GenomeNet

Database: Pfam
Entry: HNF-1A_C
LinkDB: HNF-1A_C
Original site: HNF-1A_C 
#=GF ID   HNF-1A_C
#=GF AC   PF04813.13
#=GF DE   Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus
#=GF AU   Kerrison ND;0000-0002-1471-953X
#=GF SE   Pfam-B_2624 (release 7.6)
#=GF GA   27.30 27.30;
#=GF TC   27.70 27.70;
#=GF NC   25.80 25.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   7900999
#=GF RT   More potent transcriptional activators or a transdominant
#=GF RT   inhibitor of the HNF1 homeoprotein family are generated by
#=GF RT   alternative RNA processing. 
#=GF RA   Bach I, Yaniv M; 
#=GF RL   EMBO J 1993;12:4229-4242.
#=GF RN   [2]
#=GF RM   9133564
#=GF RT   A prevalent amino acid polymorphism at codon 98 in the
#=GF RT   hepatocyte nuclear factor-1alpha gene is associated with reduced
#=GF RT   serum C-peptide and insulin responses to an oral glucose
#=GF RT   challenge. 
#=GF RA   Urhammer SA, Fridberg M, Hansen T, Rasmussen SK, Moller AM,
#=GF RA   Clausen JO, Pedersen O; 
#=GF RL   Diabetes 1997;46:912-916.
#=GF DR   INTERPRO; IPR006898;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of an alternative C terminus of
#=GF CC   homeobox-containing transcription factor HNF-1, found in the
#=GF CC   HNF-1A isoform.  Different isoforms of HNF-1 are generated by
#=GF CC   the differential use of polyadenylation sites and by alternative
#=GF CC   splicing.                      The C-terminal region of HNF-1 is
#=GF CC   responsible for the activation of transcription, and HNF-1A,
#=GF CC   which has this C-terminal extension, transactivates less well
#=GF CC   than the B and C isoforms [1]. Mutations and polymorphisms in
#=GF CC   HNF-1 cause the type 3 form of maturity-onset diabetes of the
#=GF CC   young (MODY3) [2].
#=GF SQ   196
#=GS A0A226P131_COLVI/546-633  AC A0A226P131.1
#=GS A0A3B5AJJ9_9TELE/490-559  AC A0A3B5AJJ9.1
#=GS A0A1S3WEG7_ERIEU/540-627  AC A0A1S3WEG7.1
#=GS E0YMJ1_HUMAN/138-226      AC E0YMJ1.1
#=GS A0A2Y9EP35_PHYMC/543-631  AC A0A2Y9EP35.1
#=GS G7N601_MACMU/542-630      AC G7N601.1
#=GS A0A2K6KTK9_RHIBE/365-453  AC A0A2K6KTK9.1
#=GS A0A3Q7UW39_VULVU/542-630  AC A0A3Q7UW39.1
#=GS HNF1A_MOUSE/540-627       AC P22361.2
#=GS A0A384DFU3_URSMA/586-674  AC A0A384DFU3.1
#=GS A0A2K6CWL8_MACNE/573-661  AC A0A2K6CWL8.1
#=GS A0A3Q1IZ85_ANATE/490-559  AC A0A3Q1IZ85.1
#=GS A0A2K6KT95_RHIBE/542-630  AC A0A2K6KT95.1
#=GS G1PCX9_MYOLU/539-627      AC G1PCX9.1
#=GS A0A3Q1B664_AMPOC/493-562  AC A0A3Q1B664.1
#=GS A0A1L8I0A9_XENLA/509-593  AC A0A1L8I0A9.1
#=GS A0A2K6SK79_SAIBB/542-630  AC A0A2K6SK79.1
#=GS B7ZRG9_XENLA/420-499      AC B7ZRG9.1
#=GS A0A340WMF4_LIPVE/543-631  AC A0A340WMF4.1
#=GS L9KRL7_TUPCH/542-630      AC L9KRL7.1
#=GS A0A2R8MMA5_CALJA/568-656  AC A0A2R8MMA5.1
#=GS A0A3B3Z7W1_9GOBI/489-558  AC A0A3B3Z7W1.1
#=GS A0A2K5NW02_CERAT/573-661  AC A0A2K5NW02.1
#=GS A0A4D9DWM2_9SAUR/546-633  AC A0A4D9DWM2.1
#=GS A0A402EDU5_9SAUR/557-643  AC A0A402EDU5.1
#=GS A0A2I3G3A5_NOMLE/324-412  AC A0A2I3G3A5.1
#=GS A0A3Q3WWC6_MOLML/459-528  AC A0A3Q3WWC6.1
#=GS H0WZU1_OTOGA/542-630      AC H0WZU1.1
#=GS K7G2U5_PELSI/545-632      AC K7G2U5.1
#=GS A0A218V2Q6_9PASE/546-633  AC A0A218V2Q6.1
#=GS H0V9M5_CAVPO/539-627      AC H0V9M5.1
#=GS A0A3Q1GUD8_9TELE/508-577  AC A0A3Q1GUD8.1
#=GS HNF1A_HUMAN/542-630       AC P20823.2
#=GS A0A1D5R0W9_MACMU/573-661  AC A0A1D5R0W9.1
#=GS A0A401P8V3_SCYTO/163-247  AC A0A401P8V3.1
#=GS A0A3Q2H035_HORSE/365-453  AC A0A3Q2H035.1
#=GS A0A2K6GAP9_PROCO/543-631  AC A0A2K6GAP9.1
#=GS A0A3B3CDH6_ORYME/490-559  AC A0A3B3CDH6.1
#=GS A0A2Y9SHL3_PHYMC/554-642  AC A0A2Y9SHL3.1
#=GS A0A1A6HQR7_NEOLE/311-354  AC A0A1A6HQR7.1
#=GS A0A1S2ZVP4_ERIEU/533-620  AC A0A1S2ZVP4.1
#=GS G3WPM8_SARHA/544-636      AC G3WPM8.1
#=GS A0A2U3VNN1_ODORO/542-630  AC A0A2U3VNN1.1
#=GS H3C3K4_TETNG/522-596      AC H3C3K4.1
#=GS H0ZHD2_TAEGU/545-632      AC H0ZHD2.1
#=GS A0A2Y9DQ97_TRIMA/542-630  AC A0A2Y9DQ97.1
#=GS A0A0D9S4M1_CHLSB/542-631  AC A0A0D9S4M1.1
#=GS G1S1E9_NOMLE/449-537      AC G1S1E9.2
#=GS A0A3Q4M2M0_NEOBR/489-558  AC A0A3Q4M2M0.1
#=GS HNF1A_CHICK/546-633       AC Q90867.1
#=GS G3QNW9_GORGO/542-630      AC G3QNW9.1
#=GS A0A2K6KTB1_RHIBE/573-661  AC A0A2K6KTB1.1
#=GS A0A2K6CWL6_MACNE/542-630  AC A0A2K6CWL6.1
#=GS W5PWE7_SHEEP/567-653      AC W5PWE7.1
#=GS A0A2I2Y531_GORGO/365-453  AC A0A2I2Y531.1
#=GS F1PJ35_CANLF/542-630      AC F1PJ35.1
#=GS W5KDZ5_ASTMX/521-567      AC W5KDZ5.2
#=GS A0A3B3X773_9TELE/492-561  AC A0A3B3X773.1
#=GS A0A2K6NLD8_RHIRO/365-453  AC A0A2K6NLD8.1
#=GS A0A2U9BT26_SCOMX/484-553  AC A0A2U9BT26.1
#=GS A0A2K5J3N0_COLAP/573-661  AC A0A2K5J3N0.1
#=GS A0A384A9N0_BALAS/539-627  AC A0A384A9N0.1
#=GS F2Z4S1_DANRE/489-559      AC F2Z4S1.1
#=GS A0A1D5QUU5_MACMU/373-445  AC A0A1D5QUU5.1
#=GS A0A2Y9LA27_DELLE/543-631  AC A0A2Y9LA27.1
#=GS A0A3P8Z6V0_ESOLU/488-557  AC A0A3P8Z6V0.1
#=GS E0YMI9_HUMAN/363-451      AC E0YMI9.1
#=GS F6Q5D3_MONDO/541-572      AC F6Q5D3.2
#=GS A0A384A9M2_BALAS/543-631  AC A0A384A9M2.1
#=GS U3JYI0_FICAL/548-635      AC U3JYI0.1
#=GS H2MXK2_ORYLA/490-558      AC H2MXK2.2
#=GS A0A096MVZ6_PAPAN/549-637  AC A0A096MVZ6.2
#=GS A0A3P8VSE4_CYNSE/478-547  AC A0A3P8VSE4.1
#=GS A0A2K5TN37_MACFA/510-598  AC A0A2K5TN37.1
#=GS A0A087Y4Z6_POEFO/492-561  AC A0A087Y4Z6.1
#=GS F1MD26_BOVIN/544-632      AC F1MD26.1
#=GS A0A3B4F234_9CICH/489-558  AC A0A3B4F234.1
#=GS A0A2U4CJZ3_TURTR/571-659  AC A0A2U4CJZ3.1
#=GS H9KX05_CALJA/549-637      AC H9KX05.2
#=GS A0A2K5J3U0_COLAP/365-453  AC A0A2K5J3U0.1
#=GS A0A452IJ85_9SAUR/363-450  AC A0A452IJ85.1
#=GS A0A2I3MWC9_PAPAN/573-661  AC A0A2I3MWC9.1
#=GS A0A2Y9KI17_ENHLU/542-630  AC A0A2Y9KI17.1
#=GS M3XW08_MUSPF/544-632      AC M3XW08.1
#=GS A0A2K5NWJ9_CERAT/542-630  AC A0A2K5NWJ9.1
#=GS A0A2K6GAL3_PROCO/573-661  AC A0A2K6GAL3.1
#=GS A0A1U7TI53_TARSY/138-226  AC A0A1U7TI53.1
#=GS R0L7K0_ANAPL/546-633      AC R0L7K0.1
#=GS A0A3B4Y0T5_SERLL/509-578  AC A0A3B4Y0T5.1
#=GS A0A2R8ZHP9_PANPA/549-637  AC A0A2R8ZHP9.1
#=GS A0A401SHS4_CHIPU/572-656  AC A0A401SHS4.1
#=GS A0A3B3QQC7_9TELE/482-555  AC A0A3B3QQC7.1
#=GS A0A2K5RXZ0_CEBCA/364-452  AC A0A2K5RXZ0.1
#=GS A0A3Q0D4W2_MESAU/548-636  AC A0A3Q0D4W2.1
#=GS A0A3Q3AFP1_KRYMA/490-559  AC A0A3Q3AFP1.1
#=GS A0A1V4JRS9_PATFA/543-630  AC A0A1V4JRS9.1
#=GS A0A2K5ZT55_MANLE/573-661  AC A0A2K5ZT55.1
#=GS A0A1S3WE68_ERIEU/539-626  AC A0A1S3WE68.1
#=GS A0A1U7QQX3_MESAU/541-629  AC A0A1U7QQX3.1
#=GS G3TJQ6_LOXAF/542-630      AC G3TJQ6.1
#=GS F7CR09_HORSE/559-647      AC F7CR09.2
#=GS A0A2I3M205_PAPAN/365-453  AC A0A2I3M205.1
#=GS A0A452SA16_URSAM/542-630  AC A0A452SA16.1
#=GS A0A1L8HQ75_XENLA/525-604  AC A0A1L8HQ75.1
#=GS A0A2U3ZC55_ODORO/549-637  AC A0A2U3ZC55.1
#=GS A0A2I3T729_PANTR/573-661  AC A0A2I3T729.1
#=GS A0A2K5ZT33_MANLE/542-630  AC A0A2K5ZT33.1
#=GS M3XHE8_LATCH/545-595      AC M3XHE8.1
#=GS A0A2Y9DQC9_TRIMA/549-637  AC A0A2Y9DQC9.1
#=GS A0A3Q7TPJ5_VULVU/572-660  AC A0A3Q7TPJ5.1
#=GS A0A226NBL9_CALSU/546-633  AC A0A226NBL9.1
#=GS H3BXN4_TETNG/521-590      AC H3BXN4.1
#=GS M7C177_CHEMY/526-613      AC M7C177.1
#=GS M3WBT5_FELCA/561-649      AC M3WBT5.2
#=GS A0A3Q3LS37_9LABR/507-554  AC A0A3Q3LS37.1
#=GS A0A2K5NWR4_CERAT/365-453  AC A0A2K5NWR4.1
#=GS A0A2K6GAM0_PROCO/366-454  AC A0A2K6GAM0.1
#=GS A0A2K5J3P3_COLAP/542-630  AC A0A2K5J3P3.1
#=GS F6Q5D3_MONDO/571-612      AC F6Q5D3.2
#=GS U3I461_ANAPP/546-633      AC U3I461.1
#=GS H2Q721_PANTR/549-637      AC H2Q721.2
#=GS A0A3B3UEF3_9TELE/492-561  AC A0A3B3UEF3.1
#=GS A0A2R8MBN5_CALJA/364-452  AC A0A2R8MBN5.1
#=GS A0A2U3Y2C6_LEPWE/542-630  AC A0A2U3Y2C6.1
#=GS A0A2K5C9H9_AOTNA/547-635  AC A0A2K5C9H9.1
#=GS A0A2I4CK97_9TELE/491-560  AC A0A2I4CK97.1
#=GS A0A3M0JYB0_HIRRU/546-633  AC A0A3M0JYB0.1
#=GS A0A3Q2VGG5_HAPBU/489-558  AC A0A3Q2VGG5.1
#=GS A0A2K6CWT9_MACNE/365-453  AC A0A2K6CWT9.1
#=GS A0A2Y9KVP7_ENHLU/549-637  AC A0A2Y9KVP7.1
#=GS A0A3Q7X8Z5_URSAR/571-659  AC A0A3Q7X8Z5.1
#=GS A0A2K5TN46_MACFA/350-438  AC A0A2K5TN46.1
#=GS A0A1L1RPG1_CHICK/546-633  AC A0A1L1RPG1.1
#=GS A0A3Q7T3X7_VULVU/542-591  AC A0A3Q7T3X7.1
#=GS A0A2I2ZCZ2_GORGO/573-661  AC A0A2I2ZCZ2.1
#=GS A0A1S3F1B9_DIPOR/542-630  AC A0A1S3F1B9.1
#=GS A0A3P9ASB7_9CICH/489-558  AC A0A3P9ASB7.1
#=GS A0A1D5QAI7_MACMU/582-670  AC A0A1D5QAI7.1
#=GS A0A3P8N5V0_ASTCA/489-558  AC A0A3P8N5V0.1
#=GS A0A2R8ZKU2_PANPA/573-661  AC A0A2R8ZKU2.1
#=GS A0A2K5ZT62_MANLE/365-453  AC A0A2K5ZT62.1
#=GS A0A3Q0DPP0_TARSY/145-233  AC A0A3Q0DPP0.1
#=GS A0A2D0QVD0_ICTPU/506-575  AC A0A2D0QVD0.1
#=GS A0A2I3TKC6_PANTR/365-453  AC A0A2I3TKC6.1
#=GS A0A452IJB6_9SAUR/546-633  AC A0A452IJB6.1
#=GS A0A3P8VF60_CYNSE/139-191  AC A0A3P8VF60.1
#=GS A0A0A0MTK8_HUMAN/573-661  AC A0A0A0MTK8.1
#=GS A0A3B5AGK0_9TELE/485-554  AC A0A3B5AGK0.1
#=GS A0A0Q3U1U1_AMAAE/543-630  AC A0A0Q3U1U1.1
#=GS A0A2I3HRE5_NOMLE/473-561  AC A0A2I3HRE5.1
#=GS A0A2K6NLC5_RHIRO/542-630  AC A0A2K6NLC5.1
#=GS A0A091CZU1_FUKDA/542-630  AC A0A091CZU1.1
#=GS A0A3Q2E0K2_CYPVA/489-558  AC A0A3Q2E0K2.1
#=GS A0A3Q3KPB0_9TELE/508-577  AC A0A3Q3KPB0.1
#=GS G3PGQ4_GASAC/494-563      AC G3PGQ4.1
#=GS Q4PJJ8_PIG/542-630        AC Q4PJJ8.1
#=GS A0A3B3Z7Q6_9GOBI/487-556  AC A0A3B3Z7Q6.1
#=GS A0A3Q7Y2Q5_URSAR/586-674  AC A0A3Q7Y2Q5.1
#=GS A0A2D0QXA6_ICTPU/510-579  AC A0A2D0QXA6.1
#=GS G5AWX7_HETGA/542-630      AC G5AWX7.1
#=GS A0A3P8SCV4_AMPPE/493-562  AC A0A3P8SCV4.1
#=GS A0A3Q7WCN0_URSAR/586-687  AC A0A3Q7WCN0.1
#=GS A0A3B4T694_SERDU/492-561  AC A0A3B4T694.1
#=GS L5KWI4_PTEAL/380-468      AC L5KWI4.1
#=GS A0A3Q0D5U9_MESAU/451-539  AC A0A3Q0D5U9.1
#=GS A0A2I0LZ40_COLLI/543-630  AC A0A2I0LZ40.1
#=GS A0A2K5C9I1_AOTNA/364-452  AC A0A2K5C9I1.1
#=GS H2UWZ0_TAKRU/468-536      AC H2UWZ0.2
#=GS A0A2K6SKA7_SAIBB/364-452  AC A0A2K6SKA7.1
#=GS A0A2R8ZNZ9_PANPA/365-453  AC A0A2R8ZNZ9.1
#=GS A0A2K5RXT3_CEBCA/572-660  AC A0A2K5RXT3.1
#=GS A0A3Q7XUY5_URSAR/542-630  AC A0A3Q7XUY5.1
#=GS A0A0A0MQU7_HUMAN/542-630  AC A0A0A0MQU7.1
#=GS A0A3L8S783_CHLGU/546-633  AC A0A3L8S783.1
#=GS A0A2K5RXU0_CEBCA/542-630  AC A0A2K5RXU0.1
#=GS A0A151N4D0_ALLMI/546-633  AC A0A151N4D0.1
#=GS A0A060VVG2_ONCMY/505-557  AC A0A060VVG2.1
#=GS A0A384A9U4_BALAS/523-611  AC A0A384A9U4.1
#=GS A0A3B4ELV7_PYGNA/503-572  AC A0A3B4ELV7.1
#=GS HNF1A_RAT/540-627         AC P15257.1
#=GS F5H0K0_HUMAN/549-637      AC F5H0K0.1
#=GS I3JYX7_ORENI/492-577      AC I3JYX7.1
#=GS M3ZMP9_XIPMA/490-559      AC M3ZMP9.1
#=GS G1LP62_AILME/542-630      AC G1LP62.1
#=GS A0A452F3L1_CAPHI/544-630  AC A0A452F3L1.1
#=GS HNF1A_SALSA/506-558       AC Q91474.1
#=GS A0A2K5TN53_MACFA/486-574  AC A0A2K5TN53.1
#=GS A0A1S2WYW7_SALSA/506-558  AC A0A1S2WYW7.1
#=GS A0A2K6NLC7_RHIRO/573-661  AC A0A2K6NLC7.1
#=GS G3HI63_CRIGR/579-667      AC G3HI63.1
#=GS A0A1U7R9V2_ALLSI/546-633  AC A0A1U7R9V2.1
#=GS H2NIW9_PONAB/258-346      AC H2NIW9.1
#=GS A0A3P9Q6T1_POERE/480-549  AC A0A3P9Q6T1.1
#=GS I3JYX6_ORENI/489-558      AC I3JYX6.1
#=GS A0A3Q0SKQ4_AMPCI/494-563  AC A0A3Q0SKQ4.1
#=GS A0A3Q3WMR0_MOLML/464-533  AC A0A3Q3WMR0.1
A0A226P131_COLVI/546-633             ..........................a-FTPDSETHTDSGIHTPV.SQAPAIHLQNQDT.....T-IQHLQPGPRL.TSSP.A.............VSSSSLVLYQSSDSTNSH.SQL.LPSTHNVIETFISTQMASST....
A0A3B5AJJ9_9TELE/490-559             ...........................ILTADPEEQTDPPLQE--.---DSLHLQPHTP.....VP--------A-.----.-.............-SSESLELYPASQSTESHpSHL.LSPSPPDISSYIPAQMVSTA....
A0A1S3WEG7_ERIEU/540-627             ...........................VFTSEAEASSESGLPTPV.SQATTIHIPNQDP.....GGIQHLQP-HRL.SASP.S.............VSSSSLVLYQSSDSTNGH.SHL.LPSSHSVIETFISTQMASSS....
E0YMJ1_HUMAN/138-226                 ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....ASIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGQ.SHL.LPSNHSVIETFISTQMASSS....
A0A2Y9EP35_PHYMC/543-631             ...........................VFTSDAEASGESGLHTPA.SQAATIHIPSQDP.....AGIQHLQPTHRL.SASP.T.............VSSSSLVLYQSSDSTNGH.GHL.LPSNHSVIETFISTQMASSS....
G7N601_MACMU/542-630                 ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A2K6KTK9_RHIBE/365-453             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNSH.SHL.LPSNHSVIETFISTQMASSS....
A0A3Q7UW39_VULVU/542-630             ...........................VFTSDTEASSESGLHTPA.SQTTTIHIPSQDP.....VGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSNNGH.SHL.LPSNHSVIETFISTQMASSS....
HNF1A_MOUSE/540-627                  ...........................VFTSDTEASSEPGLHEPP.SPATTIHIPSQDP.....SNIQHLQPAHRL.STSP.T.............VSSSSLVLYQSSDS-NGH.SHL.LPSNHSVIETFISTQMASSS....
A0A384DFU3_URSMA/586-674             ...........................VFTADTEASSESGLHTPA.SQTTTIHIPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSNNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A2K6CWL8_MACNE/573-661             ...........................VFTSDTEASSESGLHTPA.SQATTLHIPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A3Q1IZ85_ANATE/490-559             ...........................ILTTDPEDDTDPPLQE--.---DSLHMQPHTP.....VP--------A-.----.-.............-SSESLELYPASQATESHqSHL.LSPSPTDISSYMPSQMVSTA....
A0A2K6KT95_RHIBE/542-630             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNSH.SHL.LPSNHSVIETFISTQMASSS....
G1PCX9_MYOLU/539-627                 ...........................VFISDTEASSESGLHTPA.SQATTIHIPSQDP.....AGIQHLQPSHRL.SASP.P.............VSSSSLVLYQSSESTNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A3Q1B664_AMPOC/493-562             ...........................ILTADPEEQSDPPLQE--.---DSLHLQPHTP.....VP--------A-.----.-.............-SSESLELYPASQSTESHpSHL.LSPSPPDISSYIPTQMVSTA....
A0A1L8I0A9_XENLA/509-593             ..........ltpskqvvshhptahgd------------------.--SPGSQLHNQDS.....S-ILHLHPSHRL.SPIP.T.............VSSASLIHYHNSSSPENH.SHL.LSPSHNTIDSFISTQMASSS....
A0A2K6SK79_SAIBB/542-630             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............MSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
B7ZRG9_XENLA/420-499                 ........................qvv------------PLHTTAhGDAPGSQLQNQDS.....S-ILHLPLCHRL.SPIP.T.............VSSASLVHYHNSSSPENH.SHL.LSPSHNTIDSFISTQMASSS....
A0A340WMF4_LIPVE/543-631             ...........................VFTSDAEASSESGLHTPA.SQAATIHIPSQDP.....AGIQHLQPTHRL.SASP.T.............VSSSSLVLYQSSDSTNGH.GHL.LPSNHSVIETFISTQMASSS....
L9KRL7_TUPCH/542-630                 ...........................VFTSDPEAAGESGLHTPA.SQATTLHVPNQDS.....AGIQHLQPTHRL.SASP.T.............VSSSSLVLYQSSDSTNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A2R8MMA5_CALJA/568-656             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............MSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A3B3Z7W1_9GOBI/489-558             ...........................ILTADQDEDTDTPLEE--.---ESLHLQPHTP.....VP----------.----.-.............ASSESLELYPSSQSTESHqCHL.LSPSPPDISSYMPSQLVSTA....
A0A2K5NW02_CERAT/573-661             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A4D9DWM2_9SAUR/546-633             ...........................VFTSESETHTESGIHTSV.SQTPTIHLQNQDT.....T-IQHLQPGHRL.TPSP.A.............VSSSSLVLYHSSDSTNSH.SHL.LPSTHSVIETFIPTQMASST....
A0A402EDU5_9SAUR/557-643             ...........................VFTSDSEAHAETGMHTPP.SEASTIHLQNQEA.....A-IQHLPPSHRL.SSSP.A.............VSSSNLILYQTSDS-NNH.SHL.LPSAHGVIETFISTQMASST....
A0A2I3G3A5_NOMLE/324-412             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A3Q3WWC6_MOLML/459-528             ...........................ILTADPEEQTDSPIRE--.---ESLHLQPHTP.....VP--------A-.----.-.............-SSESLELFPASQTSDSQqSHL.LSPSPTDISSFIPSQLVSTA....
H0WZU1_OTOGA/542-630                 ...........................VFTSDPEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPTHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHGVIETFISTQMASSS....
K7G2U5_PELSI/545-632                 ...........................VFTSESETHTESGIHTSV.SQTPTIHLQNQDT.....A-IQHLQPSHRL.TPSP.A.............VSSSNLVLYQSSDSTNSH.SHL.LPSTHSVIETFIPTQMASST....
A0A218V2Q6_9PASE/546-633             ..........................a-FTPDSETHTESGMHTPV.SQAPTIHLQNQDT.....T-IQHLQPGPRL.TSSP.A.............VSSSSLVLYQSSDSTNSH.SQL.LSSTHNVIETFISTQMASST....
H0V9M5_CAVPO/539-627                 ...........................VFTSDTEASSESGLHAPA.SPATTIHIPSQDP.....AGIQHLQPAHRL.STSP.T.............VSSSSLVLYQSSDSTNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A3Q1GUD8_9TELE/508-577             ...........................ILTADPEEQSDPPLQE--.---DSLHLQPHTP.....VP--------A-.----.-.............-SSESLELYPASQSTESHpSHL.LSPSPPDISSYIPTQMVSTA....
HNF1A_HUMAN/542-630                  ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGQ.SHL.LPSNHSVIETFISTQMASSS....
A0A1D5R0W9_MACMU/573-661             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A401P8V3_SCYTO/163-247             ...........................VLTLNSESQSENQIHAS-.--VQQLPLQNLDG.....S-IQHIHRVSSS.PAIT.T.............VSSGSLVMYQNTQSADSN.NHL.LSPSHSSIETFIPQQMASTA....
A0A3Q2H035_HORSE/365-453             ...........................VFTTDTEASSESGLHPPV.SQATTIHIPSQDS.....AGIQHLQPAHRL.STSP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A2K6GAP9_PROCO/543-631             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHGVIETFISTQMASSS....
A0A3B3CDH6_ORYME/490-559             ...........................ILTTDPEEQTDPPLQE--.---DSMHLQPHTP.....V-----------.----.P.............VSSESLELYSSSQTTERHqSHL.LSPSPTDISSYMPTQMVSTA....
A0A2Y9SHL3_PHYMC/554-642             ...........................VFTSDAEASGESGLHTPA.SQAATIHIPSQDP.....AGIQHLQPTHRL.SASP.T.............VSSSSLVLYQSSDSTNGH.GHL.LPSNHSVIETFISTQMASSS....
A0A1A6HQR7_NEOLE/311-354             .....................tgseek------------------.-------------.....------------.----.-.............---NSLVLYQSSDSTNGH.SHL.LPSNHGVIETFISTQMASSS....
A0A1S2ZVP4_ERIEU/533-620             ...........................VFTSEAEASSESGLPTPV.SQATTIHIPNQDP.....GGIQHLQP-HRL.SASP.S.............VSSSSLVLYQSSDSTNGH.SHL.LPSSHSVIETFISTQMASSS....
G3WPM8_SARHA/544-636                 ...........................VFSSDSEAPSESGLHTPV.SQASAIHIPSQDPeagerAGAQGSRSSPA-.TLAS.A.............VSSSSLVLYQGSDSTSSH.SQL.LSSNHGVIETFISTHMASSS....
A0A2U3VNN1_ODORO/542-630             ...........................VFTSDTEASSESGLHTPA.SQTTTIHIPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSPDSSHGH.GHL.LPANHSVIETFISTQMASSS....
H3C3K4_TETNG/522-596                 .........................cs--STDEEDQTGSPMQE--.---DSLHMQPNTP.....IPAP--------.-PTF.E.............ASSESLELYPPSQQSDSHpSHL.LSPSPSDI-SYIPAQMASTA....
H0ZHD2_TAEGU/545-632                 ..........................a-FTPDSETHTESGMHTPV.SQAPTIHLQNQDT.....T-IQHLQPGPRL.TSSP.A.............VSSSSLVLYQSSDSTNSH.SQL.LSSTHNVIETFISTQMASST....
A0A2Y9DQ97_TRIMA/542-630             ...........................VFTSDTEVSSESGLHTSV.SQATTIHIPSQDP.....TGIQHLQPAHRL.STSP.T.............VSSSSLVLYQSSDSTNSH.SHL.LPTNHSVIETFISTQMASSS....
A0A0D9S4M1_CHLSB/542-631             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T............aVSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
G1S1E9_NOMLE/449-537                 ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A3Q4M2M0_NEOBR/489-558             ...........................ILTTDPEEQEDAALQE--.---DSLNMQPHSP.....G-----------.----.P.............VSSESLELYPSSQATERHqSHL.LSPSPTEISSYIPAQMVSTA....
HNF1A_CHICK/546-633                  ..........................a-FTSDSETHTDSGIHTPV.SQAPAIHLQNQDT.....A-IQHLQSGPRL.TPSP.A.............VSSSSLVLYQSSDSTNSH.SQL.LPSTHNVIETFISTQMASST....
G3QNW9_GORGO/542-630                 ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A2K6KTB1_RHIBE/573-661             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNSH.SHL.LPSNHSVIETFISTQMASSS....
A0A2K6CWL6_MACNE/542-630             ...........................VFTSDTEASSESGLHTPA.SQATTLHIPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
W5PWE7_SHEEP/567-653                 ...........................VFSSDAEASSESGLHTRR.PPPPPIHIPGQDP.....AGIQQLQPSHRL.SASP.T.............VSSSSLVLYQSSDSTNGH.--L.LPSNHGVIETFISTQMASSS....
A0A2I2Y531_GORGO/365-453             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
F1PJ35_CANLF/542-630                 ...........................VFTSDAEASSESGLHTPA.SQTTTIHIPSQDP.....VGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSNNGH.SHL.LPSNHSVIETFISTQMASSS....
W5KDZ5_ASTMX/521-567                 .......................sspi------------------.-------------.....------------.----.P.............VSSGSLELYSQSQSSETHtSHL.LASPPGEIDPYIPAQMVSTA....
A0A3B3X773_9TELE/492-561             ...........................ILTADPEEETDSPLQE--.---DSLHLQPHTP.....VP--------A-.----.-.............-SSESLELYPSSQTTERHqSHL.LSPSPTDIGSYMPTQMVSTA....
A0A2K6NLD8_RHIRO/365-453             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNSH.SHL.LPSNHSVIETFISTQMASSS....
A0A2U9BT26_SCOMX/484-553             ...........................ILTADPEEQTDPTLQE--.---DSLHLQRHTP.....VP--------A-.----.-.............-SSGSLELYPASQTTDSHqSHL.LSPSPTDINSYIPTQLVSTA....
A0A2K5J3N0_COLAP/573-661             ...........................VFTSDPEASSESGLHTPA.SQATTLHVPSQDP.....ASIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A384A9N0_BALAS/539-627             ...........................VFTSDAEASSESGLHTPA.SQAATIHIPSQDP.....AGIQHLQPTHRL.SASP.T.............VSSSSLVLYQSSDSANGH.GHL.LPSNHSVIETFISTQMASSS....
F2Z4S1_DANRE/489-559                 .........................il--TTDPEGHTESAIEE--.---DSLHLQSTSP.....------------.---E.A.............GSSGSLDLYPQSQTSETHsSHLqLSSPAGDIDPYIPAQMVSTA....
A0A1D5QUU5_MACMU/373-445             placdraphphipgtqeaallpqvfts------------------.-------------.....------------.DTEA.S.............MSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A2Y9LA27_DELLE/543-631             ...........................VFTSDAEASSESGLHTPA.SQAATIHIPSQDP.....AGIQHLQPTHRL.SASP.T.............VSSSSLVLYQSSDSTNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A3P8Z6V0_ESOLU/488-557             ...........................ILTTDPEEQTDQPIQA--.---DSLHLQSPSP.....V-----------.----.P.............VSSGSIELYPPSQSSETHpSHL.LSSLPADISSYIPAQMVSTA....
E0YMI9_HUMAN/363-451                 ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....ASIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGQ.SHL.LPSNHSVIETFISTQMASSS....
F6Q5D3_MONDO/541-572                 ...........................VFSSDSEAPSESGLHTPV.SQASTIHIPSQDP.....------------.----.-.............------------------.---.--------------------v...
A0A384A9M2_BALAS/543-631             ...........................VFTSDAEASSESGLHTPA.SQAATIHIPSQDP.....AGIQHLQPTHRL.SASP.T.............VSSSSLVLYQSSDSANGH.GHL.LPSNHSVIETFISTQMASSS....
U3JYI0_FICAL/548-635                 ..........................a-FTPDSETHTESGMHTPV.SQAPTIHLQNQDT.....T-IQHLQPGPRL.TSSP.A.............VSSSSLVLYQSSDSTNSH.SQL.LPSTHNVIETFISTQMASST....
H2MXK2_ORYLA/490-558                 ...........................ILTTDPEEQTDPPLQE--.---DSMHLQPHTP.....VP--------A-.----.-.............-SSESLELYSSSQTTERHqSLL.LSPSQTDISSYMPTQMA---yr..
A0A096MVZ6_PAPAN/549-637             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A3P8VSE4_CYNSE/478-547             ...........................ILTSDPEEQTDQSLPE--.---DSLHLQPQTP.....VP--------A-.----.-.............-SSESLELYPSSQASDSHqSHL.LSPSPADISSYIPAQLVSTA....
A0A2K5TN37_MACFA/510-598             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A087Y4Z6_POEFO/492-561             ...........................ILTADPEEETDSPLQE--.---DSLHLQPHTP.....VP--------A-.----.-.............-SSESLELYPSSQTTERHqSHL.LSPSPTDIGSYMPTQMVSTA....
F1MD26_BOVIN/544-632                 ...........................VFTSDAEASSESGLHTPV.SQTTTIHIPGQDP.....AGIQQLQPSHRL.SASP.T.............VPSSSLVLYQSSDSTNGH.SHL.LPSNHSVTETFISTQMASSS....
A0A3B4F234_9CICH/489-558             ...........................ILTTDPEEQEDAPLQE--.---DSLNMQPHSP.....A-----------.----.P.............VSSESLELYPSSQATESHqSHL.LSPSPTEISSYIPAQMVSTA....
A0A2U4CJZ3_TURTR/571-659             ...........................VFTSDAEASSESGLHTPA.SQAATIHIPSQDP.....AGIQHLQPTHRL.SASP.T.............VSSSSLVLYQSSDSTNGH.SHL.LPSNHSVIETFISTQMASSS....
H9KX05_CALJA/549-637                 ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............MSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A2K5J3U0_COLAP/365-453             ...........................VFTSDPEASSESGLHTPA.SQATTLHVPSQDP.....ASIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A452IJ85_9SAUR/363-450             ...........................VFTSESETHTESGIHTSV.SQTPTIHLQNQDT.....T-IQHVQPGHLL.TPSP.A.............VSSSSLVLYHSSDSTNSH.SHL.LPSTHSVIETFIPTQMASST....
A0A2I3MWC9_PAPAN/573-661             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A2Y9KI17_ENHLU/542-630             ...........................VFASDTEASSESGLHTPA.SQTTTIHIPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSNNGH.SHL.LPSNHSVIETFISTQMASSS....
M3XW08_MUSPF/544-632                 ...........................VFASDTEASSESGLHTPA.SQTTTIHIPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A2K5NWJ9_CERAT/542-630             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A2K6GAL3_PROCO/573-661             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHGVIETFISTQMASSS....
A0A1U7TI53_TARSY/138-226             ...........................VFTSDTKASSASGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.GHL.LPSSHSVIETFISMQMASSS....
R0L7K0_ANAPL/546-633                 ..........................a-FTSDSETHTESGMHTPV.SQAPTIHLQNQDT.....T-IQHLQPGPRL.TSSP.A.............VSSSSLVLYQSSDSTNSH.SQL.LPSSHNVIETFISTQMASST....
A0A3B4Y0T5_SERLL/509-578             ...........................ILTADPEEQTDPPLQE--.---DSLHLQPNTP.....V--------PA-.----.-.............-SSESLELYPASQTTDSHqSHL.LSPSPTDISSYIPTQMVSTA....
A0A2R8ZHP9_PANPA/549-637             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A401SHS4_CHIPU/572-656             ...........................VLTLNSESQSENQINT--.-SAQQVPLQNLEG.....S-IQHIHRISAS.PAIT.T.............VSSGSLVMYQNTQPADGH.SHL.LSPSQSSIETFISPQMSSTA....
A0A3B3QQC7_9TELE/482-555             ...............tavrqilatdpd------------------.---------DQSD.....PPIQDSLHLAS-.-NSPvP.............VTSGGLELYPTSQPGEEHtPHL.LTSPSADIDPYIPTEMVSSA....
A0A2K5RXZ0_CEBCA/364-452             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............MSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A3Q0D4W2_MESAU/548-636             ...........................VFTSDTEASSEPGLHEPS.SPATTIHIPSQDP.....SSIQHLQPAHRL.STSP.T.............VSSSSLVLYQSSDSTNGH.SHL.LPSNHGVIETFISTQMASSS....
A0A3Q3AFP1_KRYMA/490-559             ...........................ILTTDPEDGTDSPLQE--.---DSLHLQPHTP.....VP--------A-.----.-.............-SSESLELYPSSQMAERHqSHI.LSPSPTDISSYMPTQMVSTA....
A0A1V4JRS9_PATFA/543-630             ..........................a-FTSDSETHTESGMHTPV.SQAPTIHLQNQDT.....T-IQHLQPGPRL.TPSP.A.............VSSSSLVLYQSSDSTNSH.TQL.LPSTHNAMETFISTQMASST....
A0A2K5ZT55_MANLE/573-661             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A1S3WE68_ERIEU/539-626             ...........................VFTSEAEASSESGLPTPV.SQATTIHIPNQDP.....GGIQHLQP-HRL.SASP.S.............VSSSSLVLYQSSDSTNGH.SHL.LPSSHSVIETFISTQMASSS....
A0A1U7QQX3_MESAU/541-629             ...........................VFTSDTEASSEPGLHEPS.SPATTIHIPSQDP.....SSIQHLQPAHRL.STSP.T.............VSSSSLVLYQSSDSTNGH.SHL.LPSNHGVIETFISTQMASSS....
G3TJQ6_LOXAF/542-630                 ...........................VFTSDTEVSSESGLHTSV.SQATTIHIPSQDP.....AGIQHLQPAHRL.STSP.T.............VSSSSLVLYQSSDSTNSH.SHL.LPTNHSVIETFISTQMASSS....
F7CR09_HORSE/559-647                 ...........................VFTTDTEASSESGLHPPV.SQATTIHIPSQDS.....AGIQHLQPAHRL.STSP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A2I3M205_PAPAN/365-453             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A452SA16_URSAM/542-630             ...........................VFTADTEASSESGLHTPA.SQTTTIHIPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSNNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A1L8HQ75_XENLA/525-604             ........................qvv------------PLHTTAhGDAPGSQLQNQDS.....S-ILHLPLCHRL.SPIP.T.............VSSASLVHYHNSSSPENH.SHL.LSPSHNTIDSFISTQMASSS....
A0A2U3ZC55_ODORO/549-637             ...........................VFTSDTEASSESGLHTPA.SQTTTIHIPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSPDSSHGH.GHL.LPANHSVIETFISTQMASSS....
A0A2I3T729_PANTR/573-661             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A2K5ZT33_MANLE/542-630             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
M3XHE8_LATCH/545-595                 ...........................VLTLDTENQSETQISTSV.PQMSVVHLQNQDG.....T-IQHVQTGHRV.SSSP.A.............------------------.---.--------------------gttg
A0A2Y9DQC9_TRIMA/549-637             ...........................VFTSDTEVSSESGLHTSV.SQATTIHIPSQDP.....TGIQHLQPAHRL.STSP.T.............VSSSSLVLYQSSDSTNSH.SHL.LPTNHSVIETFISTQMASSS....
A0A3Q7TPJ5_VULVU/572-660             ...........................VFTSDTEASSESGLHTPA.SQTTTIHIPSQDP.....VGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSNNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A226NBL9_CALSU/546-633             ..........................a-FTSDSETHTDSGIHTPV.SQAPAIHLQNQDT.....T-IQHLQPGPRL.TSSP.A.............VSSSSLVLYQSSDSTNSH.SQL.LPSTHNVIETFISTQMASST....
H3BXN4_TETNG/521-590                 ...............lcsstdeedqtg------------------.-------------.....SPMQE-DSLHMQpNTPI.P.............ASSESLELYPPSQQSDSHpSHL.LSPSPSDI-SYIPAQMASTA....
M7C177_CHEMY/526-613                 ...........................VFTSESETHTESGIHTSV.SQTPTIHLQNQDT.....T-IQHLQPGHRL.TPSP.A.............VSSSSLVLYHSSDSTNSH.SHL.LPSTHSVIETFIPTQMASST....
M3WBT5_FELCA/561-649                 ...........................VFASDTEASSESGLHTPA.SQTTTIHIPSQDP.....AGIQPLQPTHRL.SASP.T.............VSSSSLVLYQSSDSNDGH.SHL.LPSNHSVIETFISTQMASSS....
A0A3Q3LS37_9LABR/507-554             .....................dslpvp------------------.-------------.....------------.----.-.............ASSESLDLYPASESTESHqSHL.LSPSPTDISSYIPSQMVSTA....
A0A2K5NWR4_CERAT/365-453             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A2K6GAM0_PROCO/366-454             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHGVIETFISTQMASSS....
A0A2K5J3P3_COLAP/542-630             ...........................VFTSDPEASSESGLHTPA.SQATTLHVPSQDP.....ASIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
F6Q5D3_MONDO/571-612                 ..........................p------------------.-------------.....------------.----.-.............VSSSSLVLYQGSDSTNSH.SQL.LSSNHGVIETFISTHMASSS....
U3I461_ANAPP/546-633                 ..........................a-FTSDSETHTESGMHTPV.SQAPTIHLQNQDT.....T-IQHLQPGPRL.TSSP.A.............VSSSSLVLYQSSDSTNSH.SQL.LPSSHNVIETFISTQMASST....
H2Q721_PANTR/549-637                 ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A3B3UEF3_9TELE/492-561             ...........................ILTADPEEETDSPLQE--.---DSLHLQPHTP.....VP--------A-.----.-.............-SSESLELYPSSQTTERHqSHL.LSPSPTDIGSYMPTQMVSTA....
A0A2R8MBN5_CALJA/364-452             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............MSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A2U3Y2C6_LEPWE/542-630             ...........................VFTSDTEASSESGLHTPA.SQTTTIHIPSQDP.....AGIQHLQPAHRL.SASP.T.............VPSSSLVLYQSSDSNNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A2K5C9H9_AOTNA/547-635             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............MSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A2I4CK97_9TELE/491-560             ...........................ILTADPEEGTDSPLQD--.---DSLHLQPHTP.....VP--------A-.----.-.............-SSESLELYPSSQMTERHpSHI.LSPSPTDISSYMPTQMVSTA....
A0A3M0JYB0_HIRRU/546-633             ..........................a-FTPDSETHTESGMHTPV.SQAPTIHLQNQDT.....T-IQHLQPGPRL.TSSP.A.............VSSSSLVLYQSSDSTNSH.SQL.LPSTHNVIETFISTQMASST....
A0A3Q2VGG5_HAPBU/489-558             ...........................ILTTDPEEQEDATLQE--.---DSLNMQPHSP.....A-----------.----.P.............VSSGSLELYPSSQATESHqSHL.LSPSPTEISSYIPAQMVSTA....
A0A2K6CWT9_MACNE/365-453             ...........................VFTSDTEASSESGLHTPA.SQATTLHIPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A2Y9KVP7_ENHLU/549-637             ...........................VFASDTEASSESGLHTPA.SQTTTIHIPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSNNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A3Q7X8Z5_URSAR/571-659             ...........................VFTADTEASSESGLHTPA.SQTTTIHIPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSNNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A2K5TN46_MACFA/350-438             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A1L1RPG1_CHICK/546-633             ..........................a-FTSDSETHTDSGIHTPV.SQAPAIHLQNQDT.....A-IQHLQSGPRL.TPSP.A.............VSSSSLVLYQSSDSTNSH.SQL.LPSTHNVIETFISTQMASST....
A0A3Q7T3X7_VULVU/542-591             ...........................VFTSDTEASSESGLHTPA.SQTTTIHIPSQDP.....VGIQHLQPAHRL.SASP.T.............------------------.---.--------------------ge..
A0A2I2ZCZ2_GORGO/573-661             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A1S3F1B9_DIPOR/542-630             ...........................VFTSDTEASSESGLHAPA.SPATTIHIPSQDP.....GSIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDATNGH.GHL.LPSNHGVIETFISTQMASSS....
A0A3P9ASB7_9CICH/489-558             ...........................ILTTDPEEQEDAPLQE--.---DSLNMQPHSP.....A-----------.----.P.............VSSESLELYPSSQATESHqSHL.LSPSPTEISSYIPAQMVSTA....
A0A1D5QAI7_MACMU/582-670             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A3P8N5V0_ASTCA/489-558             ...........................ILTTDPEEQEDAPLQE--.---DSLNMQPHSP.....A-----------.----.P.............VSSESLELYPSSQATESHqSHL.LSPSPTEISSYIPAQMVSTA....
A0A2R8ZKU2_PANPA/573-661             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A2K5ZT62_MANLE/365-453             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A3Q0DPP0_TARSY/145-233             ...........................VFTSDTKASSASGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.GHL.LPSSHSVIETFISMQMASSS....
A0A2D0QVD0_ICTPU/506-575             ....................tlssdse------------------.---------EHTN.....TPIQEE-SLHLQsSSPV.P.............VSSSSLDLYPQTQSSESHtSHL.LTSSPSDIGPYIPAQMVSTA....
A0A2I3TKC6_PANTR/365-453             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A452IJB6_9SAUR/546-633             ...........................VFTSESETHTESGIHTSV.SQTPTIHLQNQDT.....T-IQHVQPGHLL.TPSP.A.............VSSSSLVLYHSSDSTNSH.SHL.LPSTHSVIETFIPTQMASST....
A0A3P8VF60_CYNSE/139-191             ....................nnfgcvr------------------.-------------.....------------.-LSS.S.............ASSESLELYPSSQASDSHqSHL.LSPSPADISSYIPTQLVSTA....
A0A0A0MTK8_HUMAN/573-661             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....ASIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGQ.SHL.LPSNHSVIETFISTQMASSS....
A0A3B5AGK0_9TELE/485-554             ...........................ILTADPEEQTDPPLQE--.---DSLHLQPHTP.....VP--------A-.----.-.............-SSESLELYPASQSTESHpSHL.LSPSPPDISSYIPAQMVSTA....
A0A0Q3U1U1_AMAAE/543-630             ..........................a-FTPESETHTESGMHTPV.SQAPTIHLQNQDT.....T-IQHLQPGPRL.TSSP.A.............VSSSSLVLYQSSDSANSH.SQL.LPSTHNVIETFISTQMASST....
A0A2I3HRE5_NOMLE/473-561             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A2K6NLC5_RHIRO/542-630             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNSH.SHL.LPSNHSVIETFISTQMASSS....
A0A091CZU1_FUKDA/542-630             ...........................VFTPDTEASSESGLHAPV.SPATTIHIPSQDP.....GGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSTNGH.SHL.LPSSHSVIETFISTQMASSS....
A0A3Q2E0K2_CYPVA/489-558             ...........................ILTADPDEDTESPLQE--.---DSLHLQPQTP.....VP--------A-.----.-.............-SSESLELYPSSQTTERHqSHL.LSPSPTDISSYMPTQMVSTA....
A0A3Q3KPB0_9TELE/508-577             ...........................ILTADHEEPEDPPLQE--.---GSLHLQPHTP.....VP----------.----.-.............ASSDSLELYPASQTTTSHqSHL.LSPSPTDISSYIPTQMVSTA....
G3PGQ4_GASAC/494-563                 ...........................ILTADPEEQRGSPLEE--.---DSLHLQPHTP.....VP--------A-.----.-.............-SSDRLELYPASQSTESHqSHL.LSPSPADISAYIPTQMVSTA....
Q4PJJ8_PIG/542-630                   ...........................VFTSDTEASSESGLHTPA.SQATTIHIPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSTNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A3B3Z7Q6_9GOBI/487-556             ...........................ILTADQDEDTDTPLEE--.---ESLHLQPHTP.....VP----------.----.-.............ASSESLELYPSSQSTESHqCHL.LSPSPPDISSYMPSQLVSTA....
A0A3Q7Y2Q5_URSAR/586-674             ...........................VFTADTEASSESGLHTPA.SQTTTIHIPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSNNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A2D0QXA6_ICTPU/510-579             ....................tlssdse------------------.---------EHTN.....TPIQEE-SLHLQsSSPV.P.............VSSSSLDLYPQTQSSESHtSHL.LTSSPSDIGPYIPAQMVSTA....
G5AWX7_HETGA/542-630                 ...........................VFTSDTEASSESGLHAPV.SPATTIHIPSQDP.....GGIQHLQPAHRL.STSP.T.............VSSSSLVLYQSSDSTNGH.SHL.LPSSHSVIETFISTQMASSS....
A0A3P8SCV4_AMPPE/493-562             ...........................ILTADPEEQSDPPLQE--.---DSLHLQPHTP.....VP--------A-.----.-.............-SSESLELYPASQSTESHpSHL.LSPSPPDISSYIPTQMVSTA....
A0A3Q7WCN0_URSAR/586-687             ...........................VFTADTEASSESGLHTPA.SQTTTIHIPSQDP.....AGIQHLQPAHRL.SASP.TgeqpfpapsageeVSSSSLVLYQSSDSNNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A3B4T694_SERDU/492-561             ...........................ILTADPEEQTDPPLQE--.---DSLHLQPNTP.....V--------PA-.----.-.............-SSESLELYPASQTTDSHqSHL.LSPSPTDISSYIPTQMVSTA....
L5KWI4_PTEAL/380-468                 ...........................VFTSDNEASSESGLHTPA.SQATTIHIPSQDP.....AGIQHLQPSHRL.SASP.T.............VSSSSLVLYQSSESTNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A3Q0D5U9_MESAU/451-539             ...........................VFTSDTEASSEPGLHEPS.SPATTIHIPSQDP.....SSIQHLQPAHRL.STSP.T.............VSSSSLVLYQSSDSTNGH.SHL.LPSNHGVIETFISTQMASSS....
A0A2I0LZ40_COLLI/543-630             ..........................a-FTSDSETHTESGMHTPV.SQAPTIHLQNQDT.....T-IQHLQPGPRL.TSSP.A.............VSSSSLVLYQSSDSTNSH.SQL.LPSTHNAMETFISTQMASST....
A0A2K5C9I1_AOTNA/364-452             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............MSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
H2UWZ0_TAKRU/468-536                 ...........................ILSADQEDHTDSPVHE--.---DSLQLQPNTP.....V--------P--.----.-.............ASSESLELYPPSQPSDSHqSHL.LSPSPSDI-SYIPAQMASTA....
A0A2K6SKA7_SAIBB/364-452             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............MSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A2R8ZNZ9_PANPA/365-453             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A2K5RXT3_CEBCA/572-660             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............MSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A3Q7XUY5_URSAR/542-630             ...........................VFTADTEASSESGLHTPA.SQTTTIHIPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSNNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A0A0MQU7_HUMAN/542-630             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....ASIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGQ.SHL.LPSNHSVIETFISTQMASSS....
A0A3L8S783_CHLGU/546-633             ..........................a-FTPDSETHTESGMHTPV.SQAPTIHLQNQDT.....T-IQHLQPGPRL.TSSP.A.............VSSSSLVLYQSSDSTNSH.SQL.LPSPHNVIETFISTQMASST....
A0A2K5RXU0_CEBCA/542-630             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............MSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A151N4D0_ALLMI/546-633             ...........................VFTSDSENHTESGIHTPV.SQTQTIHLQNQDT.....T-IQHLQPGPRL.TSSP.A.............ASSSSLVLYQSSDSTNSH.SHL.LPSTHSVIETFISAQMASST....
A0A060VVG2_ONCMY/505-557             .......................slhl------------------.-------------.....-----------Q.SPSPvP.............VSSGNLQLYPPSQSSETHpPHR.LSSSPADINSYIPAQMVSTA....
A0A384A9U4_BALAS/523-611             ...........................VFTSDAEASSESGLHTPA.SQAATIHIPSQDP.....AGIQHLQPTHRL.SASP.T.............VSSSSLVLYQSSDSANGH.GHL.LPSNHSVIETFISTQMASSS....
A0A3B4ELV7_PYGNA/503-572             ...........nlssdpedhtdrhiqe------------------.-------------.....------ESLHLQpSSPV.P.............VSSGSLELYSQTQSGDSHtSHL.LASPPGDIDPYIPSQMVSTA....
HNF1A_RAT/540-627                    ...........................VFTSDTEASSEPGLHEPS.SPATTIHIPSQDP.....SNIQHLQPAHRL.STSP.T.............VSSSSLVLYQSSDS-NGH.SHL.LPSNHGVIETFISTQMASSS....
F5H0K0_HUMAN/549-637                 ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....ASIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGQ.SHL.LPSNHSVIETFISTQMASSS....
I3JYX7_ORENI/492-577                 ...........................ILTTDPDEQEDAPLQE--.---DSLNMQPHSP.....APAQHRQKLHVTdTIKL.T.............VSSESLELYPSSQATESHqSHL.LSPSPTEISSYIPAQMVSTA....
M3ZMP9_XIPMA/490-559                 ...........................ILTADPEEETESPLQE--.---DSLHLQPHTP.....VP--------A-.----.-.............-SSESLELYPSSQTTERHqSHL.LSPSPTDIGSYMPTQMVSTA....
G1LP62_AILME/542-630                 ...........................VFTADTEASSEPGLHTPA.SQTTTIHIPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSNNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A452F3L1_CAPHI/544-630             ...........................VFSSDAEASSESGLHTPA.SQAAAIHIPGQDP.....AGIQQLQPSHRL.SASP.T.............VSSSSLVLYQSSDSTNGH.--L.LPSNHGVIETFISTQMASSS....
HNF1A_SALSA/506-558                  .......................slhl------------------.-------------.....-----------Q.SPSPvP.............VSSGNLQLYPPSQSSESHpPHR.LSSSPADINSYIPAQMVSTA....
A0A2K5TN53_MACFA/486-574             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A1S2WYW7_SALSA/506-558             .......................slhl------------------.-------------.....-----------Q.SPSPvP.............VSSGNLQLYPPSQSSESHpPHR.LSSSPADINSYIPAQMVSTA....
A0A2K6NLC7_RHIRO/573-661             ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNSH.SHL.LPSNHSVIETFISTQMASSS....
G3HI63_CRIGR/579-667                 ...........................VFTSDTEGSSEPGLHEPS.SPATTIHIPSQDP.....SSIQHLQPAHRL.STSP.T.............VSSSSLVLYQSSDSTNGH.SHL.LPSNHGVIETFISTQMASSS....
A0A1U7R9V2_ALLSI/546-633             ...........................VFTSDSENHTESGIHTPV.SQTQTIHLQNQDT.....T-IQHLQPGPRL.TSSP.A.............ASSSSLVLYQSSDSTNSH.SHL.LPSTHSVIETFISAQMASST....
H2NIW9_PONAB/258-346                 ...........................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASP.T.............VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS....
A0A3P9Q6T1_POERE/480-549             ...........................ILTADPEEETDSPLQE--.---DSLHLQPHTP.....VP--------A-.----.-.............-SSESLELYPSSQTTERHqSHL.LSPSPTDIGSYMPTQMVSTA....
I3JYX6_ORENI/489-558                 ...........................ILTTDPDEQEDAPLQE--.---DSLNMQPHSP.....A-----------.----.P.............VSSESLELYPSSQATESHqSHL.LSPSPTEISSYIPAQMVSTA....
A0A3Q0SKQ4_AMPCI/494-563             ...........................ILTTDPEEQEDTPLRE--.---DSLNLQPHSP.....A-----------.----.P.............VSSESLELYPSSQRTESHqSHL.LSPSPTEISSYIPPQMVSTA....
A0A3Q3WMR0_MOLML/464-533             ...........................ILTADPEEQTDSPIRE--.---ESLHLQPHTP.....VP--------A-.----.-.............-SSESLELFPASQTSDSQqSHL.LSPSPTDISSFIPSQLVSTA....
#=GC seq_cons                        ...........................VFTSDoEssSESGLHTPs.SQssTlHl.sQDP.....usIQHLQPuHRL.SuSP.o.............VSSSSLVLYQSSDSoNuH.SHL.LPSsHoVIETFISTQMASSS....
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