GenomeNet

Database: Pfam
Entry: HTH_53
LinkDB: HTH_53
Original site: HTH_53 
#=GF ID   HTH_53
#=GF AC   PF18606.1
#=GF DE   Zap  helix turn helix N-terminal domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF07889
#=GF GA   30.60 30.60;
#=GF TC   31.30 30.80;
#=GF NC   28.10 30.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   22407013
#=GF RT   Structure of N-terminal domain of ZAP indicates how a
#=GF RT   zinc-finger protein recognizes complex RNA.
#=GF RA   Chen S, Xu Y, Zhang K, Wang X, Sun J, Gao G, Liu Y;
#=GF RL   Nat Struct Mol Biol. 2012;19:430-435.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Zinc-finger antiviral protein (ZAP) is a host factor that
#=GF CC   specifically inhibits the replication of certain viruses, such
#=GF CC   as HIV-1, by targeting viral mRNA for degradation. This domain
#=GF CC   is a helix turn helix domain found at the N-terminal region
#=GF CC   constituting the top cockpit layer of the protein [1].
#=GF SQ   98
#=GS G3QEF0_GORGO/5-66      AC G3QEF0.2
#=GS A0A1D5PEY4_CHICK/5-66  AC A0A1D5PEY4.1
#=GS G3TCA8_LOXAF/5-66      AC G3TCA8.1
#=GS ZCCHV_MOUSE/5-66       AC Q3UPF5.1
#=GS A0A091E4X4_FUKDA/5-66  AC A0A091E4X4.1
#=GS F7HRZ4_MACMU/5-66      AC F7HRZ4.1
#=GS ZCCHL_HUMAN/5-66       AC Q96H79.2
#=GS A0A0D9R8G3_CHLSB/5-66  AC A0A0D9R8G3.1
#=GS A0A218UQM8_9PASE/5-66  AC A0A218UQM8.1
#=GS G1RUS2_NOMLE/5-66      AC G1RUS2.2
#=GS G5B553_HETGA/5-66      AC G5B553.1
#=GS A0A2K5NBW3_CERAT/5-66  AC A0A2K5NBW3.1
#=GS M3XXH4_MUSPF/5-66      AC M3XXH4.1
#=GS J9P1L5_CANLF/5-66      AC J9P1L5.1
#=GS M3X2R1_FELCA/5-66      AC M3X2R1.1
#=GS H0VAQ6_CAVPO/5-66      AC H0VAQ6.2
#=GS H0ZNG7_TAEGU/5-66      AC H0ZNG7.1
#=GS F7EF40_CALJA/5-66      AC F7EF40.1
#=GS K7FWN3_PELSI/5-64      AC K7FWN3.1
#=GS A0A096MUZ7_PAPAN/5-66  AC A0A096MUZ7.2
#=GS I3M6F9_ICTTR/5-66      AC I3M6F9.2
#=GS A0A2I3GRR6_NOMLE/5-66  AC A0A2I3GRR6.1
#=GS A0A1U7T816_TARSY/5-63  AC A0A1U7T816.1
#=GS W5PN22_SHEEP/5-66      AC W5PN22.1
#=GS G5B552_HETGA/5-68      AC G5B552.1
#=GS A0A287B525_PIG/5-66    AC A0A287B525.1
#=GS A0A2I3G343_NOMLE/5-66  AC A0A2I3G343.1
#=GS F7EF16_CALJA/5-65      AC F7EF16.1
#=GS F1NWL9_CHICK/5-66      AC F1NWL9.3
#=GS A0A0D9R833_CHLSB/5-66  AC A0A0D9R833.1
#=GS F7HRZ0_MACMU/5-66      AC F7HRZ0.2
#=GS G3X9X5_MOUSE/5-66      AC G3X9X5.1
#=GS H0WVR8_OTOGA/5-68      AC H0WVR8.1
#=GS ZCCHV_RAT/5-66         AC Q8K3Y6.1
#=GS ZCCHV_RAT/5-66         DR PDB; 3U9G A; 5-66;
#=GS G1MHV7_AILME/5-66      AC G1MHV7.1
#=GS H2R0U7_PANTR/5-66      AC H2R0U7.2
#=GS G1TEP1_RABIT/5-66      AC G1TEP1.1
#=GS A0A2G9SIR9_LITCT/5-44  AC A0A2G9SIR9.1
#=GS A0A1S3WDZ9_ERIEU/5-66  AC A0A1S3WDZ9.1
#=GS A0A2K5MAY9_CERAT/5-66  AC A0A2K5MAY9.1
#=GS F6Q069_ORNAN/35-95     AC F6Q069.2
#=GS A0A0Q3MR78_AMAAE/5-65  AC A0A0Q3MR78.1
#=GS A0A2G9QL57_LITCT/5-46  AC A0A2G9QL57.1
#=GS H2PNN2_PONAB/5-66      AC H2PNN2.2
#=GS M7C268_CHEMY/5-64      AC M7C268.1
#=GS A0A288CG04_PIG/5-66    AC A0A288CG04.1
#=GS A0A2I3GER7_NOMLE/5-66  AC A0A2I3GER7.1
#=GS A0A1S3FLW0_DIPOR/5-66  AC A0A1S3FLW0.1
#=GS F6TWC3_MONDO/5-64      AC F6TWC3.1
#=GS G3TCB5_LOXAF/1-39      AC G3TCB5.1
#=GS ZCCHL_MOUSE/5-68       AC Q8BFR1.1
#=GS A0A287BCI1_PIG/5-68    AC A0A287BCI1.1
#=GS F6V7E9_CANLF/5-66      AC F6V7E9.1
#=GS A0A1S2ZVG4_ERIEU/5-61  AC A0A1S2ZVG4.1
#=GS H2PNN1_PONAB/5-66      AC H2PNN1.1
#=GS A0A096NY80_PAPAN/5-66  AC A0A096NY80.1
#=GS A0A151P7N4_ALLMI/5-64  AC A0A151P7N4.1
#=GS A0A226NDY3_CALSU/5-67  AC A0A226NDY3.1
#=GS L5KSM3_PTEAL/5-66      AC L5KSM3.1
#=GS A0A1S3FKM8_DIPOR/5-66  AC A0A1S3FKM8.1
#=GS A0A1A6HKL5_NEOLE/5-66  AC A0A1A6HKL5.1
#=GS A0A1U7S9V6_ALLSI/5-64  AC A0A1U7S9V6.1
#=GS G1KD35_ANOCA/5-63      AC G1KD35.1
#=GS A0A1S3FMN4_DIPOR/5-66  AC A0A1S3FMN4.1
#=GS G1NM58_MELGA/5-67      AC G1NM58.1
#=GS U3KN58_RABIT/5-66      AC U3KN58.1
#=GS F7F0B1_RAT/5-66        AC F7F0B1.1
#=GS A0A2G9SIL3_LITCT/5-44  AC A0A2G9SIL3.1
#=GS F7F3K5_MONDO/5-67      AC F7F3K5.1
#=GS G7P0X7_MACFA/5-66      AC G7P0X7.1
#=GS D3Z5I1_MOUSE/5-66      AC D3Z5I1.1
#=GS G3RLS1_GORGO/5-66      AC G3RLS1.2
#=GS K7FWI1_PELSI/5-64      AC K7FWI1.1
#=GS A0A1U8CE90_MESAU/5-66  AC A0A1U8CE90.1
#=GS F7EJ32_CALJA/5-66      AC F7EJ32.1
#=GS L9L233_TUPCH/5-66      AC L9L233.1
#=GS A0A091IN00_CALAN/5-67  AC A0A091IN00.1
#=GS H2QVG6_PANTR/5-66      AC H2QVG6.1
#=GS G1PJP6_MYOLU/5-65      AC G1PJP6.1
#=GS A0A286XXV9_CAVPO/1-48  AC A0A286XXV9.1
#=GS G3HH79_CRIGR/5-66      AC G3HH79.1
#=GS A0A2K5IBH0_COLAP/5-66  AC A0A2K5IBH0.1
#=GS E1BCF8_BOVIN/5-66      AC E1BCF8.1
#=GS ZCCHV_HUMAN/5-66       AC Q7Z2W4.3
#=GS H0X2S8_OTOGA/5-66      AC H0X2S8.1
#=GS E1BM10_BOVIN/5-68      AC E1BM10.2
#=GS R4GB36_ANOCA/5-66      AC R4GB36.1
#=GS D3ZIC9_RAT/5-68        AC D3ZIC9.1
#=GS L5KPW3_PTEAL/60-121    AC L5KPW3.1
#=GS A0A1U8CGX7_MESAU/5-66  AC A0A1U8CGX7.1
#=GS C9J6P4_HUMAN/5-66      AC C9J6P4.1
#=GS A0A1V4K8B5_PATFA/5-67  AC A0A1V4K8B5.1
#=GS F7GNE1_CALJA/5-66      AC F7GNE1.1
#=GS W5PME6_SHEEP/5-67      AC W5PME6.1
#=GS A0A226PLL7_COLVI/5-66  AC A0A226PLL7.1
#=GS F7EF06_CALJA/5-65      AC F7EF06.1
#=GS A0A2K5H6M4_COLAP/5-66  AC A0A2K5H6M4.1
#=GS F6S442_HORSE/5-66      AC F6S442.1
G3QEF0_GORGO/5-66                 .EVCCFITKILC.AHGGRMALDALLQEIALSEPQLCEVLQVAGPDRFVVLETGGEAG..ITRSVVA...........
A0A1D5PEY4_CHICK/5-66             v-VCSFLTKTLC.AEGGRLGLAELQQHVGLSAQQLRETLQAAGPERFLLLTGAGGAP..-------evlalta....
G3TCA8_LOXAF/5-66                 .TLCSFLTKVLC.AHGGRMFLRDLRAHVELSEAQLRAVLRAAGPERFLLQDVAGPEG..LLLQDVA...........
ZCCHV_MOUSE/5-66                  .EVFCFITKILC.AHGGRMTLEELLGEISLPEAQLYELLKAAGPDRFVLLETGDQAG..ITRSVVA...........
A0A091E4X4_FUKDA/5-66             .TVCCFITKILC.AHGGRLSLDALLEKIELSEAQLLDVLKEAGPDRFVVLETGGRAG..VTRSVVA...........
F7HRZ4_MACMU/5-66                 .TVCSFLTKVLC.AHGGRMFLRDLRGHVELSEARLRDVLQRAGPERFLLQEVETQEG..L------gdaeae.....
ZCCHL_HUMAN/5-66                  .TVCSFLTKVLC.AHGGRMFLKDLRGHVELSEARLRDVLQRAGPERFLLQEVETQEG..L------gdaeae.....
A0A0D9R8G3_CHLSB/5-66             .TVCSFLTKVLC.AHGGRMFLRDLRGHVELSEARLRDVLQRAGPERFLLQEVETQEG..L------gdaeae.....
A0A218UQM8_9PASE/5-66             .AVFSFLTQTLC.AHGGRLGLRELQEHIGLPALQLQDTLAAAGPRRFVLLEGGQA--..-------vlavtdarv..
G1RUS2_NOMLE/5-66                 .EVCCFITKILC.AHGGRMALDALLQKIALSELQLCEVLQVAGPDRFVVLETRGEAG..ITRSVVA...........
G5B553_HETGA/5-66                 .TVCCFVTKILC.AHGGRLSLDALLEKIELSEAQLLEVLKEAGPDRFVVLETGGRAG..VTRSVVA...........
A0A2K5NBW3_CERAT/5-66             .EVCCFITKILC.AHGGRMALDALLEEIALFEPQLCEVLQVAGPDRFVVLETSGEAG..ITRSVVA...........
M3XXH4_MUSPF/5-66                 .EVCCFITKVLC.AHGGRMALDALLEEIRLPEGQLLEVLEEAGPDRFVLLETGGREG..ITRSVVA...........
J9P1L5_CANLF/5-66                 .EVCCFITKILC.AHGGRMALDALLQEIALSEAQLREVLEAAGPDRFVLLETGDRAG..VTRAVVA...........
M3X2R1_FELCA/5-66                 .EVCCFITKILC.AHGGRMALDALLEKIALTEAQLREVLEAAGPDRFVLLETGDRAR..VTGFVVA...........
H0VAQ6_CAVPO/5-66                 .TVCCFITKILC.AHGGRLSLDALLEKIQLSEAQLLEVLKEAGPDRFVVLETGGRAG..VTRSVVA...........
H0ZNG7_TAEGU/5-66                 .AVCSFLTQTLC.AHGGRLGLRELQEHIGLPALQLQHTLAAAGPRRFVLLEGGRE--..-------vlavtdarv..
F7EF40_CALJA/5-66                 .TVCSFLTKVLC.AHGGRMFLRDLRGHVELSEARLQDVLQRAGPERFLLQEVETQEG..L------gdpeaa.....
K7FWN3_PELSI/5-64                 .AVCSFITKVLC.SSGGRLEFSQIPQHVGLPEPQLEQILRDVGHERFLVHMQGGC--..-------rwvlavs....
A0A096MUZ7_PAPAN/5-66             .TVCSFLTKVLC.AHGGRMFLRDLRGHVELSEARLRDVLQRAGPERFLLQEVETQEG..L------gdaeae.....
I3M6F9_ICTTR/5-66                 .TVCSFLTKVLC.ANGGRMFLQDLRGHVELSEAKLRDVLQRAGPERFLLQEVEMKEG..LW-----daeae......
A0A2I3GRR6_NOMLE/5-66             .EVCCFITKILC.AHGGRMALDALLQKIALSELQLCEVLQVAGPDRFVVLETRGEAG..ITRSVVA...........
A0A1U7T816_TARSY/5-63             .TVCSFLTKVLC.AHGGRMFLPDLRGHVELSEAKLQDVLRRAGPDRFLLQEVAAR--..-------edpgda.....
W5PN22_SHEEP/5-66                 .GVCSFITKILC.AHGGRMALEALLREMQLSEAQLCEVLEEAGPDRFVVLPGSGREG..LTGNRI-s..........
G5B552_HETGA/5-68                 .TVCSFLTKVLC.AHGGRMLLQDLRGHVELSPARLGDLLQRAGPERFLLQDVEVEAGgaRACRVVA...........
A0A287B525_PIG/5-66               .GVCCFITKILC.THGGRMALEELLQKVKLSEAQLCEVLTTAGPDRFVLLETGGKAG..VTRSVVA...........
A0A2I3G343_NOMLE/5-66             .TVCSFLTKVLC.AHGGRMFLRDLRGHVELSEARLRDVLQRAGPERFLLQEVETQEG..L------gdaeae.....
F7EF16_CALJA/5-65                 .TVCSFLTKVLC.AHGGRMFLRDLRGHVELSEARLQDVLQRAGPERFLLQEVETQEG..L------gdpea......
F1NWL9_CHICK/5-66                 v-VCSFLTKTLC.AEGGRLGLAELQQHVGLSAQQLRETLQAAGPERFLLLTGAGGAP..-------evlalta....
A0A0D9R833_CHLSB/5-66             .EVCCFITKILC.AHGGRMALDALLEEIALSEPQLREVLQVAGPDRFVVLETSGEAG..ITRSVVA...........
F7HRZ0_MACMU/5-66                 .EVCCFITKILC.AHGGRMALDALLEEIALSEPQLCEVLQVAGPDRFVVLETSGEAG..ITRSVVA...........
G3X9X5_MOUSE/5-66                 .EVFCFITKILC.AHGGRMTLEELLGEISLPEAQLYELLKAAGPDRFVLLETGDQAG..ITRSVVA...........
H0WVR8_OTOGA/5-68                 .TVCSFLTKVLC.ANGGRMFLQDLRGHVELSEAKLRDVLQRAGPDRFLLQEVEMKEG..LW-----daeaeva....
ZCCHV_RAT/5-66                    .GVCCFITKILC.AHGGRMTLEELLGEIRLPEAQLYELLETAGPDRFVLLETGGQAG..ITRSVVA...........
#=GR ZCCHV_RAT/5-66         SS    .----HHHHHHH.HTTTEEEHHHHHHHHT--HHHHHHHHHHH-TTTEEEEE------..--EEEEE...........
G1MHV7_AILME/5-66                 .EVCCFITKILC.AHGGRMALDALLKEIALSEGQLREVLEAAGPDRFVLLETGDREG..VTRSVVA...........
H2R0U7_PANTR/5-66                 .EVCCFITKILC.AHGGRMALDALLQKIALSERQLCEVLQVAGPDRFVVLETGGEAG..ITRSVVA...........
G1TEP1_RABIT/5-66                 .GVCCFITKILC.AHGGRLALDALLQEIGLPKAQLCHELEAAGLERFVVLETGGKDG..VSCSVVA...........
A0A2G9SIR9_LITCT/5-44             a-VTAYLTKLLC.SHGGRLERDQLRELLDLPAEQIEQILQ-----------------..-------de.........
A0A1S3WDZ9_ERIEU/5-66             v-VCSYITKVLC.AHGGRLALGELLEQILLSEEQLLQVLEAAGRERFVLLDSGGRAG..LARHVVA...........
A0A2K5MAY9_CERAT/5-66             .TVCSFLTKVLC.AHGGRMFLRDLRGHVELSEARLRDVLQRAGPERFLLQEVETQEG..L------gdaeae.....
F6Q069_ORNAN/35-95                v-VCTFLTKLLC.EHGGRMPRQDLPRHIALPDPQLDQVLREAGPDRFVLAGDG-PGG..-------vevvavs....
A0A0Q3MR78_AMAAE/5-65             s-VCSFLTKTLC.AHGGRLALGDLQQLVGLSAQQLEQTLSAVGPQRFLVQRDGGG--..-------vwvlavsa...
A0A2G9QL57_LITCT/5-46             .TVTAYLTKLLC.SHSGRLERNQLDNLLDLSAQQTEQILQE----------------..-------ell........
H2PNN2_PONAB/5-66                 .EVCCFITKILC.AHGGRMALDALLQEIVLPEPQLCEVLQVAGPDRFVVLETGGEAG..ITRSVVA...........
M7C268_CHEMY/5-64                 .AVCSFITKVLC.SNGGRLEYSKISQHVELSEQQLEQILQDVGQERFLVHKEGGSRW..V------lavs.......
A0A288CG04_PIG/5-66               .GVCCFITKILC.THGGRMALEELLQKVKLSEAQLCEVLTTAGPDRFVLLETGGKAG..VTRSVVA...........
A0A2I3GER7_NOMLE/5-66             .EVCCFITKILC.AHGGRMALDALLQKIALSELQLCEVLQVAGPDRFVVLETRGEAG..ITRSVVA...........
A0A1S3FLW0_DIPOR/5-66             .TVCSFLSKVLC.AHGGRMLLRDLRGHVELSEAQLRAVLLRAGPERFLLQAFS----..-------ppgpthksica
F6TWC3_MONDO/5-64                 .TVCDFLTRILC.AHGGRMELRELLGHIELSETQVVEVLSEAGPERFMLLDQG--PG..TCPVVL-a..........
G3TCB5_LOXAF/1-39                 .-----------.-------------KIALSEEQLCEVLEAAGPDRFVVQETEGRWV..VA-----ttrarv.....
ZCCHL_MOUSE/5-68                  .TLCAFLTKVLC.AHGGRMFLQDLRGHVELSEAKLRAVLRRAGPERFLLQEVELRDG..-------pwdaeaeva..
A0A287BCI1_PIG/5-68               .TVCSFLTKVLC.AHGGRMFLQDLRGHVELSEARLRDVLRQAGPDRFLLQEVEVREG..P------grrrrsla...
F6V7E9_CANLF/5-66                 .EVCCFITKILC.AHGGRMALDALLQEIALSEAQLREVLEAAGPDRFVLLETGDRAG..VTRAVVA...........
A0A1S2ZVG4_ERIEU/5-61             .TLCAFLTKLLC.AHGGRLLLPALRAHVELPEARLRAVLLQAGPGRFLLHDV-----..-------apgplsp....
H2PNN1_PONAB/5-66                 .TVCSFLTKVLC.AHGGRMFLKDLRGHVELSEARLRDVLQRAGPERFLLQEVETQEG..L------gdaeae.....
A0A096NY80_PAPAN/5-66             .EVCCFITKILC.AHGGRMALDALLEEIALSEPQLCEVLQVAGPDRFVVLETSGEAG..ITRSVVA...........
A0A151P7N4_ALLMI/5-64             d-VWPFLTKTLC.AHGGSLDLRELPQHVELPESQLGRIVRDAGPGRFLLQQAGGTCQ..V------lavt.......
A0A226NDY3_CALSU/5-67             v-VCNFLTKTLC.ANGGRLGLAELQQHVGLSAKQLHDTLQAAGPQRFLLMGAGGEPE..VL-----alstvr.....
L5KSM3_PTEAL/5-66                 .EVCCFITKILC.AHGGRMALDALLDEIALSKAQLCEVLQAAGPNRFAVLETRDGAG..VTRSVVA...........
A0A1S3FKM8_DIPOR/5-66             .EVCSFIVKVLC.AHGGRMTLDALLEEIALSQGQLRQVLEDAGPDRFVLLQTRSSTG..STWSVVA...........
A0A1A6HKL5_NEOLE/5-66             .TVCAFLTKVLC.AHGGRMFLQDLRGHVELSEAKLRAVLRRAGPERFLLQEVELRDG..-------pwdpeae....
A0A1U7S9V6_ALLSI/5-64             d-VWPFLTKTLC.AHGGSLDLRELPQHVELPESQLGRIVGDAGPGRFLLQQAGGTCQ..V------lavt.......
G1KD35_ANOCA/5-63                 v-VCSFITKILC.SMGGSSSYQEILPLLGLPDHQLRQILEESGKERFLVNEQGTS--..-------lqvlai.....
A0A1S3FMN4_DIPOR/5-66             .EVCSFIVKVLC.AHGGRMTLDALLEEIALSQGQLRQVLEDAGPDRFVLLQTRSSTG..STWSVVA...........
G1NM58_MELGA/5-67                 v-VCSYLTETLC.AKGGRLGLAELQQYVGLSAQQLQETLQAAGPERFLLLTGSGEAP..E------vlaltav....
U3KN58_RABIT/5-66                 .GVCCFITKILC.AHGGRLALDALLQEIGLPKAQLCHELEAAGLERFVVLETGGKDG..VSCSVVA...........
F7F0B1_RAT/5-66                   .GVCCFITKILC.AHGGRMTLEELLGEIRLPEAQLYELLETAGPDRFVLLETGGQAG..ITRSVVA...........
A0A2G9SIL3_LITCT/5-44             a-VTAYLTKLLC.SHGGRLERDQLRELLDLPAEQIEQILQ-----------------..-------de.........
F7F3K5_MONDO/5-67                 .GVCCFLTKLLCeNKSGSSDVQRLSQKIGWSEAQLSQILQEAGPERFLLVEDEDPSV..A------vavavs.....
G7P0X7_MACFA/5-66                 .EVCCFITKILC.AHGGRMALDALLEEIALSEPQLCEVLQVAGPDRFVVLETSGEAG..ITRSVVA...........
D3Z5I1_MOUSE/5-66                 .EVFCFITKILC.AHGGRMTLEELLGEISLPEAQLYELLKAAGPDRFVLLETGDQAG..ITRSVVA...........
G3RLS1_GORGO/5-66                 .TVCSFLTKVLC.AHGGRMFLKDLRGHVELSEARLRDVLQRAGPERFLLQEVETQEG..L------gdaeae.....
K7FWI1_PELSI/5-64                 .AVCSFITKVLC.SSGGRLEFSQIPQHVGLPEPQLEQILRDVGHERFLVHMQGGC--..-------rwvlavs....
A0A1U8CE90_MESAU/5-66             .GVCCFITKILC.AHGGRMTLEGLLAEIALPEAQLCELLEAAGPDRFVLLEIVGQTG..FGEAEVA...........
F7EJ32_CALJA/5-66                 .EVCCFITKILC.AHSGRMAMDALLQEIKLSEAQLCEVLQVAGPDRFVVLETGGVAG..VTRSVVA...........
L9L233_TUPCH/5-66                 .EVCSFITKILC.AHKGRMTLEALLGEIVLSEAQLCEVLEVAGPDRFVLLEEGRTTG..VTRSVVA...........
A0A091IN00_CALAN/5-67             a-VVCFITKTLC.AQGGRMKLSELQQQIGLSAQQLEETLSAAGPQRFLVLRGSVDD-..-------vgvlavsdv..
H2QVG6_PANTR/5-66                 .TVCSFLTKVLC.AHGGRMFLKDLRGHVELSEARLRDVLQRAGPERFLLQEVETQEG..L------gdaeae.....
G1PJP6_MYOLU/5-65                 .EVCSFITK-LC.AHGGRMALDALLDEIALSEAQLLEVLEAAGPSRFVVLETGGRAG..VTRFVVA...........
A0A286XXV9_CAVPO/1-48             .-----------.-----MLLQDLRGHVELSPARLGDVLQRAGPERFLLQDVEAEAGgaRACRVVA...........
G3HH79_CRIGR/5-66                 .GVCCFITKILC.AHGGRMTLEELLAEIALPEAQLRELLEAAGPDRFVQLEIVGQTG..VTRSVVA...........
A0A2K5IBH0_COLAP/5-66             .EVCCFITKILC.THGGRMALDALLQEIALSEPQLCEVLQVAGPDRFVVLETGGEAG..ITRSVVA...........
E1BCF8_BOVIN/5-66                 .GVCCFITKILC.AHGGRMALEELLHEMQLSEEQLCEVLKEAGPDRFVVLEMGGKEG..VTRSVVA...........
ZCCHV_HUMAN/5-66                  .EVCCFITKILC.AHGGRMALDALLQEIALSEPQLCEVLQVAGPDRFVVLETGGEAG..ITRSVVA...........
H0X2S8_OTOGA/5-66                 d-VCCFITKILC.AHGGRMSLDELLREIALPEAQLLELLEQAGPDRFVVLETGSRAG..VTRSVVA...........
E1BM10_BOVIN/5-68                 .TVCSFLTKVLC.AHGGRMFLQDLRGHVELSEARLRDVLRQAGPDRFLLQEVEVREG..-------pwdaeaeva..
R4GB36_ANOCA/5-66                 .AVCSFLTKVLC.ARGGVAELGELCGEVGLPEAQLKQVLEEAGPERYLRVSRDGAAC..VLALSAA...........
D3ZIC9_RAT/5-68                   .TLCAFLTKVLC.AHGGRMFLQDLRGHVELSEAKLRAVLRRAGPERFLLQEVELRDG..-------pwdpeaeva..
L5KPW3_PTEAL/60-121               .TVCSFLTKVLC.AHGGRMLLQDLRAHVELSEARLRAVLRQAGPDRFLLQEVGVQEG..HCGG---raa........
A0A1U8CGX7_MESAU/5-66             .GVCCFITKILC.AHGGRMTLEGLLAEIALPEAQLCELLEAAGPDRFVLLEIEMQSG..-------pwdpeae....
C9J6P4_HUMAN/5-66                 .EVCCFITKILC.AHGGRMALDALLQEIALSEPQLCEVLQVAGPDRFVVLETGGEAG..ITRSVVA...........
A0A1V4K8B5_PATFA/5-67             .AVCCFITKTLC.SQGGRLGLPELQQHVGLSAQQLEETLSTAGPQRFLVVQGRG---..-------ggrevlavsal
F7GNE1_CALJA/5-66                 .EVCCFITKILC.AHSGRMAMDALLQEIKLSEAQLCEVLQVAGPDRFVVLETGGVAG..VTRSVVA...........
W5PME6_SHEEP/5-67                 .TVCSFLTKVLC.AHGGRMFLQDLRGHVELSEARLRDVLRQAGPDRFLLQEVEVREG..-------pwdaeaev...
A0A226PLL7_COLVI/5-66             v-VCNFLTKTLC.ANGGRLGLAELQQHVGLSAKQLHDTLQAAGPQRFLLRGAGGEPE..VL-----alstv......
F7EF06_CALJA/5-65                 .TVCSFLTKVLC.AHGGRMFLRDLRGHVELSEARLQDVLQRAGPERFLLQEVETQEG..L------gdpea......
A0A2K5H6M4_COLAP/5-66             .TVCSFLTKVLC.AHGGRMFLRDLRGHVELSEARLRDVLQRAGPERFLLQEVETQEG..L------gdaeae.....
F6S442_HORSE/5-66                 .EVCCFITKILC.AHGGRMSLDELLKKIALPEAQLCEVLEAAGPDRFVVLETGGKAG..VTRSVVA...........
#=GC SS_cons                      .----HHHHHHH.HTTTEEEHHHHHHHHT--HHHHHHHHHHH-TTTEEEEE------..--EEEEE...........
#=GC seq_cons                     .pVCsFlTKlLC.AHGGRMsLcsLhtcltLSEuQLp-VLptAGP-RFllhEssspsG..l.................
//
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