GenomeNet

Database: Pfam
Entry: Herp-Cyclin
LinkDB: Herp-Cyclin
Original site: Herp-Cyclin 
#=GF ID   Herp-Cyclin
#=GF AC   PF09241.11
#=GF DE   Herpesviridae viral cyclin
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   pdb_1bu2
#=GF GA   25.00 25.00;
#=GF TC   26.20 238.60;
#=GF NC   23.50 18.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   10368294
#=GF RT   Crystal structure of a viral cyclin, a positive regulator of
#=GF RT   cyclin-dependent kinase 6. 
#=GF RA   Schulze-Gahmen U, Jung JU, Kim SH; 
#=GF RL   Structure. 1999;7:245-254.
#=GF DR   INTERPRO; IPR015322;
#=GF DR   SCOP; 1bu2; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Members of this family of viral cyclins adopt a helical
#=GF CC   structure consisting of five alpha-helices, with one helix
#=GF CC   surrounded by the others. They specifically activate CDK6 of
#=GF CC   host cells to a very high degree [1].
#=GF SQ   1
#=GS CGH2_SHV21/149-254  AC Q01043.1
#=GS CGH2_SHV21/149-254  DR PDB; 4TTH A; 149-254;
#=GS CGH2_SHV21/149-254  DR PDB; 1XO2 A; 149-254;
#=GS CGH2_SHV21/149-254  DR PDB; 1JOW A; 149-254;
#=GS CGH2_SHV21/149-254  DR PDB; 2F2C A; 149-254;
#=GS CGH2_SHV21/149-254  DR PDB; 1BU2 A; 149-250;
#=GS CGH2_SHV21/149-254  DR PDB; 2EUF A; 149-254;
CGH2_SHV21/149-254             AVLATDFLIPLCNALKIPEDLWPQLYEAASTTICKALIQPNIALLSPGLICAGGLLTTIETDNTNCRPWTCYLEDLSSILNFSTNTVRTVKDQVSEAFSLYDLEIL
#=GR CGH2_SHV21/149-254  SS    ---GGGGHHHHHHHTT--GGGHHHHHHHHHHHHHHHTTSGGGGGS-HHHHHHHHHHHHHHCS-TSSSTGHHHHHHHHHHHTCHHHHHHHHHHHHHHHHHTG-GGG-
#=GC SS_cons                   ---GGGGHHHHHHHTT--GGGHHHHHHHHHHHHHHHTTSGGGGGS-HHHHHHHHHHHHHHCS-TSSSTGHHHHHHHHHHHTCHHHHHHHHHHHHHHHHHTG-GGG-
#=GC seq_cons                  AVLATDFLIPLCNALKIPEDLWPQLYEAASTTICKALIQPNIALLSPGLICAGGLLTTIETDNTNCRPWTCYLEDLSSILNFSTNTVRTVKDQVSEAFSLYDLEIL
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