GenomeNet

Database: Pfam
Entry: GCSF
LinkDB: GCSF
Original site: GCSF 
#=GF ID   GCSF
#=GF AC   PF16647.6
#=GF DE   Granulocyte colony-stimulating factor
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   PF00489
#=GF GA   30.40 30.40;
#=GF TC   31.10 30.70;
#=GF NC   30.00 29.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   10537111
#=GF RT   Atomic structure of the GCSF-receptor complex showing a new
#=GF RT   cytokine-receptor recognition scheme.
#=GF RA   Aritomi M, Kunishima N, Okamoto T, Kuroki R, Ota Y, Morikawa K;
#=GF RL   Nature. 1999;401:713-717.
#=GF RN   [2]
#=GF RM   16492764
#=GF RT   Homodimeric cross-over structure of the human granulocyte
#=GF RT   colony-stimulating factor (GCSF) receptor signaling complex.
#=GF RA   Tamada T, Honjo E, Maeda Y, Okamoto T, Ishibashi M, Tokunaga M,
#=GF RA   Kuroki R;
#=GF RL   Proc Natl Acad Sci U S A. 2006;103:3135-3140.
#=GF DR   INTERPRO; IPR040117;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   GCSF is a family of higher eukaryotic granulocyte
#=GF CC   colony-stimulating factor proteins. Granulocyte
#=GF CC   colony-stimulating factors are cytokines that are involved in
#=GF CC   haematopoeisis.  They control the production, differentiation
#=GF CC   and function of white blood cell granulocytes. GCSF binds to the
#=GF CC   extracellular Ig-like and CRH domain of its receptor GCSFR,
#=GF CC   thereby triggering the receptor to homodimerise [1].
#=GF CC   Homodimerisation result in activation of Janus tyrosine
#=GF CC   kinase-signal transducers and other activators of transcription
#=GF CC   (JAK-STAT)-type signalling cascades [2].
#=GF SQ   137
#=GS A0A2Y9DP86_TRIMA/42-190   AC A0A2Y9DP86.1
#=GS A0A2K6B742_MACNE/47-195   AC A0A2K6B742.1
#=GS H0X3R6_OTOGA/42-190       AC H0X3R6.1
#=GS G1KVP0_ANOCA/48-195       AC G1KVP0.2
#=GS M7BE55_CHEMY/61-218       AC M7BE55.1
#=GS A0A2K6B755_MACNE/51-202   AC A0A2K6B755.1
#=GS F7GL96_CALJA/65-166       AC F7GL96.2
#=GS H2R024_PANTR/51-199       AC H2R024.2
#=GS A0A2K5RS68_CEBCA/51-202   AC A0A2K5RS68.1
#=GS A0A384BZE1_URSMA/42-190   AC A0A384BZE1.1
#=GS A0A1A6HM10_NEOLE/80-228   AC A0A1A6HM10.1
#=GS CSF3_SHEEP/21-169         AC Q28746.1
#=GS H0YVL5_TAEGU/1-137        AC H0YVL5.1
#=GS F7H1Q3_MACMU/47-195       AC F7H1Q3.2
#=GS A0A2K5CMX6_AOTNA/51-202   AC A0A2K5CMX6.1
#=GS G3QQS4_GORGO/51-202       AC G3QQS4.1
#=GS Q8N4W3_HUMAN/47-195       AC Q8N4W3.1
#=GS A0A1S3WLA0_ERIEU/42-190   AC A0A1S3WLA0.1
#=GS A0A3Q3LQQ8_9TELE/79-221   AC A0A3Q3LQQ8.1
#=GS A0A1U7UFL0_TARSY/51-205   AC A0A1U7UFL0.1
#=GS A0A452EPD7_CAPHI/43-191   AC A0A452EPD7.1
#=GS A0A452H1C5_9SAUR/48-199   AC A0A452H1C5.1
#=GS U3JCF4_FICAL/45-195       AC U3JCF4.1
#=GS A0A2K6P8H6_RHIRO/60-159   AC A0A2K6P8H6.1
#=GS G1SXQ9_RABIT/51-199       AC G1SXQ9.1
#=GS A0A2K5ZFP1_MANLE/51-202   AC A0A2K5ZFP1.1
#=GS A0A1S3GX54_DIPOR/53-204   AC A0A1S3GX54.1
#=GS A0A1L8ERX3_XENLA/65-210   AC A0A1L8ERX3.1
#=GS CSF3_HUMAN/51-202         AC P09919.1
#=GS CSF3_HUMAN/51-202         DR PDB; 1CD9 A; 22-170;
#=GS CSF3_HUMAN/51-202         DR PDB; 1PGR G; 22-170;
#=GS CSF3_HUMAN/51-202         DR PDB; 1PGR A; 22-170;
#=GS CSF3_HUMAN/51-202         DR PDB; 1CD9 C; 22-170;
#=GS CSF3_HUMAN/51-202         DR PDB; 5GW9 B; 22-170;
#=GS CSF3_HUMAN/51-202         DR PDB; 1PGR C; 22-170;
#=GS CSF3_HUMAN/51-202         DR PDB; 2D9Q A; 21-169;
#=GS CSF3_HUMAN/51-202         DR PDB; 1RHG A; 21-169;
#=GS CSF3_HUMAN/51-202         DR PDB; 1GNC A; 22-170;
#=GS CSF3_HUMAN/51-202         DR PDB; 5GW9 D; 22-170;
#=GS CSF3_HUMAN/51-202         DR PDB; 5GW9 C; 22-170;
#=GS CSF3_HUMAN/51-202         DR PDB; 1RHG C; 21-169;
#=GS CSF3_HUMAN/51-202         DR PDB; 5ZO6 X; 15-163;
#=GS CSF3_HUMAN/51-202         DR PDB; 5GW9 A; 22-170;
#=GS CSF3_HUMAN/51-202         DR PDB; 1RHG B; 21-169;
#=GS CSF3_HUMAN/51-202         DR PDB; 1PGR E; 22-170;
#=GS CSF3_FELCA/41-189         AC O02708.1
#=GS A0A2K5TUV9_MACFA/47-195   AC A0A2K5TUV9.1
#=GS A0A226NQK2_COLVI/1-136    AC A0A226NQK2.1
#=GS A0A2I3N0F9_PAPAN/65-166   AC A0A2I3N0F9.1
#=GS M3YU08_MUSPF/51-199       AC M3YU08.1
#=GS A0A2U3VJM2_ODORO/42-190   AC A0A2U3VJM2.1
#=GS A0A2K5MBQ8_CERAT/65-166   AC A0A2K5MBQ8.1
#=GS G3WLV1_SARHA/68-216       AC G3WLV1.1
#=GS I3M5J4_ICTTR/53-205       AC I3M5J4.2
#=GS J3KTH8_HUMAN/60-159       AC J3KTH8.1
#=GS A0A2K6P8H9_RHIRO/51-199   AC A0A2K6P8H9.1
#=GS A0A452RK93_URSAM/42-190   AC A0A452RK93.1
#=GS A0A3L8RZ37_CHLGU/42-192   AC A0A3L8RZ37.1
#=GS L5JTJ0_PTEAL/42-190       AC L5JTJ0.1
#=GS A0A2K5TUW1_MACFA/65-166   AC A0A2K5TUW1.1
#=GS A0A2K6P8I2_RHIRO/47-195   AC A0A2K6P8I2.1
#=GS A0A2K5RS65_CEBCA/47-195   AC A0A2K5RS65.1
#=GS A0A3P8Y1V0_ESOLU/33-190   AC A0A3P8Y1V0.1
#=GS A0A455B220_PHYMC/42-190   AC A0A455B220.1
#=GS A0A151P5I2_ALLMI/1-149    AC A0A151P5I2.1
#=GS A0A383ZRC8_BALAS/42-190   AC A0A383ZRC8.1
#=GS A0A1S3GWV7_DIPOR/53-201   AC A0A1S3GWV7.1
#=GS A0A1U7QNT5_MESAU/84-232   AC A0A1U7QNT5.2
#=GS A0A2K5JMV2_COLAP/51-202   AC A0A2K5JMV2.1
#=GS A0A340XVI9_LIPVE/42-190   AC A0A340XVI9.1
#=GS A0A1U7UBL4_TARSY/67-169   AC A0A1U7UBL4.1
#=GS A0A1L8EKK4_XENLA/64-206   AC A0A1L8EKK4.1
#=GS A0A087QGK3_APTFO/1-137    AC A0A087QGK3.1
#=GS W5PSS6_SHEEP/42-195       AC W5PSS6.1
#=GS H9KVK4_CALJA/51-202       AC H9KVK4.1
#=GS CSF3_BOVIN/42-190         AC P35833.2
#=GS CSF3_BOVIN/42-190         DR PDB; 1BGC A; 22-170;
#=GS A0A2K5ZFL0_MANLE/65-166   AC A0A2K5ZFL0.1
#=GS L9JXF3_TUPCH/38-185       AC L9JXF3.1
#=GS A0A2I2UX56_FELCA/51-199   AC A0A2I2UX56.1
#=GS G1NZX6_MYOLU/51-199       AC G1NZX6.1
#=GS A0A2I3T1Y4_PANTR/64-166   AC A0A2I3T1Y4.1
#=GS A0A3Q7S1A7_VULVU/42-190   AC A0A3Q7S1A7.1
#=GS A0A0Q3X8P5_AMAAE/15-73    AC A0A0Q3X8P5.1
#=GS H0VSM3_CAVPO/56-204       AC H0VSM3.2
#=GS A0A1U7U5G1_TARSY/51-199   AC A0A1U7U5G1.1
#=GS A0A493T676_ANAPP/48-198   AC A0A493T676.1
#=GS A0A3M0JRR3_HIRRU/538-688  AC A0A3M0JRR3.1
#=GS A0A4D9ETT6_9SAUR/27-178   AC A0A4D9ETT6.1
#=GS A0A2R8ZJQ3_PANPA/51-199   AC A0A2R8ZJQ3.1
#=GS A0A3Q7XQE4_URSAR/42-190   AC A0A3Q7XQE4.1
#=GS G3INY3_CRIGR/57-205       AC G3INY3.1
#=GS A0A2K5RS88_CEBCA/65-166   AC A0A2K5RS88.1
#=GS G3PPJ2_GASAC/44-197       AC G3PPJ2.1
#=GS CSF3_PIG/42-190           AC O02837.2
#=GS A0A226N813_CALSU/46-196   AC A0A226N813.1
#=GS A0A2K5TUV5_MACFA/51-202   AC A0A2K5TUV5.1
#=GS A0A2U3Z1Q3_LEPWE/42-190   AC A0A2U3Z1Q3.1
#=GS J3QRX2_HUMAN/64-155       AC J3QRX2.1
#=GS A0A096P5E3_PAPAN/51-202   AC A0A096P5E3.2
#=GS MGF_CHICK/46-196          AC P13854.1
#=GS A0A452EPF0_CAPHI/73-221   AC A0A452EPF0.1
#=GS A0A2K6T175_SAIBB/65-166   AC A0A2K6T175.1
#=GS A0A1D5R4Y8_MACMU/65-166   AC A0A1D5R4Y8.1
#=GS A0A452EN91_CAPHI/55-203   AC A0A452EN91.1
#=GS A0A2K6KWG7_RHIBE/51-199   AC A0A2K6KWG7.1
#=GS A0A3Q0GKF4_ALLSI/77-230   AC A0A3Q0GKF4.1
#=GS A0A091V0J9_NIPNI/30-154   AC A0A091V0J9.1
#=GS H3B4W7_LATCH/58-207       AC H3B4W7.1
#=GS A0A2K5JMV7_COLAP/65-166   AC A0A2K5JMV7.1
#=GS F7CRM4_MONDO/51-206       AC F7CRM4.1
#=GS A0A2R8ZKP4_PANPA/64-166   AC A0A2R8ZKP4.1
#=GS A0A1U7UNR8_TARSY/60-163   AC A0A1U7UNR8.1
#=GS Q8MKE0_HORSE/1-122        AC Q8MKE0.1
#=GS A0A1V4JQZ4_PATFA/47-197   AC A0A1V4JQZ4.1
#=GS G1QLG1_NOMLE/65-166       AC G1QLG1.2
#=GS CSF3_MOUSE/57-205         AC P09920.1
#=GS A0A2Y9K8B4_ENHLU/42-190   AC A0A2Y9K8B4.1
#=GS A0A3B3QFB9_9TELE/47-200   AC A0A3B3QFB9.1
#=GS A0A2Y9LVQ5_DELLE/42-190   AC A0A2Y9LVQ5.1
#=GS F6RBW9_ORNAN/1-135        AC F6RBW9.1
#=GS A0A091DWP2_FUKDA/333-481  AC A0A091DWP2.1
#=GS A0A3Q3VKR8_MOLML/51-197   AC A0A3Q3VKR8.1
#=GS F7H1Q6_MACMU/51-202       AC F7H1Q6.2
#=GS A0A2K6KWH4_RHIBE/65-166   AC A0A2K6KWH4.1
#=GS A0A2K6B759_MACNE/65-166   AC A0A2K6B759.1
#=GS A0A452EN95_CAPHI/27-175   AC A0A452EN95.1
#=GS H9H288_MELGA/51-182       AC H9H288.1
#=GS A0A2K6GYC7_PROCO/46-194   AC A0A2K6GYC7.1
#=GS A0A1S3GWK7_DIPOR/66-165   AC A0A1S3GWK7.1
#=GS K7FXS9_PELSI/136-195      AC K7FXS9.1
#=GS G5BRY2_HETGA/52-200       AC G5BRY2.1
#=GS A0A2I2Y806_GORGO/64-166   AC A0A2I2Y806.1
#=GS H2NU88_PONAB/51-202       AC H2NU88.1
#=GS A0A337SB92_FELCA/60-159   AC A0A337SB92.1
#=GS A0A2I3GCQ2_NOMLE/51-202   AC A0A2I3GCQ2.1
#=GS F6X4E9_XENTR/41-178       AC F6X4E9.1
#=GS A0A1S3GZ92_DIPOR/66-168   AC A0A1S3GZ92.1
#=GS A0A0D9S358_CHLSB/51-202   AC A0A0D9S358.1
#=GS CSF3_CANLF/22-170         AC P35834.1
#=GS CSF3_CANLF/22-170         DR PDB; 1BGE B; 22-170;
#=GS CSF3_CANLF/22-170         DR PDB; 1BGD A; 22-170;
#=GS CSF3_CANLF/22-170         DR PDB; 1BGE A; 22-170;
#=GS A0A402E872_9SAUR/39-138   AC A0A402E872.1
#=GS G3T268_LOXAF/51-199       AC G3T268.1
#=GS K7FXS9_PELSI/42-116       AC K7FXS9.1
#=GS F1PZP1_CANLF/51-199       AC F1PZP1.2
#=GS F6T8Z5_HORSE/42-190       AC F6T8Z5.2
#=GS G1LTB3_AILME/51-199       AC G1LTB3.1
#=GS P97712_RAT/48-196         AC P97712.1
#=GS A0A3P8ZXD8_ESOLU/45-202   AC A0A3P8ZXD8.1
#=GS A0A091FKF3_9AVES/19-164   AC A0A091FKF3.1
#=GS A0A2K5MBQ3_CERAT/51-199   AC A0A2K5MBQ3.1
#=GS A0A2K5CMX9_AOTNA/65-166   AC A0A2K5CMX9.1
#=GS A0A2K6T182_SAIBB/51-202   AC A0A2K6T182.1
#=GS A0A3Q2CHK1_CYPVA/36-183   AC A0A3Q2CHK1.1
#=GS W5N5E3_LEPOC/49-203       AC W5N5E3.1
A0A2Y9DP86_TRIMA/42-190              .........................................VRKIRADGAVLQER.......LC..ATHKLCH.PE....ELVLLGHS..L..GIAQAP.LSSCSSQTLEV..VDCLSQLHGGLFLYQGLLQALAGISPEV..T..P.T..LDLLQ.....L.DVKDFAINI..RQ..QMEDLGV.AP..TG.....QP..T...Q..G..P......ML.T.FTSA....FQRQAGGVLVASNLQSFLEQAYRVLR..................................................
A0A2K6B742_MACNE/47-195              .........................................VRKIQGDGAALQEK.......LC..ATYKLCH.PE....ELVLLRHS..L..GIPWAP.LSSCSSQAPQL..TGCLSQLHSSLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DIADFATTI..WQ..QMEDLGM.AP..AL.....QP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASHLQRFLELAYRVLR..................................................
H0X3R6_OTOGA/42-190                  .........................................VRKIQNEGAALQEN.......LC..ATYKLCH.PE....ELVLLGHS..L..GIPRTT.LNGCPSQDLQL..TSCLSQLHRGLFLYQGLLQALAGISPEL..A..P.T..LDMLQ.....L.DVADLATTI..WQ..QMEDLGV.AP..AL.....QP..T...Q..G..A......MP.T.FTSA....FQRRAGGILVTSHLQSFLELAYRVLR..................................................
G1KVP0_ANOCA/48-195                  .......................................va--RMKSEISDLKES.......MR..TDFSLGT.DD....QFLFMQDF..L..GIEQAD.HSHCQKATCDL..GNCFKQLRAGLHTYYGYLSHIKQILPNY..T..N.R..VSSLQ.....L.DTSNLSTNI..QL..QFEESSL.PV..VT.....YP..Q...A..E..N......QP.N.FLQ-....EQREIGSYLVLRKFMLFMDVITRAL-n.................................................
M7BE55_CHEMY/61-218                  .........................................IRKIKGDVAQVQEL.......VC..TTLQLCN.EE....ELMLVKQK..L..GISQAP.LNQCHSKTFQV..DACFSQIRDGLQIYHGHLAILLQLLPAH..S..S.L..VDGLRpggspLtSSSRYTAPL..AP..PMEDLGL.NT..VT.....YP..KaegH..G..T......LP.S.LSSD....FDKQASGFIIPANFKRFLEAAFRALR..................................................
A0A2K6B755_MACNE/51-202              .........................................VRKIQGDGAALQEKl....vsEC..ATYKLCH.PE....ELVLLRHS..L..GIPWAP.LSSCSSQAPQL..TGCLSQLHSSLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DIADFATTI..WQ..QMEDLGM.AP..AL.....QP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASHLQRFLELAYRVLR..................................................
F7GL96_CALJA/65-166                  ......................................lvs--------------.......--..-------.--....--------..-..------.----------E..TGCLRQLHRGLFLYQGFLQTLEGISPEL..A..P.T..LDMLR.....L.DITDFATTI..WQ..QMEELGT.AP..AL.....QP..T...H..G..A......TP.A.LPSA....FQRQVGGLLVASHLQSFLELVHRVLR..................................................
H2R024_PANTR/51-199                  .........................................VRKIQGDGAALQEK.......LC..ATYKLCH.PE....ELVLLGHS..L..GIPWAP.LSSCPSQALQL..AGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DVADFATTI..WQ..QMEELGM.AP..AL.....QP..T...Q..G..A......MP.A.FASA....FQRRAGGVLVASHLQSFLEVSYRVLR..................................................
A0A2K5RS68_CEBCA/51-202              .........................................VRKVQGDGTELQEKl....vsEC..ATYKMCH.PE....EMVLFRRS..L..GIPQVS.LSSCPNQALQL..TGCLRQLHSGLFLYQGLLQTLEGISPEL..A..P.T..VDMLR.....L.DIADFATTI..WQ..QMEELGT.VP..AL.....QP..T...R..G..A......MP.A.LPSA....FQRRVGGLLVASHLQSFLELVHRVLR..................................................
A0A384BZE1_URSMA/42-190              .........................................MRKVQADGTALQER.......LC..ATYKLCH.PE....ELVLLGHA..L..GIPQPP.LSSCSSQALQL..TGCLRQLHGGLFLYQGLLQALAGISPEL..A..P.T..LDTLQ.....L.DISDFAVNI..WQ..QMEELGV.AP..AV.....PP..T...Q..G..T......MP.T.FTSS....FQRRAGGVLVTSDLQSFLELAYRALR..................................................
A0A1A6HM10_NEOLE/80-228              ........................................a-RKIQAGTSALLEQ.......LC..AIYKLCH.PE....ELVLLSHS..L..GIPQAP.LSHCSSQALQL..TKCLSQLHSGLFLYQGLLQALAGISPEL..A..P.S..LDMLQ.....L.DVANFATTI..WQ..QMENLGL.AP..AV.....QP..T...Q..S..T......MP.T.FTSS....FQRRAGGVLAXSHLQSFLEKAHCAL-n.................................................
CSF3_SHEEP/21-169                    .........................................VRKIQADGAELQER.......LC..ATHKLCH.PE....ELVLLGHS..L..GIPQAP.LSSCSSQSLQL..TSCLDQLHGGLFLYQGLLQALAGISPEL..A..P.T..LDTLQ.....L.DVTDFATNI..WL..QMEDLGV.AP..AV.....QP..T...Q..G..T......MP.T.FTSA....FQRRAGGVLVASQLQRFLGLAYRGLR..................................................
H0YVL5_TAEGU/1-137                   ........................................q--------------.......-C..DTLQLCK.ED....ELLLVRQE..L..DIAQAP.LEQCHRRTFQA..ETCFSQIRAGLRIYGGSLATIQALLPGH..A..G.L..VETLQ.....L.DMANLSSNI..QQ..QMEDLGL.AT..VT.....YPpeN...Q..D..P......VP.T.FSSH....FHHQVGGFFILANFQRFLETAYRALR..................................................
F7H1Q3_MACMU/47-195                  .........................................VRKIQGDGAALQEK.......LC..ATYKLCH.PE....ELVLLRHS..L..GIPWAP.LSSCPSQALQL..TGCLSQLHSSLFLYQGLLQALEGISPEL..S..P.T..LDTLQ.....L.DIADFATTI..WQ..QMEDLGM.AP..AL.....QP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASHLQRFLELAYRVLR..................................................
A0A2K5CMX6_AOTNA/51-202              .........................................VRKVQGDGTELQEKl....vsEC..ATYKLCH.PE....EMVLFRHS..L..GISQVS.LSSCPSQALQL..TGCLRQLHSGLFLYQGLLQTLEGISPEL..A..P.T..LDMLR.....L.DIADFATTI..WQ..QMEELGT.AP..AL.....QP..T...R..S..A......TP.A.LPSA....FQRRVGGLLVASHLQSFLELVHRVLR..................................................
G3QQS4_GORGO/51-202                  .........................................VRKIQGDGAALQEKl....vsEC..ATYKLCH.PE....ELVLLGHS..L..GIPWAP.LSSCPSQALQL..AGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DVTNFATTI..WQ..QMEELGM.AP..AL.....QP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASHLQSFLEVSYRVLR..................................................
Q8N4W3_HUMAN/47-195                  .........................................VRKIQGDGAALQEK.......LC..ATYKLCH.PE....ELVLLGHS..L..GIPWAP.LSSCPSQALQL..AGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DVADFATTI..WQ..QMEELGM.AP..AL.....QP..T...Q..G..A......MP.A.FASA....FQRRAGGVLVASHLQSFLEVSYRVLR..................................................
A0A1S3WLA0_ERIEU/42-190              .........................................VRKIQADSTALQEK.......LC..ATHRLCH.PE....ELVLLGHS..L..GIPQAR.LSRCSSQTLQL..MGCLDQLHRGLFLYQGLLQALAGVSPEL..A..P.T..VDLLH.....L.DIADFATNI..WQ..QMEDLGV.DP..AV.....KP..T...Q..G..T......MP.T.FTSA....FQRRAGGVLVASNLQSFLEGAYRALH..................................................
A0A3Q3LQQ8_9TELE/79-221              ...............................thkscihtgt--------------.......--..--LKLNS.SEn..aNLVIMASN..I..GIPSAP.VLKAVSENFTL..ETCLTQMSEGLQLYRALL---SSVSPRL..EnrD.T..VTELM.....A.DIRDLSIQI..SK..LLKMVQI.EV..VV.....QP..S...P..T..P......IAlR.LPGE....YEVQVAAHLTLVHLQAFG--------qdmvrclr..........................................
A0A1U7UFL0_TARSY/51-205              ........................................a-RKIQSDGTALQERlvs.drrTC..ATFKLCH.PE....ELVLLGHS..L..GIPRAP.LGSCTSQALQL..TGCLRQLHGGLFLYQGLLQALGGISPEL..A..T.A..LDGLR.....L.DVADFATTV..WH..QMEDLGV.AP..TL.....QP..T...Q..S..A......LP.T.FASA....FQRRAGGVLVASHLQSFLELAHRVLR..................................................
A0A452EPD7_CAPHI/43-191              .........................................VRKIQADGAELQER.......LC..ATHKLCH.PE....ELVLLGHS..L..GIPQAP.LSSCSSQSLQL..TSCLDQLHGGLFLYQGLLQALAGISPEL..A..P.T..LDTLQ.....L.DVTDFATNI..WL..QMEDLGV.AP..AV.....QP..T...Q..G..T......MP.T.FTSA....FQRRAGGVLVASQLQRFLGLAYRGLR..................................................
A0A452H1C5_9SAUR/48-199              .........................................IRKIKGDVAQVQEL.......VC..TTLQLCS.EE....ELMLVKQK..L..GISQAP.LDQCHSKTFQV..DACFSQIRDGLQIYHGHLALLLQLLPAH..S..S.R..VDALR.....L.DVSNLSTNI..QQ..QMEDLGL.NT..VT.....YP..KaegQ..G..T......LP.S.LSSN....FDRQASGFIIPANFKRFLETSLRALR..................................................
U3JCF4_FICAL/45-195                  ........................................t-RKIRGDVAALQRV.......VC..DTLQLCK.ED....ELVLVRQD..L..DIAQAP.LEQCHKRTFQA..ETCFSQIRAGLHIYHSSLATIQALLPGH..T..G.L..VETLQ.....L.DMANLSSNI..QQ..QMDDLGL.AT..VT.....YP..Te.nQ..D..P......LP.T.FSSN....FHHQVGGFFILANFQRFLETAYRALR..................................................
A0A2K6P8H6_RHIRO/60-159              ........................................k--------------.......--..-------.--....--------..-..------.----------L..TGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DIADFATTI..WQ..QMEDLGM.AP..AL.....QP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASHLQRFLELAYRVLR..................................................
G1SXQ9_RABIT/51-199                  .........................................VRKIQADTSMLQEE.......LC..ATHKLCH.PE....ELLLLGHS..L..GIPRAP.LSSCSSQALQL..PGCLSQLHSGLLLYRGLLQALAGISPAS..A..P.A..LDKLQ.....L.DVADFATTI..WH..QMEDLGQ.AP..AV.....QP..T...Q..S..T......MP.A.LTSA....FQRRAGSVLVASHLQSFLELTYRVLR..................................................
A0A2K5ZFP1_MANLE/51-202              .........................................VRKIQGDGAALQEKl....vsEC..ATYKLCH.PE....ELVLLRHS..L..GIPWAP.LSSCPSQALQL..TGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DVADFATTI..WQ..QMEDLGM.AP..AL.....QP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASHLQRFLELAYRVLR..................................................
A0A1S3GX54_DIPOR/53-204              .........................................VRKIQAEGTELLEAl....vsEC..TTYKLCH.PE....ELALLGHS..L..GIPHAP.LSSCTSQGLQP..EGCLSQLHSGLVLYQSLLQALAGISAEV..S..P.A..LDMLQ.....L.DVTNFAITI..WQ..QMEDLGV.AP..EV.....KP..I...Q..G..T......MP.A.FTSA....FQRRAGGVLVISNLQNFLELAYRVLR..................................................
A0A1L8ERX3_XENLA/65-210              ........................................s-RKITRDAEKLISH.......MC..GDDGWCE.KS....QLTFIQKH..L..QLQDVP.LDQCQAGSFSQ..EGCFSQLFNGLKELQKWVLAMPGHLPE-..-..G.N..LHRLN.....K.DISDLLVNI..QE..EMEAQGI.KA..QS.....SP..S...Q..T..L......LP.T.GASN....FHKRVAMFLILSDLVNFMGI------lhgll.............................................
CSF3_HUMAN/51-202                    .........................................VRKIQGDGAALQEKl....vsEC..ATYKLCH.PE....ELVLLGHS..L..GIPWAP.LSSCPSQALQL..AGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DVADFATTI..WQ..QMEELGM.AP..AL.....QP..T...Q..G..A......MP.A.FASA....FQRRAGGVLVASHLQSFLEVSYRVLR..................................................
#=GR CSF3_HUMAN/51-202         SS    .........................................HHHHHHHHHHHHHHH....XXXH..HHHT---.GG....GGHHHHHH..H..T-----.STTSSSSSSTH..HHHHHHHHHHHHHHHHHHHHTTTSSTTT..H..H.H..HHHHH.....H.HHHHHHHHH..HH..HHHHTT-.S-..SS.....--..S...S..S..-......-S.-.--SH....HHHHHHHHHHHHHHHHHHHHHHHHHH..................................................
CSF3_FELCA/41-189                    .........................................VRKVQADGTALQER.......LC..AAHKLCH.PE....ELVLLGHA..L..GIPQAP.LSSCSSQALQL..TGCLRQLHSGLFLYQGLLQALAGISPEL..A..P.T..LDMLQ.....L.DITDFAINI..WQ..QMEDVGM.AP..AV.....PP..T...Q..G..T......MP.T.FTSA....FQRRAGGTLVASNLQSFLEVAYRALR..................................................
A0A2K5TUV9_MACFA/47-195              .........................................VRKIQGDGAALQEK.......LC..ATYKLCH.PE....ELVLLRHS..L..GIPWAP.LSSCPSQALQL..TGCLSQLHSSLFLYQGLLQALEGISPEL..S..P.T..LDTLQ.....L.DIADFATTI..WQ..QMEDLGM.AP..AL.....QP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASHLQRFLELAYRVLR..................................................
A0A226NQK2_COLVI/1-136               .........................................--------------.......-C..DTFQLCA.EE....ELRLVQQD..L..PLTQPP.LEQCHSRGFQA..EVCFGQIHAGLRAYQGSLGAVLLLLPEH..T..A.L..VETLQ.....L.DTANLSSNI..QQ..QMEDLGL.DA..VT.....PP..A...EqrS..P......PP.A.FSSP....FQQQVGGFFILANFQRFLETAYRALR..................................................
A0A2I3N0F9_PAPAN/65-166              ......................................lvs--------------.......--..-------.--....--------..-..------.----------E..TGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DVADFATTI..WQ..QMEDLGM.AP..AL.....QP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASHLQRFLELAYRVLR..................................................
M3YU08_MUSPF/51-199                  .........................................MRKVQADSTVLQER.......LC..ATHKLCH.PE....ELVLLGHA..L..GIPQPS.LSGCSSHALQL..TGCLRQLHNGLVLYQGLLQALTGLPPEL..T..P.A..LETLQ.....L.DIGDFAINL..WR..EMEELGV.AP..AV.....PP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASNLQSFLELAYRALR..................................................
A0A2U3VJM2_ODORO/42-190              .........................................MRKVQADGTVLQER.......LC..ATHKLCH.PE....ELVLLGHA..L..GIPQPP.LSSCSSQALQL..TGCLHQLHSGLVLYQGLLQALAGITPEL..A..P.T..LDMLQ.....L.DISDFAFNI..WQ..QMEELGL.AQ..AV.....PP..S...Q..G..T......MP.T.FTSA....FERRAGGVLVASSLQSFLELAYRALR..................................................
A0A2K5MBQ8_CERAT/65-166              ......................................lvs--------------.......--..-------.--....--------..-..------.----------E..TGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DVADFATTI..WQ..QMEDLGM.AP..AL.....QP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASHLQRFLELAYRVLR..................................................
G3WLV1_SARHA/68-216                  .........................................VRKIQNDIEGLQQR.......LC..ADYRLCH.PE....ELILVGLY..L..GIPRPS.VKNCYSQDLKL..VACLNQLYYGLQFYQGLVRALEGISPEL..A..P.T..LDTLK.....L.DIGDFAASI..WQ..QMEDFQV.VP..EI.....VP..T...Q..S..I......LP.T.FSSS....FYRRAGGVLIFSQLQSFLDMAYRALR..................................................
I3M5J4_ICTTR/53-205                  .........................................VRKIQAQGSVLQEKlv...seTC..ATYQLCH.PE....ELALLGHS..L..GIPQAP.LSNCSSQGLQL..TGCLSQLQSGLFLYQGLLQALAGISPEL..S..P.T..VDMLQ.....L.DVANFATTV..WQ..QMEDLGV.AP..AV.....QP..T...Q..G..T......MP.T.FTSA....FQRRAVGVLVASRLQRLLELVYRVLR..................................................
J3KTH8_HUMAN/60-159                  ........................................k--------------.......--..-------.--....--------..-..------.----------L..AGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DVADFATTI..WQ..QMEELGM.AP..AL.....QP..T...Q..G..A......MP.A.FASA....FQRRAGGVLVASHLQSFLEVSYRVLR..................................................
A0A2K6P8H9_RHIRO/51-199              .........................................VRKIQGDGAALQEK.......LC..ATYKLCH.PE....ELVLLRHS..L..GIPWAP.LSSCPSQALQL..TGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DIADFATTI..WQ..QMEDLGM.AP..AL.....QP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASHLQRFLELAYRVLR..................................................
A0A452RK93_URSAM/42-190              .........................................MRKVQADGTALQER.......LC..ATYKLCH.PE....ELVLLGHA..L..GIPQPP.LSSCSSQALQL..TGCLRQLHGGLFLYQGLLQALAGISPEL..A..P.T..LDTLQ.....L.DISDFAVNI..WQ..QMEELGV.AP..AV.....PP..T...Q..G..T......MP.T.FTSS....FQRRAGGVLVTSDLQSFLELAYRALR..................................................
A0A3L8RZ37_CHLGU/42-192              ........................................t-RKIRGDVAALQRV.......VC..DTLQLCK.ED....ELLLVRQD..L..DIAQAP.LEQCHRRTFQA..ETCFSQIRAGLRIYHGSLAAIQALLPGH..A..G.L..VETLQ.....L.DMANLSSNI..QQ..QMEDLGL.AT..VT.....YP..Te.nQ..D..P......VP.T.FSSH....FHHQVGGFFILANFQRFLETAYRALR..................................................
L5JTJ0_PTEAL/42-190                  .........................................VRKIQADGVVLQER.......LC..ATHNLCH.PE....ELVLLGHS..L..GISQAP.LSSCSSQALQL..TGCLRQLHSGLFLYQGFLQALAGISPKL..A..P.T..LDMLH.....L.DIADLATNI..WQ..QMEDLGV.AP..AV.....QA..T...Q..G..T......MP.I.FTSA....FQRRAGGVLVAANLQSFLELAYRVLR..................................................
A0A2K5TUW1_MACFA/65-166              ......................................lvs--------------.......--..-------.--....--------..-..------.----------E..TGCLSQLHSSLFLYQGLLQALEGISPEL..S..P.T..LDTLQ.....L.DIADFATTI..WQ..QMEDLGM.AP..AL.....QP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASHLQRFLELAYRVLR..................................................
A0A2K6P8I2_RHIRO/47-195              .........................................VRKIQGDGAALQEK.......LC..ATYKLCH.PE....ELVLLRHS..L..GIPWAP.LSSCPSQALQL..TGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DIADFATTI..WQ..QMEDLGM.AP..AL.....QP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASHLQRFLELAYRVLR..................................................
A0A2K5RS65_CEBCA/47-195              .........................................VRKVQGDGTELQEK.......LC..ATYKMCH.PE....EMVLFRRS..L..GIPQVS.LSSCPNQALQL..TGCLRQLHSGLFLYQGLLQTLEGISPEL..A..P.T..VDMLR.....L.DIADFATTI..WQ..QMEELGT.VP..AL.....QP..T...R..G..A......MP.A.LPSA....FQRRVGGLLVASHLQSFLELVHRVLR..................................................
A0A3P8Y1V0_ESOLU/33-190              .......sqnlikkvleaipgthkscihsetlilnsttenr--------------.......--..-------.--....KLQYMATN..L..GIPSAP.TLKALAEDFTL..ETCLRHMSEGLQLHQDLLKAV---QPRL..S..N.TenLTALM.....T.DIRDLGIQI..NK..MLRAVQA.EV..TL.....QP..T...V..T..S......LA.SrLTGD....YQVQVAAHLTLVQLQSFGQDIVRSL-r.................................................
A0A455B220_PHYMC/42-190              .........................................VRKIQADGAELQER.......LC..TTHKLCH.PE....ELVLLGHS..L..GIPQAS.LSSCSSQALQL..TGCLSQLHGGLFLYQGLLQALAGISPEL..A..P.T..LDILQ.....L.DVTDFATNI..WL..QMEDLGV.AP..AV.....QP..T...Q..G..P......TP.T.FTSA....FQRRAGGVLVASKLQSFLELAYRVLR..................................................
A0A151P5I2_ALLMI/1-149               ....................................mdvet----------VRQH.......MC..DNFQLCK.EE....ELMLVKQN..L..NIFQPS.LNQCLSKPFQV..DVCFSQIREGLQTYHGYLSTIAQLLPGH..S..T.Q..VEGLQ.....L.DTSNLSTNI..QQ..QIEALGL.NM..GMvtypkEE..G...Q..G..T......LL.T.FSSQ....FYQQAGGYIILANFQLFLDLAYRVLR..................................................
A0A383ZRC8_BALAS/42-190              .........................................VRKIQADGTELQER.......LC..TTHKLCH.PE....ELVLLGHS..L..GIPQAS.LSSCSSQALQL..TGCLSQLHGGLFLYQGLLQALAGISPEL..A..P.T..LDILQ.....L.DVTDFATNI..WL..QMEDLGV.AP..AV.....QP..T...Q..G..P......MP.T.FTSA....FQRRAGGVLVASKLQSFLELAYRVLR..................................................
A0A1S3GWV7_DIPOR/53-201              .........................................VRKIQAEGTELLEA.......LC..TTYKLCH.PE....ELALLGHS..L..GIPHAP.LSSCTSQGLQP..EGCLSQLHSGLVLYQSLLQALAGISAEV..S..P.A..LDMLQ.....L.DVTNFAITI..WQ..QMEDLGV.AP..EV.....KP..I...Q..G..T......MP.A.FTSA....FQRRAGGVLVISNLQNFLELAYRVLR..................................................
A0A1U7QNT5_MESAU/84-232              .........................................VRKIQTRNSELLEQ.......LC..ATYKLCH.PE....ELVLLGHS..L..GILQAP.LSRCSIQALQP..TKCLSQLHSGLFLYQGLLQALAGISPEV..A..P.T..LDMLQ.....L.DVANFATTI..WQ..QMETLGV.AP..TV.....QP..T...Q..S..T......LP.T.FTSA....FQRRAGGVLTVSHLQTFLETAHCAL-n.................................................
A0A2K5JMV2_COLAP/51-202              .........................................VRKIQGDGAALQEKl....vsEC..ATYKLCH.PE....ELVLLRHS..L..GIPWAP.LSSCPSQALQL..TGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DVADFATTI..WQ..QMEDLGM.AP..AL.....QP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASHLQRFLELVYRVLR..................................................
A0A340XVI9_LIPVE/42-190              .........................................VRKIQADGADLQER.......LC..TTHKLCH.PE....ELVLLGHS..L..GIPQAS.LSSCSSQTLQL..TGCLRQLHGGLFLFQGLLQALAGISPEL..A..P.T..LDILQ.....L.DVTDFATNI..WL..QMEDLGV.AP..AV.....QP..T...Q..G..P......MP.T.FTSA....FQRRAGGVLVASKLQSFLELAYRVLR..................................................
A0A1U7UBL4_TARSY/67-169              .....................................sdrr--------------.......--..-------.--....--------..-..------.----------T..TGCLRQLHGGLFLYQGLLQALGGISPEL..A..T.A..LDGLR.....L.DVADFATTV..WH..QMEDLGV.AP..TL.....QP..T...Q..S..A......LP.T.FASA....FQRRAGGVLVASHLQSFLELAHRVLR..................................................
A0A1L8EKK4_XENLA/64-206              ........................................s-RKIIRDAERLIND.......LC..RNEGWCE.KS....QLTFFQ--..-..-LQDVP.LDQCQAGSFSQ..EGCFSQLSNGLMELQRRVMAMPGHLPK-..-..E.N..LQRLE.....K.DISDLFVNI..QE..EMEAQGI.TA..QN.....SP..S...Q..T..S......LP.T.STST....FHQKATMFLILSDLADFMRT------lhslla............................................
A0A087QGK3_APTFO/1-137               ........................................q--------------.......-C..DTFQLCK.EE....ELLLVRQD..L..GIVQVP.LEQCHSRNFQA..EACFSQIHDGLRAYHGSLAAVLELLPGH..T..S.L..VETLQ.....L.DAANLSSNI..QQ..QMEDLGL.AT..VT.....YP..T...E..GpgP......LP.T.FSSS....FHHQVGGFFILANFQRFLETAYRALR..................................................
W5PSS6_SHEEP/42-195                  .........................................VRKIQADGAELQER.......LVrrVGRRRCG.GG....EVGALGEEeeLapHIPQAP.LSSCSSQSLQL..VS-VPRLHAGALRPPSLRRALAGISPEL..A..P.T..LDTLQ.....L.DVTDFATNI..WL..QMEDLGV.AP..AV.....QP..T...Q..G..T......MP.T.FTSA....FQRRAGGVLVASQLQRFLGLAYRGLR..................................................
H9KVK4_CALJA/51-202                  .........................................VRKVQGDGTELQEKl....vsEC..ATYKMCH.PE....EMVLFRHS..L..GIPQVS.LSSCPSQALQL..TGCLRQLHRGLFLYQGFLQTLEGISPEL..A..P.T..LDMLR.....L.DITDFATTI..WQ..QMEELGT.AP..AL.....QP..T...H..G..A......TP.A.LPSA....FQRQVGGLLVASHLQSFLELVHRVLR..................................................
CSF3_BOVIN/42-190                    .........................................VRKIQADGAELQER.......LC..AAHKLCH.PE....ELMLLRHS..L..GIPQAP.LSSCSSQSLQL..TSCLNQLHGGLFLYQGLLQALAGISPEL..A..P.T..LDTLQ.....L.DVTDFATNI..WL..QMEDLGA.AP..AV.....QP..T...Q..G..A......MP.T.FTSA....FQRRAGGVLVASQLHRFLELAYRGLR..................................................
#=GR CSF3_BOVIN/42-190         SS    .........................................HHHHHHHHHHHHHH.......HH..HHH----.HH....HHHTTHHH..H..T-----.-GGGSTTT--H..HHHHHHHHHHHHHHHHHHHHTTTSSTTT..H..H.H..HHHHH.....H.HHHHHHHHH..HH..HHHHHS-.--..--.....--..-...-..-..-......--.-.--SH....HHHHHHHHHHHHHHHHHHHHHHHHHH..................................................
A0A2K5ZFL0_MANLE/65-166              ......................................lvs--------------.......--..-------.--....--------..-..------.----------E..TGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DVADFATTI..WQ..QMEDLGM.AP..AL.....QP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASHLQRFLELAYRVLR..................................................
L9JXF3_TUPCH/38-185                  .........................................VRKIQMASAELQEK.......LC..ATYKLCH.PE....ELVLLGHS..L..GIPQAS.LSSCSSQALQL..TGCLSQLHSGLLLHQGLLQALAGISPKL..A..L.S..VDMLQ.....L.DVADFASTV..WQ..QMEDLGV.AS..AM.....RP..T...Q..G..T......MP.T.FASA....FQRRAGGVLVISHLQSFLGLAH----hfq...............................................
A0A2I2UX56_FELCA/51-199              .........................................VRKVQADGTALQER.......LC..AAHKLCH.PE....ELVLLGHA..L..GIPQAP.LSSCSSQALQL..TGCLRQLHSGLFLYQGLLQALAGISPEL..A..P.T..LDMLQ.....L.DITDFAINI..WQ..QMEDVGM.AP..AV.....PP..T...Q..G..T......MP.T.FTSA....FQRRAGGTLVASNLQSFLEVAYRALR..................................................
G1NZX6_MYOLU/51-199                  .........................................VRKIQADVVAMQER.......LC..ATHKLCH.PE....ELVLLRHS..L..GIPQVP.LGSCSSQALQL..TSCLGQLHGGLFLYQGLLQALAGISPEL..G..P.T..LDMLQ.....L.DITDFATNI..WQ..QMEDLGM.AP..GV.....QA..T...Q..G..T......VP.T.FTSA....FQRRAGGVLVASSLQSFLQLALRVLR..................................................
A0A2I3T1Y4_PANTR/64-166              .....................................klvs--------------.......--..-------.--....--------..-..------.----------E..AGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DVADFATTI..WQ..QMEELGM.AP..AL.....QP..T...Q..G..A......MP.A.FASA....FQRRAGGVLVASHLQSFLEVSYRVLR..................................................
A0A3Q7S1A7_VULVU/42-190              .........................................MRKVQADGTALQET.......LC..ATHQLCH.PE....ELVLLGHA..L..GIPQPP.LSSCSSQALQL..MGCLRQLHSGLFLYQGLLQALAGISPEL..A..P.T..LDTLQ.....L.DITDFAINI..WQ..QMEDLGM.AP..AV.....PP..T...Q..G..T......MP.A.FTSA....FQRRAGGVLVASNLQSFLELAYRALR..................................................
A0A0Q3X8P5_AMAAE/15-73               ..................................vvacpda--------------.......--..-------.--....--------..-..------.-----------..----------------------------..-..-.-..-----.....-.---------..--..GMEDLGL.AT..VT.....YP..Me.aR..G..P......LP.A.FPSH....FHHQVGSFFILADFQRFLETAYRALR..................................................
H0VSM3_CAVPO/56-204                  ........................................a-RRVQAEAMVMQEK.......LC..ATHRLCH.PE....ELALLGHS..L..GIPWAS.LRSCSSRDLQL..LGCLRQLQAGLMLYQGLLQALAGISPAL..S..S.S..VDLLR.....L.DVADFATTV..WQ..QMEDLGV.AP..AA.....QP..T...L..G..T......VP.A.FTSA....FQRQAGGVLVASHLQDFLELALRALR..................................................
A0A1U7U5G1_TARSY/51-199              ........................................a-RKIQSDGTALQER.......LC..ATFKLCH.PE....ELVLLGHS..L..GIPRAP.LGSCTSQALQL..TGCLRQLHGGLFLYQGLLQALGGISPEL..A..T.A..LDGLR.....L.DVADFATTV..WH..QMEDLGV.AP..TL.....QP..T...Q..S..A......LP.T.FASA....FQRRAGGVLVASHLQSFLELAHRVLR..................................................
A0A493T676_ANAPP/48-198              ........................................t-RKIKGDVAALQRV.......VC..DTFQLCK.EE....ELLLVQQD..L..RITQVA.LEQCHRPSFQA..EACFSQIRHGLHAYHSSLAAVLELLPSH..A..G.L..VETLQ.....L.DAANLSSNI..QQ..QMEDLGL.AT..VT.....FP..A...EdhG..P......LP.A.FSSR....FQHQVGGFLILANFQRFLETAYRALR..................................................
A0A3M0JRR3_HIRRU/538-688             ........................................t-RKIRGDVAALQRV.......VC..DTFQLCK.ED....ELLLVRQD..L..DIAQVP.LEQCHKRSFQA..ETCFSQIRAGLRVYHGSLATIRALLPGH..S..G.L..VETLQ.....L.DMANLSSNI..QQ..QMEDLGL.AT..VT.....YP..Se.nQ..D..P......LP.T.FSSH....FHHQVGGFFILANFQRFLETAYRALR..................................................
A0A4D9ETT6_9SAUR/27-178              .........................................IRKIKGDVAQVQDL.......VC..TTFQLCN.EE....ELMLVKQK..L..GISQAP.LDQCHSKTFQV..DACFSQIRDGLQIYHGHLALLLQLLPAH..S..G.L..VDALR.....L.DVSNLSTNI..QQ..QMEDLGL.NT..VT.....YP..KaegQ..G..T......LP.S.LSSD....FDKQASGFIILANFKRFLETSLRALR..................................................
A0A2R8ZJQ3_PANPA/51-199              .........................................VRKIQGDGAALQEK.......LC..ATYKLCH.PE....ELVLLGHS..L..GIPWAP.LSSCPSQALQL..AGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DVADFATTI..WQ..QMEELGM.AP..AL.....QP..T...Q..G..A......MP.A.FASA....FQRRAGGVLVASHLQSFLEVSYRVLR..................................................
A0A3Q7XQE4_URSAR/42-190              .........................................MRKVQADGTALQER.......LC..ATYKLCH.PE....ELVLLGHA..L..GIPQPP.LSSCSSQALQL..TGCLRQLHGGLFLYQGLLQALAGISPEL..A..P.T..LDTLQ.....L.DISDFAVNI..WQ..QMEELGV.AP..AV.....PP..T...Q..G..T......MP.T.FTSS....FQRRAGGVLVTSDLQSFLELAYRALR..................................................
G3INY3_CRIGR/57-205                  .........................................VRKIQTRNSELLEQ.......LC..ATYKLCH.PE....ELVLLGHS..L..GIPQAP.LSRCSIQALQL..TKCLSQLHSGLFLYQGLLQALTGISPEL..A..P.T..VDMLQ.....L.DVANFATTI..WQ..QMESLGV.AP..TV.....QP..T...Q..S..T......LP.T.FTSA....FQRRAGGVLAASHLQSFLETAHCTL-n.................................................
A0A2K5RS88_CEBCA/65-166              ......................................lvs--------------.......--..-------.--....--------..-..------.----------E..TGCLRQLHSGLFLYQGLLQTLEGISPEL..A..P.T..VDMLR.....L.DIADFATTI..WQ..QMEELGT.VP..AL.....QP..T...R..G..A......MP.A.LPSA....FQRRVGGLLVASHLQSFLELVHRVLR..................................................
G3PPJ2_GASAC/44-197                  ....................vdkilrdvsivhsatvtmegl--------------.......--..-TLDSAH.PT....NLQMMVTS..L..GIPPAP.VLKPLSEHFTL..DVCVSRMSSGILLYQRLLGVLSD----R..V..S.G..LSDLQ.....A.DLRDLQTHV..AT..VREVAQLrDP..EL.....DE..N...Q..N..Q......RP.D.LASRlhgnYKVQIATHLTLTHLRSF---------chdlirslr.........................................
CSF3_PIG/42-190                      .........................................VRKIQADGAELQER.......LC..ATHKLCH.PQ....ELVLLGHS..L..GLPQAS.LSSCSSQALQL..TGCLNQLHGGLVLYQGLLQALAGISPEL..A..P.A..LDILQ.....L.DVTDLATNI..WL..QMEDLRM.AP..AS.....LP..T...Q..G..T......VP.T.FTSA....FQRRAGGVLVVSQLQSFLELAYRVLR..................................................
A0A226N813_CALSU/46-196              ........................................t-RKIRGDVAALQRV.......VC..DTFQLCA.EE....ELRLVQQD..L..PLTQPR.LEQCHSRGFQA..EVCFGQIHAGLRAYQGSLGAVLLLLPEH..T..A.L..VETLQ.....L.DTANLSSNI..QQ..QMEDLGL.DA..VT.....PP..A...EqrS..P......PP.A.FSSR....FQQQVGGFFILANFQRFLETAYRALR..................................................
A0A2K5TUV5_MACFA/51-202              .........................................VRKIQGDGAALQEKl....vsEC..ATYKLCH.PE....ELVLLRHS..L..GIPWAP.LSSCPSQALQL..TGCLSQLHSSLFLYQGLLQALEGISPEL..S..P.T..LDTLQ.....L.DIADFATTI..WQ..QMEDLGM.AP..AL.....QP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASHLQRFLELAYRVLR..................................................
A0A2U3Z1Q3_LEPWE/42-190              .........................................MRKVQADGTVLQER.......LC..ATHKLCH.PE....ELVLLGHA..L..GIPQPP.LSSCSSQALQL..TGCLRQLHSGLVLYQGLLQALAGITPEL..A..P.T..LDMLQ.....L.DISDFALNI..WQ..QMEELGL.AQ..AV.....PP..S...Q..G..T......MP.T.FTSA....FERRAGGVLVASNLQSFLELAYRTLR..................................................
J3QRX2_HUMAN/64-155                  ........................................k--------------.......--..-------.--....--------..-..------.----------L..AGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DVADFATTI..WQ..QMEELGM.AP..AL.....QP..T...Q..G..A......MP.A.FASA....FQRRAGGVLVASHLQSFL--------..................................................
A0A096P5E3_PAPAN/51-202              .........................................VRKIQGDGAALQEKl....vsEC..ATYKLCH.PE....ELVLLRHS..L..GIPWAP.LSSCPSQALQL..TGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DVADFATTI..WQ..QMEDLGM.AP..AL.....QP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASHLQRFLELAYRVLR..................................................
MGF_CHICK/46-196                     ........................................t-RKIRGDVAALQRA.......VC..DTFQLCT.EE....ELQLVQPD..P..HLVQAP.LDQCHKRGFQA..EVCFTQIRAGLHAYHDSLGAVLRLLPNH..T..T.L..VETLQ.....L.DAANLSSNI..QQ..QMEDLGL.DT..VT.....LP..A...EqrS..P......PP.T.FSGP....FQQQVGGFFILANFQRFLETAYRALR..................................................
A0A452EPF0_CAPHI/73-221              .........................................VRKIQADGAELQER.......LC..ATHKLCH.PE....ELVLLGHS..L..GIPQAP.LSSCSSQSLQL..TSCLDQLHGGLFLYQGLLQALAGISPEL..A..P.T..LDTLQ.....L.DVTDFATNI..WL..QMEDLGV.AP..AV.....QP..T...Q..G..T......MP.T.FTSA....FQRRAGGVLVASQLQRFLGLAYRGLR..................................................
A0A2K6T175_SAIBB/65-166              ......................................lvs--------------.......--..-------.--....--------..-..------.----------E..TGCLRQLHSGLFLYQGLLQTLEGISPEL..A..P.T..LDMLR.....L.DIADFATTI..WQ..QMEELGT.AP..AL.....QP..T...R..G..A......TP.A.LPSA....FQRRVGGLLVASHLQSFLELVHRVLR..................................................
A0A1D5R4Y8_MACMU/65-166              ......................................lvs--------------.......--..-------.--....--------..-..------.----------E..TGCLSQLHSSLFLYQGLLQALEGISPEL..S..P.T..LDTLQ.....L.DIADFATTI..WQ..QMEDLGM.AP..AL.....QP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASHLQRFLELAYRVLR..................................................
A0A452EN91_CAPHI/55-203              .........................................VRKIQADGAELQER.......LC..ATHKLCH.PE....ELVLLGHS..L..GIPQAP.LSSCSSQSLQL..TSCLDQLHGGLFLYQGLLQALAGISPEL..A..P.T..LDTLQ.....L.DVTDFATNI..WL..QMEDLGV.AP..AV.....QP..T...Q..G..T......MP.T.FTSA....FQRRAGGVLVASQLQRFLGLAYRGLR..................................................
A0A2K6KWG7_RHIBE/51-199              .........................................VRKIQGDGAALQEK.......LC..ATYKLCH.PE....ELVLLRHS..L..GIPWAP.LSSCPSQALQL..TGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DIADFATTI..WQ..QMEDLGM.AP..AL.....QP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASHLQRFLELAYRVLR..................................................
A0A3Q0GKF4_ALLSI/77-230              ........................................t-RKIKMDVETMRQH.......MC..DNFQLCK.EE....ELMLVKQN..L..NIFQPS.LNQCLSKPFQV..DVCFSQIREGLQTYHGYLSTIAQLLPGH..S..T.Q..VEGLQ.....L.DTSNLSTNI..QQ..QVEALGL.NM..GMvtypkEE..G...Q..G..T......LL.T.FSSQ....FYQQAGGYIVLANFQLFLDLAYRVLR..................................................
A0A091V0J9_NIPNI/30-154              ......................qlflhknleftrkikgdva--------------.......--..-------.--....--------..-..------.-------ALQRvvEACFSQIRDGLRAYHGSLAAVLELRPGD..A..S.L..VETLQ.....P.DAANLSSNI..QQ..QMEDLGL.AT..VT.....YP..T...E..GpdA......LP.A.FSSS....FHHQVGGFFILANFQRFLETAYRALR..................................................
H3B4W7_LATCH/58-207                  .......................................ae--KIHPEIKNLQDL.......IC..KQHHICN.ED....ELTLKKEY..L..RIPHPR.LEECRSNNLQL..DTCMNKMEAGLQVYGDYLNLIKKVIVG-..S..S.L..AETVQ.....A.DIMDLQQHI..RQ..KVIDVAI.LVlhVG.....MH..P...Q..Y..T......LP.N.FAAS....FDEQAGGHIVLSHFKRFMETVLRVL-q.................................................
A0A2K5JMV7_COLAP/65-166              ......................................lvs--------------.......--..-------.--....--------..-..------.----------E..TGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DVADFATTI..WQ..QMEDLGM.AP..AL.....QP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASHLQRFLELVYRVLR..................................................
F7CRM4_MONDO/51-206                  .........................................VRKIQMDMEELQQRlnlisaiQC..ADYSLCH.PE....ELILVGQY..L..GIPRPP.LKNCYSQDLRL..AACLNQLHDGLQLYQELLKALQGISPEL..A..P.T..LDTLQ.....L.DVADFTATI..WL..QMEDLQV.TP..KI.....MP..I...L..G..T......LP.S.FSSS....FWRRAGGILIFDRLQAFLETAYRALR..................................................
A0A2R8ZKP4_PANPA/64-166              .....................................klvs--------------.......--..-------.--....--------..-..------.----------E..AGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DVADFATTI..WQ..QMEELGM.AP..AL.....QP..T...Q..G..A......MP.A.FASA....FQRRAGGVLVASHLQSFLEVSYRVLR..................................................
A0A1U7UNR8_TARSY/60-163              .....................................alqe--------------.......--..-------.--....--------..-..------.---------RL..TGCLRQLHGGLFLYQGLLQALGGISPEL..A..T.A..LDGLR.....L.DVADFATTV..WH..QMEDLGV.AP..TL.....QP..T...Q..S..A......LP.T.FASA....FQRRAGGVLVASHLQSFLELAHRVLR..................................................
Q8MKE0_HORSE/1-122                   .........................................--------------.......--..-------.--....--MLLGHS..L..GIPQPL.LSSCSSQALQL..TGCLSQLHSGLLLYQGLLQALAGISPEL..A..P.T..LDMLQ.....L.DVTDFATNI..WQ..QMEDLGV.AP..VV.....QP..T...H..G..P......MP.T.FASA....FQRRAGGVLVASNLQRFLELAYRGLR..................................................
A0A1V4JQZ4_PATFA/47-197              ........................................t-RKIKGDVAALQRV.......VC..DTFQLCQ.EE....ELLLVRQD..L..GIAQAP.LEQCHSRSFHA..EACFSQIRSGLRVYQGSLAAVRELLPSH..A..A.L..VETLQ.....L.DAANLSSNI..QQ..QVEDLGL.AT..VT.....LP..A...EdrD..P......LP.A.FSSR....FHHQVGGFFILANFQRFLETAYRALR..................................................
G1QLG1_NOMLE/65-166                  ......................................lvs--------------.......--..-------.--....--------..-..------.----------E..TGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DVADFATTI..WQ..QMEELGM.AP..AL.....QP..T...Q..G..A......MP.A.FASA....FQRRAGGVLVASHLQSFLELVYRVLR..................................................
CSF3_MOUSE/57-205                    .........................................VRKIQASGSVLLEQ.......LC..ATYKLCH.PE....ELVLLGHS..L..GIPKAS.LSGCSSQALQQ..TQCLSQLHSGLCLYQGLLQALSGISPAL..A..P.T..LDLLQ.....L.DVANFATTI..WQ..QMENLGV.AP..TV.....QP..T...Q..S..A......MP.A.FTSA....FQRRAGGVLAISYLQGFLETARLALH..................................................
A0A2Y9K8B4_ENHLU/42-190              .........................................MRKVQADSTVLQER.......LC..ATHKLCH.PE....ELVLLGHA..L..GIPQPS.LSGCSSQALQL..TGCLRQLHSALVLYQGLLQALTGLPPEL..T..P.A..LETLQ.....L.DIGDFAINL..WR..EMEELGV.AP..AV.....PP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASNLQSFLELAYRALR..................................................
A0A3B3QFB9_9TELE/47-200              ..............vnkilgdipaahkasvnsetltlqpns--------------.......--..------E.PK....NLDYMVTV..L..AIPSAP.TLKAISADFTV..EMCLDRMAEGLEMYQDLLKAVGDRA-SS..P..E.K..LRDLQ.....A.DVKDLSAQI..HK..MHQLAGM.ES..TA.....QY..K...G..S..G......LD.SrLTGD....YEVQVATHLTLAQLRDFTQDIFRSLR..................................................
A0A2Y9LVQ5_DELLE/42-190              .........................................VRKIQADGAELQER.......LC..TTHKLCH.PE....ELVLLGHS..L..GIPQAS.LSSCSSQTLQL..TACLSQLHGGLFLYQGLLQALAGISPEL..A..P.T..LDILQ.....L.DVTDFATNI..WL..QMEDLGV.AP..AV.....QP..T...Q..G..P......MP.T.FTSA....FQRRAGGVLVASKLQSFLELAYRVLR..................................................
F6RBW9_ORNAN/1-135                   .........................................--------------.......-C..TKHSLCH.PE....ELELMRHY..L..GVRQAS.VNRCPSRDLEL..GPCLKQLARGLKLYQAQLEALEGISPQL..A..P.A..LDTLQ.....L.DVRDFAINI..WQ..QLEDLRLtAG..TP.....LS..P...Q..A..S......VP.T.FTSA....FQRRAGAVLVLDNLQGFLEVVARVL-n.................................................
A0A091DWP2_FUKDA/333-481             ........................................a-RRVQAKALEMQQK.......LC..ATYKLCH.PE....ELALLGHS..L..GILWVP.LRGCSSQDLQP..TRCLHQLQAGLVLYRGLLHALGGISPGL..S..P.T..VDTLQ.....L.DVTDFATTI..WQ..QMEDLGV.AP..AV.....QP..T...P..G..A......VP.T.FTSA....FQRQVGGALLAWQLQRFLELGYRALR..................................................
A0A3Q3VKR8_MOLML/51-197              .....................lrdistvhaatintegltle--------------.......--..---NSAH.TT....NLQMMATS..L..GLPAAP.VLKPPSEHFTL..DICVSRMWVGSRLYQGLLGVLS---DRL..-..S.G..LDDLR.....A.DLRDLLTQI..NK..MKEAASL.--..--.....--..-...-..-..-......--.-.----....--------------------------dggvldqklelasrlhgnyevqvathltltqlrsfchdlmrslr......
F7H1Q6_MACMU/51-202                  .........................................VRKIQGDGAALQEKl....vsEC..ATYKLCH.PE....ELVLLRHS..L..GIPWAP.LSSCPSQALQL..TGCLSQLHSSLFLYQGLLQALEGISPEL..S..P.T..LDTLQ.....L.DIADFATTI..WQ..QMEDLGM.AP..AL.....QP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASHLQRFLELAYRVLR..................................................
A0A2K6KWH4_RHIBE/65-166              ......................................lvs--------------.......--..-------.--....--------..-..------.----------E..TGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DIADFATTI..WQ..QMEDLGM.AP..AL.....QP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASHLQRFLELAYRVLR..................................................
A0A2K6B759_MACNE/65-166              ......................................lvs--------------.......--..-------.--....--------..-..------.----------E..TGCLSQLHSSLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DIADFATTI..WQ..QMEDLGM.AP..AL.....QP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASHLQRFLELAYRVLR..................................................
A0A452EN95_CAPHI/27-175              .........................................VRKIQADGAELQER.......LC..ATHKLCH.PE....ELVLLGHS..L..GIPQAP.LSSCSSQSLQL..TSCLDQLHGGLFLYQGLLQALAGISPEL..A..P.T..LDTLQ.....L.DVTDFATNI..WL..QMEDLGV.AP..AV.....QP..T...Q..G..T......MP.T.FTSA....FQRRAGGVLVASQLQRFLGLAYRGLR..................................................
H9H288_MELGA/51-182                  ........................................t-RKIRGDVAVLQRV.......VC..DTFQLCT.EE....ELQLVQPD..P..PLLQAP.LDQCHKRGFQA..EMCFGQIRAGLHAYQDSLGAVLQLLPEH..T..A.L..VETLQ.....L.DAANLSTNI..QQ..QMEDLGL.DT..VT.....LP..A...EhrS..P......PP.T.FSTD....FQQQVGG-------------------..................................................
A0A2K6GYC7_PROCO/46-194              .........................................VRKIQSDSAALQEK.......LC..ATYKLCH.PE....ELVLLGHF..L..GIPRTP.LSGCPSQTLQL..AGCLSQLHSGLFLYHGLLQALAGISPEL..A..P.T..VDMLQ.....L.DVADFATTI..WQ..QMEDLGV.AP..AL.....QP..T...Q..G..T......MP.T.FTSA....FQRRAGGVLVISHLQSFLKLAYRVLR..................................................
A0A1S3GWK7_DIPOR/66-165              .......................................al--------------.......--..-------.--....--------..-..------.-----------..EGCLSQLHSGLVLYQSLLQALAGISAEV..S..P.A..LDMLQ.....L.DVTNFAITI..WQ..QMEDLGV.AP..EV.....KP..I...Q..G..T......MP.A.FTSA....FQRRAGGVLVISNLQNFLELAYRVLR..................................................
K7FXS9_PELSI/136-195                 ...................................apclpl--------------.......--..-------.--....--------..-..------.-----------..----------------------------..-..-.-..-----.....-.---------..-L..QMEDLGL.NT..VT.....YP..VaegQ..G..P......LP.S.FSSD....FEKQASGFIILANFQRFLEMALRALR..................................................
G5BRY2_HETGA/52-200                  ........................................a-RRVQAEAVEMQQK.......LC..ATYRLCH.PE....ELTLLGHS..L..SIPWVP.LKGCSSQDLQP..TRCLRQLQAGLVLYRGLLRALVGISPEL..S..P.T..VDTLQ.....L.DVADFATTI..WQ..QMEDLGT.AP..AV.....QP..T...P..G..T......ML.T.FTSA....FQRQAVGAMVASQLQCFLELAYRALR..................................................
A0A2I2Y806_GORGO/64-166              .....................................klvs--------------.......--..-------.--....--------..-..------.----------E..AGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DVTNFATTI..WQ..QMEELGM.AP..AL.....QP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASHLQSFLEVSYRVLR..................................................
H2NU88_PONAB/51-202                  .........................................VRKIQGDGAALQEKl....vsEC..ATYKLCH.PE....ELVLLGHS..L..GIPWAP.LSSCPSQALQL..TGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DVADFATTI..WQ..QMEELGM.AP..AL.....QP..T...Q..G..A......MP.A.FASA....FQRRAGGILVASHLQSFLELAYRVLR..................................................
A0A337SB92_FELCA/60-159              ........................................r--------------.......--..-------.--....--------..-..------.----------L..TGCLRQLHSGLFLYQGLLQALAGISPEL..A..P.T..LDMLQ.....L.DITDFAINI..WQ..QMEDVGM.AP..AV.....PP..T...Q..G..T......MP.T.FTSA....FQRRAGGTLVASNLQSFLEVAYRALR..................................................
A0A2I3GCQ2_NOMLE/51-202              .........................................VRKIQGDGAALQEKl....vsEC..ATYKLCH.PE....ELVLLGHS..L..GIPWAP.LSSCSSQALQL..TGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DVADFATTI..WQ..QMEELGM.AP..AL.....QP..T...Q..G..A......MP.A.FASA....FQRRAGGVLVASHLQSFLELVYRVLR..................................................
F6X4E9_XENTR/41-178                  ........................................s-RKITRDAEKLKNL.......MC..DNHGLCE.KS....ELTLIQEH..L..QLPDVP.LGQCQAGSFSQ..EGCFSQLSNGLQELQRRVVAMPGHLPEA..-..-.D..LQRLE.....K.DISDLLVNI..QE..EMEAQGI.TA..QS.....SP..S...Q..-..A......LP.T.YSKG....FHKKVAMFLILSDLAS----------tm................................................
A0A1S3GZ92_DIPOR/66-168              ....................................alvse--------------.......--..-------.--....--------..-..------.-----------..EGCLSQLHSGLVLYQSLLQALAGISAEV..S..P.A..LDMLQ.....L.DVTNFAITI..WQ..QMEDLGV.AP..EV.....KP..I...Q..G..T......MP.A.FTSA....FQRRAGGVLVISNLQNFLELAYRVLR..................................................
A0A0D9S358_CHLSB/51-202              .........................................VRKIQGDGAALQEKl....vsEC..ATYKLCH.PE....ELVLLRHS..L..GIPWAP.LSSCPSQALQL..TGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DVADFATTI..WQ..QMEDLGM.AP..AL.....QP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASHLQRFLELAYRVLR..................................................
CSF3_CANLF/22-170                    .........................................MRKVQADGTALQET.......LC..ATHQLCH.PE....ELVLLGHA..L..GIPQPP.LSSCSSQALQL..MGCLRQLHSGLFLYQGLLQALAGISPEL..A..P.T..LDTLQ.....L.DTTDFAINI..WQ..QMEDLGM.AP..AV.....PP..T...Q..G..T......MP.A.FTSA....FQRRAGGVLVASNLQSFLELAYRALR..................................................
#=GR CSF3_CANLF/22-170         SS    .........................................HHHHHHHHHHHHHH.......HH..HHHS---.GG....GTHHHHHH..H..T-----.-GGGSTTC--H..HHHHHHHHHHHHHHHHHHHHTTTSSTTT..H..H.H..HHHHH.....H.HHHHHHHHH..HH..HHHHTT-.S-..--.....--..-...-..-..-......--.-.--SH....HHHHHHHHHHHHHHHHHHHHHHHHHH..................................................
A0A402E872_9SAUR/39-138              ......................................vlr---IKEDATRTRKL.......MR..KEFKLGN.DD....ELMLMQEL..L..GISQVD.LSLCRTDPCDM..AGCFNQIRTGLHTYHGYFSHIKEILPSF..T..S.H..IESLQ.....V.DISNLSSNL..QQ..Q------.--..--.....--..-...-..-..-......--.-.----....--------------------------..................................................
G3T268_LOXAF/51-199                  .........................................VRKIRADGAVLQER.......LC..ATYKLCH.PE....ELVLLGHS..L..GITQAP.LSSCSSQALEV..VDCLHQLHSGLVLYQGLLQALAGTSPEV..A..S.T..LDLLH.....L.DVADFAINI..WQ..QMEDMGV.AP..TG.....KP..T...Q..G..P......MP.T.FTSA....FQRRAGGVLVASNLQSFLEQAYRVLR..................................................
K7FXS9_PELSI/42-116                  .........................................IRKIKGDVARLQEL.......MC..STFQLCS.ED....ELLLVKQK..L..GITQAP.LDQCHSKTFQV..SGCPRS----------------------..-..-.-..-----.....-.---------..--..-------.--..--.....--..-...-..-..-......--.-.----....--------------------------vrasteawgalglreatc................................
F1PZP1_CANLF/51-199                  .........................................MRKVQADGTALQET.......LC..ATHQLCH.PE....ELVLLGHA..L..GIPQPP.LSSCSSQALQL..MGCLRQLHSGLFLYQGLLQALAGISPEL..A..P.T..LDTLQ.....L.DTTDFAINI..WQ..QMEDLGM.AP..AV.....PP..T...Q..G..T......MP.A.FTSA....FQRRAGGVLVASNLQSFLELAYRALR..................................................
F6T8Z5_HORSE/42-190                  .........................................VRKIQADGAALQDR.......LC..ATHKLCH.PQ....ELMLLGHS..L..GIPQPL.LSSCSSQALQL..TGCLSQLHSGLLLYQGLLQALAGISPEL..A..P.T..LDMLQ.....L.DVTDFATNI..WQ..QMEDLGV.AP..VV.....QP..T...H..G..P......MP.T.FASA....FQRRAGGVLVASNLQRFLELAYRGLR..................................................
G1LTB3_AILME/51-199                  .........................................MRKVQADGTALQER.......LC..ATYKLCH.PE....ELVLLGHA..L..GIPQPP.LSSCSLKSLWT..TGCLRQLHGGLFLYQGLLQALAGVSPEL..A..P.A..LDTLQ.....L.DISDFAVNI..WQ..QMEELGV.AP..AV.....PP..T...Q..G..T......MP.T.FTSA....FQRRAGGVLVASDLQSFLELAYRALR..................................................
P97712_RAT/48-196                    .........................................VRKIQARNTELLEQ.......LC..ATYKLCH.PE....ELVLFGHS..L..GIPKAS.LSSCSSQALQQ..TKCLSQLHSGLFLYQGLLQALAGISSEL..A..P.T..LDMLH.....L.DVDNFATTI..WQ..QMESLGV.AP..TV.....QP..T...Q..S..T......MP.I.FTSA....FQRRAGGVLVTSYLQSFLETAHHALH..................................................
A0A3P8ZXD8_ESOLU/45-202              .......sqnlikkvleaipgthkscihsetlilnsttenr--------------.......--..-------.--....KLQYMATN..L..GIPSAP.TLKALAEDFTL..ETCLRHMSEGLQLHQDLLKAV---QPRL..S..N.TenLTALM.....T.DIRDLGIQI..NK..MLRAVQA.EV..TL.....QP..T...V..T..S......LA.SrLTGD....YQVQVAAHLTLVQLQSFGQDIVRSL-r.................................................
A0A091FKF3_9AVES/19-164              dgaplaelsgdqdfqlflhknleftrkikgdvaalqrvvvs--------------.......--..-------.--....--------..-..------.------PGCRA..GACFSQIRDGLRNYHSSLATVLELLPTH..A..G.L..VETLQ.....L.DAANLSSNI..QQ..QMEDLGL.AT..VT.....FP..T...EdrS..P......LP.V.FSSR....FQHQVGGFFILANFQRFLETAYRALR..................................................
A0A2K5MBQ3_CERAT/51-199              .........................................VRKIQGDGAALQEK.......LC..ATYKLCH.PE....ELVLLRHS..L..GIPWAP.LSSCPSQALQL..TGCLSQLHSGLFLYQGLLQALEGISPEL..G..P.T..LDTLQ.....L.DVADFATTI..WQ..QMEDLGM.AP..AL.....QP..T...Q..G..A......MP.A.FTSA....FQRRAGGVLVASHLQRFLELAYRVLR..................................................
A0A2K5CMX9_AOTNA/65-166              ......................................lvs--------------.......--..-------.--....--------..-..------.----------E..TGCLRQLHSGLFLYQGLLQTLEGISPEL..A..P.T..LDMLR.....L.DIADFATTI..WQ..QMEELGT.AP..AL.....QP..T...R..S..A......TP.A.LPSA....FQRRVGGLLVASHLQSFLELVHRVLR..................................................
A0A2K6T182_SAIBB/51-202              ........................................a-RKVQGDGTELQEKl....vsEC..ATYKMCH.LE....EMVLFRHS..L..GIPQVS.LSSCSSQALQL..TGCLRQLHSGLFLYQGLLQTLEGISPEL..A..P.T..LDMLR.....L.DIADFATTI..WQ..QMEELGT.AP..AL.....QP..T...R..G..A......TP.A.LPSA....FQRRVGGLLVASHLQSFLELVHRVLR..................................................
A0A3Q2CHK1_CYPVA/36-183              ........................esvedthkscvhlqslq--------------.......--..--WKVPE.NA....KLATMRST..I..GIPSAP.VIKPISANFSL..ETALRAMHDGLELHHGLLRS---ISPRLevK..D.R..MNALQ.....Y.DVRDLKIEI..FR..MLKIKTT.EA..TV.....PP..T...P..T..S......VE.LhLPGD....YEVQVAAHLTLVQLQAFS--------qdvarcfr..........................................
W5N5E3_LEPOC/49-203                  .........................................VKKIQDDIPEVTKA.......LI..AEPKLNAlPDykdiDLQMMAAQ..L..GIPSAP.VLKALTTEFTL..ETSLTRMTEGLQMFQHLLTIVRDHSV--..A..PeK..LDILL.....A.DIRDLMTQN..YKvsQLAQLEI.N-..VV.....QY..V...D..S..G......LA.ArLAGE....FEKRVAAHIVLANLRAFAQDVHRSLR..................................................
#=GC SS_cons                         .........................................HHHHHHHHHHHHHHH......HH..HHHT---.GG....GCHHHHHH..H..T-----.SGGGSTTCSTH..HHHHHHHHHHHHHHHHHHHHTTTSSTTT..H..H.H..HHHHH.....H.HHHHHHHHH..HH..HHHHTT-.S-..SS.....--..S...S..S..-......-S.-.--SH....HHHHHHHHHHHHHHHHHHHHHHHHHH..................................................
#=GC seq_cons                        ..........................................RKlpu-sstLpct........C..sTapLC+.sE....ELhLltps..L..GIspss.LspC.SpshQl..sGCLsQLHuGLaLYQGLLQALtGISPEL..u..P.T..LDsLQ.....L.DluDFATsI..WQ..QMEDLGh.AP..ul.....pP..T...Q..G..s......hP.s.FoSA....FQRRAGGVLVASpLQpFLElAYRsLR..................................................
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