GenomeNet

Database: Pfam
Entry: Herpes_LMP1
LinkDB: Herpes_LMP1
Original site: Herpes_LMP1 
#=GF ID   Herpes_LMP1
#=GF AC   PF05297.11
#=GF DE   Herpesvirus latent membrane protein 1 (LMP1)
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_5174 (release 7.7)
#=GF GA   26.00 26.00;
#=GF TC   27.20 26.90;
#=GF NC   25.30 24.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12457963
#=GF RT   Characterization of the Cyno-EBV LMP1 homologue and comparison
#=GF RT   with LMP1s of EBV and other EBV-like viruses. 
#=GF RA   Faucher S, Dimock K, Wright KE; 
#=GF RL   Virus Res 2002;90:63-75.
#=GF DR   INTERPRO; IPR007961;
#=GF DR   SCOP; 1czy; fa;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several latent membrane protein 1 or
#=GF CC   LMP1s mostly from Epstein-Barr virus. LMP1 of EBV is a 62-65 kDa
#=GF CC   plasma membrane protein possessing six membrane spanning
#=GF CC   regions, a short cytoplasmic N-terminus and a long cytoplasmic
#=GF CC   carboxy tail of 200 amino acids. EBV latent membrane protein 1
#=GF CC   (LMP1) is essential for EBV-mediated transformation and has been
#=GF CC   associated with several cases of malignancies. EBV-like viruses
#=GF CC   in Cynomolgus monkeys (Macaca fascicularis) have been associated
#=GF CC   with high  lymphoma rates in immunosuppressed monkeys [1]
#=GF SQ   6
#=GS LMP1_EBVG/1-366             AC P0C741.1
#=GS LMP1_EBVA8/1-371            AC Q1HVB3.1
#=GS LMP1_EBVB9/1-386            AC P03230.1
#=GS LMP1_EBVB9/1-386            DR PDB; 1CZY E; 204-210;
#=GS LMP1_EBVB9/1-386            DR PDB; 1CZY D; 204-210;
#=GS A0A1Q9DPX0_SYMMI/1682-1974  AC A0A1Q9DPX0.1
#=GS A0A1Q9DVU0_SYMMI/218-550    AC A0A1Q9DVU0.1
#=GS A0A177CY40_9PLEO/5-202      AC A0A177CY40.1
LMP1_EBVG/1-366                        .........................................................MERDLERGPPGPPRPPLGPPLSSSIGLALLLLLLALLFWLYIVLSNWTGGALLVLYSFALMLIIIILII...FIFRRDLLCPLGGL..GLLLLMVTLLLIALWNLHGQA....LYLGIVLFIFGCLLVLGLWIYFLEILW...RLGATIWQLLAFILAFFLAIILLI..IAL.YLQQNW.....WTLLVDLLWLLLFMAILIWM...YFHGPRHTDEHHHDDSLPHPQQATDD.SSHESDSNSNEG.RHHL.LVSGAGDGPPLCSQNL...GAPGGGPDNGPQDPDNTDDNGPQDPDNTDDNG----------NTDDNGPQDPDNTDDNGPHDPLPHNPSDSAGNDGGPPNLTEEVENKGGDRGPPSMTDG----------GGGDPHLPTLLLGTSGSGGDDDDPHGPVQLSYYD.........................................................
LMP1_EBVA8/1-371                       .........................................................MEHDLERGPPGPRRPPRGPPLSSSLGLALLLLLLALLFWLYIVMSDWTGGALLVLYSFALILIIIILII...FIFRRDLLCPLGAL..CLLLLMITLLLIALWNLHGQA....LYLGIVLFIFGCLLVLGLWIYLLEILW...RLGATIWQLLAFFLAFFLDLILLI..IAL.YLQQNW.....WTLLVDLLWLLLFLAILIWM...YYHGQRHSDEHHHDDSLPHPQQATDD.SGHESDSNSNEG.RHHL.LVTGAGDGPPLCSQNL...GAPGGGPDNGPQDPDNTDDNGPQDPDNTDDNG-----PQDPDNTDDNGPQDPDNTADNGPHDPLPHNPSDSAGNDGGPPNLTEEVENKGGDRGPPSMTDG----------GGGDPHLPTLLLGTSGSGGDDDDPHGPVQLSYYD.........................................................
LMP1_EBVB9/1-386                       .........................................................MEHDLERGPPGPRRPPRGPPLSSSLGLALLLLLLALLFWLYIVMSDWTGGALLVLYSFALMLIIIILII...FIFRRDLLCPLGAL..CILLLMITLLLIALWNLHGQA....LFLGIVLFIFGCLLVLGIWIYLLEMLW...RLGATIWQLLAFFLAFFLDLILLI..IAL.YLQQNW.....WTLLVDLLWLLLFLAILIWM...YYHGQRHSDEHHHDDSLPHPQQATDD.SGHESDSNSNEG.RHHL.LVSGAGDGPPLCSQNL...GAPGGGPDNGPQDPDNTDDNGPQDPDNTDDNGPHDPLPQDPDNTDDNGPQDPDNTDDNGPHDPLPHSPSDSAGNDGGPPQLTEEVENKGGDQGPPLMTDGGGGHSHDSGHGGGDPHLPTLLLGSSGSGGDDDDPHGPVQLSYYD.........................................................
#=GR LMP1_EBVB9/1-386            SS    .........................................................XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXX....XXXXXXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXXXXXXXXXXXXXXXXXX..XXX.XXXXXX.....XXXXXXXXXXXXXXXXXXXX...XXXXXXXXXXXXXXXXXXX-EE-S--.XXXXXXXXXXXX.XXXX.XXXXXXXXXXXXXXXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.........................................................
A0A1Q9DPX0_SYMMI/1682-1974             eeteeagpptpdchqaptplrpssgnasrklredltkvaapsmssgasycccrragt-------------------------------------------------------SSSTVVLVVVVVVV...VVVVVVVVVVVVVL..VLVLVLVLVLVLVLVLVLVLV....LVLVLVLVLVLVLVLVLVLVLVLVLVL...VLVLVLVLVLVLVLVLVLVLV-LV..LVL.VLVLVL.....VLVLVLVLVLVLVLVLVLVL...HDHDHDHDHDHDHDHDHDHDHAVVLY.RNEDGEDQVDEE.RQEA.ALSPASKTP-------...------------------------------------------------------------------------------------------------------------------------------------------------salllaaydeieeiqevadasdadagpspvaeepaepseveealedgikeggpgqpl
A0A1Q9DVU0_SYMMI/218-550               ..........................................hliitiiitiaifvt-----------------------------------------------------VFFFFFFIIIIIIIIVsvtVIVTITRNATTTTI..LLLLLIIIIIIIIFTFIILTF....TFIIIVIVIVIVIVIVIINIIIICYLI...ITAIAINTIITIIIVIIIIIIIII..VFF.FFFFIFgfsfiFIVFVIIIVISMVLAAVVVV...AIEEVKSDDTERKVRKHCHPGHRCSG.NLHARSRPTGEAwQFHTyLQEKEKDKKKKKKSKSssdDSDSSEEDKKKKKADSSDDN---DSDDDDDEKEKEKSKEKADKDDESKSDDVEEVKPEDPSKKLEEEA----------------------------------------------------------------------------rkkaakaaeeaqaaaaklaaekaeaaarqkqresltkaaasaasaataaaa......
A0A177CY40_9PLEO/5-202                 ......................................................tie---------------------------------------------------------------------...--WRRRVLLPLWAIriCLLLVIVIGFSVAMGSNYDDArriiRYPAAVAFLFFTIVVLLLDVIQ-IILWtrdRLYPTYFAGLTIFQALFWGLVLLMdiVSIaNSQQSS.....RAVSLVVVIFLLYLGLFIYAlrgFLKQRRLSKQGHYTPANDAGAPAVAEiRYSESTFDRNDE.QHHS.PIYRGGD---------...------------------------------------------------------------------------------------------------------------------------------------------------lgeseplyaedeglvdry.......................................
#=GC SS_cons                           .........................................................XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXX....XXXXXXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXXXXXXXXXXXXXXXXXX..XXX.XXXXXX.....XXXXXXXXXXXXXXXXXXXX...XXXXXXXXXXXXXXXXXXX-EE-S--.XXXXXXXXXXXX.XXXX.XXXXXXXXXXXXXXXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.........................................................
#=GC seq_cons                          ..............................................................................................................VhaSFslhLIIIIlIl...hIaRRclLsPLsuL..sLLLLhlhlLlIALhslaspA....LaLuIVLFIFhsLlVLhlhIhlLplLW...RLusTIaplLshhLAhFLsLILLI..luL.aLQQsa.....aslLVslLhLLLaLAllIah...ahHspRHoD-HHHDcuhsHPppAss-.ssHES-ssoNEu.RHHh.LlosAGDsP.hpppp....susuut.Dpt.pcsDsoDDN...DsDssDDpt..........psD-stspDs-pstspsPpc.L.cps.....................................................................................................................................
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