GenomeNet

Database: Pfam
Entry: Herpes_LMP2
LinkDB: Herpes_LMP2
Original site: Herpes_LMP2 
#=GF ID   Herpes_LMP2
#=GF AC   PF07415.12
#=GF DE   Gammaherpesvirus latent membrane protein (LMP2) protein
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_21212 (release 10.0)
#=GF GA   25.00 25.00;
#=GF TC   25.60 25.20;
#=GF NC   23.60 23.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11961256
#=GF RT   Epstein-Barr virus latent membrane protein 2B (LMP2B)
#=GF RT   co-localizes with LMP2A in perinuclear regions in transiently
#=GF RT   transfected cells. 
#=GF RA   Lynch DT, Zimmerman JS, Rowe DT; 
#=GF RL   J Gen Virol 2002;83:1025-1035.
#=GF DR   INTERPRO; IPR010881;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several Gammaherpesvirus latent membrane
#=GF CC   protein (LMP2) proteins. Epstein-Barr virus is a human
#=GF CC   Gammaherpesvirus that infects and establishes latency in B
#=GF CC   lymphocytes in vivo. The latent membrane protein 2 (LMP2) gene
#=GF CC   is expressed in latently infected B cells and encodes two
#=GF CC   protein isoforms, LMP2A and LMP2B, that are identical except for
#=GF CC   an additional N-terminal 119 aa cytoplasmic domain which is
#=GF CC   present in the LMP2A isoform. LMP2A is thought to play a key
#=GF CC   role in either the establishment or the maintenance of latency
#=GF CC   and/or the reactivation of productive infection from the latent
#=GF CC   state. The significance of LMP2B and its role in pathogenesis
#=GF CC   remain unclear [1].
#=GF SQ   3
#=GS LMP2_EBVA8/1-497    AC Q1HVJ2.1
#=GS Q57VY3_TRYB2/4-128  AC Q57VY3.1
#=GS LMP2_EBVB9/1-497    AC P13285.1
#=GS LMP2_EBVB9/1-497    DR PDB; 1UXW C; 1-9;
#=GS LMP2_EBVB9/1-497    DR PDB; 5GRG C; 1-6;
#=GS LMP2_EBVB9/1-497    DR PDB; 2JO9 B; 101-109;
#=GS LMP2_EBVB9/1-497    DR PDB; 5GRD C; 1-10;
LMP2_EBVA8/1-497               .....MGSLEMVPMGAGPPSPGGDPDGDDGGNNSQYPSASGSSGNTPTPPNDEERESNEEPPPPYEDPYWGNGDRHSDYQPLGTQDQSLYLGLQHDGNDGLPPPPYSPRDDSSQHIYEEAGRGSMNPVCLPVIVAPYLFWLAAIAASCFTASVSTVVTATGLALSLLLLAAVASSYAAAQRKLLTPVTVLTAVVTFFAICLTWRIEDPPFNSLLFALLAAAGGLQGIYVLVMLVLLILAYRRRWRRLTVCGGIMFLACVLVLIVDAVLQLSPLLGAVTVVSMTLLLLAFVLWLSSPGGLGTLGAALLTLAAALALLASLILGTLNLTTMFLLMLLWTLVVLLICSSCSSCPLSKILLARLFLYALALLLLASALIAGGSILQTNFKSLSSTEFIPNLFCMLLLIVAGILFILAILTEWGSGNRTYGPVFMCLGGLLTMVAGAVWLTVMTNTLLSAWILTAGFLIFLIGFALFGVIRCCRYCCYYCLTLESEERPPTPYRNTV.......
Q57VY3_TRYB2/4-128             ltkqm-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TKIKRKSAAVMWTNLTCTVLSFPAIVVLVVAWITSMVKTEWGFVHGFMCIVALLFVVASAALSILLHCKKPSTKIFFIQQLISLIAFALTAITLGMGHVTLYVCRQSEENEPP-------dctlqsv
LMP2_EBVB9/1-497               .....MGSLEMVPMGAGPPSPGGDPDGYDGGNNSQYPSASGSSGNTPTPPNDEERESNEEPPPPYEDPYWGNGDRHSDYQPLGTQDQSLYLGLQHDGNDGLPPPPYSPRDDSSQHIYEEAGRGSMNPVCLPVIVAPYLFWLAAIAASCFTASVSTVVTATGLALSLLLLAAVASSYAAAQRKLLTPVTVLTAVVTFFAICLTWRIEDPPFNSLLFALLAAAGGLQGIYVLVMLVLLILAYRRRWRRLTVCGGIMFLACVLVLIVDAVLQLSPLLGAVTVVSMTLLLLAFVLWLSSPGGLGTLGAALLTLAAALALLASLILGTLNLTTMFLLMLLWTLVVLLICSSCSSCPLSKILLARLFLYALALLLLASALIAGGSILQTNFKSLSSTEFIPNLFCMLLLIVAGILFILAILTEWGSGNRTYGPVFMCLGGLLTMVAGAVWLTVMSNTLLSAWILTAGFLIFLIGFALFGVIRCCRYCCYYCLTLESEERPPTPYRNTV.......
#=GR LMP2_EBVB9/1-497    SS    .....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---SS-----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.......
#=GC SS_cons                   .....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---SS-----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.......
#=GC seq_cons                  .....MGSLEMVPMGAGPPSPGGDPDG.DGGNNSQYPSASGSSGNTPTPPNDEERESNEEPPPPYEDPYWGNGDRHSDYQPLGTQDQSLYLGLQHDGNDGLPPPPYSPRDDSSQHIYEEAGRGSMNPVCLPVIVAPYLFWLAAIAASCFTASVSTVVTATGLALSLLLLAAVASSYAAAQRKLLTPVTVLTAVVTFFAICLTWRIEDPPFNSLLFALLAAAGGLQGIYVLVMLVLLILAYRRRWRRLTVCGGIMFLACVLVLIVDAVLQLSPLLGAVTVVSMTLLLLAFVLWLSSPGGLGTLGAALLTLAAALALLASLILGTLNLTTMFLLMLLWTLVVLLICSSCSSCPLSKILLARLFLYALALLLLASALIAGGSILQTNFKSLSSTEFIPNLFCMLLLIVAGILFILAILTEWGSGNRTYGPVFMCLGGLLTMVAGAVWLTVMoNTLLSAWILTAGFLIFLIGFALFGVIRCCRYCCYYCLTLESEERPPTPYRNTV.......
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