GenomeNet

Database: Pfam
Entry: Herpes_LMP1
LinkDB: Herpes_LMP1
Original site: Herpes_LMP1 
#=GF ID   Herpes_LMP1
#=GF AC   PF05297.13
#=GF DE   Herpesvirus latent membrane protein 1 (LMP1)
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_5174 (release 7.7)
#=GF GA   26.00 26.00;
#=GF TC   26.40 26.90;
#=GF NC   25.30 25.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12457963
#=GF RT   Characterization of the Cyno-EBV LMP1 homologue and comparison
#=GF RT   with LMP1s of EBV and other EBV-like viruses. 
#=GF RA   Faucher S, Dimock K, Wright KE; 
#=GF RL   Virus Res 2002;90:63-75.
#=GF DR   INTERPRO; IPR007961;
#=GF DR   SCOP; 1czy; fa;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several latent membrane protein 1 or
#=GF CC   LMP1s mostly from Epstein-Barr virus. LMP1 of EBV is a 62-65 kDa
#=GF CC   plasma membrane protein possessing six membrane spanning
#=GF CC   regions, a short cytoplasmic N-terminus and a long cytoplasmic
#=GF CC   carboxy tail of 200 amino acids. EBV latent membrane protein 1
#=GF CC   (LMP1) is essential for EBV-mediated transformation and has been
#=GF CC   associated with several cases of malignancies. EBV-like viruses
#=GF CC   in Cynomolgus monkeys (Macaca fascicularis) have been associated
#=GF CC   with high  lymphoma rates in immunosuppressed monkeys [1]
#=GF SQ   7
#=GS LMP1_EBVA8/1-371            AC Q1HVB3.1
#=GS LMP1_EBVB9/1-386            AC P03230.1
#=GS LMP1_EBVB9/1-386            DR PDB; 1CZY E; 204-210;
#=GS LMP1_EBVB9/1-386            DR PDB; 1CZY D; 204-210;
#=GS Q66043_9GAMA/1-404          AC Q66043.2
#=GS A0A1Q9DPX0_SYMMI/1682-1974  AC A0A1Q9DPX0.1
#=GS A0A2K4C0H2_9STAP/77-407     AC A0A2K4C0H2.1
#=GS A0A1Q9DVU0_SYMMI/218-550    AC A0A1Q9DVU0.1
#=GS A0A177CY40_9PLEO/5-202      AC A0A177CY40.1
LMP1_EBVA8/1-371                       .........................................................MEHDLERGPPGPRRPPRGPPLSSSLGLALLLLLLALLFWLYIVMSDWTGGALLVLYSFALILIIIILII...FI....FRRDL..LCPLGAL..CLLLLMITLLLIALWNLHGQ...A....LYLGIVLFIFGCLLVLGLWIYLLEILW...RLGATIWQL.LAFFLAFFLDLILLI..IAL.YLQQNW.....WTLLVDLLWLLLFLAILIWM...YYHGQRHS........DEHHHDDSLPHPQQATD.D.SGHE.....SDSNSN...EG.RHHL.L.......VTGAGDG.PPLCSQNL...GAPGGGPDNGPQDPDNTDDNGPQDPDNTDDNG-----P.Q.DPDNTDDNGPQDPDNTADNGPHDPLPHNPSDSA......GNDGGPPNLTEEVEN.KGGDRGPPSMTDG----------GGGDP.HLPTLLL....GTSGSGGDDDDPHGPVQLSYYD.........................................................
LMP1_EBVB9/1-386                       .........................................................MEHDLERGPPGPRRPPRGPPLSSSLGLALLLLLLALLFWLYIVMSDWTGGALLVLYSFALMLIIIILII...FI....FRRDL..LCPLGAL..CILLLMITLLLIALWNLHGQ...A....LFLGIVLFIFGCLLVLGIWIYLLEMLW...RLGATIWQL.LAFFLAFFLDLILLI..IAL.YLQQNW.....WTLLVDLLWLLLFLAILIWM...YYHGQRHS........DEHHHDDSLPHPQQATD.D.SGHE.....SDSNSN...EG.RHHL.L.......VSGAGDG.PPLCSQNL...GAPGGGPDNGPQDPDNTDDNGPQDPDNTDDNGPHDPLP.Q.DPDNTDDNGPQDPDNTDDNGPHDPLPHSPSDSA......GNDGGPPQLTEEVEN.KGGDQGPPLMTDGGGGHSHDSGHGGGDP.HLPTLLL....GSSGSGGDDDDPHGPVQLSYYD.........................................................
#=GR LMP1_EBVB9/1-386            SS    .........................................................XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...XX....XXXXX..XXXXXXX..XXXXXXXXXXXXXXXXXXXX...X....XXXXXXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXXX.XXXXXXXXXXXXXXX..XXX.XXXXXX.....XXXXXXXXXXXXXXXXXXXX...XXXXXXXX........XXXXXXXXXXX-EE-S-.-.XXXX.....XXXXXX...XX.XXXX.X.......XXXXXXX.XXXXXXXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.X.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX......XXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXX....XXXXXXXXXXXXXXXXXXXXXX.........................................................
Q66043_9GAMA/1-404                     ......................................................meg-----NRGRGGGHRHPRCPQPHASLLFGSLLLLVAILVWFFIIMSDLTQTASTVLSSFAVVLIIIIIII...ML....FKRRL..LCPLGLL..CIILIMIVILVSNLLTLTGQ...T....LFVGLVILCLCILLALAVWFYLMWLLR...EYGASFWTI.LAFCLAFLLAIVFLI..IAV.LLHLAW.....FTVLVDLYWLLLFLAILIWI...YVHDFNRAipealanlEEEYNHQGHGHGGGQGD.E.HQPRvllisEDPKTHhhhHH.HHHH.K.......NSNQGDPlGPYVSQNG...GNGGNEGDGGNRDGGNGD-GGNGDGGNVGDGGNGNGGN.G.DGGNGDG-GNGDGGN--EGPDHLPYPIQATDGGnggegdGGNEGPDPLPYPIQAtDGGNGGQGDGGDGDGGNGGNGG-GGGDPdHLPHPIQatdgGNSGDGGDGGD-----------gedgegg..................................................
A0A1Q9DPX0_SYMMI/1682-1974             eeteeagpptpdchqaptplrpssgnasrklredltkvaapsmssgasycccrragt-------------------------------------------------------SSSTVVLVVVVVVV...VV....VVVVV..VVVVVVL..VLVLVLVLVLVLVLVLVLVL...V....LVLVLVLVLVLVLVLVLVLVLVLVLVL...VLVLVLVLV.LVLVLVLVLVLV-LV..LVL.VLVLVL.....VLVLVLVLVLVLVLVLVLVL...HDHDHDHD........HDHDHDHDHDHDHAVVL.Y.RNED.....GEDQVD...EE.RQEA.A.......LSPASKT.P-------...--------------------------------------.-.---------------------------------......---------------.----------------------------.-------....----------------------salllaaydeieeiqevadasdadagpspvaeepaepseveealedgikeggpgqpl
A0A2K4C0H2_9STAP/77-407                ..............dlkvverillalilpiiiliicmtafntyadsfillqpndlsv--------------------------------------------------------SISSIIIGQIVMA...FIvefgFRSYLqqIIEMKMN..TFFASIVVGVLFAIWNINMSfsmE....YTMYNVLYSFTFSLLVGELIRNTEGRT...IYIATIFHAaMSIPLVFLFNEELGN..VFA.MKVIAL.....ATTGVTVVYIALSLIIRLII...YLTTKRSL........DEVEENNYLDHVNDRSDnE.STLE.....SDNDDA...LN.ATST.YatteaqnTSQETDA.TPTNEATN...ETPNSSRDQNEQS-TETESNETVDTDHTETESTVQSTTdQtETDVPNEAETQPTDVTDNETTEETVTDN-----......---------------.----------------------------.-------....----------------------dddndaiqseinaahr.........................................
A0A1Q9DVU0_SYMMI/218-550               ..........................................hliitiiitiaifvt-----------------------------------------------------VFFFFFFIIIIIIIIVsvtVI....VTITR..NATTTTI..LLLLLIIIIIIIIFTFIILT...F....TFIIIVIVIVIVIVIVIINIIIICYLI...ITAIAINTI.ITIIIVIIIIIIIII..VFF.FFFFIFgfsfiFIVFVIIIVISMVLAAVVVV...AIEEVKSD........DTERKVRKHCHPGHRCS.G.NLHA.....RSRPTG...EAwQFHTyL.......QEKEKDK.KKKKKSKSssdDSDSSEEDKKKKKADSSDDN---DSDDDDDEKEKEKSK.E.KADKDDESKSDDVEEVKPEDPSKKLEEEA----......---------------.----------------------------.-------....----------------------rkkaakaaeeaqaaaaklaaekaeaaarqkqresltkaaasaasaataaaa......
A0A177CY40_9PLEO/5-202                 ......................................................tie---------------------------------------------------------------------...--....WRRRV..LLPLWAIriCLLLVIVIGFSVAMGSNYDD...ArriiRYPAAVAFLFFTIVVLLLDVIQ-IILWtrdRLYPTYFAG.LTIFQALFWGLVLLMdiVSIaNSQQSS.....RAVSLVVVIFLLYLGLFIYAlrgFLKQRRLS........KQGHYTPANDAGAPAVA.EiRYSE.....STFDRN...DE.QHHS.P.......IYRGGD-.--------...--------------------------------------.-.---------------------------------......---------------.----------------------------.-------....----------------------lgeseplyaedeglvdry.......................................
#=GC SS_cons                           .........................................................XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...XX....XXXXX..XXXXXXX..XXXXXXXXXXXXXXXXXXXX...X....XXXXXXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXXX.XXXXXXXXXXXXXXX..XXX.XXXXXX.....XXXXXXXXXXXXXXXXXXXX...XXXXXXXX........XXXXXXXXXXX-EE-S-.-.XXXX.....XXXXXX...XX.XXXX.X.......XXXXXXX.XXXXXXXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.X.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX......XXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXX....XXXXXXXXXXXXXXXXXXXXXX.........................................................
#=GC seq_cons                          ......................................................h..........................................................ShshllIllIlll...hl....a+ppl..lsslssl..sllLlhllllllslhslhsp...s....halslVlhlhhsllllhlhlhlh.hLh...hhssolapl.LshhLshhlslllLl..lsl.hh..sh.....hslhVsllhllLhLulllhh...ah+sp+ps........--cccspshsHstttss.-.ptp-.....u-ssss...-t.paHt.h.......hottuDs.s.h.ptp....tsssst.Dtt.pp.sps-.s...Dsspststt.......t.css.sst.tstsst....tssp..h..p..........................................................................................t....h..................................................
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