GenomeNet

Database: Pfam
Entry: HP0268
LinkDB: HP0268
Original site: HP0268 
#=GF ID   HP0268
#=GF AC   PF18618.1
#=GF DE   HP0268 
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF08406
#=GF GA   25.00 25.00;
#=GF TC   48.90 79.50;
#=GF NC   24.60 23.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   25916841
#=GF RT   Structure-based functional identification of Helicobacter pylori
#=GF RT   HP0268 as a nuclease with both DNA nicking and RNase activities.
#=GF RA   Lee KY, Lee KY, Kim JH, Lee IG, Lee SH, Sim DW, Won HS, Lee BJ;
#=GF RL   Nucleic Acids Res. 2015;43:5194-5207.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   HP0268 is a small, characterized protein that is conserved in H.
#=GF CC   pylori strains and consists of 80 amino acid residues with a
#=GF CC   molecular weight of approximately 9.5 kDa. HP0268 has nicking
#=GF CC   endonuclease and RNase activities, both of which are specific
#=GF CC   for a single-strand of nucleotides. It is structurally similar
#=GF CC   to small MutS-related (SMR) domains, that can be categorized
#=GF CC   roughly into three subfamilies according to their arrangement in
#=GF CC   the domain architecture.HP0268 falls into subfamily 3 that is
#=GF CC   found as stand-alone type proteins. It is proposed that HP0268
#=GF CC   has become an evolutionary intermediate between RNases and
#=GF CC   nicking endonucleases during H. pylori adaptation to the
#=GF CC   extremely acidic environment of the stomach [1].
#=GF SQ   94
#=GS S3YPR2_9PROT/1-80      AC S3YPR2.1
#=GS A0A099B5U9_9HELI/4-86  AC A0A099B5U9.1
#=GS C6RIR2_9PROT/1-80      AC C6RIR2.1
#=GS A0A172SSK5_CAMHY/1-80  AC A0A172SSK5.1
#=GS Q7VGP7_HELHP/1-86      AC Q7VGP7.1
#=GS A0A1W1WQJ2_9PROT/1-80  AC A0A1W1WQJ2.1
#=GS A0A222MXA2_9PROT/1-80  AC A0A222MXA2.1
#=GS V8CKG6_9HELI/1-82      AC V8CKG6.1
#=GS A0A099DRT6_9HELI/1-83  AC A0A099DRT6.1
#=GS D3UG84_HELM1/1-78      AC D3UG84.1
#=GS A0A1T5AKD9_9PROT/1-80  AC A0A1T5AKD9.1
#=GS A0A151CF31_9PROT/1-78  AC A0A151CF31.1
#=GS A0A292YBS1_9PROT/1-76  AC A0A292YBS1.1
#=GS A0A1W9PMI2_9HELI/1-80  AC A0A1W9PMI2.1
#=GS A0A268UAN0_9HELI/1-80  AC A0A268UAN0.1
#=GS Q0PB54_CAMJE/9-88      AC Q0PB54.1
#=GS A0A1G3TDQ6_9HELI/1-80  AC A0A1G3TDQ6.1
#=GS A0A2G1DH11_9PROT/1-80  AC A0A2G1DH11.1
#=GS A6DBC5_9PROT/1-76      AC A6DBC5.1
#=GS A0A076FAG1_9PROT/1-80  AC A0A076FAG1.1
#=GS V8CA71_9HELI/1-90      AC V8CA71.1
#=GS A0A0C2VTF9_9PROT/1-78  AC A0A0C2VTF9.1
#=GS A0A1Y1RAQ4_9PROT/1-80  AC A0A1Y1RAQ4.1
#=GS A7I0Q4_CAMHC/1-80      AC A7I0Q4.1
#=GS A0A1P8KQ01_9PROT/1-80  AC A0A1P8KQ01.1
#=GS A0A1B9FCB2_9PROT/1-80  AC A0A1B9FCB2.1
#=GS I7HE50_9HELI/1-83      AC I7HE50.1
#=GS A0A128EDU2_CAMFE/1-80  AC A0A128EDU2.1
#=GS Q7MR24_WOLSU/1-80      AC Q7MR24.1
#=GS A0A1B1U668_9HELI/1-79  AC A0A1B1U668.1
#=GS A0A1W6BVE9_9PROT/1-80  AC A0A1W6BVE9.1
#=GS D5V755_ARCNC/1-80      AC D5V755.1
#=GS A0A099VGB3_9HELI/1-84  AC A0A099VGB3.1
#=GS A0A2D0I8N2_9HELI/1-80  AC A0A2D0I8N2.1
#=GS A0A268T8T2_9HELI/1-80  AC A0A268T8T2.1
#=GS E7AD74_HELFC/1-82      AC E7AD74.1
#=GS A0A071LC11_9PROT/1-80  AC A0A071LC11.1
#=GS A0A1I5P9B2_9PROT/1-80  AC A0A1I5P9B2.1
#=GS A0A258X3H3_9PROT/1-80  AC A0A258X3H3.1
#=GS A0A099V6Q3_9HELI/1-84  AC A0A099V6Q3.1
#=GS A0A0B0Q8A1_9PROT/1-80  AC A0A0B0Q8A1.1
#=GS A0A1B8J8P6_9HELI/1-87  AC A0A1B8J8P6.1
#=GS A0A1V9VA19_9PROT/1-80  AC A0A1V9VA19.1
#=GS A0RQN6_CAMFF/1-80      AC A0RQN6.1
#=GS A0A268TSZ1_9HELI/1-80  AC A0A268TSZ1.1
#=GS A0A0A8H330_9PROT/1-80  AC A0A0A8H330.1
#=GS J0LDF2_9HELI/1-81      AC J0LDF2.1
#=GS B6BIG3_SULGG/1-80      AC B6BIG3.1
#=GS A0A268TJ09_9HELI/1-80  AC A0A268TJ09.1
#=GS A0A091AH50_9HELI/1-80  AC A0A091AH50.1
#=GS D1AZJ8_SULD5/1-80      AC D1AZJ8.1
#=GS C5ZVX2_9HELI/1-80      AC C5ZVX2.1
#=GS B9D4P2_CAMRE/1-80      AC B9D4P2.1
#=GS I2K5Y4_9PROT/1-78      AC I2K5Y4.1
#=GS A0A1S6U8F4_9PROT/1-80  AC A0A1S6U8F4.1
#=GS A0A0M5MG19_9PROT/1-80  AC A0A0M5MG19.1
#=GS F8KRG3_HELBC/1-81      AC F8KRG3.1
#=GS A0A099TYG1_9HELI/1-84  AC A0A099TYG1.1
#=GS T0JSB7_9HELI/1-80      AC T0JSB7.1
#=GS C8PFL0_9PROT/1-80      AC C8PFL0.1
#=GS A0A099TUI7_9HELI/1-80  AC A0A099TUI7.1
#=GS A0A1Y0HJZ8_9PROT/1-80  AC A0A1Y0HJZ8.1
#=GS A0A2A2GU85_9HELI/1-82  AC A0A2A2GU85.1
#=GS A6Q532_NITSB/1-80      AC A6Q532.1
#=GS Q30PR0_SULDN/1-80      AC Q30PR0.1
#=GS A8ERE8_ARCB4/1-80      AC A8ERE8.1
#=GS A0A1G3UE22_9HELI/1-80  AC A0A1G3UE22.1
#=GS A0A099UC78_9HELI/1-80  AC A0A099UC78.1
#=GS A0A1C0B8D5_9PROT/1-80  AC A0A1C0B8D5.1
#=GS A0A087MD64_9PROT/1-80  AC A0A087MD64.1
#=GS E7G5A2_9HELI/1-80      AC E7G5A2.1
#=GS E0UPC4_SULAO/1-80      AC E0UPC4.1
#=GS A6QCD1_SULNB/1-78      AC A6QCD1.1
#=GS H5VEW1_HELBI/1-81      AC H5VEW1.1
#=GS G2HSU5_9PROT/1-80      AC G2HSU5.1
#=GS A7GZE0_CAMC5/1-80      AC A7GZE0.1
#=GS T1CN70_9HELI/1-82      AC T1CN70.1
#=GS I0ERC6_HELCM/1-80      AC I0ERC6.1
#=GS A0A099VWP5_9HELI/1-80  AC A0A099VWP5.1
#=GS A0A0K2Y3V6_9HELI/1-80  AC A0A0K2Y3V6.1
#=GS B9KF50_CAMLR/30-109    AC B9KF50.1
#=GS A0A1X9STV5_9PROT/1-80  AC A0A1X9STV5.1
#=GS E6WZ14_NITSE/1-78      AC E6WZ14.1
#=GS A0A1G3TLZ6_9HELI/1-80  AC A0A1G3TLZ6.1
#=GS A0A268TQ87_9HELI/1-80  AC A0A268TQ87.1
#=GS K7SAZ0_9HELI/1-80      AC K7SAZ0.1
#=GS E6L964_CAMUP/1-80      AC E6L964.1
#=GS A0A2G2CTP1_9HELI/1-80  AC A0A2G2CTP1.1
#=GS B9L7T4_NAUPA/1-76      AC B9L7T4.1
#=GS O25047_HELPY/1-80      AC O25047.1
#=GS O25047_HELPY/1-80      DR PDB; 2MX0 A; 3-82;
#=GS A0A268U0H7_9HELI/1-80  AC A0A268U0H7.1
#=GS A0A099TF83_9HELI/1-84  AC A0A099TF83.1
#=GS A0A268U5L9_9HELI/1-81  AC A0A268U5L9.1
#=GS A0A099VUG2_9HELI/1-84  AC A0A099VUG2.1
S3YPR2_9PROT/1-80                 .MELKIARSEL....SKAPN........NISLSDIEKEVAKTG.....QRIFYFDRENQHKDLIALIEHFKKK.NMSAYLRTVKYGLDENEFMYEVHIL.
A0A099B5U9_9HELI/4-86             k-EIKLAKESL...kDSKSE........SISLAKMGEIVDKGGk...nGAFFYLSKDNQEKDLKKLESFFKAR.KRNIMLRELRYNMDTKDYIYELHVL.
C6RIR2_9PROT/1-80                 .MELKLARTQL....DAKPK........TISLEKIEAAFAKDP.....QQIFYFDRENSHKQLIALVEFFEEK.GLSVYHRTVKYGLDENDYMYEVHIL.
A0A172SSK5_CAMHY/1-80             .MELKLARTEL....DNKPK........TISLDKIEAAVAKDG.....GKIFYFDKENSHKELISLVEYFEEK.GLSVYHRTVKYGLDENDYMYEVHIL.
Q7VGP7_HELHP/1-86                 .MELKLAKSTLs.qaNAKNKvn....vaKISYEDMLKKCAQ-G.....EHIFYFDKENSHKEMQKVCASFQKA.GYNTYLNEVRYGLDEASYIYELHII.
A0A1W1WQJ2_9PROT/1-80             .MELKLARETL....KAKPK........TIDLEKIKTEVEKEG.....SKIFYFDRENSHKDLMDMVDKLESE.GFSVYFREVKYGLDENDYIYEVHII.
A0A222MXA2_9PROT/1-80             .MDVKLARTLL....DEKAK........SVSLKKLEELLEQEN.....QSFFYLDRENSKKTLTSLAQHFEKK.GLSVYYREVRYGLDSGDYMYEVHI-f
V8CKG6_9HELI/1-82                 .MELKLAPMDTanisQASTQ........TIAVESLLESTSS--.....LQVVYLDKQNSQKDLQKAKTLLESK.GKVVYMGEVRYGLDAKDFIYEFRIL.
A0A099DRT6_9HELI/1-83             .MELKLAKNTL....STNKKan....aaKITCEDILKKVAQ-G.....EHIFYFDRENSHKDMQKACAFFQKA.GLHTYLNEVRYGLDETSYIYELHIV.
D3UG84_HELM1/1-78                 .MELKLAKTDQ....EVESK........IITLQEIYEQASQ--.....ERFFYFSRDNKEKDLQKVLQSFVDK.KRSAKLDKISYGLDEKDFIYELHII.
A0A1T5AKD9_9PROT/1-80             .MELLFARNEL....NEKPK........KVQLDKIKEELQKSG.....EKIFYFDRDNSHKDMMALVDALEDE.GFNVYFREVKYGLADDEYMYEVHAL.
A0A151CF31_9PROT/1-78             .MKLKLARTTL....KAKPK........TIELKKLEEELAS--.....RSIFYFDKDNSHKELKELIEYFEEK.GYSVYMREVKYGLDDNEFIYEVHII.
A0A292YBS1_9PROT/1-76             .MTLKLIENDH....NA--K........EISMEEFLKNVKS--.....NSFYYFHKDTSYKNLKDLIDKLTEM.GYSVYFREVKYALDEGSYMYEMHIL.
A0A1W9PMI2_9HELI/1-80             .MELKVARTEH....SNKPK........KIDVEKIKDMVEKEG.....SVILYFDRDNSHKDLLELQDIFESE.GKSFYMREVRYGLSENEYMYEVHIL.
A0A268UAN0_9HELI/1-80             .MELILAKTSI....EEKPQ........KITLEKLAQKLEPNH.....NQLFYFDKENNHKDLLKAVSFFQSK.GRNAYLSEVKFGLDEKDYIYELHIV.
Q0PB54_CAMJE/9-88                 .MELKLARTLI....NEKPK........NISLEKIEEAIEKEG.....QKFFYFDKDNTHKQLIALVNHFEKK.GVSIYHRTVKYGLDDNDFMYEVHIL.
A0A1G3TDQ6_9HELI/1-80             .MDLKFARTDI....TAKPK........KAELAKMEASLEKED.....SVIFYFDRENSHKDLLELQDFFESK.GKSFYMNEVKYGLSDSEYMYQVHII.
A0A2G1DH11_9PROT/1-80             .MELLFARNEL....NEKPK........KVQLEKIKEELLKTG.....EKIFYFDRDNSHKDMMALVDALEEE.GFNVYFREVKYGLADDEYMYEVHAL.
A6DBC5_9PROT/1-76                 .MKLKLVGPNN....EIIEK........--TFEEFIKEIKP--.....NSFYYFHKDTSYKDLKDLIDKLEES.GYSVYFREVKFGLDEGAYMYELHII.
A0A076FAG1_9PROT/1-80             .MELKLARTEL....DNKPK........TISIDKIEAAVSKDG.....GKIFYFDKDNSHKELIALVEYFEQK.GLSVYHRTVKYGLDENDYMYEVHIL.
V8CA71_9HELI/1-90                 .MELKLASMDLgqtlA---KgqakpqttSIVIEDLANEVESKE....gMQILYFDRSCKDKDLKKAKALIEAK.GKTVYMGEVRYGLDSADMIYEFRII.
A0A0C2VTF9_9PROT/1-78             .MKLKLARASV....TSKPK........VIDITKIEDDLDK--.....KSIFYFDKENSHKELKALIEYFEEK.KCSVYMREVKFGLNDDEYIYEVHIV.
A0A1Y1RAQ4_9PROT/1-80             .MELKLAKKEL....KGKSK........TITLEKIEDQLKKEK.....EKIYYFDHDNSHKDLVTLVDHFENE.GYSVYLKEVRYGLDEEDFLYEIHIL.
A7I0Q4_CAMHC/1-80                 .MNLKLARTEI....NAKPA........EISLEKLEEEVKKNG.....QNFFYFDRENSHKDLILLIEAFEKK.GYSVYHRTVKIGLGENEYMYEVHIL.
A0A1P8KQ01_9PROT/1-80             .MELLFARTEL....SEKPK........KVQLDKIKEDLQKDG.....EKIFYFDRDNSHKDMMALVDALEDE.GVNVYFREVKYGLADDEYMYEVHAL.
A0A1B9FCB2_9PROT/1-80             .MELKLARTSI....SAKPK........NIDLETIEDLLKKEG.....QKFFYFDKDNTHKQFIAFINHFKKK.GLSIYHKTVKYGLDDNDFMYEVHIL.
I7HE50_9HELI/1-83                 .MELKLAKNTL....NTKNKtn....avKISCEDILKKLTQ-G.....ENIFYFDKENSHKDMQKACAFFQKA.GHSTYLNEVRYALDEGSYIYELHIL.
A0A128EDU2_CAMFE/1-80             .MELKLARTEL....DKAPK........NIAIEKIEEDLEKSG.....QKIYYFDRENSHKDLIALIEFFEKK.GLSVYHRTVKYGLDDNEYMYEVHIL.
Q7MR24_WOLSU/1-80                 .MDIKLARTEI....EGKPT........KISVEKLEERLEAKG.....QKIFYFDKDNSHKDMMNLIDYFESK.GRSVYFREIRYGLDESDYMYEVHII.
A0A1B1U668_9HELI/1-79             .MDFKLAKSTS....QSAET........TITLKEIQESVKD-Q.....EKFFYFSNENNHKDLLKIVEQFNKS.GRSAYLREAKFGLDEKEYIYELHII.
A0A1W6BVE9_9PROT/1-80             .MDLKLARNLI....NEKPK........NISLEKIEEAVEKEG.....QKFFYFDKENSHKQLIALVEHFEKK.GLNVYHRVVKYGLDENDFIYEVHIL.
D5V755_ARCNC/1-80                 .MELLFARNEL....NEKPK........KVKIDKIVEELKELG.....EKIFYFDKDNSHKDMMALVDGLEGE.GFNVYFREVKYGLAEDEYMYEVHAL.
A0A099VGB3_9HELI/1-84             .MELKLAKESLk..aNIKAD........TITFEDMAKKVEENGk...kGVVFYLDRENAEKDLKKLESFFKGK.NRHTLIRELRYSMDAKDYIYEVHIL.
A0A2D0I8N2_9HELI/1-80             .MELKLARSEQ....DTKPR........KIDLKKITEMVEKSN.....SSILYFDRENSHKDLLALQDHFEAE.GKSFYMREVKYGLSANEYMYEVHIL.
A0A268T8T2_9HELI/1-80             .MELILAKTKL....EDKTQ........KITLEKLAEKLNPEY.....NHMIYFDKSNNHKDLLKVVSFFQNK.GKSAYLSEVKFGLDEKDYIYELHII.
E7AD74_HELFC/1-82                 .MELQLARQSL....KDDAK........KMPKLPLEDIIKKHEh...gECVFYFAGSNPHKDMLAMLASLEKK.GYRVCLFEVKISTDAKDFLYALHFI.
A0A071LC11_9PROT/1-80             .MELKLARSEL....NAKPK........AISLDKIEQSVSKEG.....QKIFYFDKENSHKQLIALVEFFEEK.GLSVYHRVVKYGLDENDYMYEVHIL.
A0A1I5P9B2_9PROT/1-80             .MELKAVRTEL....NAKPK........TISLEKIEKEIEKEG.....QKIFYFDRENSHKDLMEMVEYFESK.GLSVYFKEVRYGLDENDYLYEAHIL.
A0A258X3H3_9PROT/1-80             .MELKVARNDT....DAKPK........KIDLKKMTEMVEKSN.....SLIFYFDRENSHKDLLALQDHFEGI.GKSFYMREVRFGLSANEYMYEVHIL.
A0A099V6Q3_9HELI/1-84             .MELKLAKESLk..aDIKAN........TITFEAMAKKVEESGs...kGAIFYLDRENAEKDLKKLESFFKGK.NHHTLIRELRYSMDTKDYIYEVHIL.
A0A0B0Q8A1_9PROT/1-80             .MEIKLARNEI....NGKPK........TITLEKVAEIIEKEG.....QKIFYFDKENSHKDLVALVEHFEAK.GLSVYLRDIRYGLGEGDYMYEVHIL.
A0A1B8J8P6_9HELI/1-87             .MELKLAPMDLg..qTAQKQ........TIKVESLLEKPDTKSkapssIQIVYFDKTNSNKDLQKAKALLESK.GKVVYMNEVRYGLDAKDFIYEFRII.
A0A1V9VA19_9PROT/1-80             .MELLIARNEL....NEKPK........KVQLEKIKDELKKEG.....QKIFYFDRDNSHKDMMALVEALEKE.GFNIYFREIKFGLADDEYMYEVHAL.
A0RQN6_CAMFF/1-80                 .MELKLARTEL....DNKPK........TISLDKIEAAIGKDG.....GKIFYFDKDNSHKELIALVEYFEER.GLSVYHRTVRYGLDENDYMYEVHIL.
A0A268TSZ1_9HELI/1-80             .MELTLARGNM....EEKPQ........KISLEKLFEKLEAGG.....DKVFYFDRANNHKDLLKAVNFFEGK.GRKAYLSEIKISLDEKDYIYELHII.
A0A0A8H330_9PROT/1-80             .MDLKIARTSI....DEKPK........SISIENIEKAIEKEG.....QKFFYFDKDNAHKQLIALVEHFEKK.GKCVYHRTIRYGLDEADYMYEVHIL.
J0LDF2_9HELI/1-81                 .MEFKLARESL....DSQPE........VVNLDYIEKQAEKED.....ETIIYLDRTNSQKVLNQLEKHFDKNfEKNVYRREVKFGLDENDYLYEVHIL.
B6BIG3_SULGG/1-80                 .MDLKFARTDI....DTKPK........KADLEKIEASVEKEG.....SVIFYFDRENSHKDLLELQDYFEEK.GKSFYLSEVKFGLSDNEYMYQVHII.
A0A268TJ09_9HELI/1-80             .MELVLAKTNL....EEKAQ........KISLEKLAEKLQADN.....NRVFYFDPSNSHKDLLKAVSFFENK.GRKAYLSEIKISLDEKDYIYELHII.
A0A091AH50_9HELI/1-80             .MELKIARSEH....DAKPK........KIDLKKITEMVEKTN.....SLMLYFDRENSHKDLLALQDHFEGE.GKSFYMREVRYGLSANEYMYEVHIL.
D1AZJ8_SULD5/1-80                 .MEIKLARNEI....NGKPK........TITLEKITEIIEKEG.....QKIFYFDKENSHKDLVALVETFETK.GFSVYLRDIKYGLGEGDYMYEVHIL.
C5ZVX2_9HELI/1-80                 .MDIKLVREHI....NEKPQ........KVTIKKLEEMLETKK.....MDIFYCDKENSHKDMMALMDYFEKK.GKHVYFREVKYGLDEGDYMYEFHIL.
B9D4P2_CAMRE/1-80                 .MELKLARTQL....DAKPK........TISLEKIEAAFTKDP.....QQIFYFDRENSHKQLIALVEFFEEK.GLSVYHRTVRYGLNENDYMYEVHIL.
I2K5Y4_9PROT/1-78                 .MKLKLARTTL....KAKPK........TIELQKIEDELAN--.....RSIFYFDKDNSHKELKELIEYFEEK.GFSVYMREVKYGLDDNEYIYEVHII.
A0A1S6U8F4_9PROT/1-80             .MELKLARSEL....SSKPK........TISLDKIEAAVSKEG.....QKIFYFDKDNSHKQLIELVEFFEEK.GLSVYHRVVKYGLDDKDYMYEVHIL.
A0A0M5MG19_9PROT/1-80             .MELKLARAEL....DAKPK........TISLEKIEAAVEKEG.....QKIFYFDKENTHKQLIALVEHFEEK.GLSVYHRTVKYGLDDSDYMYEVHIL.
F8KRG3_HELBC/1-81                 .MELRLARSDR...kQSKSH........TISLEDLHQKYLKHK.....EHIFYFAPSNTHKDMLGAVGFFAKK.GCKAYLSEVQISTDDKDFIYQLHII.
A0A099TYG1_9HELI/1-84             .MEIKVAKNSLk..sDASQS........ILTLEDMLSIVNENGk...rGAIFYLDRENPEKNIKKIETFFKGK.DHATIIREVRISMDEKDYIYEIHVL.
T0JSB7_9HELI/1-80                 .MDLKFARTDI....ETKPK........KVDLDKLEASVEKEG.....SMIFYFDKENSHKDLLELQDHFEQK.GKSFYMSEVKYGLSDGEYMYQVHII.
C8PFL0_9PROT/1-80                 .MQLKLARTEL....ASKPK........SVKIEDLQAQVEKSG.....QKIFYLDRENSQKDLAALVDFFDTK.GFSVYQRIVRYGLNENEYMYEVHIL.
A0A099TUI7_9HELI/1-80             .MDIKLARTHI....NEKPA........KITVKKLEEMLEEKK.....SDIFYCDKENSHKDMQALLEYFEKK.GKRAYFREVRYGLDEGDYMYEIHVL.
A0A1Y0HJZ8_9PROT/1-80             .MEIKLARNEI....NGKPK........TITLEKVTEIIEKEG.....QKIFYFDKENSHKDLVSLVEHFEAQ.GFSVYLRDIRYGLGESDYMYEVHIL.
A0A2A2GU85_9HELI/1-82             .MELKVAKTDL....QSKKNe......vKISLDEVLRQYKEEN.....RHVFYFDGQNAHKDMQKAQNTIQKA.GYRVQLNEVRYGLDENNYIYEIHII.
A6Q532_NITSB/1-80                 .MELKLARQEL....SGKPK........TISVEKIEEAVQKEG.....NKIFYFDRENSHKDLVELVEHFEEK.GYSVYFREVKYGLDENDYIYEVHIL.
Q30PR0_SULDN/1-80                 .MDLKFARTDV....TAKPK........KAELAKIEAAVEKDE.....SVIFYFDKENSHKDLLELQDYFEAK.GKSFYMNEVKYGLSDGEYMYQVHII.
A8ERE8_ARCB4/1-80                 .MELLLARNEL....NEKPK........KVQLDKIKEDLEKDG.....QKIFYFDKDNSHKDMMALVSALEKN.GLNVYFREVRYGLADDEYMYEVHAL.
A0A1G3UE22_9HELI/1-80             .MDLKFARTDI....NAKPK........KVELAKIEATLEKEE.....SVIFYFDRENSHKDLLELQDYFEAK.GKSFYMSEVKYGLSDSEYMYQVHII.
A0A099UC78_9HELI/1-80             .MDIKLAREHI....NQKPV........KIAIKKLEEMLEAKK.....TDIFYCDKENSHKEITNLIEYFAKK.GKHAYCREVRYGLDEGDYMYEIHIM.
A0A1C0B8D5_9PROT/1-80             .MELLLARNEL....KEKPK........KLHLDKIKEELKKDS.....QKIFYFDRDNSHKDMMSLVEALEKE.GYNIYFREIKYGLADDEYMYEVHAL.
A0A087MD64_9PROT/1-80             .MEIKLARNEI....NGKPK........TITLDKVTEIIEKEG.....QKIFYFDKENSHKDLVALVEHFEAQ.GFSVYLRDIRYGLGESDYMYEVHIL.
E7G5A2_9HELI/1-80                 .MELRLAKMDR...kQSKLY........SISLEELYQKALK-K.....EHIFYFAPTNSHKDMLQAVAFLEKQ.NCRVHLSEVQVSSDEKDFIYQLHII.
E0UPC4_SULAO/1-80                 .MDLKFARTDL....DAKPK........KADLAKLDAEVAKND.....SIIFYFDRENSHKDLLELQDHYEAM.GKSFYMSEVKYGLSDNDYMYQVHIM.
A6QCD1_SULNB/1-78                 .MKLKLARTTL....KAKPK........TIELKKLEEELAN--.....RSIFYFDKDNSHKELKELIEYFEEK.GYSVYMREVKYGLDDNEFIYEVHII.
H5VEW1_HELBI/1-81                 .MELRLARSDR...kQSKSH........TISLEDLHQKYLKHK.....EHIFYFAPSNTHKDMLGAVDFFAKK.GCKAYLSEVQISTDDKDFIYQLHII.
G2HSU5_9PROT/1-80                 .MELLFARNEL....NEKPK........KVQLDKIKEELNKDG.....QKIFYFDRDNSHKDMMALVDALEAD.GNNVYFREVKYGLADDEYMYEVHAL.
A7GZE0_CAMC5/1-80                 .MELKLARTEI....DAKPK........TISLDKIEAAVSKEG.....QKIFYFDKENSHKQLIALVEFFEEK.GLSVYHRTVRYGLDDNDYMYEVHIL.
T1CN70_9HELI/1-82                 .MELKLATMDI....GQTPK........KITLDGLYEQISSTNk...dSIFYYFDRENSHKELQKAKTFLESK.GKKVYIDEVHYGLDPKDFIYEFHIV.
I0ERC6_HELCM/1-80                 .MKLVLAKNTR....KSEQK........SVELEDLYKKFSEER.....RSIFYFAPTNAHKDMLKAVDFFKEK.GHTAYLDEVRVSTDEKDFLYELHII.
A0A099VWP5_9HELI/1-80             .MDIKLAREHI....NEKPM........KVTIKKLEEMLEDKN.....TDIFYCDKENSHKEMQSLLEYFEKK.GKRAYFREVRYGLDEGDYMYEMHIL.
A0A0K2Y3V6_9HELI/1-80             .MELRLAKMDR...kQSKTP........SLSLEELHQKYLK-N.....EHIFYFAPTNAHKDMLAAVAFLEKK.HCRVHLSEVQISSDEKDFIYQMHII.
B9KF50_CAMLR/30-109               .MDLKIARTSV....DEKPK........SISLESIEKAVDKEG.....QKFFYFDKDNAHKQLIALVEHFEKK.GKCVYHRTIKYGLDDTDFMYEVHIL.
A0A1X9STV5_9PROT/1-80             .MELKLARAEL....DAKPK........TISLEKIESAALKDG.....GKIFYFDRDNSHKQLIALVEHFENK.GLSVYHRTVKYGLDENDYMYEVHIL.
E6WZ14_NITSE/1-78                 .MKLKLARTTL....KAKPK........SVELSKIEEMLPQ--.....KSIFYFDRDNSHKDLKALIEHFEEE.GYNVYMREVKYGLNEDEYIYEVHIV.
A0A1G3TLZ6_9HELI/1-80             .MDLKFARTDI....TAKPK........KAELAKIEASLEKDD.....SVIFYFDRENSHKDLLELQDYFEAK.GKSFYMNEVKYGLADSEYMYQVHII.
A0A268TQ87_9HELI/1-80             .MELTLAKTNL....EQKAQ........KISLEKLAEKLKSDH.....DQVFYFDRSTNHKDLLKAVSFFENK.GRKAYLSEIKISLDEKDYIYELHII.
K7SAZ0_9HELI/1-80                 .MELKLARSEH....DTKPR........KIDLKKITEMVEKSN.....SSILYFDRENSHKDLLALQDHFEGE.GKSFYMREVKFGLSANEYMYEVHIL.
E6L964_CAMUP/1-80                 .MDLKLARNLI....NDKPK........NISLSKIEDAVEKEG.....QKFFYFDKENSHKQLIALVEHFEKK.GLNVYHRIIRYGLDEQDYMYEVHIL.
A0A2G2CTP1_9HELI/1-80             .MDLKFARTEI....NDKPK........KVDLAKIEASVEKDD.....SIIFYFDKDNSHKDLLALQDHFEAK.GKSFYMSEVKFGMSDNDYMYQVHIM.
B9L7T4_NAUPA/1-76                 .MTLKLISTDN....NIIEK........--TYEEFLKEIKP--.....NSFFYFHKDTSYKDLKDLIDKLEND.GYSVYFREVKFGLDEGAYMYELHII.
O25047_HELPY/1-80                 .MKLVLAKNTR....KSDAK........SVELEDLYHEFSEDK.....RSIFYFAPTNAHKDMLKAVDFFKEK.GHTAYLDEVRVSTDEKDFLYELHII.
#=GR O25047_HELPY/1-80      SS    .SSEEE-TTTT....-SS-T........THHHHHHHHHHHH-S.....EEEEEE--TTTSHHHHHHHHHHHHS.TT-EEEEE-TTTTTT--EEEEEE--.
A0A268U0H7_9HELI/1-80             .MELTLAKTDF....EQKTQ........KINLEKLLKNIGNDH.....DKVFYFDRSNNHKDLLKAVSFFENK.GKKAYLSEIKYGLDEKDYIYELHII.
A0A099TF83_9HELI/1-84             .MELKLAKQSL...nNAKSKas....htKMTLEEILNKAQE-G.....QHIFYFDKENTHKDMQKAKTFFEKA.KHSVHLNEVRYGLDESSYIYELHII.
A0A268U5L9_9HELI/1-81             .MDLKLAKMDL....KQDCK........ISSLADILKIANEHK....rGKIFYLDKDNSEKDLKKAISTFTSK.GKTCFLREIKYGLDEKDYIYELHLL.
A0A099VUG2_9HELI/1-84             .MELKLAKQSL...nNAKSKas....htKMTLEEILNKAQE-G.....QHIFYFDKENTHKDMQKAKTFFEKA.KHSVHLNEVRYGLDESSYIYELHII.
#=GC SS_cons                      .SSEEE-TTTT....-SS-T........THHHHHHHHHHHH-S.....EEEEEE--TTTSHHHHHHHHHHHHS.TT-EEEEE-TTTTTT--EEEEEE--.
#=GC seq_cons                     .MELKLARscl....ssKPK........pIsL-Klpcplpccs.....ppIFYFD+-NSHKDLhtLl-aFEpK.GhslYhREV+YGLD-s-YhYEVHIl.
//
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