GenomeNet

Database: Pfam
Entry: IMUP
LinkDB: IMUP
Original site: IMUP 
#=GF ID   IMUP
#=GF AC   PF15761.6
#=GF DE   Immortalisation up-regulated protein
#=GF AU   Eberhardt R;0000-0001-6152-1369
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Jackhmmer:Q9GZP8
#=GF GA   27.00 27.00;
#=GF TC   30.30 29.70;
#=GF NC   26.80 26.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11606055
#=GF RT   Identification of hepatocyte growth factor activator inhibitor
#=GF RT   type 2 (HAI-2)-related small peptide (H2RSP): its nuclear
#=GF RT   localization and generation of chimeric mRNA transcribed from
#=GF RT   both HAI-2 and H2RSP genes.
#=GF RA   Itoh H, Kataoka H, Yamauchi M, Naganuma S, Akiyama Y, Nuki Y,
#=GF RA   Shimomura T, Miyazawa K, Kitamura N, Koono M;
#=GF RL   Biochem Biophys Res Commun. 2001;288:390-399.
#=GF RN   [2]
#=GF RM   12604353
#=GF RT   Characterization of transcripts generated from mouse hepatocyte
#=GF RT   growth factor activator inhibitor type 2 (HAI-2) and
#=GF RT   HAI-2-related small peptide (H2RSP) genes: chimeric mRNA
#=GF RT   transcribed from both HAI-2 and H2RSP genes is detected in human
#=GF RT   but not in mouse.
#=GF RA   Naganuma S, Itoh H, Uchiyama S, Tanaka H, Nagaike K, Miyata S,
#=GF RA   Uchinokura S, Nuki Y, Akiyama Y, Chijiiwa K, Kataoka H;
#=GF RL   Biochem Biophys Res Commun. 2003;302:345-353.
#=GF RN   [3]
#=GF RM   18507030
#=GF RT   Imup-1 and imup-2 overexpression in endometrial carcinoma in
#=GF RT   Korean and Japanese populations.
#=GF RA   Kim SJ, An HJ, Kim HJ, Jungs HM, Lee S, Ko JJ, Kim IH, Sakuragi
#=GF RA   N, Kim JK;
#=GF RL   Anticancer Res. 2008;28:865-871.
#=GF RN   [4]
#=GF RM   20432246
#=GF RT   Increased immortalization-upregulated protein 2 (IMUP-2) by
#=GF RT   hypoxia induces apoptosis of the trophoblast and pre-eclampsia.
#=GF RA   Jeon SY, Lee HJ, Park JM, Jung HM, Yoo JK, Lee HJ, Lee JS, Cha
#=GF RA   DH, Kim JK, Kim GJ;
#=GF RL   J Cell Biochem. 2010;110:522-530.
#=GF RN   [5]
#=GF RM   22886722
#=GF RT   Hypoxia-induced downregulation of XIAP in trophoblasts mediates
#=GF RT   apoptosis via interaction with IMUP-2: Implications for
#=GF RT   placental development during pre-eclampsia.
#=GF RA   Jeon SY, Lee HJ, Na KH, Cha DH, Kim JK, Park JW, Yoon TK, Kim
#=GF RA   GJ;
#=GF RL   J Cell Biochem. 2012; [Epub ahead of print]
#=GF DR   INTERPRO; IPR026621;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family of proteins is found in eukaryotes. Proteins in this
#=GF CC   family are approximately 100 amino acids in length. There are
#=GF CC   two conserved sequence motifs: GDPK and KKPK.
#=GF SQ   58
#=GS K7EQZ3_HUMAN/72-151      AC K7EQZ3.1
#=GS A0A2K6JZI3_RHIBE/1-101   AC A0A2K6JZI3.1
#=GS W5Q2Y0_SHEEP/1-109       AC W5Q2Y0.1
#=GS A0A383ZYT4_BALAS/1-113   AC A0A383ZYT4.1
#=GS A0A1S3G130_DIPOR/1-100   AC A0A1S3G130.1
#=GS A0A2K5J370_COLAP/1-101   AC A0A2K5J370.1
#=GS A0A1L8F3U4_XENLA/22-135  AC A0A1L8F3U4.1
#=GS A0A3Q7SS89_VULVU/1-103   AC A0A3Q7SS89.1
#=GS A0A2K5RHX8_CEBCA/1-101   AC A0A2K5RHX8.1
#=GS A0A1D5RHX7_MACMU/1-86    AC A0A1D5RHX7.1
#=GS A0A2Y9FSY9_PHYMC/1-99    AC A0A2Y9FSY9.1
#=GS A0A3Q7TXI0_VULVU/46-145  AC A0A3Q7TXI0.1
#=GS G1LVB3_AILME/1-102       AC G1LVB3.1
#=GS A0A0D9QVS3_CHLSB/1-102   AC A0A0D9QVS3.1
#=GS G3S7U1_GORGO/1-105       AC G3S7U1.1
#=GS F6S0T9_CALJA/1-102       AC F6S0T9.1
#=GS A0A340YIB3_LIPVE/47-122  AC A0A340YIB3.1
#=GS A0A2K5XBH8_MANLE/1-102   AC A0A2K5XBH8.1
#=GS A0A2U3ZBR4_ODORO/1-81    AC A0A2U3ZBR4.1
#=GS A0A2K6V7B5_SAIBB/1-100   AC A0A2K6V7B5.1
#=GS A0A3Q1MRZ8_BOVIN/1-82    AC A0A3Q1MRZ8.1
#=GS A0A452RFN0_URSAM/1-102   AC A0A452RFN0.1
#=GS H0V8D3_CAVPO/1-99        AC H0V8D3.2
#=GS A0A2K5MMZ5_CERAT/1-102   AC A0A2K5MMZ5.1
#=GS D3ZE02_RAT/1-104         AC D3ZE02.2
#=GS G1S4V3_NOMLE/1-101       AC G1S4V3.1
#=GS A0A2Y9LHC2_ENHLU/1-105   AC A0A2Y9LHC2.1
#=GS A0A3Q7UPY5_URSAR/1-102   AC A0A3Q7UPY5.1
#=GS A0A096N5U1_PAPAN/1-102   AC A0A096N5U1.1
#=GS W5P6B0_SHEEP/1-102       AC W5P6B0.1
#=GS F6ZWC7_HORSE/1-101       AC F6ZWC7.2
#=GS H2NYN3_PONAB/1-101       AC H2NYN3.1
#=GS A0A1U8CMS4_MESAU/1-99    AC A0A1U8CMS4.1
#=GS A0A2R8NER9_CALJA/34-115  AC A0A2R8NER9.1
#=GS A0A2K5W1I2_MACFA/1-102   AC A0A2K5W1I2.1
#=GS A0A1U7R2T0_MESAU/1-100   AC A0A1U7R2T0.1
#=GS A0A2R9A4E6_PANPA/1-100   AC A0A2R9A4E6.1
#=GS A0A2Y9P330_DELLE/1-148   AC A0A2Y9P330.1
#=GS A0A340YIB3_LIPVE/1-54    AC A0A340YIB3.1
#=GS A0A1S3WQI8_ERIEU/1-80    AC A0A1S3WQI8.1
#=GS A0A2I2V139_FELCA/1-107   AC A0A2I2V139.2
#=GS G5AMC1_HETGA/39-144      AC G5AMC1.1
#=GS A0A091DEV3_FUKDA/1-44    AC A0A091DEV3.1
#=GS A0A2Y9G1A0_TRIMA/1-104   AC A0A2Y9G1A0.1
#=GS Q9D809_MOUSE/1-114       AC Q9D809.1
#=GS A0A2K6QNT4_RHIRO/1-101   AC A0A2K6QNT4.1
#=GS A0A2K5E6Y1_AOTNA/1-101   AC A0A2K5E6Y1.1
#=GS IMUP_HUMAN/1-106         AC Q9GZP8.1
#=GS A0A3Q1MKU7_BOVIN/1-102   AC A0A3Q1MKU7.1
#=GS A0A2K6BGI0_MACNE/1-102   AC A0A2K6BGI0.1
#=GS A0A2K6EZC3_PROCO/1-104   AC A0A2K6EZC3.1
#=GS A0A091DEV3_FUKDA/37-79   AC A0A091DEV3.1
#=GS F1RKJ3_PIG/1-103         AC F1RKJ3.2
#=GS M3Z2C0_MUSPF/1-104       AC M3Z2C0.1
#=GS A0A2R8MJK7_CALJA/7-105   AC A0A2R8MJK7.1
#=GS A0A287CTX8_ICTTR/1-117   AC A0A287CTX8.1
#=GS A0A3Q7V5L7_URSAR/1-101   AC A0A3Q7V5L7.1
#=GS H2QG78_PANTR/1-106       AC H2QG78.1
K7EQZ3_HUMAN/72-151                 ...lgs------KALEPTSQK..PGvGAGHG...GDPKL.SPHKVQGRSEAGAGPG................PKASNfrGL...................GKGRRLTAAPPSSKDTTALPTPAA...---..-----------------.----.----..------apairt..................................
A0A2K6JZI3_RHIBE/1-101              ......MEFDLGAALEPTSQK..PGvGAGHG...GDPKL.NPHKVQGQSEAGAGPG................PKQGH..--...................HSSSDSSSS---SSDSDTDVKPHT...TGS..KQHESTPGKAKKPKVKK.KKEK.---G..KKEA--pq......................................
W5Q2Y0_SHEEP/1-109                  ......MEFDLSAAVESTSKK..PQ.GAGKV...GDPKH.SPTKVQSGSANNLKHH................HGHGH..GQ...................GSASDSSSS---SSDSENEAKP--...-SS..EPHRSASGQVKKPKVKK.EKKE.EEEG..E-----egeekekkkekr............................
A0A383ZYT4_BALAS/1-113              ......MEVDLSAALKSTSKK..PQ.GAGQV...GDPKH.APAKIQG--ADNLKHH................HGHGH..GH...................EHGTSSDSS-CSSSDSENEAKPGA...AGS..EQHKSAPGKVKKPKVKK.EKKK.EEKKegKKK---egkkeeash...............................
A0A1S3G130_DIPOR/1-100              ......MEFDLSAALGSTSNK..PA.GAGQV...VDPKS.CPHKAQGGPKAGAAQH................PKQRH..--...................GSSSDSSSSSSSSSEAESEGKA--...AGC..EQRKPCPDKAKKPKKKE.KKGK.KEK-..------aph.....................................
A0A2K5J370_COLAP/1-101              ......MEFDLRAALEPTSQK..PGvGAGHG...GDPKL.SPHKAQGRSEAGAGPG................PKQGH..--...................HSSSDSSSS---SSDSDTDVKPHT...TDS..KQHESTPGKAKKPKVKK.KK--.-EKG..KKEAPH........................................
A0A1L8F3U4_XENLA/22-135             ......MDFNLAAAVDPKKCQvtPK.QPCHGdvkHDHKH.GPHGHGGHGSKHCKGH................KG-DH..G-...................HSSSDSSSSS-SSSGSECEGKPHG...EGHthKKKEKKQHKEKKPKDKK.EKKE.KKE-..KKEH--kdkkh...................................
A0A3Q7SS89_VULVU/1-103              ......MEFDLTAALD--SKK..PH.GTGQE...GDHKH.SAPKAQGAS----ADK................PR-GH..GH...................RSSSDSSSSSGSSCCSDHEGKPRA...AAP..GQHGRSPGQAEKRKVKK.KKEK.KEKGkaKKEAPH........................................
A0A2K5RHX8_CEBCA/1-101              ......MEFNLGAALEPTSQK..PGvGVGHG...GDPKL.SPHKVQGRSEAGGDPS................SKQGR..--...................HSSSDSSSS---SSDSDTDVKPQA...AGC..KQQENTLGKTKKPKVKK.EEKG.KK--..-KEAPH........................................
A0A1D5RHX7_MACMU/1-86               ......MEFDLGAALEPTSQK..PGvGAGHG...GDPKL.SPHKVQGRSEAGAGPG................PE---..--...................------------------------...---..-----------------.----.----..------gpalgfqlrglgkghrltaappsskdttalptpaaapatr
A0A2Y9FSY9_PHYMC/1-99               ......MEVDLSAALESTSKK..PQ.GAGQV...GDPKH.APAKVQG--ADNLKHG................HG--H..EH...................GSSSDSSSS---SSDSENEAKPGA...AGS..EQHKSAPGKVKKPKVKK.EKKK.G-K-..KKEASH........................................
A0A3Q7TXI0_VULVU/46-145             .....l----LSTALD--SKK..PH.GTGQE...GDHKH.SAPKAQGAS----ADK................PR-GH..GH...................RSSSDSSSSSGSSCCSDHEGKPRA...AAP..GQHGRSPGQAEKRKVKK.KKEK.KEKGkaKKEAPH........................................
G1LVB3_AILME/1-102                  ......TEFDLAAALD--SKK..PQ.GTGQV...GDHKH.SPSKVQGASEAGAADK................MRQGR..GH...................RSSSDSSSSS--SSDSDVEAKPHA...AAS..EGHKSAPGKVKKPKVKK.EKKG.KAK-..-KEA--pr......................................
A0A0D9QVS3_CHLSB/1-102              ......MEFDLGAALEPTSQK..PGvGAGHG...GDPKL.SPHKVQGRSEAGAGPG................PEQGH..--...................HSSSDSSSS---SSDSDTDVKPHT...AGS..KQHESTPGKAKKPKVKK.KKKE.KGKE..A-----aph.....................................
G3S7U1_GORGO/1-105                  ......MEFDLGAALEPTSQK..PGvGAGHG...GDPKL.SPHKVQGRSEAGAGPG................PKQGH..--...................HSSSDSSSS---SSDSDTDVKSHA...AGS..KQHESIPGKAKKPKVKK.EKGK.KEKG.kKKEAP-h.......................................
F6S0T9_CALJA/1-102                  ......MEFDLGAALEPTSQK..PGlGLGHG...GDPKL.SPHKVQGQSEAGGGPS................SKQGR..--...................HSSSDSSSS---SSDSDTNVKSQA...AGS..KKQESTPGKAKKPKVKK.KK-E.KGK-..KKEAPH........................................
A0A340YIB3_LIPVE/47-122             ghghgg---------------..--.-----...-----.----------RGHGGH................GRGGH..GH...................GHSSDSSGS---ASDSENEAKPYAaaaAGS..EKHKSALGKVKKPKVKK.EKKK.EEEE..-KE---xge.....................................
A0A2K5XBH8_MANLE/1-102              ......MEFDLGAALEPASQK..PGvGAGHE...GDPKL.SPHKVQGRSEAGAGPG................PEQGH..--...................HSSSDSSSS---SSDSDTDVKPHT...AGS..KQHESTPGKAKKPKVKK.KKKE.KGK-..-KEAPH........................................
A0A2U3ZBR4_ODORO/1-81               ......MELDLAAALD--SKE..PQ.GTGQV...GDHKH.SPPKVQGASEAGAADK................PR-GG..GH...................RSSSDSSSDS--SSDSDMEAKVRG...S--..-----------------.----.----..------pqagapgdgtv.............................
A0A2K6V7B5_SAIBB/1-100              ......MEFDLGAALEPTSQK..PGvGVGHG...GDPKL.NPHKVQGPSEAGGDLS................SKQGR..--...................HSSSDSSSS---SSNSDTDVKPQA...AGS..KRQENMPGKAKKLKVKK.KKGK.KEG-..------aph.....................................
A0A3Q1MRZ8_BOVIN/1-82               ......MEFDLSAAVESTSKK..PQ.GAGKV...GDPKH.SSPKVQGGSADNLKHH................HGHGH..GQ...................GSASDSSSS---SSDSENEAKVR-...---..-----------------.----.----..------gfplcsgcpapq............................
A0A452RFN0_URSAM/1-102              ......MEFDLAAALD--SKK..PQ.GTGQV...GDHKH.SPSKVQGASEAGAADK................MRQGR..GH...................RSSSDSSSS---SSDSDVEAKPHA...AAS..EGHKSAPGKVKKPKVKK.K-EK.KGKA..KKEAP-r.......................................
H0V8D3_CAVPO/1-99                   ......MDFSLAAALDSNSKE..TE.GTCKL...GDPKH.GSPKAQG--RPGAGQE................PRHGH..--...................GSSSDSSSSS--SSDSDSEGKS--...---..QQHKDTADKTKKPKMKK.DKKD.KDKKkdKKE---tar.....................................
A0A2K5MMZ5_CERAT/1-102              ......MEFDLGAALEPTSQK..PGvGAGHG...GDPKL.SPHKVQGRSEAGAGPG................PEQGH..--...................HSSSDSSSS---SSDSDTDVKPHT...AGS..KQHESTPGKAKKPKVKK.KKKE.KGK-..-KEAPH........................................
D3ZE02_RAT/1-104                    ......MEFDLAAALGPGSKK..PE.GAGQV...GDPKH.CPLKAPGRPEAGAAHK................PRHGP..GG...................SSDSSSSSSSSSSSDSEAEGKAHA...AGC..KKHERSSDKAKKPKVKK.ERKK.KEK-..------tph.....................................
G1S4V3_NOMLE/1-101                  ......MEFDLGAALEPTSQK..PGvGAGHG...GDPKL.SPHKVQGRSEAGAGPG................PKQGH..--...................HSSSDSSSS---SSDSDTDVKPHA...AGS..KQHESTPGKAKKPKVKK.KKGK.K---..KKEASH........................................
A0A2Y9LHC2_ENHLU/1-105              ......MEFDLAAALD--SKK..PQ.GTGQG...GDHKH.GPHKVQGASETGAADK................PR-GH..GH...................RSSSDSSSSSGSSSDSDMEGKPHA...AAS..QGHESTLAKVKKPKVKK.KKEK.KGKA..KKETSH........................................
A0A3Q7UPY5_URSAR/1-102              ......MEFDLAAALD--SKK..PQ.GTGQV...GDHKH.SPSKVQGASEAGAADK................MRQGR..GH...................RSSSDSSSS---SSDSDVEAKPHA...AAS..EGHKSAPGKVKKPKVKK.K-EK.KGKA..KKEAP-r.......................................
A0A096N5U1_PAPAN/1-102              ......MEFDLGAALEPTSQE..PGvEAGHG...GDPKL.SPHKLQGRSEAGAGPG................PEQGH..--...................HSSSDSSSS---SSDSDTDVKPHT...AGS..KQHESTPGKAKKPKVKK.KKKE.KGK-..-KEAPH........................................
W5P6B0_SHEEP/1-102                  ......MEFDLSAAVEPTSKK..PQ.GAGKV...GDPKH.SPPKVQGGSADHLKHH................HGHGH..GQ...................GSASDSSSS---SSDSENEAKP--...-SS..EPHKSASGKVKKPKVKK.EKKK.KEEG..KKKASH........................................
F6ZWC7_HORSE/1-101                  ......MEFDLAAAVEPSSEK.hPE.-AGQV...GDPKQ.SPPKIQGPSAAGAAGS................PRVSH..--...................----RTTSSSSNSSDSDPEAKVRA...APP..QRHEGTAGKVKKPKVKK.KKKE.KGK-..KKEAPH........................................
H2NYN3_PONAB/1-101                  ......MEFDLGAALEPTSQK..PGvGAGHG...GDPKL.SPHKVQGRPEAGAGPG................PKQGH..--...................HSSSDSSSS---SSDSDTDVKPHA...AGS..KQHESTPGKAKKPKVKK.KK--.-EKG..KKEAPH........................................
A0A1U8CMS4_MESAU/1-99               ......MEFDLAAAVGHGSKK..PE.-GGQA...GHPKH.CPLKAPGRPEAGAAHK................PKHGP..--...................GSSSDSSSSS--SSDSEAEGK-HA...AGC..KKHEGSSDKAKKPKVKK.EKKK.KEKK..------pph.....................................
A0A2R8NER9_CALJA/34-115             ...tsl----LSAALEPTSQK..PGlGLGHG...GDPKL.SPHKVQGQSEAGGGPS................SKVS-..--...................------------------------...---..-----------------.----.----..------llttsfrgvgrgpcltatppsskaatalrtpaaap.....
A0A2K5W1I2_MACFA/1-102              ......MEFDLGAALEPTSQK..PGvGAGHG...GDPKL.SPHKVQGRSEAGAGPG................PEQGH..--...................HSSSDSSSS---SSDSDMDVKPHT...AGS..KQHESTPGKAKKPKVKK.KKKE.KGK-..-KEAPH........................................
A0A1U7R2T0_MESAU/1-100              ......MEFDLAAAVGHGSKK..PE.-GGQA...GHPKH.CPLKAPGRPEAGAAHK................PKHGP..--...................GSSSDSSSSS--SSDSEAEGKKHA...AGC..KKHEGSSDKAKKPKVKK.EKKK.KEKK..------pph.....................................
A0A2R9A4E6_PANPA/1-100              ......MEFDLGAALEPTSQK..PGvGAGHR...GDPKL.SPHKVQGRSEAGAGPG................PKQGH..--...................QSSSDSSSS---SSDSDTDVKSHA...AGS..KQHESIPGKAKKPKVKK.KEKG.KK--..--EA--ph......................................
A0A2Y9P330_DELLE/1-148              ....me---HLSAALESTSKK..PH.GAGQV...GDPKH.APDKVEGADNPKHGHGhghgpgpgpghghghvHGHGH..GHgpgpghghghgpgpghghgHGHGSSSGSGSGSSDSENEAKPSA...AVS..ELYKSAPGKVKKPKVKK.EKKK.EEKKegKKK---egkeash.................................
A0A340YIB3_LIPVE/1-54               ......MDVDLSAALESTS-K..PQ.GADLV...GDPKH.APDKVEGADTER--HG................HGHGH..GG...................H-----------------------...---..-----------------.----.----..------ghggrg..................................
A0A1S3WQI8_ERIEU/1-80               .....m-----------ASKK..PH.GAGHL...GDSKHhDPSKVHP----GAADK................PK-GH..GH...................GSSSSSSS----SSDSDSGGK---...---..--HGSTPGKTKTPKMKK.PKDG.KKSE..HK----ph......................................
A0A2I2V139_FELCA/1-107              ......MEFDLAAALDSTSKK..PQ.GTAQV...GDHKH.STPKVQGPSEAGAADK................PKHGH..GH...................RSSSDSSSSSSSSGDSDVEAKPHA...AAS..DKHKSTAGKVKKPKVKK.QKK-.KEKA..KKEAPH........................................
G5AMC1_HETGA/39-144                 ......MDFSLAAALDSKSKK..PE.GACKL...GDPKH.GPPKAHG--EPGAAQK................PRPCH..--...................GSSSDSSSSSSSSSDSDSEGKPHA...AGS..QQHKGTADKLKKPKMKK.DKKG.KDKKkgKKEAAH........................................
A0A091DEV3_FUKDA/1-44               ......MDFSLAAALDSNSKK..LE.GACKL...GDPKH.VPPKAHGGP--GAPQK................P----..--...................------------------------...---..-----------------.----.----..------rp......................................
A0A2Y9G1A0_TRIMA/1-104              ......MEFDLSAALESTSKK..PD.GAGQG...EKPKH.SPHNVHGPSMAGAAAN................PRHDH..--...................GSSSDSSSSSSSSSDSDTEGKLHA...TGS..HLQASAPGQAKKPKVKK.KKEE.KGKK..AE----kg......................................
Q9D809_MOUSE/1-114                  ......MEFDLAAALGPGSKK..PE.GAGHV...GDPKH.CPLKAPGGPEAGAAHK................PRRVS..--...................GSSSDSSSSS-SSSDSEAEGKEYA...AGC..KKHERSSDKAKKPKVKK.EKME.KKEKkeKK----ekekkekkaph.............................
A0A2K6QNT4_RHIRO/1-101              ......MEFDLGAALEPTSQK..PGvGAGHG...GDPKL.NPHKVQGQSEAGAGPG................PKQGH..--...................HSSSDSSSS---SSDSDTDVKPHT...TGS..KQHESTPGKAKKPKVKK.KK--.-EKG..KKEAPH........................................
A0A2K5E6Y1_AOTNA/1-101              ......MEFDLGAALEPTSQK..PGvGVGHG...GDHKL.SPHKVQGRSEAEGDLS................SKQGR..--...................HSSSDSSSS---SSDSDTDVKPQA...AGS..KQQESTPGKAKKPKVKK.KEKG.K---..KKEAPH........................................
IMUP_HUMAN/1-106                    ......MEFDLGAALEPTSQK..PGvGAGHG...GDPKL.SPHKVQGRSEAGAGPG................PKQGH..--...................HSSSDSSSS---SSDSDTDVKSHA...AGS..KQHESIPGKAKKPKVKKkEKGK.KEKG.kKKEAPH........................................
A0A3Q1MKU7_BOVIN/1-102              ......MEFDLSAAVESTSKK..PQ.GAGKV...GDPKH.SSPKVQGGSADNLKHH................HGHGH..GQ...................GSASDSSSS---SSDSENEAKS--...-GS..EQHKSASGKVKKPKVKK.EKKK.KEEG..KKKASH........................................
A0A2K6BGI0_MACNE/1-102              ......MEFDLGAALEPTSQK..PGaGAGHG...GDPKL.SPHKVQGRSEAGAGPG................PGQGH..--...................HSSSDSSSS---SSDSDMDVKPHT...AGS..KQHESTPGKAKKPKVKK.KKKE.KGK-..-KEAPH........................................
A0A2K6EZC3_PROCO/1-104              ......MDLDLAAALGSTSKK..PG.GAGQV...GDLKH.GPPKVPG--QAGAAQN................PRHGH..GS...................SSDSSSSSSS-SDSDSDREGKPHA...AGA..KQHGSSPGKA-KPKGKK.NKDKgKEKG..KK-A--sr......................................
A0A091DEV3_FUKDA/37-79              .gapqk---------------..--.-----...-----.----------------................-----..--...................-------------------PRPHA...AGS..QKHKGTADKPKKPKMKK.DKDK.RKK-..GKEAAH........................................
F1RKJ3_PIG/1-103                    ......MEFDLSAAVESPSKK..PH.----V...GDPKH.SPNKVQGGSADNLKHH................HGHGH..GR...................SSDSSSSSSS-SSSDSENEAKPGA...AGS..QQHKSASDKVKKPKVKK.EKKK.KEDE..KKKPSH........................................
M3Z2C0_MUSPF/1-104                  ......MEFDLAAALD--SKK..PQ.GTGQG...GDHKH.GPHKVQGASETGAADK................PR-GH..GH...................RSSSDSSSSSGSSSDSDMEGKPHA...AAS..QGHESTPAKVKKPKVKK.KKQK.KGK-..AKETSH........................................
A0A2R8MJK7_CALJA/7-105              ...lef----LPSALEPTSQK..PGlGLGHG...GDPKL.SPHKVQGQSEAGGGPS................SK-SH..--...................-FQPRTISSL-PI--LPSAPQSQA...AGS..KKQESTPGKAKKPKVKK.KK-E.KGK-..KKEAPH........................................
A0A287CTX8_ICTTR/1-117              ......MEFNLATALDSNSKK..PA.GTGQV...RDPWH.GPSKAQCPPEAGAPRK................PRHGN..GS...................SSDSSSSSSSSSSSDSDAEGKCHA...AGA..KQHEATPGQAKKLKVKK.KKEE.KKDK.kEK----kekkekgnksph............................
A0A3Q7V5L7_URSAR/1-101              ......MEFDLAAALD--SKK..PQ.GTGQV...GDHKH.SPSKVQGASEAGAADK................MR-GR..GH...................RSSSDSSSS---SSDSDVEAKPHA...AAS..EGHKSAPGKVKKPKVKK.K-EK.KGKA..KKEAP-r.......................................
H2QG78_PANTR/1-106                  ......MEFDLGAALEPTSQK..PGvGAGHR...GDPKL.SPHKVQGRSEAGAGPG................PKQGH..--...................QSSSDSSSS---SSDSDTDVKSHA...AGS..KQHESIPGKAKKPKVKKkEKGK.KEKG.kKKEAPH........................................
#=GC seq_cons                       ......MEFDLuAAL-soSpK..Pt.GuGps...GDPKh.SPpKVQGtSEAGAusp................P+pGH.......................pSSSDSSSS...SSDSDs-sKP+A...AGS..cpHcSssGKsKKPKVKK.cKcc.KtK...tKcs..........................................
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