GenomeNet

Database: Pfam
Entry: IL23
LinkDB: IL23
Original site: IL23 
#=GF ID   IL23
#=GF AC   PF16649.5
#=GF DE   Interleukin 23 subunit alpha
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   PF00489
#=GF GA   27.00 27.00;
#=GF TC   31.60 29.70;
#=GF NC   25.80 22.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   18680750
#=GF RT   The structure of interleukin-23 reveals the molecular basis of
#=GF RT   p40 subunit sharing with interleukin-12.
#=GF RA   Lupardus PJ, Garcia KC;
#=GF RL   J Mol Biol. 2008;382:931-941.
#=GF RN   [2]
#=GF RM   18708069
#=GF RT   Crystal structures of the pro-inflammatory cytokine
#=GF RT   interleukin-23 and its complex with a high-affinity neutralizing
#=GF RT   antibody.
#=GF RA   Beyer BM, Ingram R, Ramanathan L, Reichert P, Le HV, Madison V,
#=GF RA   Orth P;
#=GF RL   J Mol Biol. 2008;382:942-955.
#=GF RN   [3]
#=GF RM   22325775
#=GF RT   Structures of adnectin/protein complexes reveal an expanded
#=GF RT   binding footprint.
#=GF RA   Ramamurthy V, Krystek SR Jr, Bush A, Wei A, Emanuel SL, Das
#=GF RA   Gupta R, Janjua A, Cheng L, Murdock M, Abramczyk B, Cohen D, Lin
#=GF RA   Z, Morin P, Davis JH, Dabritz M, McLaughlin DC, Russo KA, Chao
#=GF RA   G, Wright MC, Jenny VA, Engle LJ, Furfine E, Sheriff S;
#=GF RL   Structure. 2012;20:259-269.
#=GF DR   INTERPRO; IPR010831;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This family, interleukin 23 subunit alpha, is a heterodimer
#=GF CC   consisting of a 40 kDa subunit - p40 - that is shared with IL12
#=GF CC   and a unique 19 kDa subunit - p19. IL23 is a pro-inflammatory
#=GF CC   cytokine that binds to adnectins and thus plays a key role in
#=GF CC   the pathogenesis of several autoimmune and inflammatory
#=GF CC   diseases. IL23 signalling on the cell membrane works through the
#=GF CC   interaction of four proteins, two of which are shared with the
#=GF CC   IL12-receptor complex; signalling through the cell membrane
#=GF CC   involves the combined aggregation of at least two receptor
#=GF CC   components and then the subsequent activation of the Jak/Tyk
#=GF CC   tyrosine kinases and the family of STAT transcription factors
#=GF CC   [1,2,3].
#=GF SQ   48
#=GS A0A0D9QYP7_CHLSB/28-184  AC A0A0D9QYP7.1
#=GS I3MQP8_ICTTR/28-180      AC I3MQP8.1
#=GS A0A2D0SHA0_ICTPU/34-177  AC A0A2D0SHA0.1
#=GS IL23A_MOUSE/28-185       AC Q9EQ14.1
#=GS G3HRP0_CRIGR/28-185      AC G3HRP0.1
#=GS G1LB13_AILME/34-191      AC G1LB13.1
#=GS H2Q687_PANTR/28-184      AC H2Q687.1
#=GS F1PV83_CANLF/31-188      AC F1PV83.2
#=GS G1SSM0_RABIT/28-186      AC G1SSM0.2
#=GS A0A0G2L2G7_DANRE/30-176  AC A0A0G2L2G7.1
#=GS S7NAB8_MYOBR/31-190      AC S7NAB8.1
#=GS A0A1U7UI57_TARSY/28-184  AC A0A1U7UI57.1
#=GS G1P7R9_MYOLU/30-189      AC G1P7R9.1
#=GS H2NHP9_PONAB/28-184      AC H2NHP9.1
#=GS G3TE23_LOXAF/29-186      AC G3TE23.1
#=GS IL23A_CAVPO/28-184       AC Q6LA37.1
#=GS M3WG71_FELCA/34-191      AC M3WG71.2
#=GS IL23A_PIG/31-188         AC Q9N2H9.1
#=GS M3XQN3_MUSPF/33-190      AC M3XQN3.1
#=GS A0A1S3ADS1_ERIEU/29-186  AC A0A1S3ADS1.1
#=GS IL23A_HORSE/30-187       AC Q64FU1.1
#=GS A0A1U7SP30_ALLSI/1-127   AC A0A1U7SP30.1
#=GS H0XNV0_OTOGA/28-185      AC H0XNV0.1
#=GS A0A2K5KGZ8_COLAP/28-195  AC A0A2K5KGZ8.1
#=GS A0A1A6GZN1_NEOLE/85-134  AC A0A1A6GZN1.1
#=GS IL23A_RAT/28-185         AC Q91Z84.1
#=GS G7PIH8_MACFA/28-184      AC G7PIH8.1
#=GS A0A2K5KH01_COLAP/28-184  AC A0A2K5KH01.1
#=GS L5KWB6_PTEAL/28-185      AC L5KWB6.1
#=GS A0A1V4JCR9_PATFA/31-177  AC A0A1V4JCR9.1
#=GS A0A091CXP4_FUKDA/28-184  AC A0A091CXP4.1
#=GS A0A1S3FIG4_DIPOR/29-186  AC A0A1S3FIG4.1
#=GS F6V356_ORNAN/27-159      AC F6V356.1
#=GS T0NJP2_CAMFR/29-186      AC T0NJP2.1
#=GS IL23A_HUMAN/28-184       AC Q9NPF7.1
#=GS IL23A_HUMAN/28-184       DR PDB; 5NJD L; 28-184;
#=GS IL23A_HUMAN/28-184       DR PDB; 3DUH C; 9-165;
#=GS IL23A_HUMAN/28-184       DR PDB; 3D85 C; 9-165;
#=GS IL23A_HUMAN/28-184       DR PDB; 3D87 C; 9-165;
#=GS IL23A_HUMAN/28-184       DR PDB; 4GRW C; 9-165;
#=GS IL23A_HUMAN/28-184       DR PDB; 3DUH D; 9-165;
#=GS IL23A_HUMAN/28-184       DR PDB; 5NJD F; 28-184;
#=GS IL23A_HUMAN/28-184       DR PDB; 4GRW A; 9-165;
#=GS IL23A_HUMAN/28-184       DR PDB; 5NJD B; 28-184;
#=GS IL23A_HUMAN/28-184       DR PDB; 5MXA B; 28-184;
#=GS IL23A_HUMAN/28-184       DR PDB; 5MZV B; 28-184;
#=GS IL23A_HUMAN/28-184       DR PDB; 3D87 A; 9-165;
#=GS IL23A_HUMAN/28-184       DR PDB; 5NJD H; 28-184;
#=GS IL23A_HUMAN/28-184       DR PDB; 5MJ3 B; 28-184;
#=GS IL23A_HUMAN/28-184       DR PDB; 3QWR B; 9-165;
#=GS IL23A_HUMAN/28-184       DR PDB; 5MJ4 B; 28-184;
#=GS IL23A_HUMAN/28-184       DR PDB; 5NJD D; 28-184;
#=GS IL23A_HUMAN/28-184       DR PDB; 5NJD J; 28-184;
#=GS W5PHK6_SHEEP/28-185      AC W5PHK6.1
#=GS F1MSN4_BOVIN/35-192      AC F1MSN4.2
#=GS G3QH19_GORGO/28-184      AC G3QH19.2
#=GS G5BB75_HETGA/28-184      AC G5BB75.1
#=GS A0A151ND31_ALLMI/1-123   AC A0A151ND31.1
#=GS F7HQI5_MACMU/28-184      AC F7HQI5.1
#=GS A0A2K5LDE9_CERAT/28-184  AC A0A2K5LDE9.1
#=GS A0A1A6GZN1_NEOLE/28-87   AC A0A1A6GZN1.1
#=GS A0A096NH07_PAPAN/28-184  AC A0A096NH07.1
#=GS F7H1B4_CALJA/28-184      AC F7H1B4.1
#=GS A0A1U7QS90_MESAU/28-185  AC A0A1U7QS90.1
#=GS G3VET0_SARHA/31-186      AC G3VET0.1
#=GS G1S6V2_NOMLE/28-184      AC G1S6V2.1
A0A0D9QYP7_CHLSB/28-184             ...........................PAWAQCQQLSQKLCTLAWSAHPLVGHMDL-RE..EGDEETT.NDVP.HIQCGDGCDPQGLRDNSQ...........FCLQRIRQGLIFYEKLLG.SD.IFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSPSPSQPWQR.LLLRFKILRSLQAFVAVAARVFAHGA......
I3MQP8_ICTTR/28-180                 ...........................PSWAQCQELSQKLCTLLWRAHPLVGHMDLLRE..EGEEETT.NDVP.HIQCGDGCDPQGLKDNSQ...........FCLQRIHQGLIFYEKLLG.SD.IFTGD-----DAPVGQLHASLLGLSQLLQPEGHHLETQQTPNPSPSQPWQR.LLLRFKILRSLQAFIAVAARVFAHGA......
A0A2D0SHA0_ICTPU/34-177             tlvlglnekarqlyqevetpsevaavs--------------------------------..-------.-DPPlMIRAEDKCDPDSLKTNPE...........TCLSRVVLALKNYSRIFGeSG.IFQGQNTKCDKWRANAT-AIAVVTEQILEALKEPSE---TPTPMMMANWMTeGYLCRDSVERLYSFSIMTARVFSH--ls....
IL23A_MOUSE/28-185                  ...........................PDWAQCQQLSRNLCMLAWNAHAPAGHMNLLRE..EEDEETK.NNVP.RIQCEDGCDPQGLKDNSQ...........FCLQRIRQGLAFYKHLLD.SD.IFKGEPALLPDSPMEQLHTSLLGLSQLLQPEDHPRETQQMPSLSSSQQWQR.PLLRSKILRSLQAFLAIAARVFAHGA......
G3HRP0_CRIGR/28-185                 ...........................PDWAQCQQLSRSLCTLAWDAHPPVGHMDTLRE..EGNEETR.SDVP.HIQCGDGCDPQGLKDNSQ...........FCLQRIHQGLVFYKQLLD.SD.IFTGEPSLLPDGPVGQLHTSLLGLSQLLQPEDHQWESQQMPSLSPSQQWQR.PLLRSKILRSLQAFVAIAARVFAHGA......
G1LB13_AILME/34-191                 ...........................PAWVQGQQLSQRLCTLAWSAHPPMGQVDLPRE..EGDDETT.DEVP.RIQCGDGCDPQGLRDNSQ...........FCLQRIHQGLVFYEKLLG.SD.IFTGEPFLLPDGPVGQLHASLLGLRQLLQPEGHHRETEQTPSPSPSQPWQR.LLLRFKILRSLQAFVAVAARVFAHGA......
H2Q687_PANTR/28-184                 ...........................PAWTQCQQLSQKLCTLAWSAHPLVGHMDL-RE..EGDEETT.NDVP.HIQCGDGCDPQGLRDNSQ...........FCLQRIHQGLIFYEKLLG.SD.IFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQR.LLLRFKILRSLQAFVAVAARVFAHGA......
F1PV83_CANLF/31-188                 ...........................PAWIQGQQLSQKLCTLVWSAHPPMGHVDLPRE..EGDGETT.SDVP.RIQCGDGCDPQGLKDNSQ...........FCLQRIHQGLVFYEKLLG.SD.IFTGEPSLLPDGPVGQLHANLLGLRQLLQPEGHHWETEQTPSPSPSQPWQR.LLLRLKILRSLQAFVAVAARVFAHGA......
G1SSM0_RABIT/28-186                 ...........................PAWTQCQQLSQKLCTLAWSAHPQMGPMELLRE..EGDEETTsDDVP.HIQCEDGCDPQGLRDNTQ...........FCLQRIRQGLFFYEKLLG.SD.IFTGEPALLPDGPVGQLHASLLGLSQLLQPEGHHRETPQTPSLHPSQPWQR.RLLRFKILRSLQAFLAVAARVFAHGA......
A0A0G2L2G7_DANRE/30-176             ........................vnf---RECKRLSIHLVEMARDLYNKV---ESPK-..-MTSVIT.DLPV.TIRPNDTCDPQSLQSNKK...........TCQSRIILALKNYSRIFH.KDgIFNKSACSKWRVNAEQIANVTGHLLKVLK-------ESAVHAPWTAEDWND.DFLCRDSVERLYSFSIISARVFSY--la....
S7NAB8_MYOBR/31-190                 ...........................PAWARCQQLSQRLCTLAWSAHPPTEHVDLPREagEEEDETT.NDVP.HIQCEDGCDPQGLRDNSQ...........SCLQRIHQGLVFYEKLLG.SD.IFTGEPSLLPDGPVSQLHASLLGLRQLLQTEGHHWATEQTPSLSPSQPWQR.LLLRPKILRSLQAFVAVAARVFAHGA......
A0A1U7UI57_TARSY/28-184             ..........................l-SWAQCQQLSQKLCTLAWSAHPPVGHTDL-RE..EGDEETT.SDVP.HIQCADGCDPQGLKDNSQ...........FCLQRIHQGLIFYEKLLG.SD.IFTGEPSLLPDGPVGQLHASLLGLSQLLQPEGYHRESQQILHPSPSQPWQR.LLLRFKILRSLQAFVAVAARVFAHGA......
G1P7R9_MYOLU/30-189                 ...........................PAWARCQQLSQRLCTLAWRAHPPTGHVDLPREvgEEEDETT.NDVP.HIQCEDGCDPQGLRDNSQ...........SCLQRIHQGLVFYEKLLG.SD.IFTGEPSLLPDGPVSQLHASLLGLRQLLQTEGHHWATEQTPSLSPSQPWQR.LLLRPKILRSLQAFVAVAARVFAHGA......
H2NHP9_PONAB/28-184                 ...........................PAWAQCQQLSQKLCTLAWSAHPLVGHMDL-RE..EGDEETT.NDVP.HIQCGDGCDPQGLRDNSQ...........FCLQRIHQGLIFYEKLLG.SD.IFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQR.LLLRFKILRSLQAFVAVAARVFAHGA......
G3TE23_LOXAF/29-186                 ...........................PAWAQGQQLSQKLCMLAWSAHPSIAHVDVPRE..EGDDETT.SEVP.RIQCWDGCDPQGLRDNSQ...........FCLQRIHQGLIFYEKLLG.SD.IFRGEPSLLPDGPVGQLHASLLGLSQLLQPEGHHSETQPTPTPSPSLPWQR.LLLRLKILRSLQAFVAVAARVFAHGA......
IL23A_CAVPO/28-184                  ...........................PSWTQCQQLSQKLCTLAWSAHPSVGHVEPPRE..EADEETT.DYVP.HILCGDGCDPQGLKDNSQ...........FCLQRIYQGLVFYQNLLG.SD.IFTGEPPLFPDGPVSQLHASLLGLSQLLQPEVHQWE-PQIPSLSPNQPWQR.LLLRIKILRSFQAFVAVAARVFGHGA......
M3WG71_FELCA/34-191                 ...........................PAWALGQQLSQKLCTLAWSAHPPTGHVDLPRE..QGDDETT.DDVP.HIQCGDGCDPQGLRDNSQ...........FCLQRIHQGLVFYEKLLG.SD.IFTGEPSLLPDSPVGQLHASLLGLRQLLQPDGQHWETEQTPNPSPNQPWQR.LLLRFKILRSLQAFVAVAARVFAHGA......
IL23A_PIG/31-188                    ...........................PAWAQGQQLSQQLCTLAWTAHLPMGHVDLPRE..EGDDETT.SEVP.HIQCGDGCDPQGLRDNSQ...........SCLQRIHQGLVFYEKLLG.SD.IFTGEPSLHPDGSVGQLHASLLGLRQLLQPEGHHWETEQTPSPSPSQPWQR.LLLRLKILRSLQAFVAVAARVFAHGA......
M3XQN3_MUSPF/33-190                 ...........................PAWVRGQQLSQQLCTLAWGTHPPMGHVDLPRE..EEDDETT.QEVP.RIQCGDGCDPQGLEDNSQ...........FCLQRIHQGLVFYEKLLG.SD.IFTGEPSPLPDGPVGQLHASLLGLRQLLQPEVHHWETEQTPSPSPSQPWQR.LLLRFKILRSLQAFVAVAARVFAHGA......
A0A1S3ADS1_ERIEU/29-186             ...........................PAWGQCQQLSQKLCTLAWSAHSPMEHVDLPRE..EGDDETA.DDVP.HIQCGDGCDPQGLKDNSQ...........YCLQRIHQGLVFYEKLLG.SD.IFTGEPSLLPNGPVEQLHASLLGLRQLLQTNGRPGETEQTPSPSPSQPWQR.LLLRFKILRSLQAFVAVAARVFAHGA......
IL23A_HORSE/30-187                  ...........................PAWAQCQQLSQKLCTLAWSAHPPMGHVDLPRE..EGDAETT.NDVP.HIQCEDGCDPEGLRDNSQ...........PCLQRIHQGLVFYEKLLG.SD.IFTGEPSLLPNGPVDQLHASLLGLRQLLQPEGHHWETEQIPSPSPSQPWQR.LLLRPKILRSLQAFVAVAARVFAHGA......
A0A1U7SP30_ALLSI/1-127              ....................meeqmel--------------------------------..QEQEPGQ.DPTP.RIRCSDGCDPGALSTDSS...........HCLGRIWQGLQHYRALLG.SE.LFAGRS------RAPDLEDALAQLSHLLQRPGEGDAELWRPTLEPSLIWAR.GIIQHRTLRQLQAFSAVIARVFAHGA......
H0XNV0_OTOGA/28-185                 ...........................PAWARGQQLSQKLCTLAWSAHPPVGHMDLLRE..EGNEETT.NDVP.HIQCEDGCDPQGLKDNSQ...........FCLQRIHQGLLFYEKLLG.SD.IFTGEPPLLPDGPVGQLHASLLGLSQLLQPEGHHWEPQHTASPIPSQPWQR.LLLRFKILRSLQAFVAVAARVFAHGA......
A0A2K5KGZ8_COLAP/28-195             ...........................PAWAQCQQLSQKLCTLAWSAHPLVGHMDL-RE..EGDEETT.NDVP.HIQCGDGCDPQGLRDNSQarglrtwlgtmFCLQRIRQGLIFYEKLLG.SD.IFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSPSPSQPWQR.LLLRFKILRSLQAFVAVAARVFAHGA......
A0A1A6GZN1_NEOLE/85-134             ..........................s--------------------------------..-------.----.------------------...........------------------.--.----------------------------QPKDHHWESQQMPRLSPSQQWQR.PLLRSKILRSLQAFVAIAARVFAHGA......
IL23A_RAT/28-185                    ...........................PDWAQCQQLSRNLCTLAWSAHTPVGQMDLLRE..EGEEETK.SDVP.RIQCGDGCDPQGLKDNSQ...........FCLQRIRQGLVFYKHLLD.SD.IFTGEPSLLPDSPVDQLHTSLLGLSQLLQPEDHHWETQQMPRLSPSQQWQR.SLLRSKILRSLQAFLAIAARVFAHGA......
G7PIH8_MACFA/28-184                 ...........................PAWAQCQQLSQKLCTLAWSAHPLVGHMDL-RE..EGDEETT.NDVP.HIQCGDGCDPQGLRDNSQ...........FCLQRIRQGLIFYEKLLG.SD.IFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSPSPSQPWQR.LLLRFKILRSLQAFVAVAARVFAHGA......
A0A2K5KH01_COLAP/28-184             ...........................PAWAQCQQLSQKLCTLAWSAHPLVGHMDL-RE..EGDEETT.NDVP.HIQCGDGCDPQGLRDNSQ...........FCLQRIRQGLIFYEKLLG.SD.IFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSPSPSQPWQR.LLLRFKILRSLQAFVAVAARVFAHGA......
L5KWB6_PTEAL/28-185                 ...........................PAWAQCQQLSQKLCTLAWSAHPPMGHVDLPRE..EGDDETT.NDVP.HIQCEDGCDPQGLRVNSQ...........SCLQRIHQGLVFYERLLG.SD.IFTGEPSLLSSGPVIQLHASLLGLRQLLQPEEHHWETEQTPSPSPSQPWQR.LLLRLKILRSLQAFVAIAARVFAHGA......
A0A1V4JCR9_PATFA/31-177             ..........................t-DWVACRSLSRELSRLVATLKEPHRVLEE-TQ..LSEEDPK.NWPP.RIRCSDACDPSTLDTNNT...........RCLQRILQGLQHYRDLLG.SD.IFTARRLPRLEATLDQ----LLGLV---QQ-EHGRP--PRHSLAPTETWAH.PLLQRMALQRLQSFVAIMSRVFTHSA......
A0A091CXP4_FUKDA/28-184             ...........................PAWAQCQQLSQKLCTLAWSAHPSVGHVDPPRE..EGDEETA.DDVP.HILCGDGCDPQGLKDNSE...........FCLQKIYQGLIFYQKLLG.SD.IFTGEPSLLPDGPVGQLHASLVGLSQLLQPEDHRWE-TQTPSLNPSQPWQR.LLLRIKILRSLQAFVAVAARVFAHGA......
A0A1S3FIG4_DIPOR/29-186             ...........................PAWDQCQKLSQKICTLAWNAHSPVGHMDLLRE..EEDEETT.DEVP.HIQCGDGCDPQGLRDNSQ...........FCLQRIHQGLVFYEKLLG.SD.IFTGEPFLLPDGPVRQLHASLLGLSQLLPPEGHHWEIQQIPIPSSSQPWQR.PLLRIKILRSLQAFVAVAARVFSHGA......
F6V356_ORNAN/27-159                 ..........................l-AWGQCQQLAQSITTLAWGIRPLGEHMEMPRE..EGERKAE.DPTP.QIQCSDRCDPDGLGSDGE...........LCLRRLQEALTFYGHLLG.SD.LFSGQP---QPGPVGQLRSDLLDLGRLLQQPLHSGCASIRPRTRPAAQR--.--------------------------rrsacq
T0NJP2_CAMFR/29-186                 ...........................PAWVQGQQLSQQLCTLAWSAHLPMGHVDLPRE..EGEDETT.NGVP.HIQCGDGCDPQGLRDNSQ...........SCLQRIHQGLVFYEKLLG.SD.IFTGEASLFPHGPVGQLHASLLGLRQLLQPEGHHWETEQTPSPSPSQPWQR.LLLRLKILRSLQAFVAVAARVFAHGA......
IL23A_HUMAN/28-184                  ...........................PAWTQCQQLSQKLCTLAWSAHPLVGHMDL-RE..EGDEETT.NDVP.HIQCGDGCDPQGLRDNSQ...........FCLQRIHQGLIFYEKLLG.SD.IFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQR.LLLRFKILRSLQAFVAVAARVFAHGA......
#=GR IL23A_HUMAN/28-184       SS    ...........................--HHHHHHHHHHHHHHHHHSSTSSSTTTC-E-..TTHHHHH.CCS-.---CCCS-SHHHHHHHSH...........HHHHHHHHHHHHHHHHHT.SH.HHHSSS---TTSHHHHHHHHHHHHHHHHSTTTTTTST----TT--SSHHHH.HHHHHHHHHHHHHHHHHHHHHHHHHH......
W5PHK6_SHEEP/28-185                 ...........................PAWARGQQLSQQLCMLAWSAHLPMGHVDLPRE..EGGDETT.DDVP.RIQCEDGCDPQGLRDNSQ...........SCLQRIHRGLVFYEKLLG.SD.IFTGEPSLFPDGPVDQLHASILGLRELLQPKGHHWEAEQTPSPIPSQPWQR.LLLRLKILRSLQAFVAVAARVFAHGA......
F1MSN4_BOVIN/35-192                 ...........................PAWTRGQQLSQQLCMLAWSAHLPMGHVDLPRE..EGGDKTT.DDVP.RIQCEDGCDPQGLRDNSQ...........SCLQRIHRGLVFYEKLLG.SD.IFTGEPSLLPNGPVDQLHASILGLRELLQPKGHHWETEQTPSPIPSQPWQR.LLLRLKILRSLQAFVAVAARVFAHGA......
G3QH19_GORGO/28-184                 ...........................PAWAQCQQLSQKLCTLAWSAHPLVGHMEL-RE..EEDEETT.NDVP.RIQCGDGCDPQGLRDNSQ...........FCLQRIHQGLIFYEKLLG.SD.IFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQR.LLLRFKILRSLQAFVAVAARVFAHGA......
G5BB75_HETGA/28-184                 ..........................a-AWAQCQQLSQKLCTLAWSAHPLVGHVDPPRE..EGDEETA.DDVP.HIQCGDGCDPQGLKDNSQ...........FCLQRIYQGLIFYQKLLG.SD.IFTGEPSLLPDGPVGQLHASLLGLSQLLQPEDHQQE-TQTPSLSPSQPWQR.LLLRIKILRSLQAFVAVAARVFAHGA......
A0A151ND31_ALLMI/1-123              .......................melq--------------------------------..-EQEPGQ.DPTP.RIRCTDGCDPGALSTDSS...........HCLGRIRQGLQHYRALLG.SE.LFAGRSH------APDLEDALAQLSHLLQHLGKGDVELWRPTLEPSLLWAR.SIIQHRTLRQLQAFSAVVARVFAHGA......
F7HQI5_MACMU/28-184                 ...........................PAWAQCQQLSQKLCTLAWSAHPLVGHMDL-RE..EGDEETT.NDVP.HIQCGDGCDPQGLRDNSQ...........FCLQRIRQGLIFYEKLLG.SD.IFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSPSPSQPWQR.LLLRFKILRSLQAFVAVAARVFAHGA......
A0A2K5LDE9_CERAT/28-184             ...........................PAWAQCQQLSQKLCTLAWSAHPLVGHMDL-RE..EGDEETT.NDVP.HIQCGDGCDPQGLRDNSQ...........FCLQRIRQGLIFYEKLLG.SD.IFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSPSPSQPWQR.LLLRFKILRSLQAFVAVAARVFAHGA......
A0A1A6GZN1_NEOLE/28-87              ...........................PDWAQCQQLSRSLCTLAWSAHPPVGHTDILRE..--DEETS.NDVP.HIQCGDGCDPQGLKDDSQ...........------------------.--.---------------------------------------------------.--------------------------p.....
A0A096NH07_PAPAN/28-184             ...........................PAWAQCQQLSQKLCTLAWSAHPLVGHMDL-RE..EGDEETT.NDVP.HIQCGDGCDPQGLRDNSQ...........FCLQRIRQGLIFYEKLLG.SD.IFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSPSPSQPWQR.LLLRFKILRSLQAFVAVAARVFAHGA......
F7H1B4_CALJA/28-184                 ...........................PAWTQCQQLSQKLCMLAWSAHPLVGHMHL-RE..EGDEETT.NDVP.HIQCGDGCDPQGLRDNSQ...........FCLQRIHQGLIFYEKLLG.SD.IFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSPGPSQPWQR.LLLRFKILRSLQAFVAVAARVFAHGA......
A0A1U7QS90_MESAU/28-185             ...........................PDWAQCQQLSRNLCTLAWDAQPPVGHMDILRE..EGNEETR.NDVP.HIQCGDGCDPQGLKDNSQ...........FCLQRIRQGLVFYKQLLD.SD.IFTGEPALLPDGPMGQLHTSLLGLSQLLQPEDHQWESQQMPSLSPSQQWQR.PLLRSKILRSLQAFVAIAARVFAHGA......
G3VET0_SARHA/31-186                 ...........................VAWDLCQELSQNVTALAWGIHPEMGNLELPRE..EGTGEAV.DDVP.HIQCGDGCDHQSLNDNSQ...........LCLQQIHRGLIFYGHLLN.SD.IFKGEPSLLQDGPVGQLHSSLLGLSQLLQPKDHSWKKQQVPS--PSEPWQR.LLLRPKILQRLRAFAAIAARVFTHGA......
G1S6V2_NOMLE/28-184                 ...........................PAWAQCQQLSQKLCTLAWSAHPLVGHMDL-RE..EGDEETT.NDVP.HIQCGDGCDPQGLRDNSQ...........FCLQRIHQGLIFYEKLLG.SD.IFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQR.LLLRFKILRSLQAFVAVAARVFAHGA......
#=GC SS_cons                        ...........................--HHHHHHHHHHHHHHHHHSSTSSSTTTC-E-..TTHHHHH.CCS-.---CCCS-SHHHHHHHSH...........HHHHHHHHHHHHHHHHHT.SH.HHHSSS---TTSHHHHHHHHHHHHHHHHSTTTTTTST----TT--SSHHHH.HHHHHHHHHHHHHHHHHHHHHHHHHH......
#=GC seq_cons                       ...........................PAWuQCQQLSQ+LCTLAWSAHP.sGHhDL.RE..EGDEETT.sDVP.HIQCGDGCDPQGL+DNSQ...........FCLQRI+QGLlFYEKLLG.SD.IFTGEPSLLPDuPVGQLHASLLGLSQLLQPEGHHWETpQhPS.SPSQPWQR.LLLRhKILRSLQAFVAVAARVFAHGA......
//
DBGET integrated database retrieval system