GenomeNet

Database: Pfam
Entry: Flavi_capsid
LinkDB: Flavi_capsid
Original site: Flavi_capsid 
#=GF ID   Flavi_capsid
#=GF AC   PF01003.21
#=GF DE   Flavivirus capsid protein C
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_156 (release 3.0)  
#=GF GA   21.00 21.00;
#=GF TC   21.60 94.00;
#=GF NC   20.90 20.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   9499070
#=GF RT   Signal peptidase cleavage at the flavivirus C-prM junction:
#=GF RT   dependence on the viral NS2B-3 protease for efficient processing
#=GF RT   requires determinants in C, the signal peptide, and prM. 
#=GF RA   Stocks CE, Lobigs M; 
#=GF RL   J Virol 1998;72:2141-2149.
#=GF RN   [2]
#=GF RM   9201220
#=GF RT   A conserved internal hydrophobic domain mediates the stable
#=GF RT   membrane integration of the dengue virus capsid protein. 
#=GF RA   Markoff L, Falgout B, Chang A; 
#=GF RL   Virology 1997;233:105-117.
#=GF DR   INTERPRO; IPR001122;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Flaviviruses are small enveloped viruses with virions comprised
#=GF CC   of 3 proteins called C, M and E.  Multiple copies of the C
#=GF CC   protein  form the nucleocapsid, which contains the ssRNA
#=GF CC   molecule.
#=GF SQ   3
#=GS POLG_ZIKV/6-123   AC Q32ZE1.1
#=GS POLG_ZIKV/6-123   DR PDB; 5Z0V B; 371-445;
#=GS POLG_ZIKV/6-123   DR PDB; 5Z0R B; 371-445;
#=GS POLG_ZIKV/6-123   DR PDB; 5Z0V C; 371-445;
#=GS POLG_ZIKV/6-123   DR PDB; 5Z0V D; 371-445;
#=GS POLG_ZIKV/6-123   DR PDB; 5Z0V A; 371-445;
#=GS POLG_ZIKV/6-123   DR PDB; 5Z0R A; 371-445;
#=GS POLG_YEFV1/5-122  AC P03314.1
#=GS POLG_DEN1W/5-117  AC P17763.2
POLG_ZIKV/6-123              eeirr-----IRIVNMLKRGVARV.nPLGGLKRLPAGLLLGHGPIRMVLAILAFLR...FTAIKPSLGLINRWGSVGKKEAMEIIKKFKKDLAAMLRIINARKERKRRGADTSIGIIGL-LLTTAMAa....
#=GR POLG_ZIKV/6-123   SS    XXXXX-----XXXXXXXXXXXXXH.GGGTS-SSS-TTGGGT-S-HHHHHHHHHHHH...HTT----HHHHHHHHHS-HHHHHHHHHHHHHHHHHHHHHHHT-XXXXXXXXXXXXXXXXX-XXXXXXXX....
POLG_YEFV1/5-122             .....KAQGKTLGVNMVRRGVRSL..-SNKIKQKTKQIGNRPGPSRGVQGFIFFFLfniLTGKKITAHLKRLWKMLDPRQGLAVLRKVKRVVASLMRGLSSRKRRSHDVLTVQFLILGM--LLM---tggv.
POLG_DEN1W/5-117             ....r-KKTGRPSFNMLKRARNRVstVSQLAKRFSKGLLSGQGPMKLVMAFIAFLR...FLAIPPTAGILARWGSFKKNGAIKVLRGFKKEISNMLNIMNRRKRS-------VTMLLML--LPTA--lafhl
#=GC SS_cons                 XXXXX-----XXXXXXXXXXXXXH.GGGTS-SSS-TTGGGT-S-HHHHHHHHHHHH...HTT----HHHHHHHHHS-HHHHHHHHHHHHHHHHHHHHHHHT-XXXXXXXXXXXXXXXXX-XXXXXXXX....
#=GC seq_cons                ....R.tpstphuVNMLKRGVsRV.ssSstlKRhoKGLLsGpGPhRhVhAFIAFLR...FTAIKPTAGLlsRWGSlcK+pAlcVLRKFKK-lAuMLRIlNuRKRRp+cshssshhILGL..LsTA..suhh.
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