-198  AC A0A2U3YXS7.1
#=GS A0A2K6UWN6_SAIBB/132-234  AC A0A2K6UWN6.1
A0A3Q7XBV4_URSAR/132-234             ..........................SLRTGEDLSILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSAAN...GEKD.SITLISMKNINTNNSKGCPTAEK..................................
A0A2K6CYL2_MACNE/101-203             ..........................SLSMREDATILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCRK.SKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.RITLISMKNINMNNGKQSLSAEK..................................
A0A2Y9PCJ1_DELLE/87-189              .........................n-LRTREDSTILP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPSAEK..................................
A0A498LG61_LABRO/110-210             ....................snisms------EVTATP..SQAP.D.S.G.LTLLAFG..VMSLILILIVVMVVLVTAINLRGRCRN.SKQ.HEG-MKSR.DSVLSDS..NMTST...CEKE.SITLVSVRTINTENNTDSP----qms...............................
A0A3Q1LG62_BOVIN/236-338             .........................s-FRTTADSTVPP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..GSTAN...GEKE.SITLISMKNINMNNSKGCPSAEK..................................
A0A452SQT9_URSAM/112-157             .........................f------------..----.-.-.-.-------..---------------------------.---.--DPQKPG.SSGLSES..CSAAN...GEKD.SITLISMKNINTNNSKGCPTAEK..................................
A0A2K6UWG4_SAIBB/101-203             .........................s-LSTREDVTILP..KPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVAVVSLRFKCRK.SKE.SEDPQKPG.SSGLSES..GSTAN...GEKD.SITLISMKNINMNNGKQSLSAEK..................................
M3X1N0_FELCA/131-233                 ..........................SLRTRDDSTILP..TPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPTAEK..................................
A0A455BAN9_PHYMC/82-184              ..........................SLRTREDSTILP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPAAEK..................................
A0A3M0IW96_HIRRU/120-223             ................tpsssrqlpe-----------P..TPTD.E.KsP.LTVAAFG..VISFVVILIVVVIILVSVVSLRFKCNH.SKD.SEDKQKPG.ASMVSES..CSADT...SQKGnSITLISMKNINTNNSMSYPPSEK..................................
A0A2D0T033_ICTPU/37-135              .................nvtqqtgdg---------AKP..TQTP.D.N.G.LTMLAFG..VMSFILILIIVMVILVTAVNFRGQCAN.TKE.--EGVKNY.VSVISEG..HISNM...GEKE.SIMLVSMRTINTDTD--------tdslri............................
A0A452DRR0_CAPHI/93-189              .........................s-FRMTADSTVPP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIVLVSVVSLRFKCQK.NKE.SEGT-CPD.PQGPL--..---SN...GEKE.SITLISMKNINMNNSKGCPSAEK..................................
A0A2Y9IKC0_ENHLU/108-210             ..........................SLRTKEDLSVLP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGYPTAEK..................................
H0ZWL1_TAEGU/86-139                  .................xxxncpspp------------..-DRR.E.S.P.LTVAAFG..VISFVVILIVVVIILVSVVSLRFKCNH.SKD.SE------.-------..-----...----.-----------------------..................................
A0A401RZH9_CHIPU/129-223             ...................asslqpt----------LT..TSAN.EsS.P.LSVLAFA..VIILILILVIVVVILVCVISLRFKCRG.VQDaSIDSRKAR.NAAPSES..-SQAN...GEKE.SITLVSMRTLST-----------etggp.............................
A0A2R9B144_PANPA/101-203             ..........................SLSMREDATILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVGVVSLRFKCRK.SKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNGKQSLSAEK..................................
A0A2Y9IK80_ENHLU/70-172              ..........................SLRTKEDLSVLP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGYPTAEK..................................
A0A2K6RLE4_RHIRO/101-203             ..........................SLSMREDTTILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCQK.SKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNGKQSLSAEK..................................
A0A226PCT7_COLVI/137-219             ..................qeisvsls----------VP..TPTEyE.S.P.LTVVAFG..VISFIVILVVVVIILVSVVSLRFKCNR.SKD.SEDKQKPG.NSMVSER..CYEAN...N---.-----------------------peqeadt...........................
A0A287BAM3_PIG/77-179                ..........................SLRTREDPTVLP..SPTS.E.T.V.LTVAAFG..VISFIVILLVVVIILVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPSAEK..................................
L9JUL1_TUPCH/111-181                 .................tppqpqkht------------..----.-.-.-.---SGLG..VISFIVILVVVVIILVGVVSLRFKCRK.NKE.SEDPQKPG.SSGLSER..I----...----.-----------------------kkcrnyyeilgv......................
A0A1U8D7P0_ALLSI/146-251             .............aisaentmispsa-----------I..TPTE.K.S.G.LEIVAFG..VIGFIGILVVVVFILVGVVYLRFRCNH.SKD.AEDKQKPE.DPVVSES..CSAAT...NRKNsSVTLISMKNINMNNSLSYPTSEK..................................
A0A1S3L2R3_SALSA/157-253             ......................kgth-------TDIPP..TQSP.D.K.S.LTMLAFG..VMSLILILVIIMVVLVTVVNLKDKCSH.SKE.--EGKKSS.DSVVSES..NVTFS...GEKE.SITLISMKTINTETDTDS-----pqvs..............................
K7E312_MONDO/134-236                 .....................mdlra-----TEKPILP..TPTS.E.T.V.LTVAAFG..VITFIIILVVVVIILVSVVSLRFKCRK.NKE.SEDPQKPE.ICGMFES..-STAI...GEKDtSITLISMKNINSNNNKGSYTEEK..................................
A0A494BAU9_MOUSE/110-190             ..................tkkmtill--------TILP..TPTS.E.S.V.LTVAAFG..VISFIVILVVVVIILVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..-MLGN...LE--.-----------------------qdkl..............................
A0A3Q7TTA5_VULVU/52-150              .......tgnsssseprsssspasag------------..----.-.-.-.----TPG..VISFIVILVVVVIILVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPTAEK..................................
A0A2K5F548_AOTNA/132-234             .........................s-LSTREDVTILP..KPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVAVVSLRFKCRK.SKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNGKQSLSAEK..................................
A0A401NIC0_SCYTO/128-227             .................sasglepst----------AP..AASG.S.S.S.LSVLAFV..VIILILILVIVVVILVSVISVRFKCCDlEDA.SHGTRKAR.NTAPAES..-SQVN...GEKE.SITLVSMRTLST-----------etggqessv.........................
A0A091CKV7_FUKDA/95-195              .....................attms-------LTILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCRK.NKD.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSRGCPSAEK..................................
A0A1U8D4Z5_ALLSI/129-234             .............aisaentmispsa-----------I..TPTE.K.S.G.LEIVAFG..VIGFIGILVVVVFILVGVVYLRFRCNH.SKD.AEDKQKPE.DPVVSES..CSAAT...NRKNsSVTLISMKNINMNNSLSYPTSEK..................................
A0A2K6JPB3_RHIBE/101-203             ..........................SLSMREDATILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCQK.SKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNGKQSLSAEK..................................
A0A455AXW0_PHYMC/99-201              ..........................SLRTREDSTILP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPAAEK..................................
A0A0Q3LV18_AMAAE/188-289             ...................mssgylp----------VP..TPTD.DkS.P.LTVAAFG..VISFIVILIVVVIILVSVVSLRFKCNR.SKD.SEDKQKPG.TSMVSES..CSAGT...SQKDnSITLISMKNINMNNSMSYPPSEK..................................
A0A383ZAQ5_BALAS/83-185              ..........................SLRTREDSTILP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIILVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPSAEK..................................
A0A402FF05_9SAUR/69-177              ........slpitntegflgstppme------------..---E.K.S.A.LTVAALG..VISFIVILVVVVIVLVSIVSLKFRCHY.CKD.MEEKQKPQ.HLEVSYS..CPDAAdpaAAKT.NITLVSMKNLNANNSKGIM----kttv..............................
A0A455AXV6_PHYMC/87-189              ..........................SLRTREDSTILP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPAAEK..................................
A0A498NXG2_LABRO/156-256             ....................snisms------EVTATP..SQAP.D.S.G.LTLLAFG..VMSLILILIVVMVVLVTAINLRGRCRN.SKQ.HEG-MKSR.DSVLSDS..NMTST...CEKE.SITLVSVRTINTENNTDSP----qms...............................
W5Q725_SHEEP/133-235                 .........................s-FRMTADSTVPP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIVLVSVVSLRFKCQK.NKE.SEDPQKPG.SSGLSES..GSTAN...GEKE.SITLISMKNINMNNSKGCPSAEK..................................
H0VUT2_CAVPO/124-226                 ..........................SLRTRGDLTILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVAVVSLRFKCRK.NKD.AEDPQKPG.SSGLSES..CSTAN...GEKH.SITLISMKNINMNNSKACPSAEK..................................
A0A383ZBP2_BALAS/82-184              ..........................SLRTREDSTILP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIILVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPSAEK..................................
A0A2K6H0A8_PROCO/101-203             .........................s-LSAREDLTVLP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRK.SKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLLSMKNINMNNSKGGLSAEK..................................
M7BWC6_CHEMY/118-207                 ...................tgpslpd-----------P..VPTE.EkS.A.LTMAAFG..VISFIVVLVVVVIVLASVVSLRFKCNR.SKD.AEA-----.-------..-----...----.-----------------------lidalrrnacpteensessdfcacsdcmrgkkek
A0A455AWK6_PHYMC/83-185              ..........................SLRTREDSTILP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPAAEK..................................
A0A1U8CRY6_MESAU/147-249             .......................slw---TGEEVTILP..SPTS.E.S.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSAAS...GEKD.SITLLSMKSINMDNSKGCPSAEK..................................
A0A3Q7WFX9_URSAR/131-233             ..........................SLRTGEDLSILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSAAN...GEKD.SITLISMKNINTNNSKGCPTAEK..................................
A0A2U4AGY9_TURTR/139-241             .........................n-LRTREDSTVLP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPSAEK..................................
A0A2K5QEM1_CEBCA/101-203             .........................s-LSTKEDVTILP..KPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVAVVSLRFKCRK.SKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNGKQSLSAEK..................................
A0A2Y9INZ6_ENHLU/107-209             ..........................SLRTKEDLSVLP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGYPTAEK..................................
K7E7N2_ORNAN/65-169                  ..............alvrtqagpias----------QP..SPTE.K.S.V.LTVAAFG..VISFIVILVIVVIVLVSVVSLRFRCNR.NKE.SENAQKPG.ISGVSES..CSPAN...GEKE.RITLISMKNINTNNSKGCSTAEK..................................
A0A452J3A0_9SAUR/88-188              ..................stgpslpd-----------P..TPTE.EkS.A.LTVAAFG..VISFIVILVVVVIVLASVVSLRFKCNR.SKD.AEDKQKPG.SSMVSES..SCSPA...TAKD.SITLISMKNLSMNNSTSYPSSEK..................................
A0A384C4H5_URSMA/132-234             ..........................SLRTGEDLSILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSAAN...GEKD.SITLISMKNINTNNSKGCPTAEK..................................
A0A226NCJ4_CALSU/137-217             ..................qeisvsls----------VP..TPTEyE.S.P.LTVVAFG..VISFIVILVVVVIILVSVVSLRFKCNR.SKD.SEDKQKPG.NSMVSER..CYEAN...----.-----------------------npelea............................
A0A1S3FIB2_DIPOR/110-212             ..........................SLRTRGNLTIVP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCRK.NKE.PEDPQKPG.NSGVSES..CSTAN...GEKD.SITLISVKNINMNNSKGCPSAEK..................................
G5AZ74_HETGA/129-231                 ..........................SLRTREDLTILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCRK.NKD.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKACPSAEK..................................
G3USH6_MELGA/1-97                    ..........................----------MP..TPTEyE.S.P.LTVVAFG..VISFIVILVVVVIILVSVVSLRFKCNR.SKD.SEDKQKPG.SSMVSESdsCSAGT...SEKDnSITLISMKNINMNNSMTYPPSEK..................................
A0A2K5F569_AOTNA/100-202             .........................s-LSTREDVTILP..KPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVAVVSLRFKCRK.SKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNGKQSLSAEK..................................
I3N472_ICTTR/118-220                 .......................nss---MMEDLTILP..SPTL.A.T.V.LTVAAFG..VISFIVILVVVVIILVAVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPSAEK..................................
A0A2K5YPM1_MANLE/101-203             ..........................SLSMREDATILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCRK.SKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.CITLISMKNINMNNGKQSLSAEK..................................
A0A2Y9PH88_DELLE/71-173              .........................n-LRTREDSTILP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPSAEK..................................
A0A2U4AGI1_TURTR/130-232             .........................n-LRTREDSTVLP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPSAEK..................................
A0A2Y9PPC9_DELLE/99-201              .........................n-LRTREDSTILP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPSAEK..................................
A0A1S3W4C6_ERIEU/130-232             .....................mslrt-----RDLVIQP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.NSGLSES..CSTAN...GEKD.RITLISMKNINTNNSKGCPSAEK..................................
A0A2Y9ISX3_ENHLU/91-193              ..........................SLRTKEDLSVLP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGYPTAEK..................................
A0A2R8MVA5_CALJA/115-217             .........................s-LSTREDVTILP..KPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVAVVSLRFKCRK.SKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNGKQSLSAEK..................................
K7EVF1_PONAB/95-159                  ..........................SLSMREDVTILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCRK.SKE.SEG-----.-------..-----...----.-----------------------vcpalg............................
A0A2Y9ILK0_ENHLU/71-173              ..........................SLRTKEDLSVLP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGYPTAEK..................................
A0A1S3FH11_DIPOR/84-186              ..........................SLRTRGNLTIVP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCRK.NKE.PEDPQKPG.NSGVSES..CSTAN...GEKD.SITLISVKNINMNNSKGCPSAEK..................................
G3U8D7_LOXAF/98-200                  .........................s-LRTGEYLTILP..SPTS.E.S.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGISES..CSTAN...GEKD.SITLISMKNINTNNSKRWSSAEK..................................
F6W6D3_MOUSE/83-156                  ..................tkkmtill--------TILP..TPTS.E.S.V.LTVAAFG..VISFIVILVVVVIILVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSER..-----...----.-----------------------vfw...............................
U3JJY1_FICAL/1-79                    ..........................------------..----.-.-.-.------G..VISFVVILIVVVIILVSVVSLRFKCNH.SKD.SEDKQKPG.SSMVSES..CSADT...SQKGnSITLISMKNINTNNSMSYPPSEK..................................
A0A383ZB72_BALAS/87-189              ..........................SLRTREDSTILP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIILVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPSAEK..................................
A0A1S3FGQ8_DIPOR/130-232             ..........................SLRTRGNLTIVP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCRK.NKE.PEDPQKPG.NSGVSES..CSTAN...GEKD.SITLISVKNINMNNSKGCPSAEK..................................
A0A2Y9PFI6_DELLE/83-185              .........................n-LRTREDSTILP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPSAEK..................................
A0A3Q7VRY7_URSAR/156-201             .........................f------------..----.-.-.-.-------..---------------------------.---.--DPQKPG.SSGLSES..CSAAN...GEKD.SITLISMKNINTNNSKGCPTAEK..................................
J9P6U8_CANLF/86-188                  ..........................SLRIREDSTILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPTAEK..................................
A0A340XR94_LIPVE/99-201              ..........................SLRTREDSTILP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPSAEK..................................
A0A218UDP7_9PASE/129-239             .........asepitptpnsssqlpe-----------P..TPTD.E.KsP.LTVAAFG..VISFVVILIVVVIILVSVVSLRFKCNH.SKD.SEDKQKPG.TSMVSES..CSADT...SQKGnSITLISMKNINTNNSMNYPPSEK..................................
F6RF12_MOUSE/83-160                  ..................tkkmtill--------TILP..TPTS.E.S.V.LTVAAFG..VISFIVILVVVVIILVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSER..-----...----.-----------------------ffksdle...........................
A0A2R8PE49_CALJA/132-234             .........................s-LSTREDVTILP..KPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVAVVSLRFKCRK.SKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNGKQSLSAEK..................................
A0A0D9RKQ9_CHLSB/101-203             ..........................SLSMREDATILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCRK.SKE.SEDPQKPG.SSGLPES..CSTAN...GEKD.RITLISMKNINMNNGKQSLSAEK..................................
G3UVV5_MOUSE/131-233                 ..................tkkmtill--------TILP..TPTS.E.S.V.LTVAAFG..VISFIVILVVVVIILVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMRNINVNNSKGSMSAEK..................................
A0A1S3FGR3_DIPOR/64-166              ..........................SLRTRGNLTIVP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCRK.NKE.PEDPQKPG.NSGVSES..CSTAN...GEKD.SITLISVKNINMNNSKGCPSAEK..................................
A0A2Y9PMX0_DELLE/70-172              .........................n-LRTREDSTILP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPSAEK..................................
M3YCN1_MUSPF/119-221                 ..........................SLRTKEDLSVLP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGYPTAEK..................................
A0A455AWX5_PHYMC/70-172              ..........................SLRTREDSTILP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPAAEK..................................
A0A3Q7T7M1_VULVU/86-188              ..........................SLRIREDSTILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPTAEK..................................
A0A401RJM7_CHIPU/28-121              pppsswnessssrapfgssstaknll------------..----.-.-.-.-------..---LVLLLVIAMLVLISLIVLRFKCRN.YRK.----QKRE.AKDITSH..QSTA-...-DRD.QVTLISVRMTDTDAGEGSF----wkdn..............................
W5N4A9_LEPOC/249-344                 .............rgqdstsavkeps------------..----.-.S.S.LSMLAFG..VMSFILILIIVMVVLVTAVNLRGRCRG.SRD.--EGKKSG.DSVVSES..NITVN...GEKE.SITLVSMKTINTETDTDS-----pris..............................
A0A287B4P5_PIG/77-179                ..........................SLRTREDPTVLP..SPTS.E.T.V.LTVAAFG..VISFIVILLVVVIILVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPSAEK..................................
A0A1A6FWE8_NEOLE/137-239             ..........................SLRTREDVTILP..SPTS.E.S.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGISES..CSTAN...GEKD.SITLISMKNINMNNSKGCTSAEK..................................
A0A1V4JW01_PATFA/152-252             ....................lsgylt----------TP..TPTD.E.K.SpLTVAAFG..VISFIVILIVVVIILVSVVSLRFKCNR.SKD.SEDKQKPG.TSVVSES..CSAGT...SQKEnSITLISMKNINTNNSRSYPPSEK..................................
A0A1U7SYA8_TARSY/132-234             .........................s-LSTREALTILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCQK.NKE.AEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGHLSAEK..................................
A0A2R8M6E8_CALJA/80-182              .........................s-LSTREDVTILP..KPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVAVVSLRFKCRK.SKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNGKQSLSAEK..................................
F1RGG9_PIG/71-167                    ..........................SLRTREDPTVLP..SPTS.E.T.V.LTVAAFG..VISFIVILLVVVIILVSVVSLRFKCRK.NKE.SEGT-RPD.P-----R..CSTAN...GEKD.SITLISMKNINMNNSKGCPSAEK..................................
A0A3Q7T7M6_VULVU/69-171              ..........................SLRIREDSTILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPTAEK..................................
A0A383ZBB6_BALAS/66-168              ..........................SLRTREDSTILP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIILVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPSAEK..................................
A0A060Y0U3_ONCMY/160-256             ......................kgth-------TDIPP..TQSP.G.K.S.LTMLAFG..VMTLILILIIIMVVLVTVVNLKDKCSN.SKE.--EGKKSS.DSVVSES..NVTFS...GEKE.SITLISMKTINTETDTDS-----pqvs..............................
L5JVF0_PTEAL/50-152                  ..........................SLRTREDSTILA..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPSAEK..................................
M0RCJ4_RAT/120-222                   .....................sslrt-----KEGTILP..TPTS.E.S.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINTNNSKGCTSAEK..................................
A0A383ZAZ3_BALAS/70-172              ..........................SLRTREDSTILP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIILVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPSAEK..................................
A0A2I0LSR7_COLLI/144-246             .................tvpsgylpt-----------P..TPTD.DkS.P.LTVAAFG..VISFIVILIVVVIILVSVVSLRFKCNR.SKD.SEDKQKPG.TSVVSES..CSAGT...SQKEnSITLISMKNINTNNSRSYPPSEK..................................
A0A2Y9FY53_TRIMA/84-186              ....................slrtgg------YLTILP..SPTS.E.S.V.LTVAAFG..VISFIVILVVVVIILVSVVSLRFKCRK.NKE.SEDPQKPG.SSGISES..CSTAN...GEKD.SITLISMKNINTNNSKECSSAEK..................................
A0A1U7RMR7_ALLSI/122-227             .............aisaentmispsa-----------I..TPTE.K.S.G.LEIVAFG..VIGFIGILVVVVFILVGVVYLRFRCNH.SKD.AEDKQKPE.DPVVSES..CSAAT...NRKNsSVTLISMKNINMNNSLSYPTSEK..................................
A0A3L8RVQ5_CHLGU/118-206             .........asepitptpnsssqlpe-----------P..TPTD.E.KsP.LTVAAFG..VISFVIILIVVVIILVSVVSLRFKCNH.SKD.SEDKQKPG.TSMVSER..CYEAK...----.-----------------------stelea............................
A0A3Q1MA10_BOVIN/201-303             .........................s-FRTTADSTVPP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..GSTAN...GEKE.SITLISMKNINMNNSKGCPSAEK..................................
A0A383ZBB1_BALAS/99-201              ..........................SLRTREDSTILP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIILVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPSAEK..................................
A0A452DJ86_BOVIN/93-191              .........................s-FRTTADSTVPP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIVLVSVVSLRFKCRK.NKE.SEGT-CPD.SQGP---..GSTAN...GEKE.SITLISMKNINMNNSKGCPSAEK..................................
H0XIW9_OTOGA/101-203                 .......................sps---ARDDLGILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAG...REKD.SITLISMKNINMNSSKGCNSAEK..................................
A0A151NR41_ALLMI/74-180              ............eaisaentmispsa-----------I..TPTE.K.S.G.LEIVAFG..VIGFIGILVVVVFILVGVVYLRFRCNH.SKD.AEDKQKPE.DPVVSES..CSAAT...NRKNsSVTLISMKNINMNNSLSYPTSEK..................................
F1NUH5_CHICK/129-232                 .................aleisvslp----------VP..TPTEyE.S.P.LTVVAFG..VISFIVILVVIVIILVSVVSLRFKCNR.SKD.SEDKQKPG.SSMVSEG..CSAGT...SEKDnSITLISMKNINMNNSMTYPPSEK..................................
A0A151NR00_ALLMI/57-163              ............eaisaentmispsa-----------I..TPTE.K.S.G.LEIVAFG..VIGFIGILVVVVFILVGVVYLRFRCNH.SKD.AEDKQKPE.DPVVSES..CSAAT...NRKNsSVTLISMKNINMNNSLSYPTSEK..................................
A0A1S3FHJ9_DIPOR/93-195              ..........................SLRTRGNLTIVP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCRK.NKE.PEDPQKPG.NSGVSES..CSTAN...GEKD.SITLISVKNINMNNSKGCPSAEK..................................
A0A2K5NK98_CERAT/101-203             ..........................SLSMREDATILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCRK.SKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.RITLISMKNINMNNGKQSLSAEK..................................
ECSCR_BOVIN/93-195                   .........................s-FRTTADSTVPP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..GSTAN...GEKE.SITLISMKNINMNNSKGCPSAEK..................................
I3MWV9_ICTTR/135-237                 .......................nss---MMEDLTILP..SPTL.A.T.V.LTVAAFG..VISFIVILVVVVIILVAVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPSAEK..................................
ECSCR_HUMAN/101-203                  ..........................SLSMREDATILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVGVVSLRFKCRK.SKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNGKQSLSAEK..................................
ECSCR_MOUSE/110-212                  ..................tkkmtill--------TILP..TPTS.E.S.V.LTVAAFG..VISFIVILVVVVIILVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMRNINVNNSKGSMSAEK..................................
A0A2R8MRK9_CALJA/101-203             .........................s-LSTREDVTILP..KPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVAVVSLRFKCRK.SKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNGKQSLSAEK..................................
G1RD79_NOMLE/55-104                  .....................ipssd------------..----.-.-.-.-------..---------------------------.---.---ANSPShLSSTGTP..CSTAN...GEKD.SITLISMKNINMNNGKQSLSAEK..................................
G3SFD2_GORGO/101-203                 ..........................SLSMREDATILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVGVVSLRFKCRK.SKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNGKQSLSAEK..................................
A0A2K5HE07_COLAP/101-203             ..........................SLSMREDATILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCRK.SKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNGKQSLSAEK..................................
G3U967_LOXAF/93-195                  .........................s-LRTGEYLTILP..SPTS.E.S.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGISES..CSTAN...GEKD.SITLISMKNINTNNSKRWSSAEK..................................
G1Q611_MYOLU/105-207                 ........................sp--RTREDPTILP..SPMS.E.Q.V.LTVAAFG..VISFIVILVVVVIILVSVVSLRFKCQK.NKE.SEDPQKPG.SSGLSES..CSAAN...GEKD.SITLISMKNINMNNSKGCRSAEK..................................
G3WC87_SARHA/77-180                  ......................mdlr----TTEKPVLP..TPTS.E.T.V.LTVAAFG..VITFIIILVVVVIILVSVVSLRFKCQK.NKE.SEDPQKPD.SCGMSES..SSTAN...REKDtSITLISMKNINSNNNKGCFTEEK..................................
G1U7J5_RABIT/97-201                  .........................t-LRTRDDLSILP..SPTS.E.T.V.LTVAAFGsgVISFIVILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGVSES..CSTAN...GEKD.SITLISMKNINTNNSKGCPSAEK..................................
ECSCR_CANLF/71-173                   ..........................SLRIREDSTILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPTAEK..................................
H2RHT1_PANTR/96-193                  ..........................SLSMREDATILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVGVVSLRFKCRK.SKE.SEGA--PP.S---SPS..CSTAN...GEKD.SITLISMKNINMNNGKQSLSAEK..................................
A0A091EY12_CORBR/43-101              ...............ptpnhsshlpq-----------P..SPTD.E.KsP.LTVAAFG..VISFVVILIVVVIILVSVVSLRFKCNH.SKD.P-------.-------..-----...----.-----------------------e.................................
K7G2T4_PELSI/54-174                  .....kptaggaseqlpstastsdrs------TSPALPdpAPTE.EkS.A.LTMAAFG..VISFIVILVVVVIILVSVVSLRFKCTR.AKD.TEDKQKPG.SSVVSES..CSAAT...AKKS.SVTLISMKDLSMNNSATYPTSEK..................................
A0A151NQS2_ALLMI/99-204              .............aisaentmispsa-----------I..TPTE.K.S.G.LEIVAFG..VIGFIGILVVVVFILVGVVYLRFRCNH.SKD.AEDKQKPE.DPVVSES..CSAAT...NRKNsSVTLISMKNINMNNSLSYPTSEK..................................
A0A2K5VTV2_MACFA/101-203             ..........................SLSMREDATILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCRK.SKG.SEDPQKPG.SSGLSES..CSTAN...GEKD.RITLISMKNINMNNGKQSLSAEK..................................
A0A3Q1MIE4_BOVIN/219-321             .........................s-FRTTADSTVPP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..GSTAN...GEKE.SITLISMKNINMNNSKGCPSAEK..................................
A0A2U4AGG6_TURTR/123-225             .........................n-LRTREDSTVLP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPSAEK..................................
A0A1V4JVZ9_PATFA/142-243             ...................vlsgylt----------TP..TPTD.E.K.SpLTVAAFG..VISFIVILIVVVIILVSVVSLRFKCNR.SKD.SEDKQKPG.TSVVSES..CSAGT...SQKEnSITLISMKNINTNNSRSYPPSEK..................................
G1LXM5_AILME/133-235                 .........................n-LRTGEDLSVLP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSAAN...GEKD.SITLISMKNINMNNSKGCPTAEK..................................
K7A467_PANTR/101-203                 ..........................SLSMREDATILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVGVVSLRFKCRK.SKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNGKQSLSAEK..................................
E7F0W6_DANRE/125-225                 ....................snisms------EATATP..SPA-.E.S.R.LTLLAFG..VMSLILILIVVMVILVAAVNLKGRCCR.NTQ.QHESIKNR.DSLVSDS..NLTSN...GEKE.NITLVSVRTINTEYNADSP----qis...............................
F6QG66_HORSE/145-247                 ..........................SLRTGEDSTILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.TSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPSAEK..................................
A0A455AYU8_PHYMC/66-168              ..........................SLRTREDSTILP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPAAEK..................................
H0W6V1_CAVPO/109-211                 ..........................SLRTRGDLTILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVAVVSLRFKCRK.NKD.AEDPQKPG.SSGLSES..CSTAN...GEKH.SITLISMKNINMNNSKACPSAEK..................................
A0A2U4AGP7_TURTR/127-229             .........................n-LRTREDSTVLP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPSAEK..................................
A0A096N165_PAPAN/119-163             ................tpkfkckhps------------..----.-.-.-.-------..---------------------------.---.--------.----SPS..CSTAN...GEKD.RITLISMKNINMNNGKQSLSAEK..................................
A0A2D0SZP5_ICTPU/6-118               ...essvtenpvnttnmnvtqqtgdg---------AKP..TQTP.D.N.G.LTMLAFG..VMSFILILIIVMVILVTAVNFRGQCAN.TKE.--EGVKNY.VSVISEG..HISNM...GEKE.SIMLVSMRTINTDTD--------tdslri............................
A0A2U3VRJ9_ODORO/132-234             ........................sp--RTREDSSILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRK.NKE.SEDPQKPG.SPGLSES..CSTAN...GEKD.SITLISMKNINMNNSKGCPTAEK..................................
A0A2U3YXS7_LEPWE/132-198             ..........................SLRTREDSSILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRK.NKE.SEG-----.-------..-----...----.-----------------------tcpatqgp..........................
A0A2K6UWN6_SAIBB/132-234             .........................s-LSTREDVTILP..KPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVAVVSLRFKCRK.SKE.SEDPQKPG.SSGLSES..GSTAN...GEKD.SITLISMKNINMNNGKQSLSAEK..................................
#=GC seq_cons                        ............................phtt-.TlLP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIlLVSVVSLRFKCRK.sKE.SEDPQKPG.SSGLSES..CSTAN...GEKD.SITLISMKNINMNNSKussoAEK..................................
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