GenomeNet

Database: Pfam
Entry: Endonuc-FokI_C
LinkDB: Endonuc-FokI_C
Original site: Endonuc-FokI_C 
#=GF ID   Endonuc-FokI_C
#=GF AC   PF09254.13
#=GF DE   Restriction endonuclease FokI, C terminal
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   pdb_2fok
#=GF GA   25.00 25.00;
#=GF TC   25.10 25.30;
#=GF NC   24.70 23.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   FokI
#=GF CL   CL0236
#=GF RN   [1]
#=GF RM   9724743
#=GF RT   Structure of FokI has implications for DNA cleavage. 
#=GF RA   Wah DA, Bitinaite J, Schildkraut I, Aggarwal AK; 
#=GF RL   Proc Natl Acad Sci U S A. 1998;95:10564-10569.
#=GF RN   [2]
#=GF RM   22638584
#=GF RT   Sequence, structure and functional diversity of PD-(D/E)XK
#=GF RT   phosphodiesterase superfamily.
#=GF RA   Steczkiewicz K, Muszewska A, Knizewski L, Rychlewski L, Ginalski
#=GF RA   K;
#=GF RL   Nucleic Acids Res. 2012;40:7016-7045.
#=GF DR   INTERPRO; IPR015334;
#=GF DR   SCOP; 2fok; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Members of this family are predominantly found in prokaryotic
#=GF CC   restriction endonuclease FokI, and adopt a structure consisting
#=GF CC   of an alpha/beta/alpha core containing a five-stranded
#=GF CC   beta-sheet. They recognise the double-stranded DNA sequence
#=GF CC   5'-GGATG-3' and cleave DNA phosphodiester groups 9 base pairs
#=GF CC   away on this strand and 13 base pairs away on the complementary
#=GF CC   strand [1].
#=GF SQ   61
#=GS A0A368YU04_9FIRM/381-557  AC A0A368YU04.1
#=GS A0A4T9WFP4_9FIRM/353-511  AC A0A4T9WFP4.1
#=GS I0X5M2_9SPIO/1-52         AC I0X5M2.1
#=GS G8PBE9_PEDCP/434-626      AC G8PBE9.1
#=GS A0A2C1JY71_9BACI/346-503  AC A0A2C1JY71.1
#=GS A0A174M7L2_9CLOT/384-570  AC A0A174M7L2.1
#=GS A0A3D9KY00_9BACT/253-432  AC A0A3D9KY00.1
#=GS R4KJN4_9FIRM/354-509      AC R4KJN4.1
#=GS A3DG90_HUNT2/353-511      AC A3DG90.1
#=GS A0A1H6V5X4_9FIRM/353-512  AC A0A1H6V5X4.1
#=GS A0A1G4FI67_9FIRM/347-528  AC A0A1G4FI67.1
#=GS A0A137SQ27_9FIRM/380-565  AC A0A137SQ27.1
#=GS A0A0D4CKH1_LACMC/394-582  AC A0A0D4CKH1.1
#=GS A0A0F2J3F6_9BACT/386-573  AC A0A0F2J3F6.1
#=GS A0A1H9CRR6_9FLAO/267-430  AC A0A1H9CRR6.1
#=GS A0A370GG05_9BACI/339-509  AC A0A370GG05.1
#=GS A0A3E2NAJ0_9CLOT/385-571  AC A0A3E2NAJ0.1
#=GS A0A0L8F1Z2_9CLOT/353-511  AC A0A0L8F1Z2.1
#=GS A0A261EPN2_9BIFI/357-517  AC A0A261EPN2.1
#=GS A0A1Q2MCL2_9BACT/389-442  AC A0A1Q2MCL2.1
#=GS A0A419T8E6_9FIRM/385-571  AC A0A419T8E6.1
#=GS A0A1Q2MCG4_9BACT/7-145    AC A0A1Q2MCG4.1
#=GS A0A1G7YEM4_9MICO/328-494  AC A0A1G7YEM4.1
#=GS A0A371AUI5_9FIRM/357-517  AC A0A371AUI5.1
#=GS E7MMY8_9FIRM/18-118       AC E7MMY8.1
#=GS A0A1T4XBI7_9CLOT/353-511  AC A0A1T4XBI7.1
#=GS A0A1Y4GEU6_9BACT/395-585  AC A0A1Y4GEU6.1
#=GS A0A5J6PML6_9BACI/351-509  AC A0A5J6PML6.1
#=GS A0A1Y1RMG1_9MICC/398-585  AC A0A1Y1RMG1.1
#=GS G5IJL9_9CLOT/353-511      AC G5IJL9.1
#=GS A0A1C7G2F5_9FIRM/353-511  AC A0A1C7G2F5.1
#=GS T0SG46_9PROT/352-517      AC T0SG46.1
#=GS E0NM75_9FIRM/380-566      AC E0NM75.1
#=GS A0A1Y4GKR9_9BACT/395-585  AC A0A1Y4GKR9.1
#=GS A0A367XT96_9MICO/336-508  AC A0A367XT96.1
#=GS A0A1D3TWI2_9FIRM/353-511  AC A0A1D3TWI2.1
#=GS A0A1M6KKE2_9FIRM/357-511  AC A0A1M6KKE2.1
#=GS A0A1C0BUS6_9FIRM/388-576  AC A0A1C0BUS6.1
#=GS A0A172Q519_9STRE/387-574  AC A0A172Q519.1
#=GS A0A1M7IV76_9FIRM/395-587  AC A0A1M7IV76.1
#=GS A0A1K1PVB9_RUMFL/386-572  AC A0A1K1PVB9.1
#=GS A0A1N6XYH3_9SPIO/344-499  AC A0A1N6XYH3.1
#=GS A0A1I6BRX5_9BACI/393-582  AC A0A1I6BRX5.1
#=GS V9H5A9_9CLOT/392-582      AC V9H5A9.1
#=GS R9JR57_9FIRM/383-569      AC R9JR57.1
#=GS A0A0R1ZT34_9LACO/433-626  AC A0A0R1ZT34.1
#=GS I3IKA7_9BACT/89-269       AC I3IKA7.1
#=GS U2NP01_9CLOT/353-511      AC U2NP01.1
#=GS A0A1V4I7R7_9FIRM/392-581  AC A0A1V4I7R7.1
#=GS A0A1M4XXY2_9BACT/274-435  AC A0A1M4XXY2.1
#=GS A0A1G4G8X3_9BACT/269-435  AC A0A1G4G8X3.1
#=GS A0A1I0RBP4_9FIRM/354-513  AC A0A1I0RBP4.1
#=GS A0A1P8UD22_9MICO/360-517  AC A0A1P8UD22.1
#=GS R6AWC6_9BACT/400-587      AC R6AWC6.1
#=GS C6JKY8_FUSVA/380-565      AC C6JKY8.1
#=GS A0A017RUA6_9CLOT/353-511  AC A0A017RUA6.1
#=GS R6MYT0_9CLOT/396-586      AC R6MYT0.1
#=GS I3DCT9_9PAST/386-573      AC I3DCT9.1
#=GS A0A1I5VQT4_9FIRM/350-510  AC A0A1I5VQT4.1
#=GS D9R4Y5_CLOSW/385-571      AC D9R4Y5.1
#=GS A0A0V8JLM2_9BACI/393-582  AC A0A0V8JLM2.1
A0A368YU04_9FIRM/381-557             ..............ksrtqyssa---------DINQALKNVPQpdlNYFAedFISLGGNGDKN-....LEFEK.-ANSILFKKLGFETEHIG.pH..G...RN..PDVL......VK.........R.G....GEI..IgIIDAKATSNEYS..I.TSGDERA.V.I.EYINMYNEEEKLK------------..-..-..-.-F...FLFSAGRTAAVSDSNIENIYKST.GVKGS.IISSVLLT.SILKEQLK.AERDLPELE---.-----elfqlnre...............................................................
A0A4T9WFP4_9FIRM/353-511             ..................fmtey--------------------...----..-FEMAFKGRDEA....SDFEK.ATVELFQNVFGFEAKHVG..P.iG...LT..PDVL......IL.........S.D....TDGyqA.IIDNKAYSK-YT..I.SNDHHNR.MvH.NYIKDLNR-YS-----------SYT..V..P..L.AF...FSYIAGGFGKNINSQVMDIVNVT.KVSGS.AISVSNMI.KLVELYEQ.KNYTNKKIRDVF.SVNR-q......................................................................
I0X5M2_9SPIO/1-52                    ......................m--------------------...----..------------....-----.------------------..-..-...--..----......--.........-.-....---..-.----KAYSGGYN..L.PIAQQDE.M.K.LYISNNQKRDEKINSTKWWLEFPDY..L..K..K.--...-----------------------.-----.--------.--------.------------.-----niilc..................................................................
G8PBE9_PEDCP/434-626                 .......................KDQVQQQQDELRPMLKNVDH...RYLQ..LVELALDSDQNSe..ySQFEQ.LTMELVLKHLDFDGKPLG..G..S...NK..PDGI......AW.........-.D....NDGnfI.IFDTKAYNKGYS..L.A-GNTDK.V.K.RYIDDVRDRDTSRT-STWWQLVPKS..I..D..V.HNllrFVYVSGNFTGNYMKLLDSLRSWS.NAQGG.LASVEKLL.LTSELYLR.NMYSHQELIDSWtDNNV-k......................................................................
A0A2C1JY71_9BACI/346-503             ...............aldsfeas--------------------...----..YFDMALKGREQC....REFEI.ATVELFDKAFGFDTSHVG..D..K..gKH..PDIL......AV.........S.E....QFS..G.IIDSKAYAS-YT..I.SNDHKNR.M.ThNYIPPYRKQYPNLD-----------..-..-..-.-F...FMYIAGGFGRNFDKQVLSVAQES.NLNGC.GITANNII.KLARNYKI.NNWTHDNLQQLF.TLNK-e......................................................................
A0A174M7L2_9CLOT/384-570             .......................KSDMAVIKDSVRGRLAHVSH...EYLL..LIDLGFDGTSD-....RDYEI.QTAELLTRELDFLGGRLG..D..T...RK..PDVC......IY.........Y.G....KDG..M.IIDNKAYGKGYS..L.PIKQADE.M.Y.RYLEENKERNEKINPNRWWKVFDEG..V..T..D.YR...FAFVSGSFTGGFKDRLENIHMRS.GLCGG.AMDSVTLL.LLAEELKA.GRMEYSEFFRLF.DCNDE.......................................................................
A0A3D9KY00_9BACT/253-432             ....qlritanfelsdylipkva--------------------...---K..LIDLGNQTDKSAaskgTEYEK.LVAEI-FKLLDFEVDVLGqgS..G...RN..PDAI......IKl.......rE.E....NTA..F.LVDAKAYSNGYS..L.G-TDDRA.I.K.EYINHYCP-----------KLQKEG..Y..K..K.IG...FIIVSNSFKSNFDPFINEITWNT.DIKRFiLLTSEALL.YLLAYKTK.DRLSLSTMIES-.-----ligfan.................................................................
R4KJN4_9FIRM/354-509                 ..................fmtey--------------------...----..-FEMAFKGRDEA....TEFEK.ATVELFKSVFEFEAQHVG..P.iG...LT..PDVY......IL.........S.H....ESRyvG.IIDNKAYSK-YT..I.S---NDH.R.N.RMVH------------NYIKTYSAE..C..Y..PlAF...FSYIAGGFGKNITSQIKDIVDET.LIHGS.AMSVSNMI.KMVENHQY.KKYSHDEIRNIF.S----vdrq...................................................................
A3DG90_HUNT2/353-511                 ..................fmtey--------------------...----..-FEMAFKGRDEA....SDFEK.ATVQLFQNVFGFEAKHVG..P.iG...LT..PDVL......IL.........S.D....KDGyqA.IIDNKAYSK-YT..I.SN---DH.H.N.RMVHNYIG-----NLNR-YSNSSDP..L..A..-.-F...FSYIAGGFGKNINSQIIDIVNAT.GVSGS.AMSVSNMI.KLVESYES.KHYTHKNIRDIF.SVNR-q......................................................................
A0A1H6V5X4_9FIRM/353-512             ..................fmany--------------------...----..-FELAFNGREDC....RKFEI.ATAEIFKNVFGFTSHHIA..G..G...AKevPDVL......LI.........A.E....NAGyqA.IIDTKAYNR-YD..L.GATQRDR.MiY.HYLQDIQTYSSSTLP----------..-..-..V.GF...FSYIAGGFSNNIASPLCKIVNAT.GVNGS.AMPVAAFI.KMAERQGN.SPYTKDEICQIF.SVNR-k......................................................................
A0A1G4FI67_9FIRM/347-528             eiekqieekvthyngsipsriva--------------------...---D..LIRYGYDGRNSS....TLFEM.-TVNTMFKFLGYESEHLG..E..Gk.gRV..ADVIskyrshLY.........A.K....SYG..I.IIDAKAYER-YN..F.PAGDVRK.M.K.EYISLHGE-----------QLLEDK..I..P..R.HV...FAFVSMDFT-NEESALNEIARDT.AVNGT.SITVDTLL.KLGEMVTN.QEVNIADIYDWY.NTNK-r......................................................................
A0A137SQ27_9FIRM/380-565             ....................ktn---ILELKDKVRDKLKYVDH...RYLA..LIDLAYDGTAN-....RDFEI.QTIDLLINELKFKGVRLG..E..S...RK..PDGI......IS.........Y.N....ING..V.IIDNKAYSTGYN..L.PINQADE.M.I.RYIEENQTRDEKINSNKWWESFDEK..V..K..D.FN...YLFVSSFFKGNFKNNLKHIANRT.GVNGG.AINVENLL.YFAEELKA.GRISYLDSFKMY.-NN--de.....................................................................
A0A0D4CKH1_LACMC/394-582             ................eadvtse-----KIKNHFR-RVTELPE...RYLE..LLDIAFDHKRN-....RDFEM.VTAGLFKDVYGLESVHLG..G..A...NK..PDGV......VY.........N.D....NFG..I.ILDTKAYENGYG..K.HISQIDE.M.V.RYIDDNRLRDTTRNPNKWWENFDAD..IpsD..Q.FY...YLWVSGKFLPNFAEQLKQTNYRS.HANGG.GLEVQQLL.LGADAVKR.RKLDVNTIPNYM.K----nev....................................................................
A0A0F2J3F6_9BACT/386-573             .....................ks--NILDVIEKCREKINNIPH...EYLA..LIPMSFDENES-....TMFEI.KTIELLTEHCKFDGLHCG..G..A...SK..PDGL......IY.........S.E....DYG..V.IIDTKSYKDGFN..I.QTPERDK.M.K.RYIEENQNRNPQHNKTRWWDEFPHN..I..S..N.FL...FLFVSGKFGGNFKEQLRILSEQTnNTLGG.ALSSYVLL.NIAEQIAI.NKIDHCDFKTRI.-----sclde..................................................................
A0A1H9CRR6_9FLAO/267-430             ................ylipkvs--------------------...---K..LIELGSETDKSAsskgSAYEK.LVAEI-FKQLDFEVETLG..QgsG...RN..PDAI......LRh.......rE.E....NTA..F.LVDAKAYSNGYS..L.GIDD-RA.I.K.EYINHYCP-----------KLQKEG..Y..K..K.IG...FIIVSNSFKSNFDSFINEITWNT.DIKRFiLLSSEALL.YLLA----.------------.-----fktkdrippatiietlv......................................................
A0A370GG05_9BACI/339-509             ...nhqvedalanfrpdtfshfe--------------------...--AS..YLNMALSGTELA....ADFEI.ATGG-IFEELGFDSEHVG..N..Q..pLH..PDVF......VRs.......pL.N....FS-..G.IIDTKAYRQ-YT..I.S------.-.-.-----NDHRNRMIN--NYIPTYQNG..N..N..L.EF...FMYVADGFGTNIDTQVQDIATRT.NVNGS.VITAQNMI.RLLQRHSS.NPLDHNRLRMLF.TQN--si.....................................................................
A0A3E2NAJ0_9CLOT/385-571             .......................KSEVSILKDYLRSHLTHIDH...KYLI..LVDLGYDGTSD-....RDYEI.QTAQLLTAELSFLGGRLG..D..T...RK..PDVC......IY.........Y.E....DNG..L.IIDNKAYGKGYS..L.PIKQADE.M.Y.RYIEENKERSQLLNPNCWWDIFGKD..V..K..T.FH...FAFVSGEFTGGFRDRLNHISMRS.GLKGA.AVNSANLL.IMAEKLKA.GTMEYGEFFRFF.DTNDE.......................................................................
A0A0L8F1Z2_9CLOT/353-511             ..................fmtey--------------------...----..-FEMAFKGRDEA....VDFEK.ATVKLFENVFGFQAKHVG..P.iG...LT..PDVL......IL.........S.D....EYGyqA.IIDNKAYSK-YT..I.S---NDH.H.N.RMVHNYIE---NLN---LYSN--YN..V..P..L.GF...FTYIAGGFGKNINSQIIDIVNAT.GMSGS.VISVSNMI.KLVEVYQS.RNYTQKNIKDIF.SINR-q......................................................................
A0A261EPN2_9BIFI/357-517             .................flanyy--------------------...----..--EMAFKGTDKA....TDFEK.ATTDLMRDVFHYDATHLG..Q..TgskSA..PDIL......LI.........S.D....DEGyqA.IIDNKAYSR-YS..I.T---GDH.H.N.RMVHNYIGKLDTYSSSAYP------..-..-..L.AF...FAYVAGGFAPSIDKQLRAEVNEG.GVHGS.GITVSVFI.DMIKKSEQ.TAYTHARLRDIF.S----ldrq...................................................................
A0A1Q2MCL2_9BACT/389-442             ....................dyi----ERSKDMLRKYLEKLDH...GYLD..MLDLGASGRKKS....RLFET.RIVDLLKAD---------..-..-...--..----......--.........-.-....---..-.------------..-.-------.-.-.-------------------------..-..-..-.--...-----------------------.-----.--------.--------.------------.-----sthkc..................................................................
A0A419T8E6_9FIRM/385-571             .......................KSEVSVFKDYLRTHLAHVDH...RYLI..LVDLGFDGSSD-....RDYEM.KTAELLTTELGFKGARLG..D..T...RK..PDVC......VY.........H.G....NNG..L.IIDNKAYGKGYS..L.PIKQADE.I.N.RYIEENKERNELLNPNRWWNIFDHT..V..T..H.FR...FAFISGSFTGGFKDRLNLISMRS.GICGA.AINSVNLL.LMAEELKA.GRLGYEEWFEAF.DCNDE.......................................................................
A0A1Q2MCG4_9BACT/7-145               ...................ivia--------------------...----..------------....-----.--------------KHLS..G..G...NR..PEIV......CYhp.....edK.P....DHG..L.ILDSKAYKSGFT..I.PSGERDK.M.V.RYIEEYITKNQLQNPNEWWKNLKGAeyP..G..I.VG...FGFISNSFLGHYRKQLDYIMRRT.KIKGS.SITTEHLL.KTVEDVLS.EKG---------.-----nvidffkyfl.............................................................
A0A1G7YEM4_9MICO/328-494             ...............rvmpdrsr----------------TLDQ...FLLG..YAEMARSSRERA....RDFEL.ATTDVFKRVFELDARHVG..G..A..gRE..PDVV......VD.........N.N....NSW.rI.IVDTKAHGNGYT..L.PASDERA.M.K.EYVAAYAQKSPKLK-----------..-..-..-.-A...WVFISSSFGASINPRLRKIVDET.GVPGS.AVGITAWI.ALIQHAQD.GRVDAEMLLALL.-----svgre..................................................................
A0A371AUI5_9FIRM/357-517             ..................fmtey--------------------...----..-FEMAFKGTEEA....IQFEE.ATTELFSEVFGFKAKHLG..Q..TgskSA..PDVL......LL.........S.D....DAGyqA.IIDNKAYSR-YS..I.S---GDH.H.N.RMVHNYL--NNISN----YSEYQQP..I..G..-.-F...FTYISGGFGNQIDRQIQSIAEES.GIHGS.GMSVSNMI.KLVEKQNE.KPLTHQMIREIF.S----vdrq...................................................................
E7MMY8_9FIRM/18-118                  ..................fmtsy--------------------...----..-FEIAFKGKDEA....TDFEK.ATTEIFISVFKYKAQHLG..Q..TgskSA..PDIL......LI.........S.D....EDGyqS.IIDNKAYSE-YS..I.NGDHHNR.MvH.NYIRNIKN-----------------..-..-..-.--...-----------------------.-----.--------.--------.------------.-----yssceypigyf............................................................
A0A1T4XBI7_9CLOT/353-511             ..................fmtey--------------------...----..-FEMAFKGRDEA....SDFEK.ATVQLFQNVFGFEAKHVG..P.iG...LT..PDVL......IL.........S.D....KDGyqA.IIDNKAYSK-YT..I.SN---DH.H.N.RMVHNYIG-----NLNR-YSNSSDP..L..A..-.-F...FSYIAGGFGKNINSQIIDIVNAT.GVSGS.AMSVSNMI.KLVESYES.KHYTHKNIRDIF.SVNR-q......................................................................
A0A1Y4GEU6_9BACT/395-585             .......................KSDFEETKEQIRGKLLHLPH...EYLS..LIDLAYDSKQN-....RLFEM.KTLGLLTEECGYQGLHLG..G..S...RK..PDGI......IYts.....seK.Y....NYG..V.IIDTKAYSRGYN..L.PISQADE.M.E.RYIGENQTRDAKINPNKWWKHFPEE..V..N..E.FY...FMFVSGHFIGNFKAQIMRISRNK.AINGT.AIAVANLL.LCVEAYKA.GQLTHEVIKTKV.FNNG-e......................................................................
A0A5J6PML6_9BACI/351-509             ..............dtfsqfeas--------------------...----..YLNMAISGTELA....TEFEI.ATRG-IFEQLGFHAEHVG..N.hA...LH..PDIF......VE........sP.Q....NYS..G.IIDTKAYR-TYT..I.N------.-.-.-----NDHRNRMVN--NYIPTYQNQ..Y..G..N.VE..fFMYVADGFGSNIASQVQNIADRT.NVNGS.VITARNVI.RLLQRYQA.TPIDHNSLRILF.ANN--sv.....................................................................
A0A1Y1RMG1_9MICC/398-585             ...................iser----ATQKERLM-QSTDLPM...RFYE..LIDIAYDGRRN-....RDFEM.LTMDLLREGYGFETQLLG..G..G...RK..PDVI......AY.........N.D....DFG..I.IVDTKAYGKGYH..R.SQPEEDK.M.V.RYVEDNRERDASVNNTQWWLGFPET..L..SyqS.VY...FLWVSSFFTGQFGSQLTNTAIRS.RTNGA.ALGVENLL.VGADKFLK.GKLNHNQIQLKI.-----rqdse..................................................................
G5IJL9_9CLOT/353-511                 ..................fmtky--------------------...----..-FEMAFKGRDEA....TEFEK.ATAELFQDVFGFETKHVG..P.iG...LT..PDVL......LI.........S.D....CAGyqA.IIDNKAYHK-YT..I.N---NDH.Y.N.RMVHNYIG-----NMNKY-SSSNN-..-..A..L.AF...FSYIAGGFGSHIDSQIKSIADAT.GVNGS.AMSVTNVI.KMVEQHNK.QPYSHEKIKDIF.SVNR-q......................................................................
A0A1C7G2F5_9FIRM/353-511             ..................fmtky--------------------...----..-FEMAFKGRDEA....TEFEK.ATVELFQDVFGFEAKHVG..P.iG...LT..PDVL......LL.........S.D....ESGfqA.ILDNKAYHK-YT..I.N---NDH.Y.N.RMVHNYIGN--IGN----YSKSDEP..L..-..-.AF...FSYIAGGFGSNIDKQLKNIVDAT.DVNGS.AISVSNVI.KMVEQHRE.KPYTHQRIKDIF.SVNR-q......................................................................
T0SG46_9PROT/352-517                 ................rssyeer--------------------...----..LIEVSTGGIKTA....NEFEK.IVTSIFGGILDFKASHIG..Q..K...HR..SAGT.....gAYtdi..ivdiS.G....EEI..V.LIDTKA-SPSYS..L.GSNDFAK.IsS.NYIKNYKELRPSSS-----------..L..N..-.-S...FGVVAGGFKGNVESRLREIKELT.GVPAF.AITASALV.RLSSYIEN.KTFGKADILRLF.-----sscsv..................................................................
E0NM75_9FIRM/380-566                 ......................k-TNVLELKDKVRDKLKYVDH...RYLA..LIDLAYDGTAN-....RDFEI.QTIDLLINELKFKGVRLG..E..S...RK..PDGI......IS.........Y.N....ING..V.IIDNKAYSTGYN..L.PINQADE.M.I.RYIEENQTRDEKINSNKWWESFDDK..V..K..D.FN...YLFVSSFFKGNFKNNLKHIANRT.GVSGG.AINVENLL.YFAEELKA.GRLSYVDSFKMY.DND--ei.....................................................................
A0A1Y4GKR9_9BACT/395-585             ......................k-SDFVETKERIRDKLLHLPH...EYLS..LIDLAYDSKQN-....RLFEM.KTLGLLTEECGYHGLHLG..G..S...RK..PDGI......IY.........T.DteryNYG..V.IIDTKAYSRGYN..L.PISQADE.M.E.RYIGENQTRDVKINPNKWWEYFPAD..V..E..E.FY...FMFVSGHFIGNFRSQIERISRNK.AINGT.AIAVANLL.LCVEAYKA.GELTHEAIKTKV.FNNG-e......................................................................
A0A367XT96_9MICO/336-508             .ekvarrilgtdrtlssyllhyq--------------------...----..--SLVTSSDRNA...pREFEQ.ATAEIIRRVFKLEATCVG..Q..T..gRE..PDIV......VR.........KpG....EWR..G.IIDTKAYGGEYS..L.PSGHDRA.M.R.EYVEKY-------------------..-..-..-.--...-----------------------.-----.--------.--------.------------.-----sgdggddlrfwvflagslsknagararelaqrigcqgvviglsawmkmielgqagklsgdklgwlfsldge
A0A1D3TWI2_9FIRM/353-511             ..................fmtky--------------------...----..-FEMAFKGREEA....VDFEK.ATVELFHDVFGFESKHVG..P.iG...LT..PDVL......LI.........S.D....LDGyqA.IIDNKAYSK-YT..I.SNDHYNR.MvH.NYIENLANYSESNN-----------..-..N..L.AF...FSYIAGGFGSNIDGQIRNIVNTT.GINGS.AISVSNVI.RMVDIHNS.NPFNHQKIKDVF.SMNR-q......................................................................
A0A1M6KKE2_9FIRM/357-511             ....................sey--------------------...----..-FEMAFRGRDDA....TEFEL.ATVELFKTAFDFKAEHVG..P.iG...LT..PDVL......VF.........S.D....SDKyiG.ILDNKAYSK-YT..I.N---NDH.R.N.RMVHNYIKTYGSGQ--K--------..Y..P..L.KF...FGYIAGGFGNNINSQLKSIVEET.EVHGA.VMSVSNMI.KLVENYSS.NGYTHAKIKDIF.T----vdrq...................................................................
A0A1C0BUS6_9FIRM/388-576             .....................kd--KASEQRKAEFMNKTDLPA...KYIE..LLEIAFDGNRN-....RDFEI.ITAEIFKKVYGLKSVLLG..G..G...RK..PDCL......VF.........N.A....NFG..M.IIDTKAYSTGYS..K.SISQEDE.M.V.RYIEDNQYRDTTRNPIEWWNNFPSS..I..KkeK.YY...FMWVSSKFIGRFQEQIESTYNRT.NTKGA.ALNVEQLL.LGANAVLR.GELDANRISDYI.DNK--ei.....................................................................
A0A172Q519_9STRE/387-574             .......................KDEQSEKRKAYFLKETNLPL...KYIE..LLDIAYDGKRN-....RDFEI.VTMELFRNVYRLQSKLLG..G..V...RK..PDGL......LY.........K.H....RFG..I.IVDTKAYGEGYS..K.SISQADE.M.I.RYIEDNKRRDENRNSTKWWEHFPDC..IpkQ..S.FY...FMWVSSKFVGKFQEQLDYTANET.KTNGA.ALNVEQLL.WGADLVAK.GKLDISQLPSYF.-QN--ke.....................................................................
A0A1M7IV76_9FIRM/395-587             .......................KSEVETIKEQMRGELTHLSH...EYLG..LLDLAYDSKQN-....RLFEL.KTMQLLTEECGFEGLHLG..G..S...RK..PDGI......VYtkdeneqvgK.E....NYG..I.IIDTKAYSGGYS..L.PISQADE.M.E.RYIGENQTRDIRINPNEWWKNFGDG..V..T..E.YY...YLFVAGHFKGKYQEQIDRINCNK.NIKGA.AVSIQQLL.RIVNDYKA.GKLTHEDMK---.-----lkifh..................................................................
A0A1K1PVB9_RUMFL/386-572             .......................KSDLSLLKDDIRKKLNHINH...KYLV..LIDLGFDGTAD-....RDYEL.QTADLLTSELAFKGARLG..D..S...RK..PDVC......VY.........H.D....KNG..L.IIDNKAYGSGYS..L.PIKQADE.M.L.RYIEENQKRDKALNPNEWWTIFDDA..V..S..K.FN...FAFVSGEFTGGFKDRLENISRRS.YTNGA.AINSVNLL.LLAEEIKS.GRISYGDAFTKF.ECNDE.......................................................................
A0A1N6XYH3_9SPIO/344-499             ..................fmney--------------------...----..-FEMAFKGRDEA....TAFEK.ATSEIFRNVFLFQSEHIG..Q..K..gLT..PDVV......VI.........S.D....EFGfsG.IIDNKAYSK-YS..I.N---NDH.K.N.RMIHNYIP---------KYKNFK-K..C..D..L.AF...FMYIAGGFSNSFEISIKNISRES.KVNGS.GISVVNLI.KMIEKQIE.KPYCHLSLRSIF.-----slnr...................................................................
A0A1I6BRX5_9BACI/393-582             ...................kgam----EIKKSELRHKLRHVPH...EYIE..LIEIAQDSKQN-....RLLEF.KVVEFFKKIYGYRGKHLG..G..S...RK..PDGA......LF.........T.DglvlNHG..I.ILDTKAYKDGYR..L.PISQADE.M.Q.RYVDENNKRSQVINPNEWWEIYPTS..I..T..D.FK...FLFVSGFFQGDYRKQLERVSHLT.KCQGA.VMSVEQLL.LGGEKIKE.GSLTLEEVGKKF.KN---de.....................................................................
V9H5A9_9CLOT/392-582                 .......................KSNISLLKDELRGQISHISH...EYLS..LIDLAFDSKQN-....RLFEM.KVLELLVNEYGFKGRHLG..G..S...RK..PDGI......VYst.....tlE.D....NFG..I.IVDTKAYSEGYS..L.PISQADE.M.E.RYVRENSNRDEEVNPNKWWENFSEE..V..K..K.YY...FVFISGSFKGKFEEQLRRLSMTT.GVNGS.AVNVVNLL.LGAEKIRS.GEMTIEELERAM.FNNSE.......................................................................
R9JR57_9FIRM/383-569                 .......................KSDFSIIKDNIRRKLQYVNH...KYLL..LIDLGFDSDSN-....RDYEI.QTAELLTTELAFKGARLG..D..T...RK..PDVC......VY.........Y.G....ENG..L.IIDNKAYSKGYS..L.PMSQADE.M.V.RYIEENKARQSSINPNQWWKIFEDT..V..C..N.FN...YAFVSGEFTGGFKDRLNNICERT.RVSGG.AINTINLL.LLAEELKS.GRMSYPKCFSYF.DTNDE.......................................................................
A0A0R1ZT34_9LACO/433-626             .......................KDNVQRQQDELRPLLKHVDH...RYLQ..LVELALDSSQNSe..ySMLES.MTMELLLTHLDFDGASLG..G..A...SK..PDGI......AW.........-.D....KDGnfL.IVDTKAYDNGYS..L.A-GNTDK.V.A.RYIDDVRAKDPNRA-STWWTQVPES..L..N..V.DDnlsFMYVSGSFTGNYQRLLKDLRART.NARGG.LTTVEKLL.LTSEAYLAkSGYGHTQLLNDWtDD---nid....................................................................
I3IKA7_9BACT/89-269                  ...................yvkt-----EISNTITSKLIEEHH...KYLP..QIVHNLDELSVSe..eRHYEFeKKVNLVFQMLEFEVDEYGqgT..G...RN..PDGI......AKd.......nQ.N....RYA..I.IIDAKSRSNGYK..L.G-TDDRQ.I.I.EYINKFKGILD-----------RQG..F..H..K.IY...FLIVSSRFETTSCNSINNIKIET.NTITS.LISSGLLLkILAKKI--.------------.-----elprlfdlkefqkllie......................................................
U2NP01_9CLOT/353-511                 ..................fmtey--------------------...----..-FEMAFKGRDEA....IDFEK.ATVELFQNVFGFESKHVG..P.iG...LT..PDVL......IL.........S.D....EDGyqA.IIDNKAYSK-YT..I.S---NDH.H.N.RMVHNYIKNLERYS--------NSD..V..P..L.AF...FSYVAGGFGKNINTQINDIVNVT.GVSGS.AMSVSNMI.KLVELYES.KNYTHKSIREIF.SVNR-q......................................................................
A0A1V4I7R7_9FIRM/392-581             .......................KSSIEELKSELRTQLNVISH...DYLQ..LVDISQDSQQN-....RLFEM.KVMDLFINEFGYNGSHLG..G..S...RK..PDGI......LYte.....glS.K....DYG..I.IVDTKAYKDGYN..L.PIAQADE.M.E.RYIRENIDRNEVVNPNRWWEVFPSK..I..N..D.YK...FLFVSAYFKGNFKEQLERISINT.GILGG.AISVEHLL.LGAEYFKR.GILSLEDVRDKF.-CNT-e......................................................................
A0A1M4XXY2_9BACT/274-435             .........ipkvaklvelgsqi--------------------...----..----GVTSSAKG....DEFER.LVAEI-FKQLDFDVQLLG..QgtG...RN..PDAI......IRf.......rE.E....NTA..F.IIDAKAYTNGYT..L.G-TDDRA.I.K.EYINHH---CPKLN--------KEG..Y..K..K.IG...FIIVSNSFKSNFDSFINSITWDT.EIKRFiLLTSEALL.YLLAFKTK.------------.-----drlplttiieklv..........................................................
A0A1G4G8X3_9BACT/269-435             ......iiprvsklvelgkatdk--------------------...----..------SSTQKG....YEYEK.LVAEV-FGQLDFEVESLG..QgtG...RN..PDAI......LKf.......rE.E....NTA..F.IVDAKAYNGGFS..L.G--TSDRaI.R.EYINY-----------HCPKLLRNG..Y..K..K.IG...FIIVSNDFRDNFDDFVNSITWDT.DIKRFiLLTSEALL.YLLAFKTK.NRLSLGTVIES-.-----lisfgn.................................................................
A0A1I0RBP4_9FIRM/354-513             ..................lsgyy--------------------...----..--EMAFKGRDEA....VDFEI.ATTSIFKDILGYNAIHLG..Q..TgckSA..PDVL......LI.........S.D....DDGyqA.IIDNKAYSK-YS..I.S---GDH.H.N.RMVHNYIENISNY--------SDSE..Y..K..I.GF...FSYIAGGFSNNIDSQINAIHAET.GVCGS.AITVANVI.RMVENSQD.NSYSHAKIRDIL.GVN--rq.....................................................................
A0A1P8UD22_9MICO/360-517             ................fmteyav--------------------...----..---LAFGSRDRA....TEFEK.ATESIFRDVFGFKTKHIG..Q..Q..gIR..PDVV......ISs.......kS.D....AYA..G.IIDAKAYGESYS..A.SHDHRNR.M.I.AYIKNYPSYAIDDNP----------..-..-..L.AF...FAYVVSEFKTTLTGQLQAIQGEA.GVAGS.AITARDII.RMVERSKS.RPYSHSELRELF.S----sgr....................................................................
R6AWC6_9BACT/400-587                 ..................ttdtv-----AVKNRARLRLHNIDH...KYLT..LIDYAFSGKDKC....IDFEV.YTIDLLVNELAFNGVHLG..G..T...RK..PDGI......FY.........H.N....NNG..V.IIDNKAYSKGFT..I.SRGMADE.M.T.RYVQENNDRNPERNPNQWWLNFSDN..V..N..H.FN...FVFISSLFKGNIELMLNNIKQST.GVEGC.ALTVENLL.YFADAIKG.GDMHKDAFIDQF.G----agke...................................................................
C6JKY8_FUSVA/380-565                 ....................ktn---ILELKDNTREKLVYLDH...RYLS..LFDLAYDDKAS-....RDFEI.QTIDLLINELQFKGLRLG..E..R...RK..PDGI......IS.........Y.G....VNG..V.IIDNKAYSKGYN..L.PIRQADE.M.I.RYIQENQSRDEKLNPNKWWENFEEE..T..S..K.FN...YLFISSKFISGFKKNLQYIADRT.GVNGG.AINVENLL.CFAEMLKS.GKLEYNDFFNQY.-NND-e......................................................................
A0A017RUA6_9CLOT/353-511             ..................fmtey--------------------...----..-FEMAFKGRDEA....SDFEK.ATVQLFQNVFGFEAKHVG..P.iG...LT..PDVL......IL.........S.D....KDGyqA.IIDNKAYSK-YT..I.SN---DH.H.N.RMVHNYIG-----NLNR-YSNSSDP..L..A..-.-F...FSYIAGGFGKNINSQIIDIVNAT.GVSGS.AMSVSNMI.KLVESYES.KHYTHKNIRDIF.SVNR-q......................................................................
R6MYT0_9CLOT/396-586                 .......................KSSQSETKEKLREKLRNLPH...EYLS..LVDLAYDSKQN-....RLFEM.KVIELLTEECGFQGLHLG..G..S...RR..PDGV......LYta.....glT.D....NYG..I.ILDTKAYSSGYS..L.PIAQADE.M.E.RYVRENQTRDELVNPNQWWENFENG..L..G..T.FY...FLFVAGHFNGNVQAQLERISRNT.GVLGA.AASISQLL.LLADAIRG.GRMDRERLRHLM.FQNEE.......................................................................
I3DCT9_9PAST/386-573                 ...................rdkv----IEEQKAIFLQKTKLPL...SYIE..LLEIARDGKRS-....RDFEL.ITMELFKNIYKINASILG..G..A...RK..PDGV......LY.........M.P....EFG..V.IVDTKSYADGYS..K.SIAQADE.M.I.RYIEDNKRRDPSRNSTKWWEHFPTS..IpaN..N.FY...FLWVSSVFVNKFHEQLSYTAQET.QTVGA.ALSVEQLL.LGADSVLK.GNLTTEKFIDSF.KN---qe.....................................................................
A0A1I5VQT4_9FIRM/350-510             .................flanyy--------------------...----..--EMAFKGTEEA....IEFEK.ATTEIFRASFGYNAVHLG..Q..TgakSA..PDVL......LL.........S.D....SEGyqA.IIDNKAYSK-YS..I.T---GDH.H.N.RMVHNYVEKIGNYSNSR------YP..I..-..-.GF...FTYIAGGFISTIDKQIAAEVAEA.NVHGS.GITVATFI.KMIEKNSE.QPYSQKTLRELF.S----ldre...................................................................
D9R4Y5_CLOSW/385-571                 .......................KSEVSLCKDILRSHLTHVDH...KYLI..LLDLGFDGTSD-....RDYEI.QTAQLLTAELDFKGARLG..D..T...RK..PDVC......VY.........Y.G....EDG..L.ILDNKAYGKGYS..L.PIKQADE.M.Y.RYIEENKERNERLNPNKWWEIFDKD..V..V..R.YH...FAFVSGTFTGGFKERLDNIRMRS.GICGA.AVNSMNLL.LMAEELKS.GRLGYKECFALF.DCNDE.......................................................................
A0A0V8JLM2_9BACI/393-582             .....................kg--EMEKKKSDLRHKLKHVPH...EYIE..LIEIAQDSKQN-....RLFEF.KVVEFLKEVYDYNGKHLG..G..S...RK..PDGA......LYtn.....glK.T....DYG..I.ILDTKAYKDGYS..L.PISQADE.M.Q.RYVDENNNRNAIINPNEWWKVYPNS..I..L..D.FK...FLFVSGFFKGDYKKQLARVSNLT.KRKGA.VLSVEQLL.LGGEKIKD.GSLTLEDVGDKF.-NND-e......................................................................
#=GC seq_cons                        ....................t.h..............................h-hAacGcpp.....p-FEh.tTs-Lhpp.hsFcupHlG..s..u...pp..PDsl......lh.........p.c....ptG..h.IIDsKAYucsYo..l.s.spsDc.h.p.RYlcp.pppp..hN..p.hp...pt..l..t....hh...FhaluGtFtsshppplppIsppT.slpGu.ulolpsll.hhs-thpp.sphshpplhpha......p......................................................................
//
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