GenomeNet

Database: Pfam
Entry: HCV_NS1
LinkDB: HCV_NS1
Original site: HCV_NS1 
#=GF ID   HCV_NS1
#=GF AC   PF01560.18
#=GF DE   Hepatitis C virus non-structural protein E2/NS1
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Swiss-Prot
#=GF GA   20.30 20.30;
#=GF TC   20.40 730.00;
#=GF NC   20.20 20.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   9224925
#=GF RT   The nonstructural proteins of the hepatitis C virus: structure
#=GF RT   and functions. 
#=GF RA   Neddermann P, Tomei L, Steinkuhler C, Gallinari P, Tramontano A,
#=GF RA   De Francesco R; 
#=GF RL   Biol Chem 1997;378:469-476.
#=GF RN   [2]
#=GF RM   9425941
#=GF RT   Comparison of the rate of sequence variation in the
#=GF RT   hypervariable region of E2/NS1 region of hepatitis C virus in
#=GF RT   normal and hypogammaglobulinemic patients. 
#=GF RA   Booth JC, Kumar U, Webster D, Monjardino J, Thomas HC; 
#=GF RL   Hepatology 1998;27:223-227.
#=GF DR   INTERPRO; IPR002531;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   The hypervariable region of the E2/NS1 region of hepatitis C
#=GF CC   virus varies greatly between viral isolates. E2 is thought to
#=GF CC   encode a structurally unconstrained envelope protein [2].
#=GF SQ   1
#=GS POLG_HCVH/386-729  AC P27958.3
#=GS POLG_HCVH/386-729  DR PDB; 4Q0X E; 434-442;
#=GS POLG_HCVH/386-729  DR PDB; 4JZO K; 436-446;
#=GS POLG_HCVH/386-729  DR PDB; 4MWF C; 421-645;
#=GS POLG_HCVH/386-729  DR PDB; 4JZO J; 436-446;
#=GS POLG_HCVH/386-729  DR PDB; 6BZV L; 413-423;
#=GS POLG_HCVH/386-729  DR PDB; 6BZU I; 413-421;
#=GS POLG_HCVH/386-729  DR PDB; 6BZW I; 413-421;
#=GS POLG_HCVH/386-729  DR PDB; 6BZW L; 413-421;
#=GS POLG_HCVH/386-729  DR PDB; 6BZV I; 413-421;
#=GS POLG_HCVH/386-729  DR PDB; 4MWF D; 421-645;
#=GS POLG_HCVH/386-729  DR PDB; 6BZY B; 412-422;
#=GS POLG_HCVH/386-729  DR PDB; 4JZN K; 435-446;
#=GS POLG_HCVH/386-729  DR PDB; 6BZW K; 413-421;
#=GS POLG_HCVH/386-729  DR PDB; 6BZW J; 413-422;
#=GS POLG_HCVH/386-729  DR PDB; 4Z0X C; 435-446;
#=GS POLG_HCVH/386-729  DR PDB; 6BZU K; 412-422;
#=GS POLG_HCVH/386-729  DR PDB; 4JZO L; 436-446;
#=GS POLG_HCVH/386-729  DR PDB; 6BZU L; 412-423;
#=GS POLG_HCVH/386-729  DR PDB; 5ERW C; 438-446;
#=GS POLG_HCVH/386-729  DR PDB; 6BZU J; 412-421;
#=GS POLG_HCVH/386-729  DR PDB; 4JZO I; 436-446;
#=GS POLG_HCVH/386-729  DR PDB; 5EOC Q; 412-422;
#=GS POLG_HCVH/386-729  DR PDB; 6BZV J; 413-422;
#=GS POLG_HCVH/386-729  DR PDB; 4XVJ A; 412-423;
#=GS POLG_HCVH/386-729  DR PDB; 5EOC P; 412-422;
#=GS POLG_HCVH/386-729  DR PDB; 6BZV K; 413-422;
#=GS POLG_HCVH/386-729  DR PDB; 5FGC A; 415-423;
POLG_HCVH/386-729             HVTGGNAGRTTAGLVGLLTPGAKQNIQLINTNGSWHINSTALNCNESLNTGWLAGLFYQHKFNSSGCPERLASCRRLTDFAQGWGPISYANGSGLDERPYCWHYPPRPCGIVPAKSVCGPVYCFTPSPVVVGTTDRSGAPTYSWGANDTDVFVLNNTRPPLGNWFGCTWMNSTGFTKVCGAPPCVIGGVGNNTLLCPTDCFRKYPEATYSRCGSGPRITPRCMVDYPYRLWHYPCTINYTIFKVRMYVGGVEHRLEAACNWTRGERCDLEDRDRSELSPLLLSTTQWQVLPCSFTTLPALSTGLIHLHQNIVDVQYLYGVGSSIASWAIKWEYVVLLFLLLADA
#=GR POLG_HCVH/386-729  SS    XXXXXXXXXXXXXXXXXXXXXXXXXXEEEEETTEEEECCSEEXBXXTTTTHGGGGGTSXXXXXTTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEEEGGGBEEXXEEESSSEEEXXXBXTTSXBXXSTTXSTTXEEEXXXXXSTTSSXSEEEEEBTTSXEEEEEXXGGGGSXTTTTXSSSXSXXXXXXXXXXXXXXXSSXECCTTEEEXXTTHHHHXGGGCCXEEEEEEEEETTEEEEEEEEEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
#=GC SS_cons                  XXXXXXXXXXXXXXXXXXXXXXXXXXEEEEETTEEEECCSEEXBXXTTTTHGGGGGTSXXXXXTTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEEEGGGBEEXXEEESSSEEEXXXBXTTSXBXXSTTXSTTXEEEXXXXXSTTSSXSEEEEEBTTSXEEEEEXXGGGGSXTTTTXSSSXSXXXXXXXXXXXXXXXSSXECCTTEEEXXTTHHHHXGGGCCXEEEEEEEEETTEEEEEEEEEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
#=GC seq_cons                 HVTGGNAGRTTAGLVGLLTPGAKQNIQLINTNGSWHINSTALNCNESLNTGWLAGLFYQHKFNSSGCPERLASCRRLTDFAQGWGPISYANGSGLDERPYCWHYPPRPCGIVPAKSVCGPVYCFTPSPVVVGTTDRSGAPTYSWGANDTDVFVLNNTRPPLGNWFGCTWMNSTGFTKVCGAPPCVIGGVGNNTLLCPTDCFRKYPEATYSRCGSGPRITPRCMVDYPYRLWHYPCTINYTIFKVRMYVGGVEHRLEAACNWTRGERCDLEDRDRSELSPLLLSTTQWQVLPCSFTTLPALSTGLIHLHQNIVDVQYLYGVGSSIASWAIKWEYVVLLFLLLADA
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