#=GF ID ECSCR
#=GF AC PF15820.5
#=GF DE Endothelial cell-specific chemotaxis regulator
#=GF AU Coggill P;0000-0001-5731-1588
#=GF SE Jackhmmer:Q19T08
#=GF GA 27.00 27.00;
#=GF TC 27.50 44.00;
#=GF NC 25.10 24.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 18556573
#=GF RT ECSM2, an endothelial specific filamin a binding protein that
#=GF RT mediates chemotaxis.
#=GF RA Armstrong LJ, Heath VL, Sanderson S, Kaur S, Beesley JF, Herbert
#=GF RA JM, Legg JA, Poulsom R, Bicknell R;
#=GF RL Arterioscler Thromb Vasc Biol. 2008;28:1640-1646.
#=GF RN [2]
#=GF RM 19416853
#=GF RT Identification of ARIA regulating endothelial apoptosis and
#=GF RT angiogenesis by modulating proteasomal degradation of cIAP-1 and
#=GF RT cIAP-2.
#=GF RA Ikeda K, Nakano R, Uraoka M, Nakagawa Y, Koide M, Katsume A,
#=GF RA Minamino K, Yamada E, Yamada H, Quertermous T, Matsubara H;
#=GF RL Proc Natl Acad Sci U S A. 2009;106:8227-8232.
#=GF DR INTERPRO; IPR026247;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC ECSCR, endothelial cell-specific chemotaxis regulator, is a
#=GF CC family of proteins found in eukaryotes. It is also known as ARIA
#=GF CC for apoptosis regulator through modulating IAP expression. It is
#=GF CC a cell surface protein that regulates endothelial chemotaxis and
#=GF CC tube formation, and interacts with filamin A. Filamin A anchors
#=GF CC transmembrane proteins to the actin cytoskeleton becoming a
#=GF CC scaffold for various signalling proteins. ECSCR is also known to
#=GF CC interact with and regulate the function of several endothelial
#=GF CC transmembrane molecules. It has been shown to play a role in
#=GF CC angiogenesis, a complex process involving the migration,
#=GF CC proliferation, and lumen formation of blood vessels by
#=GF CC endothelial cells [1]. ECSCR appears also to regulate
#=GF CC endothelial apoptosis, probably through modulating proteasomal
#=GF CC degradation of cIAP-1 and cIAP-2 in endothelial cells [2].
#=GF SQ 87
#=GS J9P6U8_CANLF/86-188 AC J9P6U8.1
#=GS F6RF12_MOUSE/83-160 AC F6RF12.1
#=GS A0A218UDP7_9PASE/129-239 AC A0A218UDP7.1
#=GS A0A0D9RKQ9_CHLSB/101-203 AC A0A0D9RKQ9.1
#=GS M3X1N0_FELCA/131-233 AC M3X1N0.2
#=GS G3UVV5_MOUSE/131-233 AC G3UVV5.1
#=GS F6QG66_HORSE/93-195 AC F6QG66.1
#=GS A0A1S3FGR3_DIPOR/64-166 AC A0A1S3FGR3.1
#=GS M3YCN1_MUSPF/119-221 AC M3YCN1.1
#=GS S9YRF6_CAMFR/32-135 AC S9YRF6.1
#=GS A0A1U8DGN5_ALLSI/57-163 AC A0A1U8DGN5.1
#=GS A0A2D0T033_ICTPU/37-135 AC A0A2D0T033.1
#=GS H0ZWL1_TAEGU/86-139 AC H0ZWL1.1
#=GS A0A091M0J8_CARIC/66-135 AC A0A091M0J8.1
#=GS W5N4A9_LEPOC/249-344 AC W5N4A9.1
#=GS A0A287B4P5_PIG/77-179 AC A0A287B4P5.1
#=GS A0A1A6FWE8_NEOLE/137-239 AC A0A1A6FWE8.1
#=GS A0A226PCT7_COLVI/137-219 AC A0A226PCT7.1
#=GS A0A287BAM3_PIG/77-179 AC A0A287BAM3.1
#=GS L9JUL1_TUPCH/111-181 AC L9JUL1.1
#=GS A0A1V4JW01_PATFA/152-252 AC A0A1V4JW01.1
#=GS A0A1U8D7P0_ALLSI/146-251 AC A0A1U8D7P0.1
#=GS A0A1S3L2R3_SALSA/157-253 AC A0A1S3L2R3.1
#=GS K7E312_MONDO/134-236 AC K7E312.1
#=GS A0A1U7SYA8_TARSY/132-234 AC A0A1U7SYA8.1
#=GS L5LBI5_MYODS/1-89 AC L5LBI5.1
#=GS U3IJL0_ANAPL/1-44 AC U3IJL0.1
#=GS A0A091CKV7_FUKDA/95-195 AC A0A091CKV7.1
#=GS F1RGG9_PIG/71-167 AC F1RGG9.2
#=GS A0A1U8D4Z5_ALLSI/129-234 AC A0A1U8D4Z5.1
#=GS L5JVF0_PTEAL/50-152 AC L5JVF0.1
#=GS M0RCJ4_RAT/120-222 AC M0RCJ4.2
#=GS A0A2I0LSR7_COLLI/144-246 AC A0A2I0LSR7.1
#=GS A0A0Q3LV18_AMAAE/188-289 AC A0A0Q3LV18.1
#=GS A0A1U7RMR7_ALLSI/122-227 AC A0A1U7RMR7.1
#=GS H0XIW9_OTOGA/101-203 AC H0XIW9.1
#=GS A0A151NR00_ALLMI/57-163 AC A0A151NR00.1
#=GS A0A1S3FHJ9_DIPOR/93-195 AC A0A1S3FHJ9.1
#=GS F1NUH5_CHICK/129-232 AC F1NUH5.2
#=GS A0A151NR41_ALLMI/74-180 AC A0A151NR41.1
#=GS A0A2K5NK98_CERAT/101-203 AC A0A2K5NK98.1
#=GS ECSCR_BOVIN/93-195 AC Q2KIX5.1
#=GS W5Q725_SHEEP/133-235 AC W5Q725.1
#=GS I3MWV9_ICTTR/135-237 AC I3MWV9.2
#=GS H0VUT2_CAVPO/124-226 AC H0VUT2.2
#=GS A0A093CSA9_9AVES/97-153 AC A0A093CSA9.1
#=GS A0A0R4ITT1_DANRE/127-227 AC A0A0R4ITT1.1
#=GS A0A1U8D7P8_ALLSI/82-187 AC A0A1U8D7P8.1
#=GS M7BWC6_CHEMY/118-207 AC M7BWC6.1
#=GS ECSCR_HUMAN/101-203 AC Q19T08.1
#=GS ECSCR_MOUSE/110-212 AC Q3TZW0.2
#=GS A0A1U8CRY6_MESAU/147-249 AC A0A1U8CRY6.1
#=GS K7E7N2_ORNAN/65-169 AC K7E7N2.1
#=GS G1RD79_NOMLE/55-104 AC G1RD79.2
#=GS G3SFD2_GORGO/101-203 AC G3SFD2.2
#=GS A0A226NCJ4_CALSU/137-217 AC A0A226NCJ4.1
#=GS A0A1S3FIB2_DIPOR/110-212 AC A0A1S3FIB2.1
#=GS A0A2K5HE07_COLAP/101-203 AC A0A2K5HE07.1
#=GS G5AZ74_HETGA/129-231 AC G5AZ74.1
#=GS G3U967_LOXAF/93-195 AC G3U967.1
#=GS G3USH6_MELGA/1-97 AC G3USH6.1
#=GS G1Q611_MYOLU/105-207 AC G1Q611.1
#=GS I3N472_ICTTR/118-220 AC I3N472.2
#=GS G3WC87_SARHA/77-180 AC G3WC87.1
#=GS G1U7J5_RABIT/97-201 AC G1U7J5.1
#=GS ECSCR_CANLF/71-173 AC P0C8R9.1
#=GS H2RHT1_PANTR/96-193 AC H2RHT1.2
#=GS A0A091EY12_CORBR/43-101 AC A0A091EY12.1
#=GS S7Q152_MYOBR/47-149 AC S7Q152.1
#=GS K7G2T4_PELSI/54-174 AC K7G2T4.1
#=GS A0A151NQS2_ALLMI/99-204 AC A0A151NQS2.1
#=GS A0A1S3W4C6_ERIEU/130-232 AC A0A1S3W4C6.1
#=GS K7EVF1_PONAB/95-159 AC K7EVF1.1
#=GS W5KDY9_ASTMX/141-242 AC W5KDY9.1
#=GS A0A1V4JVZ9_PATFA/142-243 AC A0A1V4JVZ9.1
#=GS G1LXM5_AILME/133-235 AC G1LXM5.1
#=GS G3U8D7_LOXAF/98-200 AC G3U8D7.1
#=GS A0A1S3FH11_DIPOR/84-186 AC A0A1S3FH11.1
#=GS E7F0W6_DANRE/125-225 AC E7F0W6.1
#=GS K7A467_PANTR/101-203 AC K7A467.1
#=GS F6W6D3_MOUSE/83-156 AC F6W6D3.1
#=GS U3JJY1_FICAL/1-79 AC U3JJY1.1
#=GS H0W6V1_CAVPO/109-211 AC H0W6V1.2
#=GS A0A1S3FGQ8_DIPOR/130-232 AC A0A1S3FGQ8.1
#=GS A0A096N165_PAPAN/119-163 AC A0A096N165.2
#=GS A0A2D0SZP5_ICTPU/6-118 AC A0A2D0SZP5.1
#=GS A0A091MTK3_9PASS/49-96 AC A0A091MTK3.1
J9P6U8_CANLF/86-188 .......................SLRIREDST..ILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVSVVSLRFKCRKNKESEDPQKPG.SSGLSES..CSTANGEKD.SITLISMKNINMNNSKGCPTAEK..................................
F6RF12_MOUSE/83-160 ...............tkkmtill--------T..ILP..TPTS.E.S.V.LTVAAFG..VISFIVILVVVVIILVSVVSLRFKCRKNKESEDPQKPG.SSGLSER..---------.-----------------------ffksdle...........................
A0A218UDP7_9PASE/129-239 ......asepitptpnsssqlpe---------..--P..TPTD.E.KsP.LTVAAFG..VISFVVILIVVVIILVSVVSLRFKCNHSKDSEDKQKPG.TSMVSES..CSADTSQKGnSITLISMKNINTNNSMNYPPSEK..................................
A0A0D9RKQ9_CHLSB/101-203 .......................SLSMREDAT..ILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCRKSKESEDPQKPG.SSGLPES..CSTANGEKD.RITLISMKNINMNNGKQSLSAEK..................................
M3X1N0_FELCA/131-233 .......................SLRTRDDST..ILP..TPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVSVVSLRFKCRKNKESEDPQKPG.SSGLSES..CSTANGEKD.SITLISMKNINMNNSKGCPTAEK..................................
G3UVV5_MOUSE/131-233 ...............tkkmtill--------T..ILP..TPTS.E.S.V.LTVAAFG..VISFIVILVVVVIILVSVVSLRFKCRKNKESEDPQKPG.SSGLSES..CSTANGEKD.SITLISMRNINVNNSKGSMSAEK..................................
F6QG66_HORSE/93-195 .......................SLRTGEDST..ILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRKNKESEDPQKPG.TSGLSES..CSTANGEKD.SITLISMKNINMNNSKGCPSAEK..................................
A0A1S3FGR3_DIPOR/64-166 .......................SLRTRGNLT..IVP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCRKNKEPEDPQKPG.NSGVSES..CSTANGEKD.SITLISVKNINMNNSKGCPSAEK..................................
M3YCN1_MUSPF/119-221 .......................SLRTKEDLS..VLP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRKNKESEDPQKPG.SSGLSES..CSTANGEKD.SITLISMKNINMNNSKGYPTAEK..................................
S9YRF6_CAMFR/32-135 .................tmslrt-----GDST..ILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCQKNKESEDPQKPG.SSGLSES..CSTANGEKD.SITLISMKNINMNNSKGCASAEK..................................
A0A1U8DGN5_ALLSI/57-163 .........eaisaentmispsa---------..--I..TPTE.K.S.G.LEIVAFG..VIGFIGILVVVVFILVGVVYLRFRCNHSKDAEDKQKPE.DPVVSES..CSAATNRKNsSVTLISMKNINMNNSLSYPTSEK..................................
A0A2D0T033_ICTPU/37-135 ..............nvtqqtgdg---------..AKP..TQTP.D.N.G.LTMLAFG..VMSFILILIIVMVILVTAVNFRGQCANTKE--EGVKNY.VSVISEG..HISNMGEKE.SIMLVSMRTINTDTD--------tdslri............................
H0ZWL1_TAEGU/86-139 ..............xxxncpspp---------..---..-DRR.E.S.P.LTVAAFG..VISFVVILIVVVIILVSVVSLRFKCNHSKDSE------.-------..---------.-----------------------..................................
A0A091M0J8_CARIC/66-135 ..satqgiskpvtptptssgylp---------..-VP..TPTD.DkS.P.LTVAAFG..VISFIVILIVVVIILVSVVSLRFKCNRSKDSE------.-------..---------.-----------------------..................................
W5N4A9_LEPOC/249-344 ..........rgqdstsavkeps---------..---..----.-.S.S.LSMLAFG..VMSFILILIIVMVVLVTAVNLRGRCRGSRD--EGKKSG.DSVVSES..NITVNGEKE.SITLVSMKTINTETDTDS-----pris..............................
A0A287B4P5_PIG/77-179 .......................SLRTREDPT..VLP..SPTS.E.T.V.LTVAAFG..VISFIVILLVVVIILVSVVSLRFKCRKNKESEDPQKPG.SSGLSES..CSTANGEKD.SITLISMKNINMNNSKGCPSAEK..................................
A0A1A6FWE8_NEOLE/137-239 .......................SLRTREDVT..ILP..SPTS.E.S.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRKNKESEDPQKPG.SSGISES..CSTANGEKD.SITLISMKNINMNNSKGCTSAEK..................................
A0A226PCT7_COLVI/137-219 ...............qeisvsls---------..-VP..TPTEyE.S.P.LTVVAFG..VISFIVILVVVVIILVSVVSLRFKCNRSKDSEDKQKPG.NSMVSER..CYEANN---.-----------------------peqeadt...........................
A0A287BAM3_PIG/77-179 .......................SLRTREDPT..VLP..SPTS.E.T.V.LTVAAFG..VISFIVILLVVVIILVSVVSLRFKCRKNKESEDPQKPG.SSGLSES..CSTANGEKD.SITLISMKNINMNNSKGCPSAEK..................................
L9JUL1_TUPCH/111-181 ..............tppqpqkht---------..---..----.-.-.-.---SGLG..VISFIVILVVVVIILVGVVSLRFKCRKNKESEDPQKPG.SSGLSER..I--------.-----------------------kkcrnyyeilgv......................
A0A1V4JW01_PATFA/152-252 .................lsgylt---------..-TP..TPTD.E.K.SpLTVAAFG..VISFIVILIVVVIILVSVVSLRFKCNRSKDSEDKQKPG.TSVVSES..CSAGTSQKEnSITLISMKNINTNNSRSYPPSEK..................................
A0A1U8D7P0_ALLSI/146-251 ..........aisaentmispsa---------..--I..TPTE.K.S.G.LEIVAFG..VIGFIGILVVVVFILVGVVYLRFRCNHSKDAEDKQKPE.DPVVSES..CSAATNRKNsSVTLISMKNINMNNSLSYPTSEK..................................
A0A1S3L2R3_SALSA/157-253 ...................kgth-------TD..IPP..TQSP.D.K.S.LTMLAFG..VMSLILILVIIMVVLVTVVNLKDKCSHSKE--EGKKSS.DSVVSES..NVTFSGEKE.SITLISMKTINTETDTDS-----pqvs..............................
K7E312_MONDO/134-236 ..................mdlra-----TEKP..ILP..TPTS.E.T.V.LTVAAFG..VITFIIILVVVVIILVSVVSLRFKCRKNKESEDPQKPE.ICGMFES..-STAIGEKDtSITLISMKNINSNNNKGSYTEEK..................................
A0A1U7SYA8_TARSY/132-234 ......................s-LSTREALT..ILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCQKNKEAEDPQKPG.SSGLSES..CSTANGEKD.SITLISMKNINMNNSKGHLSAEK..................................
L5LBI5_MYODS/1-89 ......................m---------..---..---S.E.Q.V.LTVAAFG..VISFIVILVVVVIILVSVVSLRFKCQKNKESEDPQKPG.SSGLSES..CSAANGEKD.SITLISMKNINMNNSKGCRSAEK..................................
U3IJL0_ANAPL/1-44 .......................---------..---..----.-.-.-.------G..VISFIVILVVVVIILVSVVSLRFKCNRSKDSEDKQKPG.SSMV---..---------.-----------------------s.................................
A0A091CKV7_FUKDA/95-195 ..................attms-------LT..ILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCRKNKDSEDPQKPG.SSGLSES..CSTANGEKD.SITLISMKNINMNNSRGCPSAEK..................................
F1RGG9_PIG/71-167 .......................SLRTREDPT..VLP..SPTS.E.T.V.LTVAAFG..VISFIVILLVVVIILVSVVSLRFKCRKNKESEGT-RPD.P-----R..CSTANGEKD.SITLISMKNINMNNSKGCPSAEK..................................
A0A1U8D4Z5_ALLSI/129-234 ..........aisaentmispsa---------..--I..TPTE.K.S.G.LEIVAFG..VIGFIGILVVVVFILVGVVYLRFRCNHSKDAEDKQKPE.DPVVSES..CSAATNRKNsSVTLISMKNINMNNSLSYPTSEK..................................
L5JVF0_PTEAL/50-152 .......................SLRTREDST..ILA..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRKNKESEDPQKPG.SSGLSES..CSTANGEKD.SITLISMKNINMNNSKGCPSAEK..................................
M0RCJ4_RAT/120-222 ..................sslrt-----KEGT..ILP..TPTS.E.S.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRKNKESEDPQKPG.SSGLSES..CSTANGEKD.SITLISMKNINTNNSKGCTSAEK..................................
A0A2I0LSR7_COLLI/144-246 ..............tvpsgylpt---------..--P..TPTD.DkS.P.LTVAAFG..VISFIVILIVVVIILVSVVSLRFKCNRSKDSEDKQKPG.TSVVSES..CSAGTSQKEnSITLISMKNINTNNSRSYPPSEK..................................
A0A0Q3LV18_AMAAE/188-289 ................mssgylp---------..-VP..TPTD.DkS.P.LTVAAFG..VISFIVILIVVVIILVSVVSLRFKCNRSKDSEDKQKPG.TSMVSES..CSAGTSQKDnSITLISMKNINMNNSMSYPPSEK..................................
A0A1U7RMR7_ALLSI/122-227 ..........aisaentmispsa---------..--I..TPTE.K.S.G.LEIVAFG..VIGFIGILVVVVFILVGVVYLRFRCNHSKDAEDKQKPE.DPVVSES..CSAATNRKNsSVTLISMKNINMNNSLSYPTSEK..................................
H0XIW9_OTOGA/101-203 ....................sps---ARDDLG..ILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVSVVSLRFKCRKNKESEDPQKPG.SSGLSES..CSTAGREKD.SITLISMKNINMNSSKGCNSAEK..................................
A0A151NR00_ALLMI/57-163 .........eaisaentmispsa---------..--I..TPTE.K.S.G.LEIVAFG..VIGFIGILVVVVFILVGVVYLRFRCNHSKDAEDKQKPE.DPVVSES..CSAATNRKNsSVTLISMKNINMNNSLSYPTSEK..................................
A0A1S3FHJ9_DIPOR/93-195 .......................SLRTRGNLT..IVP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCRKNKEPEDPQKPG.NSGVSES..CSTANGEKD.SITLISVKNINMNNSKGCPSAEK..................................
F1NUH5_CHICK/129-232 ..............aleisvslp---------..-VP..TPTEyE.S.P.LTVVAFG..VISFIVILVVIVIILVSVVSLRFKCNRSKDSEDKQKPG.SSMVSEG..CSAGTSEKDnSITLISMKNINMNNSMTYPPSEK..................................
A0A151NR41_ALLMI/74-180 .........eaisaentmispsa---------..--I..TPTE.K.S.G.LEIVAFG..VIGFIGILVVVVFILVGVVYLRFRCNHSKDAEDKQKPE.DPVVSES..CSAATNRKNsSVTLISMKNINMNNSLSYPTSEK..................................
A0A2K5NK98_CERAT/101-203 .......................SLSMREDAT..ILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCRKSKESEDPQKPG.SSGLSES..CSTANGEKD.RITLISMKNINMNNGKQSLSAEK..................................
ECSCR_BOVIN/93-195 ......................s-FRTTADST..VPP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIVLVSVVSLRFKCRKNKESEDPQKPG.SSGLSES..GSTANGEKE.SITLISMKNINMNNSKGCPSAEK..................................
W5Q725_SHEEP/133-235 ......................s-FRMTADST..VPP..SPTS.E.T.V.LTVAAFG..VISFIAILVVVVIVLVSVVSLRFKCQKNKESEDPQKPG.SSGLSES..GSTANGEKE.SITLISMKNINMNNSKGCPSAEK..................................
I3MWV9_ICTTR/135-237 ....................nss---MMEDLT..ILP..SPTL.A.T.V.LTVAAFG..VISFIVILVVVVIILVAVVSLRFKCRKNKESEDPQKPG.SSGLSES..CSTANGEKD.SITLISMKNINMNNSKGCPSAEK..................................
H0VUT2_CAVPO/124-226 .......................SLRTRGDLT..ILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVAVVSLRFKCRKNKDAEDPQKPG.SSGLSES..CSTANGEKH.SITLISMKNINMNNSKACPSAEK..................................
A0A093CSA9_9AVES/97-153 ...............pmssgylp---------..-VP..TPTD.DkS.P.LTVAAFG..VISFIVILIVVVIILVSVVSLRFKCNRSKDSE------.-------..---------.-----------------------..................................
A0A0R4ITT1_DANRE/127-227 .................snisms------EAT..ATP..SPA-.E.S.R.LTLLAFG..VMSLILILIVVMVILVAAVNLKGRCCRNTQQHESIKNR.DSLVSDS..NLTSNGEKE.NITLVSVRTINTEYNADSP----qis...............................
A0A1U8D7P8_ALLSI/82-187 ..........aisaentmispsa---------..--I..TPTE.K.S.G.LEIVAFG..VIGFIGILVVVVFILVGVVYLRFRCNHSKDAEDKQKPE.DPVVSES..CSAATNRKNsSVTLISMKNINMNNSLSYPTSEK..................................
M7BWC6_CHEMY/118-207 ................tgpslpd---------..--P..VPTE.EkS.A.LTMAAFG..VISFIVVLVVVVIVLASVVSLRFKCNRSKDAEA-----.-------..---------.-----------------------lidalrrnacpteensessdfcacsdcmrgkkek
ECSCR_HUMAN/101-203 .......................SLSMREDAT..ILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVGVVSLRFKCRKSKESEDPQKPG.SSGLSES..CSTANGEKD.SITLISMKNINMNNGKQSLSAEK..................................
ECSCR_MOUSE/110-212 ...............tkkmtill--------T..ILP..TPTS.E.S.V.LTVAAFG..VISFIVILVVVVIILVSVVSLRFKCRKNKESEDPQKPG.SSGLSES..CSTANGEKD.SITLISMRNINVNNSKGSMSAEK..................................
A0A1U8CRY6_MESAU/147-249 ....................slw---TGEEVT..ILP..SPTS.E.S.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRKNKESEDPQKPG.SSGLSES..CSAASGEKD.SITLLSMKSINMDNSKGCPSAEK..................................
K7E7N2_ORNAN/65-169 ...........alvrtqagpias---------..-QP..SPTE.K.S.V.LTVAAFG..VISFIVILVIVVIVLVSVVSLRFRCNRNKESENAQKPG.ISGVSES..CSPANGEKE.RITLISMKNINTNNSKGCSTAEK..................................
G1RD79_NOMLE/55-104 ..................ipssd---------..---..----.-.-.-.-------..---------------------------------ANSPShLSSTGTP..CSTANGEKD.SITLISMKNINMNNGKQSLSAEK..................................
G3SFD2_GORGO/101-203 .......................SLSMREDAT..ILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVGVVSLRFKCRKSKESEDPQKPG.SSGLSES..CSTANGEKD.SITLISMKNINMNNGKQSLSAEK..................................
A0A226NCJ4_CALSU/137-217 ...............qeisvsls---------..-VP..TPTEyE.S.P.LTVVAFG..VISFIVILVVVVIILVSVVSLRFKCNRSKDSEDKQKPG.NSMVSER..CYEAN----.-----------------------npelea............................
A0A1S3FIB2_DIPOR/110-212 .......................SLRTRGNLT..IVP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCRKNKEPEDPQKPG.NSGVSES..CSTANGEKD.SITLISVKNINMNNSKGCPSAEK..................................
A0A2K5HE07_COLAP/101-203 .......................SLSMREDAT..ILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCRKSKESEDPQKPG.SSGLSES..CSTANGEKD.SITLISMKNINMNNGKQSLSAEK..................................
G5AZ74_HETGA/129-231 .......................SLRTREDLT..ILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCRKNKDSEDPQKPG.SSGLSES..CSTANGEKD.SITLISMKNINMNNSKACPSAEK..................................
G3U967_LOXAF/93-195 ......................s-LRTGEYLT..ILP..SPTS.E.S.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRKNKESEDPQKPG.SSGISES..CSTANGEKD.SITLISMKNINTNNSKRWSSAEK..................................
G3USH6_MELGA/1-97 .......................---------..-MP..TPTEyE.S.P.LTVVAFG..VISFIVILVVVVIILVSVVSLRFKCNRSKDSEDKQKPG.SSMVSESdsCSAGTSEKDnSITLISMKNINMNNSMTYPPSEK..................................
G1Q611_MYOLU/105-207 .....................sp--RTREDPT..ILP..SPMS.E.Q.V.LTVAAFG..VISFIVILVVVVIILVSVVSLRFKCQKNKESEDPQKPG.SSGLSES..CSAANGEKD.SITLISMKNINMNNSKGCRSAEK..................................
I3N472_ICTTR/118-220 ....................nss---MMEDLT..ILP..SPTL.A.T.V.LTVAAFG..VISFIVILVVVVIILVAVVSLRFKCRKNKESEDPQKPG.SSGLSES..CSTANGEKD.SITLISMKNINMNNSKGCPSAEK..................................
G3WC87_SARHA/77-180 ...................mdlr----TTEKP..VLP..TPTS.E.T.V.LTVAAFG..VITFIIILVVVVIILVSVVSLRFKCQKNKESEDPQKPD.SCGMSES..SSTANREKDtSITLISMKNINSNNNKGCFTEEK..................................
G1U7J5_RABIT/97-201 ......................t-LRTRDDLS..ILP..SPTS.E.T.V.LTVAAFGsgVISFIVILVVVVIVLVSVVSLRFKCRKNKESEDPQKPG.SSGVSES..CSTANGEKD.SITLISMKNINTNNSKGCPSAEK..................................
ECSCR_CANLF/71-173 .......................SLRIREDST..ILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVSVVSLRFKCRKNKESEDPQKPG.SSGLSES..CSTANGEKD.SITLISMKNINMNNSKGCPTAEK..................................
H2RHT1_PANTR/96-193 .......................SLSMREDAT..ILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVGVVSLRFKCRKSKESEGA--PP.S---SPS..CSTANGEKD.SITLISMKNINMNNGKQSLSAEK..................................
A0A091EY12_CORBR/43-101 ............ptpnhsshlpq---------..--P..SPTD.E.KsP.LTVAAFG..VISFVVILIVVVIILVSVVSLRFKCNHSKDP-------.-------..---------.-----------------------e.................................
S7Q152_MYOBR/47-149 .....................sp--RTREDPT..ILP..SPMS.E.Q.V.LTVAAFG..VISFIVILVVVVIILVSVVSLRFKCQKNKESEDPQKPG.SSGLSES..CSAANGEKD.SITLISMKNINMNNSKGCRSAEK..................................
K7G2T4_PELSI/54-174 ..kptaggaseqlpstastsdrs------TSP..ALPdpAPTE.EkS.A.LTMAAFG..VISFIVILVVVVIILVSVVSLRFKCTRAKDTEDKQKPG.SSVVSES..CSAATAKKS.SVTLISMKDLSMNNSATYPTSEK..................................
A0A151NQS2_ALLMI/99-204 ..........aisaentmispsa---------..--I..TPTE.K.S.G.LEIVAFG..VIGFIGILVVVVFILVGVVYLRFRCNHSKDAEDKQKPE.DPVVSES..CSAATNRKNsSVTLISMKNINMNNSLSYPTSEK..................................
A0A1S3W4C6_ERIEU/130-232 ..................mslrt-----RDLV..IQP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRKNKESEDPQKPG.NSGLSES..CSTANGEKD.RITLISMKNINTNNSKGCPSAEK..................................
K7EVF1_PONAB/95-159 .......................SLSMREDVT..ILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCRKSKESEG-----.-------..---------.-----------------------vcpalg............................
W5KDY9_ASTMX/141-242 ....................slr---RSTDEPtaVPP..TQPP.G.N.S.LTMLAFG..VMSFILVLIIVMIILVTAVNLRGRCHNTKE--EGVKNY.DSVISES..NLTSTGEKE.SITLVSVRSINTDADTDS-----pqis..............................
A0A1V4JVZ9_PATFA/142-243 ................vlsgylt---------..-TP..TPTD.E.K.SpLTVAAFG..VISFIVILIVVVIILVSVVSLRFKCNRSKDSEDKQKPG.TSVVSES..CSAGTSQKEnSITLISMKNINTNNSRSYPPSEK..................................
G1LXM5_AILME/133-235 ......................n-LRTGEDLS..VLP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRKNKESEDPQKPG.SSGLSES..CSAANGEKD.SITLISMKNINMNNSKGCPTAEK..................................
G3U8D7_LOXAF/98-200 ......................s-LRTGEYLT..ILP..SPTS.E.S.V.LTVAAFG..VISFIVILVVVVIVLVSVVSLRFKCRKNKESEDPQKPG.SSGISES..CSTANGEKD.SITLISMKNINTNNSKRWSSAEK..................................
A0A1S3FH11_DIPOR/84-186 .......................SLRTRGNLT..IVP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCRKNKEPEDPQKPG.NSGVSES..CSTANGEKD.SITLISVKNINMNNSKGCPSAEK..................................
E7F0W6_DANRE/125-225 .................snisms------EAT..ATP..SPA-.E.S.R.LTLLAFG..VMSLILILIVVMVILVAAVNLKGRCCRNTQQHESIKNR.DSLVSDS..NLTSNGEKE.NITLVSVRTINTEYNADSP----qis...............................
K7A467_PANTR/101-203 .......................SLSMREDAT..ILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIILVGVVSLRFKCRKSKESEDPQKPG.SSGLSES..CSTANGEKD.SITLISMKNINMNNGKQSLSAEK..................................
F6W6D3_MOUSE/83-156 ...............tkkmtill--------T..ILP..TPTS.E.S.V.LTVAAFG..VISFIVILVVVVIILVSVVSLRFKCRKNKESEDPQKPG.SSGLSER..---------.-----------------------vfw...............................
U3JJY1_FICAL/1-79 .......................---------..---..----.-.-.-.------G..VISFVVILIVVVIILVSVVSLRFKCNHSKDSEDKQKPG.SSMVSES..CSADTSQKGnSITLISMKNINTNNSMSYPPSEK..................................
H0W6V1_CAVPO/109-211 .......................SLRTRGDLT..ILP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVAVVSLRFKCRKNKDAEDPQKPG.SSGLSES..CSTANGEKH.SITLISMKNINMNNSKACPSAEK..................................
A0A1S3FGQ8_DIPOR/130-232 .......................SLRTRGNLT..IVP..SPTS.E.T.V.LTVAAFG..VISFIVILVVVVIVLVGVVSLRFKCRKNKEPEDPQKPG.NSGVSES..CSTANGEKD.SITLISVKNINMNNSKGCPSAEK..................................
A0A096N165_PAPAN/119-163 .............tpkfkckhps---------..---..----.-.-.-.-------..--------------------------------------.----SPS..CSTANGEKD.RITLISMKNINMNNGKQSLSAEK..................................
A0A2D0SZP5_ICTPU/6-118 essvtenpvnttnmnvtqqtgdg---------..AKP..TQTP.D.N.G.LTMLAFG..VMSFILILIIVMVILVTAVNFRGQCANTKE--EGVKNY.VSVISEG..HISNMGEKE.SIMLVSMRTINTDTD--------tdslri............................
A0A091MTK3_9PASS/49-96 .................sgylpe---------..--P..TPTD.DkS.P.LTVAAFG..VISFVVILIVVVIILVSVVSLRFKC-------------.-------..---------.-----------------------n.................................
#=GC seq_cons ...............................s..hlP..oPTs.E.o.s.LTVAAFG..VISFIVILVVVVIILVoVVSLRFKCp+sK-SEDsQKPG.sSslSES..CSsAsGEK-.SITLISMKNINhNNS+sh.ouEK..................................
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