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Database: Pfam
Entry: Inhibitor_I24
LinkDB: Inhibitor_I24
Original site: Inhibitor_I24 
#=GF ID   Inhibitor_I24
#=GF AC   PF10465.10
#=GF DE   PinA peptidase inhibitor 
#=GF PI   Peptidase_I24; 
#=GF AU   Rawlings ND;0000-0001-5557-7665
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF SE   Manual
#=GF GA   25.00 25.00;
#=GF TC   31.90 31.70;
#=GF NC   22.20 20.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Protease_inhibitor_(biology)
#=GF RN   [1]
#=GF RM   2838455
#=GF RT   A bacteriophage T4 gene which functions to inhibit Escherichia
#=GF RT   coli Lon protease. 
#=GF RA   Skorupski K, Tomaschewski J, Ruger W, Simon LD; 
#=GF RL   J Bacteriol. 1988;170:3016-3024.
#=GF RN   [2]
#=GF RM   9417110
#=GF RT   Isolation and characterization of the phage T4 PinA protein, an
#=GF RT   inhibitor of the ATP-dependent lon protease of Escherichia coli. 
#=GF RA   Hilliard JJ, Maurizi MR, Simon LD; 
#=GF RL   J Biol Chem. 1998;273:518-523.
#=GF DR   INTERPRO; IPR019506;
#=GF DR   MEROPS; I24;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   PinA inhibits the endopeptidase La.  It binds to the La
#=GF CC   homotetramer but does not interfere with the ATP binding site or
#=GF CC   the active site of La.
#=GF SQ   21
#=GS A0A411BIM3_9CAUD/1-109   AC A0A411BIM3.1
#=GS A0A023W4S2_9CAUD/8-56    AC A0A023W4S2.1
#=GS A0A1B1P8U0_9CAUD/3-146   AC A0A1B1P8U0.1
#=GS A0A0A0YVE6_9CAUD/3-138   AC A0A0A0YVE6.1
#=GS A0A2Z5ZCD8_9CAUD/4-146   AC A0A2Z5ZCD8.1
#=GS A0A2R3ZX09_9CAUD/3-146   AC A0A2R3ZX09.1
#=GS Q7Y555_BPR69/6-137       AC Q7Y555.1
#=GS A0A2S1GM97_9CAUD/3-156   AC A0A2S1GM97.1
#=GS A0A0A0Q3D7_9CAUD/3-135   AC A0A0A0Q3D7.1
#=GS A0A2Z4QCY6_9CAUD/6-136   AC A0A2Z4QCY6.1
#=GS A0A0B6VSM5_9CAUD/3-133   AC A0A0B6VSM5.1
#=GS A0A1Z1LY93_9CAUD/10-151  AC A0A1Z1LY93.1
#=GS A0A159B7S5_9CAUD/3-146   AC A0A159B7S5.1
#=GS A0A2K9V5K1_9CAUD/3-146   AC A0A2K9V5K1.1
#=GS Q06EP7_BPR32/3-142       AC Q06EP7.1
#=GS E5DI82_9CAUD/3-149       AC E5DI82.1
#=GS I7J3W9_9CAUD/8-143       AC I7J3W9.1
#=GS A0A2I6UFD3_9CAUD/1-140   AC A0A2I6UFD3.1
#=GS A0A1B0VV45_9CAUD/3-135   AC A0A1B0VV45.1
#=GS PIN_BPT4/3-142           AC P07068.1
#=GS A0A0B5A2D3_9CAUD/5-122   AC A0A0B5A2D3.1
A0A411BIM3_9CAUD/1-109              ..............mlh---KSYIIRK..EYK.DLSDKFPELVVGASFEVLTIVKR-----EYYTGATT..IKMiNTGTIY........NI.EDR.D...TH......LWCFYTN.....AMIGN..GEIEEI..TV.--.-.-...--.-.-.----..-----..-...----------..--------------------------yqqretpktvretpktamdiwehqekl
A0A023W4S2_9CAUD/8-56               .......ialshfggke----------..---.------------------------------------..---.------........--.---.-...--......-------.....-----..------..--.--.-.-...--.-.-.----..---VK..I...SAALYSLAAQ..ENNDGDEGNLMQKAADYIVWLEEQL-e..........................
A0A1B1P8U0_9CAUD/3-146              ...............li--GKQFEVIE..NDD.ELSEQFPMFIPGFKFQVISVA--NEDDLEMCGITAV..IDL.LTNKII........TI.NDPtPhgeSW......FWCFYSE.....DTMHQ..--IKEIgqGE.DV.P.L...IS.E.I.KLNH..FQGAIvpI...TRALYAFAGQ..ENCDSEEYALMQKAADYIVALEQR--lg.........................
A0A0A0YVE6_9CAUD/3-138              ................l-VNKCFKIVKedNDG.GVFDIYPELTIGTEFKVLSVDKEN-----PD-GITS..ILI.KNGPYL........HI.GSR.E...SW......YWCFWEQ.....DTM--..GEIEEI..EE.LS.S.D...HY.K.I.PDTAhlFKGRD..I...ASQLFKVAGA..ENCDAEEHDLMQAAGEYIRQLEAQL-k..........................
A0A2Z5ZCD8_9CAUD/4-146              ................l-VGKQYEVIK..EDE.ELIKQFPELVKGFRFQV---LTDAEDGYSGTRLVITsvICL.DTAKVI........RI.IDN.P...DS.....wFYCFWCN.....DNIL-..SELQEI..GH.GDpV.A...GM.N.E.IKLN.hFGGKIvpI...SMALRAFAGQ..ENCDSEEYDTMQKAAEYIVHLEG---lln........................
A0A2R3ZX09_9CAUD/3-146              ...............fl--NKVFRVIE..EDE.ELLSQFPEFVKGAEFKVLSISKVGES-----TGMTS..VQF.KNGPYVhvktathpEI.SGQ.D...SW......FWCFYSD.....EIDHL..EELEEL..SSdQY.G.S...SE.D.V.PRNL..FNGKD..I...TAQLYKMAGQ..ENCDSEEYDLMQAAADYIRWLESQL-e..........................
Q7Y555_BPR69/6-137                  ...............tr--GKWFKIVK..EDE.ELQVKFPELKKGTIIKVIG---TTTEDGYGDHGIIE..VML.NTGEKL........CI.YDR.D...TS......LWCFWES.....HSID-..-ELEEI..--.--.D.Q...VVcD.G.GLGE..FEGER..I...SYALAKLAAQ..ENNDGYEGNLMQAAAEYIEYLERRLS...........................
A0A2S1GM97_9CAUD/3-156              ...............yi--GKCYRLLE..DDE.ETIAQWPEIKTGFEFQILRTEGTIYSDAVGVTKLMC..LRT.SKIFDI........NFkLEN.P...VDendepwFWCIIHMrdskiEEINA..PNISYP..IK.ET.P.Q...IG.K.I.RLNH..FHGHEvdI...AYALSAFAAQ..EGCDSEEYDLMQAASEYIRELESR--lk.........................
A0A0A0Q3D7_9CAUD/3-135              ................l-VNKCFKIIE..EDTdGVLECFPELRLGTEFKVINM----EDD-----GVTG..ILL.KNGQYL........HI.SSR.E...SM......FWCFWNS.....YNIEEelQEIEDF..TS.GQ.N.I...IN.T.S.DSAD.lFYGLP..I...LEQLESLKSR..VNS--HDERLIVSTIDYIKSLKS---nln........................
A0A2Z4QCY6_9CAUD/6-136              ...............tr--GKWFKIVK..EDE.ELQVKFPELKKGTIIKVIGISTTA----DLASGIVE..VML.STGEKL........CI.HDR.D...IG......FWCFWES.....NSID-..-ELEEI..--.--.D.Q...VV.CgS.ELGE..FEGER..I...SYALAKLAAQ..ENNDGYEGNLMQAAAEYIEYLERRLS...........................
A0A0B6VSM5_9CAUD/3-133              ................l-VDKVFEIVE..DDE.ELLIQFPEMKKGVTFKVVAVD------NDHADGITA..VQI.RNGKYI........HI.NSK.D...SW......FWCFYCG.....DTMHQ.lKEVEEL..A-.-S.D.F...WP.A.K.PMNT..FDGME..I...TVRLEE--AK..TRVNGYEANLMQCAADYIRQLEKR--le.........................
A0A1Z1LY93_9CAUD/10-151             ...............li--GKQFKVVK..EDP.ELITQFPELVKGFKFQVISDDKENRGCSDAITGVIC..--L.KTGKFI........TI.KDN.P...NS.....wFWCFWFN.....ESID-..TELEEI..GS.GD.P.I...AArN.E.IKLN..HFGGR..IvplTLALSSFAAQ..ENCDSEEYDTMQKAAEYITYLEG---ivn........................
A0A159B7S5_9CAUD/3-146              ...............li--GKQFEVIE..NDD.ELSEQFPMFIPGFKFQVISVA--NEDDLEMCGITAV..IDL.LTNKII........TI.NDPtPhgeSW......FWCFYSE.....DTMHQ..--IKEIgqGE.DV.P.L...IS.E.I.KLNH..FQGAIvpI...TRALYAFAGQ..ENCDSEEYDLMQKAADYIVALEQR--lg.........................
A0A2K9V5K1_9CAUD/3-146              ...............li--GKQFEVIE..NDD.ELSEQFPMFIPGFKFQ--VISADNEDDLELVGITAV..IDL.LTNKII........TI.NDPtPhgeSW......FWCFYSE.....DTMHQ..--IKEIgqGE.DV.P.L...IS.E.I.KLNH..FQGAIvpI...TRALYAFAGQ..ENCDSEEYDLMQKAADYIVALEQR--lg.........................
Q06EP7_BPR32/3-142                  .................TVDKWFRINR..ADT.GLCNYWPELSAGTVFKVRELTKECEDDIEPDTGIIE..IEL.SGGKII........NI.YDK.P...IT......YWCLWNT.....ESVEN..GEIEEV..VE.RT.N.Q...VV.Q.K.PEAS..FQGER..I...SYALAKLAAQ..ENNDGYEGNLMQAAAEYIEWLETQNS...........................
E5DI82_9CAUD/3-149                  ...............fl--NKVFRVIA..EDE.ELLSQFPEFVKGAEFKVLSISKVGES-----TGMTS..VQF.KNGPYVhvktathpEI.SGQ.D...SW......FWCFYSD.....EIDHL..EELEEL..EE.LS.SdQygsSG.D.I.PRNL..FNGKD..I...TAQLYKMAGQ..ENCDSEEYDLMQAAADYIRWLEAQL-e..........................
I7J3W9_9CAUD/8-143                  ......ykiigedfdsg----------..--S.GTVVYHPEFKKGAEFKVVKI-----EERRWVTGITA..VQF.RDGPLI........DI.AEF.P...NS.....pFWAFYVD.....NEMAHliEQFEEI..SS.DP.I.E...VI.N.R.I-NM..YAGRP..I...ALALDKMASQ..ENCDTEEYDLMVKAAAYIRWLEKE--ld.........................
A0A2I6UFD3_9CAUD/1-140              .migkcfeivkednedg----------..--Y.GTSVLFPQLKVGVKFKVLRT--GAE-ESCHHHGIKS..IIL.EDGTVI........DI.DSV.D...SS......FWCLWAP.....ASMD-..-EIKEI..PP.ES.F.G...SI.A.-.STGY..FDGQY..L...PDRLKRIEREfdAEYNYYDANVIKATIEHIKWLEAQL-r..........................
A0A1B0VV45_9CAUD/3-135              ................l-VNKVFEIIE..DDE.ELLEQFPEMKVGTVFKVITVDKENG----HEDGITS..VKI.KNGPYL........HI.NAR.D...SW......FWCFYCD.....DGMYQ.lKEIEE-..--.HD.S.D...LF.P.AvTLGF..FDGQL..I...TDHLE--AAK..IRVNGYEANIMQAAADYIRALEKQLS...........................
PIN_BPT4/3-142                      .................TVDKWFRINR..ADT.GLCNYWPELSAGTVFKVRELVKECEDDIEPDTGIIE..IEL.SDGKII........NI.YDK.P...IT......YWCLWNT.....ESVEN..GEIEEV..VE.RT.N.Q...VV.Q.K.PKAD..FQGER..I...SYALAKLAAQ..ENNDGYEGNLMQAAAEYIEWLETQIS...........................
A0A0B5A2D3_9CAUD/5-122              qnsrkvaefkvvkieer----------..---.----------------------------RWATGITA..VQF.RDGPLI........DI.TEF.T..nSL......FWAFYVD.....NDMAHliEQIEEI..SS.DP.I.E...VI.N.D.F-NM..YAGRP..I...ALALDKMASQ..ENCDTEEYDLMVKAAAYIRWLEKE--ld.........................
#=GC seq_cons                       ................h..sK.Fcllc..pDp.-L.ppFPEhhhGspFcVlsls..stt..phssGlss..lpl.psGphl........sI.p-p.s...oh......FWCFass.....-shc...tElEEl..sp.ts.s.t...hh.p.h..hst..FpGp...I...ohALtphAuQ..ENsDucEhsLMQtAA-YIchLEpp.............................
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