GenomeNet

Database: Pfam
Entry: GARP
LinkDB: GARP
Original site: GARP 
#=GF ID   GARP
#=GF AC   PF16731.5
#=GF DE   Glutamic acid/alanine-rich protein of Trypanosoma
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   pdb_2y44
#=GF GA   27.40 27.40;
#=GF TC   27.40 27.60;
#=GF NC   27.10 27.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   21471223
#=GF RT   Structural characterization and epitope mapping of the glutamic
#=GF RT   acid/alanine-rich protein from Trypanosoma congolense: defining
#=GF RT   assembly on the parasite cell surface.
#=GF RA   Loveless BC, Mason JW, Sakurai T, Inoue N, Razavi M, Pearson TW,
#=GF RA   Boulanger MJ;
#=GF RL   J Biol Chem. 2011;286:20658-20665.
#=GF DR   INTERPRO; IPR031987;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   GARP, or glutamic acid/alanine-rich protein, is one of a subset
#=GF CC   of major surface molecules on Trypanosoma species.  They are all
#=GF CC   surface-orientated, immunodominant, and highly charged. GARP is
#=GF CC   interesting as ts expression coincides with the loss and gain of
#=GF CC   variant surface glycoprotein (VSG) molecules in the tsetse
#=GF CC   vector. It has an extended helical bundle structure that is
#=GF CC   homologous to the core surface structure of VSG, suggesting that
#=GF CC   it might replace the bloodstream VSG as the trypanosomes
#=GF CC   differentiate inside the tsetse vector after a blood-meal [1].
#=GF SQ   73
#=GS Q57YD8_TRYB2/27-218      AC Q57YD8.1
#=GS F9WIZ4_TRYCI/34-226      AC F9WIZ4.1
#=GS F9WA19_TRYCI/37-229      AC F9WA19.1
#=GS F9WV99_TRYVY/153-305     AC F9WV99.1
#=GS F9WVM2_TRYVY/600-805     AC F9WVM2.1
#=GS Q38CV9_TRYB2/38-223      AC Q38CV9.1
#=GS A0A1M6NIJ8_9CLOT/35-148  AC A0A1M6NIJ8.1
#=GS Q57XH8_TRYB2/239-429     AC Q57XH8.1
#=GS F9WEJ8_TRYCI/41-225      AC F9WEJ8.1
#=GS Q385U1_TRYB2/28-218      AC Q385U1.1
#=GS G5GGR6_9FIRM/37-165      AC G5GGR6.1
#=GS Q57X85_TRYB2/28-230      AC Q57X85.1
#=GS Q57XI0_TRYB2/239-418     AC Q57XI0.1
#=GS F9WM12_TRYVY/113-305     AC F9WM12.1
#=GS F9WN26_TRYVY/113-305     AC F9WN26.1
#=GS F9WMG2_TRYVY/606-799     AC F9WMG2.1
#=GS F9W3K3_TRYCI/27-147      AC F9W3K3.1
#=GS F9WP06_TRYVY/468-660     AC F9WP06.1
#=GS F9WE93_TRYCI/41-225      AC F9WE93.1
#=GS F9WN27_TRYVY/50-239      AC F9WN27.1
#=GS F9WUH5_TRYVY/604-795     AC F9WUH5.1
#=GS Q38CV6_TRYB2/38-223      AC Q38CV6.1
#=GS Q38CV7_TRYB2/38-224      AC Q38CV7.1
#=GS F9WQ61_TRYVY/144-278     AC F9WQ61.1
#=GS Q38CV8_TRYB2/38-223      AC Q38CV8.1
#=GS F9W3C7_TRYCI/41-225      AC F9W3C7.1
#=GS F9WRL8_TRYVY/59-271      AC F9WRL8.1
#=GS Q57U18_TRYB2/29-221      AC Q57U18.1
#=GS F9WUC1_TRYVY/259-401     AC F9WUC1.1
#=GS F9WA18_TRYCI/37-229      AC F9WA18.1
#=GS F9WE90_TRYCI/41-225      AC F9WE90.1
#=GS F9WH65_TRYCI/239-430     AC F9WH65.1
#=GS Q38CW0_TRYB2/38-223      AC Q38CW0.1
#=GS F9WM65_TRYVY/167-285     AC F9WM65.1
#=GS F9WV46_TRYVY/166-284     AC F9WV46.1
#=GS Q57XI0_TRYB2/27-218      AC Q57XI0.1
#=GS Q38CV2_TRYB2/38-223      AC Q38CV2.1
#=GS F9WVN8_TRYVY/75-289      AC F9WVN8.1
#=GS F9WQX1_TRYVY/63-253      AC F9WQX1.1
#=GS F9WKL8_TRYVY/86-292      AC F9WKL8.1
#=GS Q38CV4_TRYB2/38-225      AC Q38CV4.1
#=GS F9WC09_TRYCI/239-430     AC F9WC09.1
#=GS F9WC09_TRYCI/451-642     AC F9WC09.1
#=GS F9WRF2_TRYVY/70-259      AC F9WRF2.1
#=GS Q57U10_TRYB2/29-221      AC Q57U10.1
#=GS Q38CW1_TRYB2/38-223      AC Q38CW1.1
#=GS F9WC08_TRYCI/50-241      AC F9WC08.1
#=GS Q57U12_TRYB2/29-220      AC Q57U12.1
#=GS Q38CU9_TRYB2/38-223      AC Q38CU9.1
#=GS F9WE91_TRYCI/41-225      AC F9WE91.1
#=GS F9WQR4_TRYVY/166-284     AC F9WQR4.1
#=GS F9WH65_TRYCI/27-230      AC F9WH65.1
#=GS F9WV98_TRYVY/82-271      AC F9WV98.1
#=GS F9WTA4_TRYVY/603-782     AC F9WTA4.1
#=GS F9WDT3_TRYCI/37-229      AC F9WDT3.1
#=GS Q38CV3_TRYB2/38-223      AC Q38CV3.1
#=GS Q38CV1_TRYB2/38-223      AC Q38CV1.1
#=GS Q57Z47_TRYB2/32-225      AC Q57Z47.1
#=GS F9WUB1_TRYVY/36-256      AC F9WUB1.1
#=GS F9WK97_TRYVY/67-256      AC F9WK97.1
#=GS F9WH65_TRYCI/451-642     AC F9WH65.1
#=GS Q57U16_TRYB2/29-221      AC Q57U16.1
#=GS Q38CV5_TRYB2/38-224      AC Q38CV5.1
#=GS Q57YD8_TRYB2/239-418     AC Q57YD8.1
#=GS Q38CW2_TRYB2/38-223      AC Q38CW2.1
#=GS F9WNM9_TRYVY/203-382     AC F9WNM9.1
#=GS F9WC09_TRYCI/27-218      AC F9WC09.1
#=GS F9WE92_TRYCI/41-225      AC F9WE92.1
#=GS Q38CV0_TRYB2/38-224      AC Q38CV0.1
#=GS F9WN13_TRYVY/27-221      AC F9WN13.1
#=GS Q57U14_TRYB2/29-220      AC Q57U14.1
#=GS F9WH64_TRYCI/1-137       AC F9WH64.1
#=GS Q57XH8_TRYB2/27-217      AC Q57XH8.1
Q57YD8_TRYB2/27-218                 .......l-EQTVTLCNALKQFRGLK.DAVRDLKYWIT......TESLKISNAKTRS...DEYVTLAE..D...VLWE.N..RNATD.....PVERAKRVASN.V.TEA...AKKAETASIETEFRAENIEEIRSNR...IAALERMLKEVAGH....................NS-NWRVRSAAEKC..KGAAES...VSSDSLNGTLLELFST..LPE....GA.....SEGLEDDTRE....SSGELWKLEF.......VL-.--------------ynvvtwrsvalkges...............
F9WIZ4_TRYCI/34-226                 ........VEAVQSVCELTKIMRGVG.ESTKELQSQAE......AHASEASKAKEES...ESAVGRAE..E...ANEK.S..PEAAD.....ALERAREALSE.A.EEA...SEEAALASKEAEKHAENATSLATGQ...QEDLEKFLREIAED....................IESDEDIKAVARDC..NDTNSS...VTSEGLDSARRNAKKH..FTS....EA.....ANTLENITNA....TVEVFSNLEK.......EVQ.RAKESQDTAEKAR-d.............................
F9WA19_TRYCI/37-229                 ......ll--QTTAACGVAEQLRKLP.AAVDAPLLEAE......RAAERAAKAWNES...DRDAKRAEkaA...AAAG.T..AEAQG.....TAKRARDAAED.A.YTA...SVHAEGEKIKAQQEASKLKDFHEEY...ESPFNKLLEGTAEN....................GK-NSTIKDVAKNC..-GVASD...VTPDSLKATAAALNEQ..YSQ....EF.....MREYGQKATQ....AAESLTELQG.......AAS.EGKKAADDAEEAR-r.............................
F9WV99_TRYVY/153-305                .....lkl---VEFACEVAGQLRGVN.ASAETHASALR......QSVAKTADYLAEA...EKKAAEAA..N...KNES.-..---KE.....VIQKRAAVLAA.V.VSA...HATVLAATANTSEVVDGVKYHAERL...LKGLDEYFVDAQRS....................NA-SEDIKDVAKSCaaAPAAAD...VSSASVDGVKDAAAKA..LG-....--.....----------....----------.......---.--------------dea...........................
F9WVM2_TRYVY/600-805                .......g--QARIICTLMKQLHGVK.RDLIQVMQGVS......SNERNASDASQMA...EDAATSVA..G...----.-..-----.....-TKGDDKRLEE.V.VAA...AIKSREESRRITEDTQRAKNSIDVD...VQGITLYLVFLKSIll...............ditKGDNEYTKDMIDAC..DKSAEN...VTEHSMRAALDEYLRL..KKI....VV.....VRQMRERVGD....VTTDLVKFRQlgeatnlRAQ.HVASYANESMSA--aneikgsadaavaga...............
Q38CV9_TRYB2/38-223                 ......ag--HVRVVCSLAEQLRGLP.DTISSALVTAA......AASSKAFEAKVQA...EEAVELAE..S...RGLN.-..-----.....-VTKAKEAAVR.A.TLA...AEAAATAASNVEIDAANVTSSRLAR...RNP-NTGFEKVAMC....................ENLDKDLREAAAKC..TKKAEN...VTTQSLSETLHRLENL.yTNM....SA.....LESLRVEHVE....IERFFEMLEE.......HVE.EAVRAQRQAEEAAA..............................
A0A1M6NIJ8_9CLOT/35-148             elikdiri---------------QLP.DEVKQAQWIKE......ERNKILVEAQKES...DRIINNAK..D...RIEA.M..ANKDE.....IVKKAKEKAQE.IiYKA...EEKAKTIRIGSIQYADDILKQLETN...TLQIMETLKKNREE....................I-------------..------...----------------..---....--.....----------....----------.......---.--------------kkmn..........................
Q57XH8_TRYB2/239-429                .......l-QQTQALCIAAEQYRALP.IFVSNIEEISK......TMAQKAADAKIRS...DNVVQLAE..E...-ANE.D..GKGKL.....LSQRVRETVNE.I.AEA...AEAAEKAYRALTGHSVYMKSVAAAY...AGSLEKTLLSISQY....................AASQA-TRKAAEAC..RETAEV...VTPKSLEDTKNGLFHS..IPA....QS.....SKRLKKDTAK....LIESLTILHR.......EYK.QLNAAMQYAQAAE-l.............................
F9WEJ8_TRYCI/41-225                 ........VEGVQTMCDVARQLRALE.TASQSAVAAVV......SSARDASEAKERA...EKAVERAK..S...KKRG.-..-----.....-VDTATEAAAR.A.AAA...AQRAETVVSDARKHAADLTAASKDA...IETTDESLRLLATC....................EKADEPIRTAAKKC..TGAAAE...VTSKSLESAFDALAEL..L-P....DG.....ADDIREHGAV....FVKGLKSLED.......DVR.TAGEAKNEAEKAE-g.............................
Q385U1_TRYB2/28-218                 .......l-AQVLTLCQITEQLRGLK.EVVMKIGPRAV......EEALFTLKAKKRS...EVSLRRAE..E...AAER.D..RNAGF.....AAERARLAYDS.V.CEA...VEFAEYAATSIEGRASSLLVIQEYY...VPFLEDVMLRVGTD....................AEAAE-AQEAAMSC..LQTKRS...VSPTSLSEAALELRVR..LGV....RN.....FRALRRDLHR....AAFCLYSLKK.......TAA.KIALARSSVEE---ie............................
G5GGR6_9FIRM/37-165                 .dlltelr--------------HQIP.EEVKQYQKIIS......NQEAIINDAKLQA...DKLIDEAT..R...KAER.L..VDEHE.....IMQKAYDTANKlI.DDA...NTQAQLIIEKATNESNSIKTASIKY...TDDMLKNIQSV---....................--------------..------...----------------..---....--.....----------....----------.......---.--------------vfntmnesqtsfenfmdvlrrny.......
Q57X85_TRYB2/28-230                 .....gde-----AVCELIKQLNGVPwDAVDSMKVHVR......RNATVASQSGAIA...EMEVRKAY..A...AVLR.AasSQSAE.....AIEVVLAAFNK.V.RTA...IVLCNEEIQRVRGLWSQFKDAAVRVvqcAEVANGYLKHLVDD....................AEVSF-RQHVTDKC.nKRERKN...VTADSLNDAMQRALPF..V--....-K.....DPTIRANLTE....TEKLLRELEG.......IVG.AASEARQGAA----qqvpmavaagnea.................
Q57XI0_TRYB2/239-418                .......l-NQTQAVCLMVEQYRGLK.GAVDAFTEQAV......SRSAMVSKVEERS...QADAKRPG..G...----.-..-----.....HMDQVKRAVAE.V.AKA...VSKAQNVFKKVSRYARNLKSIRAHY...LPLMENTLRKIAGN....................AA-DEKAKKAAEVC..GGTAWV...VTPKSLDDMRKKLMDN..FP-....NL.....SERLESDTRV....VSHMLEDLNT.......STQ.--------------litiasiavrrke.................
F9WM12_TRYVY/113-305                ........VEEVKTMCVLLKQLRGVS.PSVEALVTRAN......NSLSTISRYKAKE...DSALEEAR..R...GGSN.E..T----.....-VQKHESRATA.V.GNA...YATAAAAVLSVPDLAANITAASTTI...INEIVESLDDLEKS....................EASEE-VKEAGRPC.aAAPADS..gVTSQSLDGVREAIVKK..AAE....DD.....GAELVEEANSvlghLAAQLRELEA.......AVA.TAAGAEADAKAAS-e.............................
F9WN26_TRYVY/113-305                ........VEEVKTMCVLLKQLRGVS.PSVEALVTRAN......NSLSTISRYKAKE...DSALEEAR..R...GGSN.E..T----.....-VQKHESRATA.V.GNA...YATAAAAVLSVPDLAANITAASTTI...INEIVESLDDLEKS....................EASEE-VKEAGRPC.aAAPADS..gVTSQSLDGVREAIVKK..AAE....DD.....DAELVEEANSvlghLAAQLRELEA.......AVA.TAAGAEADAKAAS-e.............................
F9WMG2_TRYVY/606-799                .......t-EKASVTCSLMRQLIGAR.RDFTRLMHETS......VDEQRAYDASRVA...DDAVARAA..S...----.-..-----.....-TSDDDTELAE.A.AVA...AGLSKGQSERLKGESDQMKASVSKN...LQAIDTSLASLRGVll...............nliRGSGESTQNTVSLC..DESVEN...VTGRSIGAAAKHLAKY..TDL....HN.....IQAACELARE....AAAELVRLHKlwrdidlHAE.RAKMYAEESVDAAA..............................
F9W3K3_TRYCI/27-147                 .......l-DQVNAFCELTKQFRHLP.IAVGQQLDEAI......DEEAKAAKARKDS...QKAVNRAD..A...AAKK.S..EDAKK.....HAQDAKEAAKE.A.FEA...ADGAEVHLQAASELATELNGLVETH...LSRLENILKDAEND....................GE-DEH--------..------...----------------..---....--.....----------....----------.......---.--------------a.............................
F9WP06_TRYVY/468-660                .......g--QARIVCTLMKQLHGVR.RDLIQVMQGVT......SNERNASDASQMA...VDAATSVA..G...----.-..-----.....-TKGDDKRLEE.V.VAA...AIKSREESRRMTEDIQRAKNSIDAD...VQGITLYLVFLKSIll...............ditKGDNEYTKDMIDAC..DKSSEN...VTEHSMRAALDEYLRL..KKF....VV.....VRQIRERVGD....VTTDLVKFRQlgeitnlRAQ.RVASYANESMRAA-n.............................
F9WE93_TRYCI/41-225                 ........VEGVQTMCDVARQLRALE.TASQSAVAAVV......SSAREASEAKERA...EKAVERAK..S...KKRG.-..-----.....-VDTATEAAAR.A.AAA...AQRAETVVSDARKHAADLTAASKDA...IETTDESLRLLATC....................EKADEPIRTAAKKC..TGAAAE...VTSKSLESAFDALAEL..L-P....DG.....ADDIREHGAV....FVKGLKSLED.......DVR.TAGEAKSEAEKAE-g.............................
F9WN27_TRYVY/50-239                 .....lkl---VEFACEVAGQLRGVN.ASAETHASALR......QSVAKTADYLAEA...EKKAAEAA..N...KNES.-..---KE.....VIQKRAAVLAA.V.VSA...HATVLAATANTSEVVDGVKYHAERL...LKGLDEYFVDAQRS....................NA-SEDIKDVAKSCaaAPAAAD...VSSASVDGVKDAAAKA..LGD....EA.....LNFAVAELTA....LAAQLRELEA.......AVA.TAAGAEADAKAAS-e.............................
F9WUH5_TRYVY/604-795                .....krg-----TVCGLIAQLHGLK.LNLTSLKEQTL......QSERAAASARERA...NACKKKAN..A...LVGY.-..--EEL.....PVGKVSGAAEE.A.IEA...GGHGLITARKAGDGADKALASVAEY...LSAVGEVLNSIVC-....................GDVVS--AEISDSC..GVVADE...VTRASLASAVSQYSAL..WNA....TD.....TGRVDERLVY....LSHE------.......---.--------------wetalalhkesvlqseravrlawkaermtr
Q38CV6_TRYB2/38-223                 ......ag--HVRVVCNLAEQLRGLP.DTVSSALVNAA......AASSKAFEAKVQA...EEAVELAE..S...RGLN.-..-----.....-VTKAKEAAVR.A.TLA...AEAAATAASNVEINAANVTSSRLAR...RNP-NTGFEKIAMC....................ENLDEDVREAAVKC..TKKAEN...VTTQSLNEALHRLENL.yTNM....SA.....LESLRVEHVE....IERFFEMLEE.......HVE.EAVSAQRQAEDAAA..............................
Q38CV7_TRYB2/38-224                 .......a-EDVLVLCRVAEQLRGLP.DTVSSALVNAA......TASSKAFEAKVQA...EEAVELAE..S...KGLN.-..-----.....-VTKAKEAAVR.A.TLA...AEAAATAVSYANAHGTKVGSMTEIL...WEA-DEELRELVVC....................KRMDEETIKAAAEC..TGTAEV...VTAQSLSEALEALANLhyGDE....NV.....AETLRRKDVV....FHKELKSLEG.......YVE.EAVHAQKQAEDAAA..............................
F9WQ61_TRYVY/144-278                .....lkl---VEFACEVAGQLRGVN.ASAETHASALR......QSVAKTADYLAEA...EKKAAEAA..N...KNES.-..---KE.....VIQKRAAVLAA.V.VSA...HATVLAATANTSEVVDGVKYHAERL...LKGLDEYFVDAQRS....................NA-SEDIKDVAKSC..AAA---...----------------..---....--.....----------....----------.......---.--------------paaadvss......................
Q38CV8_TRYB2/38-223                 .......l-EGIPALCGVAEQLRGLP.DTISSALVNVA......TASSKAFEAKVQA...EEAVELAE..S...KGLN.-..-----.....-VTKAKEAAVR.A.TLA...AEAAATAASNVEINAANIAAVPWSQ...RRQ-DAGLQKVALC....................DNVDKDVREAAAKC..TKKAEN...VTAESLRAALEALENL.vTDV....KF.....QENLRKEDVE....FHTELKSLED.......HVE.EAVRAQRQAEEAAA..............................
F9W3C7_TRYCI/41-225                 ........VEEVQALCDMARQLRALE.TASQSAVAAVV......SSAREASEAKERA...EKAVERAK..S...KKRG.-..-----.....-VDTATEAAAR.A.AAA...AQRAETVVSDARKHAADLTAASKDA...IETTDESLRLLATC....................EKADEPIRTAAKKC..TGAAAE...VTSKSLESAFDALAEL..VP-....DG.....ADVIRMYGAV....FVVRLKSLED.......DVR.TAGEAKSEAEKAE-g.............................
F9WRL8_TRYVY/59-271                 .......h--DVAAVCSLARQLWGLS.ASIDRLTRRAG......RAAEHAEKARVAA...VAALAKAA..A...VLRT.N..ANAHG.....LAQKAVKVAEE.A.AAA...AVKANASAASA---GARAKASATQP...VDVLASALHNISNSkdieavltlkineampphksNFSKWQVRAIAGNC..SSKVSNrtaVTAESLDHALRAARGT..AGS....PNkawylVKDAETNLSE....TVSAMRELVR.......EVH.EASDARHRA-----a.............................
Q57U18_TRYB2/29-221                 ........VSHVSAACLFSEALHGIP.FGVKALKALAA......ANVSDASKAREGC...QDAVRRAE..D...AFSS.T..PKVEE.....AVGRARAALKE.A.ESA...ENAAKTALSDVEQYAARAPLLAAGK...TAPVDDYLKSVAED....................NSAASTARRIARGC..SLPNRG...VNSWVLKKAVEFGCEF..FTG....DI.....CKILTDGMAD....LRAEYDQLEA.......AVR.RASEARVAARAAE-s.............................
F9WUC1_TRYVY/259-401                .......l-EKVAATCELMRQLHGVS.ADLLPLKEQTL......AHLDRASSAQDRA...REAMRIAS..G...VTGG.-..-----.....----GAALAGE.A.AEA...ASAAEEHADRAEASGNDTAAAADAE...QGNIARHLAALSDTva...............gavADAGEPVPDT-STC..GEAAAN...VTRESMAAAV------..---....--.....----------....----------.......---.--------------alya..........................
F9WA18_TRYCI/37-229                 ......ll--QTTAACGVAEQLRKLP.AAVDAPLLEAE......RAADRAAKAWNES...DRDAKRAEkaA...AAAG.T..AEAQG.....TAKRARDAAED.A.YTA...SVHAEGEKIKAQQEASKLKDFHEEY...ESPFNKLLEGTAEN....................GK-NSTIKDVAKNC..-GVASD...VTPDSLKATAAALNEQ..YSQ....EF.....MREYGQKATQ....AAESLTELQG.......AAS.EGKKAADDAEEAR-r.............................
F9WE90_TRYCI/41-225                 ........VEEVQTMCDVARQLRALE.TASQSAVAAVV......SSAREASEAKERA...EKAVERAK..S...KKRG.-..-----.....-VDAATEAAAR.A.AAA...AQRAETVVSDARKHAADLTAASKDA...IETTDESLRLLATC....................EKADEPIRTAAKKC..TGAAAE...VTSKSLESAFDALAEL..L-P....DG.....ADDIREHGAV....FVKGLKSLED.......DVR.TAGEAKSEAEKAE-g.............................
F9WH65_TRYCI/239-430                .......v-GQAKAFCKLTEQLRGLL.DTVSRHNVTVT......EEVAKTASSKNRS...DEAVKQAE..S...AAGR.N..SDAAP.....HAKRAKEAGEE.V.SAA...ADEAQKAHEDSSRVVQNLRLLAKDK...LSSYDRFLKNVGE-....................RASGKDAQNAAKEC..TDSAVD...VKSEVVEKLNAAFEES..TPG....KP.....FQPVKDLFKK....FSDNLKELEG.......AAD.VASKSRAKAEAAE-k.............................
Q38CW0_TRYB2/38-223                 ........VEEIRASCEVAHQLRGLS.QTVTSAVETSA......AASSKAFEAKVQA...EEAVELAE..S...KGLN.-..-----.....-VTKAKEAAVR.A.TLA...AEAAATAASNVEINAANIAAVPWLE...RRQ-NTGWEVLTKC....................INLDDDIKKMASKC..KSAAEV...VTAESISAALNDLGKT.fINE....KT.....REALRKESVE....FHKELASLEE.......HVE.EAVRAQKRAEDAAA..............................
F9WM65_TRYVY/167-285                ...tadga------------------.-----------......-------------...--------..-...----.-..-----.....-----------.-.---...--AAAAVAANASRLAHGVARAAREL...ATVVAGLMDEVAAS....................SA-PEDTREAARSC..VGPAAN...VSSDSLDEVWNAAAEV..LGG....DA.....LDFLTARVSG....LVGGLRELEA.......AAV.TAEGAEADGKAAS-e.............................
F9WV46_TRYVY/166-284                ...tadga------------------.-----------......-------------...--------..-...----.-..-----.....-----------.-.---...--AAAAVAANASRLAHGVARAAREL...ATVVAGLMDEVAAS....................SA-PEDTREAARSC..VGPAAN...VSSDSLDEVWNAAAEV..LGG....DA.....LDFLTARVSG....LVGGLRELEA.......AAV.TAEGAEADGKAAS-e.............................
Q57XI0_TRYB2/27-218                 .......l-EQTVTLCNALKQFRGLK.DAVRDLKYWIT......TESLKISNAKTRS...DEYVTLAE..D...VLWE.N..RNATD.....PVERAKRVASN.V.TEA...AKKAETASIETEFRAENIEEIRSNR...VAALERMLKEVAGH....................NS-NWRVRSAAEKC..KGAAES...VSSDSLNGTLLELFST..LPE....GA.....SEGLEDDTRE....SSGELWKLEF.......VL-.--------------ynvvtwrsvalkges...............
Q38CV2_TRYB2/38-223                 .......l-EEIRVLCRVAEQLRGLP.ETVSSAVETAA......AASSKAFEAKVQA...EEAVELAE..S...RGLN.-..-----.....-VTKAKEAAVR.A.TLA...AEAAATAASNVEINAANIAAVPWLQ...PIS-DAGLENLSKC....................EHIDKYVQEAAAEC..SKKAEH...VTAQSLSAALEGLENL.fTDV....ST.....REALRKETIE....FHTELKSLEE.......HVE.EAVRAQKRAEDAAA..............................
F9WVN8_TRYVY/75-289                 .......h--DVAAVCSLARQLWGLS.ASIDRLTRRAG......RAAEHAEKARVAA...VAALAKAA..A...VLRT.N..ANAHG.....LAQKAVKVAEE.A.AAA...AVKANASAASA---GARAKASATQP...VDVLASALHNINNSsdvpeiqevrknetmpphksNFSKWQVRAIAGNC..SSKVSNrtaVTAESLDHALRAARGT..AGS....PNkawylVKDAETNLSE....TVSAMRELVR.......EVH.EASDARHRA-----als...........................
F9WQX1_TRYVY/63-253                 .......s-ERISATCDLIGQLSSLK.AQFLSLVEEAL......TYVRSAAGANTKT...DAAEETVA..L...ALNA.-..--SES.....LVREAMAAASK.A.REE...ARHAQYTASGSLEMARKVLEDIAKH...LDWLSAEANSIATG....................MGASA---ATPSEC..VHLNKV...VTMESFTDAVVQYSRL..VGF....FG.....IEHVQRNLLS....VLDNWMWLRRmc...gkAAS.HVNEAVLHAGDA--el............................
F9WKL8_TRYVY/86-292                 ...kesmp------LCDLVGQIWGVN.VSAWRLTKRAQ......RAAELAEECLVKV...KQIVQVAE..A...AQHRsT..PDAKGsvltaALASLKSALDA.V.NTA...AGAASDEARATEKSASDARSHSEEV...KKAFEAVLPNISDIi..................fKAVGNEGNEPNVTC..NNSRTK...VTGDSLSHALLSVNSV..SGApdviKV.....WDAVRSEEARi.tkITVSLRELMV.......HVS.KANGALHSAKDAE-k.............................
Q38CV4_TRYB2/38-225                 .......a-DDVLVLCYLAEQLRGLP.DTISSALVNAA......AASSKAFEAKVQA...EEAVELAE..S...KGLN.-..-----.....-VTKAKEAAVR.A.TLA...AEAAATAASNVEINAANISAFSIDF...LESANLLLFEVRDA....................KDVGEDVRIVAQRC..TGEANF...VTVASLTNALDNVTSLysVYG....KG.....TASLSMESVA....LLEELKMLED.......GLK.KSQVAVSVAADAA-d.............................
F9WC09_TRYCI/239-430                .......v-GQAKAFCKLTEQLRGLL.DTVSRHNVTVT......EEVAKTASSKNRS...DEAVKQAE..S...AAGR.N..SDAAP.....HAKKAKEAGEE.V.SAA...ADEAQKAHEDSSRVVQDLRLLAKDK...LSSYDRFLKNVGE-....................RASGKDAQNAAKEC..TDSAVD...VKSEVVEKLNAAFEES..TPG....KP.....FQPVKDLFKK....FSDNLKELEG.......AAD.VASKSRAKAEAAE-k.............................
F9WC09_TRYCI/451-642                .......l-KQVNAFCGLAEQFRGLL.NSVKKLEGQAT......HCATVAAAVKARS...TETVKRVV..A...AAGK.N..ASAKE.....LAERAQAVEAE.V.TAA...ADKAQEAYAGVSGFVGNLTASRDEH...LLVLEDVITGAKTS....................ASCSCGIR-AAKAC..TAAAED...VTAESLKEAKDTFRQD..IPG....DH.....YKELSDGAEN....VSGRLEELRS.......TAQ.RVSASRAAAQAAEE..............................
F9WRF2_TRYVY/70-259                 .....lkl---VEFACEVAGQLRGVN.ASAETHASALR......QSVAKTADYLAEA...EKKAAEAA..N...KNES.-..---KE.....VIQKRAAVLAA.V.VSA...HATVLAATANTSEVVDGVKYHAERL...LKGLDEYFVDAQRS....................NA-SEDIKDVAKSCaaAPAAAD...VSSASVDGVKDAAAKA..LGD....EA.....LNFAVAELTA....LAAQLRELEA.......AVA.TAAGAEADAKAAS-e.............................
Q57U10_TRYB2/29-221                 ........VSHVSAACLFSEALHGIP.FGVKALKASAA......ANVSDASKAREGC...QDAVRRAE..D...AFSS.T..PKVEE.....AVGRARAALKE.A.ESA...ENAAKTALSDVEQYAARAPLLAAGK...TAPIDDYLKSVAED....................NSAASTARRIARGC..SLPNRG...VNSWVLTQAVESACAI..FMG....EI.....CRIARTRMVD....LRAEYDQLEA.......AVR.RASEARVAARAAE-s.............................
Q38CW1_TRYB2/38-223                 .......a-EDVLVLCRVAEQLRGLP.DTVSSALVNAA......TASSKAFEAKVQA...EEAVELAE..S...KGLN.-..-----.....-VTKAKEAAVR.A.TLA...AEAAATAASNVEINAANIAAVPWLE...RRQ-NVGWQKLAKC....................IDLDMDMREAARVC..RRAADN...VTAQSLTAALKDLEKV.yTDV....ST.....REALRKETVE....FHKELASLEE.......HVE.EAVRAQKRAEDAAA..............................
F9WC08_TRYCI/50-241                 .......l-KQVNAFCGLAEQFRGLL.NSVKKLEGQAT......HCATVAAAVKARS...TETVKRVV..A...AAGK.N..ASAKE.....LAERAQAVEAE.V.TAA...ADKAQEAYAVVSGFVGNLTASRDEH...LLVLEDVITGAKTS....................ASCSCGIR-AAKAC..TAAAED...VTAESLKEAKDTFRQD..IPG....DH.....YKELSDGAEN....VSGRLEELRS.......TAQ.RVSASRAAAQAAEE..............................
Q57U12_TRYB2/29-220                 ........VSHVSAACLMSEALHGVP.NSVKVFKTSAA......ANVLDASKAREGC...QDAVRRAE..D...AFSS.T..PKVEE.....AVGRARAALKE.A.ESA...ENAAKTALSDVEQYAANASALANNN...VALVDDYLKSVAED....................NSAASTARRIARDC..NAPL-E...VSSWVLTQAVESGCAV..FMT....VI.....CNTARTRMAD....LRAEYDQLEA.......AVR.RASEARVAARAAE-s.............................
Q38CU9_TRYB2/38-223                 ......av--YVTALCRVAEQLRGLG.GTISSSLLTVT......SASSKAFKAKVQA...EKAVKLAE..S...RGLN.-..-----.....-VTKAKEAAVR.A.TLA...AEAAATAVSYCITHSTKVGSIAEML...WEV-DEELHVFSLC....................GNKDRDVQDTALKC..TDTAEG...VTAQSLSEALEGLAKL.vFDD....NV.....ARKLRQEDTV....FQREFMWLQQ.......HME.EAVRAQKQAEDAAA..............................
F9WE91_TRYCI/41-225                 ........VEEVQTMCDVARQLRALE.TASQSAVGAVV......SSARDASEAKERA...EKAVERAK..S...KKRG.-..-----.....-VDAATEAAAR.A.AAA...AQRAETVVSDARKHAADLTAASKDA...IETTDESLRLLATC....................EKADEPIRTAAKKC..TGAAAE...VTSKSLESAFDALAEL..L-P....DG.....ADDIREHGAV....FVKGLKSLED.......DVR.TAGEAKSEAEKAE-g.............................
F9WQR4_TRYVY/166-284                ...tadga------------------.-----------......-------------...--------..-...----.-..-----.....-----------.-.---...--AAAAVAANASRLAHGVARAAREL...ATVVAGLMDEVAAS....................SA-PEDTREAARSC..VGPAAN...VSSDSLDEVWNAAAEV..LGG....DA.....LDFLTARVSG....LVGGLRELEA.......AAV.TAEGAEADGKAAS-e.............................
F9WH65_TRYCI/27-230                 .......l-DQVNAFCELTKQFRHLP.IAVGQQLDEAI......DEEAKAAKARKDS...QKAVNRAD..A...AAKK.S..EDAKK.....HAQDAKEAAKE.A.FEA...ADGAEVHLQAASELATELNGLVETH...LSRLENILKDAETD....................GE-DEHAREAAKEC..TGNATN...VTSGTLLESKEKLEKA..AGK....ED.....YEELRYDTER....AGSLLDDLKG.......AQL.EVSSLQIKATNAEErateaaakakaa..................
F9WV98_TRYVY/82-271                 .....lkl---VEFACEVAGQLRGVN.ASAETHASALR......QSVAKTADYLAEA...EKKAAEAA..N...KNES.-..---KE.....VIQKRAAVLAA.V.VSA...HATVLAATANTSEVVDGVKYHAERL...LKGLDEYFVDAQRS....................NA-SEDIKDVAKSCaaAPAAAD...VSSASVDGVKDAAAKA..LGD....EA.....LNFAVAELTA....LAAQLRELEA.......AVA.TAAGAEADAKAAS-e.............................
F9WTA4_TRYVY/603-782                ......ir---VDAVCSLMRQLNGAK.KRFARLIQETL......KDERRAADARRVA...ADNGDSAP..L...----.-..-----.....----AKKAGER.S.AEE...LDLVRKGGKRIREGAERDVQSIDLH...LVFLRNVLLNLNSG....................RANGS--RNLTAFC..DEAQDN...VTDESIQAAVVRLVRS..RGI....AD.....AATAQRRVRD....VAADLTTLHA.......LSR.DAGSHSERAAA---yaeesia.......................
F9WDT3_TRYCI/37-229                 ......ll--QTTAACGVAEQLRKLP.AAVDAPLLEAE......RAADRAAKAWNES...DRDAKRAEkaA...AAAG.T..AEAQG.....TAKRARDAAED.A.YTA...SVHAEGEKIKAQQEASKLKDFHEEY...ESPFNKLLESAAED....................GK-NSTIKDVAKNC..-GVASD...VTPDSLKATAAALNEQ..YSQ....EF.....MREYGQKATQ....AAESLTELQG.......AAS.EGKKAADDAEEAR-r.............................
Q38CV3_TRYB2/38-223                 ........VDEIPVLCRVAEQLRGLP.DTISSAVETAA......AASSKAFEAKVQA...EEAVELAE..S...KGLN.-..-----.....-VTKAKEAAVR.A.TLA...AEAAATAASNVEINAANIAAVPWSQ...RRQ-DVGLQELALC....................DNVDKDVREAAAKC..TKKADN...VTAQSLSAALEALENL.yTDV....NT.....RETLRREDVE....FHTELKSLEE.......HVE.EAVRAQKQAEDAAA..............................
Q38CV1_TRYB2/38-223                 .......l-KHIEVLCNLAEQLRGLP.DTVSSAVISVT......EASIKASKAKVQA...EEAVELAE..S...KGLN.-..-----.....-VTKAKEAAVR.A.TLA...AEAAATAASNVEINAANIAELPWSQ...RRR-DAGLQNIEHC....................KNLDKDVREAAVKC..TKKAEN...VTADSLRAALEGLETL.fSDV....YI.....LVTLRKEKVE....MQEEMQSLEQ.......NAA.TVLRVLQKAEDAAA..............................
Q57Z47_TRYB2/32-225                 .......l-EQTKALCEVAKQLRKLP.LLTEERRFEAV......GALEESKKAAKEG...KKAAKRAE..A..gAVGG.T..SEQQQ.....AAKRAREAATV.A.YEA...SVRAEAAAMEVKRFARALDSFESEY...ESVFSGLLRGAAEH....................GG-NETIKQLAKEC.aTAVADD...VTPEALTRAAHNLRGL..YMQ....DF.....AEEYLQEANE....AANKLEELQK.......ATA.ETVRAADAADDAK-s.............................
F9WUB1_TRYVY/36-256                 .......r-EEVDNVCDLVRTLQGIS.ISVGIDLRSVTsgdcawSHERTISRAKETTntiTRHLKRVD..G...ALGH.-..-----.....-LSARGEALAR.V.AKAkasVEAARAAVSALEDRIQNATRGVVAV...QNLRAELLNKSRKAtddafqahptvrahidhmkhNASQQEVREAAEKC.sQWSKYD...VTAKSLNETVRKAKSY..MEN....AA.....VRDLVHRAVT....SMTDFADLVK.......HFKnKMSLLCDAAENAT-ag............................
F9WK97_TRYVY/67-256                 .....lkl---VEFACEVAGQLRGVN.ASAETHASALR......QSVAKTADYLAEA...EKKAAEAA..N...KNES.-..---KE.....VIQKRAAVLAA.V.VSA...HATVLAATANTSEIVDGVKYHAERL...LKGLDEYFVDAQR-....................SNASEDIKDVAKSCaaAPAAAD...VSSASVDGVKDAAAKA..LGD....EA.....LNFAVAELTA....LAAQLRELEA.......AVA.TAAGAEADAKAAS-e.............................
F9WH65_TRYCI/451-642                .......l-KQVNAFCGLAEQFRGLL.NSVKKLEGQAT......HCATVAAAVKARS...TETVKRVV..A...AAGK.N..ASAKE.....LAERAQAVEAE.V.TAA...ADKAQEAYAGVSGFVGNLTASRDEH...LLVLEDVITGAKTS....................ASCSCGIR-AAKAC..TAAAED...VTAESLKEAKDTFRQD..IPG....DH.....YKELSDGAEN....VCGRLEELRS.......TAQ.RVSASRAAAQAAEE..............................
Q57U16_TRYB2/29-221                 ........VSHVSAACLFSEALHGIP.FGVKALKALAA......ANVSDASKAREGC...QDAVRRAE..D...ASWN.N..PKAEE.....AVGRARAALKE.A.ESA...ENAAKTALSDVEQYAARAPLLAAGK...TAPIDDYLKSVAED....................NSAASTARRIARGC..SLPNRG...VNSWVLTQAVESACAI..FMG....EI.....CRIARTRMVD....LRAEYDQLEA.......AVR.RAGEARVAARAAE-s.............................
Q38CV5_TRYB2/38-224                 .......a-EDVLVLCHVAEQLRGLP.DTVSSALVTAA......AASSKAFEAKVQA...EEAVELAE..S...RGLN.-..-----.....-VTKAKEAAVR.A.TLA...AEAAATAVSYANAHGTKVGSMTEIL...WEA-DEELRELVVC....................KRMDEETIKAAAEC..TGTAEV...VTAQSLSEALEALANLhyGDE....NV.....AETLRRKDVV....FHKELKSLEG.......YVE.EAVHAQKQAEDAAA..............................
Q57YD8_TRYB2/239-418                .......l-NQTQAVCLMVEQYRGLK.GAVDAFTEQAV......SRSAMVSKVEERS...QADAKRPG..G...----.-..-----.....HMDQVKRAVAE.V.AKA...VSKAQNVFKKVSRYARNLKSIRAHY...LPLMENTLRKIAGN....................AA-DEKAKKAAEVC..GETAWV...VTPKSLDDMRKKLMDN..FP-....NL.....SERLESDTRV....VSHMLEDLNT.......STQ.--------------litiasiavrrke.................
Q38CW2_TRYB2/38-223                 ......ad--VVRILCHVAGQLRGLS.QTVSSAVETAA......AASSKAFEAKVQA...EEAVELAE..S...RGLN.-..-----.....-VTKAKEAAVR.A.THA...AEAAALAASNLAFAAANIAAVPWSQ...PIS-DSMLHKLALC....................DHVDEYVREAAKKC..TKKAKN...VTAQSLNEVLKAFEKL.fSEV....NA.....LQSLRHNIAE....FHKDLKSLED.......HVE.DIVRAQKNAEDAAA..............................
F9WNM9_TRYVY/203-382                ......is---VDAVCSLMRQLNGAK.KNIMRLVQETL......EDERRATDARRVA...ADHGDSAP..L...----.-..-----.....-----------.A.KKA...SERSAEELELVRKGARRIREGVERD...VQSIDLHLVSLRNVlln.............lnsgRANG--SRNLTAFC..DEAQDR...VMGESIRVSVVRLVRS..RGI....AD.....AATAHRRVRD....VAADLTTLHG.......LSR.DAGSHSERAAA---yaeesia.......................
F9WC09_TRYCI/27-218                 .......l-DHVNAFCELTKQFRHLP.IAVGQQLDEAI......DEEAKAAKARKDS...QKAVNRAD..A...AAKK.S..EDAKK.....HAQDAKEAAKE.A.FEA...ADGAEVHLQAASELATELNGLVETH...LSRLEEYLKDAETK....................GE-DERAQEAAKEC..TGNATN...VTSGTLLESKEKLEKA..AGK....ED.....YEELRYDTER....AGSLLDDLKG.......AQL.EVSSLQIKATNAEE..............................
F9WE92_TRYCI/41-225                 ........VEGVQTMCDVARQLRALE.TASQSAVAAVV......SSAREASEAKERA...EKAVERAK..S...KKRG.-..-----.....-VDTATEAAAR.A.AAA...AQRAETVASDARKHAADLTAASKDA...IETTDESLRLLATC....................EKADEPIRTAAKKC..TGAAAE...VTSKSLESAFDALAEL..L-P....DG.....ADDIREHGAV....FVKGLKSLED.......DVR.TAGEAKSEAEKAE-g.............................
Q38CV0_TRYB2/38-224                 .......r-DDIQALCRAAEQFRGLS.QTVTSAVETSA......AASSKAFEAKVQA...EEAVELAE..S...RGLN.-..-----.....-VTKAKEAAVR.A.TLA...AEAAATAASNVEIDAANIAAVPWSQ...PSS-DAGLQKLALC....................ENIDKSLRQLASKC..SKRAEN...VTAQSLSEALEGLRKLhyNDV....YV.....KEILEREDVE....FHKEFMWLQH.......HLR.EAVRAQKQAEDAAA..............................
F9WN13_TRYVY/27-221                 ........VEGVHALCKVLQQLKGVP.SYIDNVEKTVR......KDVESCEEAVAKS...EASFQVVE..SiiaELEN.D..TGLEE.....LFKSIEDERLK.A.SGA...ADDAVLGLRQFQRSENEVVHVITLY...KNYVMKKIEGKKEY....................AN-DPKVREAAKDC..TETDYS...VTVASLGEALKEFIDL..SPS....DY.....DTAIEKDVNL....TISHIEFLES.......IAK.RISEDVNEAVTAAA..............................
Q57U14_TRYB2/29-220                 ........VSHVSAACLMSEALHGVP.NSVKVFKTSAA......ANVSDASKAREGC...QDAVRRAE..D...AFSS.T..PKVEE.....AVGRARAALKE.A.ESA...ENAAKTALSDVEQYAANASALANNN...VALVDDYLKSVAED....................NSAASTARRIARDC..NAPL-E...VSSWVLTQAVESGCAV..FMT....VI.....CNTARARMAD....LRAEYDQLEA.......AVR.RASEARVAARAAE-s.............................
F9WH64_TRYCI/1-137                  .......n------------------.-----------......-------------...--------..-...----.-..ASAKE.....LAERAQAVEAE.V.TAA...ADKAQEAYAGVSGFVGNLTASRDEH...LLVLEDVITGAKTS....................ASCSCGIR-AAKAC..TAAAED...VTAESLKEAKDTFRQD..IPG....DH.....YKELSDGAEN....VSGRLEELRS.......TAQ.RVSASRAAAQAAEE..............................
Q57XH8_TRYB2/27-217                 .......l-EQTVTLCNALKQFRGLK.DAVRDLKYWIT......TESLKISNAKTRS...DEQLRRVK..E...PAQA.T..TKAKA.....LEKRARVLAAN.V.TEA...VKKAEIVILESDVDAGVLGTISSAY...VPSLEGALKKLGNE....................GGTVE-VKGVAKSC..NKTTKN...VTVESLIHALDDMLQY..FPA....KS.....IKRLKEATRD....ASNKLHKLEG.......AAQ.SLVEIKINAEY---te............................
#=GC seq_cons                       .......h.tplpshCplscQLRGLs.sslpshhtpss......ssspcAucA+tpu...-cslcpAc..u...ttts...............sp+AccAssc.s.stA...uptApsusssspphAsslsshspph...hpsh-phLcplsps....................ps.scph+csAcpC..sssAps...VTupSLppuhcshtph..hs.....ps.....hcplcpcssp....httpLcpLcs.......tsp.pustAptpAcsAt...............................
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