GenomeNet

Database: Pfam
Entry: HCV_NS5a_1b
LinkDB: HCV_NS5a_1b
Original site: HCV_NS5a_1b 
#=GF ID   HCV_NS5a_1b
#=GF AC   PF08301.13
#=GF DE   Hepatitis C virus non-structural 5a domain 1b
#=GF AU   Paterson M;
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Bateman A
#=GF GA   21.30 21.30;
#=GF TC   21.30 112.30;
#=GF NC   21.20 21.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   9710605
#=GF RT   Control of PKR protein kinase by hepatitis C virus nonstructural
#=GF RT   5A protein: molecular mechanisms of kinase regulation. 
#=GF RA   Gale M Jr, Blakely CM, Kwieciszewski B, Tan SL, Dossett M, Tang
#=GF RA   NM, Korth MJ, Polyak SJ, Gretch DR, Katze MG; 
#=GF RL   Mol Cell Biol 1998;18:5208-5218.
#=GF RN   [2]
#=GF RM   9143277
#=GF RT   Evidence that hepatitis C virus resistance to interferon is
#=GF RT   mediated through repression of the PKR protein kinase by the
#=GF RT   nonstructural 5A protein. 
#=GF RA   Gale MJ Jr, Korth MJ, Tang NM, Tan SL, Hopkins DA, Dever TE,
#=GF RA   Polyak SJ, Gretch DR, Katze MG; 
#=GF RL   Virology 1997;230:217-227.
#=GF RN   [3]
#=GF RM   15902263
#=GF RT   Structure of the zinc-binding domain of an essential component
#=GF RT   of the hepatitis C virus replicase. 
#=GF RA   Tellinghuisen TL, Marcotrigiano J, Rice CM; 
#=GF RL   Nature 2005;435:374-379.
#=GF DR   INTERPRO; IPR013193;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   The molecular function of the non-structural 5a protein is
#=GF CC   uncertain.  The NS5a protein is phosphorylated when expressed in
#=GF CC   mammalian cells.  It is thought to interact with the ds RNA
#=GF CC   dependent (interferon inducible) kinase PKR, Swiss:P19525 [1,2].
#=GF CC   This region corresponds to the 1b domain [3].
#=GF SQ   2
#=GS POLG_HCVH/2068-2168     AC P27958.3
#=GS O41892_PEGIA/2037-2135  AC O41892.1
POLG_HCVH/2068-2168                GPCTPLPAPNYKFALWRVSAEEYVEIRRVGDFHYVSGMTTDNLkCPCQIPSPEFF--TELDGVRLHRFAPPCKPLLREEVSFRVGLHEYPVGSQLPCEPEPDV.
O41892_PEGIA/2037-2135             GGATPVVPP-RGPKTYQLGCADWIEALVVSGTVTVTASSAYDL.TAAEVRRAVKASPCFAGDLPVSWEAPICRPAMVYRGGQTIQLDG--VRRTLPCGLPLG-a
#=GC seq_cons                      GssTPlssP.ht.thaplust-alEhhhVushhhVou.os.sL.ssspl.ps.hh..s.hssl.lph.AP.C+Phhh.csu.pltLct..VtppLPCt...s..
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