#=GF ID   Holin_BlyA
#=GF AC   PF05102.16
#=GF DE   holin, BlyA family
#=GF PI   holin_BlyA; 
#=GF AU   TIGRFAMs;
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   TIGRFAMs (release 2.0);
#=GF GA   27.00 27.00;
#=GF TC   32.20 32.10;
#=GF NC   26.90 24.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11073925
#=GF RT   Characterization of Borrelia burgdorferi BlyA and BlyB proteins:
#=GF RT   a prophage-encoded holin-like system. 
#=GF RA   Damman CJ, Eggers CH, Samuels DS, Oliver DB; 
#=GF RL   J Bacteriol 2000;182:6791-6797.
#=GF RN   [2]
#=GF RM   17897882
#=GF RT   Release of latent ClyA cytolysin from Escherichia coli mediated
#=GF RT   by a bacteriophage-associated putative holin (BlyA) from
#=GF RT   Borrelia burgdorferi.
#=GF RA   Ludwig A, von Rhein C, Mischke A, Brade V;
#=GF RL   Int J Med Microbiol. 2008;298:473-481.
#=GF DR   INTERPRO; IPR006493;
#=GF DR   TC; 1.E.17;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   BlyA, a small holin found in Borrelia circular plasmids that is
#=GF CC   encoded by a prophage.  BlyA contains two largely hydrophobic
#=GF CC   helices and a highly charged C-terminus and has two
#=GF CC   transmembrane segments [1].
#=GF SQ   4
#=GS O50906_BORBU/1-59  AC O50906.1
#=GS W6TX88_9SPIR/4-61  AC W6TX88.1
#=GS W6THN9_9SPIR/1-61  AC W6THN9.1
#=GS H7C7P6_BORBU/1-61  AC H7C7P6.1
O50906_BORBU/1-59             ..MDTI--LIFLSTIDNTKLIILGGFIVLVIMPMILAIKPQFRENLILLIQKLL.KN.INKKEKK...
W6TX88_9SPIR/4-61             in--TNNFIQLLLDIDGTKLLIISG----LILSTVLLIKPALKDILHILIEKFQsKN.KNKQNN-n..
W6THN9_9SPIR/1-61             ..MNTV--FDFLSNIAETKLIIIGIITLFILIPLALFLKPVLAEIVK-MIKHLL.KYlIDKQSK-nkk
H7C7P6_BORBU/1-61             ..MDTIKLTELLINLNEIKLIAVMIFVTVLVLGVLILLKPLLKDILTIVIGKIF.KN.GNGNGKN...
#=GC seq_cons                 ..MsTl..hphL.sIspTKLIIluhhhhhlllshlLhlKPhL+-ILpllIpKlh.KN.hNKpsK....
//