#=GF ID Flu_B_NS1
#=GF AC PF02942.15
#=GF DE Influenza B non-structural protein (NS1)
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_198 (Release 6.4)
#=GF GA 25.00 25.00;
#=GF TC 26.10 516.20;
#=GF NC 21.70 20.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 11157743
#=GF RT Influenza B virus NS1 protein inhibits conjugation of the
#=GF RT interferon (IFN)-induced ubiquitin-like ISG15 protein.
#=GF RA Yuan W, Krug RM;
#=GF RL EMBO J 2001;20:362-371.
#=GF DR INTERPRO; IPR004208;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC A specific region of the influenza B virus NS1 protein, which
#=GF CC includes part of its effector domain, blocks the covalent
#=GF CC linkage of ISG15 Swiss:Q64339 to its target proteins both in
#=GF CC vitro and in infected cells. Of the several hundred proteins
#=GF CC induced by interferon (IFN) alpha/beta, the ubiquitin-like ISG15
#=GF CC protein is one of the most predominant. Influenza A virus
#=GF CC employs a different strategy: its NS1 protein does not bind the
#=GF CC ISG15 protein, but little or no ISG15 protein is produced during
#=GF CC infection [1].
#=GF SQ 3
#=GS A0A140EUI3_9INFB/1-247 AC A0A140EUI3.1
#=GS NS1_INBLE/1-247 AC P03502.1
#=GS NS1_INBLE/1-247 DR PDB; 6JH1 A; 9-100;
#=GS NS1_INBLE/1-247 DR PDB; 3SDL A; 7-101;
#=GS NS1_INBLE/1-247 DR PDB; 1XEQ A; 15-103;
#=GS NS1_INBLE/1-247 DR PDB; 6JH0 A; 9-102;
#=GS NS1_INBLE/1-247 DR PDB; 1XEQ B; 9-93;
#=GS NS1_INBLE/1-247 DR PDB; 3R66 B; 7-102;
#=GS NS1_INBLE/1-247 DR PDB; 3RT3 C; 9-102;
#=GS NS1_INBLE/1-247 DR PDB; 6JH1 B; 9-99;
#=GS NS1_INBLE/1-247 DR PDB; 3R66 A; 7-102;
#=GS NS1_INBLE/1-247 DR PDB; 6JH0 C; 9-102;
#=GS NS1_INBLE/1-247 DR PDB; 3SDL B; 7-103;
#=GS A0A140EU62_9INFB/1-247 AC A0A140EU62.1
A0A140EUI3_9INFB/1-247 MADNMTTTQIEVGPGATNATINFEAGILECYERLSWQRALDYPGQDRLNRLKRKLESRIKTHNKSEPESKRMSLEERKAIGVKMMKVLLFMNPSAGIEGFEPYCMKSSSNSNCQKYNWTNYPSTPGRCLDDIEEEPDDVDGPTEIVLRDMNNKDARQKIKEEVNTQKEGKFRLTIKRDMRNVLSLRVLVNGTFLKHPNGYKSLSTLHRLNAYDQSGRLVAKLVATDDLTVEDEEDGHRILNSLFERL
NS1_INBLE/1-247 MADNMTTTQIEVGPGATNATINFEAGILECYERFSWQRALDYPGQDRLHRLKRKLESRIKTHNKSEPENKRMSLEERKAIGVKMMKVLLFMDPSAGIEGFEPYCVKNPSTSKCPNYDWTDYPPTPGKYLDDIEEEPENVDHPIEVVLRDMNNKDARQKIKDEVNTQKEGKFRLTIKRDIRNVLSLRVLVNGTFLKHPNGDKSLSTLHRLNAYDQNGGLVAKLVATDDRTVEDEKDGHRILNSLFERF
#=GR NS1_INBLE/1-247 SS XXXXXX---TT--TTHHHHHHHHHHHHHHHHHHHHHTT-S-HHHHHHHHHHHHHHHHHHHHHHHTS-GGG---HHHHHHHHHHHHHHHHHT-GGGTGGGG---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
A0A140EU62_9INFB/1-247 MADNMTTTQIEVGPGATNATINFEAGILECYERLSWQRALDYPGQDRLNRLKRKLESRIKTHNKSEPESKRMSLEERKAIGVKMMKVLLFMNPSAGIEGFEPYCMKSSSNSNCQKYNWTNYPSTPGRCLDDIEEEPDDVDGPTEIVLRDMNNKDARQKIKEEVNTQKEGKFRLTIKRDMRNVLSLRVLVNGTFLKHPNGYKSLSTLHRLNAYDQSGRLVAKLVATDDLTVEDEEDGHRILNSLFERL
#=GC SS_cons XXXXXX---TT--TTHHHHHHHHHHHHHHHHHHHHHTT-S-HHHHHHHHHHHHHHHHHHHHHHHTS-GGG---HHHHHHHHHHHHHHHHHT-GGGTGGGG---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
#=GC seq_cons MADNMTTTQIEVGPGATNATINFEAGILECYERLSWQRALDYPGQDRLNRLKRKLESRIKTHNKSEPESKRMSLEERKAIGVKMMKVLLFMNPSAGIEGFEPYCMKSSSNSNCQKYNWTNYPSTPGRCLDDIEEEPDDVDGPTEIVLRDMNNKDARQKIKEEVNTQKEGKFRLTIKRDMRNVLSLRVLVNGTFLKHPNGYKSLSTLHRLNAYDQSGRLVAKLVATDDLTVEDEEDGHRILNSLFERL
//
