GenomeNet

Database: Pfam
Entry: HemN_C
LinkDB: HemN_C
Original site: HemN_C 
#=GF ID   HemN_C
#=GF AC   PF06969.17
#=GF DE   HemN C-terminal domain
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_833 (release 10.0)
#=GF GA   26.80 26.80;
#=GF TC   26.80 26.80;
#=GF NC   26.70 26.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   12196143
#=GF RT   Terminal steps of haem biosynthesis. 
#=GF RA   Dailey HA; 
#=GF RL   Biochem Soc Trans 2002;30:590-595.
#=GF RN   [2]
#=GF RM   14633981
#=GF RT   Crystal structure of coproporphyrinogen III oxidase reveals
#=GF RT   cofactor geometry of Radical SAM enzymes.
#=GF RA   Layer G, Moser J, Heinz DW, Jahn D, Schubert WD;
#=GF RL   EMBO J. 2003;22:6214-6224.
#=GF DR   INTERPRO; IPR010723;
#=GF DR   SCOP; 1olt; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Members of this family are all oxygen-independent
#=GF CC   coproporphyrinogen-III oxidases (HemN). This enzyme catalyses
#=GF CC   the oxygen-independent conversion of coproporphyrinogen-III to
#=GF CC   protoporphyrinogen-IX [1], one of the last steps in haem
#=GF CC   biosynthesis. The function of this domain is unclear, but
#=GF CC   comparison to other proteins containing a radical SAM domain
#=GF CC   (Pfam:PF04055) suggest it may be a substrate binding domain.
#=GF SQ   6564
#=GS R6BER8_9CLOT/315-380      AC R6BER8.1
#=GS A0A231V1D6_9RHIZ/326-389  AC A0A231V1D6.1
#=GS A0A270BAN0_9SPHN/302-368  AC A0A270BAN0.1
#=GS A0A432X8Q6_9GAMM/362-430  AC A0A432X8Q6.1
#=GS V6F6K5_MAGGM/307-373      AC V6F6K5.1
#=GS A0A2Z6E056_HYDTE/342-406  AC A0A2Z6E056.1
#=GS A0A1V1V228_9CAUL/321-382  AC A0A1V1V228.1
#=GS K1LSU1_9FLAO/264-329      AC K1LSU1.1
#=GS A0A2I0CUJ3_9PSED/367-435  AC A0A2I0CUJ3.1
#=GS A0A150Y967_9FIRM/313-378  AC A0A150Y967.1
#=GS H8XP63_FLAIG/364-426      AC H8XP63.1
#=GS A0Q1R7_CLONN/301-363      AC A0Q1R7.1
#=GS A0A1G9K7P3_9RHOB/315-377  AC A0A1G9K7P3.1
#=GS A0A225N0W1_9BURK/329-393  AC A0A225N0W1.1
#=GS D2QZH7_PIRSD/310-375      AC D2QZH7.1
#=GS A0A1U7MLM3_9FIRM/302-366  AC A0A1U7MLM3.1
#=GS A0A0D9QZE5_CHLSB/346-414  AC A0A0D9QZE5.1
#=GS A0A418NW50_9SPHN/302-366  AC A0A418NW50.1
#=GS A0A089LE71_9BACL/309-374  AC A0A089LE71.1
#=GS M4R617_BIBTR/312-374      AC M4R617.1
#=GS A0A1N7RUZ2_9BURK/374-442  AC A0A1N7RUZ2.1
#=GS A0A0J8YQ02_9GAMM/303-367  AC A0A0J8YQ02.1
#=GS A0A1R4GUX0_9GAMM/341-405  AC A0A1R4GUX0.1
#=GS A0A1G6AU51_9FIRM/290-354  AC A0A1G6AU51.1
#=GS A0A077ELR4_9FLAO/270-335  AC A0A077ELR4.1
#=GS A0A0R3K1N2_9CLOT/290-355  AC A0A0R3K1N2.1
#=GS A0A366EFY4_9BACI/301-365  AC A0A366EFY4.1
#=GS A0A1C1YVS5_9RHIZ/358-424  AC A0A1C1YVS5.1
#=GS A0A2T5MFC3_9GAMM/307-371  AC A0A2T5MFC3.1
#=GS A0A2W4BWW3_9RHIZ/327-388  AC A0A2W4BWW3.1
#=GS R6C6A6_9CLOT/299-358      AC R6C6A6.1
#=GS A0A2S6NNL9_RHOGL/310-376  AC A0A2S6NNL9.1
#=GS A0A087VUI6_9BIFI/393-455  AC A0A087VUI6.1
#=GS A0A0S7BH44_9CHLR/324-392  AC A0A0S7BH44.1
#=GS A0A1H3ERP1_ALLWA/310-374  AC A0A1H3ERP1.1
#=GS E1SR09_FERBD/362-430      AC E1SR09.1
#=GS W8X416_CASDE/331-395      AC W8X416.1
#=GS B6BIY5_SULGG/360-428      AC B6BIY5.1
#=GS A8LPC8_DINSH/311-373      AC A8LPC8.1
#=GS A0A1T0CGQ4_9GAMM/336-405  AC A0A1T0CGQ4.1
#=GS A8MG48_ALKOO/302-367      AC A8MG48.1
#=GS A0A1G7C4X8_9BURK/366-434  AC A0A1G7C4X8.1
#=GS A0A0J1CNB7_9BURK/364-432  AC A0A0J1CNB7.1
#=GS A0A2U2HF36_9BURK/338-401  AC A0A2U2HF36.1
#=GS A0A167I0N4_9BURK/379-447  AC A0A167I0N4.1
#=GS H5V013_ATLHE/302-366      AC H5V013.1
#=GS A0A1S8D2P9_9PROT/309-376  AC A0A1S8D2P9.1
#=GS A0A166UXB5_9GAMM/362-430  AC A0A166UXB5.1
#=GS A0A0L8QRK2_9ACTN/95-162   AC A0A0L8QRK2.1
#=GS M1ZFR0_9FIRM/302-367      AC M1ZFR0.1
#=GS U2YM85_9SPHN/300-366      AC U2YM85.1
#=GS A0A318VZ94_9ENTR/302-366  AC A0A318VZ94.1
#=GS A0A2G8E7V4_9GAMM/363-431  AC A0A2G8E7V4.1
#=GS A0A095UXK6_9FLAO/297-362  AC A0A095UXK6.1
#=GS A0A3P1XJS9_9BURK/366-434  AC A0A3P1XJS9.1
#=GS C9MPQ7_9BACT/327-388      AC C9MPQ7.1
#=GS A0A328YEP2_9FLAO/266-331  AC A0A328YEP2.1
#=GS A0A1B1N708_9BACL/316-383  AC A0A1B1N708.1
#=GS F0LWM6_VIBFN/313-376      AC F0LWM6.1
#=GS A0A0N1LF17_9SPHN/316-382  AC A0A0N1LF17.1
#=GS A0A1I3SFA4_9FLAO/297-361  AC A0A1I3SFA4.1
#=GS A0A081P8X0_9BACL/307-372  AC A0A081P8X0.1
#=GS C5ZX12_9HELI/364-432      AC C5ZX12.1
#=GS A0A327WUX3_9BACT/302-367  AC A0A327WUX3.1
#=GS U2UNG0_9FIRM/319-383      AC U2UNG0.1
#=GS V7EKX1_9RHOB/311-373      AC V7EKX1.1
#=GS A0A1B4V394_9GAMM/377-445  AC A0A1B4V394.1
#=GS A0A370X3E8_9GAMM/312-376  AC A0A370X3E8.1
#=GS A0A0S1XZ57_9BORD/335-399  AC A0A0S1XZ57.1
#=GS A0A2U9TAR5_9GAMM/364-428  AC A0A2U9TAR5.1
#=GS A0A098EMJ0_9BACL/314-379  AC A0A098EMJ0.1
#=GS A0A327KLZ1_9RHIZ/321-384  AC A0A327KLZ1.1
#=GS A0A0F7K008_9GAMM/367-435  AC A0A0F7K008.1
#=GS A0A429ZXA4_9ENTE/300-365  AC A0A429ZXA4.1
#=GS A0A401UHS2_9CLOT/297-362  AC A0A401UHS2.1
#=GS A0A0J8DBG5_CLOCY/291-355  AC A0A0J8DBG5.1
#=GS A0A3N9THA0_9VIBR/310-372  AC A0A3N9THA0.1
#=GS C6IZF9_9BACL/330-397      AC C6IZF9.1
#=GS A0A0J1DEZ5_9BURK/338-402  AC A0A0J1DEZ5.1
#=GS A0A1T4Q6X3_ENTAG/302-366  AC A0A1T4Q6X3.1
#=GS D4W1S1_9FIRM/300-365      AC D4W1S1.1
#=GS R9LZ69_9FIRM/291-353      AC R9LZ69.1
#=GS A0A448FGU9_9BACI/328-393  AC A0A448FGU9.1
#=GS A0A3B0MNX5_9RHOB/311-373  AC A0A3B0MNX5.1
#=GS A0A1M5W4V5_9BURK/333-397  AC A0A1M5W4V5.1
#=GS A0A0B8PK36_9VIBR/314-378  AC A0A0B8PK36.1
#=GS Q01GW5_OSTTA/368-414      AC Q01GW5.1
#=GS A0A495AKJ8_9ENTR/363-431  AC A0A495AKJ8.1
#=GS J3D026_9BURK/344-406      AC J3D026.1
#=GS A0A1B4XC79_9GAMM/308-372  AC A0A1B4XC79.1
#=GS X0PHE9_9LACO/303-365      AC X0PHE9.1
#=GS A0A318MVT0_9PROT/322-388  AC A0A318MVT0.1
#=GS A0A1I6JV54_9ALTE/305-367  AC A0A1I6JV54.1
#=GS A0A0Q7AK81_9BURK/331-395  AC A0A0Q7AK81.1
#=GS A0A117J3A4_9FIRM/304-362  AC A0A117J3A4.1
#=GS A0A343JDR8_9CLOT/298-363  AC A0A343JDR8.1
#=GS M2XV41_GALSU/356-408      AC M2XV41.1
#=GS I3ZH51_TERRK/318-383      AC I3ZH51.1
#=GS A0A243SJA0_9FLAO/297-362  AC A0A243SJA0.1
#=GS A0A1I1QUL5_9GAMM/362-430  AC A0A1I1QUL5.1
#=GS A0A327M406_9PROT/359-420  AC A0A327M406.1
#=GS A0A1Q2D3U0_9ENTE/310-375  AC A0A1Q2D3U0.1
#=GS A0A3D9L9Y1_9MICC/349-414  AC A0A3D9L9Y1.1
#=GS A0A1I2H1Z9_9GAMM/311-375  AC A0A1I2H1Z9.1
#=GS A0A1G6ZJ51_9BURK/327-391  AC A0A1G6ZJ51.1
#=GS A0A2I1M8N7_9FIRM/300-363  AC A0A2I1M8N7.1
#=GS A0A2T5BEU9_MYCDI/324-387  AC A0A2T5BEU9.1
#=GS A0A3N1IW67_9ENTR/302-366  AC A0A3N1IW67.1
#=GS A0A2N5Y549_9GAMM/306-370  AC A0A2N5Y549.1
#=GS A0A1B6BCP7_9FIRM/315-382  AC A0A1B6BCP7.1
#=GS F9QBU5_9PAST/361-429      AC F9QBU5.1
#=GS H3SE04_9BACL/318-384      AC H3SE04.1
#=GS D4MXW5_ANAHA/302-367      AC D4MXW5.1
#=GS A0A3S8T1N7_9RICK/305-367  AC A0A3S8T1N7.1
#=GS A0A0A1YGY6_9PSED/367-435  AC A0A0A1YGY6.1
#=GS K2KEJ1_9GAMM/301-364      AC K2KEJ1.1
#=GS A0A2H3NNP6_9BACT/294-360  AC A0A2H3NNP6.1
#=GS A0A1X6ZN29_9RHOB/311-373  AC A0A1X6ZN29.1
#=GS E8TGL5_MESCW/359-427      AC E8TGL5.1
#=GS A0A0H4VPG1_9BACT/298-363  AC A0A0H4VPG1.1
#=GS G1NUT8_MYOLU/342-410      AC G1NUT8.1
#=GS A0A3M2L6S1_9NOCA/366-431  AC A0A3M2L6S1.1
#=GS A0A1E1F6I0_9SPHN/313-379  AC A0A1E1F6I0.1
#=GS Q8YMH7_NOSS1/316-380      AC Q8YMH7.1
#=GS A0A154QYY8_9GAMM/372-440  AC A0A154QYY8.1
#=GS A0A252EA92_9NOSO/313-379  AC A0A252EA92.1
#=GS RSAD1_MOUSE/346-414       AC Q5SUV1.1
#=GS A0A0A0EYH1_9GAMM/369-437  AC A0A0A0EYH1.1
#=GS A0A1G5RTJ2_9FIRM/300-365  AC A0A1G5RTJ2.1
#=GS A0A1G9R8W8_9RHOB/309-371  AC A0A1G9R8W8.1
#=GS A0A2Z6I860_9BURK/325-389  AC A0A2Z6I860.1
#=GS A0A363S2R1_9GAMM/375-443  AC A0A363S2R1.1
#=GS A0A1H2HF45_9PSED/312-376  AC A0A1H2HF45.1
#=GS F3S5E0_9PROT/363-430      AC F3S5E0.1
#=GS A0A1S2REA6_9BACI/301-366  AC A0A1S2REA6.1
#=GS A0A2Z5YY43_9SPHN/300-366  AC A0A2Z5YY43.1
#=GS N6WXR0_9ALTE/382-450      AC N6WXR0.1
#=GS A0A139BTI1_9PROT/321-385  AC A0A139BTI1.1
#=GS A0A0J1F8A2_9FIRM/371-433  AC A0A0J1F8A2.1
#=GS A0A087CV02_9BIFI/348-425  AC A0A087CV02.1
#=GS A0A226BVQ4_9FIRM/313-375  AC A0A226BVQ4.1
#=GS A0A286CZ35_9GAMM/404-472  AC A0A286CZ35.1
#=GS A0A0W0VBC2_9GAMM/304-368  AC A0A0W0VBC2.1
#=GS A0A366HDX5_9BURK/340-404  AC A0A366HDX5.1
#=GS F6Z360_XENTR/342-410      AC F6Z360.1
#=GS A0A327K5A7_9RHIZ/356-425  AC A0A327K5A7.1
#=GS A0A3N8MJG8_9BURK/328-391  AC A0A3N8MJG8.1
#=GS A0A1Z5H9A9_9GAMM/323-387  AC A0A1Z5H9A9.1
#=GS A0A415X497_9FIRM/324-389  AC A0A415X497.1
#=GS A0A255R707_9PLAN/349-413  AC A0A255R707.1
#=GS A0A2T4VKE2_9DELT/333-397  AC A0A2T4VKE2.1
#=GS A0A0S4Q482_BLAVI/301-364  AC A0A0S4Q482.1
#=GS Q8A5S0_BACTN/298-363      AC Q8A5S0.1
#=GS A0A2N7QMY1_9GAMM/312-376  AC A0A2N7QMY1.1
#=GS A0A374X2P3_9FIRM/323-386  AC A0A374X2P3.1
#=GS A0A066UFF6_9GAMM/326-390  AC A0A066UFF6.1
#=GS A0A2S6CZB9_9CYAN/313-375  AC A0A2S6CZB9.1
#=GS A0A1I4TQB4_9GAMM/378-446  AC A0A1I4TQB4.1
#=GS A0A1I0MSC3_9RHOB/311-373  AC A0A1I0MSC3.1
#=GS A0A175Y5L6_9SPHN/309-373  AC A0A175Y5L6.1
#=GS A0A1Q4XUZ9_9ACTN/338-402  AC A0A1Q4XUZ9.1
#=GS A0A345DCU7_9BURK/327-391  AC A0A345DCU7.1
#=GS A0A0K0U0U2_9RHIZ/312-375  AC A0A0K0U0U2.1
#=GS A0A098SRC0_9PSED/329-393  AC A0A098SRC0.1
#=GS A0A1V1W6H0_9ACTN/340-397  AC A0A1V1W6H0.1
#=GS I7GYJ5_9HELI/364-432      AC I7GYJ5.1
#=GS A0A372BWG0_9GAMM/308-364  AC A0A372BWG0.1
#=GS A0A239SH37_9BURK/327-391  AC A0A239SH37.1
#=GS A0A2T0T0T8_9BACT/297-362  AC A0A2T0T0T8.1
#=GS A0A221MC41_9BACI/301-365  AC A0A221MC41.1
#=GS N1ZJX0_9CLOT/300-365      AC N1ZJX0.1
#=GS L0GUG9_9GAMM/323-387      AC L0GUG9.1
#=GS A0A0F5IC78_9BACI/300-366  AC A0A0F5IC78.1
#=GS A0A418NJ98_9SPHN/300-366  AC A0A418NJ98.1
#=GS S1N7Y3_9ENTE/311-376      AC S1N7Y3.1
#=GS A0A0P1EM71_9RHOB/311-373  AC A0A0P1EM71.1
#=GS A0A0W0U8L1_9GAMM/302-365  AC A0A0W0U8L1.1
#=GS F4LSH3_TEPAE/299-364      AC F4LSH3.1
#=GS A0A2U8VLQ8_9RHIZ/318-379  AC A0A2U8VLQ8.1
#=GS A0A2H5AVU8_9ACTN/360-423  AC A0A2H5AVU8.1
#=GS C4L9H1_TOLAT/363-431      AC C4L9H1.1
#=GS I4Z0N9_9RHIZ/358-425      AC I4Z0N9.1
#=GS HEMN_SALTY/363-431        AC P0A1E1.1
#=GS A0A1M5YD71_9GAMM/302-365  AC A0A1M5YD71.1
#=GS A0A1B3SK14_9MOLU/298-359  AC A0A1B3SK14.1
#=GS Q0P9R0_CAMJE/358-424      AC Q0P9R0.1
#=GS A0A3S0JS27_9BACI/303-368  AC A0A3S0JS27.1
#=GS A0A074KZP9_9BACT/298-363  AC A0A074KZP9.1
#=GS A0A0B8Q076_9VIBR/363-431  AC A0A0B8Q076.1
#=GS A4SXT4_POLAQ/317-381      AC A4SXT4.1
#=GS A0A1Y0CYP1_9GAMM/305-369  AC A0A1Y0CYP1.1
#=GS D2UCI4_XANAP/306-370      AC D2UCI4.1
#=GS A0A437JBJ5_9SPHN/315-381  AC A0A437JBJ5.1
#=GS A0A0A0F0B9_9GAMM/311-375  AC A0A0A0F0B9.1
#=GS Q2SJT2_HAHCH/366-434      AC Q2SJT2.1
#=GS A0A0A1H3G5_9BURK/363-431  AC A0A0A1H3G5.1
#=GS J0U1L8_9BURK/366-434      AC J0U1L8.1
#=GS A0A2T5P9A1_9PSED/315-379  AC A0A2T5P9A1.1
#=GS A0A1P8UEC9_9GAMM/368-436  AC A0A1P8UEC9.1
#=GS A0A1L8SXQ2_9ENTE/302-367  AC A0A1L8SXQ2.1
#=GS R5Z6X5_9FIRM/376-441      AC R5Z6X5.1
#=GS A0A3Q9R0K1_9BACI/300-365  AC A0A3Q9R0K1.1
#=GS E5YA03_BILWA/298-363      AC E5YA03.1
#=GS A0A249LFU5_9ACTN/306-363  AC A0A249LFU5.1
#=GS M7NF63_9BACL/303-368      AC M7NF63.1
#=GS A0A1I6AKF9_9PSEU/391-454  AC A0A1I6AKF9.1
#=GS W6LSX0_9GAMM/367-435      AC W6LSX0.1
#=GS A0A0Q5W781_9RHIZ/320-380  AC A0A0Q5W781.1
#=GS R6YIM7_9FIRM/305-370      AC R6YIM7.1
#=GS A0A1L6I093_9BURK/329-392  AC A0A1L6I093.1
#=GS A0A1K1YW96_9BACL/303-368  AC A0A1K1YW96.1
#=GS A0A3N5C0J1_9BACI/300-365  AC A0A3N5C0J1.1
#=GS A0A3A9CE28_9BACT/306-375  AC A0A3A9CE28.1
#=GS A0A090SNL3_9VIBR/369-437  AC A0A090SNL3.1
#=GS A0A1L8PTN0_9RHIZ/319-380  AC A0A1L8PTN0.1
#=GS I7A1I3_MELRP/364-432      AC I7A1I3.1
#=GS M1F9Q1_9ALTE/311-373      AC M1F9Q1.1
#=GS A0A3A9ARI3_9BACT/343-401  AC A0A3A9ARI3.1
#=GS A0A2T0XJ79_9PROT/331-395  AC A0A2T0XJ79.1
#=GS B8GPB5_THISH/306-370      AC B8GPB5.1
#=GS A0A2K4ZDR3_9FIRM/308-361  AC A0A2K4ZDR3.1
#=GS F7Q874_9GAMM/367-435      AC F7Q874.1
#=GS E5AQW0_PARRH/116-184      AC E5AQW0.1
#=GS A0A142LIG2_9PROT/376-444  AC A0A142LIG2.1
#=GS A0A3M8S6Z7_9PROT/23-91    AC A0A3M8S6Z7.1
#=GS A0A0E9ML52_9SPHN/302-366  AC A0A0E9ML52.1
#=GS H6L3A6_SAPGL/268-333      AC H6L3A6.1
#=GS A0A0M7B9F1_9RHOB/239-300  AC A0A0M7B9F1.1
#=GS A0A1M5JTN3_9FLAO/319-384  AC A0A1M5JTN3.1
#=GS Q12E83_POLSJ/368-436      AC Q12E83.1
#=GS S5ZNX9_9SPIO/307-371      AC S5ZNX9.1
#=GS A0A427U651_9VIBR/368-436  AC A0A427U651.1
#=GS A0A199XRG1_9FLAO/315-380  AC A0A199XRG1.1
#=GS A0A3N1Y9J5_9GAMM/369-437  AC A0A3N1Y9J5.1
#=GS A0A2M8GX83_9VIBR/308-372  AC A0A2M8GX83.1
#=GS A0A0D0S7I1_9GAMM/314-378  AC A0A0D0S7I1.1
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R6BER8_9CLOT/315-380                 ............................LNEEDKMNEFMMLGLR.K..ID.GV.N..IG..D..F..K..K....I.....F.GVN............PIMKY...C...K...T...L...D...K...L...T...H...E...D.L....I..Q....V.....D.E.........NS.IK.LSKKGI-d............................
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