GenomeNet

Database: Pfam
Entry: HCV_core
LinkDB: HCV_core
Original site: HCV_core 
#=GF ID   HCV_core
#=GF AC   PF01542.18
#=GF DE   Hepatitis C virus core protein
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Swiss-Prot
#=GF GA   21.60 21.60;
#=GF TC   22.50 32.50;
#=GF NC   21.40 20.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10329544
#=GF RT   Hepatitis C virus core protein interacts with a human DEAD box
#=GF RT   protein DDX3. 
#=GF RA   Owsianka AM, Patel AH; 
#=GF RL   Virology 1999;257:330-340.
#=GF RN   [2]
#=GF RM   10082392
#=GF RT   Functional analysis of a transrepressor domain in the hepatitis
#=GF RT   C virus core protein. 
#=GF RA   Ray RB, Ghosh AK, Meyer K, Ray R; 
#=GF RL   Virus Res 1999;59:211-217.
#=GF DR   INTERPRO; IPR002521;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   The viral core protein forms the internal viral coat that
#=GF CC   encapsidates the genomic RNA and is enveloped in a host
#=GF CC   cell-derived lipid membrane. The core protein has been shown, by
#=GF CC   yeast two-hybrid assay to interact with cellular DEAD box
#=GF CC   helicases [1]. The N terminus of the core protein is involved in
#=GF CC   transcriptional repression [2].
#=GF SQ   2
#=GS A0A0P0QKS2_9VIRU/229-299  AC A0A0P0QKS2.1
#=GS POLG_HCVH/116-190         AC P27958.3
A0A0P0QKS2_9VIRU/229-299             SRNLGRVIDGVTGWAADLGMSLPIVWPVTGYGLRFLAHCVRGLEDVLNAGTG-VAGVQLFIIMLCLL--------pvpmd
POLG_HCVH/116-190                    SRNLGKVIDTLTCGFADLMGYIPLVGAPLGGAARALAHGVRVLEDGVNYATGNLPGCSFSIFLLALLSCLTVPAS.....
#=GC seq_cons                        SRNLG+VIDslTshhADLhh.lPlVhsshGhuhRhLAHsVRsLEDslNhuTG.lsGsph.IhhLsLL.............
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