#=GF ID   Gag_p6
#=GF AC   PF08705.15
#=GF DE   Gag protein p6
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF SE   pdb_2c55
#=GF GA   27.00 27.00;
#=GF TC   28.00 31.80;
#=GF NC   24.20 19.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   16234236
#=GF RT   Solution structure of the human immunodeficiency virus type 1 p6
#=GF RT   protein. 
#=GF RA   Fossen T, Wray V, Bruns K, Rachmat J, Henklein P, Tessmer U,
#=GF RA   Maczurek A, Klinger P, Schubert U; 
#=GF RL   J Biol Chem. 2005;280:42515-42527.
#=GF DR   INTERPRO; IPR014817;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   HIV protein p6 contains two late-budding domains (L domains)
#=GF CC   which are short sequence motifs essential for viral particle
#=GF CC   release.  p6 interacts with the endosomal sorting complex and
#=GF CC   represents a docking site for several cellular and binding
#=GF CC   factors [1].  The PTAP motif interacts with the cellular budding
#=GF CC   factor TSG101 [1].  This domain is also found in some chimpanzee
#=GF CC   immunodeficiency virus (SIV-cpz) proteins.
#=GF SQ   20
#=GS GAG_HV1JR/449-490     AC P20873.3
#=GS Q9YX54_9HIV1/450-486  AC Q9YX54.1
#=GS W8EEZ4_9PLVG/448-485  AC W8EEZ4.1
#=GS GAG_HV1ET/458-493     AC Q75001.3
#=GS GAG_HV1EL/450-486     AC P04592.3
#=GS GAG_SIVMB/445-485     AC Q1A268.3
#=GS GAG_HV1BR/461-498     AC P03348.3
#=GS GAG_HV1RH/451-487     AC P05890.3
#=GS GAG_HV1MA/455-491     AC P04594.3
#=GS GAG_HV1H2/449-486     AC P04591.3
#=GS GAG_HV192/446-482     AC O12157.3
#=GS GAG_HV1VI/443-480     AC Q9QSR4.3
#=GS GAG_SIVEK/456-497     AC Q1A250.3
#=GS GAG_HV1B1/461-498     AC P03347.3
#=GS Q9Q6W4_9HIV1/447-484  AC Q9Q6W4.1
#=GS GAG_HV1YF/456-498     AC O91079.3
#=GS GAG_HV1U4/443-479     AC P24736.3
#=GS GAG_SIVCZ/459-495     AC P17282.1
#=GS GAG_HV193/444-481     AC O89291.3
#=GS GAG_HV1MN/452-493     AC P05888.3
GAG_HV1JR/449-490                ..LQSRPEPTAPPEESFRFGEE.TaTPSQKQEQKqepiDKE-.....LYPL....
Q9YX54_9HIV1/450-486             ..LQNRPEPTAPPAECLERKEE.T.TSSLKQEPR....DKE-.....LYPL....
W8EEZ4_9PLVG/448-485             ..LQNRPEPTAPPEESFR-EETtT.PPAQKQEPI....DKEL.....-YP-sl..
GAG_HV1ET/458-493                sl---RPEPTAPPPESFRFEEA.-.TPSPKQELK....DREA.....----ltsl
GAG_HV1EL/450-486                ..LQSRPEPTAPPAESFGFGEE.I.TPSQKQEQK....DKE-.....LYPL....
GAG_SIVMB/445-485                ..LQKRPEPTAPPIESFGFREE.-.EPAQKEEVK....SEETen.klY-P-ql..
GAG_HV1BR/461-498                ..LQSRPEPTAPPEESFRSGVE.TtTPSQKQEPI....DKE-.....LYPL....
GAG_HV1RH/451-487                ..LQSRPEPTAPPEESFRFGEE.T.TPSQKQEKI....DKE-.....LYPL....
GAG_HV1MA/455-491                ..LQSRPEPTAPPAESFGFGEE.I.KPSQKQEQK....DKE-.....LYPL....
GAG_HV1H2/449-486                ..LQSRPEPTAPPEESFRSGVE.TtTPPQKQEPI....DKE-.....LYPL....
GAG_HV192/446-482                ..LQNRTEPTAPPEESFRFGEE.TtTPSRKQETI....DKEL.....--PL....
GAG_HV1VI/443-480                ..LQSRPEPTAPPAESFGFREE.I.TPSPKQEQK....DGEL.....YPPL....
GAG_SIVEK/456-497                tt--TRKEPTAPPIESYGYQEEkT.TQGTEREEK....EKTEs..slYPPL....
GAG_HV1B1/461-498                ..LQSRPEPTAPPEESFRSGVE.TtTPPQKQEPI....DKE-.....LYPL....
Q9Q6W4_9HIV1/447-484             ..PQSRPEPSAPPAENFGMGEE.I.TPSLKQEQK....DREQ.....HPPS....
GAG_HV1YF/456-498                tt--TRKEPTAPPLESYGFQEE.K.STQGKEMQE....NQERtenslYPPL....
GAG_HV1U4/443-479                ..PQSRPEPTAPPAEIFGMGEK.M.TSPAKQELK....DREQ.....-TPL....
GAG_SIVCZ/459-495                ..VQNRTEPTAPPIESYGYQEE.-.---EKSQEK....KE-Ges.slYPP-t...
GAG_HV193/444-481                .i-QNRPEPSAPPAESFRFGEE.T.TPSPKQEQK....DEGL.....YPPL....
GAG_HV1MN/452-493                ..PQSRTEPTAPPEESFRFGEE.TtTPYQKQEKK....Q-ETid.kdLYPL....
#=GC seq_cons                    ..LQoRPEPTAPPtESFtaGEE.p.TPupKQEpK....D+E......h.PL....
//