GenomeNet

Database: Pfam
Entry: Insulin_TMD
LinkDB: Insulin_TMD
Original site: Insulin_TMD 
#=GF ID   Insulin_TMD
#=GF AC   PF17870.2
#=GF DE   Insulin receptor trans-membrane segment
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF00049
#=GF GA   33.40 33.40;
#=GF TC   33.40 35.70;
#=GF NC   31.40 33.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   24440425
#=GF RT   Solution structure of the transmembrane domain of the insulin
#=GF RT   receptor in detergent micelles.
#=GF RA   Li Q, Wong YL, Kang C;
#=GF RL   Biochim Biophys Acta. 2014;1838:1313-1321.
#=GF DR   INTERPRO; IPR040969;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This entry represents the trans-membrane domain (TMD) found in
#=GF CC   insulin receptor proteins. The TMD of the insulin receptor is
#=GF CC   within the beta-subunit and contains 23 amino acids. Mutations
#=GF CC   in the TMD were shown to have effects on receptor biosynthetic
#=GF CC   processing and kinase activation. Substitution of the entire TMD
#=GF CC   of the insulin receptor (IR) resulted in constitutive kinase
#=GF CC   activation in vitro, while replacing the TMD with that of
#=GF CC   glycophorin A inhibited insulin action. Structural studies show
#=GF CC   that TMD contains a helix and a kink when it is purified in
#=GF CC   dodecylphosphocholine (DPC) micelles. The residues 942-948
#=GF CC   preceding the TMD have a propensity to be a short helix and may
#=GF CC   interact with membrane [1].
#=GF SQ   259
#=GS G3T361_LOXAF/914-961        AC G3T361.1
#=GS A0A3B3BZV3_ORYME/942-986    AC A0A3B3BZV3.1
#=GS A0A3Q1BU58_AMPOC/854-897    AC A0A3Q1BU58.1
#=GS A0A226MM59_CALSU/717-763    AC A0A226MM59.1
#=GS A0A2Y9R3E1_TRIMA/614-661    AC A0A2Y9R3E1.1
#=GS A0A3M0K186_HIRRU/1266-1312  AC A0A3M0K186.1
#=GS G3W0M2_SARHA/94-140         AC G3W0M2.1
#=GS H2NX99_PONAB/889-936        AC H2NX99.1
#=GS A0A3Q2WEL1_HAPBU/935-979    AC A0A3Q2WEL1.1
#=GS A0A091GU13_9AVES/892-938    AC A0A091GU13.1
#=GS A0A3Q4BY16_MOLML/910-956    AC A0A3Q4BY16.1
#=GS A0A3P8W3R3_CYNSE/937-981    AC A0A3P8W3R3.1
#=GS A0A3Q3L1Q2_9TELE/904-948    AC A0A3Q3L1Q2.1
#=GS A0A060XKT4_ONCMY/210-254    AC A0A060XKT4.1
#=GS A0A3B4BWB3_PYGNA/853-899    AC A0A3B4BWB3.1
#=GS A0A3P9A2V0_ESOLU/865-912    AC A0A3P9A2V0.1
#=GS A0A3Q3BJC8_KRYMA/932-976    AC A0A3Q3BJC8.1
#=GS A0A0A0MW86_PAPAN/907-954    AC A0A0A0MW86.2
#=GS A0A3Q3EMI1_9LABR/869-915    AC A0A3Q3EMI1.1
#=GS A0A3Q1DGV6_AMPOC/931-977    AC A0A3Q1DGV6.1
#=GS A0A455B2W6_PHYMC/71-118     AC A0A455B2W6.1
#=GS A0A3B1J7U9_ASTMX/922-969    AC A0A3B1J7U9.1
#=GS J9NY09_CANLF/902-949        AC J9NY09.1
#=GS A0A3Q3X5C5_MOLML/924-970    AC A0A3Q3X5C5.1
#=GS A0A2U3WSM4_ODORO/939-986    AC A0A2U3WSM4.1
#=GS A0A2K6T1C8_SAIBB/940-987    AC A0A2K6T1C8.1
#=GS A0A3B5PVH2_XIPMA/900-946    AC A0A3B5PVH2.1
#=GS A0A099Z5W3_TINGU/904-950    AC A0A099Z5W3.1
#=GS G1PNP3_MYOLU/899-945        AC G1PNP3.1
#=GS L5KC78_PTEAL/772-819        AC L5KC78.1
#=GS A0A3Q4HDN3_NEOBR/856-897    AC A0A3Q4HDN3.1
#=GS A0A151NYD6_ALLMI/904-950    AC A0A151NYD6.1
#=GS A0A3B4FJD9_9CICH/929-975    AC A0A3B4FJD9.1
#=GS A0A452IPX3_9SAUR/889-935    AC A0A452IPX3.1
#=GS A0A1U8DJE2_ALLSI/899-945    AC A0A1U8DJE2.2
#=GS A0A455B503_PHYMC/71-117     AC A0A455B503.1
#=GS A0A091J0U9_EGRGA/902-948    AC A0A091J0U9.1
#=GS T2CB11_RAT/942-989          AC T2CB11.1
#=GS A0A3Q2ECP6_CYPVA/925-971    AC A0A3Q2ECP6.1
#=GS A0A3P8TX69_AMPPE/927-970    AC A0A3P8TX69.1
#=GS A0A2K5L4E5_CERAT/897-944    AC A0A2K5L4E5.1
#=GS H2QF61_PANTR/949-996        AC H2QF61.2
#=GS U3KHF2_FICAL/887-933        AC U3KHF2.1
#=GS F1QNX5_DANRE/917-963        AC F1QNX5.1
#=GS A0A3B4T7Q3_SERDU/935-979    AC A0A3B4T7Q3.1
#=GS A0A3P8PHL2_ASTCA/929-975    AC A0A3P8PHL2.1
#=GS W5M9H7_LEPOC/929-975        AC W5M9H7.1
#=GS A0A2K6T1L4_SAIBB/946-993    AC A0A2K6T1L4.1
#=GS A0A2K5YPC1_MANLE/859-906    AC A0A2K5YPC1.1
#=GS A0A2I3NG96_PAPAN/932-979    AC A0A2I3NG96.1
#=GS A0A3Q1MJC8_BOVIN/921-968    AC A0A3Q1MJC8.1
#=GS A0A2K6B0Q0_MACNE/864-911    AC A0A2K6B0Q0.1
#=GS F6R9D2_HORSE/928-975        AC F6R9D2.2
#=GS A0A3P9DDV5_9CICH/929-975    AC A0A3P9DDV5.1
#=GS A0A3Q2DGV9_CYPVA/931-975    AC A0A3Q2DGV9.1
#=GS A0A091F769_CORBR/905-951    AC A0A091F769.1
#=GS A0A3Q3L1B4_9TELE/896-942    AC A0A3Q3L1B4.1
#=GS K7CJP0_PANTR/940-987        AC K7CJP0.1
#=GS A0A498NEN4_LABRO/979-1022   AC A0A498NEN4.1
#=GS A0A0Q3Q2Q0_AMAAE/888-934    AC A0A0Q3Q2Q0.1
#=GS A0A3P8QPT8_ASTCA/970-1010   AC A0A3P8QPT8.1
#=GS A0A452EK73_CAPHI/911-958    AC A0A452EK73.1
#=GS A0A0P7UK52_SCLFO/708-753    AC A0A0P7UK52.1
#=GS U3FCC1_CALJA/940-987        AC U3FCC1.1
#=GS A0A2U9C2U4_SCOMX/935-979    AC A0A2U9C2U4.1
#=GS A0A3Q3X596_MOLML/891-931    AC A0A3Q3X596.1
#=GS A0A3Q1MJG0_BOVIN/902-949    AC A0A3Q1MJG0.1
#=GS A0A2U3WSD9_ODORO/927-974    AC A0A2U3WSD9.1
#=GS A0A1V4KQM4_PATFA/887-933    AC A0A1V4KQM4.1
#=GS A0A3Q0H314_ALLSI/916-962    AC A0A3Q0H314.1
#=GS A0A2R8ZZ37_PANPA/900-947    AC A0A2R8ZZ37.1
#=GS A0A1U7US90_TARSY/903-950    AC A0A1U7US90.1
#=GS U3CV09_CALJA/928-975        AC U3CV09.1
#=GS G3P8C9_GASAC/931-975        AC G3P8C9.1
#=GS A0A3B4FIM7_9CICH/871-912    AC A0A3B4FIM7.1
#=GS A0A3P8QRD1_ASTCA/935-979    AC A0A3P8QRD1.1
#=GS A0A2K6LLA6_RHIBE/929-976    AC A0A2K6LLA6.1
#=GS A0A3L8RYA5_CHLGU/606-652    AC A0A3L8RYA5.1
#=GS A0A452RT86_URSAM/630-677    AC A0A452RT86.1
#=GS A0A287D4G1_ICTTR/893-940    AC A0A287D4G1.1
#=GS G3UEM7_LOXAF/929-976        AC G3UEM7.1
#=GS A0A3Q1HVV1_ANATE/907-951    AC A0A3Q1HVV1.1
#=GS H0YQ96_TAEGU/904-950        AC H0YQ96.1
#=GS A0A1S3WNI0_ERIEU/890-936    AC A0A1S3WNI0.1
#=GS A0A3Q3X8D1_MOLML/919-959    AC A0A3Q3X8D1.1
#=GS A0A3Q3BJS4_KRYMA/917-963    AC A0A3Q3BJS4.1
#=GS A0A2K5YPE3_MANLE/847-894    AC A0A2K5YPE3.1
#=GS A0A3B5A4N8_9TELE/688-729    AC A0A3B5A4N8.1
#=GS A0A452RTB6_URSAM/618-665    AC A0A452RTB6.1
#=GS F7HRK0_CALJA/931-978        AC F7HRK0.2
#=GS A0A2Y9L836_ENHLU/939-986    AC A0A2Y9L836.1
#=GS A0A3L8RZM3_CHLGU/606-652    AC A0A3L8RZM3.1
#=GS A0A3P9DTK9_9CICH/935-979    AC A0A3P9DTK9.1
#=GS A0A498NNJ9_LABRO/918-965    AC A0A498NNJ9.1
#=GS I3J076_ORENI/935-979        AC I3J076.1
#=GS G1QHT7_NOMLE/830-877        AC G1QHT7.3
#=GS A0A2K5K0Z5_COLAP/907-954    AC A0A2K5K0Z5.1
#=GS M3YAM5_MUSPF/910-957        AC M3YAM5.1
#=GS H2U2E9_TAKRU/932-976        AC H2U2E9.1
#=GS INSR_MOUSE/930-977          AC P15208.2
#=GS A0A3B3Z515_9TELE/922-966    AC A0A3B3Z515.1
#=GS A0A2K6QQB2_RHIRO/928-975    AC A0A2K6QQB2.1
#=GS F6TEA3_XENTR/892-936        AC F6TEA3.1
#=GS R0KN44_ANAPL/892-938        AC R0KN44.1
#=GS Q1LVG4_DANRE/915-958        AC Q1LVG4.3
#=GS A0A0D9R902_CHLSB/943-990    AC A0A0D9R902.1
#=GS A0A1S3P971_SALSA/924-968    AC A0A1S3P971.1
#=GS G3RCY5_GORGO/893-940        AC G3RCY5.2
#=GS A0A3B3YNW5_9TELE/916-962    AC A0A3B3YNW5.1
#=GS A0A3Q0H234_ALLSI/764-810    AC A0A3Q0H234.1
#=GS A0A3B4XQ05_SERLL/931-977    AC A0A3B4XQ05.1
#=GS F6S8L3_MACMU/707-754        AC F6S8L3.2
#=GS A0A3Q3X8C2_MOLML/934-980    AC A0A3Q3X8C2.1
#=GS A0A3Q1JA29_ANATE/938-982    AC A0A3Q1JA29.1
#=GS A0A2K6QQC1_RHIRO/891-938    AC A0A2K6QQC1.1
#=GS H3A6S8_LATCH/402-448        AC H3A6S8.2
#=GS A0A3Q1ECC2_9TELE/886-927    AC A0A3Q1ECC2.1
#=GS A0A2I4B558_9TELE/928-974    AC A0A2I4B558.1
#=GS A0A2U9BIC6_SCOMX/922-968    AC A0A2U9BIC6.1
#=GS M4AW90_XIPMA/922-966        AC M4AW90.2
#=GS E2RPM8_CANLF/931-978        AC E2RPM8.2
#=GS A0A0A0A3W1_CHAVO/902-948    AC A0A0A0A3W1.1
#=GS F7EVG8_ORNAN/718-764        AC F7EVG8.1
#=GS A0A2R9A069_PANPA/920-967    AC A0A2R9A069.1
#=GS K7F279_PELSI/608-654        AC K7F279.1
#=GS A0A3B4ALX4_9GOBI/878-923    AC A0A3B4ALX4.1
#=GS A0A2Y9L5F9_ENHLU/927-973    AC A0A2Y9L5F9.1
#=GS A0A087XET4_POEFO/916-962    AC A0A087XET4.2
#=GS A0A087Y256_POEFO/922-966    AC A0A087Y256.2
#=GS H0VMQ0_CAVPO/929-976        AC H0VMQ0.2
#=GS W5NQ40_SHEEP/911-958        AC W5NQ40.1
#=GS A0A226NZW7_COLVI/738-784    AC A0A226NZW7.1
#=GS A0A1S3KK98_SALSA/762-806    AC A0A1S3KK98.1
#=GS A0A3Q7R5Q5_VULVU/1038-1085  AC A0A3Q7R5Q5.1
#=GS A0A2I3RFV3_PANTR/966-1013   AC A0A2I3RFV3.1
#=GS A0A151NYQ1_ALLMI/916-962    AC A0A151NYQ1.1
#=GS A0A3Q7ULR7_URSAR/939-986    AC A0A3Q7ULR7.1
#=GS H3DDJ6_TETNG/558-602        AC H3DDJ6.1
#=GS A0A3B5AB77_9TELE/687-731    AC A0A3B5AB77.1
#=GS A0A3B3IGG7_ORYLA/950-996    AC A0A3B3IGG7.1
#=GS A0A093PCU5_9PASS/892-938    AC A0A093PCU5.1
#=GS A0A2K5CFZ2_AOTNA/860-907    AC A0A2K5CFZ2.1
#=GS H3C1B3_TETNG/587-631        AC H3C1B3.1
#=GS A0A1S3R4V3_SALSA/928-975    AC A0A1S3R4V3.1
#=GS A0A060YF71_ONCMY/430-471    AC A0A060YF71.1
#=GS A0A3Q7UA15_URSAR/927-974    AC A0A3Q7UA15.1
#=GS F7F370_MONDO/941-988        AC F7F370.2
#=GS A0A3P8YRK4_ESOLU/936-980    AC A0A3P8YRK4.1
#=GS A0A3B4UDI8_SERDU/931-977    AC A0A3B4UDI8.1
#=GS A0A383Z1V8_BALAS/902-948    AC A0A383Z1V8.2
#=GS A0A151NZN6_ALLMI/897-943    AC A0A151NZN6.1
#=GS A0A1S3GLS9_DIPOR/696-743    AC A0A1S3GLS9.1
#=GS G5B7J0_HETGA/906-953        AC G5B7J0.1
#=GS A0A3Q7TLH5_URSAR/927-973    AC A0A3Q7TLH5.1
#=GS H0WLU7_OTOGA/924-971        AC H0WLU7.1
#=GS A0A218UAG7_9PASE/905-951    AC A0A218UAG7.1
#=GS A0A3B5A737_9TELE/931-977    AC A0A3B5A737.1
#=GS H2MWH4_ORYLA/940-984        AC H2MWH4.2
#=GS A0A2K6QQB8_RHIRO/902-949    AC A0A2K6QQB8.1
#=GS A0A3P8YTF3_ESOLU/933-977    AC A0A3P8YTF3.1
#=GS A0A2K5Q5C5_CEBCA/898-945    AC A0A2K5Q5C5.1
#=GS A0A087RB90_APTFO/900-946    AC A0A087RB90.1
#=GS A0A096M0W0_POEFO/938-979    AC A0A096M0W0.1
#=GS A0A3Q3XCQ3_MOLML/880-916    AC A0A3Q3XCQ3.1
#=GS G1U0V9_RABIT/891-937        AC G1U0V9.2
#=GS A0A2K5CFX9_AOTNA/854-901    AC A0A2K5CFX9.1
#=GS G1LNQ5_AILME/921-968        AC G1LNQ5.1
#=GS A0A340XGU4_LIPVE/940-987    AC A0A340XGU4.1
#=GS A0A1U7UTP0_TARSY/891-938    AC A0A1U7UTP0.1
#=GS A0A2K6LLE0_RHIBE/929-976    AC A0A2K6LLE0.1
#=GS F6RLJ3_HORSE/940-987        AC F6RLJ3.2
#=GS A0A2K5WLC0_MACFA/928-975    AC A0A2K5WLC0.1
#=GS K7F278_PELSI/896-942        AC K7F278.1
#=GS A0A3Q3XCQ8_MOLML/901-942    AC A0A3Q3XCQ8.1
#=GS F1SCL0_PIG/940-987          AC F1SCL0.3
#=GS A0A2I0LPD9_COLLI/909-955    AC A0A2I0LPD9.1
#=GS A0A060YED5_ONCMY/590-637    AC A0A060YED5.1
#=GS H3DBQ6_TETNG/575-621        AC H3DBQ6.1
#=GS G1N117_MELGA/892-938        AC G1N117.1
#=GS A0A2I2UE37_FELCA/939-986    AC A0A2I2UE37.2
#=GS A0A3P9A185_ESOLU/928-975    AC A0A3P9A185.1
#=GS A0A2K5K0V8_COLAP/934-981    AC A0A2K5K0V8.1
#=GS A0A3Q7VGR2_URSAR/915-962    AC A0A3Q7VGR2.1
#=GS A0A1D5P6T3_CHICK/888-934    AC A0A1D5P6T3.2
#=GS A0A096M5E1_POEFO/923-969    AC A0A096M5E1.1
#=GS A0A091V3R3_OPIHO/901-947    AC A0A091V3R3.1
#=GS I3LXY7_ICTTR/917-964        AC I3LXY7.2
#=GS A0A2U4B421_TURTR/685-732    AC A0A2U4B421.1
#=GS INSR_HUMAN/940-987          AC P06213.4
#=GS INSR_HUMAN/940-987          DR PDB; 6HN4 F; 882-888;
#=GS INSR_HUMAN/940-987          DR PDB; 6PXV A; 901-910;
#=GS INSR_HUMAN/940-987          DR PDB; 6SOF B; 901-917;
#=GS INSR_HUMAN/940-987          DR PDB; 6PXV C; 901-910;
#=GS INSR_HUMAN/940-987          DR PDB; 2MFR A; 2-49;
#=GS INSR_HUMAN/940-987          DR PDB; 4ZXB E; 901-910;
#=GS INSR_HUMAN/940-987          DR PDB; 6HN4 E; 882-888;
#=GS INSR_HUMAN/940-987          DR PDB; 6SOF D; 901-917;
#=GS A0A3Q3EM76_9LABR/927-973    AC A0A3Q3EM76.1
#=GS A0A2D0RTI5_ICTPU/915-958    AC A0A2D0RTI5.1
#=GS A0A091CWD8_FUKDA/1022-1069  AC A0A091CWD8.1
#=GS A0A3P8RPH4_AMPPE/934-978    AC A0A3P8RPH4.1
#=GS A0A3Q3XF24_MOLML/910-956    AC A0A3Q3XF24.1
#=GS A0A2R9A3A9_PANPA/891-938    AC A0A2R9A3A9.1
#=GS A0A3B3R6G5_9TELE/925-972    AC A0A3B3R6G5.1
#=GS H2U2F3_TAKRU/932-976        AC H2U2F3.2
#=GS F1LPL6_RAT/941-988          AC F1LPL6.3
#=GS A0A1D5QCC6_MACMU/695-742    AC A0A1D5QCC6.1
#=GS INSR_RAT/941-988            AC P15127.1
#=GS A0A091WTM8_NIPNI/902-948    AC A0A091WTM8.1
#=GS A0A3Q3X8C6_MOLML/904-944    AC A0A3Q3X8C6.1
#=GS A0A3P8YA87_ESOLU/915-947    AC A0A3P8YA87.1
#=GS A0A3B3VRB6_9TELE/916-962    AC A0A3B3VRB6.1
#=GS A0A2I4AKQ2_9TELE/932-976    AC A0A2I4AKQ2.1
#=GS A0A3B3R6N2_9TELE/925-972    AC A0A3B3R6N2.1
#=GS B7ZS80_XENLA/937-981        AC B7ZS80.1
#=GS A0A2Y9L682_ENHLU/927-974    AC A0A2Y9L682.1
#=GS A0A2K5WLC5_MACFA/940-987    AC A0A2K5WLC5.1
#=GS A0A093GT55_STRCA/892-938    AC A0A093GT55.1
#=GS G3RQJ8_GORGO/905-952        AC G3RQJ8.2
#=GS A0A452RT74_URSAM/562-609    AC A0A452RT74.1
#=GS A0A2Y9LD18_ENHLU/829-876    AC A0A2Y9LD18.1
#=GS A0A3Q1JFL5_ANATE/933-979    AC A0A3Q1JFL5.1
#=GS F1MV64_BOVIN/945-992        AC F1MV64.3
#=GS A0A2I3SGW4_PANTR/937-984    AC A0A2I3SGW4.1
#=GS A0A3Q7V2J0_URSAR/939-985    AC A0A3Q7V2J0.1
#=GS A0A452EKQ6_CAPHI/923-970    AC A0A452EKQ6.1
#=GS A0A0A0MW58_PAPAN/940-987    AC A0A0A0MW58.2
#=GS A0A1S3M1T9_SALSA/590-636    AC A0A1S3M1T9.1
#=GS M3VZL0_FELCA/927-974        AC M3VZL0.3
#=GS A0A3P8W8C7_CYNSE/932-978    AC A0A3P8W8C7.1
#=GS A0A3Q3L0K8_9TELE/931-977    AC A0A3Q3L0K8.1
#=GS A0A2U3YFI6_LEPWE/642-689    AC A0A2U3YFI6.1
#=GS A0A384D9G9_URSMA/950-997    AC A0A384D9G9.1
#=GS A0A3Q2VJY3_HAPBU/929-975    AC A0A3Q2VJY3.1
#=GS A0A2Y9LSN6_DELLE/950-997    AC A0A2Y9LSN6.1
#=GS A0A3P9PDX6_POERE/755-801    AC A0A3P9PDX6.1
#=GS F1SCK8_PIG/928-975          AC F1SCK8.3
#=GS W5NQ38_SHEEP/940-987        AC W5NQ38.1
#=GS A0A3B3C0D0_ORYME/924-970    AC A0A3B3C0D0.1
#=GS A0A402FJU2_9SAUR/917-963    AC A0A402FJU2.1
#=GS A0A151NYL9_ALLMI/903-949    AC A0A151NYL9.1
#=GS A0A2K5Q557_CEBCA/910-957    AC A0A2K5Q557.1
#=GS A0A3B5A912_9TELE/906-948    AC A0A3B5A912.1
#=GS G1QHU4_NOMLE/828-875        AC G1QHU4.3
#=GS A0A3Q2UZL8_HAPBU/940-984    AC A0A3Q2UZL8.1
#=GS A0A3B3SIB8_9TELE/968-1006   AC A0A3B3SIB8.1
#=GS A0A2D0RCA4_ICTPU/917-964    AC A0A2D0RCA4.1
#=GS A0A1S3WNJ7_ERIEU/890-937    AC A0A1S3WNJ7.1
#=GS U3J3T4_ANAPP/916-952        AC U3J3T4.2
#=GS A0A3Q3XF27_MOLML/903-949    AC A0A3Q3XF27.1
#=GS A0A3B3SGT0_9TELE/920-967    AC A0A3B3SGT0.1
#=GS A0A1S3P952_SALSA/741-785    AC A0A1S3P952.1
#=GS W5M9K1_LEPOC/921-967        AC W5M9K1.1
#=GS A0A2K6T1F3_SAIBB/928-975    AC A0A2K6T1F3.1
#=GS H2T2E6_TAKRU/898-944        AC H2T2E6.2
#=GS A0A3P8U1S6_AMPPE/927-973    AC A0A3P8U1S6.1
#=GS A0A0P7UEY6_SCLFO/1153-1199  AC A0A0P7UEY6.1
#=GS A0A340XMY7_LIPVE/928-975    AC A0A340XMY7.1
#=GS F6YX75_MACMU/98-145         AC F6YX75.2
#=GS A0A2K6LLA2_RHIBE/930-977    AC A0A2K6LLA2.1
#=GS A0A4D9E8P2_9SAUR/918-964    AC A0A4D9E8P2.1
#=GS G3PXN2_GASAC/934-980        AC G3PXN2.1
#=GS A0A2K5K0T8_COLAP/946-993    AC A0A2K5K0T8.1
#=GS I3KQM7_ORENI/933-979        AC I3KQM7.1
#=GS A0A3Q1JA87_ANATE/933-979    AC A0A3Q1JA87.1
#=GS A0A3Q4MNE0_NEOBR/929-975    AC A0A3Q4MNE0.1
#=GS F6SXU2_ORNAN/461-508        AC F6SXU2.2
G3T361_LOXAF/914-961                   .....THFYVTDyLDVPSNIAKIIIGPLIFVFLVSVVIGS..IYLFLRKRQPDGP...
A0A3B3BZV3_ORYME/942-986               ....i-YFFMPH.-SNP-GLVWIVSGPVICFILLLFVGAG..VFVVIKKRQTEGP...
A0A3Q1BU58_AMPOC/854-897               .....TYFFMPN.-----RLIWIVIGPVICFILLLFFSVSekGSLLFCCRQTEGP...
A0A226MM59_CALSU/717-763               .....TYFYVAD.YLNAQPNIAVIIVPIIFAIIIAGIIGA..AYVLVKKRQTEGP...
A0A2Y9R3E1_TRIMA/614-661               .....THFYVTDyLDVPSNIAKIIIGPLIFVFLISVVIGS..IYLFLRKRHPDGP...
A0A3M0K186_HIRRU/1266-1312             .....TYFYVAD.YLNAQPNIAVIIVPIIFAIIIAGIIGA..AYVLVKKRQTEGP...
G3W0M2_SARHA/94-140                    .....TYFYVAD.YYVPSNIAKIVIGPVIIIIFLISVVVV..LYVVVKKRQTEGP...
H2NX99_PONAB/889-936                   .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A3Q2WEL1_HAPBU/935-979               ....i-YFFMPN.-PDQ-GLIWIVMGPVICFILLLLAGGG..AFVYFKKRQTEGP...
A0A091GU13_9AVES/892-938               .....TYFYVAD.YLNAQPNIAVIIVPIIFAIIIAGIIGA..AYVLVKKRQTEGP...
A0A3Q4BY16_MOLML/910-956               .....TYFYVQD.PSDPLYLVKIVIGPVICFFLLLFVALA..GFVLFKKNQTLGP...
A0A3P8W3R3_CYNSE/937-981               .....TYFFMPN.-PDP-GLVWIVIGPVFCFILLLFVGGG..VFWILKKKQSEGP...
A0A3Q3L1Q2_9TELE/904-948               .....TYFFMPN.-PDP-GLIWIVIGPVICFILLLFVGGG..VFLFYKKRQTEGP...
A0A060XKT4_ONCMY/210-254               .....TFFFMPD.-KDT-TSLKIIIGSVICFILLLFVGGG..VFMIFKKKQTEGP...
A0A3B4BWB3_PYGNA/853-899               .thvl----LPScPSDY-MNVKIIIGPVILLIILLFIGAG..AFVVFRKKQTEGP...
A0A3P9A2V0_ESOLU/865-912               .....THFYVQDlRVDPSNLVKIIIGPVIFIVLLIVVASG..VFVVLKKKQTQGP...
A0A3Q3BJC8_KRYMA/932-976               ....v-YFFMPN.-SDP-GLVWIVIGPVICFVLLLIAASG..VFYIIRKKQIEGP...
A0A0A0MW86_PAPAN/907-954               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSIVIGS..IYLFLRKRQPDGP...
A0A3Q3EMI1_9LABR/869-915               .....TYFYVQD.ASDPLYFVKIIIGPILCFVLVLCMATA..GFVIFRKSQTQGP...
A0A3Q1DGV6_AMPOC/931-977               .....TYFYVQD.ASDPLYIVKIVIGPIICFVLLLFVAVA..GFIMFKKNQTQGP...
A0A455B2W6_PHYMC/71-118                .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A3B1J7U9_ASTMX/922-969               .....THFYVQDlRVDPSNMLKIVIAPVICIFLLLLMGLA..GFIVFKKKQTEGP...
J9NY09_CANLF/902-949                   .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A3Q3X5C5_MOLML/924-970               ....s-YFFMPN.RKAGGRLIWIVIGPVICFILLLFVGGG..VFLIFKKKQKEGP...
A0A2U3WSM4_ODORO/939-986               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A2K6T1C8_SAIBB/940-987               .....TYFYVSDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYIFLRKRQQDGP...
A0A3B5PVH2_XIPMA/900-946               ....s-YFYVQD.PSDPLSIVKIIIGPIICFVLLIFLGVA..GFVVFRKNQTQGP...
A0A099Z5W3_TINGU/904-950               ....a-YFYVAD.YLNAQPNIAVIIVPIIFAIILAGIIGA..AYVLVKKRQTEGP...
G1PNP3_MYOLU/899-945                   .....TYFYVTN.YYVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQSDGP...
L5KC78_PTEAL/772-819                   .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A3Q4HDN3_NEOBR/856-897               ....i-YFFMPN.-----RLIWIVMGPVICFILLLLAGGG..AFVYFKKRQTEGP...
A0A151NYD6_ALLMI/904-950               .....TYFYVAD.YLNAQPNIAVIVVPIIFASIIIGAIGI..VYVLVKKRQTEGP...
A0A3B4FJD9_9CICH/929-975               .....TYFYVED.PSDPLHVVKIIIGPVICFVLVLFVALV..GFVMFKKSQTQGP...
A0A452IPX3_9SAUR/889-935               ....s-YFYVAD.YLNPQSNIAVVVVPIIFCIIIAGIIGA..AYVFVKKRQTEGP...
A0A1U8DJE2_ALLSI/899-945               .....TYFYVAD.YLNAQPNIAVIVVPIIFASIIIGAIGI..VYVLVKKRQTEGP...
A0A455B503_PHYMC/71-117                .....TYFYVTD.YYVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A091J0U9_EGRGA/902-948               .....TYFYVAD.YLNAQPNIAVIIVPIIFAIIIAGIIGA..AYVLVKKRQTEGP...
T2CB11_RAT/942-989                     .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A3Q2ECP6_CYPVA/925-971               ....s-YFYVQD.PSDPLYIVKIIIGPIICIVLLLFVAVA..GFIVFKKNQTQGP...
A0A3P8TX69_AMPPE/927-970               .....TYFYVQD.ASDPLYIVKIVIGPIICFVLLLFVAVA..GFIMFKKK-----ya.
A0A2K5L4E5_CERAT/897-944               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSIVIGS..IYLFLRKRQPDGP...
H2QF61_PANTR/949-996                   .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
U3KHF2_FICAL/887-933                   .....TYFYVAD.YLNAQPNIAVIIVPIIFAIIIAGIIGA..AYVLVKKRQTEGP...
F1QNX5_DANRE/917-963                   .....THFYVQDlRVDPSNVLKIVIGPVICFFLLLLLCVG..-FYIVKKKQTEGP...
A0A3B4T7Q3_SERDU/935-979               .....TYFFMPN.-PDP-GLIWIVIGPVICFILLLFVGGG..VFWIFKKRQTEGP...
A0A3P8PHL2_ASTCA/929-975               .....TYFYVED.PSDPLHVVKIVIGPVICFVLVLFVALV..GFVMFKKSQTQGP...
W5M9H7_LEPOC/929-975                   .....TYFYVQD.PRDPSSVMKIAIGSVICIVLILVVAGA..VFMVVRKKQTEGP...
A0A2K6T1L4_SAIBB/946-993               .....TYFYVSDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYIFLRKRQQDGP...
A0A2K5YPC1_MANLE/859-906               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSIVIGS..IYLFLRKRQPDGP...
A0A2I3NG96_PAPAN/932-979               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSIVIGS..IYLFLRKRQPDGP...
A0A3Q1MJC8_BOVIN/921-968               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..ICLFLRKRQPDGP...
A0A2K6B0Q0_MACNE/864-911               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSIVIGS..IYLFLRKRQPDGP...
F6R9D2_HORSE/928-975                   .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A3P9DDV5_9CICH/929-975               .....TYFYVED.PSDPLHVVKIVIGPVICFVLVLFVALV..GFVMFKKSQTQGP...
A0A3Q2DGV9_CYPVA/931-975               .....TYFFMPS.-PDT-GLVWIVSGPVICSILLLFVGGA..VFFIIRKRQTEGP...
A0A091F769_CORBR/905-951               .....TYFYVAD.YLNAQPNIAVIIVPIIFAIIIAGIIGA..AYVLVKKRQTEGP...
A0A3Q3L1B4_9TELE/896-942               .....TYFFVQD.ASDPLYIVKIIIGPVICLVLLLCVAAA..GFVMFKKNQTQGP...
K7CJP0_PANTR/940-987                   .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A498NEN4_LABRO/979-1022              ....a-YFFVQD.-RDM--NMKIIIGPLICFIVLLFLAST..VFIVLRKKQTEGP...
A0A0Q3Q2Q0_AMAAE/888-934               .....TYFYVAD.YLNAQPNIAVIIVPIIFAIIIAGIIGA..AYVLVKKRQTEGP...
A0A3P8QPT8_ASTCA/970-1010              svaad-------.----QGLIWIVMGPVICFILLLLAGGG..AFVYFKKRQTEGP...
A0A452EK73_CAPHI/911-958               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..ICLFLRKRQPDGP...
A0A0P7UK52_SCLFO/708-753               .....TYFYVPD.RTDR-NLMKIVIGPVVCLILLLLVGAG..VFVMFKKKQIEGP...
U3FCC1_CALJA/940-987                   .....TYFYVSDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYIFLRKRQQDGP...
A0A2U9C2U4_SCOMX/935-979               .....TYFFMPN.-PDP-GLIWIVIGPVICFILLLFVGGG..VFWIFKKKQTEGP...
A0A3Q3X596_MOLML/891-931               ....s-YFFMPN.-PDP-GLIWIVIGPVICFILLLFMLSV..V----VYRQKEGP...
A0A3Q1MJG0_BOVIN/902-949               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..ICLFLRKRQPDGP...
A0A2U3WSD9_ODORO/927-974               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A1V4KQM4_PATFA/887-933               .....TYFYVAD.YLNAQPNIAVIIVPIIFAIIIAGIIGA..AYVLVKKRQTEGP...
A0A3Q0H314_ALLSI/916-962               .....TYFYVAD.YLNAQPNIAVIVVPIIFASIIIGAIGI..VYVLVKKRQTEGP...
A0A2R8ZZ37_PANPA/900-947               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A1U7US90_TARSY/903-950               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
U3CV09_CALJA/928-975                   .....TYFYVSDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYIFLRKRQQDGP...
G3P8C9_GASAC/931-975                   .....TYFYMPN.-SDP-GLIWIVMGPVICFILLLFIGGG..VFVILKKRQTEGP...
A0A3B4FIM7_9CICH/871-912               ....i-YFFMPN.-----RLIWIVMGPVICFILLLLAGGG..AFVYFKKRQTEGP...
A0A3P8QRD1_ASTCA/935-979               ....i-YFFMPN.-PDQ-GLIWIVMGPVICFILLLLAGGG..AFVYFKKRQTEGP...
A0A2K6LLA6_RHIBE/929-976               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A3L8RYA5_CHLGU/606-652               .....TYFYVAD.YLNAQPNIAVIIVPIIFAIIIAAIIGA..AYVLVKKRQTEGP...
A0A452RT86_URSAM/630-677               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A287D4G1_ICTTR/893-940               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
G3UEM7_LOXAF/929-976                   .....THFYVTDyLDVPSNIAKIIIGPLIFVFLVSVVIGS..IYLFLRKRQPDGP...
A0A3Q1HVV1_ANATE/907-951               ....m-YFFMPN.-PDP-GLIWIVTGPVICFILLLFVGGG..IFWILKKRQTEGP...
H0YQ96_TAEGU/904-950                   .....TYFYVAD.YLNAQPNIAVIIVPIIFAIIIAAIIGA..AYVLVKKRQTEGP...
A0A1S3WNI0_ERIEU/890-936               .....TYFYVTD.YHVPSNIAKIIIGPLIFVFLFSAVIGS..IYLFLKKRQPDGP...
A0A3Q3X8D1_MOLML/919-959               .....TYFYVQD.---P---MKIVIGPVICFFLLLFVALA..GFVLFKKNQTLGP...
A0A3Q3BJS4_KRYMA/917-963               .....TYFYVQD.PSDPLYIVKIIIGPIICLVLLLIVSVT..GFVLFRKNQTQGP...
A0A2K5YPE3_MANLE/847-894               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSIVIGS..IYLFLRKRQPDGP...
A0A3B5A4N8_9TELE/688-729               .....TYFFMPN.-PDP-GLVWIVIGPVICFILSHFNTAD..VFC---SRQTEGP...
A0A452RTB6_URSAM/618-665               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
F7HRK0_CALJA/931-978                   .....TYFYVSDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYIFLRKRQQDGP...
A0A2Y9L836_ENHLU/939-986               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A3L8RZM3_CHLGU/606-652               .....TYFYVAD.YLNAQPNIAVIIVPIIFAIIIAAIIGA..AYVLVKKRQTEGP...
A0A3P9DTK9_9CICH/935-979               ....i-YFFMPN.-PDQ-GLIWIVMGPVICFILLLLAGGG..AFVYFKKRQTEGP...
A0A498NNJ9_LABRO/918-965               .....THFFVEDlRRDPSNILKIAIGPAICGFLLLVMGGV..GFFLFKKKQTEGP...
I3J076_ORENI/935-979                   ....i-YFFMPN.-PDQ-GLIWIVMGPVICFILLLLAGGG..VFVYFKKRQTEGP...
G1QHT7_NOMLE/830-877                   .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A2K5K0Z5_COLAP/907-954               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
M3YAM5_MUSPF/910-957                   .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
H2U2E9_TAKRU/932-976                   .....TYFFMPS.-PDP-GLIWIVMGPVICFILLLCLGIG..VFVIFKKKQTEGP...
INSR_MOUSE/930-977                     .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A3B3Z515_9TELE/922-966               .....TYFFMPS.-PDS-GIAWIVSAPIVSSILLLFVGVI..AFFAFKKRQTEGP...
A0A2K6QQB2_RHIRO/928-975               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
F6TEA3_XENTR/892-936                   ....a-YFQVPD.HP-HSSIVKIVTGPVIAVILLLFVLVY..-CVIQKKKDAEGP...
R0KN44_ANAPL/892-938                   .....TYFYVAD.YLNAQPNIAVIIVPIIFAIIIAGIIGA..AYVLVKKRQTEGP...
Q1LVG4_DANRE/915-958                   ....a-YFYVQD.REMS---MKIVIILAICIFLLVILASV..GYFVLKKKQTEGP...
A0A0D9R902_CHLSB/943-990               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSIVIGS..IYLFLRKRQPDGP...
A0A1S3P971_SALSA/924-968               .....TFFFMPD.-KDT-TSLKIIIGSVICFILLLFIGGG..VFMIFKKKQTEGP...
G3RCY5_GORGO/893-940                   .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A3B3YNW5_9TELE/916-962               ....s-YFYVQD.PNDPLSIVKIIIGPIVCFVLLVFLGVA..GFVVFRKNQTQGP...
A0A3Q0H234_ALLSI/764-810               .....TYFYVAD.YLNAQPNIAVIVVPIIFASIIIGAIGI..VYVLVKKRQTEGP...
A0A3B4XQ05_SERLL/931-977               .....TYFYVQD.ASDPLYVVKIVIGPVICFVLLLFVAVT..GFVMFKKNQTQGP...
F6S8L3_MACMU/707-754                   .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSIVIGS..IYLFLRKRQPDGP...
A0A3Q3X8C2_MOLML/934-980               .....TYFYVQD.PSDPLYLVKIVIGPVICFFLLLFVALA..GFVLFKKNQTLGP...
A0A3Q1JA29_ANATE/938-982               ....m-YFFMPN.-PDP-GLIWIVTGPVICFILLLFVGGG..IFWILKKRQTEGP...
A0A2K6QQC1_RHIRO/891-938               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
H3A6S8_LATCH/402-448                   ....s-YFHVPH.YTNPSNILKIIIGPVICAIFILGVIGV..VFLIVRKRQTEGP...
A0A3Q1ECC2_9TELE/886-927               .....TYFFMPN.-----RLIWIVIGPVVCFILLLFVAGG..VFVIFKKRQTEGP...
A0A2I4B558_9TELE/928-974               .....TFFYVQD.PSDPLYIVKIIIGPIICVILLVLVSGT..GFILFSKSQTQGP...
A0A2U9BIC6_SCOMX/922-968               .....TYFYVQD.ASDPLYIVKIVIGPIICLVLLLFVAVA..GFVMFKKNQTQGP...
M4AW90_XIPMA/922-966                   .....TYFFMPS.-PDT-GIALIVSAPIVSSILLLFVGVI..AFYVFKKRQTEGP...
E2RPM8_CANLF/931-978                   .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A0A0A3W1_CHAVO/902-948               .....TYFYVAD.YLNAQPNIAVIIVPIIFAIIIAGIIGA..AYVLVKKRQTEGP...
F7EVG8_ORNAN/718-764                   .....TYFYVAD.YYVPSNIAKIIIGPVIFAIFVVGMIGA..IYVFVKKRQTEGP...
A0A2R9A069_PANPA/920-967               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
K7F279_PELSI/608-654                   .....TYFYMAD.YLNPQSNLAVVIVPVVFSIIIAGIIGA..TYVFVKKRQTEGP...
A0A3B4ALX4_9GOBI/878-923               .....TYFYVPD.-SDPMSIVKIAVAPVICFALLLIVAIG..GFVVFRKNQTQGP...
A0A2Y9L5F9_ENHLU/927-973               .....TYFYVTD.YYVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A087XET4_POEFO/916-962               ....s-YFYVQD.PNDPLSIVKIIIGPIVCFVLLVFLGVA..GFVVFRKNQTQGP...
A0A087Y256_POEFO/922-966               .....TYFFMPS.-PDS-GIAWIVSAPIVSSILLLFVGVI..AFFAFKKRQTEGP...
H0VMQ0_CAVPO/929-976                   .....TYFYVTNySDVSSNIAKMIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
W5NQ40_SHEEP/911-958                   .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..ICLFLRKRQPDGP...
A0A226NZW7_COLVI/738-784               .....TYFYVAD.YLNAQPNIAVIIVPIIFAIIIAGIIGA..AYVLVKKRQTEGP...
A0A1S3KK98_SALSA/762-806               .....TYFFMPD.-KDI-VSLNIIIGPVICFILLLFVGGG..VLMVYKKKQIEGP...
A0A3Q7R5Q5_VULVU/1038-1085             .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A2I3RFV3_PANTR/966-1013              .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A151NYQ1_ALLMI/916-962               .....TYFYVAD.YLNAQPNIAVIVVPIIFASIIIGAIGI..VYVLVKKRQTEGP...
A0A3Q7ULR7_URSAR/939-986               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
H3DDJ6_TETNG/558-602                   .....THFFVPN.-PDP-GLVWIVMGPIICFILLLFVGVG..VFVVFKKKQTEGP...
A0A3B5AB77_9TELE/687-731               .....TYFFMPN.-PDP-GLVWIVIGPVICFILLLFVAGG..VFVIFKKRQTEGP...
A0A3B3IGG7_ORYLA/950-996               ....s-FFYVQD.LSDPLYVVKIIIGPIICFVLLLLVSVA..GFVVFKKNQTQGP...
A0A093PCU5_9PASS/892-938               .....TYFYVAD.YLNSQPNIAVIIVPIIFAIIIAGIIGA..AYVLVKKRQTEGP...
A0A2K5CFZ2_AOTNA/860-907               .....TYFYVSDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYIFLRKRQQDGP...
H3C1B3_TETNG/587-631                   .....THFFVPN.-PDP-GLVWIVMGPIICFILLLFVGVG..VFVVFKKKQTEGP...
A0A1S3R4V3_SALSA/928-975               .....THFYVEDlRVDPSNMLKIIIGSVIFIVLLILMTAG..GFVMFKKKQTQGP...
A0A060YF71_ONCMY/430-471               .....THFYVQDlRVDP-SNLLIIIGPVIFIVLLILVAAG..GFVMFRKK-----...
A0A3Q7UA15_URSAR/927-974               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
F7F370_MONDO/941-988                   .....TYFYVADyLDVPSNIAKIIIGPVIIAIFLVSMVGA..IYVFVKKRQTEGP...
A0A3P8YRK4_ESOLU/936-980               .....TFFYMPD.-KDN-NSLKIIIGPVICFILLLVVGSA..VFLFLKKKQTEGP...
A0A3B4UDI8_SERDU/931-977               .....TYFYVQD.ASDPLYVVKIVIGPVICFVLLLFVAVT..GFVMFKKNQTQGP...
A0A383Z1V8_BALAS/902-948               .....TYFYVTD.YYVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A151NZN6_ALLMI/897-943               .....TYFYVAD.YLNAQPNIAVIVVPIIFASIIIGAIGI..VYVLVKKRQTEGP...
A0A1S3GLS9_DIPOR/696-743               .....TYFYVTDyLDVPSNLAKIIIGPLIFVFLFSGVIGS..IYLFLRKRQPDGP...
G5B7J0_HETGA/906-953                   .....TYFYVTNySDVSSNIAKMIIGPLIFVFLFSIVIGS..IYLFLRKRQPDGP...
A0A3Q7TLH5_URSAR/927-973               .....TYFYVTD.YYVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
H0WLU7_OTOGA/924-971                   .....THFYMTDyLDVPSNIAKIIIGPLIFVFLFSIVIGS..IYIFLRKRQPDGP...
A0A218UAG7_9PASE/905-951               .....TYFYVAD.YLNAQPNIAVIIVPIIFAIIIAAIIGA..AYVLVKKRQTEGP...
A0A3B5A737_9TELE/931-977               .....TYFYVQD.ASDPLYIVKIVIGPIICFVLLLFVAVA..GFVMFKKNQTQGP...
H2MWH4_ORYLA/940-984                   ....i-YFFMPH.-SNP-GLVWIVSGPVICFILLLFVGAG..VFVVIKKRQIEGP...
A0A2K6QQB8_RHIRO/902-949               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A3P8YTF3_ESOLU/933-977               .....TFFYMPD.-KDN-NSLKIIIGPVICFILLLVVGSA..VFLFLKKKQTEGP...
A0A2K5Q5C5_CEBCA/898-945               .....TYFYVSDyLDVPSNIAKIIIGPLIFVFLFSAVIGS..IYIFLRKRQQDGP...
A0A087RB90_APTFO/900-946               .....TYFYVAD.YLNAQPNIAVIIVPIIFAIIIAGIIGA..AYVLVKKRQTEGP...
A0A096M0W0_POEFO/938-979               .....TYFFMPS.-----RIAWIVSAPIVSSILLLFVGVI..AFFAFKKRQTEGP...
A0A3Q3XCQ3_MOLML/880-916               ....s-YFFMPN.RK----------AGVICFILLLFVGGG..VFLIFKKKQKEGP...
G1U0V9_RABIT/891-937                   .....TYFYVTD.YHVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A2K5CFX9_AOTNA/854-901               .....TYFYVSDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYIFLRKRQQDGP...
G1LNQ5_AILME/921-968                   .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A340XGU4_LIPVE/940-987               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A1U7UTP0_TARSY/891-938               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A2K6LLE0_RHIBE/929-976               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
F6RLJ3_HORSE/940-987                   .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A2K5WLC0_MACFA/928-975               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSIVIGS..IYLFLRKRQPDGP...
K7F278_PELSI/896-942                   .....TYFYMAD.YLNPQSNLAVVIVPVVFSIIIAGIIGA..TYVFVKKRQTEGP...
A0A3Q3XCQ8_MOLML/901-942               ....s-YFFMPN.-----RLIWIVIGPVICFILLLFVGGG..VFLIFKKKQKEGP...
F1SCL0_PIG/940-987                     .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A2I0LPD9_COLLI/909-955               .....TYFYVAD.YLNAQPNIAVIIVPIIFAIIIAGIIGA..AYVLVKKRQTEGP...
A0A060YED5_ONCMY/590-637               .....THFYVEDlRVDPSNMLKIIIGSVIFIVLLILMTAG..GFLMFKKKQTQGP...
H3DBQ6_TETNG/575-621                   .....TYFYVQD.PSDPLHVVKIVIGPVICSVLLLLVAVG..GFVMFKKNQTQGP...
G1N117_MELGA/892-938                   .....TYFYVAD.YLNAQPNIAVIIVPIIFAIIIAGIIGA..AYVLVKKRQTEGP...
A0A2I2UE37_FELCA/939-986               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A3P9A185_ESOLU/928-975               .....THFYVQDlRVDPSNLVKIIIGPVIFIVLLIVVASG..VFVVLKKKQTQGP...
A0A2K5K0V8_COLAP/934-981               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A3Q7VGR2_URSAR/915-962               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A1D5P6T3_CHICK/888-934               .....TYFYVAD.YLNAQPNIAVIIVPIIFAIIIAGIIGA..AYVLVKKRQTEGP...
A0A096M5E1_POEFO/923-969               ....s-YFYVQD.PNDPLSIVKIIIGPIVCFVLLVFLGVA..GFVVFRKNQTQGP...
A0A091V3R3_OPIHO/901-947               .....TYFYVAD.YLNAQPNIAVIIVPIIFAIIIAGIIGA..AYVLVKKRQTEGP...
I3LXY7_ICTTR/917-964                   .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A2U4B421_TURTR/685-732               .....TYFYVTDyLDMPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
INSR_HUMAN/940-987                     .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
#=GR INSR_HUMAN/940-987          SS    .....EEEEECSSTSSSTCHHHHHHHHHHHHHHHHHHHHH..HHHHHTSSXXXXS...
A0A3Q3EM76_9LABR/927-973               .....TYFYVQD.ASDPLYFVKIIIGPILCFVLVLCMATA..GFVIFRKSQTQGP...
A0A2D0RTI5_ICTPU/915-958               ....v-HFYVPD.NYM---NVKIIIGPVILLIISIFVGSA..VCFVLRKKQTEGP...
A0A091CWD8_FUKDA/1022-1069             .....TYFYVTNySDVSSNIAKMIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A3P8RPH4_AMPPE/934-978               .....TYFFMPN.-PDQ-GLIWIVIGPVICFILLLFVAGG..VFVIFKKRQTAGP...
A0A3Q3XF24_MOLML/910-956               .....TYFYVQD.PSDPLYLVKIVIGPVICFFLLLFVALA..GFVLFKKNQTLGP...
A0A2R9A3A9_PANPA/891-938               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A3B3R6G5_9TELE/925-972               ....g-HFFVQDlRADPFSMVKIVIGPVICIILLLAVATS..GFLVFRKKRTEGP...
H2U2F3_TAKRU/932-976                   .....TYFFMPS.-PDP-GLIWIVMGPVICFILLLCLGIG..VFVIFKKKQTEGP...
F1LPL6_RAT/941-988                     .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A1D5QCC6_MACMU/695-742               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSIVIGS..IYLFLRKRQPDGP...
INSR_RAT/941-988                       .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A091WTM8_NIPNI/902-948               .....TYFYVAD.YLNAQPNIAVIIVPIIFAIIIAGIIGA..AYVLVKKRQTEGP...
A0A3Q3X8C6_MOLML/904-944               .....TYFYVQD.---P---MKIVIGPVICFFLLLFVALA..GFVLFKKNQTLGP...
A0A3P8YA87_ESOLU/915-947               .....THFYVQDlRVDPSNLVKIIIGPVIFIVLYLF----..-------------sl.
A0A3B3VRB6_9TELE/916-962               ....s-YFYVQD.PNDPLSIVKIIIGPIVCFVLLVFLGVA..GFVMFRKNQTQGP...
A0A2I4AKQ2_9TELE/932-976               .....TYFFVPN.-SDA-GLAWIVIGPVICFILLLFVAGG..VFYIIRKRQIEGP...
A0A3B3R6N2_9TELE/925-972               ....g-HFFVQDlRADPFSMVKIVIGPVICIILLLAVATS..GFLVFRKKRTEGP...
B7ZS80_XENLA/937-981                   ....a-YFQVPD.HP-HSNIVKIITGPIIAVFLLLIVLVY..-CVVQKKKDAEGP...
A0A2Y9L682_ENHLU/927-974               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A2K5WLC5_MACFA/940-987               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSIVIGS..IYLFLRKRQPDGP...
A0A093GT55_STRCA/892-938               .....TYFYVAD.YLNAQPNIAVIIVPIIFAIIIAGIIGA..AYVLVKKRQTEGP...
G3RQJ8_GORGO/905-952                   .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A452RT74_URSAM/562-609               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A2Y9LD18_ENHLU/829-876               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A3Q1JFL5_ANATE/933-979               .....TFFYVQD.PTDPLYIVKIIIGPVICFVLLLLVAAT..GFIMFKKNQTQGP...
F1MV64_BOVIN/945-992                   .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..ICLFLRKRQPDGP...
A0A2I3SGW4_PANTR/937-984               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A3Q7V2J0_URSAR/939-985               .....TYFYVTD.YYVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A452EKQ6_CAPHI/923-970               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..ICLFLRKRQPDGP...
A0A0A0MW58_PAPAN/940-987               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSIVIGS..IYLFLRKRQPDGP...
A0A1S3M1T9_SALSA/590-636               .....THFYVQDlRVDP-SNLLIIIGPVIFMVLLILVAAG..GFVMFRKKQTQGP...
M3VZL0_FELCA/927-974                   .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A3P8W8C7_CYNSE/932-978               .....TYFYVQD.TSDPLYIVKIVIAPIICFVLLLLVAAV..GFFMFRKSQTQGP...
A0A3Q3L0K8_9TELE/931-977               .....TYFFVQD.ASDPLYIVKIIIGPVICLVLLLCVAAA..GFVMFKKNQTQGP...
A0A2U3YFI6_LEPWE/642-689               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A384D9G9_URSMA/950-997               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A3Q2VJY3_HAPBU/929-975               .....TYFYVED.PSDPLHVVKIVIGPVICFVLVLFVALV..GFVMFKKSQTQGP...
A0A2Y9LSN6_DELLE/950-997               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A3P9PDX6_POERE/755-801               ....s-YFYVQD.PSDPLSIVKIIIGPIXCVVLLVFLGLA..GFVMFRKNQTQGP...
F1SCK8_PIG/928-975                     .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
W5NQ38_SHEEP/940-987                   .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..ICLFLRKRQPDGP...
A0A3B3C0D0_ORYME/924-970               ....s-FFYVQD.LSDPLYVVKIIIGPIICFVLLLLVSVV..GFVVFKKNQTQGP...
A0A402FJU2_9SAUR/917-963               .....TYFYVSD.YLNTPTNLVGVIVPIIFTFFFIGVIIG..TYIFIRKRQKEGP...
A0A151NYL9_ALLMI/903-949               .....TYFYVAD.YLNAQPNIAVIVVPIIFASIIIGAIGI..VYVLVKKRQTEGP...
A0A2K5Q557_CEBCA/910-957               .....TYFYVSDyLDVPSNIAKIIIGPLIFVFLFSAVIGS..IYIFLRKRQQDGP...
A0A3B5A912_9TELE/906-948               .....TYFYVQD.ASDPLYIVKIVIGPIICFVLLLFVAVA..GFVI----QTQGP...
G1QHU4_NOMLE/828-875                   .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A3Q2UZL8_HAPBU/940-984               ....i-YFFMPN.-PDQ-GLIWIVMGPVICFILLLLAGGG..AFVYFKKRQTEGP...
A0A3B3SIB8_9TELE/968-1006              ....a-YFYVLDrGADPNNVMKIVIGPVICVIMLLLVGLG..V------------qta
A0A2D0RCA4_ICTPU/917-964               ....e-YFYIKDlRVDPSNMIKIIVVPLVCVVLVVLMAMA..GFIMVRKKQAEGP...
A0A1S3WNJ7_ERIEU/890-937               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSAVIGS..IYLFLKKRQPDGP...
U3J3T4_ANAPP/916-952                   .....TYFYVPN.-------IAVIIVPIIFAIIIAGIIGA..AYVLVKKRQ----l..
A0A3Q3XF27_MOLML/903-949               .....TYFYVQD.PSDPLYLVKIVIGPVICFFLLLFVALA..GFVLFKKNQTLGP...
A0A3B3SGT0_9TELE/920-967               ....a-YFYVLDrGADPNNVMKIVIGPVICVIMLLLVGLG..VFVVFKKKQTAGP...
A0A1S3P952_SALSA/741-785               .....TFFFMPD.-KDT-TSLKIIIGSVICFILLLFIGGG..VFMIFKKKQTEGP...
W5M9K1_LEPOC/921-967                   .....TYFYVQD.PRDPSSVMKIAIGSVICIVLILVVAGA..VFMVVRKKQTEGP...
A0A2K6T1F3_SAIBB/928-975               .....TYFYVSDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYIFLRKRQQDGP...
H2T2E6_TAKRU/898-944                   .....TYFYVQD.PSDPLYIVKIIIGPIICFVLLLLVAVG..GFVMFKKSQTQGP...
A0A3P8U1S6_AMPPE/927-973               .....TYFYVQD.ASDPLYIVKIVIGPIICFVLLLFVAVA..GFIMFKKNQTQGP...
A0A0P7UEY6_SCLFO/1153-1199             ....r-HFVVQN.PRDHFSVLKVVIGPVICVVLLLVVATV..GFLMFKKKQTEGP...
A0A340XMY7_LIPVE/928-975               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
F6YX75_MACMU/98-145                    .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSIVIGS..IYLFLRKRQPDGP...
A0A2K6LLA2_RHIBE/930-977               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
A0A4D9E8P2_9SAUR/918-964               .....TYFYVAD.YLNPQSNIAVVVVPIIFCIIIAGIIGA..AYIFVKKRQTEGP...
G3PXN2_GASAC/934-980                   .....TYFFVQD.PSDSLYVLKIIIGPVICFVLLLFVAVA..GFVMFKKNQTQGP...
A0A2K5K0T8_COLAP/946-993               .....TYFYVTDyLDVPSNIAKIIIGPLIFVFLFSVVIGS..IYLFLRKRQPDGP...
I3KQM7_ORENI/933-979                   .....TYFYVED.PSDPLHVVKIVIGPIICFVLVLCVALV..GFVMFKKSQTQGP...
A0A3Q1JA87_ANATE/933-979               .....TFFYVQD.PTDPLYIVKIIIGPVICFVLLLLVAAT..GFIMFKKNQTQGP...
A0A3Q4MNE0_NEOBR/929-975               .....TYFYVED.PSDPLHVVKIVIGPVICFVLVLCVALA..GFVMFKKSQTQGP...
F6SXU2_ORNAN/461-508                   .....TYFYVADyLDVPSNIAKIIIGPVIFAIFVVGMIGA..IYVFVKKRQTEGP...
#=GC SS_cons                           .....EEEEECSSTSSSTCHHHHHHHHHHHHHHHHHHHHH..HHHHHTSSXXXXS...
#=GC seq_cons                          .....TYFYVsD.hssPpslsKIIIGPlIhshLh.hVhGu..lalhl+KRQs-GP...
//
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