GenomeNet

Database: Pfam
Entry: IMUP
LinkDB: IMUP
Original site: IMUP 
#=GF ID   IMUP
#=GF AC   PF15761.5
#=GF DE   Immortalisation up-regulated protein
#=GF AU   Eberhardt R;0000-0001-6152-1369
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Jackhmmer:Q9GZP8
#=GF GA   27.00 27.00;
#=GF TC   27.40 27.40;
#=GF NC   26.90 26.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11606055
#=GF RT   Identification of hepatocyte growth factor activator inhibitor
#=GF RT   type 2 (HAI-2)-related small peptide (H2RSP): its nuclear
#=GF RT   localization and generation of chimeric mRNA transcribed from
#=GF RT   both HAI-2 and H2RSP genes.
#=GF RA   Itoh H, Kataoka H, Yamauchi M, Naganuma S, Akiyama Y, Nuki Y,
#=GF RA   Shimomura T, Miyazawa K, Kitamura N, Koono M;
#=GF RL   Biochem Biophys Res Commun. 2001;288:390-399.
#=GF RN   [2]
#=GF RM   12604353
#=GF RT   Characterization of transcripts generated from mouse hepatocyte
#=GF RT   growth factor activator inhibitor type 2 (HAI-2) and
#=GF RT   HAI-2-related small peptide (H2RSP) genes: chimeric mRNA
#=GF RT   transcribed from both HAI-2 and H2RSP genes is detected in human
#=GF RT   but not in mouse.
#=GF RA   Naganuma S, Itoh H, Uchiyama S, Tanaka H, Nagaike K, Miyata S,
#=GF RA   Uchinokura S, Nuki Y, Akiyama Y, Chijiiwa K, Kataoka H;
#=GF RL   Biochem Biophys Res Commun. 2003;302:345-353.
#=GF RN   [3]
#=GF RM   18507030
#=GF RT   Imup-1 and imup-2 overexpression in endometrial carcinoma in
#=GF RT   Korean and Japanese populations.
#=GF RA   Kim SJ, An HJ, Kim HJ, Jungs HM, Lee S, Ko JJ, Kim IH, Sakuragi
#=GF RA   N, Kim JK;
#=GF RL   Anticancer Res. 2008;28:865-871.
#=GF RN   [4]
#=GF RM   20432246
#=GF RT   Increased immortalization-upregulated protein 2 (IMUP-2) by
#=GF RT   hypoxia induces apoptosis of the trophoblast and pre-eclampsia.
#=GF RA   Jeon SY, Lee HJ, Park JM, Jung HM, Yoo JK, Lee HJ, Lee JS, Cha
#=GF RA   DH, Kim JK, Kim GJ;
#=GF RL   J Cell Biochem. 2010;110:522-530.
#=GF RN   [5]
#=GF RM   22886722
#=GF RT   Hypoxia-induced downregulation of XIAP in trophoblasts mediates
#=GF RT   apoptosis via interaction with IMUP-2: Implications for
#=GF RT   placental development during pre-eclampsia.
#=GF RA   Jeon SY, Lee HJ, Na KH, Cha DH, Kim JK, Park JW, Yoon TK, Kim
#=GF RA   GJ;
#=GF RL   J Cell Biochem. 2012; [Epub ahead of print]
#=GF DR   INTERPRO; IPR026621;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family of proteins is found in eukaryotes. Proteins in this
#=GF CC   family are approximately 100 amino acids in length. There are
#=GF CC   two conserved sequence motifs: GDPK and KKPK.
#=GF SQ   36
#=GS K7EQZ3_HUMAN/72-151      AC K7EQZ3.1
#=GS W5Q2Y0_SHEEP/1-109       AC W5Q2Y0.1
#=GS A0A1S3G130_DIPOR/1-100   AC A0A1S3G130.1
#=GS A0A2K5J370_COLAP/1-101   AC A0A2K5J370.1
#=GS A0A1L8F3U4_XENLA/22-135  AC A0A1L8F3U4.1
#=GS A0A1D5RHX7_MACMU/1-86    AC A0A1D5RHX7.1
#=GS G1LVB3_AILME/1-102       AC G1LVB3.1
#=GS A0A0D9QVS3_CHLSB/1-102   AC A0A0D9QVS3.1
#=GS F6ZWC7_HORSE/1-105       AC F6ZWC7.1
#=GS G3S7U1_GORGO/1-105       AC G3S7U1.1
#=GS F6S0T9_CALJA/1-102       AC F6S0T9.1
#=GS S2J8J2_MUCC1/182-279     AC S2J8J2.1
#=GS H0V8D3_CAVPO/1-99        AC H0V8D3.2
#=GS A0A2K5MMZ5_CERAT/1-102   AC A0A2K5MMZ5.1
#=GS G1S4V3_NOMLE/1-101       AC G1S4V3.1
#=GS D3ZE02_RAT/1-104         AC D3ZE02.2
#=GS A0A096N5U1_PAPAN/1-102   AC A0A096N5U1.1
#=GS W5P6B0_SHEEP/1-102       AC W5P6B0.1
#=GS S9YA56_CAMFR/34-83       AC S9YA56.1
#=GS F6RQM3_CALJA/1-85        AC F6RQM3.1
#=GS H2NYN3_PONAB/1-101       AC H2NYN3.1
#=GS A0A1U8CMS4_MESAU/1-99    AC A0A1U8CMS4.1
#=GS A0A1U7R2T0_MESAU/1-100   AC A0A1U7R2T0.1
#=GS A0A1S3WQI8_ERIEU/1-80    AC A0A1S3WQI8.1
#=GS A0A2I2V139_FELCA/1-94    AC A0A2I2V139.1
#=GS G5AMC1_HETGA/39-144      AC G5AMC1.1
#=GS A0A091DEV3_FUKDA/1-44    AC A0A091DEV3.1
#=GS Q9D809_MOUSE/1-114       AC Q9D809.1
#=GS E1BJC9_BOVIN/1-102       AC E1BJC9.2
#=GS IMUP_HUMAN/1-106         AC Q9GZP8.1
#=GS G7PXG1_MACFA/1-102       AC G7PXG1.1
#=GS A0A091DEV3_FUKDA/37-79   AC A0A091DEV3.1
#=GS F1RKJ3_PIG/1-103         AC F1RKJ3.2
#=GS M3Z2C0_MUSPF/1-104       AC M3Z2C0.1
#=GS A0A287CTX8_ICTTR/1-117   AC A0A287CTX8.1
#=GS H2QG78_PANTR/1-106       AC H2QG78.1
K7EQZ3_HUMAN/72-151                 ....................lgs------KALEPTSQK..PGvGAGHG...GDPKL.SPHKVQGRSEAGAGPGP.KASN-----------------------------..-----------------.--------..------frglgkgrrltaappsskdttalptpaaapairt......
W5Q2Y0_SHEEP/1-109                  .......................MEFDLSAAVESTSKK..PQ.GAGKV...GDPKH.SPTKVQSGSANNLKHHH.GHGHGQGSASDSSSS---SSDSENEAKP---SS..EPHRSASGQVKKPKVKK.EKKEEEEG..E-----egeekekkkekr............................
A0A1S3G130_DIPOR/1-100              .......................MEFDLSAALGSTSNK..PA.GAGQV...VDPKS.CPHKAQGGPKAGAAQHP.KQRH--GSSSDSSSSSSSSSEAESEGKA--AGC..EQRKPCPDKAKKPKKKE.KKGKKEK-..------aph.....................................
A0A2K5J370_COLAP/1-101              .......................MEFDLRAALEPTSQK..PGvGAGHG...GDPKL.SPHKAQGRSEAGAGPGP.KQGH--HSSSDSSSS---SSDSDTDVKPHTTDS..KQHESTPGKAKKPKVKK.KK---EKG..KKEAPH........................................
A0A1L8F3U4_XENLA/22-135             .......................MDFNLAAAVDPKKCQvtPK.QPCHGdvkHDHKH.GPHGHGGHGSKHCKGHKgDHGH---SSSDSSSSS-SSSGSECEGKPHGEGHthKKKEKKQHKEKKPKDKK.EKKEKKE-..KKEH--kdkkh...................................
A0A1D5RHX7_MACMU/1-86               .......................MEFDLGAALEPTSQK..PGvGAGHG...GDPKL.SPHKVQGRSEAGAGPGP.E--------------------------------..-----------------.--------..------gpalgfqlrglgkghrltaappsskdttalptpaaapatr
G1LVB3_AILME/1-102                  .......................TEFDLAAALD--SKK..PQ.GTGQV...GDHKH.SPSKVQGASEAGAADKM.RQGRGHRSSSDSSSSS--SSDSDVEAKPHAAAS..EGHKSAPGKVKKPKVKK.EKKGKAK-..-KEA--pr......................................
A0A0D9QVS3_CHLSB/1-102              .......................MEFDLGAALEPTSQK..PGvGAGHG...GDPKL.SPHKVQGRSEAGAGPGP.EQGH--HSSSDSSSS---SSDSDTDVKPHTAGS..KQHESTPGKAKKPKVKK.KKKEKGKE..A-----aph.....................................
F6ZWC7_HORSE/1-105                  .......................MEFDLAAAVEPSSEK.hPE.-AGQV...GDPKQ.SPPKIQGPSAAGAAGSP.RHGH--HGSSDSTSSSSNSSDSDPEAKVRAAPP..QRHEGTAGKVKKPKVKK.KKKEKGK-..KKEAPH........................................
G3S7U1_GORGO/1-105                  .......................MEFDLGAALEPTSQK..PGvGAGHG...GDPKL.SPHKVQGRSEAGAGPGP.KQGH--HSSSDSSSS---SSDSDTDVKSHAAGS..KQHESIPGKAKKPKVKK.EKGKKEKG.kKKEAP-h.......................................
F6S0T9_CALJA/1-102                  .......................MEFDLGAALEPTSQK..PGlGLGHG...GDPKL.SPHKVQGQSEAGGGPSS.KQGR--HSSSDSSSS---SSDSDTNVKSQAAGS..KKQESTPGKAKKPKVKK.KKE-KGK-..KKEAPH........................................
S2J8J2_MUCC1/182-279                tieeplsptspggrkksvsfsel---------------..--.-----...-----.DPVTVGGTPSMRQQMTN.GNGLNTTSSSSSSSSSDSSSDSDCDEKKS-KQQ..QQQPEQPALQKKPKVF-.--------..------tgrpikavss..............................
H0V8D3_CAVPO/1-99                   .......................MDFSLAAALDSNSKE..TE.GTCKL...GDPKH.GSPKAQG--RPGAGQEP.RHGH--GSSSDSSSSS--SSDSDSEGKS-----..QQHKDTADKTKKPKMKK.DKKDKDKKkdKKE---tar.....................................
A0A2K5MMZ5_CERAT/1-102              .......................MEFDLGAALEPTSQK..PGvGAGHG...GDPKL.SPHKVQGRSEAGAGPGP.EQGH--HSSSDSSSS---SSDSDTDVKPHTAGS..KQHESTPGKAKKPKVKK.KKKEKGK-..-KEAPH........................................
G1S4V3_NOMLE/1-101                  .......................MEFDLGAALEPTSQK..PGvGAGHG...GDPKL.SPHKVQGRSEAGAGPGP.KQGH--HSSSDSSSS---SSDSDTDVKPHAAGS..KQHESTPGKAKKPKVKK.KKGKK---..KKEASH........................................
D3ZE02_RAT/1-104                    .......................MEFDLAAALGPGSKK..PE.GAGQV...GDPKH.CPLKAPGRPEAGAAHKP.RHGPGGSSDSSSSSSSSSSSDSEAEGKAHAAGC..KKHERSSDKAKKPKVKK.ERKKKEK-..------tph.....................................
A0A096N5U1_PAPAN/1-102              .......................MEFDLGAALEPTSQE..PGvEAGHG...GDPKL.SPHKLQGRSEAGAGPGP.EQGH--HSSSDSSSS---SSDSDTDVKPHTAGS..KQHESTPGKAKKPKVKK.KKKEKGK-..-KEAPH........................................
W5P6B0_SHEEP/1-102                  .......................MEFDLSAAVEPTSKK..PQ.GAGKV...GDPKH.SPPKVQGGSADHLKHHH.GHGHGQGSASDSSSS---SSDSENEAKP---SS..EPHKSASGKVKKPKVKK.EKKKKEEG..KKKASH........................................
S9YA56_CAMFR/34-83                  .......................MEFDLSAAVESTSKK..PQ.AAGHM...GDAKH.SPHKVPGGSADHLK---.---------------------------------..-----------------.--------..------llrfqqqlq...............................
F6RQM3_CALJA/1-85                   .......................MEFDLGAALEPTSQK..PGlGLGHG...GDPKL.SPHKVQGQSEAGGGPSS.KVS------------------------------..-----------------.--------..------tsfggvgrgpcltatppsskaatalrtpaaapatrtr...
H2NYN3_PONAB/1-101                  .......................MEFDLGAALEPTSQK..PGvGAGHG...GDPKL.SPHKVQGRPEAGAGPGP.KQGH--HSSSDSSSS---SSDSDTDVKPHAAGS..KQHESTPGKAKKPKVKK.KK---EKG..KKEAPH........................................
A0A1U8CMS4_MESAU/1-99               .......................MEFDLAAAVGHGSKK..PE.-GGQA...GHPKH.CPLKAPGRPEAGAAHKP.KHGP--GSSSDSSSSS--SSDSEAEGK-HAAGC..KKHEGSSDKAKKPKVKK.EKKKKEKK..------pph.....................................
A0A1U7R2T0_MESAU/1-100              .......................MEFDLAAAVGHGSKK..PE.-GGQA...GHPKH.CPLKAPGRPEAGAAHKP.KHGP--GSSSDSSSSS--SSDSEAEGKKHAAGC..KKHEGSSDKAKKPKVKK.EKKKKEKK..------pph.....................................
A0A1S3WQI8_ERIEU/1-80               ......................m-----------ASKK..PH.GAGHL...GDSKHhDPSKVHP----GAADKP.K-GHGHGSSSSSSS----SSDSDSGGK------..--HGSTPGKTKTPKMKK.PKDGKKSE..HK----ph......................................
A0A2I2V139_FELCA/1-94               .......................MEFDLAAALDSTSKK..PQ.GTAQV...GDHKH.STPKVQGPSEAGAADKP.KHGHGHRSSSDSSSSSSSSGDSD----------..--HKSTAGKVKKPKVKK.QKKEKAK-..-KEAPH........................................
G5AMC1_HETGA/39-144                 .......................MDFSLAAALDSKSKK..PE.GACKL...GDPKH.GPPKAHG--EPGAAQKP.RPCH--GSSSDSSSSSSSSSDSDSEGKPHAAGS..QQHKGTADKLKKPKMKK.DKKGKDKKkgKKEAAH........................................
A0A091DEV3_FUKDA/1-44               .......................MDFSLAAALDSNSKK..LE.GACKL...GDPKH.VPPKAHGGP--GAPQKP.---------------------------------..-----------------.--------..------rp......................................
Q9D809_MOUSE/1-114                  .......................MEFDLAAALGPGSKK..PE.GAGHV...GDPKH.CPLKAPGGPEAGAAHKP.RRVS--GSSSDSSSSS-SSSDSEAEGKEYAAGC..KKHERSSDKAKKPKVKK.EKMEKKEK.kEKK---ekekkekkaph.............................
E1BJC9_BOVIN/1-102                  .......................MEFDLSAAVESTSKK..PQ.GAGKV...GDPKH.SSPKVQGGSADNLKHHH.GHGHGQGSASDSSSS---SSDSENEAKS---GS..EQHKSASGKVKKPKVKK.EKKKKEEG..KKKASH........................................
IMUP_HUMAN/1-106                    .......................MEFDLGAALEPTSQK..PGvGAGHG...GDPKL.SPHKVQGRSEAGAGPGP.KQGH--HSSSDSSSS---SSDSDTDVKSHAAGS..KQHESIPGKAKKPKVKKkEKGKKEKG.kKKEAP-h.......................................
G7PXG1_MACFA/1-102                  .......................MEFDLGAALEPTSQK..PGvGAGHG...GDPKL.SLHKVQGRSEAGAGPGP.EXXXXXXXXXX-----XXXXXXXXXXXPHTAGS..KQHESTPGKAKKPKVKK.KKKEKGK-..-KEAPH........................................
A0A091DEV3_FUKDA/37-79              ..................gapqk---------------..--.-----...-----.-----------------.-------------------------PRPHAAGS..QKHKGTADKPKKPKMKK.DKDKRKK-..GKEAAH........................................
F1RKJ3_PIG/1-103                    .......................MEFDLSAAVESPSKK..PH.----V...GDPKH.SPNKVQGGSADNLKHHH.GHGHGRSSDSSSSSSS-SSSDSENEAKPGAAGS..QQHKSASDKVKKPKVKK.EKKKKEDE..KKKPSH........................................
M3Z2C0_MUSPF/1-104                  .......................MEFDLAAALD--SKK..PQ.GTGQG...GDHKH.GPHKVQGASETGAADKP.R-GHGHRSSSDSSSSSGSSSDSDMEGKPHAAAS..QGHESTPAKVKKPKVKK.KKQKKGK-..AKETSH........................................
A0A287CTX8_ICTTR/1-117              .......................MEFNLATALDSNSKK..PA.GTGQV...RDPWH.GPSKAQCPPEAGAPRKP.RHGNGSSSDSSSSSSSSSSSDSDAEGKCHAAGA..KQHEATPGQAKKLKVKK.KKEEKKDK.kEK----kekkekgnksph............................
H2QG78_PANTR/1-106                  .......................MEFDLGAALEPTSQK..PGvGAGHR...GDPKL.SPHKVQGRSEAGAGPGP.KQGH--QSSSDSSSS---SSDSDTDVKSHAAGS..KQHESIPGKAKKPKVKKkEKGKKEKG.kKKEAP-h.......................................
#=GC seq_cons                       .......................MEFDLuAAL-ssSpK..Pt.GAG+s...GDPKh.SPpKVQGtSEAGAu.pP.+pG+..tSSSDSSSS...SSDS-s-sKspsAus..cpHcusssKsKKPKVKK.cKpcKtc....Kc...........................................
//
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