GenomeNet

Database: Pfam
Entry: Fve
LinkDB: Fve
Original site: Fve 
#=GF ID   Fve
#=GF AC   PF09259.13
#=GF DE   Fungal immunomodulatory protein Fve
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   pdb_1osy
#=GF GA   25.00 25.00;
#=GF TC   36.00 25.20;
#=GF NC   24.10 18.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   12948495
#=GF RT   A 1.7A structure of Fve, a member of the new fungal
#=GF RT   immunomodulatory protein family. 
#=GF RA   Paaventhan P, Joseph JS, Seow SV, Vaday S, Robinson H, Chua KY,
#=GF RA   Kolatkar PR; 
#=GF RL   J Mol Biol. 2003;332:461-470.
#=GF DR   INTERPRO; IPR015339;
#=GF DR   SCOP; 1osy; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Fve is a major fruiting body protein from Flammulina velutipes,
#=GF CC   a mushroom possessing immunomodulatory activity. It stimulates
#=GF CC   lymphocyte mitogenesis, suppresses systemic anaphylaxis
#=GF CC   reactions and oedema, enhances transcription of IL-2, IFN-gamma
#=GF CC   and TNF-alpha, and haemagglutinates red blood cells. It appears
#=GF CC   to be a lectin with specificity for complex cell-surface
#=GF CC   carbohydrates. Fve adopts a tertiary structure consisting of an
#=GF CC   immunoglobulin-like beta-sandwich, with seven strands arranged
#=GF CC   in two beta sheets, in a Greek-key topology. It forms a
#=GF CC   non-covalently linked homodimer containing no Cys, His or Met
#=GF CC   residues; dimerisation occurs by 3-D domain swapping of the
#=GF CC   N-terminal helices and is stabilised predominantly by
#=GF CC   hydrophobic interactions [1].
#=GF SQ   34
#=GS A0A067MEZ4_9AGAM/4-111    AC A0A067MEZ4.1
#=GS A0A4Q9MD29_9APHY/2-110    AC A0A4Q9MD29.1
#=GS C7ZE17_NECH7/5-113        AC C7ZE17.1
#=GS A0A4Q9Q1W7_9APHY/6-114    AC A0A4Q9Q1W7.1
#=GS A0A0C2WQ98_AMAMU/6-113    AC A0A0C2WQ98.1
#=GS A0A5C3PJM5_9APHY/3-111    AC A0A5C3PJM5.1
#=GS A0A0D2Q4N7_HYPSF/462-551  AC A0A0D2Q4N7.1
#=GS K5W7W1_PHACS/41-71        AC K5W7W1.1
#=GS A0A428TVZ6_9HYPO/30-138   AC A0A428TVZ6.1
#=GS A0A0C2WK68_AMAMU/6-113    AC A0A0C2WK68.1
#=GS A0A428QTC5_9HYPO/408-516  AC A0A428QTC5.1
#=GS A0A5C2SJP9_9APHY/3-111    AC A0A5C2SJP9.1
#=GS A0A4S4N9A7_9APHY/442-538  AC A0A4S4N9A7.1
#=GS M2QVQ0_CERS8/4-101        AC M2QVQ0.1
#=GS M2PWI3_CERS8/37-130       AC M2PWI3.1
#=GS A0A2G8RV27_9APHY/2-110    AC A0A2G8RV27.1
#=GS A0A5C3P6D3_9APHY/2-111    AC A0A5C3P6D3.1
#=GS A0A0D2Q4N7_HYPSF/347-442  AC A0A0D2Q4N7.1
#=GS A0A371D6G4_9APHY/3-111    AC A0A371D6G4.1
#=GS M2R9U0_CERS8/4-78         AC M2R9U0.1
#=GS A0A1M2V762_TRAPU/3-111    AC A0A1M2V762.1
#=GS A0A0C2WMX8_AMAMU/6-113    AC A0A0C2WMX8.1
#=GS K5W7W1_PHACS/4-44         AC K5W7W1.1
#=GS A0A1Y2IY48_PYCCO/131-240  AC A0A1Y2IY48.1
#=GS A0A5C2SS06_9APHY/3-111    AC A0A5C2SS06.1
#=GS A0A1M2V769_TRAPU/9-118    AC A0A1M2V769.1
#=GS A0A4Y7Q2V5_9AGAM/3-103    AC A0A4Y7Q2V5.1
#=GS A0A4R0RG39_9APHY/527-621  AC A0A4R0RG39.1
#=GS A0A3M2SLJ9_9HYPO/5-113    AC A0A3M2SLJ9.1
#=GS A0A0H2SFW9_9AGAM/561-660  AC A0A0H2SFW9.1
#=GS A0A084QD05_STAC4/3-111    AC A0A084QD05.1
#=GS A0A428P1G9_9HYPO/5-113    AC A0A428P1G9.1
#=GS A0A1X6MNP6_9APHY/1-98     AC A0A1X6MNP6.1
#=GS A0A4Q9MVQ6_9APHY/5-111    AC A0A4Q9MVQ6.1
A0A067MEZ4_9AGAM/4-111               ............d-TTAQIFHLVASLPKLSYDYTPNWVK...D--RQ.YINSVTFAKVLADKAYTYRVMAGDKDLGVKPSYAVGSDGSQKINFLEYNGGYGIDgNANTVYVYVVDPETGN.--QYKIAQ-s.............
A0A4Q9MD29_9APHY/2-110               ............v-DTSVLLALAAQHQRVHFDYTPAWGR...GSPAS.YVDNVTFPHVLDDKAYQYRVIVGDKDLGLRKSYSIQPDGSQKVNFLEYNGGYGIA.DSNRIRVYVVDPESGN.--QYLIAQW..............
C7ZE17_NECH7/5-113                   ............n-DSAVLFYIVASQKKLSFDYTPNWGR...GSPNS.YIDNLTFPRVLTNKPYKYRVVKAGQDLGVRDSYSVQSDGSQKVNFLEYNAGRGIA.DTQTIQVYVVDPDNGN.--QYLVAQW..............
A0A4Q9Q1W7_9APHY/6-114               ............n-NTAITFALVWAEKKLTFDYTPNWVR...GHPSS.YVDNVVFPKVLTDKKYSYRVLVSGKDLGVRDGYSVQSDGSQKVNFLEYNAGRGIA.DSNTIQVYAVDPDDGN.--NYLVAQ-c.............
A0A0C2WQ98_AMAMU/6-113               ...........tn--EALAFLLVSQIKKIHFDYTPNYYR...PMP-G.FTDAVTFPKVLADKAYEYQVIVDGVSKGIRRDYSVAPDGSQKVNFLGYNEGHGIL.NSSNTQVYVVDPETNI.-AYYI----ltv...........
A0A5C3PJM5_9APHY/3-111               ..........dqt---DSIFAVIAKNPALCFDYNPRWGR...GNPRS.YIDNVTFPKVMTTKNFKYRVVADESDFGVRDAYGVQSDGSQKLNFLDWNAQHGIA.DSKTIKVYSVDPDSGN.--QYLVARW..............
A0A0D2Q4N7_HYPSF/462-551             ......aggirwt--------------------------...-TDSS.LVLSVSINHVLNNKDYMLRIMRDGADLGVHPAGPLTADKTLNIDLTKYNDGQGLP.VQSLIKVLVVDPDAR-.---------glgtlvsgw.....
K5W7W1_PHACS/41-71                   ...........lp--------------------------...-----.-------------------------------------------------KGYGVE.QGSTIQIYAVDPDDGN.--QYLIARW..............
A0A428TVZ6_9HYPO/30-138              ............n-DSAILFYLVASHKKLNFDYTPNWGR...GSPNS.YIDNLTFPRVLTNKPYKYRVVKAGQDLGVRDSYSVQSDGSQKVNFLEYNAGRGIA.DTQTIQVYVVDPDNGN.--QYLVAQW..............
A0A0C2WK68_AMAMU/6-113               ..........vne---GLVFLLVSQVKKIDFDYTPHYYR...PT-SG.YTDAVTFPKVLANKAYKYQVVVDGVSKGIRRDHAVAPDGSQKINFLDYNAGYGIP.NKSSTQVYAVDPDTGI.-AYYI----ltv...........
A0A428QTC5_9HYPO/408-516             ............n-DSAILFYLVASHKKLNFDYTPNWGR...GSPNS.YIDNLTFPRVLTNKPYKYRVVKAGQDLGVRDSYSVQSDGSQKVNFLEYNAGRGIA.DTQTIQVYVVDPDNGN.--QYLVAQW..............
A0A5C2SJP9_9APHY/3-111               ...........dl--TGFIFSLIEQVPVLDLDYTPRWGR...GNPSQ.YIDNVTFKKVLTTKKWMYRIVKGGDDLGVQAGYTVESDGAHRVNFLAYNAGHGIM.DTLSILVYVVDPDNGN.--QFLVAKW..............
A0A4S4N9A7_9APHY/442-538             ......wrsmvet-------------------HKPRWTR...GNPPN.YIDAVKFPRVLKDKPYQYRVVRGEDDLGIKPSYEIQTDDSQTVNLLEYNSGYGVS.DRIPIQVFAVDPEDKG.--ETLVAQW..............
M2QVQ0_CERS8/4-101                   ....ewvklvrtn--------------------SATWKR...GNPKV.YFDHVTLPGVPTDKAYQYRVVKGDLDLGTRPTYELNKDGSQTINLLEYNKGYGIH.EETPINVFVVDPEDGM.--ETLVAEW..............
M2PWI3_CERS8/37-130                  ......lnartpt----------------------IWKR...GNPTD.YVDHVTLPRVPADKIYQCRVMKSNLDLGIQPTHPLNEDGSQTINLTEYNKRYGIH.DTQNIKVYVIDPADNT.--EKPVAKW..............
A0A2G8RV27_9APHY/2-110               .............SDTALIFRLAWDVKKLSFDYTPTWGR...GNPSR.FVDNVTFPQVLADKAYTYRVVVSGRDLGVRPSYAVGSDGSQKVNFLEYNQGYGIA.DTNTIQVFVIDPDTDA.--DFIIAQW..............
A0A5C3P6D3_9APHY/2-111               ..........sdq--SALIFALIPQTKKESWDYTANYGR...GSPSS.YIDNITFPKVLADKKYQYRVVAAGKDLGVRAGYTVQSDGSQKVNFLDYNAGGGIP.DSQTIKVYAVDPDSGN.--QYLVSQW..............
A0A0D2Q4N7_HYPSF/347-442             sivqafppqwkyv----------------------NWG-...--ARN.YVDEVTLPFVLIDKPYRYRVRSGISDLGIRETYELSADGSQRINFLEYNKGYGII.DSMHIKIFVVDPEGNE.---AL----vayw..........
A0A371D6G4_9APHY/3-111               ............d-QTGYIFALIEPVPVLSWDYTPNWGH...GNPSS.YIDNVTFKKVITLKDFEYRVVAGGKDLGVRAAYGVQSDGSQKVNFLEYNNGYGIA.DSQTIKVYTVDPDNGN.--QYLVAQW..............
M2R9U0_CERS8/4-78                    .........rasp---------------------PVWRR...GNPTI.YVDYVTIPHAPADKVCQYRVIKSGTDLGVRPTQPLNEDGSQTVKLRQ--------.----------------.---------cpalrnqnssfvqk
A0A1M2V762_TRAPU/3-111               ...........sp--SSILLHLVATLRKVHFDYTPQWKR...DASQK.NIIAVTFPRVLVDKRYSYRVVCEDNDLGIRRGTGPFAGGAETVNFLEYSHGSGIP.QTHRLRVYVVDPDTGN.--QYLVAQ-r.............
A0A0C2WMX8_AMAMU/6-113               ..........ane---GLAFLLVSQVKKIDFDYTPNYYR...PT-SG.YTDAVTFPKVLTDKAYEYKVVVDGVDKGTRRDFSVAPDGSQKVNFLAYNAGLGIP.TGSSIQVYAVDPNTGI.-AYYI----ltv...........
K5W7W1_PHACS/4-44                    ............s-SSAALFYLVQIMSRVCFDYTPDWQR...GNPNS.YIDMVKLPK----------------------------------------------.----------------.---------g.............
A0A1Y2IY48_PYCCO/131-240             ..........sds--SSMMLYLTSTMHTINIDYNPKWAR...GSPSS.FIDNVTFPRVLADKAYTYRVYKDDTDLGVRKSYAIQGDGSQKVNFLEYNKGHGIP.DSSTIRVYVIHPDTEN.--QYLVAKW..............
A0A5C2SS06_9APHY/3-111               ............d-STGIIFALIAQYKALCWDYTANWGR...GNPSS.YIDNITFKKVITTKNFKYRVVSAGNDLGVRDAYSVQSDGSQKVNFLDYNAGRGIE.DTKRIQVYVVDPDNGN.--QYLVAQW..............
A0A1M2V769_TRAPU/9-118               ..........att--ISLLLHLTSTLGKVHFDYTPHWGH...GHPNT.YIDNVTFPHVLTDKPYIYRVCMDDTDLGMQPALAVQSDGSQKLNFLQWNGGHGIP.QTHRIRVYVVDP--GN.AIQYLVALW..............
A0A4Y7Q2V5_9AGAM/3-103               ...........qp--------------HIDFDYTPKWTSvpwGRPGDfYINDVTFPKVLRDKPYKYHVFKGDEDLGVREPYEIRSDGSQTVNILEYHRGYGIL.ETNPIVIYLLDPDTEV.--EYKLTEW..............
A0A4R0RG39_9APHY/527-621             .......stvsah--------------------RPEWTR...GNPPV.FVDSVTFPQVLTDKPYTYRVVKGGEDLGVKPSYEVQQDGSQTVNLLEYNQGYGVH.ETTPVEVYAVDPDDER.--ETLVAEW..............
A0A3M2SLJ9_9HYPO/5-113               ............n-DSAILFYLVASHKKLNFDYTPNWGR...GSPNS.YIDNLTFPRVLTNKPYKYRVVKAGQDLGVRDSYSVQSDGSQKVNFLEYNAGRGIA.DTQTIQVYVVDPDNGN.--QYLVAQW..............
A0A0H2SFW9_9AGAM/561-660             .....waqslhla--------------------EPTWKR...GNPSI.YIDELTIPLLPSDKQYQYRVVKGDTDLGIKETYPREIGGSQRINLLEYNEGYGIQ.DTVPIKVYAVDPEEEEgNRETLVASW..............
A0A084QD05_STAC4/3-111               .........apty----LLVPFVTAVGKINVDYTPNWGR...GSPSS.YIDNVKFPRVLTDRQYKYRVVKGSTDLGVRDAYAIESDGSQKINFLEYNSGRGIE.DSTAIKIYIVEPDTGN.--QSLLVQW..............
A0A428P1G9_9HYPO/5-113               ............n-DSAILFYLVASHKKLNFDYTPNWGR...GSPNS.YIDNLTFPCVLTNKPYKYRVVKAGQDLGVRDSYSVQSDGSQKVNFLEYNAGRGIA.DTQTIQVYVVDPDNGN.--QYLVAQW..............
A0A1X6MNP6_9APHY/1-98                .............---------------VDFDYTPKWKRvewGAPGQfYLDEVTFPKVLKDKRYKYRVVSGSTDLGIREPYDVQADGSQRINFLEYNQGYGIR.DTNTVTVYLVDPETAT.--EY-----kltqs.........
A0A4Q9MVQ6_9APHY/5-111               ...........lt--TATIFALVWTQTKICFDYTPDWID...GGP-R.YINGVVFPKVLTDKNYSYRVE-SDRDYGVRAGYQVQADGSQKVNFLDYNYGLGIE.PYRGIKVYVVDPDDGK.--NYLVAE-l.............
#=GC seq_cons                        ............s...uhhhhlh.t..tlsaDYTPsWsR...GsPss.YlDsVTFP+VLsDKsYpYRVltuspDLGlRsuYslpuDGSQ+VNFLEYNtGhGIt.-opsIpVYlVDPDsGs...pYLlApW..............
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