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Database: Pfam
Entry: IpaB_EvcA
LinkDB: IpaB_EvcA
Original site: IpaB_EvcA 
#=GF ID   IpaB_EvcA
#=GF AC   PF03278.15
#=GF DE   IpaB/EvcA family
#=GF AU   Mifsud W;0000-0002-9805-6461
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_4003 (release 6.5)
#=GF GA   29.90 29.90;
#=GF TC   30.20 45.90;
#=GF NC   25.90 25.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11207575
#=GF RT   Bacterial signals and cell responses during Shigella entry into
#=GF RT   epithelial cells. 
#=GF RA   Tran Van Nhieu G, Bourdet-Sicard R, Dumenil G, Blocker A,
#=GF RA   Sansonetti PJ; 
#=GF RL   Cell Microbiol 2000;2:187-193.
#=GF RN   [2]
#=GF RM   9784578
#=GF RT   Translocated intimin receptors (Tir) of Shiga-toxigenic
#=GF RT   Escherichia coli isolates belonging to serogroups O26, O111, and
#=GF RT   O157 react with sera from patients with hemolytic-uremic
#=GF RT   syndrome and exhibit marked sequence heterogeneity. 
#=GF RA   Paton AW, Manning PA, Woodrow MC, Paton JC; 
#=GF RL   Infect Immun 1998;66:5580-5586.
#=GF DR   INTERPRO; IPR004959;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family includes IpaB, which is an invasion plasmid antigen
#=GF CC   from  Shigella [1], as well as EvcA from E. coli Swiss:Q9ZNF1.
#=GF CC   Members of this family seem to be involved in pathogenicity of
#=GF CC   some enterobacteria. However the exact function of this
#=GF CC   component is not clear.
#=GF SQ   15
#=GS A0A2U8I374_9GAMM/171-318  AC A0A2U8I374.1
#=GS Q8X4Q6_ECO57/39-186       AC Q8X4Q6.1
#=GS Q7DB76_ECO57/44-192       AC Q7DB76.1
#=GS C0B3H5_9GAMM/1-126        AC C0B3H5.1
#=GS Q327H0_SHIDS/34-177       AC Q327H0.1
#=GS A0A653FS40_9CAUD/1-129    AC A0A653FS40.1
#=GS D2TM85_CITRI/35-179       AC D2TM85.1
#=GS Q326S7_SHIDS/44-197       AC Q326S7.1
#=GS IPGB_SHIFL/44-197         AC P33548.1
#=GS Q8X4W3_ECO57/39-185       AC Q8X4W3.1
#=GS D2TKE9_CITRI/43-192       AC D2TKE9.1
#=GS H3RGA5_PANSE/178-329      AC H3RGA5.1
#=GS D2TI21_CITRI/35-184       AC D2TI21.1
#=GS D2TI15_CITRI/33-185       AC D2TI15.1
#=GS Q9AJW7_SHIFL/31-174       AC Q9AJW7.1
#=GS Q9AJW7_SHIFL/31-174       DR PDB; 3LYQ A; 31-174;
#=GS Q9AJW7_SHIFL/31-174       DR PDB; 3LW8 G; 31-174;
#=GS Q9AJW7_SHIFL/31-174       DR PDB; 3LW8 H; 31-174;
#=GS Q9AJW7_SHIFL/31-174       DR PDB; 3LYQ B; 31-174;
#=GS Q9AJW7_SHIFL/31-174       DR PDB; 3LW8 F; 31-174;
#=GS Q9AJW7_SHIFL/31-174       DR PDB; 3LXR F; 31-174;
#=GS Q9AJW7_SHIFL/31-174       DR PDB; 3LWN F; 31-174;
#=GS Q9AJW7_SHIFL/31-174       DR PDB; 3LWN G; 31-174;
#=GS Q9AJW7_SHIFL/31-174       DR PDB; 3LW8 E; 31-174;
A0A2U8I374_9GAMM/171-318             .....gnslrldf----------GTIYKDIMKMIREINPGE.YYKQWLEQEKCTYLCALINLQIDRAFMGH-KQLTKNERLS.LFKETMHY...LnkSDMTIDIACAQGS.IKHLVSTYLMKNTLFTDFLKRI..-.ND.CD...QKSEVNTKISYALSDLMYESIFKEN------------iissvrkt................................
Q8X4Q6_ECO57/39-186                  .............MGERSIRFNVNKFSGCILETVSR-QSTK.DIHGWVSDERTVYPSRVINQEIDNCCLQKNAKISSEERKM.VFSLVSKE...F..-ELTLDVKAAQSS.INHI----IIGNASFGKKMDAL..C.DG.MSr.aVKNSTTDYIANVLADKFYQKHIA--------------pgvdivklrnei............................
Q7DB76_ECO57/44-192                  ........qsnfv-------INHGKLTNQLLQAVAKQTRNG.DTQQWFQQEQTTYISRTVNRTLDDYCRSNNSVISKETKGH.IFRAVENA...L..-QQPLDMNGAQSS.IGHF----LQSNKYFNQKVDEQ..C.GKrVDpitRFNTQTK-MIEQVSQEIFERNFS-GFKVSE-------ikaitqn.................................
C0B3H5_9GAMM/1-126                   ..........mkk-------------------------IDK.DISGWWKDEKKILPSSIINRTIDNLYKRDKVIINKETKQI.LFFLISKK...F..-NLNLDENAAQSTmIQHL--QDIPE---VVKAIDEL..G.--.--...-------------------------------------ssensylkyenycliteyiynflsenkvdfskikeavkei
Q327H0_SHIDS/34-177                  .............MGKRIVKISSTKINTSILSSVSE-QIGE.NITDWKNDEKKVYVSRVVNQCIDKFCAEHSREIGDNLRKQ.IFKQVEKD...Y..-RISLDINAAQSS.INHL----VSGSSYFKKKMDEL..C.EG.MNr.sVKNDTTSNVVNLISDQFFEK------NVQYIDLKKLR........................................
A0A653FS40_9CAUD/1-129               .........mvgk------------------------QCTK.NIDGWIKDERVVYPSRVINQEIDNYCFQKNVKISTEERKR.VFSLVSQE...Y..-ELALDVKAAQSS.INHT----IMGSASFCKKMDAL..S.GG.MSr.nVKNRTSDSIANLLADKFYQKHIDSDVD--I-------vklrnei.................................
D2TM85_CITRI/35-179                  .............MGQRRISFSVQKVSDNILSLVTR-QSTK.DIDGWIKDEQKVYPSRVVNQEIDKFCLENRRNITNNDRKR.VFAIISKH...Y..-GLELDSGAAQSS.INHM----IIGNGSFGKKMDNL..C.EG.MTr.nVKNHTSDYMANLLADKFYEKHIE--------------pdvditrlr...............................
Q326S7_SHIDS/44-197                  .............HKNFGCPVNINKIRDSVIDKIKDSNSGD.QLFCWMSQERTSYVSSMINRSIDEMAIHNGVVLTSDNKKN.IFAAIEKK...F..PDIKLDEKSAQTS.ISHTALNEIASSGLRAKILKRY..S.SD.MD...LFNTQMKDLTNLVSSSVYDKIFNESTKVLQIEISAEV........................................
IPGB_SHIFL/44-197                    ............q-KNFGCPVNINKIRDSVIDKIKDSNSGN.QLFCWMSQERTTYVSSMINRSIDEMAIHNGVVLTSDNKKN.IFAAIEKK...F..PDIKLDEKSAQTS.ISHTALNEIASSGLRAKILKRY..S.SD.MD...LFNTQMKDLTNLVSSSVYDKIFNESTKVLQIEISAEV........................................
Q8X4W3_ECO57/39-185                  ............i-GERTISFSVRKFSGNILETVRR-QSTK.DIDEWIKDERIVYPSRVINQEIDNYCFQKNAKISTEERQR.VFFLVSQE...N..-QLTLDVKAAQSS.INHV----IMGSASFGKKMDAL..C.DG.MSr.dVKNRTSDTIANLLADKFYQKHIDSDI-----------divklrnd................................
D2TKE9_CITRI/43-192                  ........vqsnl------MINHDKLTAQLLKAVAK-QTGNgDTQQWFRQEQITFISKTVNKTVDDYCINNNSTINKETKQH.IFKAVESV...I..-QQPLDINCAQSS.ISHF----LQSNKYFNKIVDEQ..CgKG.VDpitRFNTQTK-MIDDVSCELFEKNFN-STKVSDIK-----aitqs...................................
H3RGA5_PANSE/178-329                 ...........yk--NNNLELDFTVFYDDIFNHITSFNKGD.HFYLWREEEKETYISSIINKEIDNQLSTKKINLSKNYYKDyIFNRLKNElgtY..-NVKLNSKSAQSS.IKHAVLTSLMRNRSFNEFIREN..A.ND.MN...IKNIITTDLVNALSNQIFEDMFID-------------emslprew................................
D2TI21_CITRI/35-184                  ............m-GGRSVSFSTDHMNKQILSTVSR-QSTK.DLLAWKKDEKVIYPSRLVNIGIDKYCAENNTNVTGRVRQR.VFAMISKD...F..-GIKLDARSAQSS.INHI----ITGNGSFGKKTASL..C.EG.MDr.gVKNKAADMLANQLADIFFEKNISQDINIKK-------lqndvkr.................................
D2TI15_CITRI/33-185                  gtrkisfsylrle--------------SELMQCINLKNEG-.KMNEWMREECICFVSRDVNKQLDIFAKNNQTTIPGCVRER.VFQRASFH...C..-GFSLDVRCAQTS.THHM----ILNSLYFQKKMDTLfgS.AD.VE...VRNQCVRTALSSLADIFFER------NVNSIDMNK--frdkvydaivqe............................
Q9AJW7_SHIFL/31-174                  .............MGKRIVKISSTKINTSILSSVSE-QIGE.NITDWKNDEKKVYVSRVVNQCIDKFCAEHSRKIGDNLRKQ.IFKQVEKD...Y..-RISLDINAAQSS.INHL----VSGSSYFKKKMDEL..C.EG.MNr.sVKNDTTSNVANLISDQFFEK------NVQYIDLKKLR........................................
#=GR Q9AJW7_SHIFL/31-174       SS    .............ETTEEEEEEHHHHHHHHHHHHHH-HCSS.THHHHHHHHHHHHHHHHHHHHHHHHHHHTT----HHHHHH.HHHHHHHH...H..-T----TT----H.HHHH----HHT-HHHHHHHHHH..T.TT.B-H.HHHHHHHHHHHHHHHHHHHHH------HT----HHHHH........................................
#=GC SS_cons                         .............ETTEEEEEEHHHHHHHHHHHHHH-HCSS.THHHHHHHHHHHHHHHHHHHHHHHHHHHTT----HHHHHH.HHHHHHHH...H..-T----TT----H.HHHH----HHT-HHHHHHHHHH..T.TT.B-H.HHHHHHHHHHHHHHHHHHHHH------HT----HHHHH........................................
#=GC seq_cons                        ...............t..h.hshsKhpssllpplsc.pssc.clpsWhc-E+psYlSRllNppIDcaChppsspIoscpRcp.lFptlp+c...a...plsLDhpuAQSS.IsHh....Ihusu.FsKKhDcL..s.ss.Ms..slKNpsocplsNhluDphaEK.hp...p............sp....................................
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