#=GF ID HepII_C
#=GF AC PF18675.5
#=GF DE Heparinase II C-terminal domain
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF07810
#=GF GA 26.10 26.10;
#=GF TC 26.20 26.20;
#=GF NC 25.80 25.10;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF CL CL0369
#=GF RN [1]
#=GF RM 20404324
#=GF RT Catalytic mechanism of heparinase II investigated by
#=GF RT site-directed mutagenesis and the crystal structure with its
#=GF RT substrate.
#=GF RA Shaya D, Zhao W, Garron ML, Xiao Z, Cui Q, Zhang Z, Sulea T,
#=GF RA Linhardt RJ, Cygler M;
#=GF RL J Biol Chem. 2010;285:20051-20061.
#=GF RN [2]
#=GF RM 16565082
#=GF RT Crystal structure of heparinase II from Pedobacter heparinus and
#=GF RT its complex with a disaccharide product.
#=GF RA Shaya D, Tocilj A, Li Y, Myette J, Venkataraman G, Sasisekharan
#=GF RA R, Cygler M;
#=GF RL J Biol Chem. 2006;281:15525-15535.
#=GF DR INTERPRO; IPR040925;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Heparinase II (HepII) is an 85-kDa dimeric enzyme that
#=GF CC depolymerizes both heparin and heparan sulfate
#=GF CC glycosaminoglycans [1]. The protein is composed of three
#=GF CC domains: an N-terminal alpha-helical domain, a central
#=GF CC two-layered beta-sheet domain, and a C-terminal domain forming a
#=GF CC two-layered beta-sheet. The C-terminal domain contains nine
#=GF CC beta-strands packed together in a manner resembling a
#=GF CC beta-barrel [2].
#=GF SQ 82
#=GS A0A5C4SQX4_9FLAO/688-774 AC A0A5C4SQX4.1
#=GS A0A2U1AV97_9BACT/960-1042 AC A0A2U1AV97.1
#=GS A0A1W1X2T0_9CLOT/667-756 AC A0A1W1X2T0.1
#=GS G8T747_NIAKG/803-884 AC G8T747.1
#=GS A0A399CXW3_9BACT/822-901 AC A0A399CXW3.1
#=GS A0A1H3YC88_9BACT/823-901 AC A0A1H3YC88.1
#=GS A0A1K1N728_9BACL/733-819 AC A0A1K1N728.1
#=GS A0A1W1ZTQ5_9SPHI/833-915 AC A0A1W1ZTQ5.1
#=GS A0A1G8U0S8_9SPHI/831-914 AC A0A1G8U0S8.1
#=GS A0A5C6CYE7_9BACT/683-773 AC A0A5C6CYE7.1
#=GS A0A5C4T752_9BACL/1344-1429 AC A0A5C4T752.1
#=GS A0A8G2F280_9BACT/827-907 AC A0A8G2F280.1
#=GS A0A1W2BZE5_9SPHI/801-879 AC A0A1W2BZE5.1
#=GS A0A329LFU7_9BACL/1082-1183 AC A0A329LFU7.1
#=GS A0A5N5ITR1_9FLAO/818-900 AC A0A5N5ITR1.1
#=GS A0A1K1PIX9_9BACL/1169-1253 AC A0A1K1PIX9.1
#=GS A0A5S5CB00_9BACL/1312-1398 AC A0A5S5CB00.1
#=GS A0A5C6CQ48_9BACT/827-910 AC A0A5C6CQ48.1
#=GS A0A285ZYT3_9SPHI/814-900 AC A0A285ZYT3.1
#=GS HEPB_PEDHD/686-772 AC C6XZB6.1
#=GS A0A1I0V8H9_9BACL/1036-1124 AC A0A1I0V8H9.1
#=GS A0A3B0C7J4_9BACL/678-779 AC A0A3B0C7J4.1
#=GS R6DEZ3_9BACE/685-771 AC R6DEZ3.1
#=GS A0A7W5GD51_9BACL/1398-1484 AC A0A7W5GD51.1
#=GS A0A3G9IYW6_9BACL/1281-1368 AC A0A3G9IYW6.1
#=GS A0A2R4CAG7_9BURK/914-997 AC A0A2R4CAG7.1
#=GS A0A5C6CY00_9BACT/743-827 AC A0A5C6CY00.1
#=GS A0A7K0G1W7_9SPHI/703-789 AC A0A7K0G1W7.1
#=GS A0A1G9JBH5_9SPHI/686-772 AC A0A1G9JBH5.1
#=GS A0A1K1QJ87_9BACL/1477-1563 AC A0A1K1QJ87.1
#=GS A0A1K1QD68_9BACL/855-942 AC A0A1K1QD68.1
#=GS A0A0K1K231_9BURK/867-953 AC A0A0K1K231.1
#=GS A0A399CUK3_9BACT/680-766 AC A0A399CUK3.1
#=GS A0A1K1PQ87_9BACL/1259-1344 AC A0A1K1PQ87.1
#=GS A0A120A181_BACSE/694-780 AC A0A120A181.1
#=GS A0A5S5CLB8_9BACL/1178-1264 AC A0A5S5CLB8.1
#=GS A0A2R4C7M8_9BURK/860-946 AC A0A2R4C7M8.1
#=GS U2HSS2_9SPHI/823-906 AC U2HSS2.1
#=GS A0A1I0V8S6_9BACL/1011-1098 AC A0A1I0V8S6.1
#=GS A0A2V5KAB2_9BACL/715-803 AC A0A2V5KAB2.1
#=GS A0A5S5CHX2_9BACL/1195-1278 AC A0A5S5CHX2.1
#=GS A0A5C4T581_9BACL/1301-1386 AC A0A5C4T581.1
#=GS A0A5S5BXJ8_9BACL/725-810 AC A0A5S5BXJ8.1
#=GS A0A2Z3MZJ1_9BACT/827-907 AC A0A2Z3MZJ1.1
#=GS A0A1M4WMJ5_9BACT/673-759 AC A0A1M4WMJ5.1
#=GS A0A3B0BYU1_9BACL/1301-1386 AC A0A3B0BYU1.1
#=GS A0A1I1CI18_9BACL/1188-1273 AC A0A1I1CI18.1
#=GS A0A374VCG6_9BACE/686-772 AC A0A374VCG6.1
#=GS A0A4S4BH90_9BACL/1030-1115 AC A0A4S4BH90.1
#=GS A0A840CN47_9BACT/820-903 AC A0A840CN47.1
#=GS D7VQL3_SPHSI/814-895 AC D7VQL3.1
#=GS A0A1I0V8D6_9BACL/1010-1097 AC A0A1I0V8D6.1
#=GS A0A1I0V8D1_9BACL/729-814 AC A0A1I0V8D1.1
#=GS F5IYN7_9BACT/814-894 AC F5IYN7.1
#=GS A0A1Y5K6V9_9BACL/652-740 AC A0A1Y5K6V9.1
#=GS A0A3B0BZF1_9BACL/650-739 AC A0A3B0BZF1.1
#=GS A0A5S5CB74_9BACL/995-1082 AC A0A5S5CB74.1
#=GS A0A120A2Q3_BACSE/687-773 AC A0A120A2Q3.1
#=GS A0A098M3H4_9BACL/985-1072 AC A0A098M3H4.1
#=GS A0A257I2B2_9BACT/674-758 AC A0A257I2B2.1
#=GS A0A2V5KCG9_9BACL/689-777 AC A0A2V5KCG9.1
#=GS A0A1K1N942_9BACL/950-1037 AC A0A1K1N942.1
#=GS A0A1K1N949_9BACL/1118-1205 AC A0A1K1N949.1
#=GS A0A1K1PQC1_9BACL/926-1013 AC A0A1K1PQC1.1
#=GS A0A3N4PA15_9BACT/824-902 AC A0A3N4PA15.1
#=GS A0A1I4M176_9BURK/868-955 AC A0A1I4M176.1
#=GS A0A1K1N9Z0_9BACL/1644-1729 AC A0A1K1N9Z0.1
#=GS A0A0M2WUR3_9BURK/848-936 AC A0A0M2WUR3.1
#=GS A0A2U1AP12_9BACT/969-1055 AC A0A2U1AP12.1
#=GS A0A1W2CNQ0_9SPHI/682-768 AC A0A1W2CNQ0.1
#=GS A0A4Q9DSQ0_9BACL/649-742 AC A0A4Q9DSQ0.1
#=GS A0A1V4HKR3_9BACL/850-940 AC A0A1V4HKR3.1
#=GS A0A0M3CIX7_9SPHI/393-472 AC A0A0M3CIX7.1
#=GS A0A1R3T3S2_9BACT/828-909 AC A0A1R3T3S2.1
#=GS A0A1W1ZZK8_9SPHI/817-902 AC A0A1W1ZZK8.1
#=GS A0A1Y5KIG6_9BACL/1580-1665 AC A0A1Y5KIG6.1
#=GS A0A5S5CKJ8_9BACL/1014-1101 AC A0A5S5CKJ8.1
#=GS A0A1I0YPU4_9BACL/1397-1483 AC A0A1I0YPU4.1
#=GS A0A5C4SVN4_9BACL/1192-1279 AC A0A5C4SVN4.1
#=GS A0A399CZW3_9BACT/835-917 AC A0A399CZW3.1
#=GS A0A1W2APK4_9SPHI/686-772 AC A0A1W2APK4.1
#=GS A0A3G9J2U5_9BACL/871-959 AC A0A3G9J2U5.1
A0A5C4SQX4_9FLAO/688-774 ................e-ILGDEVFGVQIKDRIVLFNKR.SSQMDLPFSF.S..V.K...E.....-..............KG.NY.KFLITDVEEGTWQIK.....K.NGKV.L.HV.A......IRADKT.DNVLYFEGS.H.GD.YEVIR..........
A0A2U1AV97_9BACT/960-1042 ..........eqgrvrl---------VTVADWAVMLPAD.GREVKEEFQL.A..V.P...E.....-..............-G.KT.RVLLTSLQPGFWNVT.....T.PGGD.S.F-.N......FTVKQG.DGTAAFDGG.Q.GS.YLL--kp........
A0A1W1X2T0_9CLOT/667-756 ................k-INGSDNIGVVISNYAVMFNKG.GEDFKKNVTF.D..L.T...Cl...qA..............NK.KY.KLLFCDLQEGEWTVY.....K.DGKK.I.ME.Q......KTVNRN.AGSIFCVGT.S.GK.YTFK-y.........
G8T747_NIAKG/803-884 ...........qagyye---------VRVADIVQVLS-A.GESINETVTI.D..I.P...A.....-..............-G.TY.NLVATGLKEGFWHVR.....K.KGET.A.NT.N......YYVRPG.KNTLQVHLP.E.GS.YELL-p.........
A0A399CXW3_9BACT/822-901 .............yfiy-----------MADYVICMSST.TGQNQDSFSL.S..I.S...G.....-..............NN.ER.KVLLTDLSPGEWTVS.....S.SDKK.V.EF.N......RKVSAN.QNTIFFEAS.P.GE.YQI--cp........
A0A1H3YC88_9BACT/823-901 .............syyl---------VGLADQLVCMSTG.SELVNTAIDL.D..I.Q...A.....-..............--.NT.KVTLTGLKPGFWTVK.....GpDGKS.R.N-.-......FDIRQG.KNTLYFEGV.A.GK.YSI--mp........
A0A1K1N728_9BACL/733-819 ..............tns----KRHDGVMILDRVVFFAQS.GERNSDTLNF.T..V.T...N.....H.............tYG.NL.KFLITDMAAGVWCVQ.....L.NGGS.C.SL.V......RS-TKE.GGFIDFEGA.P.GP.YTIT-n.........
A0A1W1ZTQ5_9SPHI/833-915 ...........mgacyq---------VTVADRVVVMSSG.SDLIHSSFTV.D..V.P...V.....-..............GA.AY.QIVLTGLKEGFWNVR.....R.IGQK.D.NF.N......FNVVPG.KHTMSFQGA.A.GK.Y----ivs.......
A0A1G8U0S8_9SPHI/831-914 ..........etgacyq---------VRIADRIVVMSSS.SDFIRSSFTV.D..V.P...A.....-..............GS.AY.QVVLTGLDSGFWNVK.....NaDGKV.N.FN.Y......DVVPG-.KNTISFKTE.G.GK.F----iat.......
A0A5C6CYE7_9BACT/683-773 lvdradrvgsfierpeg-------------NRLVLFRRD.GQRSSHPVTI.E..V.S...G.....-..............PG.KT.GVLVADLTAGVWHLR.....R.AGES.S.TR.E......IRVDRD.LGAAWFEAS.P.GN.WQM--ek........
A0A5C4T752_9BACL/1344-1429 ................t-VESERMVGAAVSDAVVLFAKS.GDRESGTVSF.S..V.Y...G.....N..............EE.KL.QFIVTDLAAGSWSIA.....-.-GGT.Q.QA.R......GEVTAD.GGVLYFTGA.P.GD.YTLT-y.........
A0A8G2F280_9BACT/827-907 ...........gqyiic-----------LQDRMVCLSSG.YQQIQSPFTL.K..V.D...Q.....-..............SS.ES.QILITDLKPGFWNVQ.....S.ENGA.I.NI.N......FKVKTG.KNTIFFRGG.K.GR.YL---it........
A0A1W2BZE5_9SPHI/801-879 ..............wql----------AVADRVVCLSSG.GGLLENTFTV.D..V.P...D.....-..............AG.MF.EVLLTDMKPGYWNVK.....S.SDGK.M.NF.N......YAVMSG.KNTLFFKAE.K.GS.YV---va........
A0A329LFU7_9BACL/1082-1183 ..............rll---TDGMVGARIADRLVYFSRS.GQLLGDTVSL.S..V.Y...G.....SvydtaggetdgfvaDA.KW.KVLLTDMPAGYWRID.....R.NGVE.G.EV.E......YEVAVE.SGTLYFEAD.E.GD.YVIR-r.........
A0A5N5ITR1_9FLAO/818-900 ............dtyyl---------VRLADKIVYISKG.KDLVEESIKV.T..I.P...D.....E..............VE.EV.EVIFAGIKEGYWNVY.....D.KKSG.L.NA.N......ILVDFG.KNVVSFRSK.G.GE.Y----vvg.......
A0A1K1PIX9_9BACL/1169-1253 ................r-IEAGSMEGAKLADRVVLFSKS.GERLSGKLEL.D..A.P...G.....-..............AG.TL.QYVIADLKEGLWRIE.....-.-GGA.A.AS.D......GVVTKE.GGVLAFSGH.A.GK.YTLT-y.........
A0A5S5CB00_9BACL/1312-1398 ................l-LDTNLMTGAQIADRAVWFSKS.GDRLTGSITL.S..T.N...G.....I..............LA.DM.LLTVADLESGTWRIS.....M.SGQP.-.DQ.Y......GEVTVE.GGVLAFRAP.A.GS.YTLA-k.........
A0A5C6CQ48_9BACT/827-910 ..........eteqnfv---------VHLADRVVSMSKG.SALLEASFTI.Q..V.L...G.....-..............EG.KR.QVLLTGLKPGNWNVQ.....SgDGKQ.-.IT.A......AKVSAG.QNTMYFEAN.A.GE.F----lvt.......
A0A285ZYT3_9SPHI/814-900 ........ivekanyfm---------FQLADKVVLMAKP.NAYLAEEIEI.K..V.P...A.....-..............GK.TH.EVICVGFAPGFWEVK.....K.METR.K.VK.N......ENILKD.RNSFSWNAD.Q.GI.YKLL-p.........
HEPB_PEDHD/686-772 .................RIDGDKVVGVQLADRIVTFSKT.SETVDRPFGF.S..V.V...G.....-..............KG.TF.KFVMTDLLPGTWQVL.....K.DGKI.L.YP.A......LSAKGD.DGALYFEGT.E.GT.YRFLR..........
A0A1I0V8H9_9BACL/1036-1124 ...............se---TNDYAGARIQDRVVFFAKD.FDLVDQQATI.A..F.D...G.....A..............AG.QIyKILVADLEAGYWTVV.....K.QGGS.AaTV.K......YQAVQA.GNTIYFEGT.P.GT.YTLQ-k.........
A0A3B0C7J4_9BACL/678-779 ................k-LESPALIGTFVGDWIVLFAKS.GLRQPGEIELpD..I.PpgpG....dE..............KR.EY.SFLVADLEAGSWAVEerqadR.DGTD.G.PN.EpeqqtfYEVTGE.GGVLH----.-.--.-----mrrkapcgkl
R6DEZ3_9BACE/685-771 ................l-LKGENLVGAVIADRIVTFSKN.GETINGKAEM.D..V.Q...G.....-..............NG.TF.KFVMTDMKPGTWQVK.....K.DGKI.F.IP.Y......KWVGTE.DGVLSFEGG.S.GH.YEFFR..........
A0A7W5GD51_9BACL/1398-1484 ................r-LDANLMTGVQIADRAVWFSKS.GQRLNESVTL.S..V.Y...G.....S..............QA.DI.TVTVADMHAGNWEIS.....M.PGQA.-.DR.T......GVVSEE.GGVLSFAAP.A.GT.YTLT-p.........
A0A3G9IYW6_9BACL/1281-1368 ...............se---TDDYAGATIHDRVVFFAKG.FELIDQEATI.T..F.E...G....vE..............DQ.TY.KILVTDLADGDWTAV.....K.EGET.A.AV.K......YKVVKE.GNTIYFEGT.P.GT.YTLQ-k.........
A0A2R4CAG7_9BURK/914-997 ...............tt---GNIMLGALIDNRAVYFAKS.ALPVTVQTTL.K..L.D...A.....-..............-G.TY.NLLVTDLATGTWSVK.....-.-GPS.G.TV.E......KVVEES.HGTIYLPAT.A.GGeYVL--tp........
A0A5C6CY00_9BACT/743-827 ......ygshikaddpi---------------CVVFSKD.GSE-DNSVTF.A..VtQ...S.....F..............SG.TA.RFLICDLQEANYEVR.....K.NGMP.L.SG.Y......QDVNVGlDGTLYFEDT.SfGQ.YS---ig........
A0A7K0G1W7_9SPHI/703-789 ................r-VETDRFVGTTIGDRMVLFNKN.GDLAATAINL.K..I.T...A.....-..............KG.TT.KVLIADLAKGNWSIK.....C.LSNS.K.NS.I......NDLYNK.DGLLYFNAG.Q.GE.YIIK-r.........
A0A1G9JBH5_9SPHI/686-772 .................RIDGDKVVGVQLADRIVTFSKT.SETIDRPFNF.S..V.V...G.....-..............KG.TF.KFVITDLLAGTWQVL.....K.DGKV.F.QP.A......LSARSD.DGALYFTGT.E.GT.YRFLR..........
A0A1K1QJ87_9BACL/1477-1563 ................r-LDADLMTGAQIDDRAVWFSKS.GKRLNQTVTL.S..A.Y...G.....S..............QP.EM.MLTVADLQQGKWRIS.....M.AGKP.D.-Q.F......GEVSDE.GGVLAFHAP.A.GS.YTLT-p.........
A0A1K1QD68_9BACL/855-942 ................q-VNGDKFVGAKISNRVVLFGKE.SQPISDTATF.T..V.S...G.....S..............ER.NL.YYLVTDLTPGYWTVT.....K.AGET.A.AT.Q......IEVTQE.KGELYFQGS.P.GA.YTLT-h.........
A0A0K1K231_9BURK/867-953 ...............ge---NDALVGAKIADRAVLFANS.TEDLASSASF.T..L.P...A.....F..............SG.EL.KVLITALAPGNWSVV.....A.EDGT.F.RF.D......GPVSAQ.EGTLYFSVK.N.GGrYTL--r.........
A0A399CUK3_9BACT/680-766 ................a-ISGEKIVGAQLSDRVVTFSKN.AETIDRPFDL.N..V.T...G.....-..............KG.TF.KFMVTDLDAGTWQVH.....K.NGEV.Y.LP.A......IPVNPG.DGILYFEGE.Q.GE.YQFFR..........
A0A1K1PQ87_9BACL/1259-1344 ................k-LETDQLIGAQLADQAVLFSKD.GNRHEGNVTF.Q..V.Y...G.....S..............SP.SM.NVVVADLTAGVWKIS.....R.NGRE.L.Y-.-......REVTED.GGLLHVEGA.A.GT.YALT-y.........
A0A120A181_BACSE/694-780 ................r-IEDDRIVGVQLADRVVTFARS.SEPLQKDFTL.T..V.N...G.....-..............TG.TY.KFVITDLKAGNWQVK.....K.DGRI.F.IP.L......TEVQAS.DGVLAFEGS.A.GS.YEFCR..........
A0A5S5CLB8_9BACL/1178-1264 ................k-LDASAMVGVQLADRAVLFSKT.GKRLSGTVTF.E..I.D...E.....G..............TD.AI.EYAVTDLKPGIWKIE.....H.DGGV.Q.--.Y......GSVTEE.GNVLTFTGP.A.GTtYTLT-s.........
A0A2R4C7M8_9BURK/860-946 ................l-LQSAQFVGARVANRVVLFGKG.ETSVGTGASF.L..L.L...A.....-..............-E.PA.DVLIADLQPGTWQVK.....K.NGVL.Q.AG.S......YVVGAD.DGTIYLQAQ.GaGA.YELV-l.........
U2HSS2_9SPHI/823-906 ...........tevsyv---------VVVENHIVSMNRL.EHPIGKEFEI.E..I.P...K.....-..............GK.HN.HIVLTGLKGGGWNVY.....Y.ENKKnK.LI.D......TKVEED.KNTLYFEGK.K.GK.YI---it........
A0A1I0V8S6_9BACL/1011-1098 ...............se---TDDYAGARIYDRVVFFAKD.FGLIDQEATI.A..F.D...G.....E..............AGqTY.KVLVTDLAEGDWTAV.....K.AGDT.A.SV.K......YKVVKD.GNTLYFQGT.P.GT.YTLQ-k.........
A0A2V5KAB2_9BACL/715-803 ................g-LDSEKMEGVRIADRAVWFAKS.GSKLDERLRL.D..V.G...GpeaggE..............GG.LV.QVVVTDLAAGVWKV-.....-.DGA-.A.NT.E......AVVTEE.GGALYFSGP.A.GS.YTI--r.........
A0A5S5CHX2_9BACL/1195-1278 ..............aas-----GMVGVQLTNRAVLFSKS.GKRLSGTVNV.T..T.T...G.....S..............MT.NM.EYVVADLQAGSWKIS.....R.NGV-.-.ES.Y......GTVSEE.GGVLSFTGA.P.GT.YTLTR..........
A0A5C4T581_9BACL/1301-1386 .................AIDSDRMVGAAIADSIVLFSKS.GDRERGALTF.S..V.P...G.....N..............QQ.SL.QFAVADLSAGTWHIA.....G.GGKE.A.Y-.-......GEVSEE.GGVLYFHGA.T.GA.YTLT-y.........
A0A5S5BXJ8_9BACL/725-810 ...........nakrhd--------GVMILDRVVFFAQS.GGRNSDTLKF.N..V.T...N.....T.............sYG.TL.KFLITDMAAGFWHVK.....K.DGGT.G.FL.V......PST-KE.GGYIEFEGA.P.GQ.YTIT-n.........
A0A2Z3MZJ1_9BACT/827-907 ..............syv---------VLLADRVVSMSNS.RELINKGFSV.K..V.P...G.....-..............NA.AC.QIVLTGMAPGKWNIR.....G.GNSR.L.NV.N......TSVEAG.KNTIFLKAK.G.GT.YTI--sp........
A0A1M4WMJ5_9BACT/673-759 ................s-IENEKIVGAQLANRVVTFSKT.GQIIDRPFEL.E..V.T...G.....-..............NG.TF.KFVLTDLDAGTWQVK.....R.NGEV.Y.LP.G......IPVCSD.DGVMYFEGE.A.GD.YKFLR..........
A0A3B0BYU1_9BACL/1301-1386 .................MVDSDKMIGAAIADSVALFSKT.GDRENGTVSF.S..V.Y...G.....S..............RL.QL.HFVVTDMAAGSWAIM.....Q.GGQT.T.Y-.-......GEVTDD.GGVLYFDGQ.P.GS.YTLT-y.........
A0A1I1CI18_9BACL/1188-1273 ...............qt--DAAAMVGAQLADRAVLFSAS.GKRLSGIVTL.T..T.T...G.....S..............QA.NV.QYVVTDLQAGTWKIT.....G.NG--.V.ET.Y......GYVSEE.GGALYFTGA.P.GT.HTLTR..........
A0A374VCG6_9BACE/686-772 .................RIDAKRIIGVQIANRVVTFSKN.GEPVSGKFDI.T..I.N...G.....-..............NQ.TM.QFVLTDLVSGTWQIK.....K.DGKV.Y.IS.A......MEVRSD.DGILNFEGT.A.GH.YEFLR..........
A0A4S4BH90_9BACL/1030-1115 ................r-IETDDAAGVVIADRVVVFGKN.KLRTSADVEF.E..F.S...G.....-..............EG.EY.ELTVADLTAGTWTVE.....R.DGIT.M.D-.E......AIVTEE.GGVAVFHGE.P.GA.YRLS-y.........
A0A840CN47_9BACT/820-903 ..........etdnkyv---------ISLQDRIVCMSAG.YGQIQDSFSL.N..I.D...R.....-..............NT.EI.QILITDLKPGFWNIR.....N.METN.T.DR.N......FKVEAG.KNTIFFKGG.K.GK.YI---it........
D7VQL3_SPHSI/814-895 ...........agyyli----------RLDDRIVCISKG.GQLISEPIEL.T..V.P...A.....-..............DK.KY.KIILAGLKEGFWTIQ.....S.GQQV.S.DK.N......IPVDPG.KNVISFESQ.G.TA.L----rfa.......
A0A1I0V8D6_9BACL/1010-1097 ...............se---TDDYAGARIYDRVVFFAKD.FGLTDQEATI.A..F.D...G.....E..............AGqTY.KILVADLAEGDWTAV.....K.AGET.A.SA.K......HKVVKD.GNTLYFEGT.P.GT.YTLQ-k.........
A0A1I0V8D1_9BACL/729-814 ...........nakrhd--------GVMLRDRVVFFGYS.GERNTDTLKF.N..V.T...N.....T.............gPN.NL.KFLITDMAAGFWQVK.....R.DGEA.G.FL.V......RST-KE.GGFIEFEGA.P.GE.YTIT-n.........
F5IYN7_9BACT/814-894 ............nryil----------TLQDRIVCMSAD.YRQIQNPFTL.I..V.N...Q.....-..............DV.EF.QILVADLNPGFWHVC.....D.TGKN.I.DL.N......FKVEPG.KNTIFFKGG.K.GE.YY---ia........
A0A1Y5K6V9_9BACL/652-740 ................l-VEAGGAVGVQVQGWLVLFSRS.GLLLDGQLTI.A..A.D...E.....S..............GN.RR.KILVTDIANGLWLVH.....S.RSAD.G.KQrS......EQVDVT.EGVWLTEAA.A.GA.VQLE-r.........
A0A3B0BZF1_9BACL/650-739 ................k-VETEELVGAKIGGWVVLFAKS.GEALNREQYI.P..L.Y...A.....Eag..........eeAG.SW.SCFVADLAPGVWTVE.....T.GGTS.-.-E.A......HTVTEA.GGTLHLTGI.S.GS.VRL--vp........
A0A5S5CB74_9BACL/995-1082 ...............se---TDDYAGARIHDRVVLFAKD.FGLTDDEATI.T..F.S...G.....E.............aNQ.TY.KVLVADLAGGYWTAA.....K.EGES.A.SV.K......YQAVQE.GNTIYFEGT.P.GT.YVL--rk........
A0A120A2Q3_BACSE/687-773 .................RIDAEKVVGVQIADRVVTFSRD.SRPLSGKVDM.K..V.D...G.....-..............NA.AM.KFVITDLIPGTWQIK.....K.DGKV.Y.IP.A......MEVRSD.DGILSFEGT.A.GH.YEFLR..........
A0A098M3H4_9BACL/985-1072 .................MVDSGDMVGAKIADRVALFSKS.GDRLNGTVTL.N..I.S...G.....D..............ED.HL.QYVVTDLVAGYWTVE.....R.DGQT.A.DS.Q......LLVSEE.GGVLSFNGP.P.GT.YKLTW..........
A0A257I2B2_9BACT/674-758 ..............sng-----QYVAIAIADRIVAQALNlANNQSGEIAF.A..I.G...D.....T..............KK.SY.QVLITDLSPGKWLVQ.....SvNGKQ.I.--.-......FTVNKD.AGTIYFNSK.G.GK.FLLQ-k.........
A0A2V5KCG9_9BACL/689-777 ................q-INGDKVVGAQISDRVVLFAKD.GQPVNDELIF.E..I.P...G.....S..............DS.GL.YVLVTDLAAGYWTVQ.....R.QGSQpS.AV.Q......YEVLAD.KGILYFQGD.A.GT.YTLTR..........
A0A1K1N942_9BACL/950-1037 ...............se---TNDYAGARIHDRVVFFAKD.FDLVDQQATI.T..F.T...G.....Q.............tNQ.NY.KILVTDLEDGYWTAV.....K.QGGT.A.TV.K......YEAVQE.GNTIYFEGT.P.GT.YTLQ-k.........
A0A1K1N949_9BACL/1118-1205 ...............se---TADFAGARIYDRVVFFAKG.FDLIQNKATI.E..F.E...G.....D..............KDqKY.KILVTDLADGYWTAA.....K.KGKK.A.SV.K......YEVVKE.GNTLYFEGT.P.GT.YTLQ-k.........
A0A1K1PQC1_9BACL/926-1013 ...............se---TDDYAGARIQDRVVFFAKG.FDLIDQEATV.T..F.T...G.....E.............aNQ.TY.KILVADLEEGNWTAV.....K.EGET.A.AV.K......YQAVKE.GNTIYFEGT.P.GT.YTLQ-k.........
A0A3N4PA15_9BACT/824-902 .............hyql----------AIADRVVCMSAG.SGLIDRSFIM.K..A.P...A.....-..............-G.TR.QVTLAGLKGGYWHIR.....SaDGKI.N.-F.T......AAVADG.NNTLCFDAG.E.GH.-----itat......
A0A1I4M176_9BURK/868-955 ................a-VVSASMHGVKIDNRVVLFAKD.DADLSGTASF.E..L.A...T.....-..............AD.TL.RVLVTDLSQGYWSVS.....R.NGAP.A.TV.E......YEVGAE.DGTMYFVAAgA.GS.YTL--rq........
A0A1K1N9Z0_9BACL/1644-1729 ................r-LDSDRMVGVKVSGNAVWFSKD.SNRLDGAVTL.T..V.P...G.....D..............ET.NL.QFVVTDLEAGAWKIS.....R.DGVD.-.-T.S......GSVSEE.GGVLYFTGA.A.GT.YMLTR..........
A0A0M2WUR3_9BURK/848-936 .................AIDSALLAGVKIQDRVVLFSKS.GLPLGGTVTV.E..L.P...A.....Q..............SA.SM.QVLVTDLQAGSWTVI.....K.RGTD.G.PI.E......DEVSDG.GGTLYFVAN.G.GGvYDLQR..........
A0A2U1AP12_9BACT/969-1055 ...............lf--ESGTRIGVKVADRIVTFSKN.GRATADPVEF.T..V.P...A.....-..............GA.PR.QALLTDLLPGDYTVM.....R.DGKP.E.-R.N......ITVTEG.AGTLLLPVE.A.GRtYRV--is........
A0A1W2CNQ0_9SPHI/682-768 .................RIDGDKVVGVQLADRVVTFSRT.SETLDRGFTF.S..V.T...G.....-..............KG.TF.QFVITDLLPGTWQIL.....K.DGKV.F.KP.A......LSAKAD.DGSLYFTGT.E.GS.YRFLR..........
A0A4Q9DSQ0_9BACL/649-742 .................RVDCGNMTGVYVQDWVVMFSCS.GGLIGGTVHM.E..V.P...D.....S..............AG.PL.NMLVTDLQDGVWQVN.....Q.EQEL.P.SS.DteqlngTLIQTN.NGTLHLQGV.N.GG.IRLTR..........
A0A1V4HKR3_9BACL/850-940 ................s-IVSNEMVGVKIEDRAVLFSKS.GVDITNTASF.ElpV.S...N.....K..............DK.DV.RVLVTDLSTGYWTVT.....K.AGET.S.SV.E......YEVTPD.EGTLYFAAT.T.GGtYTLQ-h.........
A0A0M3CIX7_9SPHI/393-472 ..............yll----------HVADKIVYMSKG.KNLLDEIIHL.Q..I.P...A.....-..............GE.EK.EVIFAGVKEGFWNVS.....S.KDLT.V.NF.N......TIVDAG.KHVLSFRTT.G.GN.FTI--kl........
A0A1R3T3S2_9BACT/828-909 ...........ndkyil----------RLSDRILCMSSG.SQLIQSPFSM.T..V.S...D.....-..............DS.EY.QILLTDLKPGFWNIY.....S.PDKN.I.NL.N......FKVEQG.KNTCFFSAS.K.GL.YY---is........
A0A1W1ZZK8_9SPHI/817-902 .........setavsnv---------VIVGDRVVSMNKS.DKLIDKSFVL.N..I.P...E.....-..............KG.KY.QVVLTGMKAGEWNVT.....S.SDGK.V.KF.N......ANIKQD.KHTMFFIAA.K.GT.YTV--tp........
A0A1Y5KIG6_9BACL/1580-1665 ................k-LDSERMVGAKVAGNAVWFSKD.GNRLDGAVTL.T..V.P...G.....D..............DT.NL.QFVVTDLEAGSWKIS.....E.GGAD.T.--.F......GSVGEE.GGVLYFEGA.A.GA.YTLT-y.........
A0A5S5CKJ8_9BACL/1014-1101 ...............se---TEDYAGARIHDRVVFFAKG.FELVNQEAEF.T..F.T...G.....E..............ADqTY.KILVADLEEGNWTAV.....K.EGET.A.AV.K......YQVEKD.GNTLYFVGT.P.GT.YTLQ-k.........
A0A1I0YPU4_9BACL/1397-1483 ................r-LDADLMTGVQIADRAVWFSKS.GHRLNESVTL.S..V.Y...G.....S..............QA.DM.SVTIADMHAGKWKIS.....M.PGQT.D.-R.T......GVVSEE.GGVLAFSAP.A.GT.YTLT-p.........
A0A5C4SVN4_9BACL/1192-1279 .................AVDSERMVGAAIDDYVVLFGKS.GNKESGTVTF.A..T.Y...G.....P..............QP.AL.KYVIADLASGTWRIA.....K.TGET.E.PD.E......AEVGEE.GGVLYFTGA.P.GT.YTLT-y.........
A0A399CZW3_9BACT/835-917 ..........tkvsnvi----------IIADRVVSMSKG.NGFVEEEFTL.N..I.P...E.....-..............GL.KF.QIILTGMKAGSWNVK....sK.DGK-.M.KF.N......TTVRED.ENTIFFLAG.S.GE.YI---it........
A0A1W2APK4_9SPHI/686-772 .................RIDGDKVVGVQLADRVVTFSRT.SETIDRPFNF.S..V.A...G.....-..............KG.IF.KFVITDLLPGTWQVL.....K.DGKI.L.HP.A......LSVRSD.DGALYFEGT.E.GT.YRFLR..........
A0A3G9J2U5_9BACL/871-959 ................s-IVSNEMVGVKIEDRAVLFSKS.GVDITNTASF.E..L.P...V.....S..............NK.DV.RVLVTDLATGYWTVT.....K.AGET.S.SV.E......YEVTPD.EGTLYFAAN.T.GGtYTLQ-h.........
#=GC seq_cons ....................stthhGspluDRlVhFuKs.uphlspshol.s..l.s...u....................ps.sh.plllTDLpsGhWplp.....p.sGps.h.th.p......hpVsp-.sGsLaFpus.s.Gs.Ypl..h.........
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