GenomeNet

Database: Pfam
Entry: Ig_5
LinkDB: Ig_5
Original site: Ig_5 
#=GF ID   Ig_5
#=GF AC   PF16681.5
#=GF DE   Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   pdb_1xiw-A
#=GF GA   27.30 27.30;
#=GF TC   27.30 27.30;
#=GF NC   27.20 27.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Immunoglobulin_superfamily
#=GF WK   Immunoglobulin_domain
#=GF RN   [1]
#=GF RM   15534202
#=GF RT   Crystal structure of a human CD3-epsilon/delta dimer in complex
#=GF RT   with a UCHT1 single-chain antibody fragment.
#=GF RA   Arnett KL, Harrison SC, Wiley DC;
#=GF RL   Proc Natl Acad Sci U S A. 2004;101:16268-16273.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Ig_5 is an immunoglobulin domain found on T-cell surface
#=GF CC   glycoprotein CD3 epsilon chain. It forms a first-order complex
#=GF CC   with T-cell surface glycoprotein CD3 delta chain as part of the
#=GF CC   T-cell receptor complex [1].
#=GF SQ   122
#=GS CD3E_RABIT/36-118         AC Q9TUF9.2
#=GS A0A093PFF9_PYGAD/14-87    AC A0A093PFF9.1
#=GS A0A094KMM9_9AVES/16-90    AC A0A094KMM9.1
#=GS A0A087QSS1_APTFO/3-77     AC A0A087QSS1.1
#=GS A0A093IUS5_EURHL/3-77     AC A0A093IUS5.1
#=GS E9PSH8_HUMAN/30-121       AC E9PSH8.1
#=GS K7ESV7_PONAB/22-104       AC K7ESV7.1
#=GS A0A2C9KNG7_BIOGL/87-159   AC A0A2C9KNG7.1
#=GS G7PP33_MACFA/36-118       AC G7PP33.1
#=GS A0A091P3W2_LEPDC/3-78     AC A0A091P3W2.1
#=GS A0A0G2K986_RAT/24-104     AC A0A0G2K986.1
#=GS A0A093IGG9_FULGA/3-77     AC A0A093IGG9.1
#=GS A0A218UAK5_9PASE/32-104   AC A0A218UAK5.1
#=GS G3QUY7_GORGO/36-127       AC G3QUY7.1
#=GS A0A1V4J820_PATFA/54-129   AC A0A1V4J820.1
#=GS A0A2I2YPJ9_GORGO/30-121   AC A0A2I2YPJ9.1
#=GS A0A2D0SXZ9_ICTPU/61-143   AC A0A2D0SXZ9.1
#=GS H0UW68_CAVPO/36-115       AC H0UW68.1
#=GS H2NFG6_PONAB/36-118       AC H2NFG6.1
#=GS L5KKM4_PTEAL/18-99        AC L5KKM4.1
#=GS G3T782_LOXAF/29-109       AC G3T782.1
#=GS A0A1A6FZD4_NEOLE/7-87     AC A0A1A6FZD4.1
#=GS CD3E_BOVIN/30-112         AC Q28073.2
#=GS A0A091EZF6_CORBR/29-103   AC A0A091EZF6.1
#=GS F1N9E3_CHICK/28-100       AC F1N9E3.1
#=GS A0A1L8FLK6_XENLA/28-100   AC A0A1L8FLK6.1
#=GS A0A094K781_ANTCR/3-77     AC A0A094K781.1
#=GS G1MXY3_MELGA/11-82        AC G1MXY3.2
#=GS U3JTY0_FICAL/36-110       AC U3JTY0.1
#=GS A0A099Z9D0_TINGU/28-102   AC A0A099Z9D0.1
#=GS CD3E_HUMAN/36-127         AC P07766.2
#=GS CD3E_HUMAN/36-127         DR PDB; 1XIW E; 15-98;
#=GS CD3E_HUMAN/36-127         DR PDB; 1XIW A; 15-102;
#=GS CD3E_HUMAN/36-127         DR PDB; 1SY6 A; 121-203;
#=GS F7D784_MONDO/33-114       AC F7D784.2
#=GS K7FZ85_PELSI/1-73         AC K7FZ85.1
#=GS A0A1S3GT34_DIPOR/38-107   AC A0A1S3GT34.1
#=GS CD3E_MOUSE/29-109         AC P22646.2
#=GS CD3E_MOUSE/29-109         DR PDB; 3R08 E; 8-79;
#=GS CD3E_MOUSE/29-109         DR PDB; 1JBJ A; 8-79;
#=GS CD3E_MOUSE/29-109         DR PDB; 1XMW A; 8-79;
#=GS A0A2D0QJK6_ICTPU/664-726  AC A0A2D0QJK6.1
#=GS CD3E_CHICK/28-100         AC Q98910.1
#=GS A0A091HYK7_BUCRH/3-81     AC A0A091HYK7.1
#=GS A0A0Q3LVN9_AMAAE/33-107   AC A0A0Q3LVN9.1
#=GS A0A226P913_COLVI/44-119   AC A0A226P913.1
#=GS A0A0D9S3K3_CHLSB/36-117   AC A0A0D9S3K3.1
#=GS A0A226N537_CALSU/36-111   AC A0A226N537.1
#=GS A0A2I3NE27_PAPAN/36-118   AC A0A2I3NE27.1
#=GS A0A2I3MMG6_PAPAN/30-112   AC A0A2I3MMG6.1
#=GS A0A093FWB8_DRYPU/3-77     AC A0A093FWB8.1
#=GS A0A1U7T8B7_TARSY/36-116   AC A0A1U7T8B7.1
#=GS A0A2D0QHC7_ICTPU/668-730  AC A0A2D0QHC7.1
#=GS G5BHL3_HETGA/31-112       AC G5BHL3.1
#=GS D4A5M2_RAT/24-104         AC D4A5M2.1
#=GS IL12B_MESAU/38-108        AC Q8CJE6.1
#=GS E7F480_DANRE/28-108       AC E7F480.2
#=GS IL12B_CAVPO/38-108        AC Q924V5.1
#=GS A0A093CCU6_TAUER/22-96    AC A0A093CCU6.1
#=GS A0A2D0QIS0_ICTPU/554-616  AC A0A2D0QIS0.1
#=GS A0A2I3HEF8_NOMLE/36-118   AC A0A2I3HEF8.1
#=GS A0A1L8FFY3_XENLA/28-103   AC A0A1L8FFY3.1
#=GS F7CSX8_HORSE/40-119       AC F7CSX8.1
#=GS S7MDL0_MYOBR/26-107       AC S7MDL0.1
#=GS A0A099ZZH2_CHAVO/3-77     AC A0A099ZZH2.1
#=GS F1SAK8_PIG/36-116         AC F1SAK8.2
#=GS A0A091VB92_OPIHO/3-76     AC A0A091VB92.1
#=GS CD3E_CANLF/41-122         AC P27597.1
#=GS A0A1U7TSW6_TARSY/40-108   AC A0A1U7TSW6.1
#=GS S9XK54_CAMFR/28-108       AC S9XK54.1
#=GS A0A2K5K7N2_COLAP/30-112   AC A0A2K5K7N2.1
#=GS G3WKI6_SARHA/41-122       AC G3WKI6.1
#=GS A0A0A0MQ09_FELCA/12-93    AC A0A0A0MQ09.2
#=GS W5PGT2_SHEEP/39-121       AC W5PGT2.1
#=GS A0A2I3TWV1_PANTR/30-121   AC A0A2I3TWV1.1
#=GS A0A091L0Z9_9GRUI/3-78     AC A0A091L0Z9.1
#=GS M7BCU7_CHEMY/56-122       AC M7BCU7.1
#=GS F7G2A3_CALJA/35-117       AC F7G2A3.1
#=GS F8W5C0_DANRE/27-106       AC F8W5C0.1
#=GS H3BFT3_LATCH/1-62         AC H3BFT3.1
#=GS A0A1U8DY31_ALLSI/27-108   AC A0A1U8DY31.1
#=GS H9GCG3_ANOCA/57-136       AC H9GCG3.2
#=GS H2Q4V9_PANTR/36-127       AC H2Q4V9.1
#=GS U3K2L4_FICAL/40-113       AC U3K2L4.1
#=GS L5M0Z4_MYODS/18-99        AC L5M0Z4.1
#=GS A0A140TAW1_RABIT/39-121   AC A0A140TAW1.1
#=GS A0A091S5T6_NESNO/3-77     AC A0A091S5T6.1
#=GS F6Q457_ORNAN/32-111       AC F6Q457.1
#=GS A0A2D0SWY8_ICTPU/28-110   AC A0A2D0SWY8.1
#=GS Q3LRP4_CALJA/36-118       AC Q3LRP4.1
#=GS A0A091JRV7_EGRGA/3-77     AC A0A091JRV7.1
#=GS A0A2D0SXF5_ICTPU/60-142   AC A0A2D0SXF5.1
#=GS A0A091UBN7_PHORB/3-78     AC A0A091UBN7.1
#=GS G1PDF3_MYOLU/38-119       AC G1PDF3.1
#=GS A0A1U7U4U8_TARSY/40-108   AC A0A1U7U4U8.1
#=GS A0A093FR09_GAVST/3-77     AC A0A093FR09.1
#=GS A0A1U7Q2D2_MESAU/38-108   AC A0A1U7Q2D2.1
#=GS A0A2D0QHQ1_ICTPU/664-726  AC A0A2D0QHQ1.1
#=GS A0A1S3EMY9_DIPOR/33-113   AC A0A1S3EMY9.1
#=GS A0A091IJC3_CALAN/3-77     AC A0A091IJC3.1
#=GS M3XJR7_LATCH/37-113       AC M3XJR7.1
#=GS A0A093C490_9AVES/29-103   AC A0A093C490.1
#=GS A0A1S3WBW9_ERIEU/28-104   AC A0A1S3WBW9.1
#=GS A0A091FIN1_9AVES/3-77     AC A0A091FIN1.1
#=GS A0A091VPK1_NIPNI/2-76     AC A0A091VPK1.1
#=GS A0A151PGJ4_ALLMI/27-108   AC A0A151PGJ4.1
#=GS A0A2D0QH04_ICTPU/665-727  AC A0A2D0QH04.1
#=GS A0A1D5QZJ9_MACMU/30-112   AC A0A1D5QZJ9.1
#=GS A0A093HXH5_STRCA/3-77     AC A0A093HXH5.1
#=GS A0A093QMF1_9PASS/3-80     AC A0A093QMF1.1
#=GS U3IT67_ANAPL/38-109       AC U3IT67.1
#=GS A0A218UQ98_9PASE/31-105   AC A0A218UQ98.1
#=GS A0A2K5NWA6_CERAT/36-118   AC A0A2K5NWA6.1
#=GS A0A091DLC2_FUKDA/1-34     AC A0A091DLC2.1
#=GS H0X808_OTOGA/36-118       AC H0X808.1
#=GS A0A091EG52_CORBR/37-110   AC A0A091EG52.1
#=GS A0A1U8BMC1_MESAU/25-104   AC A0A1U8BMC1.1
#=GS G1SRV6_RABIT/8-90         AC G1SRV6.1
#=GS A0A2D0QH08_ICTPU/552-614  AC A0A2D0QH08.1
#=GS F6VBD7_XENTR/46-122       AC F6VBD7.1
#=GS CD3E_SHEEP/30-112         AC P29328.1
#=GS A0A091SDF8_9AVES/18-92    AC A0A091SDF8.1
#=GS A0A2K5K7L6_COLAP/36-118   AC A0A2K5K7L6.1
#=GS A0A2K5NVW0_CERAT/30-112   AC A0A2K5NVW0.1
#=GS A0A093QIC8_PHACA/22-96    AC A0A093QIC8.1
#=GS A0A091N4V0_APAVI/1-75     AC A0A091N4V0.1
#=GS A0A091TNF4_PHALP/18-92    AC A0A091TNF4.1
#=GS A0A093BMH1_CHAPE/3-77     AC A0A093BMH1.1
CD3E_RABIT/36-118                    ..........................................FTVSISGTRVVLTC....PV.EAE...gGDIH...W.ERD...............EKS..LPN....-T.....KKELDLTDFS.EMEH.S.G.YYSC...YVGTK....NKENEHILYLKARVCEACMEVDL.................
A0A093PFF9_PYGAD/14-87               .........................................f-LVEISGTTVTITC....P-.LTG....SNIV...W.SSP...............GRK..SDD....AR.....K--YIIENHD.S--S.P.V.NVTC...SSAG-....---KTYELYLNARVCANCEELD-a................
A0A094KMM9_9AVES/16-90               .........................................f-LVEISGTTVTITC....PL.-TE....GNIV...W.ELS...............GRK..AEG....SD.....QKHTIQDHDS.---S.P.A.NVSC...SSGS-....---DKYEMYLNARVCANCEELD-a................
A0A087QSS1_APTFO/3-77                .........................................f-LVEISGTTVTLTC....P-.LTE....SNVA...W.YLD...............GTK..SDD....NE.....-RKHVIENHN.S--S.P.V.NVSC...SSAD-....---KKYEMYLNARVCANCEELD-a................
A0A093IUS5_EURHL/3-77                ........................................il--VEISGTTVTLTC....P-.VSE....GSIA...W.ELS...............GKK..QDN....-K.....ESKYTIENH-.--DS.S.PlNVRC...SSET-....---TKHELYLNARVCANCEELD-a................
E9PSH8_HUMAN/30-121                  ..........................................YKVSISGTTVILTC....PQ.YPG....SEIL...W.QHNdkni......ggdedDKN..IG-....SD.....EDHLSLKEFS.ELEQ.S.G.YYVC...YPRGS...kPEDANFYLYLRARVCENCMEMDV.................
K7ESV7_PONAB/22-104                  ..........................................YKVSISGTTVILTC....PQ.YPG....SEIL...W.QHN...............DKN..IES....-D.....EDHLSLTGFS.ELEQ.S.G.YYVC...YPKGS...kPEDASFYLYLRARVCENCMEMDV.................
A0A2C9KNG7_BIOGL/87-159              .......................................smp----IKGGRVILTC....GE.KRTd..gTTYT...W.TKD...............AKP..IAR....QF.....DRRLQLDNFD.T-TD.D.G.IYAC...QASGN....-----------------------qfylrsntinlet....
G7PP33_MACFA/36-118                  ..........................................YQVSISGTTVILTC....SQ.HLG....SEAQ...W.QHN...............GKN..KED....-S.....GDRLFLPEFS.EMEQ.S.G.YYVC...YPRGS...nPEDASHHLYLKARVCENCMEMDV.................
A0A091P3W2_LEPDC/3-78                .........................................f-LVEISGTTVTITC....P-.LTE....DNIV...W.EVT...............GTR..LPF....-Q.....ERKYVIENHD.S--S.P.V.NVSC...SADG-....--KKRHEMYLKARVCANCEELD-a................
A0A0G2K986_RAT/24-104                ..........................................YEVSISGTSVELTC....PL.ENE....DNLK...W.EKN...............DKV..LPD....KN.....EKHLVLEDFS.EVKD.S.G.YYVC...YTESS....RK--NTYLYLKARVCENCMEVDL.................
A0A093IGG9_FULGA/3-77                .........................................f-LVEISGTTVTITC....PL.-TE....GSIV...W.ELT...............GIK..ADS....-N.....ERKYVIEHHD.--SS.P.A.NVSC...SSGD-....---KKYEMYLNARVCTNCEELD-a................
A0A218UAK5_9PASE/32-104              .....................................wdaea-----AATTVELSC....A-.SSE....EAVY...W.RKD...............SEG..KQK....--.....GKTLSVA-VK.ELPD.A.G.NYSC...VSEES....HSVLSSSLLLIARI---------gpd..............
G3QUY7_GORGO/36-127                  ..........................................YKVSISGTTVILTC....PQ.YPG....SEIL...W.QHNdkni......ggdedDKN..IG-....SD.....EDHLSLKEFS.ELEQ.S.G.YYVC...YPRGS...kPEDANFYLYLRARVCENCMEMDV.................
A0A1V4J820_PATFA/54-129              .........................................f-LVEISGTTVTITC....PS.SEE....SDIV...W.EIT...............GIK..PTR....-G.....DRKYVIENHD.S--S.P.A.DVNC...SSGG-....---KKHEMHLNVRVCANCQELD-a................
A0A2I2YPJ9_GORGO/30-121              ..........................................YKVSISGTTVILTC....PQ.YPG....SEIL...W.QHNdkni......ggdedDKN..IG-....SD.....EDHLSLKEFS.ELEQ.S.G.YYVC...YPRGS...kPEDANFYLYLRARVCENCMEMDV.................
A0A2D0SXZ9_ICTPU/61-143              .........................................a-DVSISGTTVTLTC....PA.DPE....DTIQ...W.FKY...............AQT..DPLs.lpAE.....TNTYSISNYT.D-KS.D.G.FYYC...SYGA-....-ESKKHHFYIKAKVCEGCVDMDM.................
H0UW68_CAVPO/36-115                  ..........................................YEVSISRSTVTVTC....YL.NPE....EPIE...W.KKD...............NKV..IPN....EN.....NRELIIESFS.ELED.S.G.YYTC...AKSSS....E---KVYLYLKARVCENCMEVNL.................
H2NFG6_PONAB/36-118                  ..........................................YKVSISGTTVILTC....PQ.YPG....SEIL...W.QHN...............DKN..IES....-D.....EDHLSLTGFS.ELEQ.S.G.YYVC...YPKGS...kPEDASFYLYLRARVCENCMEMDV.................
L5KKM4_PTEAL/18-99                   ..........................................YKVSISGTKVMLTC....PE.DSE...sGTII...W.EKD...............GKP..RRT....-N.....EDTLLLENFS.EMED.N.G.YYSC...YTSAS....-KNNRNLLYLKARVCENCMEVDL.................
G3T782_LOXAF/29-109                  ..........................................YKVSISGTRVVLTC....PV.ESE....-QIQ...W.EHN...............KVL..LRA....ES.....EVQLVREYFS.EVEN.S.G.RYSC...CKST-....DKENKHHLYLKARVCESCMEVNL.................
A0A1A6FZD4_NEOLE/7-87                ..........................................YEVSISGTKIELTC....PL.ESD....GVFK...W.EKN...............DKE..LHD....KN.....EKVLVTEKFS.EVED.N.G.YYVC...YSDAS....QK--NAYLYLKARVCENCVEVDL.................
CD3E_BOVIN/30-112                    ..........................................YEVSISGNTVELTC....PR.EFE....GEIH...W.KQN...............DEQ..MKG....YT.....GKQLLLENFS.EMDN.S.G.YYQC...YMTEG....NKEAAHTLYLKARVCQNCMEVNL.................
A0A091EZF6_CORBR/29-103              .........................................f-LVEISGTTVTITC....PL.ED-....EGIK...W.DPS...............GRR..GDI....-E.....EGKFIIKDHD.S--T.P.A.NLSC...SLGN-....---KKHKLYLNARVCANCEELD-a................
F1N9E3_CHICK/28-100                  ..........................................FAVEISGTTVTITC....P-.SSG....DDVK...W.KPD...............PKM..VVN....--.....N-KYIIQN--.-HDS.SpL.TVSC...TAGD-....---EEHTMYLNAKVCANCEELD-t................
A0A1L8FLK6_XENLA/28-100              ..........................................IQVSISRRTVVITC....PA.GKG....-TIK...F.KED...............RSL..TT-....--.....EDNIELTDFA.D-EN.N.G.MYSC...GTQD-....----PAYLYLKAYVCDNCKEVS-i................
A0A094K781_ANTCR/3-77                .........................................f-LVEISSTTVTITC....PL.-TE....GSIA...W.ELT...............GKK..SDN....-K.....ERKYVIENHN.S--S.P.V.NVSC...SSGS-....---EKYEMYLNARVCANCEELD-t................
G1MXY3_MELGA/11-82                   ..........................................FTVEISGTTVTITC....P-.-FS....GEVK...W.KPD...............KLK..TDG....--.....-NKCIIEN--.-HDS.S.PlNVTC...EESN-....---KKLALYLNARVCTNCEELD-t................
U3JTY0_FICAL/36-110                  .........................................f-LVEISGTTVTITC....PF.E-D....EDIR...W.ELS...............GRP..EGT....-R.....ERKLVLKDHD.S--T.P.A.NLSC...SLGT-....---QTRQLYLNARVCANCEELD-a................
A0A099Z9D0_TINGU/28-102              .........................................f-LVEISGTTVTITC....P-.VTE....GTIT...W.DPA...............VIK..PSD....-D.....ETKYIIEDYD.S--S.P.L.NLSC...SSGG-....---KKYAMYLNARVCANCEELD-a................
CD3E_HUMAN/36-127                    ..........................................YKVSISGTTVILTC....PQ.YPG....SEIL...W.QHNdkni......ggdedDKN..IG-....SD.....EDHLSLKEFS.ELEQ.S.G.YYVC...YPRGS...kPEDANFYLYLRARVCENCMEMDV.................
#=GR CD3E_HUMAN/36-127         SS    ..........................................-EEEEETTEEEEE-....ST.STT....S-EE...E.EETTEEE......SSSTS-TT..EE-....EE.....TTEEEETT--.HHHH.-.E.EEEE...EETTS...-GGGSSEEEEEEE--XTTXXXXXX.................
F7D784_MONDO/33-114                  ..........................................FGVSISGTQVTLTC....PE.KSE....DLII...W.KKN...............NVL..ING....VE.....SYQLTLDD-S.ETEY.S.G.HFHC...KKKSS....PSDEGYFLYLKARVCHGCLEMGV.................
K7FZ85_PELSI/1-73                    ..........................................FQVMVSKTTVTLTC....LK.---....SSCT...I.THN...............EKV..TPD....--.....-CTRVIENYK.SSQD.D.G.EYQC...QSSK-....---DTFTLYLKAKVCESCVELD-p................
A0A1S3GT34_DIPOR/38-107              .......................................yld----VPGETVVLTC....DT.EEE....DGII...W.KRS...............DEV..VGT....GK.....SLTVQVK---.EFRS.T.G.HYTC...HKGSE....-----------------------vlghstlllhkken...
CD3E_MOUSE/29-109                    ..........................................YKVSISGTSVELTC....PL.DSD....ENLK...W.EKN...............GQE..LPQ....KH.....DKHLVLQDFS.EVED.S.G.YYVC...YTPAS....NK--NTYLYLKARVCEYCVEVDL.................
#=GR CD3E_MOUSE/29-109         SS    ..........................................-EEEEETTEEEEE-....SS.---....TT-E...E.EET...............TEE..ETT....--.....SSEEEECS--.TTTC.-.E.EEEE...E-SS-....TT---EEEEECTS-XXXXXXXXX.................
A0A2D0QJK6_ICTPU/664-726             .......................................iyp------GANLTLTC....NP.PVN....NSIQ...W.TLD...............GKL..IKD....NS.....NNILQLDNVS.P-DD.S.G.QYEC...TTTV-....-----------------------nempyviw.........
CD3E_CHICK/28-100                    ..........................................FAVEISGTTVTITC....P-.SSG....DDVK...W.KPD...............PKM..VVN....--.....N-KYIIQN--.-HDS.SpL.TVSC...TAGD-....---EEHTMYLNAKVCANCEELD-t................
A0A091HYK7_BUCRH/3-81                .........................................f-LVEISGTTVTITC....P-.LSE....ETIT...W.KKA...............ETQ..LDN....-K.....ERKYVIENHD.S--S.P.A.SVSC...STGAG....EAARTYAMYLNARVCANCEELD-a................
A0A0Q3LVN9_AMAAE/33-107              .........................................f-LVEISGTTVTITC....PL.-TE....GSIA...W.HST...............GTK..GIS....-D.....AQKYVMENHN.S--S.P.V.NLSC...SSGA-....---KKYEMYLNAKVCANCAELD-a................
A0A226P913_COLVI/44-119              .........................................f-VVEISGTTVTITC....P-.LSG....DNIK...W.EPT...............GKK..VID....--.....-NKYVIEDH-.--DS.SpL.SVTC...MENE-....DNKNKRVLYLNARVCANCEELD-t................
A0A0D9S3K3_CHLSB/36-117              ..........................................YKVSISGTTVILTC....SQ.HLG....SEIQ...W.QHN...............GKN..KDS....--.....GDQLFLPEFS.EMEQ.S.G.YYVC...YPRGS...nPEDASHHLYLKARVCENCMEMDV.................
A0A226N537_CALSU/36-111              .........................................f-VVEISGTTVTITC....P-.FSG....DNIK...W.EPT...............GKK..VID....--.....-NKYVIED--.-HDS.S.PlNVTC...MENK-....DNNNKRALYLNARVCANCEELD-t................
A0A2I3NE27_PAPAN/36-118              ..........................................YQVSISGTTVTLTC....SQ.HPG....SEVQ...W.QHN...............GKN..KED....-S.....GYHLFLPEFS.EMEQ.S.G.YYVC...YPRGS...nPEDASHHLYLKARVCENCMEMDV.................
A0A2I3MMG6_PAPAN/30-112              ..........................................YQVSISGTTVTLTC....SQ.HPG....SEVQ...W.QHN...............GKN..KED....-S.....GYHLFLPEFS.EMEQ.S.G.YYVC...YPRGS...nPEDASHHLYLKARVCENCMEMDV.................
A0A093FWB8_DRYPU/3-77                .........................................f-LVEISGTVVTITC....PL.-AE....GSIT...W.ELP...............GRK..PAE....-S.....GEKYTIQD--.-HDS.SpV.NVTC...ASGA-....---KTREMYLNARVCTNCEELD-a................
A0A1U7T8B7_TARSY/36-116              ..........................................YKVSISGTRVVLVC....PL.EVD....SKIK...W.TKN...............GNK..MSN....YH.....EDHLIWEDFS.EVEN.S.G.DYAC...SADN-....-TEASHHIYLKARVCENCIEVDV.................
A0A2D0QHC7_ICTPU/668-730             .......................................iyp------GANLTLTC....NP.PVN....NSIQ...W.TLD...............GKL..IKD....NS.....NNILQLDNVS.P-DD.S.G.QYEC...TTTV-....-----------------------nempyviw.........
G5BHL3_HETGA/31-112                  ..........................................YRVSISGTRVVVTC....FL.DPS...tDPIK...W.EKI...............DGE..ESG....EN.....DEQLIIENFS.EVEH.S.G.YYAC...YKSDS....EK--NHYLYLKARVCENCMEVDL.................
D4A5M2_RAT/24-104                    ..........................................YEVSISGTSVELTC....PL.ENE....DNLK...W.EKN...............DKV..LPD....KN.....EKHLVLEDFS.EVKD.S.G.YYVC...YTESS....RK--NTYLYLKARVCENCMEVDL.................
IL12B_MESAU/38-108                   ......................................spda-----AGERVVLTC....DT.SEE....DDII...W.TSD...............KNS..EAV....GS.....GKTLTIQ-VK.EFSN.A.G.QYTC...HKGGK....TL-SH------------------srlllhkke........
E7F480_DANRE/28-108                  ..........................................FKVGERGTDVILTC....H-.TSE....HEIT...W.KHQdahs......iskisGSE..FEK....IS.....GRTLTLMDLD.E-DQ.I.G.NYTC...WSQQG....LEDYTYLL---------------ldktke...........
IL12B_CAVPO/38-108                   ......................................htda-----PGETVVLTC....NT.AEE....DGIT...W.TSD...............RKS..DIL....GS.....GKTLTIQ-VK.EFED.A.G.GYTC...HKGGE....-----------------------vlsrsqlllhkke....
A0A093CCU6_TAUER/22-96               .........................................f-LVEISGTTVTITC....PL.-TE....GSIA...W.ELA...............GAS..VPT....TE.....RKHV-IEN--.-HDS.S.PiNVSC...SSSD-....---KKHEMYLNARVCANCEELD-a................
A0A2D0QIS0_ICTPU/554-616             .......................................iyp------GANLTLTC....NP.PVN....NSIQ...W.TLD...............GKL..IKD....NS.....NNILQLDNVS.P-DD.S.G.QYEC...TTTV-....-----------------------nempyviw.........
A0A2I3HEF8_NOMLE/36-118              ..........................................YKVSISGTTVIVTC....PQ.YSG....SEIV...W.QHN...............DKI..IKN....-Y.....DDHLSLKEFS.EMEQ.S.G.YYVC...YPRGS...kPEDASFYLYLRARVCENCMEMDV.................
A0A1L8FFY3_XENLA/28-103              .........................................v-QVSISGKTVTITC....PV.GKA....TIMD...-.IKA...............NKE..LTK....--.....EGEFQFTDFS.D-EN.N.G.MYKC...EKES-....--ESSVYLYLKAYVCDNCREVS-i................
F7CSX8_HORSE/40-119                  ..........................................YEVSISGTTVKLTC....PE.NFG....NELV...W.EIN...............DKK..SDK....-K.....DYTLVLENFS.EVEN.S.G.YYIC...YQENS....KK--THYLYLKARVCENCMEVDL.................
S7MDL0_MYOBR/26-107                  ..........................................FKVSISGTRVEVTC....PE.DPD...sEQIK...W.ERN...............GVQ..LTD....QQ.....EEHLLLDNFS.EMEH.S.G.HYTC...YRGNS....NN--RNYLYLKARVCENCMEVDV.................
A0A099ZZH2_CHAVO/3-77                .........................................f-LVEISGTMVTITC....PL.-TE....ETIA...W.KST...............GTK..PPS....-N.....ERKYVIENHD.SFP-.-.T.NVSC...WSGD-....---KKYNMYLNARVCANCEELD-a................
F1SAK8_PIG/36-116                    ..........................................FKVSISGDKVELTC....PE.DPE...sEKMT...W.KRN...............DMQ..IYE....SY.....DNYMLLESFS.EVEN.S.G.YYTC...TVGE-....--KTSHRLYLKARVCENCVEVDL.................
A0A091VB92_OPIHO/3-76                .........................................f-LVEISGTTVTITC....P-.ITE....DRIE...W.QLT...............GTR..VSG....KK.....QHVIDNHDSS.PVN-.-.-.-VSC...SSGD-....---KKHAMYLNARVCANCEELD-t................
CD3E_CANLF/41-122                    ..........................................FKVSISGTEVVVTC....PD.VFG...yDNIK...W.EKN...............DNL..VEG....AS.....NRELSQKEFS.EVDD.S.G.YYAC...YADSI....KE--KSYLYLRARVCANCIEVNL.................
A0A1U7TSW6_TARSY/40-108              .......................................gap------GETVVLTC....DT.PEE....DGIT...W.TSD...............KSS..EVL....GS.....SKTLTIQ-VK.EFED.A.G.RYTC...HKGDE....L--LSHSL---------------lllhkre..........
S9XK54_CAMFR/28-108                  ..........................................YKVSISGNRVELTC....PE.DFE...tEPLT...W.EKN...............NQK..IAD....TY.....EKHLLLDNFS.EMEN.S.G.YYTC...STKE-....--KKSHRIYLKARVCENCVEVDV.................
A0A2K5K7N2_COLAP/30-112              ..........................................YKVSISGTTVILTC....SQ.HLG....SEIQ...W.QHN...............GKN..KED....-S.....GDHLFLREFS.EMEQ.S.G.YYVC...YPRGS...kAEDASHHLYLKARVCENCMEMDV.................
G3WKI6_SARHA/41-122                  ..........................................FGVYISGTEVTLTC....PE.KTN....EEII...W.KKN...............DLT..ING....VD.....TDTLTLKD-S.ETEY.R.G.HFFC...KKKSG....SDTEGYFLYLKARVCDGCMEVEV.................
A0A0A0MQ09_FELCA/12-93               ..........................................YKVSISGTTVVLTC....PE.DLG...sESIK...W.ERN...............GDL..LPN....EY.....GEQLFLDDFS.EMEN.S.G.YYAC...YTSNS....LE--KNYLYLKARVCQNCVEVD-t................
W5PGT2_SHEEP/39-121                  ..........................................YEVSISGNSVELTC....PK.DFE....NGIQ...W.KRN...............NEQ..MKG....HN.....EKYLLLDNFS.EMEN.S.G.YYQC...LATEG....NTEAAHTLYLKARVCKNCMEVNL.................
A0A2I3TWV1_PANTR/30-121              ..........................................YKVSISGTTVILTC....PQ.YPG....SEIL...W.QHNdkni......gsdedDKN..IG-....SD.....EDHLSLKEFS.ELEQ.S.G.YYVC...YPRGS...kPEDANFYLYLRARVCENCMEMDV.................
A0A091L0Z9_9GRUI/3-78                ........................................il--VEISGTTVTLTC....P-.LPE....GTIT...W.TLS...............ETK..QTH....GS.....EQKHVIKNHN.S--S.P.T.SVSC...ASDD-....---KTYEMYLNARVCENCEELDV.................
M7BCU7_CHEMY/56-122                  ..........................................FTVVISKTKVTLTC....PL.--D....EGVT...W.KKE...............GQD..LDA....-K.....DSIYEIEEYE.SSKN.D.G.EYTC...GATGD....----PLKLHLKA-----------kg...............
F7G2A3_CALJA/35-117                  ..........................................YKVSISGTTVTLTC....PR.YDG....HEIK...W.LVN...............SQN..KEG....-H.....EDHLLLEDFS.EMEQ.S.G.YYAC...LSKET...pAEEASHYLYLKARVCENCVEVDV.................
F8W5C0_DANRE/27-106                  .....................................kfger------GTDVILTC....H-.TSE....HEIT...W.KHQdahs......iskisGSE..FEK....IS.....GRTLTLMDLD.E-DQ.I.G.NYTC...WSQQG....LEDYTYLL---------------ldktke...........
H3BFT3_LATCH/1-62                    .........................................t--------------....--.---....DYIK...W.KKD...............DKE..LPKe..lSE.....ANKLEIKNFN.D-DN.N.G.YYGC...SKES-....---SNHTIYVKAKVCENCVKLDV.................
A0A1U8DY31_ALLSI/27-108              .........................................i-DVAISYTTVTLTC....NT.NVLk..tDSIK...W.KKD...............NTD..VQG....SV.....SRENQISNYQ.GSKD.D.G.TYTC...ATDK-....--VTSMPLYLKAKVCENCQELDI.................
H9GCG3_ANOCA/57-136                  ..........................................IKVKQNGRNVTLQC....SG.GSEg..sEPFT...W.EKD...............GHV..LDD....HK.....GELLPLG--S.EMDDpR.G.SFSC...SSGD-....---QTASLQVFFRMCQNCIHLDV.................
H2Q4V9_PANTR/36-127                  ..........................................YKVSISGTTVILTC....PQ.YPG....SEIL...W.QHNdkni......gsdedDKN..IG-....SD.....EDHLSLKEFS.ELEQ.S.G.YYVC...YPRGS...kPEDANFYLYLRARVCENCMEMDV.................
U3K2L4_FICAL/40-113                  .....................................aeapa-------SSVELTC....D-.SSE....EQVY...W.EKD...............SEW..KQE....--.....GKTLTAA-VK.EFPD.A.G.NYSC...LSQQS....HKVLSSHLLLIAKI---------nsqgqm...........
L5M0Z4_MYODS/18-99                   ..........................................FKVSISGTRVEVTC....PE.DPD...sEQIK...W.ERN...............GVQ..LTD....QQ.....EEHLLIDNFS.EMEN.S.G.HYTC...YRGNS....NN--RNYLYLKARVCENCMEVDV.................
A0A140TAW1_RABIT/39-121              ..........................................FTVSISGTRVVLTC....PV.EAE...gGDIH...W.ERD...............EKS..LPN....-T.....KKELDLTDFS.EMEH.S.G.YYSC...YVGTK....NKENEHILYLKARVCEACMEVDL.................
A0A091S5T6_NESNO/3-77                .........................................f-LVEISGTTVTITC....PL.-TE....GSIS...W.QSP...............GTN..GVS....-D.....AHKYIIENHD.S--S.P.I.SVSC...SSSA-....---KKYEMYLHAKVCAKCAELD-a................
F6Q457_ORNAN/32-111                  ...................................hvqyerl------GTDVTLQC....GT.MAW...dAAVT...W.TIN...............GTD..IESs..hLN.....GSRLVLRA-V.DLSQ.S.G.HYSC...YEGAS...wHNKYQVLLHVG------------rkvsg............
A0A2D0SWY8_ICTPU/28-110              .........................................a-DVSISGTTVTLTC....PA.DPE....DTIQ...W.FKY...............AQT..DPLs.lpAE.....TNTYSISNYT.D-KS.D.G.FYYC...SYGA-....-ESKKHHFYIKAKVCEGCVDMDM.................
Q3LRP4_CALJA/36-118                  ..........................................YKVSISGTTVTLTC....PR.YDG....HEIK...W.LVN...............SQN..KEG....-H.....EDHLLLEDFS.EMEQ.S.G.YYAC...LSKET...pAEEASHYLYLKARVCENCVEVDV.................
A0A091JRV7_EGRGA/3-77                .........................................f-LVEISGTTVTITC....PL.-TE....GSVT...W.DLT...............GTK..PEN....-K.....DKKLVLENHD.S--S.P.A.NVSC...SEGA-....---KKYDMYLNARVCANCEELD-t................
A0A2D0SXF5_ICTPU/60-142              .........................................s-DVSISGTTVTLTC....PA.DPE....DTIQ...W.FKY...............AQT..DPLs.lpAE.....TNTYSISNYT.D-KS.D.G.FYYC...SYGA-....-ESKKHHFYIKAKVCEGCVDMDM.................
A0A091UBN7_PHORB/3-78                .........................................f-LVEISGTTVTITC....PV.N-K....DTVT...W.EVN...............GEK..KTH....LK.....ERKYVIDNHD.S--S.T.L.NVSC...SAED-....---KRYELYLNARVCANCEELD-a................
G1PDF3_MYOLU/38-119                  ..........................................FKVSISGTRVEVTC....PE.DPD...sEQIK...W.ERN...............GVQ..LTD....QQ.....EEHLLLDNFS.EMEH.S.G.HYTC...YRGNS....NN--RNYLYLKARVCENCMEVDV.................
A0A1U7U4U8_TARSY/40-108              .......................................gap------GETVVLTC....DT.PEE....DGIT...W.TSD...............KSS..EVL....GS.....SKTLTIQ-VK.EFED.A.G.RYTC...HKGDE....L--LSHSL---------------lllhkre..........
A0A093FR09_GAVST/3-77                .........................................f-LVEISGTTVTITC....P-.LTE....DNIV...W.DSS...............RTK..-PD....TK.....ERKYVIENHD.S--S.P.A.NVSC...SSGD-....---RKYEMYLNARVCENCEELD-a................
A0A1U7Q2D2_MESAU/38-108              ......................................spda-----AGERVVLTC....DT.SEE....DDII...W.TSD...............KNS..EAV....GS.....GKTLTIQ-VK.EFSN.A.G.QYTC...HKGGK....TL-SH------------------srlllhkke........
A0A2D0QHQ1_ICTPU/664-726             .......................................iyp------GANLTLTC....NP.PVN....NSIQ...W.TLD...............GKL..IKD....NS.....NNILQLDNVS.P-DD.S.G.QYEC...TTTV-....-----------------------nempyviw.........
A0A1S3EMY9_DIPOR/33-113              ..........................................YEVSISGSRVTLTC....PL.DPE...sGSLK...W.EKN...............DVV..LPD....-K.....EEQLILPSFS.EMDD.S.G.YYVC...YLSNA....AK--KQYLYLKAKVCDNCVEVDL.................
A0A091IJC3_CALAN/3-77                .........................................f-LVEISGTTVTITC....PL.-TE....GSIA...W.EIT...............GIQ..PES....-K.....ERKYVIENHD.S--S.P.T.NVSC...STDD-....---KKHEMYLNARVCTNCEELD-a................
M3XJR7_LATCH/37-113                  ..........................................VKVEVSGTTVTLTC....P-.--T....DYIK...W.KKD...............DKE..LPKe..lSE.....ANKLEIKNFN.D-DN.N.G.YYGC...SKES-....---SNHTIYVKAKVCENCVKLDV.................
A0A093C490_9AVES/29-103              ..........................................FQVEISGTTVTLTC....PL.D-E....ESIV...W.SLT...............EPK..PAS....-N.....ERKYVIENHD.S--S.P.I.TVSC...SAGN-....---KKYEMYLNARVCANCEELD-a................
A0A1S3WBW9_ERIEU/28-104              ..........................................YKVSISGIKVELTC....PL.DTT....DEIS...W.DTK...............RGK..---....KT.....GHTLTVENFS.ELDD.S.G.YYTC...YTTA-....--KKHHRLYLKARVCENCLEVDL.................
A0A091FIN1_9AVES/3-77                ........................................fl--LEISGTTVTITC....PL.-TE....GSIV...W.DLG...............GTK..PAS....-N.....ERKYVIENHD.S--S.P.T.NVAC...SSGS-....---KKYQMYLNARVCTNCEELD-a................
A0A091VPK1_NIPNI/2-76                .........................................f-LVEISGTTVTITC....P-.VTE....GSIE...W.GIA...............GTK..VET....-S.....GEKYVIENHD.S--A.P.A.NVSC...SAGG-....---KTYDMYLNARVCTNCEELD-a................
A0A151PGJ4_ALLMI/27-108              .........................................i-DVVISYTTVILTC....NI.DRS....DPIT...W.KKD...............NTN..LQGp..vSR.....DNQLEISNYQ.GSKD.D.G.TYTC...AAGT-....--DTSIPLYLKAKVCENCNELDV.................
A0A2D0QH04_ICTPU/665-727             .......................................iyp------GANLTLTC....NP.PVN....NSIQ...W.TLD...............GKL..IKD....NS.....NNILQLDNVS.P-DD.S.G.QYEC...TTTV-....-----------------------nempyviw.........
A0A1D5QZJ9_MACMU/30-112              ..........................................YHVSISGTTVILTC....SQ.HLG....SEVQ...W.QHN...............GKN..KED....-S.....GDRLFLPEFS.EMEQ.S.G.YYVC...YPRGS...nPEDASHHLYLKARVCENCMEMDV.................
A0A093HXH5_STRCA/3-77                .........................................f-LVEISGTTVTITC....P-.VTE....GNIV...W.TST...............LLE..ASS....-R.....ERKYVIENY-.--DS.S.P.VYVG...CSSG-....--DQKHKMYLNARVCTNCEELD-a................
A0A093QMF1_9PASS/3-80                .........................................f-LVEISGTTVTITC....PL.-AE....DDVV...W.KST...............GGK..AGT....SN.....ERKYIITDHD.S--S.P.A.NLSC...SSDSS....G--TRHELYLNARVCANCEELD-a................
U3IT67_ANAPL/38-109                  .........................................l-QVEISGTTVEVRC....P-.-SS....ETVQ...W.KPK...............SPD..T--....--.....ENDVFIKK--.NHDSsP.L.NLTC...TAGN-....---KDIHMYLKARVCTNCRELD-t................
A0A218UQ98_9PASE/31-105              .........................................f-LVEISGTTVTITC....PL.EHE....-SIR...W.ELA...............GKV..QDT....-T.....ERKLILKDHD.S--A.P.A.NLSC...GEGTG....----KRQLYLNARVCATCEELD-a................
A0A2K5NWA6_CERAT/36-118              ..........................................YQVSISGTTVTLTC....SQ.HLG....SEVQ...W.QHN...............GKK..RED....-S.....GDHLFLPEFS.EMEQ.S.G.YYVC...YPRGS...nPEDASHHLYLKARVCENCMEMDV.................
A0A091DLC2_FUKDA/1-34                ..........................................--------------....--.---....----...-.---...............---..---....--.....----------.-MEH.S.G.YYVC...YTDN-....--EKSHYLYLKARVCENCMEVDL.................
H0X808_OTOGA/36-118                  ..........................................YKVSISGTTVTVKC....PL.DTE....HDIN...W.AKK...............DQE..LKD...yKN.....QEDLILDNFS.EMEN.S.G.YYAC...YTGN-....KDDISHYLYLRARVCENCMEVDV.................
A0A091EG52_CORBR/37-110              .....................................naeap------ATTVELTC....N-.TSE....EAVY...W.KKD...............SEW..KQE....--.....GKTLTAA-VK.EFPD.A.G.NYTC...LSQES....HEVLDSNLLLIAKI---------dskgq............
A0A1U8BMC1_MESAU/25-104              ..........................................YKVSISGTRIELTC....PL.ESD....-FIH...W.EKN...............DKV..LPE....EN.....EKTLVLQDFS.EVGD.S.G.YYAC...YLESS....EK--NAYLYLKARVCENCVEVDL.................
G1SRV6_RABIT/8-90                    ..........................................FAVSISGNHVVLTC....PV.EAD...aGDIH...W.GKD...............EKS..LPD....-T.....DKELDLENFS.EMEH.S.G.YYSC...YVGTK....NKENQHILYLKARVCEACMEVDL.................
A0A2D0QH08_ICTPU/552-614             .......................................iyp------GANLTLTC....NP.PVN....NSIQ...W.TLD...............GKL..IKD....NS.....NNILQLDNVS.P-DD.S.G.QYEC...TTTV-....-----------------------nempyviw.........
F6VBD7_XENTR/46-122                  ..........................................VKVSISGRTVKIMC....P-.-LE....KQII...M.NKA...............KTE..LAK....--.....QGNLELLEFT.D-EN.N.G.MYQC...MENE-....KDDSPAYLYLKAYVCDNCREVS-i................
CD3E_SHEEP/30-112                    ..........................................YEVSISGNSVELTC....PK.DFE....NGIQ...W.KRN...............NEQ..MKG....HN.....EKYLLLDQFS.EMES.S.G.YYQC...LATEG....NTEAAHTLYLKARVCKNCMEVNL.................
A0A091SDF8_9AVES/18-92               .........................................f-LVEISGTTVTITC....P-.LSE....DKVT...W.QQN...............GKN..LEF....-N.....EAKYIIENHD.S--S.P.V.NLSC...SSGG-....---EKHEMYLNARVCANCEELD-a................
A0A2K5K7L6_COLAP/36-118              ..........................................YKVSISGTTVILTC....SQ.HLG....SEIQ...W.QHN...............GKN..KED....-S.....GDHLFLREFS.EMEQ.S.G.YYVC...YPRGS...kAEDASHHLYLKARVCENCMEMDV.................
A0A2K5NVW0_CERAT/30-112              ..........................................YQVSISGTTVTLTC....SQ.HLG....SEVQ...W.QHN...............GKK..RED....-S.....GDHLFLPEFS.EMEQ.S.G.YYVC...YPRGS...nPEDASHHLYLKARVCENCMEMDV.................
A0A093QIC8_PHACA/22-96               ..........................................FQVEISGTTVTITC....PL.-SE....GDIS...W.KTT...............GTT..PTP....-K.....ERTYVIKDHD.SFP-.-.L.NVSC...SANG-....---VEYDMYLNARVCANCEELD-t................
A0A091N4V0_APAVI/1-75                .........................................f-LVEISGTTVTITC....PL.-TE....GSIE...W.ETP...............APK..-PD....SG.....ERKYVIENHD.S--S.P.A.NVTC...QSGA-....---EKHQLYLNARVCANCEELD-a................
A0A091TNF4_PHALP/18-92               .........................................f-LVEISGTTVTITC....PL.-TE....GSIA...W.ELT...............GTK..LAS....-S.....ETKYVIENHD.S--S.P.A.NVSC...SSGG-....---KKYELYLNARVCTNCEELD-a................
A0A093BMH1_CHAPE/3-77                ........................................ll--VEISGTTVTITC....PL.-TE....GRIE...W.DLS...............GKK..QEG....-D.....ERKYVLENH-.--DS.S.PiNVSC...SSNQ-....---EKYNMYLHARVCANCEELD-a................
#=GC SS_cons                         ..........................................-EEEEETTEEEEE-....ST.STT....TTEE...E.EETTEEE......SSSTSTCC..ECT....EE.....TTEEEECT--.CCCC.-.E.EEEE...EETTS....CCGSSEEEEECCS-XTTXXXXXX.................
#=GC seq_cons                        ............................................VpISGTTVslTC....P...sp....ssIp...W.pps...............spp..hts.....p.....pccLhlcsas.p.-s.s.G..YsC...hsss........tpahLYLpARVCtNC.ElD..................
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