GenomeNet

Database: Pfam
Entry: Intimin_C
LinkDB: Intimin_C
Original site: Intimin_C 
#=GF ID   Intimin_C
#=GF AC   PF07979.12
#=GF DE   Intimin C-type lectin domain
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_1879 (Release 16.0)
#=GF GA   21.40 21.40;
#=GF TC   21.40 120.20;
#=GF NC   21.30 20.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Intimin
#=GF RN   [1]
#=GF RM   10835344
#=GF RT   Structural basis for recognition of the translocated intimin
#=GF RT   receptor (Tir) by intimin from enteropathogenic Escherichia
#=GF RT   coli. 
#=GF RA   Batchelor M, Prasannan S, Daniell S, Reece S, Connerton I,
#=GF RA   Bloomberg G, Dougan G, Frankel G, Matthews S; 
#=GF RL   EMBO J 2000;19:2452-2464.
#=GF DR   INTERPRO; IPR013117;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is found at the C-terminus of intimin. Its structure
#=GF CC   has been solved and shown to have a C-lectin type of structure
#=GF CC   [1]. Intimin is a bacterial adhesion molecule involved in
#=GF CC   intimate attachment of enteropathogenic and enterohemorrhagic
#=GF CC   Escherichia coli to mammalian host cells. Intimin targets the
#=GF CC   translocated intimin receptor (Tir), which is exported by the
#=GF CC   bacteria and integrated into the host cell plasma membrane.
#=GF SQ   2
#=GS EAE_ECO57/839-934     AC P43261.2
#=GS EAE_ECO57/839-934     DR PDB; 2ZQK A; 93-188;
#=GS EAE_ECO57/839-934     DR PDB; 2ZWK C; 93-188;
#=GS EAE_ECO57/839-934     DR PDB; 3NCX A; 839-934;
#=GS EAE_ECO57/839-934     DR PDB; 3NCW A; 839-934;
#=GS EAE_ECO57/839-934     DR PDB; 3NCW B; 839-934;
#=GS EAE_ECO57/839-934     DR PDB; 2ZQK B; 93-188;
#=GS EAE_ECO57/839-934     DR PDB; 3NCX B; 839-934;
#=GS EAE_ECO57/839-934     DR PDB; 3NCW C; 839-934;
#=GS EAE_ECO57/839-934     DR PDB; 3NCW D; 839-934;
#=GS EAE_ECO57/839-934     DR PDB; 2ZWK A; 93-188;
#=GS EAE_ECO57/839-934     DR PDB; 2ZWK E; 93-188;
#=GS D2TKE6_CITRI/835-936  AC D2TKE6.1
EAE_ECO57/839-934                PSYM.IKVDK--QAYYADAMSICKNL---LPSTQTVLSDIYDSWGAANKYSHYSSMNSITAWIKQTSSEQRSGVSSTYNLITQNPLPGVNVNTPNVYAVCVE
#=GR EAE_ECO57/839-934     SS    -SEE.EEEEE--E-THHHHHHHTTT----S-SSHHHHHHHHHHH--GGGSTTCTT-S--EEEE---HHHHHTTEEEEEETTTEEEEEEEETT-SS-EEEEEE
D2TKE6_CITRI/835-936             PDNIiIAVDKINRMAYSEAESRCQAISSNLAQSKSVLENIYSKWGAANKYPYYSSSNSLTAWIKQSTSDSASGVSNTYDLVTTNSLTNVKATDKNAFAVCVK
#=GC SS_cons                     -SEE.EEEEE--E-THHHHHHHTTT----S-SSHHHHHHHHHHH--GGGSTTCTT-S--EEEE---HHHHHTTEEEEEETTTEEEEEEEETT-SS-EEEEEE
#=GC seq_cons                    Ps.h.ItVDK..phhYu-A.ShCpsl...LspopoVLpsIYspWGAANKYsaYSS.NSlTAWIKQooS-ptSGVSsTYsLlTpNsLssVpsss.NsaAVCVc
//
DBGET integrated database retrieval system