GenomeNet

Database: Pfam
Entry: Htr2
LinkDB: Htr2
Original site: Htr2 
#=GF ID   Htr2
#=GF AC   PF17909.2
#=GF DE   Htr2 transmembrane domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF00795
#=GF GA   25.00 25.00;
#=GF TC   34.50 78.90;
#=GF NC   20.30 20.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   28165484
#=GF RT   New Insights on Signal Propagation by Sensory Rhodopsin
#=GF RT   II/Transducer Complex.
#=GF RA   Ishchenko A, Round E, Borshchevskiy V, Grudinin S, Gushchin I,
#=GF RA   Klare JP, Remeeva A, Polovinkin V, Utrobin P, Balandin T,
#=GF RA   Engelhard M, Buldt G, Gordeliy V;
#=GF RL   Sci Rep. 2017;7:41811.
#=GF RN   [2]
#=GF RM   23619282
#=GF RT   Ground state structure of D75N mutant of sensory rhodopsin II in
#=GF RT   complex with its cognate transducer.
#=GF RA   Ishchenko A, Round E, Borshchevskiy V, Grudinin S, Gushchin I,
#=GF RA   Klare JP, Balandin T, Remeeva A, Engelhard M, Buldt G, Gordeliy
#=GF RA   V;
#=GF RL   J Photochem Photobiol B. 2013;123:55-58.
#=GF DR   INTERPRO; IPR040913;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Archaebacterial photoreceptors mediate phototaxis by regulating
#=GF CC   cell motility through two-component signaling cascades like
#=GF CC   those found in chemotaxis signaling chains of enteric bacteria.
#=GF CC   The photoreceptor sensory rhodopsin II from N. pharaonis
#=GF CC   (NpSRII) in complex with its cognate transducer NpHtrII serves
#=GF CC   as a system for transmembrane signal transfer. This entry is for
#=GF CC   the transmembrane domain of the transducer HtrII. Studies
#=GF CC   suggest that conformation changes of the NpSRII/NpHtrII complex
#=GF CC   may be crucial for the mechanism of signal propagation spanning
#=GF CC   the membrane domain and feeding into the HAMP domain [1].
#=GF CC   Furthermore, HtrII in H. salinarum not only transmits the signal
#=GF CC   from the photoreceptor SRII but also operates as a chemoreceptor
#=GF CC   [2].
#=GF SQ   6
#=GS A0A1U7EZ33_NATPD/23-83  AC A0A1U7EZ33.1
#=GS M0LKB6_9EURY/21-84      AC M0LKB6.1
#=GS F8DBF1_HALXS/21-81      AC F8DBF1.1
#=GS L0AGQ4_NATGS/21-80      AC L0AGQ4.1
#=GS A0A346PLV0_9EURY/21-81  AC A0A346PLV0.1
#=GS A0A2Z2HYI9_9EURY/21-81  AC A0A2Z2HYI9.1
A0A1U7EZ33_NATPD/23-83             GATFAFVGALTVLFGAIAYGEVTAAAAT...GDAAAVQEAAVSAILGLIILLGINLGLVAATLG
M0LKB6_9EURY/21-84                 GAIFALVIAVTVAFGGAVYLEITAAIAEanaGGDANVGEVAVSAILGLIVLTVINLGLVASTVG
F8DBF1_HALXS/21-81                 GAIFALVIAVTLAFGGAAYLEVAAALES...GDAAAVGEAATSAILGLLVLTVINLGLVAATVG
L0AGQ4_NATGS/21-80                 GAIFALVIAVTIGFGGAVYLEITAALAD...-DPAVVGEVAVSGILGLIVLTVINLGLVAATVG
A0A346PLV0_9EURY/21-81             GTTFTLVVAVTLAFGWAMNAEVVAAVET...GEAAAVGDAATSAILGLVVLTVINLGLVAATVG
A0A2Z2HYI9_9EURY/21-81             GAIFTLVTIVTLAFGGVAYGDVAAALET...GDATAVAGASTSAILGLIVLTVINLGLVAATVG
#=GC seq_cons                      GAIFALVlAVTlAFGGAsYhEVsAAlto...GDAAAVGEAAsSAILGLIVLTVINLGLVAATVG
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