GenomeNet

Database: Pfam
Entry: HscB_4_cys
LinkDB: HscB_4_cys
Original site: HscB_4_cys 
#=GF ID   HscB_4_cys
#=GF AC   PF18256.2
#=GF DE   Co-chaperone HscB tetracysteine metal binding motif
#=GF AU   Smart A;0000-0002-6965-5633
#=GF SE   ECOD:EUF05121
#=GF GA   26.20 26.20;
#=GF TC   26.40 27.00;
#=GF NC   25.90 25.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   18713742
#=GF RT   Structure of human J-type co-chaperone HscB reveals a
#=GF RT   tetracysteine metal-binding domain.
#=GF RA   Bitto E, Bingman CA, Bittova L, Kondrashov DA, Bannen RM, Fox
#=GF RA   BG, Markley JL, Phillips GN Jr;
#=GF RL   J Biol Chem. 2008;283:30184-30192.
#=GF DR   INTERPRO; IPR040682;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is the N-terminal domain of human co-chaperone protein HscB
#=GF CC   (hHscB). This domain is capable of binding a metal ion through
#=GF CC   its tetracysteine metal binding motif. The metal atom is
#=GF CC   coordinated by a set of four cysteine residues (Cys41, Cys44,
#=GF CC   Cys58 and Cys61) on opposed beta-hairpins. Although the N-domain
#=GF CC   lacks any recognizable secondary structure elements, it has
#=GF CC   several distant structural homologs including C-4 zinc finger
#=GF CC   domains and rubredoxin [1].
#=GF SQ   109
#=GS A0A3Q7S991_VULVU/39-65  AC A0A3Q7S991.1
#=GS A0A226NB27_CALSU/31-57  AC A0A226NB27.1
#=GS HSC20_HUMAN/39-65       AC Q8IWL3.3
#=GS HSC20_HUMAN/39-65       DR PDB; 3BVO B; 40-65;
#=GS HSC20_HUMAN/39-65       DR PDB; 3BVO A; 39-65;
#=GS A0A2K5E0B1_AOTNA/39-65  AC A0A2K5E0B1.1
#=GS A0A2K5E058_AOTNA/39-65  AC A0A2K5E058.1
#=GS A0A401SXN2_CHIPU/54-81  AC A0A401SXN2.1
#=GS A0A2K5JEY7_COLAP/38-64  AC A0A2K5JEY7.1
#=GS G3RLQ2_GORGO/39-65      AC G3RLQ2.1
#=GS A0A2K6GT00_PROCO/39-65  AC A0A2K6GT00.1
#=GS A0A287AIR5_PIG/39-65    AC A0A287AIR5.1
#=GS G5APY5_HETGA/39-65      AC G5APY5.1
#=GS H2QLF2_PANTR/39-65      AC H2QLF2.1
#=GS A0A3Q7QXG1_VULVU/39-65  AC A0A3Q7QXG1.1
#=GS F6UZ83_CANLF/39-65      AC F6UZ83.1
#=GS A0A2Y9LCT4_DELLE/39-65  AC A0A2Y9LCT4.1
#=GS H2P3X7_PONAB/39-65      AC H2P3X7.1
#=GS A0A2R9ALN2_PANPA/39-65  AC A0A2R9ALN2.1
#=GS G1T125_RABIT/39-65      AC G1T125.1
#=GS A0A2K6BS85_MACNE/39-65  AC A0A2K6BS85.1
#=GS A0A286ZYP6_PIG/39-65    AC A0A286ZYP6.1
#=GS A0A2K5KQW6_CERAT/39-65  AC A0A2K5KQW6.1
#=GS A0A2Y9EJW7_PHYMC/39-65  AC A0A2Y9EJW7.1
#=GS L9KVN1_TUPCH/39-64      AC L9KVN1.1
#=GS A0A452RB25_URSAM/39-65  AC A0A452RB25.1
#=GS A0A2K5U2N1_MACFA/39-65  AC A0A2K5U2N1.1
#=GS A0A2Y9RRF0_TRIMA/1-15   AC A0A2Y9RRF0.1
#=GS A0A0R4J0T0_MOUSE/38-64  AC A0A0R4J0T0.1
#=GS A0A3Q7UJY9_URSAR/39-65  AC A0A3Q7UJY9.1
#=GS A0A226PZZ5_COLVI/31-57  AC A0A226PZZ5.1
#=GS A0A2Y9KZQ3_ENHLU/39-65  AC A0A2Y9KZQ3.1
#=GS A0A2R8M6R9_CALJA/39-65  AC A0A2R8M6R9.1
#=GS A0A2K6MBS0_RHIBE/39-65  AC A0A2K6MBS0.1
#=GS A0A3Q0DGD1_MESAU/38-64  AC A0A3Q0DGD1.1
#=GS A0A337SBL1_FELCA/39-65  AC A0A337SBL1.1
#=GS A0A2R9AGX8_PANPA/39-65  AC A0A2R9AGX8.1
#=GS W5NXH4_SHEEP/39-65      AC W5NXH4.1
#=GS G3HCC2_CRIGR/38-64      AC G3HCC2.1
#=GS M3YQ49_MUSPF/83-109     AC M3YQ49.1
#=GS A0A287D973_ICTTR/64-87  AC A0A287D973.1
#=GS A0A2K6MBR8_RHIBE/39-65  AC A0A2K6MBR8.1
#=GS D3ZME7_RAT/38-64        AC D3ZME7.1
#=GS A0A1A6GSF9_NEOLE/39-64  AC A0A1A6GSF9.1
#=GS A0A2I2Y6M1_GORGO/39-65  AC A0A2I2Y6M1.1
#=GS A0A1D5Q5I4_MACMU/39-65  AC A0A1D5Q5I4.1
#=GS B0QYH2_HUMAN/39-65      AC B0QYH2.1
#=GS H0VNQ0_CAVPO/39-65      AC H0VNQ0.1
#=GS A0A0Q3QRB4_AMAAE/35-61  AC A0A0Q3QRB4.1
#=GS A0A3Q7UVS7_URSAR/39-65  AC A0A3Q7UVS7.1
#=GS A0A452GZ03_9SAUR/36-62  AC A0A452GZ03.1
#=GS F1N857_CHICK/36-62      AC F1N857.3
#=GS A0A2K5KQU6_CERAT/39-65  AC A0A2K5KQU6.1
#=GS A0A2K5U2E7_MACFA/39-65  AC A0A2K5U2E7.1
#=GS F7BVB0_MONDO/34-60      AC F7BVB0.1
#=GS F8WBY7_HUMAN/39-65      AC F8WBY7.1
#=GS A0A2U3VX99_ODORO/39-65  AC A0A2U3VX99.1
#=GS A0A3Q2HTA2_HORSE/39-65  AC A0A3Q2HTA2.1
#=GS A0A3Q0E0F9_TARSY/39-65  AC A0A3Q0E0F9.1
#=GS A0A1S3F134_DIPOR/39-62  AC A0A1S3F134.1
#=GS A0A384BRZ0_URSMA/39-65  AC A0A384BRZ0.1
#=GS A0A1U7R3X1_MESAU/38-64  AC A0A1U7R3X1.1
#=GS L5L5C4_PTEAL/40-65      AC L5L5C4.1
#=GS A0A0D9RC58_CHLSB/40-65  AC A0A0D9RC58.1
#=GS A0A452C995_BALAS/39-65  AC A0A452C995.1
#=GS F6WGR2_HORSE/39-65      AC F6WGR2.1
#=GS H0WNV7_OTOGA/39-65      AC H0WNV7.1
#=GS A0A091DLD0_FUKDA/39-65  AC A0A091DLD0.1
#=GS G3STB6_LOXAF/39-66      AC G3STB6.1
#=GS D2H244_AILME/39-65      AC D2H244.1
#=GS F6UL52_MOUSE/1-13       AC F6UL52.1
#=GS A0A2Y9RZN5_TRIMA/39-66  AC A0A2Y9RZN5.1
#=GS A0A3Q7QXE7_VULVU/39-65  AC A0A3Q7QXE7.1
#=GS A0A2Y9E5W6_TRIMA/39-66  AC A0A2Y9E5W6.1
#=GS A0A2U3YD29_LEPWE/39-65  AC A0A2U3YD29.1
#=GS A0A337SF44_FELCA/39-65  AC A0A337SF44.1
#=GS F1MLK9_BOVIN/39-65      AC F1MLK9.1
#=GS A0A2K6TZH3_SAIBB/39-65  AC A0A2K6TZH3.1
#=GS A0A3Q7VC09_URSAR/39-65  AC A0A3Q7VC09.1
#=GS A0A2K5YRL0_MANLE/39-65  AC A0A2K5YRL0.1
#=GS A0A2J8QN89_PANTR/39-65  AC A0A2J8QN89.1
#=GS A0A2Y9KWY9_ENHLU/39-65  AC A0A2Y9KWY9.1
#=GS A0A2Y9SMC8_PHYMC/39-65  AC A0A2Y9SMC8.1
#=GS A0A3Q7TWW0_URSAR/39-65  AC A0A3Q7TWW0.1
#=GS F6VJ72_MACMU/39-65      AC F6VJ72.2
#=GS A0A2I2U3M8_FELCA/39-65  AC A0A2I2U3M8.1
#=GS A0A384BRQ1_URSMA/39-65  AC A0A384BRQ1.1
#=GS A0A452G4V6_CAPHI/39-65  AC A0A452G4V6.1
#=GS U3IRQ6_ANAPP/36-62      AC U3IRQ6.2
#=GS A0A096NRI2_PAPAN/39-65  AC A0A096NRI2.1
#=GS A0A2Y9RSL9_TRIMA/39-66  AC A0A2Y9RSL9.1
#=GS A0A2K5PJP0_CEBCA/39-65  AC A0A2K5PJP0.1
#=GS G1PUZ0_MYOLU/39-65      AC G1PUZ0.1
#=GS A0A2K6R0X8_RHIRO/39-65  AC A0A2K6R0X8.1
#=GS HSC20_MOUSE/38-64       AC Q8K3A0.2
#=GS A0A2Y9RVC7_TRIMA/39-66  AC A0A2Y9RVC7.1
#=GS A0A1S3A5G2_ERIEU/31-57  AC A0A1S3A5G2.1
#=GS A0A2K6GT17_PROCO/39-65  AC A0A2K6GT17.1
#=GS G1QPI3_NOMLE/39-65      AC G1QPI3.1
#=GS A0A2K6R106_RHIRO/39-65  AC A0A2K6R106.1
#=GS A0A2K5JEZ7_COLAP/38-64  AC A0A2K5JEZ7.1
#=GS A0A340XQC5_LIPVE/39-65  AC A0A340XQC5.1
#=GS F6UB25_CALJA/39-65      AC F6UB25.2
#=GS A0A2I3GGS7_NOMLE/39-65  AC A0A2I3GGS7.1
#=GS A0A383Z6Z2_BALAS/39-65  AC A0A383Z6Z2.1
#=GS A0A2K5YRL9_MANLE/39-65  AC A0A2K5YRL9.1
#=GS A0A3Q7VR91_URSAR/39-65  AC A0A3Q7VR91.1
#=GS A0A2Y9LHI9_DELLE/39-65  AC A0A2Y9LHI9.1
#=GS A0A2Y9LA55_DELLE/39-65  AC A0A2Y9LA55.1
#=GS A0A2R8MP53_CALJA/39-65  AC A0A2R8MP53.1
#=GS A0A096NRI1_PAPAN/39-65  AC A0A096NRI1.2
A0A3Q7S991_VULVU/39-65             s-QCWNCGG..PGGPTRGDGFFCPQCRALQ
A0A226NB27_CALSU/31-57             .PRCWSCGA..ALPGSDAVPHFCPRCRALQ
HSC20_HUMAN/39-65                  .PRCWNCGG..PWGPGREDRFFCPQCRALQ
#=GR HSC20_HUMAN/39-65       SS    .-B-SSS--..B--SS-S---B-TTT--B-
A0A2K5E0B1_AOTNA/39-65             .PRCWNCGS..PGGPGRENGFFCPQCRALQ
A0A2K5E058_AOTNA/39-65             .PRCWNCGS..PGGPGRENGFFCPQCRALQ
A0A401SXN2_CHIPU/54-81             g--CWRCGAerASGEQEAAAFFCPSCRALQ
A0A2K5JEY7_COLAP/38-64             .PRCWNCGG..PWGPGREDRFFCPQCRALQ
G3RLQ2_GORGO/39-65                 .PRCWNCGG..PWGPGREDRFFCPQCRALQ
A0A2K6GT00_PROCO/39-65             .PRCWNCGS..AGGPGQGDRFFCPQCRALQ
A0A287AIR5_PIG/39-65               .PRCWNCGG..LGGPLRGDQFFCPQCRALQ
G5APY5_HETGA/39-65                 .PRCWKCGS..PGAPARGHGLFCPQCRALQ
H2QLF2_PANTR/39-65                 .PRCWNCGG..PWGPGRDDRFFCPQCRALQ
A0A3Q7QXG1_VULVU/39-65             s-QCWNCGG..PGGPTRGDGFFCPQCRALQ
F6UZ83_CANLF/39-65                 s-QCWNCGG..PGGPTRGDGFFCPQCRALQ
A0A2Y9LCT4_DELLE/39-65             .PRCWNCGG..LGGPLRGDRFFCPQCRALQ
H2P3X7_PONAB/39-65                 .PSCWNCGG..PWGPGREDRFFCPQCRALQ
A0A2R9ALN2_PANPA/39-65             .PRCWNCGG..PWGPGRDDRFFCPQCRALQ
G1T125_RABIT/39-65                 .PGCWNCGV..PGAPGLGDGFFCPQCRALQ
A0A2K6BS85_MACNE/39-65             .PHCWNCGG..PWGPGREDRFFCPQCRALQ
A0A286ZYP6_PIG/39-65               .PRCWNCGG..LGGPLRGDQFFCPQCRALQ
A0A2K5KQW6_CERAT/39-65             .PHCWNCGG..PWDPGRENRFFCPQCRALQ
A0A2Y9EJW7_PHYMC/39-65             .PRCWNCGG..LGGPLRGDRFFCPQCRALQ
L9KVN1_TUPCH/39-64                 s-KCWDC-S..QEAPGVGDGFFCAQCRALQ
A0A452RB25_URSAM/39-65             .PQCWNCGG..PGGPMRGDGFFCPQCRALQ
A0A2K5U2N1_MACFA/39-65             .PHCWNCGG..PWGPGREDGFFCPQCRALQ
A0A2Y9RRF0_TRIMA/1-15              .--------..----MGEDVLFCPQCRALQ
A0A0R4J0T0_MOUSE/38-64             .PQCWNCGH..AREVGCGDEFFCSHCRALQ
A0A3Q7UJY9_URSAR/39-65             .PQCWNCGG..PGGPMRGDGFFCPQCRALQ
A0A226PZZ5_COLVI/31-57             .PRCWSCGA..ALPGSDAVPHFCPRCRALQ
A0A2Y9KZQ3_ENHLU/39-65             .PQCWNCGG..PGSPMRGDGFFCPQCRALQ
A0A2R8M6R9_CALJA/39-65             .PLCWNCGS..PGGPGRENGFFCPQCRALQ
A0A2K6MBS0_RHIBE/39-65             .PRCWNCGG..PWGSGREDRLFCPQCRALQ
A0A3Q0DGD1_MESAU/38-64             g-QCWNCGR..AGGVESGDGFFCEHCRALQ
A0A337SBL1_FELCA/39-65             .PQCWNCGG..PGVPKRGDGFFCPQCRALQ
A0A2R9AGX8_PANPA/39-65             .PRCWNCGG..PWGPGRDDRFFCPQCRALQ
W5NXH4_SHEEP/39-65                 .PRCWNCGG..AGGPPRGDRFFCPQCRALQ
G3HCC2_CRIGR/38-64                 g-QCWNCGS..AGGVESGDGFFCEHCRALQ
M3YQ49_MUSPF/83-109                .PQCWNCGG..PGSHMRGDGFFCPQCRALQ
A0A287D973_ICTTR/64-87             a-RCWNCGS..---LRRGNVFFCHQCRALQ
A0A2K6MBR8_RHIBE/39-65             .PRCWNCGG..PWGSGREDRLFCPQCRALQ
D3ZME7_RAT/38-64                   .PQCWNCGR..AMGAGRGDEFFCAHCRALQ
A0A1A6GSF9_NEOLE/39-64             .-QCWNCGS..AGGVESGDGFFCEHCRALQ
A0A2I2Y6M1_GORGO/39-65             .PRCWNCGG..PWGPGREDRFFCPQCRALQ
A0A1D5Q5I4_MACMU/39-65             .PHCWNCGG..PRGPGREDRFFCPQCRALQ
B0QYH2_HUMAN/39-65                 .PRCWNCGG..PWGPGREDRFFCPQCRALQ
H0VNQ0_CAVPO/39-65                 .PRCWKCGG..PGGPERGDGFFCPQCRALQ
A0A0Q3QRB4_AMAAE/35-61             .PRCWSCGS..ALPGDEGLPRFCPGCRALQ
A0A3Q7UVS7_URSAR/39-65             .PQCWNCGG..PGGPMRGDGFFCPQCRALQ
A0A452GZ03_9SAUR/36-62             .PRCWSCGI..PLSDRGGLPRFCPACQALQ
F1N857_CHICK/36-62                 .PRCWSCGG..ALSGADAAPHFCPRCRALQ
A0A2K5KQU6_CERAT/39-65             .PHCWNCGG..PWDPGRENRFFCPQCRALQ
A0A2K5U2E7_MACFA/39-65             .PHCWNCGG..PWGPGREDGFFCPQCRALQ
F7BVB0_MONDO/34-60                 .PSCWNCGS..QGAPLGGDVLFCSACRALQ
F8WBY7_HUMAN/39-65                 .PRCWNCGG..PWGPGREDRFFCPQCRALQ
A0A2U3VX99_ODORO/39-65             .PQCWNCGG..PGGPMRGHEFFCPQCRALQ
A0A3Q2HTA2_HORSE/39-65             s-GCWNCGS..PGGPVRGDGFFCPQCRALQ
A0A3Q0E0F9_TARSY/39-65             .PGCWNCGS..RGVPARGDGFFCPWCRALQ
A0A1S3F134_DIPOR/39-62             a-RCWHCGD..---TGRGDGFFCPRCRALQ
A0A384BRZ0_URSMA/39-65             .PQCWNCGG..PGGPMRGDGFFCPQCRALQ
A0A1U7R3X1_MESAU/38-64             g-QCWNCGR..AGGVESGDGFFCEHCRALQ
L5L5C4_PTEAL/40-65                 h--CWNCGG..PGGPLPGDGFFCPQCRALQ
A0A0D9RC58_CHLSB/40-65             h--CWNCGG..PWGPGREDRFFCPQCRALQ
A0A452C995_BALAS/39-65             .PRCWNCGG..LGGPLRGDRFFCPQCRALQ
F6WGR2_HORSE/39-65                 s-GCWNCGS..PGGPVRGDGFFCPQCRALQ
H0WNV7_OTOGA/39-65                 .PRCWNCGS..PGGPGRGDRFFCPQCRALQ
A0A091DLD0_FUKDA/39-65             .PRCWKCGS..PRGPARGDGLFCPQCSALQ
G3STB6_LOXAF/39-66                 .PRCWKCGG.sPGGPTGEDILFCPRCRALQ
D2H244_AILME/39-65                 .PQCWNCGG..PGGPMRGDGFFCPQCRALQ
F6UL52_MOUSE/1-13                  .--------..------GDEFFCSHCRALQ
A0A2Y9RZN5_TRIMA/39-66             .PRCWKCGG.sPGGPMGEDVLFCPQCRALQ
A0A3Q7QXE7_VULVU/39-65             s-QCWNCGG..PGGPTRGDGFFCPQCRALQ
A0A2Y9E5W6_TRIMA/39-66             .PRCWKCGG.sPGGPMGEDVLFCPQCRALQ
A0A2U3YD29_LEPWE/39-65             .PQCWNCGG..PGGPMREHGFFCPQCRALQ
A0A337SF44_FELCA/39-65             .PQCWNCGG..PGVPKRGDGFFCPQCRALQ
F1MLK9_BOVIN/39-65                 .PRCWNCGG..PGGPPRGDRFFCPQCRALQ
A0A2K6TZH3_SAIBB/39-65             .PSCWNCGS..PGGPGRENGFFCPQCRALQ
A0A3Q7VC09_URSAR/39-65             .PQCWNCGG..PGGPMRGDGFFCPQCRALQ
A0A2K5YRL0_MANLE/39-65             .PHCWNCGG..PWGSGREDRFFCPQCRALQ
A0A2J8QN89_PANTR/39-65             .PRCWNCGG..PWGPGRDDRFFCPQCRALQ
A0A2Y9KWY9_ENHLU/39-65             .PQCWNCGG..PGSPMRGDGFFCPQCRALQ
A0A2Y9SMC8_PHYMC/39-65             .PRCWNCGG..LGGPLRGDRFFCPQCRALQ
A0A3Q7TWW0_URSAR/39-65             .PQCWNCGG..PGGPMRGDGFFCPQCRALQ
F6VJ72_MACMU/39-65                 .PHCWNCGG..PRGPGREDRFFCPQCRALQ
A0A2I2U3M8_FELCA/39-65             .PQCWNCGG..PGVPKRGDGFFCPQCRALQ
A0A384BRQ1_URSMA/39-65             .PQCWNCGG..PGGPMRGDGFFCPQCRALQ
A0A452G4V6_CAPHI/39-65             .PRCWNCGG..AGGPPRGDRFFCPQCRALQ
U3IRQ6_ANAPP/36-62                 .PRCWSCGG..PVPGAAGLPHFCPSCRALQ
A0A096NRI2_PAPAN/39-65             .PHCWNCGG..PWGPGREDRFFCPQCRALQ
A0A2Y9RSL9_TRIMA/39-66             .PRCWKCGG.sPGGPMGEDVLFCPQCRALQ
A0A2K5PJP0_CEBCA/39-65             .PRCWNCGS..PGGPGRENGFFCPQCRALQ
G1PUZ0_MYOLU/39-65                 .PQCWNCGG..PGGPIREDGFFCPQCRALQ
A0A2K6R0X8_RHIRO/39-65             .PRCWNCGG..PWGSGREDRLFCPQCRALQ
HSC20_MOUSE/38-64                  .PQCWNCGH..AREAGCGDEFFCSHCRALQ
A0A2Y9RVC7_TRIMA/39-66             .PRCWKCGG.sPGGPMGEDVLFCPQCRALQ
A0A1S3A5G2_ERIEU/31-57             .PRCWSCGT..PGGPQGRDRLFCPQCRALQ
A0A2K6GT17_PROCO/39-65             .PRCWNCGS..AGGPGQGDRFFCPQCRALQ
G1QPI3_NOMLE/39-65                 .PRCWNCGG..PWGPRREDRFFCPQCRALQ
A0A2K6R106_RHIRO/39-65             .PRCWNCGG..PWGSGREDRLFCPQCRALQ
A0A2K5JEZ7_COLAP/38-64             .PRCWNCGG..PWGPGREDRFFCPQCRALQ
A0A340XQC5_LIPVE/39-65             .PRCWNCGG..LEGPLRGDRFFCPQCRALQ
F6UB25_CALJA/39-65                 .PLCWNCGS..PGGPGRENGFFCPQCRALQ
A0A2I3GGS7_NOMLE/39-65             .PRCWNCGG..PWGPRREDRFFCPQCRALQ
A0A383Z6Z2_BALAS/39-65             .PRCWNCGG..LGGPLRGDRFFCPQCRALQ
A0A2K5YRL9_MANLE/39-65             .PHCWNCGG..PWGSGREDRFFCPQCRALQ
A0A3Q7VR91_URSAR/39-65             .PQCWNCGG..PGGPMRGDGFFCPQCRALQ
A0A2Y9LHI9_DELLE/39-65             .PRCWNCGG..LGGPLRGDRFFCPQCRALQ
A0A2Y9LA55_DELLE/39-65             .PRCWNCGG..LGGPLRGDRFFCPQCRALQ
A0A2R8MP53_CALJA/39-65             .PLCWNCGS..PGGPGRENGFFCPQCRALQ
A0A096NRI1_PAPAN/39-65             .PHCWNCGG..PWGPGREDRFFCPQCRALQ
#=GC SS_cons                       .-B-SSS--..B--SS-S---B-TTT--B-
#=GC seq_cons                      .PpCWNCGG..PtGPtRsDtFFCPQCRALQ
//
DBGET integrated database retrieval system