GenomeNet

Database: Pfam
Entry: FN3_7
LinkDB: FN3_7
Original site: FN3_7 
#=GF ID   FN3_7
#=GF AC   PF18447.1
#=GF DE   Fibronectin type III domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF04719
#=GF GA   34.30 34.30;
#=GF TC   34.70 34.70;
#=GF NC   33.10 33.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   19141282
#=GF RT   Structural and biophysical studies of the human IL-7/IL-7Ralpha
#=GF RT   complex.
#=GF RA   McElroy CA, Dohm JA, Walsh ST;
#=GF RL   Structure. 2009;17:54-65.
#=GF RN   [2]
#=GF RM   22308406
#=GF RT   Structural reorganization of the interleukin-7 signaling
#=GF RT   complex.
#=GF RA   McElroy CA, Holland PJ, Zhao P, Lim JM, Wells L, Eisenstein E,
#=GF RA   Walsh ST;
#=GF RL   Proc Natl Acad Sci U S A. 2012;109:2503-2508.
#=GF RN   [3]
#=GF RM   24632570
#=GF RT   Structural basis of the proinflammatory signaling complex
#=GF RT   mediated by TSLP.
#=GF RA   Verstraete K, van Schie L, Vyncke L, Bloch Y, Tavernier J,
#=GF RA   Pauwels E, Peelman F, Savvides SN;
#=GF RL   Nat Struct Mol Biol. 2014;21:375-382.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is found in Interleukin-7 receptor subunit alpha
#=GF CC   (IL-7Ralpha), which together IL-7 form a complex crucial to
#=GF CC   several signalling cascades leading to the development and
#=GF CC   homeostasis of T and B cells. IL-7Ralpha carries a 219 residue
#=GF CC   ectodomain on the N-terminal region which is crucial for T and
#=GF CC   B-cell development. Mutations in the IL-7Ralpha ectodomain
#=GF CC   inhibits T and B cell development, resulting in patients with a
#=GF CC   form of severe combined immunodeficiency (SCID). The ectodomain
#=GF CC   folds into two fibronectin type III (FNIII) domains connected by
#=GF CC   a 310-helical linker. This entry comprises the first of the two
#=GF CC   FNIII domains, D1 while D2 domain is Pfam:PF00041. In the D1
#=GF CC   domain of IL-7Ralpha, a disulfide bond (C22R-C37R) conserved
#=GF CC   among cytokine receptor class I (CRH I) family members bridges
#=GF CC   two beta strands [1].
#=GF SQ   109
#=GS A0A2I3HB32_NOMLE/32-127     AC A0A2I3HB32.1
#=GS A0A099ZEH9_TINGU/5-99       AC A0A099ZEH9.1
#=GS A0A2K5MI09_CERAT/32-127     AC A0A2K5MI09.1
#=GS F7G3H6_MACMU/32-127         AC F7G3H6.2
#=GS A1EA95_CHICK/38-132         AC A1EA95.1
#=GS L5K796_PTEAL/32-127         AC L5K796.1
#=GS A0A2I2Y3X1_GORGO/32-127     AC A0A2I2Y3X1.1
#=GS G3TAD6_LOXAF/32-127         AC G3TAD6.1
#=GS A0A2K5MHS9_CERAT/32-127     AC A0A2K5MHS9.1
#=GS A0A1U7RZD3_ALLSI/38-132     AC A0A1U7RZD3.1
#=GS K7GLC0_PIG/32-127           AC K7GLC0.2
#=GS A0A0A0A151_CHAVO/38-132     AC A0A0A0A151.1
#=GS A0A091UAT6_PHALP/38-132     AC A0A091UAT6.1
#=GS A0A096N4Q6_PAPAN/32-127     AC A0A096N4Q6.1
#=GS G1N9Q7_MELGA/41-135         AC G1N9Q7.2
#=GS L5M076_MYODS/31-126         AC L5M076.1
#=GS U3JHB6_FICAL/38-132         AC U3JHB6.1
#=GS U3II59_ANAPL/38-132         AC U3II59.1
#=GS A0A2I3BRC2_MOUSE/32-127     AC A0A2I3BRC2.1
#=GS G7P7C5_MACFA/32-127         AC G7P7C5.1
#=GS A0A091KH46_EGRGA/38-132     AC A0A091KH46.1
#=GS S9XNY7_CAMFR/32-127         AC S9XNY7.1
#=GS F6ZUE8_CALJA/32-127         AC F6ZUE8.1
#=GS H0YUU0_TAEGU/38-132         AC H0YUU0.1
#=GS A0A1S3A973_ERIEU/32-127     AC A0A1S3A973.1
#=GS IL7RA_HUMAN/32-127          AC P16871.2
#=GS IL7RA_HUMAN/32-127          DR PDB; 3UP1 A; 12-107;
#=GS IL7RA_HUMAN/32-127          DR PDB; 5J11 B; 37-127;
#=GS IL7RA_HUMAN/32-127          DR PDB; 3DI2 D; 14-107;
#=GS IL7RA_HUMAN/32-127          DR PDB; 3UP1 B; 16-107;
#=GS IL7RA_HUMAN/32-127          DR PDB; 3DI2 B; 17-107;
#=GS IL7RA_HUMAN/32-127          DR PDB; 3DI3 B; 17-107;
#=GS K7FR21_PELSI/1-91           AC K7FR21.1
#=GS A0A093GHP9_DRYPU/37-131     AC A0A093GHP9.1
#=GS A0A091N2S4_APAVI/38-132     AC A0A091N2S4.1
#=GS D4A3X8_RAT/32-127           AC D4A3X8.1
#=GS F7FJP7_MONDO/32-128         AC F7FJP7.1
#=GS A0A094LD52_9AVES/38-132     AC A0A094LD52.1
#=GS G3UPK6_MELGA/1-44           AC G3UPK6.1
#=GS A0A093I967_FULGA/37-131     AC A0A093I967.1
#=GS D6RDM4_HUMAN/32-127         AC D6RDM4.1
#=GS G3VXC5_SARHA/31-127         AC G3VXC5.1
#=GS A0A091TV27_9AVES/38-132     AC A0A091TV27.1
#=GS E2R536_CANLF/32-127         AC E2R536.2
#=GS D2I6N7_AILME/5-100          AC D2I6N7.1
#=GS A0A091CXT9_FUKDA/1906-2003  AC A0A091CXT9.1
#=GS F7I5S8_CALJA/32-127         AC F7I5S8.1
#=GS W5PNL9_SHEEP/32-127         AC W5PNL9.1
#=GS G5C9G9_HETGA/32-129         AC G5C9G9.1
#=GS E1BPM3_BOVIN/32-127         AC E1BPM3.1
#=GS A0A286XQQ4_CAVPO/32-129     AC A0A286XQQ4.1
#=GS A0A093SAW7_PHACA/38-132     AC A0A093SAW7.1
#=GS A0A091HZF9_CALAN/38-132     AC A0A091HZF9.1
#=GS D6RGV2_HUMAN/32-127         AC D6RGV2.1
#=GS D6RG28_HUMAN/32-59          AC D6RG28.1
#=GS A0A093CK76_9AVES/38-132     AC A0A093CK76.1
#=GS H2PFB9_PONAB/32-127         AC H2PFB9.1
#=GS A0A1U7QZS9_MESAU/32-93      AC A0A1U7QZS9.1
#=GS A0A091VN94_NIPNI/38-132     AC A0A091VN94.1
#=GS G3RFX0_GORGO/32-127         AC G3RFX0.2
#=GS A0A093F7X7_TYTAL/35-129     AC A0A093F7X7.1
#=GS G1S1H3_NOMLE/32-127         AC G1S1H3.1
#=GS A0A087VA68_BALRE/38-132     AC A0A087VA68.1
#=GS S7PLB5_MYOBR/31-126         AC S7PLB5.1
#=GS A0A091EI26_CORBR/38-132     AC A0A091EI26.1
#=GS M3WAZ4_FELCA/32-127         AC M3WAZ4.1
#=GS A0A0Q3TEB0_AMAAE/35-129     AC A0A0Q3TEB0.1
#=GS A0A091QIR5_MERNU/38-132     AC A0A091QIR5.1
#=GS G1T184_RABIT/32-127         AC G1T184.2
#=GS IL7RA_CALJA/32-127          AC A5HJM1.1
#=GS A0A1L8HRT3_XENLA/1-98       AC A0A1L8HRT3.1
#=GS A0A091GC95_9AVES/38-132     AC A0A091GC95.1
#=GS IL7RA_MOUSE/32-127          AC P16872.2
#=GS IL7RA_MOUSE/32-127          DR PDB; 4NN5 B; 36-127;
#=GS IL7RA_MOUSE/32-127          DR PDB; 5J12 B; 38-127;
#=GS IL7RA_MOUSE/32-127          DR PDB; 4NN6 B; 37-127;
#=GS IL7RA_MOUSE/32-127          DR PDB; 4NN7 B; 38-127;
#=GS A0A091JVX0_COLST/38-132     AC A0A091JVX0.1
#=GS IL7RA_HORSE/32-127          AC A0MSX9.1
#=GS A0A1V4KDC2_PATFA/35-129     AC A0A1V4KDC2.1
#=GS A0A091M0M7_CARIC/38-132     AC A0A091M0M7.1
#=GS A0A151MWT0_ALLMI/38-132     AC A0A151MWT0.1
#=GS A0A091P3W8_LEPDC/38-132     AC A0A091P3W8.1
#=GS F7DGM3_HORSE/32-127         AC F7DGM3.1
#=GS A0A087RDI7_APTFO/38-132     AC A0A087RDI7.1
#=GS A0A093H3E6_GAVST/38-132     AC A0A093H3E6.1
#=GS A0A2I3MFR4_PAPAN/32-127     AC A0A2I3MFR4.1
#=GS A0A2I0LR56_COLLI/35-129     AC A0A2I0LR56.1
#=GS A0A091S731_NESNO/38-132     AC A0A091S731.1
#=GS A0A226NGD7_CALSU/1511-1605  AC A0A226NGD7.1
#=GS A0A151MWX7_ALLMI/38-132     AC A0A151MWX7.1
#=GS A0A2K5K5D4_COLAP/32-127     AC A0A2K5K5D4.1
#=GS A0A093J883_EURHL/38-132     AC A0A093J883.1
#=GS G3VXC3_SARHA/31-127         AC G3VXC3.1
#=GS A0A1S3FCR3_DIPOR/32-127     AC A0A1S3FCR3.1
#=GS G1PEK7_MYOLU/31-126         AC G1PEK7.1
#=GS A0A2K5K5C9_COLAP/32-127     AC A0A2K5K5C9.1
#=GS A0A0D9RWV1_CHLSB/32-127     AC A0A0D9RWV1.1
#=GS A0A093SZ80_9PASS/38-132     AC A0A093SZ80.1
#=GS B8YG18_HUMAN/32-127         AC B8YG18.1
#=GS A0A091XYH3_OPIHO/38-132     AC A0A091XYH3.1
#=GS A0A218UVK6_9PASE/101-195    AC A0A218UVK6.1
#=GS A0A1D5QDM4_MACMU/32-127     AC A0A1D5QDM4.1
#=GS H2QQR6_PANTR/32-127         AC H2QQR6.2
#=GS A0A093RJ38_PYGAD/38-132     AC A0A093RJ38.1
#=GS A0A226PGG9_COLVI/35-129     AC A0A226PGG9.1
#=GS L9JTG1_TUPCH/1584-1679      AC L9JTG1.1
#=GS A0A091LCP5_CATAU/38-132     AC A0A091LCP5.1
#=GS F7A0L8_ORNAN/32-128         AC F7A0L8.1
#=GS G3VXC4_SARHA/31-127         AC G3VXC4.1
#=GS A0A1A6GX46_NEOLE/41-136     AC A0A1A6GX46.1
#=GS A0A1U7TCP5_TARSY/32-127     AC A0A1U7TCP5.1
#=GS A0A091MWY5_9PASS/38-132     AC A0A091MWY5.1
#=GS M3YUE3_MUSPF/32-127         AC M3YUE3.1
#=GS G3HKG1_CRIGR/20-80          AC G3HKG1.1
#=GS A0A2I3SFV9_PANTR/32-127     AC A0A2I3SFV9.1
#=GS A0A091RAC7_9GRUI/37-131     AC A0A091RAC7.1
#=GS A0A091KTQ5_9GRUI/38-132     AC A0A091KTQ5.1
#=GS A0A093HNN9_STRCA/37-131     AC A0A093HNN9.1
A0A2I3HB32_NOMLE/32-127                ......DAELD.DYSFSCYSQLEVNGSQHSLTCA.FEDPDV.NTTNLEFEICGAL-..VEVKCLNFRK.LQEIYFIETKKFLLIGKSNICVKAGEKSLTCKKIDLTTIV.................
A0A099ZEH9_TINGU/5-99                  ......DDEPD.SLDINCFSQLEFKDSYSSLTCN.FTELPP.PDTNYSLAVCTKED..SSYICSNMEK.HEDEYFSQFTD--ILSKRYVCMDSEMKRKICKSLILTEIV.................
A0A2K5MI09_CERAT/32-127                ......DAELD.DYSFSCYSQLEVNGSQHSLTCA.FEDPDV.NTTNLEFEICGAL-..VEVKCLSFRK.LQEIYFIETKKFLLIGKSNICVKVGGKSLTCKKIDLTTIV.................
F7G3H6_MACMU/32-127                    ......DAELD.DYSFSCYSQLEVNGSQHSLTCA.FEDPDV.NTTNLEFEICGAL-..VEVKCLSFRK.LQEIYFIETKKFLLIGKSNICVKVGGKSLTCKKIDLTTIV.................
A1EA95_CHICK/38-132                    ......DDEPD.NFDIDCFSQLEFKDSYSSLTCN.FTELPP.HNTNYTLAVCTKED..SSYLCFNMEK.QEDVYFLQFTD--ILSNKDICVEYEIKRRACRSLIVTDIV.................
L5K796_PTEAL/32-127                    ......DAELD.DYSFSCYSQLEVNGSQHLLNCT.FDDPDV.NSTDLEFEICEAL-..VGVNCLNFSK.HQEMYLIKTNKFLLIGDSKICVKLGGKIVTCRKMKIVNIV.................
A0A2I2Y3X1_GORGO/32-127                ......DAELD.DYSFSCYSQLEVNGSQHSLTCA.FEDPDV.NTTNLEFEICGAL-..VEVKCLNFRK.LQEIYFIETKKFLLIGKSNICVKVGEKSLTCKKIDLTTIV.................
G3TAD6_LOXAF/32-127                    ......DAEPD.DYSFSCYSQLEVNGSQHSLTCA.LDDPDV.NSTNLEFEICGAL-..LEVNCLNLNK.LQDMYFIRTKKFLLIGDSDICVKLGQKSITCKTMNIVKIV.................
A0A2K5MHS9_CERAT/32-127                ......DAELD.DYSFSCYSQLEVNGSQHSLTCA.FEDPDV.NTTNLEFEICGAL-..VEVKCLSFRK.LQEIYFIETKKFLLIGKSNICVKVGGKSLTCKKIDLTTIV.................
A0A1U7RZD3_ALLSI/38-132                ......DDELD.NPEIDCFSQLEIVSSLHALICS.FSEPSL.NNTNFQIVSCVSEE..RIEKCSQMKK.QESTYSLEFSQ--ILLPRRVCVILESKRKYCSSLKVISIV.................
K7GLC0_PIG/32-127                      ......DAEPD.DYSFSCYSQLEVDGPQHLLTCS.FDDPDV.NSTHLEFEICGGL-..LDINCLSFNK.LQEMYFIKTKKFLLIGDSKICVKLGGKNMTCRKMKIVKIV.................
A0A0A0A151_CHAVO/38-132                ......DDEPD.NFDINCFSQLEFKDSYSSLTCN.FTELPP.HNTNYTLALCTKED..SNYVCFNMEK.QEDVYFLQFTD--ILSNKDICMDSETKRRVCRSLVVTDIV.................
A0A091UAT6_PHALP/38-132                ......DDEPD.NFDINCFSQLEFKDSYSSLTCN.FTEMPP.HNTNYTLALCTKED..SNYMCFDMEK.QEDAYFLQFTD--ILSNKDICMDSEIKRRVCRSLVVTDIV.................
A0A096N4Q6_PAPAN/32-127                ......DAELD.DYSFSCYSQLEVNGSQHSLTCA.FEDPDV.NTTNLEFEICGAL-..VEVKCLSFRK.LQEIYFIETKKFLLIGKSNICVKVGGKSLTCKKIDLTTIV.................
G1N9Q7_MELGA/41-135                    ...gst----R.NYKISCSSQWELHDCTSSLSSKmFPWVFP.HTVNTTLANSTKED..SSYPCFNMEK.QDDVYFLQFTD--ILSNKDICVEYEIKRRVCRSLIVTDIV.................
L5M076_MYODS/31-126                    .....eDAEPD.-YSFSCYSQLEVDGSQHLLRCA.FDDPDV.NSTYLEFEICEHL-..LGVKCLNFIK.QQEIYFIKTNKFLLIGDSKICVKLGQRILTCRKMSIVHIV.................
U3JHB6_FICAL/38-132                    ......DDEPD.NFDIDCFSQLEIKDSFSSLTCN.FTELPP.YNTNYTLSLCTKED..NDYACSNMKK.QEDVFFIQFID--ILSNRDVCMYSEMKRRVCRSLVITDIV.................
U3II59_ANAPL/38-132                    ......DDEPG.NFDIDCFSQLEFKDSYSSLTCN.FTEMPP.HNTNYTLAVCTKED..SNYVCFNMEK.RDDVYFLQFTD--ILSNKDICMEYEIKRRVCRSLSVTDIV.................
A0A2I3BRC2_MOUSE/32-127                ......DADAD.DHSFWCHSQLEVDGSQHLLTCA.FNDSDI.NTANLEFQICGAL-..LRVKCLTLNK.LQDIYFIKTSEFLLIGSSNICVKLGQKNLTCKNMAINTIV.................
G7P7C5_MACFA/32-127                    ......DAELD.DYSFSCYSQLEVNGSQHSLTCA.FEDPDV.NTTNLEFEICGAL-..VEVKCLSFRK.LQEIYFIETKKFLLIGKSNICVKVGGKSLTCKKIDLTTIV.................
A0A091KH46_EGRGA/38-132                ......DDEPD.NFEIDCFSQLEFKDSYSSLTCN.FTELPP.HNTNYTLALCTKED..SNYLCFNMEK.QEDAYFLQFTD--ILSNKDICMDSEMKRRVCRSLVVTDIV.................
S9XNY7_CAMFR/32-127                    ......DAELD.DYSFSCYSQLEVNGSQHLLTCA.FDDPDV.NSTNLEFEICGAL-..LDVNCLSFNK.LQEMYFIKTKKFLLIGDSEICVKLERKSMTCRKMNIVKIV.................
F6ZUE8_CALJA/32-127                    ......DAELD.DYSFSCYSQLEVNGSQHSLTCA.FEDPDV.NTTNLEFEICGAL-..VEVRCLNFRK.LQEIYLIETKKFLLIGNSNICVKAGEKSLTCKNVNVATIV.................
H0YUU0_TAEGU/38-132                    ......DDEPD.NFDIDCFSQLEIKDSFSSLTCN.FTELSP.YNTNYTLSLCTKED..NNYACSNMKK.QEDVFFLQFID--ILSNRDVCMYSETKRRVCRSLVVTDIV.................
A0A1S3A973_ERIEU/32-127                ......DAELD.DYSFTCFSQLEVNGSQHSLTCT.FDDPEV.NSTNLEFEICDAL-..LYAKCLDFHK.LKEMYILMTKKFLLIGDSNVCVKLRRKNITCRKMNIVNIV.................
IL7RA_HUMAN/32-127                     ......DAELD.DYSFSCYSQLEVNGSQHSLTCA.FEDPDV.NTTNLEFEICGAL-..VEVKCLNFRK.LQEIYFIETKKFLLIGKSNICVKVGEKSLTCKKIDLTTIV.................
#=GR IL7RA_HUMAN/32-127          SS    ......XXXGG.GG-EEEEEEEEEETTEEEEEEE.ESSTTS.SSTTEEEEEESSB-..SSSSEEE-EE.ETTEEEEEES-B--SSEEEEEEEETTEEEEEEEEEGGGSB.................
K7FR21_PELSI/1-91                      ......-----.DLETECFSQLEIKEFSHSLTCN.FMEVNL.NSTNINLTVCPTL-..FRPKCLGTQK.SKDFFFITTENYEIISCKEICVVLESKRKDCKRVTVTDIV.................
A0A093GHP9_DRYPU/37-131                ......DDESG.NFDIDCFSQLEFKESYSSLTCN.FTELPP.RNTNYTLALCTKED..SNYLCFNMEK.REDVYFLQFTD--ILSNKDICVNSETKRKVCWSLVVTDFV.................
A0A091N2S4_APAVI/38-132                ......DDEQD.NFPIDCFSQLDYKNSYSSLTCN.FTEMPP.HNTNYNLFLCTKEG..RDSVCFKMEK.QEDAYFLQFSD--ILSNKDICLDSKVTRRVCRNLVVTDIV.................
D4A3X8_RAT/32-127                      ......DAEPD.DHSFWCHSQLEVDGNQHSLTCA.FNDPDI.KTTNLEFQICGAL-..LGIDCLTLNK.LREMYFIKTSKFLLIGNSSVCVKLGKMDVICKILDISTIV.................
F7FJP7_MONDO/32-128                    ......DEEQD.DYEFTCYSQLQGHGQEHTLTCY.FNNLTL.HSNDLELKLCGAFM..SEPQCEMMIK.RENDYFMKSRSFSLINTCEINVILGRSKVNYKSFKITKIV.................
A0A094LD52_9AVES/38-132                ......DDEPD.NFDIDCFSQLEFKDSYSSLTCN.FTELPP.HNTNYTLALCTKED..SNYVCFNMEK.QEDAYFLQFTD--ILSNKDICMDSEPKRRVCRSLVVTDIV.................
G3UPK6_MELGA/1-44                      ......-----.----------------------.------.--------------..----CFNMEK.QDDVYFLQFTD--ILSNKDICVEYEIKRRVCRSLIVTDIV.................
A0A093I967_FULGA/37-131                ......DDESD.NFDIDCFSQLEFKDSYSSLTCN.FTELPP.HNINYTLALCTKED..SNYVCFNMEK.QEDAYFLKFTD--ILSNKDICMDSEMKRKVCRSLVVTDIV.................
D6RDM4_HUMAN/32-127                    ......DAELD.DYSFSCYSQLEVNGSQHSLTCA.FEDPDV.NITNLEFEICGAL-..VEVKCLNFRK.LQEIYFIETKKFLLIGKSNICVKVGEKSLTCKKIDLTTI-g................
G3VXC5_SARHA/31-127                    ......DEEQD.DYDFTCYSQLQVYGQQHTLTCS.FNDSSV.NSTYLELKLCRSLM..TNSRCEIMMK.REKDYFIQSRSFSLIKSCKMCVIFRKSKMNCKTLKITKIV.................
A0A091TV27_9AVES/38-132                ......DDEPD.NFDIDCFSQLEFKDSYSSLTCN.FTEPPP.QNTNYTLALCTKED..SNYVCFNMEK.QEDAYFLQFTD--ILSNKDVCMDSETKGRVCRNLVVTDIV.................
E2R536_CANLF/32-127                    ......DAELD.DYSFSCYSQLEVDGTQHLLTCT.FDDPDI.NSTNLEFEICGAL-..LNVKCLTFNK.LQEMYFIKTKKFLLIGDSEIYVKLEGKNITSKKLNIVRIV.................
D2I6N7_AILME/5-100                     ......DAELD.DYSFSCYSQLEVDGTQHLLTCA.FDDPDI.NSTNLEFEICGAL-..LNVKCLTFDK.LQDMYFIKTKKFLLIGDSEIYVKLGGKNITSKKLNIVEIV.................
A0A091CXT9_FUKDA/1906-2003             ......DAESDtDYSFSCYAQLEVDRSQHSLTCA.FDDPDI.NSTNLELEICKSL-..VGVECMKFSKlQEEKYFIKTKKFLLLGESKICVKLGEDNLACKQVEISHLV.................
F7I5S8_CALJA/32-127                    ......DAELD.DYSFSCYSQLEVNGSQHSLTCA.FEDPDV.NTTNLEFEICGAL-..VEVRCLNFRK.LQEIYLIETKKFLLIGNSNICVKAGEKSLTCKNVNVATIV.................
W5PNL9_SHEEP/32-127                    ......DTELD.DYSFSCYSQLEVDGLQHLLTCT.FDDSDI.NSTNLELEICGAL-..LDVYCLNFNK.LQERYFLKTKKFLLIGDSKICVKLEKKNMTCRKVNIVKIV.................
G5C9G9_HETGA/32-129                    ......DAESDtDYSFSCYAQLEVDGSQHSLTCA.FDDPDI.NSTNLELEICKGF-..VGVECMNFSKlQEEKYFIKTKKFLLVGESKICVKLGEETLACKTVEIAHLV.................
E1BPM3_BOVIN/32-127                    ......DAELD.DYSFSCYSQLEVDGLQHLLTCM.FDDSDI.NSTNLEFEICGAL-..LDVDCLNFNK.LQERYFLKTKKFLLIGDSKICVKLEKKNMTCRKVNIVKIV.................
A0A286XQQ4_CAVPO/32-129                ......DAESDtDYAFSCYAQLEVDGAQHSLTCA.FDDPDI.NSTNLEFEICESL-..VGIDCMNLNKlQEEKYFIKTKKFLMIGQSKICVKLREENLACKSVEIVHIV.................
A0A093SAW7_PHACA/38-132                ......DDEPD.NFDIDCFSQLEFKDSYSSLTCN.FTDLPP.HNTNYTLSLCTKED..SNYVCFNMKK.QEDGYFLQFTD--ILSNKDICMNSETKRRVCRSLIVTDIV.................
A0A091HZF9_CALAN/38-132                ......DDESD.NFDVDCFSQLEFQSSYSRLTCN.FTELPP.HNTNYTLALCSKED..RSYVCFKMEK.QEDGYFLQFTD--ILSNKYICMDSEMKKRMCRSLVVTDIV.................
D6RGV2_HUMAN/32-127                    ......DAELD.DYSFSCYSQLEVNGSQHSLTCA.FEDPDV.NITNLEFEICGAL-..VEVKCLNFRK.LQEIYFIETKKFLLIGKSNICVKVGEKSLTCKKIDLTTIV.................
D6RG28_HUMAN/32-59                     ......DAELD.DYSFSCYSQLEVNGSQHSLTCA.F-----.--------------..----------.----------------------------------------.................
A0A093CK76_9AVES/38-132                ......DDEQD.NFDIDCFSQLEFKDSYSSLTCN.FTELPP.HNTNYTLALCTKED..SNYVCFDMEK.QEDVYFLQFSD--ILSNKDICMFSKMKRRVCKSLIVTDIV.................
H2PFB9_PONAB/32-127                    ......DAELD.DYSFSCYSQLEVNGSQHSLTCA.FEDTDV.NITNLEFEICGAL-..VEVKCLNFRK.LQEIYFIETKKFLLIGKSNICVKVGEKSLTCKKIDLTTIV.................
A0A1U7QZS9_MESAU/32-93                 ......DAEPD.DYSFWCYSQLEVDGNQHSLTCA.FEDPDI.NSTNLEIEICAIH-..IKTLSASVEK.----------------------------------------selslr...........
A0A091VN94_NIPNI/38-132                ......DDEPD.NFDIDCFSQLEFKDSYSSLTCN.FTELPP.HNTNYTLALCTKED..SNYVCFNMEK.QEDAYFLQFTD--ILSKKYICMDSEMKRRACRSLIVTEIV.................
G3RFX0_GORGO/32-127                    ......DAELD.DYSFSCYSQLEVNGSQHSLTCA.FEDPDV.NTTNLEFEICGAL-..VEVKCLNFRK.LQEIYFIETKKFLLIGKSNICVKVGEKSLTCKKIDLTTIV.................
A0A093F7X7_TYTAL/35-129                ......DDEPD.NFDIDCFSQLEFKDSYSSLTCN.FTEPPP.HNTNYTLALCTKED..GNYVCFNMEK.QEDAYFLQFTD--ILSNKDICMDSETRRRVCRSLVVTDIV.................
G1S1H3_NOMLE/32-127                    ......DAELD.DYSFSCYSQLEVNGSQHSLTCA.FEDPDV.NTTNLEFEICGAL-..VEVKCLNFRK.LQEIYFIETKKFLLIGKSNICVKAGEKSLTCKKIDLTTIV.................
A0A087VA68_BALRE/38-132                ......DDETD.NFDIDCFSQLEFKDSYSSLTCN.FTELPS.HNTNYTLALCTKED..SNSVCFDMEK.QEDVYFLQFTD--ILSNKYICTGSEMKKRVCRSLVVTDIV.................
S7PLB5_MYOBR/31-126                    .....eDAEPD.-YSFSCYSQLEVDGSQHLLSCA.FDDPDV.NSTHLEFEICDGL-..LVVGCLNFIK.LQEIYFIKTNKFLLIGDSKICVKLGQRILTCRKMSIVHIV.................
A0A091EI26_CORBR/38-132                ......DDEPD.NFDIDCFSQLEIKDSFSSLTCN.FTELPP.YNTNYTLSLCTKED..NNYACSNMKK.QEDAFFLQFND--ILSNRDVCMYSETKRRVCRSLVVTDIV.................
M3WAZ4_FELCA/32-127                    ......DAELD.DYPFSCYSQLEVDGSQHLLTCT.FDDPDV.NSTNLEFEICGAL-..LDVKCLTFNK.MQEMYFIRTKKFLLIGDSEICVKLKGKKITCRKMNVVKIV.................
A0A0Q3TEB0_AMAAE/35-129                ......DDEPD.NLDIECFSQLEFKDSYSSLTCN.FTELPP.HNTNYTLALCTKED..SNYVCFNMEK.QEDVYFLQFTD--ILSNKYICMDSEMKRRVCRSLVVTDIV.................
A0A091QIR5_MERNU/38-132                ......DDESD.NFDVDCFSQLEFRDSYSSLTCN.FTELPL.HNTNYTLSLCTKED..SNYLCFNMEK.RQDVYFLQFMD--ILTNKDICMDSETKRRVCRNLVVTDIV.................
G1T184_RABIT/32-127                    ......DAEVD.EYSFSCYSQLEVDGFQHSLTCA.FDDPDA.NSTNLEFEICGAL-..LRVKCLNFSK.LQELYFIKTKNFLLIGDSKICVKLGKKNLICKEIDITKIV.................
IL7RA_CALJA/32-127                     ......DAELD.DYSFSCYSQLEVNGSQHSLTCA.FEDPDV.NTTNLEFEICGAL-..VEVRCLNFRK.LQEIYLIETKKFLLIGNSNICVKAGEKSLTCKNVNVATIV.................
A0A1L8HRT3_XENLA/1-98                  deevda---ET.NVDFSCFTKLRISKS-SFLICN.VTTQRPqNSWQYQLRVCQVDNsaNISKCIDMKK.EQGVYFVPSPM----DTYNVCLTKPGMNDSCRYYQAKDIV.................
A0A091GC95_9AVES/38-132                ......DDEPD.NFDINCFSQLEFKGSYSSLTCN.FTELSP.HNTNYTLSLCTKED..SNNVCFNMEK.QEDAYFLQFVD--ILSKKAICMDSETKRRVCRSLVVTDIV.................
IL7RA_MOUSE/32-127                     ......DADAD.DHSFWCHSQLEVDGSQHLLTCA.FNDSDI.NTANLEFQICGAL-..LRVKCLTLNK.LQDIYFIKTSEFLLIGSSNICVKLGQKNLTCKNMAINTIV.................
#=GR IL7RA_MOUSE/32-127          SS    ......XXXXX.X--EEEEEESSSSSS-EEEEEE.ES-TTS.--TTEEEEEESSB-..SS-SEEE-EE.ETTEEEEEES-B-SSS-EEEEEEETTEEEEEEEE-GGGSE.................
A0A091JVX0_COLST/38-132                ......DDESD.SFDTDCFSQLEFKDSYSSLTCN.FTEMEP.HNTNFTLALCTKED..GNYLCFDMEK.QEDVYFLQFTD--ILSNKHICMYAEMKRKLCKSLVVTDIV.................
IL7RA_HORSE/32-127                     ......DAELD.DYSFSCYSQLEVDGPQHLLSCA.FEDPDV.NSTNLEFEICEGL-..LEVKCLNFSK.LQETYFIKTKKFLLIGDSTICVKLGGKHITCQKLNIVKR-v................
A0A1V4KDC2_PATFA/35-129                ......DDEPD.NFDINCFSQLEFKDSYSSLTCN.FIELPP.DNTNYTLALCNKED..SNYMCFNMEK.REDVYFLQFTD--ILSNKDICMDFETKRRVCRSLVVTDMV.................
A0A091M0M7_CARIC/38-132                ......DDEPD.NFDIDCFSQLEFKDSYSSLTCN.FTKMPP.HNTNYTLTLCTKED..SNYVCFNMEK.QEDMYFLQFTD--ILSNKEICMDSEMKRRVCRSLVVTDIV.................
A0A151MWT0_ALLMI/38-132                ......DDELD.NPEIDCFSQLEIVSSLHALICS.FSEPSL.NNTNFQIVSCISEE..RIEKCSQMKK.QESTYSLEFSQ--ILLPRRVCVILESKRKYCSSLKVISIV.................
A0A091P3W8_LEPDC/38-132                ......DDEPD.NFDIDCFSQLEFKDFYSSLTCN.FTELPP.HNTNYTLALCNKED..SNYVCLNMEK.QEDVYFLQFTD--ILSNKDICMDSEMKRRICRSLVVTDIV.................
F7DGM3_HORSE/32-127                    ......DAELD.DYSFSCYSQLEVDGPQHLLSCA.FEDPDV.NSTNLEFEICEGL-..LEVKCLNFSK.LQETYFIKTKKFLLIGDSTICVKLGGKHITCQKLNIVKR-v................
A0A087RDI7_APTFO/38-132                ......DDEPD.NFDIDCFSQLEFRDSYSSLTCN.FTEPPP.HNTNYTLALCTKED..SNYVCFNMEK.QEDAYFLQFTD--ILSNKDICMDSEMKKRVCRSLVVTDIV.................
A0A093H3E6_GAVST/38-132                ......DDEPD.NFDIDCFSQLEFKDSYSSLTCN.FTELPP.PNTNYTLALCTKED..RNYVCFNMEK.QEDAYFLQFTD--ILSNKEICMDSETKRRVCRSLVVTDIV.................
A0A2I3MFR4_PAPAN/32-127                ......DAELD.DYSFSCYSQLEVNGSQHSLTCA.FEDPDV.NTTNLEFEICGAL-..VEVKCLSFRK.LQEIYFIETKKFLLIGKSNICVKVGGKSLTCKKIDLTTIV.................
A0A2I0LR56_COLLI/35-129                ......DDEPD.NFDINCFSQLEFKDSYSSLTCN.FIELPP.DNTNYTLALCNKED..SNYVCFNMEK.REDAYFLQFTD--ILSNKDICMDSETKRRVCRSLVVTDMV.................
A0A091S731_NESNO/38-132                ......DDEPD.NLDIECFSQLEFKDSYSSLTCN.FTELPP.HNTNYTLALCTKED..SNYVCFNMEK.QEDVYFLQFTD--ILSNKYICMDSEIKRRVCRSLVVTDIV.................
A0A226NGD7_CALSU/1511-1605             ......DDEPD.AFDIDCFSQLEFKDSYSSLTCN.FTELPL.HNTDYTLAVCTKED..CSHLCFNMEK.QEDVYFLQFTD--ILSNKDICVEYEIKRRFCKSLIVTDIV.................
A0A151MWX7_ALLMI/38-132                ......DDELD.NPEIDCFSQLEIVSSLHALICS.FSEPSL.NNTNFQIVSCISEE..RIEKCSQMKK.QESTYSLEFSQ--ILLPRRVCVILESKRKYCSSLKVISIV.................
A0A2K5K5D4_COLAP/32-127                ......DAELD.DYSFSCYSQLEVNGSQHSLTCA.FEDPDV.NTTNLEFEICGAL-..VEVKCLSFRK.LQEIYFIETKKFLLIGKSNICVKVGGKSLTCKKIDLTTIV.................
A0A093J883_EURHL/38-132                ......DDETD.SFDIDCFSQLEFKDSYSSLTCN.FTELPP.HNTNYTLALCNKED..SNYVCFNMEK.QEDVYFLQFTD--ILSNKDICMDSETKRRVCRSLVVTDIV.................
G3VXC3_SARHA/31-127                    ......DEEQD.DYDFTCYSQLQVYGQQHTLTCS.FNDSSV.NSTYLELKLCDAFM..SDSRCEIMMK.REKDYFIQSRSFSLIKSCKMCVIFRKSKMNCKTLKITKIV.................
A0A1S3FCR3_DIPOR/32-127                ......DAELD.DYSFWCYSQLEVDGAQHSLTCT.FNDPDI.NSTNLEMEICGAL-..MHVNCLSLNK.MQKMYFLKTKRFLLIGESRICVKLGEKSIYCKIFDIVKIV.................
G1PEK7_MYOLU/31-126                    .....eDAEPD.-YAFSCYSQLEVDGSQHLLSCA.FDDPDV.NSTHLEFEICDAL-..LVVGCLNFIK.LQEIYFIKTNKFLLIGDSKICVKLGQRILTCRKMSIVHIV.................
A0A2K5K5C9_COLAP/32-127                ......DAELD.DYSFSCYSQLEVNGSQHSLTCA.FEDPDV.NTTNLEFEICGAL-..VEVKCLSFRK.LQEIYFIETKKFLLIGKSNICVKVGGKSLTCKKIDLTTIV.................
A0A0D9RWV1_CHLSB/32-127                ......DAELD.DYSFSCYSQLEVNGSQHSLTCA.FEDPDV.NTTNLEFEICGAL-..VEVKCLSFRK.LQEIYFIETKKFLLIGKSNICVKVGGKSLTCKKIDLTTIV.................
A0A093SZ80_9PASS/38-132                ......DDEPD.NFDIDCFSQLDIKDPFSSLTCN.FTELPP.HNTNYTLSLCTKED..NKYMCNNMKK.QEDAYFLQFTD--ILSNRDLCVFSETKRRVCRSLVVTHIV.................
B8YG18_HUMAN/32-127                    ......DAELD.DYSFSCYSQLEVNGSQHSLTCA.FEDPDV.NITNLEFEICGAL-..VEVKCLNFRK.LQEIYFIETKKFLLIGKSNICVKVGEKSLTCKKIDLTTIV.................
A0A091XYH3_OPIHO/38-132                ......DDEPD.NLDIDCFSQLEFKDSYSSLTCN.FTELPP.HNTNDTLALCTKED..SNYVCFNMEK.QEDAYFLQFTD--ILSNKVICMDSETKRRVCRSLVVTDIV.................
A0A218UVK6_9PASE/101-195               ......DDEPD.NFDIDCFSQLEIKDSFSSLTCN.FTELSP.YNTNYTLSLCTKED..NNYACSNMKK.QEDVFFLQFID--ILSNRDVCMYSETKRRVCRSLVVTDIV.................
A0A1D5QDM4_MACMU/32-127                ......DAELD.DYSFSCYSQLEVNGSQHSLTCA.FEDPDV.NTTNLEFEICGAL-..VEVKCLSFRK.LQEIYFIETKKFLLIGKSNICVKVGGKSLTCKKIDLTTIV.................
H2QQR6_PANTR/32-127                    ......DAELD.DYSFSCYSQLEVNGSQHSLTCA.FEDPDV.NTTNLEFEICGAL-..VEVKCLNFRK.LQEIYFIETKKFLLIGKSNICVKVGEKSLTCKKIDLTTIV.................
A0A093RJ38_PYGAD/38-132                ......DDEPD.NFDIDCFSQLEFRDSYSSLTCN.FTEPPP.HNTNYTLALCTKED..SNYMCFNMEK.QEDAYFLQFTD--ILSNKDICMDSEMKKRVCRSLVVTDIV.................
A0A226PGG9_COLVI/35-129                ......DDEPD.AFDFDCFSQLEFKDSYSSLTCN.FTELPL.HNTDYTLVVCTKED..SSHLCLNMEK.QEDVYFLQFTD--ILSNKDICVEYEMKRKFCKSLIVTDIV.................
L9JTG1_TUPCH/1584-1679                 ......DAEPD.DYSFSCYSQLEVNGPQHTLTCA.FDDPDV.NSTNLDFEICKNL-..VGVECLHLSK.LQDRYFLRTKKFLLVGDSKICVKLGDKKITCKNINIVEIV.................
A0A091LCP5_CATAU/38-132                ......DDEPD.NFDIDCFSQLEFKDSYSSLTCN.FTELPP.HHTNYTLALCTKED..SNYVCFDMEK.QEDTYFLQFTD--ILSNKDICMDSETKRRVCRSLVVTDIV.................
F7A0L8_ORNAN/32-128                    ......DEELE.NYDFSCFSQLQVDGSKHTLTCS.FEDSTL.DQANLKIELCGKFL..NENSCQPLEK.PGGVYFLKTNAISLIGSCTLCAILEKKRKNCKVMTITKIV.................
G3VXC4_SARHA/31-127                    ......DEEQD.DYDFTCYSQLQVYGQQHTLTCS.FNDSSV.NSTYLELKLCDAFM..SDSRCEIMMK.REKDYFIQSRSFSLIKSCKMCVIFRKSKMNCKTLKITKIV.................
A0A1A6GX46_NEOLE/41-136                ......DAEPD.DYSFWCYSQLEVDGNQHSLTCA.FDDPYI.NSTNLELQICGAL-..IEMECLTLNK.LQETYFIKTGKFLLIGTSTICVKLGKKNLICKNVDIAKIV.................
A0A1U7TCP5_TARSY/32-127                ......DAESD.DYSFSCYSQLEVSGSEHSLTCA.LNDPEV.NTTNVQLEICDAL-..LEVKCLNLSK.LQDIYFIKTKKFLLIGPSKICVKPGKDDMHCKTMNIVDIV.................
A0A091MWY5_9PASS/38-132                ......DDEPD.NFDIDCFSQLEFKDSLSSLTCN.FTELPP.HNTNYTLSLCTKED..RNYMCFNMEK.QEDAYFLEFTD--ILSNTDICMDSEAKRRVCRRLVVTDIV.................
M3YUE3_MUSPF/32-127                    ......DAELD.DYSFSCYSQLEVDGTQHLLTCA.FDDPDV.NTTNLELEICGAL-..LNVKCLTFDK.LHEMYFIKTKKFLLIGDSEIHVKLGGKNITFKKLNIVKIV.................
G3HKG1_CRIGR/20-80                     ......DAEPDaDYSFGCYSQLEVDGNQHSLTCA.FDDPDI.NSTNLELQIW----..----------.----------------------------------------ikpivwpslpdhkktle
A0A2I3SFV9_PANTR/32-127                ......DAELD.DYSFSCYSQLEVNGSQHSLTCA.FEDPDV.NTTNLEFEICGAL-..VEVKCLNFRK.LQEIYFIETKKFLLIGKSNICVKVGEKSLTCKKIDLTTIV.................
A0A091RAC7_9GRUI/37-131                ......DDEPD.SLDIDCFSQLEFKDSYSSLTCN.FTELPP.HNTNYTLALCTKED..SNYVCFNMKK.REEAYFLQFTD--ILSKKYVCMNIEMKRRVCRSLVVTDIV.................
A0A091KTQ5_9GRUI/38-132                ......DDEPD.NFDIDCFSQLEFKDSYSTLTCN.FTELPP.HNTNYTLALCTKED..SNYVCFNMEK.QEDAYFLQFTD--ILSNKDICMDSETKRRVCRSVVVTDIV.................
A0A093HNN9_STRCA/37-131                ......DDEPD.NLDINCFSQLEFKDSYSSLTCN.LTELPP.HNTNYILAVCTKED..RNYVCSNMEK.QEDAYFLQFTD--ILSNRDVCMDSGIKRKICRSLIVTDIV.................
#=GC SS_cons                           ......XXXGG.GG-EEEEEECCCCTTEEEEEEE.ESSTTS.SSTTEEEEEESSB-..SSSSEEE-EE.ETTEEEEEES-B-SSSEEEEEEEETTEEEEEEEEEGGGSE.................
#=GC seq_cons                          ......DsE.D.sashsCaSQLElcsS.pSLTCs.Fs-sss.psTNhphplCst....sphhChshcK..p-hYFlphpc..lluspsICVchttKphsC+plslTcIV.................
//
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