GenomeNet

Database: Pfam
Entry: Endonuc-EcoRV
LinkDB: Endonuc-EcoRV
Original site: Endonuc-EcoRV 
#=GF ID   Endonuc-EcoRV
#=GF AC   PF09233.12
#=GF DE   Restriction endonuclease EcoRV
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   pdb_1sx5
#=GF GA   25.00 25.00;
#=GF TC   33.10 29.10;
#=GF NC   24.70 24.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   15170321
#=GF RT   DNA cleavage by EcoRV endonuclease: two metal ions in three
#=GF RT   metal ion binding sites. 
#=GF RA   Horton NC, Perona JJ; 
#=GF RL   Biochemistry. 2004;43:6841-6857.
#=GF RN   [2]
#=GF RM   22638584
#=GF RT   Sequence, structure and functional diversity of PD-(D/E)XK
#=GF RT   phosphodiesterase superfamily.
#=GF RA   Steczkiewicz K, Muszewska A, Knizewski L, Rychlewski L, Ginalski
#=GF RA   K;
#=GF RL   Nucleic Acids Res. 2012;40:7016-7045.
#=GF DR   INTERPRO; IPR015314;
#=GF DR   SCOP; 1sx5; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Members of this family of prokaryotic restriction endonucleases
#=GF CC   recognise the double-stranded sequence 5'-GATATC-3' and cleave
#=GF CC   after T-3. They catalyse the endonucleolytic cleavage of DNA to
#=GF CC   give specific double-stranded fragments with terminal
#=GF CC   5'-phosphates [1].
#=GF SQ   75
#=GS A0A160T8S3_9CHLR/20-256   AC A0A160T8S3.1
#=GS A0A410PQ05_9CLOT/12-248   AC A0A410PQ05.1
#=GS A0A1Q5Q2A6_9ACTO/12-243   AC A0A1Q5Q2A6.1
#=GS A0A143YHL6_9LACT/16-247   AC A0A143YHL6.1
#=GS A0A0J1GMI1_9GAMM/17-257   AC A0A0J1GMI1.1
#=GS A0A146G3S4_TERSA/27-186   AC A0A146G3S4.1
#=GS V8C971_9HELI/20-257       AC V8C971.1
#=GS A0A4U8SL65_9HELI/20-258   AC A0A4U8SL65.1
#=GS A0A109CPZ5_9BACT/26-267   AC A0A109CPZ5.1
#=GS A0A2T6ADP3_9RHOB/48-257   AC A0A2T6ADP3.1
#=GS R2PL54_9ENTE/16-254       AC R2PL54.1
#=GS A5V954_SPHWW/49-249       AC A5V954.1
#=GS A0A1E8Q1V1_9MYCO/47-244   AC A0A1E8Q1V1.1
#=GS A0A059FE26_9RHOB/11-244   AC A0A059FE26.1
#=GS A0A2G5L7H7_9FLAO/22-265   AC A0A2G5L7H7.1
#=GS R5AHW7_9CLOT/23-263       AC R5AHW7.1
#=GS R5BH01_9FIRM/18-248       AC R5BH01.1
#=GS L7UJD8_MYXSD/12-159       AC L7UJD8.1
#=GS I1B2G6_9RHOB/11-244       AC I1B2G6.1
#=GS G2PQ61_MURRD/22-265       AC G2PQ61.1
#=GS R7EWJ3_9BACT/1-95         AC R7EWJ3.1
#=GS R5RMA3_9CLOT/12-247       AC R5RMA3.1
#=GS F9D0Q7_PREDD/20-249       AC F9D0Q7.1
#=GS M0QFW5_9ACTN/37-255       AC M0QFW5.1
#=GS E7G3V5_9HELI/7-227        AC E7G3V5.1
#=GS A0A0N0AIM2_9ACTN/48-260   AC A0A0N0AIM2.1
#=GS A0A081C4V8_9BACT/25-266   AC A0A081C4V8.1
#=GS A0A109B9Q5_HYPSL/48-250   AC A0A109B9Q5.1
#=GS Q7VJK4_HELHP/20-258       AC Q7VJK4.1
#=GS A0A2M9BBH2_9MICO/22-263   AC A0A2M9BBH2.1
#=GS A0A251X955_9GAMM/4-76     AC A0A251X955.1
#=GS A0A3A9EFW6_9FIRM/11-242   AC A0A3A9EFW6.1
#=GS A0A1X1R392_9MYCO/49-254   AC A0A1X1R392.1
#=GS A0A222EAQ4_9RHOB/22-265   AC A0A222EAQ4.1
#=GS W0F5I3_9BACT/20-257       AC W0F5I3.1
#=GS A0A1Q2SL26_9GAMM/1-48     AC A0A1Q2SL26.1
#=GS A0A377PWD4_9HELI/1-210    AC A0A377PWD4.1
#=GS D3IKT3_9BACT/20-257       AC D3IKT3.1
#=GS A0A090IN15_9GAMM/16-259   AC A0A090IN15.1
#=GS A0A1A3JKE7_9MYCO/49-257   AC A0A1A3JKE7.1
#=GS R7J2P1_9BACT/1-96         AC R7J2P1.1
#=GS A0A1H6K708_9GAMM/20-261   AC A0A1H6K708.1
#=GS A0A369QWQ1_9RHOB/11-245   AC A0A369QWQ1.1
#=GS A0A255Z9I3_9FLAO/178-287  AC A0A255Z9I3.1
#=GS R5APG6_9BACT/20-257       AC R5APG6.1
#=GS A0A2H5WS21_9BACT/32-271   AC A0A2H5WS21.1
#=GS R4TMS2_9VIRU/10-197       AC R4TMS2.1
#=GS A0A139SQA4_9GAMM/25-266   AC A0A139SQA4.1
#=GS R9M6W0_9FIRM/11-241       AC R9M6W0.1
#=GS I4F1M5_9ACTN/33-237       AC I4F1M5.1
#=GS S0ITX6_9FIRM/12-248       AC S0ITX6.1
#=GS A0A1J0AAT7_9CYAN/20-257   AC A0A1J0AAT7.1
#=GS A0A495D831_9ALTE/21-262   AC A0A495D831.1
#=GS A0A495KNK5_9FLAO/207-315  AC A0A495KNK5.1
#=GS V2RL55_9BACT/20-257       AC V2RL55.1
#=GS A0A495KNK5_9FLAO/55-213   AC A0A495KNK5.1
#=GS A0A0F0H835_NOCAE/16-239   AC A0A0F0H835.1
#=GS A0A091FGK0_9DELT/9-246    AC A0A091FGK0.1
#=GS A0A251X9H2_9GAMM/7-98     AC A0A251X9H2.1
#=GS A0A255Z9I3_9FLAO/27-182   AC A0A255Z9I3.1
#=GS A0A316E928_9BACT/27-268   AC A0A316E928.1
#=GS C3J9L6_POREA/20-256       AC C3J9L6.1
#=GS R7J2H7_9BACT/20-147       AC R7J2H7.1
#=GS R6C8U6_9CLOT/24-263       AC R6C8U6.1
#=GS D0KWR7_HALNC/21-262       AC D0KWR7.1
#=GS A0A401G309_9DELT/17-78    AC A0A401G309.1
#=GS A0A401G4I6_9DELT/21-262   AC A0A401G4I6.1
#=GS A0A095Y7K5_9BACT/20-257   AC A0A095Y7K5.1
#=GS A0A1X1QRW9_9GAMM/20-261   AC A0A1X1QRW9.1
#=GS A0A1Q8CRU8_9PSEU/48-253   AC A0A1Q8CRU8.1
#=GS A0A347WNW4_9LACT/15-248   AC A0A347WNW4.1
#=GS A0A1Q2SL21_9GAMM/22-184   AC A0A1Q2SL21.1
#=GS A0A146G3S4_TERSA/191-305  AC A0A146G3S4.1
#=GS B0JX72_MICAN/20-257       AC B0JX72.1
#=GS A0A1T4UEB9_9GAMM/17-258   AC A0A1T4UEB9.1
A0A160T8S3_9CHLR/20-256              .........................................a-VSTAQGDWVVKGFIDVARNIYTISTDTKVVSKVMELLLFPELV.RF.AQENN..LKLHLAEQQNFYPDVTFIDEEN....H..-....LFAVDLKSTYRVNSVR........TNGMTLGAFTGYFRT.R.G.SK.K.NCSFPYEDYTGHF.VLGV..IYSPVYG..-VDERRRYSLDDLELISSVITDFQFYAQEKFRIASDRPGSGNTKNIGSV..L.GIQDLIAGTGPFNELG..EE..IFNDYWMYF----..LTaDMAR.A.A.ELPNrpYTNLQTYRIYK-g..................
A0A410PQ05_9CLOT/12-248              .........................................k-ISQRNINWEVKGLVSANGNIFTLGSDSKLIGRIFELIVTPVLN.EI.AADNG..YNLVASDQQTVYPDFTMLRNEN....D..T...dKIAIDIKTTYRRFKRNge....lkKFGYTLGSFASFM--.R.N.NT.K.NIMYPYDTYSKHY.VIGF..LYSRNDY..AI-EGQMVNSAALNTIPTPYSDVEFFVQEKYKIAGDKPGSGNTENMGSFgtT.DINELRLGNGPFSVLG..ND..IYEDYWRNYPKYR..--.----.-.E.NNNS..YNSLNTYFNW--la.................
A0A1Q5Q2A6_9ACTO/12-243              .....................................kkmet------VDLNVYGILGTDDKVHSLGTDSKIIGRVFEILAQPVLE.EI.AAEHN..LSIITPASQTVYPDFVLMDDPD....S..T...eKIAVDIKTTYVASERS........QIKFTLGAFASYM--.R.N.NT.K.NIEYKYTDYAKHY.VIGF..VYNRNGF..-AQESKVFDFADRASIETPYTNVKYFMQEKYRISGDKPGSGNTENIGSIrtR.NFEDSVEGNSPFATLG..ED..VYDLYWANYPKYR..--.S---.-.-.ANKA..YTSLPEFLEW--lp.................
A0A143YHL6_9LACT/16-247              .........................................k-VCEMNIDWNVKGLIANADTVYAIGNDSKLLGRIFEIVSAPVIK.AI.ADEYG..YIVKTPDKQNTYPDFTLMRSED....D..P...qKIAIDIKTTYKQGNRK........LN-FTLGSFTSFM--.R.N.NT.K.NIQYPYSTYANHY.VIGF..IYERNL-..EAEEGSIVTYNDLDSLAIPYLNVDYFVRKKKDINGQKKGSGNTDNMSSIicT.NVNEFKTFTGPFSNLP..KK..LYLHYWRNYSKNT..--.ESP-.-.-.--KV..YIDLDSYFNW--le.................
A0A0J1GMI1_9GAMM/17-257              .......................................ltq-----GFTWEIQGFIDQNNNVLPIDSDTKVLSTVFERFASPALR.SL.AAEKG..YVVETA-NQTTYPDFTLTKYDAfgnvE..H....RIALDIKSTYIEPKVPfg....ykKTKMTLGSYNSFI--.R.N.NT.K.NILYPYNTYHEHW.VLGF..VYIRNEA..-FEEYTLENIPTRGQIRCPYSVQSVFIREKVDLTGIRAGSGNTKNIGSVeiD.TPNGFETVNGPFTQFR..DKkgACDFYWANYEEAK..--.----.-.-.----..------------eqifdwhslynhpemarfk
A0A146G3S4_TERSA/27-186              .........................................y-VSSEDGQWAVKGFIDVFRNIYTITADTKIVSKILEVHLFPKIL.AF.AEEHN..LKVVLAEKQNWYPDFSFVGAAD....P..E...iKFAVDLKTTYRDPDRPg......yVNGFTLGSHGEYFTN.R.S.ST.K.NIQFPYKDYFGHF.CLGA..IYTRTVE.eDLTGMEVYSVKELGS----------------------------------..-.----------------..--..-------------..--.----.-.-.----..------------dpaaae.............
V8C971_9HELI/20-257                  .......................................kic----QNDEWKIKGFIDSDKNIFSLSNDTKVISKILEIHIFPYIL.DF.AKQNG..FEIILPTYQNYYPDLSFVLKVD....S..K...vKFALDLKTTYRNEKNPk......lCNGFTLGSHGQYFKN.R.E.SS.K.NIQFPYNQYLGHF.CLGV..IYDRVLV..--DELQKYELKELDKIQSVIKNLTLFFVEKYKIASDCSGSGNTANIGSI..K.NIDDIINQRGIFAKLG..EE..VFDDYWINYGQIH..IK.DAN-.-.G.SVKK..ITKLKDYLAYR-g..................
A0A4U8SL65_9HELI/20-258              .........................................n-ICQNNTEWKVKGFIDSEKNIFSLSNDTKVISKILEIHIFPYIL.EF.ANANA..FDIVLPNHQNYYPDLSFVLKQD....S..K...iKFAVDLKTTYRNENNPt......lCNGFTLGSHGEYFRN.R.E.SN.K.NIQFPYKDYLGHF.CLGI..IYDRVLV..--NELRQYTLNDLDKIQSVITNLTLFFAEKYKIASDVSGSGNTANIGSI..K.NIDAIINEKGIFAELG..EE..IFNDYWINYGQIN..IT.DSH-.-.G.NIKK..ITKLEEYLKYR-g..................
A0A109CPZ5_9BACT/26-267              .........................................h-VATDDRQWTIKGFIDVFRNVYTISADTKIVSKILEIHLFPVLL.KF.AQKHN..YIIVLADHQNYYPDLSFVSTRD....E..S...iKFAVDIKTTYRLPNKPg......fCNGFTLGSHGSYFIE.R.D.KK.K.NIQYSYNQYCGHF.CIGI..IYTRANI.rDIDETTIQKVEQLQSITSVIRDFEFFACEKWEIASDSQGSGNTANIGSI..V.RIKDILSGNGVLKNLG..EE..WFDEYWMNYGKIM..IT.TET-.-.G.KTKK..ITKLNEFLVFK-g..................
A0A2T6ADP3_9RHOB/48-257              .................................leagghflp-----------------------LPKESAALANIMEVSLVDYLL.EAvSTLND..VELQRGTE-RGYPDLELSGSRF....G..D...rPYAVDVKAARRKVGARgrvnprktQSRITLYTGNTYFKY.P.QlHW.P.NTFRPFQDYEAHL.DIIA..IYTLDES..---------------RPSRIADLELIVQESWKIGSRQRSSTTREYIGAV..D.DIPRLRAGEGDFDT--..EQ..AFYKFWRNYP-FK..IGvSVAK.-.-.----..------------qlekllhqr..........
R2PL54_9ENTE/16-254                  .......................................kid----DKNAWDLLGFVNEKKEVFPFGNDSKIIGRLFEVIVYPYLL.EV.AEELG..YKLFESKKQTVYPDFYFLKPDK....-..K....RIALDIKTTYRQFDKQgq....ikEFNFTAGSFTSYL--.R.N.GT.K.NIDGNYSDYDKHY.ILGF..LYSRNEG..ESIRKVNLESEDISSIVPAYKDVEYFVQEKYKVAGTSKGSGNTDNIGTFksK.IIKDFQDGNGPFSKLG..ND..LFHIYWENFPKYK..--.DSQ-.E.V.KDKL..FNNLETFTEW--gk.................
A5V954_SPHWW/49-249                  .............................agdhflplpkepa-----------------------------ALANIIEVAVVDYVM.EQ.LGQSE..VELVRGTER-GYPDLEM--NAN....G..R....FFAIDVKVARRKVNKR........--GFPTGKTDSRITL.Y.T.GN.T.FFMYPTLKWAGTF.RPF-..--ADYAG..HIDLICLYTLNEGS--AARVTDFELLVVEPWAIASKSRSSTTREYLGAV..D.DIQRLRDSQGEFKSP-..EE..-FYSYWRKHP---..--.----.-.-.----..------------wkigkavqqqlqklla...
A0A1E8Q1V1_9MYCO/47-244              ......................................aggh--------------------ILPLPKEPAALANVLEVGIVSFLM.DR.AADLP..GATAARGTERGYPDVEFGGEAF....G..G...gFHAVDIKVARRAVGARgnp.lprtQSRITLYTGNTYFRHpK.I.SF.P.GVMRPFAEYASHLdVLG-..-------..------IYTLDET--APGRVADLELIVQQPWRIASRHRSSTTREYIGAV..D.KIDDLRAGRGEFDT--..EA..DFYSYWRRYPF--..--.----.-.-.----..------------ktaravel...........
A0A059FE26_9RHOB/11-244              ......................................elek----LADSYKVCGIVDQTGCVYPLGADTKVLSTVFELVSRPAVY.AA.AKALN..YECVEPAVQNHYPDFTFHRGLE....A..G...gKIAIDIKTTYRIHDDD........RFRYTLGGYTSFIRP.G.N.EK.K.SIVFPFDQYSEHW.VIGF..VYNRIAE.kKAQAAHKFGVDQLEDIPLPFGNVEVFVQEKWRISSDRAGSGNTTNIGSI..NgTIDDFRAGNGPFTS--..EE..EFLAYWRAYGRTK..-A.DRSN.F.S.NIAE..FR----------rleq...............
A0A2G5L7H7_9FLAO/22-265              .........................................y-VSDKAGDWKVKGFIDIEKSVYTISSDTKIISKILEIQLFPKFQ.EF.ADQNG..YEIVLAEMQNWYPDLSFVNKAN....P..K...iKFAVDIKTTYRLDDYDg......fCNGFTLGSHGEYFRT.R.T.ST.K.NIQFPYAEYTSHI.CLGI..LYTRALS.tDIDETKILELNNLDKITSVIKDLVFFAEEKWKISSDKGGSGNTANIGSI..Q.YIDDILKGNGVFKNLG..EE..IFDEYWINQGVLQ..VP.DPKK.S.G.NFKK..LTKLTEFLEFK-g..................
R5AHW7_9CLOT/23-263                  ........................................af--IAKGDEWTIRGFIDIFKNIYTISTDTKIVSKVLELHLFPHFL.TF.AENIG..YTIELATYQNWYPDLTFISKAD....P..T...iKFAVDLKTTYRDEECPg......fCNGFTLGSHGEYFIE.R.T.ST.K.NIQYPYDEYCGHF.CLGI..IYSRADI.sKDEETHIYSIDEVERIPAVIRNFLFFAEEKWKIASDKGGSGNTANIGSI..Q.KIDDILNGNGVFAKAG..ED..IFDDYWANFGKIE..IPvDGK-.-.-.-RKK..LSSFEEYLRYR-g..................
R5BH01_9FIRM/18-248                  .........................................q-LESMKYSWNFAGLINFNNTIYPFGNDSKIIGRIFEIAAREALS.MA.AQKLG..YIFQENPTQTVYPDFYFAIPNT....D..K....LIAIDIKTTYRQSSSA........SFKFTAGSFTSYL--.R.N.GT.K.NIVGHYDNYIKHY.IIGF..VYDREES..--PTTQCTHYEDRDSIIPAYKNVEFFVQEKYKIAGEQKGSGNTDNIGTIsaN.SIEPFRLGYGPFSVLG..EE..IFEDYWRHYPKYT..--.DTKK.L.-.----..YTNLPTYIEWKK...................
L7UJD8_MYXSD/12-159                  .......................................avq---RQGVRFKVQGLLGEQERVYTLGTAPRELSALFELYCQPLIV.DI.ADRLG..LRIADAP-RTVYPSFTLMKNEA....D..R...aKVAIDIKTTFRRPEL-........--TFPLGPYTAFS--.R.N.GA.Q.DTRYPLDQYAEHW.VIVF..VYRRDDD.iEWFVQERY-----------------------------------------..-.----------------..--..-------------..--.----.-.-.----..------------rltdavptq..........
I1B2G6_9RHOB/11-244                  .....................................eldkl-----ADSYKVCGIVDQTGCVYPLGADTKVLSTIFELVSRPAVY.AT.AKALG..YECLEPTVQNHYPDFTFHKGLG....E..N...gKIAIDVKTTYRRNDGD........KFGYTLGGYTSFIRP.G.N.ER.K.NIVFPFDQYSEHW.VIGF..VYNRIGT.kKAQAEHSFSLDQLTDIPLPFENVEVFVQEKWRISSDRAGSGNTTNIGSI..NgTIEDFRAGNGPFTD--..ED..EFLAYWRSYGRTK..-A.D---.R.G.DFSN..IGEFRSF-----kq.................
G2PQ61_MURRD/22-265                  .........................................y-VSDKVGDWKVKGFIDIEKSIYTISSDTKIISKILEIQLFPKFQ.EF.ADQNG..YDIVLAEKQNWYPDLSFVNKSN....P..K...iKFAVDIKTTYRLDDYDg......fCNGFTLGSHGEYFRK.R.T.ST.K.NIQFPYADYTAHI.CLGI..LYTRALS.tDIDETKILQLNELDKITSVIKDLVFFAEEKWKISSDKGGSGNTANIGSI..Q.YIDDILKGNGVFKNLG..EK..IFDEYWINQGVLK..VP.DPKK.A.G.NFKK..LTKLTEFLEFK-g..................
R7EWJ3_9BACT/1-95                    ..........................................--------------------------------------------.--.-----..----------------------....-..-....----------------........---MTLGAFTGYFRN.R.Q.ST.K.NVTYPYSSYKAHI.VLGI..IYSENDE..TVDERKIYTIEDLENIVSVVKDITFFVQEKWKIAIDRPESGNTKNIGSV..S.LID-------------..--..-------------..--.----.-.-.----..------------i..................
R5RMA3_9CLOT/12-247                  .........................................k-LEEKDIDWEVSALASPDGKLFSLGSDSKLIGRIFELISYNILQ.EI.ADENG..LILYPSPRQTVYPDFTLMKSEA....D..T...eKIAVDIKTTYRKFLKNgq....psGYVFTLGSFASYM--.R.D.GK.K.NISFPYDQYAKHY.VIGF..VYTRNDN..-ASEGQMFDIKDLGKLPVPYKDVEVFVQEKYKISGDKPGSGNTENIGSFktN.RMEYLENGEGPFSGLG..ID..IYEDYWAGYKKYR..--.----.-.-.----..------------geltytsldgyfdvqe...
F9D0Q7_PREDD/20-249                  .........................................v-LETEDSEWIVKGFIDVGRNIYTMTNDTKVVSKILELILIPRLE.AF.AGRYE..LVLELPSAQNFYPDLTFKDEDG....H..-....LFAVDFKSSYYGDNNR........VNGLTLGSYWGYFRN.R.E.VK.K.NTDYPYKDYQCHL.VIGM..LYRQSPS..LQGERTVYQLDELDRIKSVIEQFVFFVQPKWKIASDRTGSGNTRNIGGV..V.EIDRLVEGTGPFAGLG..EE..VFDHYWMNF--FN..AA.DAAK.A.G.----..------------igspvitis..........
M0QFW5_9ACTN/37-255                  ....................................vvanse--------QELQQLLESTGQIMPLPKESAALANILEVSIVDFIL.GR.VDTVP..GATAERGNERGYPDLEISGEAF....G..G...gFHAVDVKMARRGRTKTgrl.tantQSRVTLYTGNTYFRY.P.S.LH.WpGTFRPFNDYASHLdVLGV..-YT----..---------LNVES--KARVDDLEWIVQPPWKIGSKHRSSTTREYIGAV..K.SVEDLREGQGDFGSPA..E-..-FYTFWRKH-N--..--.----.-.-.----..------------fkigkvvqqqldklln...
E7G3V5_9HELI/7-227                   ..........................................QICQPDHQWKIKGFIDNEKQLFSISNDTKVVSKILEIHMFPYIL.EF.AKNCG..FEVILPSHQNYYPDLSFVSKIN....P..E...iKYAIDLKTTYRNEKNPn......fCNGFTLGSHGEYFRN.R.E.SC.K.NIQFPYKSYSGHF.CLGI..IYDRV--..KVNELERYSLQDLQHIPSVIKNLTLFFAEKYKIASDTSGSGNTANIGSI..K.VIENILHERGIFAEWG..EE..IFDDYWMNYGRIT..--.----.-.-.----..------------kkef...............
A0A0N0AIM2_9ACTN/48-260              .....................................lalgg-------------------HILPLPQESAALANVLEVSIVDFII.AR.LHRIA..GGQASRGSDRGYPDLEITGPAF....G..G...gFHAVDIKCARRAPSGKs......tQSNITLYTGNTYFRH.P.D.LHwP.GVPRPFNDYSSHL.DVIA..IYTLR--..-------------PDLPHRVDDLEIIVQQPWRIASKSRSSNTRQYIGAV..G.KIDDLRAGRGKFKTPQ..E-..-FYAYWRKY-HFA..ISeEVQN.Q.-.----..------------yqkaleatrlelaryka..
A0A081C4V8_9BACT/25-266              .........................................y-VSTDDGQWTIKGFIDIYKNIYTISSDTKIVSKILEIHLFPHIL.KF.AEQYG..YYIVLPEHQNYYPDLSFIDAHD....P..S...iKFAVDLKTTYRLPESSe......fCNGFTLGSHGEYFIQ.R.S.SR.K.NIQFPYSDYLGHY.CLGI..IYSRAAV.hHLDDTATYTLDHLCSIVSAIRDFQFFAVEKWRIASDKSGSGNTANIGSI..N.YIPDLLNGNGMFAQLG..ES..WFDDYWMNYGVIT..MT.DPE-.-.G.TTRK..ITTLEDFVTYR-g..................
A0A109B9Q5_HYPSL/48-250              ................................leagghfial------------------------PKESAALANIVEVSLVDFLM.DC.IGKHN..DISGARGTERGYPDIEITGPRF....G..D...vPHALDVKVARRAKSGNq......tQSRITLYTGNTYFRY.P.Q.VK.WpGTFRPFRDYASHL.DLIA..IYTLNED..-----SRHRID----------DLELIIQPAWRIASKQRSSTTREYLGAV..T.SISDLRAGKGEFES--..EA..AFYAFWRKYP-FK..I-.----.-.-.----..------------gkavqqqldkllas.....
Q7VJK4_HELHP/20-258                  .........................................k-ICQPNHQWKIKGFIDSDTHIFSLSNDTKVISKILEIHIFPYIL.EF.AKTHH..FNVVLPYHQNYYPDLSFVSQKD....S..T...iKYAIDLKTTYRNENNPk......lCNGFTLGSHGEYFKN.R.E.SN.K.NIQFPYKDYLGHF.CLGV..IYDRV--..KIDELKRYKLDDLGKIQSVIQNLTLFFVEKYKIASDCSGSGNTANIGSI..K.NIDDILNEKGVFADLG..ES..LFDDYWINYGKIT..IT.DSQ-.-.G.KTKN..ITKLSEYLTYR-g..................
A0A2M9BBH2_9MICO/22-263              ........................................ys--EQEDGQWTVKGFIDVFKNIYTISADTKIVSKILEIHIFPELL.KF.ADEAG..YQIVLADHQNYYPDISFVALDD....P..T...iKFAVDLKTTYRLQDKPg......yCNGFTLGSHGAYFVD.R.A.GK.K.NIQFPYNEYTAHY.CLGV..IYDRALK.tDLDETRVYDITDLESITSVISHLQFFLTEKWKIASDKSGSGNTANIGSI..N.NVEEIVAGAGMFSRLG..ES..WFDDYWMNYGKIS..IS.LPT-.-.G.VTKK..ITDLESFLVYR-g..................
A0A251X955_9GAMM/4-76                .......................................lil---------------------------------VLEIHLFPKLM.EF.AKKYK..YKIVLADHQNYYPDLSFVKSDN....E..D...iKFAVDFKTTYRLSDKPy......lCNGFTW---------.-.-.--.-.-------------.----..-------..-------------------------------------------------..-.----------------..--..-------------..--.----.-.-.----..------------lsw................
A0A3A9EFW6_9FIRM/11-242              .....................................kemqn------INFETYGILDSSGMIHTLGTDSKIIGRIFEMFTQPILE.KI.AKRHN..MILTTPASQTVYPDFIMMNEIN....P..K...gKIAIDIKTTYIESDHS........TIKFTLGSFGSYM--.R.N.NT.K.NIEYKYTDYSKHY.VVGF..VYKRNGR..-AQESKVYEYKDRDKIIFPFYDVKYFIQEKYKIAGDKPGSGNTENIGSFttK.NLDDLKDGKGPFRELG..PD..AFDLYWKYYPKYR..TT.N---.-.-.--KP..YTSLMEFVKW--fp.................
A0A1X1R392_9MYCO/49-254              ....................................ladggh--------------------ILPLPQEPAALANVLEVSLVDFLS.ER.ADAAD..GVSVLRGTERGYPDLELSGPRF....G..G...gFHAVDVKVAKRKITKTgkp.tnltQSRITLYTGNTYFRY.P.Q.LH.WpGTFRPFNDYTSHL.DLIG..IYTLNYI..--------S-------LARIEELELLVHEPWRIASKQRSSTTREYIGAV..Q.HIDALREGRGEFSS--..PE..AFYAFWRKY-NFR..--.----.-.-.----..------------igkvvqqqldkll......
A0A222EAQ4_9RHOB/22-265              .........................................y-VSTNGGDWSIKGFIDVDQNIYTISADTKIISKILEIQLFPKFL.EF.ADAAG..YDLVLAEHQNWYPDISFVKKSD....P..S...vKFAVDIKTTYRLSEYKd......fCNGFTLGSHGAYFRD.R.A.ST.K.NIQFPYKDYNAHI.SLGI..LYTRALS.dDIDETEVRDLSELTSITSVITDLLFFVEEKWKIASDRSGSGNTANIGSI..S.YIPDVLAGNGAFANLG..ED..VFDEYWINQGVLQ..VP.DPKN.P.K.KFKN..LTKLSEYLEFK-g..................
W0F5I3_9BACT/20-257                  .........................................v-IATEKGDWIVKGFIDIYKNVYTISIDTKVVSKVMEILLIPAFE.KF.AQKND..LKLELPPQQNFYPDLTFTCNKT....G..E....RFAVDIKSTFKDSTNK........IKSMTLGAFTGYFRN.R.K.ST.K.NTLYPYGSYSAHL.VLGV..IYSQIEE..NPNEKTIYSIDELDKIESVIKDFHFFVQPKYKIASASPGSGNTKNIGST..N.SIDKLIKGNGVFSTLG..EE..VYDDYWIYF----..LTkDMAK.A.L.EIPR.pYTNLKSYLEYKQ...................
A0A1Q2SL26_9GAMM/1-48                .........................................m--------------------------------------------.--.-----..----------------------....-..-....----------------........---------------.-.-.--.-.-------------.----..-------..-------------------------------------------------..-.------AGRGIFSKLG..ED..WFDKYWMSYKKII..VQ.DGK-.-.G.GTKK..IATLREFVEYK-h..................
A0A377PWD4_9HELI/1-210               ..........................................-----------------------------MISKILEIHLFPYIL.AF.AKANS..FEVILPSHQNYYPDLSFVSKQD....S..N...iKFAVDLKTTYRNESNPn......lCNGFTLGSHGEYFKN.R.E.SN.K.NIQFPYKQYQGHF.CLGV..IYDRVL-..-INEFVRYGINDLKKIPSVIQNLTLFFVEKYKIASDSSGSGNTANIGSI..K.NIDDIINEKGIFANLG..EE..IFDDYWINYGQIN..IT.DSK-.-.G.NIKK..ITKLKEYLAYR-g..................
D3IKT3_9BACT/20-257                  ........................................ll--ETPNNDWIVKGFIDVNKNIYGITNDTKVVSKVIEIILIPKLA.SF.AERNG..LVLEFPSAQNFYPDLTFKDKEG....N..-....LFAVDFKSSYYRDDKK........VNGLTLGSYWGYFRD.R.Q.VK.R.NTDYPYDDYKCHL.VLGV..LYKQGVE..DGKDMEVYSIDTLADIKSVIEHFIFFVQPKWKIASDQPGSGNTRNIGGV..V.DVDKLVNGEGTFAKYG..EE..VFNDYWMNY--YN..AA.DAQK.A.G.MGKQ.hYHNLKTYIEY--le.................
A0A090IN15_9GAMM/16-259              .......................................qlt----EHCSWEVQGFVDMNNNVLPIDSDSKVLSTVFERFASPALR.SL.AAEFG..YVVETA-NQTTYPDFTLTKYGM....N..GcvihRIALDIKSTYIEAKYHnpq..efkKTKMTLGSYNSFI--.R.N.NT.K.NILYPYSTYHEHW.VLGF..VYFRNAA..-FEEYTLENLPQRGDIYCPYSVESIFIREKVDLTGIRAGSGNTKNIGSVdiS.YPRGFEYVNGPFTQFHhkKQ..ACDYYWTNYEELKfdIT.DSDS.L.Y.----..------------dhpemvqfr..........
A0A1A3JKE7_9MYCO/49-257              .................................laqmlaegg-------------------HILPLPQEPAALANVLEVSLVNFLL.ER.GNRTE..GVTVLRGTERGYPDLELSGPRF....G..G...gFHAVDVKVARRKVTKAgrp.tnstQSRITLYTGNTYFRY.P.Q.LH.WpGTFRPFQDYTSHL.DLIC..VYTLNY-..----TSLAR----------VEDAELIVQEAWRIASKQRSSTTREYIGAV..Q.KIDALREGQGEFDS--..PE..SFYKYWRKYP---..--.----.-.-.----..------------fkigrvvqqqldkl.....
R7J2P1_9BACT/1-96                    .........................................m--------------------------------------------.--.-----..----------------------....-..-....----------------........---------------.-.-.--.-.-------------.----..-------..---------VDELARIQSVIEKFVLFVQPKWKIANDIPGSGNTRNIGGV..S.NIQQLINGQGPFADLG..ED..VFDDYWQGY-FNK..-V.DARTaG.I.GTPR..YNNLKSYKEY--lk.................
A0A1H6K708_9GAMM/20-261              .........................................y-ISTEDGQWTIKGFIDVFQNIYTISSDTKIVSKILEIHLFPKIM.EF.AQKHG..YKVVLAEHQNYYPDISFVKSDD....T..S...vKFAVDFKTTYRNPKKSf......lCNGFTLGSHGKYFED.R.T.ST.K.NIQFPYSEYAGHF.CLGI..IYDRAKG.sSIDETKSHNIEALHSITSVVSNFQFFVTEKWKIASDKSGSGNTANIGSI..N.NIDDIINGRGVFSKLG..ES..WFDDYWMNYEKIT..IS.DK--.N.R.ETKK..ITSLKDFVDYRK...................
A0A369QWQ1_9RHOB/11-245              .....................................emdkl-----ADSYAVCGIVDQAGSVYPLGADTKVLSTIFELVSRPAVY.AA.AKVLG..YEVVEPTVQNHYPDFTFHRGLG....D..N...gKIAIDVKTTYRMHDDD........KFSYTLGGYTSFIRP.G.N.EK.K.NIVFPFPEYSEHW.VLGF..VYNRIAE.kKAGAEHQYTIDRIGEIPLPFENVEVFVQEKWRISSDRAGSGNTTNIGSI.hA.TIDDFRAGNGPFAS--..ED..EFLDYWRSYGRTK..-A.----.-.-.DRSD..FSNIHEFRAFK-kr.................
A0A255Z9I3_9FLAO/178-287             ........................................ee--------------------------------------------.--.-----..----------------------....-..-....----------------........---------------.-.-.--.-.-------------.----..-YETPNK..KVGERSVTTVKNLKSITSVIKDFDFFAAEKWKIASDKQGSGNTANIGSI..F.DIEDLKNENGIFSKLG..EE..WFDEYWINHGSAT..--.-MVK.D.G.KPTK..ITTLKDFLEFK-g..................
R5APG6_9BACT/20-257                  .........................................l-VSTKDGQWVVKGFIDVYRHIYTISTDTKVVSKIIELYIFPLLF.KF.AQDNG..LQLELAKEQNFYPDITFKDEDG....N..-....LFAVDLKSSYRKTADR........INGMTLGAFTGYFRN.R.R.SS.K.NVTYPYSSYKAHI.VLGI..IYSENDA..AIDERKLYTLDDLDDIVSVVKDITFFVQEKWKIAIDRPGSGNTKNIGSV..S.LIEDLIYGNGPFSELG..EA..IFDDYWTNY----..LTsDMAK.K.A.ELASpyYNNLGSYKKFR-n..................
A0A2H5WS21_9BACT/32-271              .......................................lls---GQGRDWAIRGVIDTFQQIYALSADTKLISKIMEIVLLPHML.QF.AQKHK..YKTVLSPKQNYYPDITFIDDTP....H..R...hKFALDIKSAYRLSDTE........VSMMTLGAFTGYFRN.R.R.SR.K.NITLPYEEYSAHF.VLGI..IYTRNDS..SINRSRAYALKELNSIPAVISDILLFVQYKYKITSDKPGSGNTKNIGAI..T.RIEDLVKGRGPFAELG..EE..VFDDYWMHY--LT..-T.DMAR.A.E.GLEKppYSDLESYQRYKQ...................
R4TMS2_9VIRU/10-197                  ......................................lfde------FEWDIEGILHTNGLVSDVPRTSNPVTAIVEELAIQKIE.L-.----V..HDIERPDHSRQYPDITFNSN--....-..E....RVALDIKTAQMKNADS.......lEGGVTLGTCKSYFSS.PdD.DS.P.WIKYPYNSYDEHW.VLLF..AYQWE--..--PEAKTIDMVSIEDI---------IINEKWKMASRSNGSGTTNNIGSS..Q.KLDLIRGDNSVFSS--..EA..EFENFWR------..--.----.-.-.----..------------q..................
A0A139SQA4_9GAMM/25-266              .........................................y-ISSSDGQWSVKGFIDLYKNIYTISHDTKIISKILEIHIFPKLL.DF.AKKHG..YKMVLAEHQNYYPDISFITDGE....N..P...kRFAVDFKTTYRRADKPh......lCNGFTLGSHGKYFEE.R.T.ST.K.NIQFPYGSYSGHY.CLGI..IYDRIGE.sQIDETKIFTMDALSSIASVAGNFQIFFVEKWRIASDKSGSGNTANIGSI..N.NIADIVKGNGMFAKLG..EK..WFDDYWMNYRKIT..IA.DEN-.-.G.ETRK..ISKLKDFVKYRK...................
R9M6W0_9FIRM/11-241                  ....................................ekmegv-------NFEAYGILDSDNRIHTLGTDSKIIGRIFEMFTQPILS.EI.AQAHG..MLLKTPVSQTVYPDFIMMRDEA....S..R...eKIAIDVKTTYVGGNQS........TIKFTLGSYGSYM--.R.N.NT.K.NIEYLYTDYVKHY.VIGF..VYRRNGA..-AQESAVYDYSRRDQVVFPYRDVRYFIQEKYRIAGDKPGSGNTENIGSFptR.CFSDLREGRGPFGELG..VD..AFDLYWKYYPKYR..SP.E---.-.-.--KA..YTTLDGFLEW--v..................
I4F1M5_9ACTN/33-237                  hllplpkepaalanvievdivdfllarlqllpdaeyqrgser--------------------------------------------.--.-----..----------GYPDLEVGGRAF....G..G...aWHAIDVKVAQRARRSA........AAR--PGT-----TE.R.T.QS.R.ITLYTGNTYFRHP.TLHWpgTFRPFDD..YRSHADVIVIYTLTDSASRVADLEVIIQEPWRVGSSKRSSTTREYIGAV..D.GLDDLRAGRGEFATA-..ED..-FYRFWRRFPFR-..--.----.-.-.----..------------tspgvqriyerlvae....
S0ITX6_9FIRM/12-248                  ......................................ktge----RNISWEIKALVTPEGNVYTLGSDSKLIGRIFELISYEIIK.EI.ADENE..LLLLPSDRQTVYPDFTLMKDER....D..E...rKIAIDIKSTYRLSGEDrk....skLFNFTLGSYASFM--.R.N.GT.K.NIMFPYAQYAKHY.VIAF..IYTRNER..-ASEGEKHHISELQTLQVPYKDVEVFVQEKYKISGEKPGSGNTENIGSYktD.KMDYLINGEGPFSVLG..LE..IFEEYWAGYPKYR..--.----.-.A.EKKN..YTSLEEYFEW--ce.................
A0A1J0AAT7_9CYAN/20-257              .........................................a-VATNEGDWIIKGFIDVYRRIYTISIDTKVISKVLELLLFPLFM.DF.ARQQK..LEIELSPQQNFYPDLTFIEKET....G..N....KFAVDIKSTYRTDHDQ........VNGMTLGAFTGYFRN.R.N.SN.K.NTLYPYGEYQGHF.VLGV..IYTKTDE..ATDERKQYKVDDLEKIPSVLKEFQFFVQPKYRIASDRPGSGNTKNIGSA..V.KIPTLINGEGSFSKLG..EE..VYDDYWMFY----..LTnDMAK.A.L.DIER.pYTNLKTYLAYKQ...................
A0A495D831_9ALTE/21-262              .........................................y-ISSEDGQWTIKGFIDIFKNVYTISSDTKIISKILEIHIFPKLL.EL.SEKHG..YKIVLADHQNYYPDISFVDNDN....N..S...vRFAVDFKTTYRQPKKPh......lCNGFTLGSHGKYFED.R.T.ST.K.NIQFPYGTYSGHY.CLGI..IYDRVDS.rDIDETKIYDLDSLKSITSVVGNFQFFVAEKWKIASDKSGSGNTANIGSI..N.NIADIIKGKGVFSKLG..EE..WFDDYWMNYKKIT..IP.DGNK.G.-.-TKK..ITNLKDFVKYRK...................
A0A495KNK5_9FLAO/207-315             ..................................sygdtvdp--------------------------------------------.--.-----..----------------------....-..-....----------------........---------------.-.-.--.-.-------------.----..-------..-IGERKVTQIKNLKSITSVIKDFDFFASPKWKIASDSQGSGNTANIGSI..K.DIDDLKNGNGVFSQLG..EE..WFDEYWVNYGTAT..--.-MIK.D.G.NSIK..ISSIWEFLEFK-g..................
V2RL55_9BACT/20-257                  .........................................y-VSDESKNWTIKGFIDVYKNIFTISTDTKIISKILEIHIFPIIS.RF.AFEKG..FNLVLADHQNYYPDMSFVFIEN....P..S...iKYAVDIKTTYRKSDNK........CNGFTLGSHGEYFIN.R.A.SS.K.NIQYPYNEYKAHY.CLGI..IYSRNYI..-VDEINMFNINELYTIESVIKNIEFFFIEKWKIASDKSGSGNTANIGSI..T.KIQDIINGNGVFKDYG..EE..MFDAYWMNYNKIT..IT.TND-.-.G.RTKK..ISTLKEYLKY--ig.................
A0A495KNK5_9FLAO/55-213              .........................................y-VSTETGEWTIKGFIDVYKNIYTISSDTKIVSKILEIHIFPEIL.RF.AEKSG..YKIILAEHQNWYPDLTFVNIKN....D..N...iKFALDLKTTFRRNH-T........SAGFTLGSHGGYFKE.R.D.KE.K.NIQFPYNKYTGHY.CLGV..IYTRSDFddDLSDTEIFQVKDMEE----------------------------------..-.----------------..--..-------------..--.----.-.-.----..------------sygdtvd............
A0A0F0H835_NOCAE/16-239              ...................................iaassad---------QLEGLLHEHDHLLPLPKEPAALANILEVSIVDYLL.TR.LDATE..GAEHTRGTERGYPDLEISGPAF....G..G...sYHAVDVKVARRGDTNKs.....ktQSRITLYTGNTYFKW.P.D.LHwP.GTMRTFNDYRSHL.DIII..IYTLD-S..--D------------SKARVQDMEIIVQQPWKIASKQRSSTTREYLGAV..E.SIAALRDGRGEFSTPA..E-..-FYRFWRAYP-FK..ISaQVQK.Q.-.----..------------larlvqkqqqeieql....
A0A091FGK0_9DELT/9-246               .........................................a-ISTNSGDWVVKGFIDIAKNIYTISVDTKVVSKIMELLLFPKIC.HF.AQEYG..YKMFLCKEQNFYPDVSFIDADN....N..-....IYAVDLKSTYRKNEKE........VNGMTLGAFTGYFRD.R.K.ST.K.NISYAYEKYTGHF.VLGV..IYSRTDG..DVDEKKVYQLSDLQNITSVICDFKFFVQEKYRIALDRPGSGNTKNIGSV..I.KIDDLVKGQGPFANLG..ED..MFDDYWMYY----..LTkDMAK.S.I.DLKNapYKNLKEYKEYK-g..................
A0A251X9H2_9GAMM/7-98                ...............................idfqinhifat--------------------------------------------.--.-----..----------------------....-..-....----------------........---ALLGSHGKYFQD.R.T.ST.K.NIQFPYGSYSGHF.CLGI..IYNRADE.gVIDETQKYTVGELHSIASVVRDFQFFAVEKWKIASDKS-----------..-.----------------..--..-------------..--.----.-.-.----..------------r..................
A0A255Z9I3_9FLAO/27-182              .........................................y-VSTDNGDWTVKGFIDVYKNIYTISSDTKIVSKILEIHIFPQIL.QF.ADSIG..YKIILAEKQNWYPDLTFVKKDN....E..E...vKFALDIKTTFRRNDK-........TAGFTLGSHGGYFKE.R.D.KD.K.NIQFPYNQYTGHY.CLGV..IYTRTDVsdDLAETEIYQVQELQ-----------------------------------..-.----------------..--..-------------..--.----.-.-.----..------------eeyet..............
A0A316E928_9BACT/27-268              .........................................y-VTTPDNQWTIKGFIDVFENIYTISNDTKIVSKILEIQLFSKFV.EF.AQQND..FRLVLAEKQNWYPDVSFVSKND....S..S...iKFAVDLKTTYRTEENPq......fCNGFTLGSHGAYFTE.R.T.SS.K.NIQFPYNDYLGHY.CLGI..IYTRTIL.gENFESITFPLNQLNTIPSVIGNMTFFACEKWTIASDKGGSGNTANIGSI..N.NIEDILAGHGTFKHLG..EE..WFDEYWMNFGKII..IK.DEN-.-.G.NTKK..LTSLKEFLKYR-g..................
C3J9L6_POREA/20-256                  ........................................fl--ETDSQDWIVKGFIDVDKNVYTITNDTKVVSKIIEILLIPKLD.SF.ARRNE..MRLELPSKQNFYPDLTFKDSEE....H..-....LFAVDFKSSYYDGE-N........VNGLTLGSYWGYFRE.R.D.SI.K.NMDYPYNAYSSHL.VLGM..LYKQSQL..QVDECEVYSVDDLHTIHSVIENFIFFVQPKWKIANDIPGSGNTRNIGGI..T.NIQNLLEGKGPFSELG..EE..VFDDYWKGY--FN..KV.DART.AgI.GTPN..YKNLKTYKEY--le.................
R7J2H7_9BACT/20-147                  .........................................y-LETDNRDWIVKGFIDIDKNVYTITNDTKIVSKIIELLLIPKLN.KF.ALEHN..MVLELPSKQNFYPDMTFIDEDG....H..-....LFAVDFKSSYYCG-EF........VNGLTLGSYWGYFRE.R.D.AI.K.SMDHTYNSYSSHI.VLGI..LY-----..-------------------------------------------------..-.----------------..--..-------------..--.----.-.-.----..------------...................
R6C8U6_9CLOT/24-263                  .......................................ris----TGDDWNIRGFIDIFKNIYMISSDTKIISKVLELHLFPHFL.SF.ANSIG..YDVELATFQNWYPDLTFICKKN....R..N...iKFAVDLKTTYRDNNYPg......fCNGFTLGSHGEYFIN.R.T.ST.K.NIQYPYDDYSAHF.CLGI..IYSRTSL.dKNEETHIYSLDEIEHIPAVITNFLFFAEEKWKIASDKGGSGNTANIGSI..Q.KIEDIVNGNGVFAKAG..EE..LFDDYWINFGKIE..VL.V---.N.G.KRKK..LSSFEEYLQYR-g..................
D0KWR7_HALNC/21-262                  .........................................y-ISSEDGQWTIKGFVDMYKNIYTISSDTKIISKILEIHIFPKLL.EL.SEKHG..YKIVLADHQNYYPDISFVDNDD....D..S...vRFAVDFKTTYRQPSKPh......lCNGFTLGSHGKYFED.R.T.ST.K.NIQFPYGSYSGHY.CLGI..IYDRVDS.rDIDETKIYSLDSLTSITSVVGKFSFFVAEKWRIASDKSGSGNTANIGSI..N.NIADIIEGKGMFSNLG..EE..WFDDYWMNYKKIT..VP.DGK-.-.G.GTKK..ITNLKEFVAYRK...................
A0A401G309_9DELT/17-78               ........................................li--------------------------------------------.--.-----..----------------------....-..-....----------------........---------------.-.-.--.-.-------------.----..-------..-------------------------------------------QNIEYV..A.SASDILKQKGMFSELG..EK..WFDDDWMNFRRIT..VT.DEN-.-.G.KPSE..ISSLKDFVEYR-g..................
A0A401G4I6_9DELT/21-262              .........................................h-ISMDDGQWTVKGFIDVFKNIYTISSDTKIVSKILEIHLFPEIL.KF.AEKSG..YKLVLAEHQNYYPDISFVKADD....D..S...vKFAVDFKTTYCKPDNPe......vCNGFTLGSHGEYFRN.R.K.ST.K.NIQFPYSEYQGHF.CLGI..IYDRTNG.sTIDETKSYGIEELRSIASVVRNFRFFVAEKWKIASDKGGSGNTANIGSI..N.NISDILEQKGMFSKLG..EQ..WFDDYWKNYKRIT..IE.DEK-.-.G.DSQQ..ISSLKDFVEYKK...................
A0A095Y7K5_9BACT/20-257              .........................................l-LETKDNEWIVKGFIDVNKNVYAITNDTKVVSKIIEIILIPQLE.FF.AKRHG..LAMEFPSAQNFYPDITFRDEDG....N..-....LFAVDFKSSYYGDDKR........VNGLTLGSYWGYFRN.R.D.VK.R.NTDYPYGDYKCHL.VLGM..LYKQSAV..ERNQKEVYGIDELDAIKSVIGRLVFFVQPKWKIACDRPGSGNTRNIGGV..V.NIDKLINGEGPFAELG..EE..VFDHYWMNFDNAA..--.DAKT.A.GlDKPR..YNNLKTYQEY--lk.................
A0A1X1QRW9_9GAMM/20-261              .........................................h-ISTEDGQWTVKGFIDVFQNIYTISSDTKIVSKILEIHLFPKIM.EF.AEKHG..YKIVLAEHQNYYPDISFVKAED....K..S...iRFAVDFKTTYRNPSKPy......lCNGFTLGSHGKYFEE.R.T.ST.K.NIQFPYGEYSGHF.CLGI..IYDRADG.aSIDETASHNIKDLHSIASVVSGFQFFVAEKWRIASDKSGSGNTANIGSI..N.NIEDVISGNGMFSKLG..ES..WFDDYWMNYNKIT..IP.DGK-.-.D.GTKK..ITSLADFVEYRK...................
A0A1Q8CRU8_9PSEU/48-253              ...............................ghllplpkepa-----------------------------ALANVLEVSIVDFVLaAV.AEEDG..AEGQR-GTERGYPDIEISGSKF....G..G...gFHAVDVKVARRKINKNgap.sgqtQSRITLYTGNTYFRY.P.T.LK.WpGTFRPFNEYKSH-.----..-------..-LDIIGIYTLDEQSA--ARVVDLELIVQPPWKIASKKRSSTTREYLGAV..M.GITDLREGRGEFDTP-..EE..-FYTYWRKY-KFK..IG.DVVQ.K.-.----..------------qldkllqahd.........
A0A347WNW4_9LACT/15-248              .......................................hlp---TTEEEWELVGFVNKKDDIYTFGNDSKILGRLFEVITFDALE.KS.ANELG..FQLGMSEKQTVYPDYYFFDSIG....N..-....KIGIDVKTTYRRSEKA........KFGFTGGSFTSFM--.R.N.GT.K.NIVGHYDDYKAHY.ILGV..VYVREEK..--PTHGRVKLDKRTGIIPAYKDVEVFVQEKFRICGDKKGSGNTDNIGTIkaS.NIQPFVYGAGPFSYLG..ED..VFNHYWTNHPRYT..--.DSK-.E.V.RDSL..FTDLSSYISW--ir.................
A0A1Q2SL21_9GAMM/22-184              .........................................h-ISTEDGQWTVKGFIDIFKNIYTLSSDTKIVSKILELHLFPKIL.KF.AQENGygYKVVLAEHQNYYPDISFVKAID....E..T...vRFAIDFKTTYRNPKKPh......lCNGFTLGSHGEYFEN.R.T.ST.K.NIQFPYGSYLGHF.CLGI..IYDRANG.aTIDETKSHSIDELQAIASVAKN---------------------------..-.----------------..--..-------------..--.----.-.-.----..------------...................
A0A146G3S4_TERSA/191-305             .............................plggvleeddhkr--------------------------------------------.--.-----..----------------------....-..-....----------------........---------------.-.-.--.-.-------------.----..-------..RTFELKLKKVNRLQSIASVVRDFEFFACEKWELASDRAGSGNTANIGGI..Q.SIEDIKTGNGVFVNLG..EE..IFDEYWMNHGKLK..IL.---K.E.G.KEKA..ITKLDEYLIHR-n..................
B0JX72_MICAN/20-257                  .........................................t-VSTNEGEWIIKGFIDIHKKVYTISIDTKIISKILELLLFPIFD.NF.ARCNQ..LKIELVSQQNFYPDLTFIHEPT....G..A....KFAVDIKSTYRKNNQE........VNGMTLGTFTGYFRQ.R.N.SC.K.NIKYPYQEYSGHY.VLGV..IYTKCDL..VADERKSFRLEDIEKIPSVIKDFQFFAQPKYKIASSSPGSGNTKNIGSV..T.KISELIEGKGIFSLLG..EE..VYDDYWMYY--LT..-T.DMAK.Q.V.DSSR.pYTNLKSYLEYKQ...................
A0A1T4UEB9_9GAMM/17-258              ........................................lt----RNFTWEIQGFIDQNNNVLPIDSDTKVLSTVFERFASPALR.SL.AAEKG..YVVETA-NQTTYPDFTLTKYDV....DgrTv.lhRIALDIKSTYIEPKAPig....ykKTKMTLGSYNSFI--.R.N.NT.K.NILYPYNTYHEHW.VLGF..VYIRNEA..-FEEYTLENIPTRGQIRCPYSVQSVFIREKVDLTGIRAGSGNTKNIGSVeiD.TPNGFAAVNGPFTQFR..NKkgACDFYWANYERLK..--.D---.-.-.----..------------ainspatlynhpemaafk.
#=GC seq_cons                        .........................................h.....t.pWtlpGhl-..pplaslssDoKllo+IhElhlhPhlh.ph.Appts..htlhhstpQshYPDloFhppps....s..p....+aAlDlKoTYRpspp.........psshTLGoassYFp..R.s.sp.K.NIpaPYspYpuHa.sLGh..lYsRs.....hsEtphaslscLppI.uslpshphFlpEKa+IASDpsGSGNTtNIGol..p.pIpclhpGpG.FuphG..E-..hF-cYWhsY..hp.....p..............hpph.pa..a..h..................
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