GenomeNet

Database: Pfam
Entry: IpgD
LinkDB: IpgD
Original site: IpgD 
#=GF ID   IpgD
#=GF AC   PF05925.13
#=GF DE   Enterobacterial virulence protein IpgD
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_1987 (release 9.0)
#=GF GA   20.70 20.70;
#=GF TC   20.70 20.80;
#=GF NC   20.60 20.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12356723
#=GF RT   Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri
#=GF RT   effector IpgD reorganizes host cell morphology. 
#=GF RA   Niebuhr K, Giuriato S, Pedron T, Philpott DJ, Gaits F, Sable J,
#=GF RA   Sheetz MP, Parsot C, Sansonetti PJ, Payrastre B; 
#=GF RL   EMBO J 2002;21:5069-5078.
#=GF DR   INTERPRO; IPR008108;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several enterobacterial IpgD like
#=GF CC   virulence factor proteins. In the Gram-negative pathogen
#=GF CC   Shigella flexneri, the virulence factor IpgD is translocated
#=GF CC   directly into eukaryotic cells and acts as a potent inositol
#=GF CC   4-phosphatase that specifically dephosphorylates
#=GF CC   phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P(2)] into
#=GF CC   phosphatidylinositol 5-monophosphate [PtdIns(5)P] that then
#=GF CC   accumulates. Transformation of PtdIns(4,5)P(2) into PtdIns(5)P
#=GF CC   by IpgD is responsible for dramatic morphological changes of the
#=GF CC   host cell, leading to a decrease in membrane tether force
#=GF CC   associated with membrane blebbing and actin filament remodelling
#=GF CC   [1].
#=GF SQ   45
#=GS A0A1H0NJB9_9RHIZ/480-994    AC A0A1H0NJB9.1
#=GS A0A1X7ARX1_9GAMM/683-967    AC A0A1X7ARX1.1
#=GS A0A140NP54_PROSM/12-560     AC A0A140NP54.1
#=GS D2VDP8_NAEGR/1396-1561      AC D2VDP8.1
#=GS B6WVV0_9DELT/274-734        AC B6WVV0.1
#=GS A0A081KCQ5_9GAMM/139-490    AC A0A081KCQ5.1
#=GS SOPB_SALTY/1-559            AC O30916.2
#=GS SOPB_SALTY/1-559            DR PDB; 4DID B; 45-171;
#=GS A0A081N7P6_9GAMM/422-845    AC A0A081N7P6.1
#=GS A9MH74_SALAR/1-559          AC A9MH74.1
#=GS F8JFB4_HYPSM/425-909        AC F8JFB4.1
#=GS A0A2T6DWK9_9BACT/467-901    AC A0A2T6DWK9.1
#=GS A0A081NE06_9GAMM/824-1304   AC A0A081NE06.1
#=GS W8WUQ1_CASDE/818-913        AC W8WUQ1.1
#=GS A0A1B7XD49_9DELT/161-612    AC A0A1B7XD49.1
#=GS Q2NVK0_SODGM/1-274          AC Q2NVK0.1
#=GS A0A2P9H9X1_PARUW/205-635    AC A0A2P9H9X1.1
#=GS A0A1Y1R1S8_9GAMM/366-426    AC A0A1Y1R1S8.1
#=GS A0A081K924_9GAMM/327-839    AC A0A081K924.1
#=GS A0A081NMV3_9GAMM/233-621    AC A0A081NMV3.1
#=GS A0A0Q4ME92_9GAMM/21-546     AC A0A0Q4ME92.1
#=GS A0BX02_PARTE/38-152         AC A0BX02.1
#=GS A0A081KCQ5_9GAMM/465-615    AC A0A081KCQ5.1
#=GS W8WUQ1_CASDE/517-773        AC W8WUQ1.1
#=GS IPGD_SHIFL/1-538            AC Q07566.1
#=GS W0I156_9GAMM/199-673        AC W0I156.1
#=GS Q326S4_SHIDS/1-538          AC Q326S4.1
#=GS C7BHR4_PHOAA/47-601         AC C7BHR4.1
#=GS A0A0T9LK82_9GAMM/135-693    AC A0A0T9LK82.1
#=GS A0A081NMY4_9GAMM/346-833    AC A0A081NMY4.1
#=GS A0A081KFU7_9GAMM/2621-3021  AC A0A081KFU7.1
#=GS A0A1Y1R7L9_9GAMM/434-833    AC A0A1Y1R7L9.1
#=GS A0A081NHL1_9GAMM/512-881    AC A0A081NHL1.1
#=GS A0A0P6W6E3_9RHIZ/431-900    AC A0A0P6W6E3.1
#=GS A0A2G3K3E6_9BURK/44-597     AC A0A2G3K3E6.1
#=GS A0A3S2W7T3_9RHIZ/395-868    AC A0A3S2W7T3.1
#=GS A0A1X7AJQ4_9GAMM/648-994    AC A0A1X7AJQ4.1
#=GS A0A447M6L6_SALBN/1-524      AC A0A447M6L6.1
#=GS A0A2X4WGD6_SALER/1-559      AC A0A2X4WGD6.1
#=GS A0A0U5EQC6_9BACT/288-642    AC A0A0U5EQC6.1
#=GS A0A1Y1R1S8_9GAMM/8-364      AC A0A1Y1R1S8.1
#=GS E8LHA9_SUCHY/328-727        AC E8LHA9.1
#=GS A0A081NMV3_9GAMM/614-774    AC A0A081NMV3.1
#=GS A0A0Q9YNT6_9COXI/546-689    AC A0A0Q9YNT6.1
#=GS A0A1X7AG52_9GAMM/322-809    AC A0A1X7AG52.1
#=GS W0I175_9GAMM/144-614        AC W0I175.1
A0A1H0NJB9_9RHIZ/480-994               ................................................................................................adrevietrgtrtnlrpagpehpalqa------.------------------.------....-------------------------------..-------.-------------...-----...------....-...---.....----------.------.......----------..-----KSRIL.E.T...LRTEL-E..Q.AGLPAAE.VDRLTGdRSVGDARRRA.................LNeN.QAWAP.VQRD..Mv..vQK..NGvtR.....T...YQ..SV..ITPA.R..........N...I...S.........P.......R.F..ER..SY.dRT.TYatDG.AptgrlpgGVSSATKG..........NHYHARNLKVS.........EL-H.R.A.D.GTG-HV..TKMIGHGVLDMWD.......IA.............DA.DLRKEANERG...A.AEVIEAAL.AT.N...D...RV...LATA.....H....ArrrdaaG......G....P...VQpilLTH..VSVNLVTP......S....P......Ireyt...vtrplV......GlafrkdmtdyQ.....E......L.............T....YT..KEQ....F.......R.AFEAVs..tGA..A..GA.ARE.VLVADPD.....DP....N........RDVAVaaRVDTIAF..SFAIN.....SL....AT.........G.....T....GgafdvvS........G......WGKVY.EDNRGAMERFIG.....D................LG.SREtgvgsegA.R.PGGFIGSIY...S...Rvd...psD......P....A..Q..V...ELASRLRRQtniVRDLF.VSEDFR....RGRGDPAKMSREiLALqsLAEEalsvmkV.......Dd.qaAT.....M......SKGCKSDKDRGG...VTDV.EIK.....H.....KL...I.TE-...E.MG.G..I..VVPD.ARLAG..DD....QDN..Y.Y..VVAA.SSGQFENQQLNTGLMGSKEAGHLK..----------------------------lripdaav........................................................
A0A1X7ARX1_9GAMM/683-967               rdapravnlmvtrvklgddvilkevrtavpyayavskkaernqitdqrwrdiltlcsvsyfprrvlnnfcpegelskpafavpgfymcllspdnlrppfstfegvdnernwcyeidkkmedls------.------------------.------....-------------------------------..-------.-------------...-----...------....-...---.....----------.------.......----------..----------.-.-...-------..-.-------.------.----------.................--.-.-----.----..-....--..--..-.....-...--..--..----.-..........-...-...-.........-.......-.-..--..--..--.--..--.-.......--------..........-----------.........----.-.-.-.------..-------------.......--.............--.----------...-.--------.--.-...-...--...----.....-....-......-......-....-...--...---..--------......-....-......-............-......-..........-.....-......-.............-....--..---....-.......-.-----....--..-..SK.PLQ.LNIRKRD.....GQ....K........GHITI..RPNLFLF..VCPCN.....QLgyssSL.........D.....F....A......K........A......WENAD.VYNHKAFLKLFGttspdE................PI.KPD.......S.F.VGTFLTEHQ...T...L.......D......P....I..V..L...KEIEEIAYL...LRSMF.TRRLHH....TLGQEPFLFHNY.LSE..LGRL......L.......G....VA.....N......ISGCKSAKDRTG...NY--.---.....-.....--...-.---...-.--.-..-..----.-----..--....---..-.-..----.------------------------..----------------------------ersniemalrlsl...................................................
A0A140NP54_PROSM/12-560                ........................................................................qsishatssgqeqlsktfaynidsvnntiksqklvreaiktpprgqsseer------.------------------.------....-----------------------------KN..NLTNVTQ.DKKD---LIRFQQ...ELLST...AENILK....HldlSTE.....VLATISDKLN.QLTSEP.......SRLIQSRELL..QAKKLEEKLI.K.I...IHHEMLN.sN.NRISLKD.V----G.KLFQKELSRH.................LN.N.KDWHT.IETA..L....SY..GN..S.....E...YS..FI..LTPA.S..........Q...M...K.........Yc.....gG.N..HE..IF..CDnSY..KG.K.......GVCSKSAE..........ETTHAVNLWLS.........EV--.-.K.D.NNQSTL..FSGIRHGVLSPYA......lPE.............RS.AARLQGAKNR...A.KEVVMAAL.FA.K...P...EL...YKRA.....L....N......H......E....E...VT...LRI..ASTSLLT-......-....-......Y............L......G..........K.....E......K.............G....ML..DDQ....V.......A.AWKML....NN..D..G-.VIK.LNIKNEK.....GE....A........QEVKV..KLDIAIF..NFGVN.....EL....AF.........S.....I....P......K........V......ISQND.NLNKTALAQILG.....C................NY.LIN.......N.E.VGGWVGHYL...S...E.......H......Ph..aS..N..R...HKVEELCQQ...IKEIW.KKKSYR....YDGNEPYKIAQR.IAM..LAYE......I.......G....AV.....P......CWNCKSGKDRTG...MLDA.EIK.....R.....EA...I.NYH...Q.GY.S..L..SKPG.AKLTN..EE....KKL..F.Q..GVLL.YSGNKEVQECNTGVAGNKVTKDLPfmLRPLALSYKTRIGDEVIRRQVQGFSSLV................................................................
D2VDP8_NAEGR/1396-1561                 .........................................................................................lerdmyelfgslknlyhskqhekfnqgimesdev------.------------------.------....-------------------------------..-------.-------------...-----...------....-...---.....----------.------.......----------..----------.-.-...-------..-.-------.------.----------.................--.-.-----.----..-....--..--..-.....-...--..--..----.-..........-...-...-.........-.......-.-..--..--..--.--..--.-.......--------..........-----------.........----.-.-.-.------..-------------.......--.............--.----------...-.--------.--.-...-...--...----.....-....-......-......-....-...--...---..--------......-....-......-............-......-..........-.....-......-.............-....--..---....-.......-.-----....--..-..--.---.-------.....--....-........-----..-------..-----.....--....--.........-.....-....-......-........-......-----.------------.....-................--.---.......-.-.---------...-...-.......-......-....-..-..-...---------...-----.------....-KVGDPYAIPVR.VVL..LSFI......I.......G....EQ.....I......HYNCKSGKDRTG...ALMD.ECE....eF.....AE...L.REH...L.SY.YpkP..FTKD.AKLGE..YR....QKI..R.T..NISM.NGGCLEICKQNIGLRGAKLDKTLA..SKFW------------------------tkklydekervvgeipyyrsfkgagyl.....................................
B6WVV0_9DELT/274-734                   ...............................................................rdlsrlmaamqdkktdppelrgladgervpdavmksfnelpgelgnelhrllpdlsagkl------.------------------.------....-------------------------------..-------.-------------...-----...------....-...---.....----------.------.......----------..----------.-.-...-------..-.-------.-----A.KEIKEAHIQV.................LN.E.QDWGV.IRRD..L....QY..LG..RggagvT...AT..ST..ITPA.C..........H...I...G.........A.......G.A..QPgpIG..RSmAR..HGiN.......GVSCEDRG..........QPNHALNLART.........EIAV.-.-.-.GGS-TL..FRGLRHGINSAYS.......IK.............DP.AARRAANATR...A.REIFTAAL.QS.S...P...KLa.dVQRR.....L....A......V......K....AdavID...LPL..LSTSLVTPd...vpR....E......I............F......G..........T....sE......K.............T....YL..AEQ....C.......A.SWKDA....CG..P..DG.TCT.VDVVLPD.....GQ....E........RSVRV..RPQVFTF..NFGVN.....TG....AQ.........Gg...lQ....G......Li......gG......WGTSD.RYNREAMAQLFG.....D................DM.L--.......-.-.-GGMVETYL...G...R.......Sd...isA....R..D..R...QNVQALRYE...IHALW.ATGGYR....MSGADPYRLPAR.LAM..LGHI......M.......G....MM.....P......LFNCKSGKDRTG...QMDV.ACK.....T.....LA...L.QMH...E.NG.G.lL..PPFN.APRSS..MD....RQI..F.Q..QVAI.NGGNLEMQRLNTGLAGFKT-----..----------------------------kgvagldalftd....................................................
A0A081KCQ5_9GAMM/139-490               ......................................................................................................lereleyekqqeyntlnlkgg------.------------------.------....-------------------------------..-------.-------------...-----...------....-...---.....----------.------.......--------EA..ASKTEIKHAK.N.L..sKSLKTRL..EkAGVS---.-KALVT.SNYRQHVN-Q................aLN.E.RNWEV.LHSA..H....QT..NA..G.....T...LE..HR..QVPA.S..........K...M...Q.........LltheeaaG.T..RD..IF..ET.SY..GElG.......GICSQTKD..........SEQHAVNLWTS.........SFS-.-.-.P.PKGKFN..YHGVRHGIHSAIG.......IK.............DS.EQRKTANLNR...A.RESLIAAL.TL.K...P...EL...LNQA.....I....Sn....pA......K....S...VH...LNL..ASVSLVTP......D....P......F............R......I..........Ge..ksE......A.............K....ML..LEQ....I.......E.AFREL....GC..K..-Q.PLK.LSVVNSN.....GR....Q........ITIRI..TFRLALF..NFGVN.....KG....AQgt.....fsR.....M....V......G........G......WKMSD.KLNKEGLHTLIG.....G................T-.-EK.......G.L.TRSIAGDYL...A...K.......Q......-....-..-..Q...QHIITLSTQ...LAD--.------....------------.---..----......-.......-....--.....-......------------...----.---.....-.....--...-.---...-.--.-..-..----.-----..--....---..-.-..----.------------------------..----------------------------srlpdngrkamhnelidlnqk...........................................
SOPB_SALTY/1-559                       ...........................................................................................................................MQIQSF.YHSASLKTQEAFKSLQKT.LYNGMQ....ILSGQGKAPAKAPDARPEIIVLREPGATWGN..YLQHQKA.SNHSLHNLYNLQR...DLLTV...AATVLG....K...QDP.....VLTSMANQME.LAKVKA.......DRPATKQEEA..AAKALKKNLI.E.L...IAARTQQ..Q.DGLPAKE.AHRFAA.VAFRDAQVKQ.................LN.N.QPWQT.IKNT..L....TH..NG..H.....H...YT..NT..QLPA.A..........E...M...K.........I.......G.A..KD..IF..PS.AY..EG.K.......GVCSWDTK..........NIHHANNLWMS.........TVSV.H.E.D.GKDKTL..FCGIRHGVLSPYH.......EK.............DP.LLRHVGAENK...A.KEVLTAAL.FS.K...P...EL...LNKA.....L....A......G......E....A...VS...LKL..VSVGLLTA......S....N......I............F......G..........K.....E......G.............T....MV..EDQ....M.......R.AWQSL....TQ..P..GK.MIH.LKIRNKD.....GD....L........QTVKI..KPDVAAF..NVGVN.....EL....AL.........K.....L....G......F........G......LKASD.SYNAEALHQLLG.....N................DL.RPE.......A.R.PGGWVGEWL...A...Q.......Y......P....D..N..Y...EVVNTLARQ...IKDIW.KNNQHH....KDGGEPYKLAQR.LAM..LAHE......I.......D....AV.....P......AWNCKSGKDRTG...MMDS.EIK.....R.....EI...I.SLH...Q.TH.M..L..SAPG.SLPDS..GG....QKI..F.Q..KVLL.NSGNLEIQKQNTGGAGNKVMKNLS..PEVLNLSYQKRVGDENIWQSVKGISSLI................................................................
#=GR SOPB_SALTY/1-559            SS    ...........................................................................................................................XXXXXX.XXXXXXXXXXXXXXXXXX.XXXXXX....XXXXXXXXXXXXXX----EEEE--SS--GGG..G------.SSSBHHHHHHHHH...HHHHH...HHHHTT....T...S-H.....HHHHHHHHHH.HGGGS-.......--B--HHHHH..HHHHHHHHHH.H.H...HHHHHHH..H.S---HHH.HHHHHH.HHHHHHHHHH.................HT.T.---XX.XXXX..X....XX..XX..X.....X...XX..XX..XXXX.X..........X...X...X.........X.......X.X..XX..XX..XX.XX..XX.X.......XXXXXXXX..........XXXXXXXXXXX.........XXXX.X.X.X.XXXXXX..XXXXXXXXXXXXX.......XX.............XX.XXXXXXXXXX...X.XXXXXXXX.XX.X...X...XX...XXXX.....X....X......X......X....X...XX...XXX..XXXXXXXX......X....X......X............X......X..........X.....X......X.............X....XX..XXX....X.......X.XXXXX....XX..X..XX.XXX.XXXXXXX.....XX....X........XXXXX..XXXXXXX..XXXXX.....XX....XX.........X.....X....X......X........X......XXXXX.XXXXXXXXXXXX.....X................XX.XXX.......X.X.XXXXXXXXX...X...X.......X......X....X..X..X...XXXXXXXXX...XXXXX.XXXXXX....XXXXXXXXXXXX.XXX..XXXX......X.......X....XX.....X......XXXXXXXXXXXX...XXXX.XXX.....X.....XX...X.XXX...X.XX.X..X..XXXX.XXXXX..XX....XXX..X.X..XXXX.XXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXX................................................................
A0A081N7P6_9GAMM/422-845               .......................................................................................................eryarliirrlksigikkae------.------------------.------....-------------------------------..-------.-------------...-----...------....-...---.....----------.------.......----------..----------.-.-...-------..-.-------.------.KKLSEARTRR.................MA.N.VQWET.VETR..LepriNN..RT..L.....N...LK..SR..IIPA.A..........K...F...Q.........Vhm..grpG.N..VD..IF..PA.HL..HG.K.......GKPSSKRD..........EADNAVNLGET.........QLLV.E.Q.G.GKSKSL..FRGLRSGTFMAFG.......IS.............NK.KKREQANDAR...C.YDLAIASL.KQ.V...L...DD...DPGV.....L....N......H......Q....P...VP...VKL..STLQLLTPdrgrhyS....H......I............H......D..........D.....E......L.............K....MQ..REQ....M.......E.ALHRL...kDR..L..DD.GEP.LVFADSS.....GR....L........HEVDV..EFDFAAT..NFGVN.....NL....ALe.......kK.....W....R......Ft......gP......WGAVR.DANREGLEKLMG.....G................-V.EPG.......D.E.VGGWAQDFL...N...G.......P......A....S..EkdK...EIVMQLIEQ...IRDLY.ESEDYK....NEGEDAYKMVAR.VLL..LSYK......L.......G....LI.....T......HFNCKSGKDRTG...EADA.AAK.....R.....LA...A.EVE...A.LG.Y..V..PDPR.QVASQ..EE....RTL..S.Q..LFAL.ETGNVRWQQMNINRPGYKT-----..----------------------------ttgikrlgkklf....................................................
A9MH74_SALAR/1-559                     ...........................................................................................................................MQIQSF.YHSALLKSQEAFKSLQKT.LYNGMQ....ILSGQGKAPAKAPDARPEIIVLREPGATWGN..YLQNQKT.SNHSLHHIYDLQR...DLLTV...TATVLG....K...QDP.....VLMAMANQME.LAKVKA.......DRPATKQEEA..AAKTLKKNLI.E.L...IAARTQQ..Q.NGLPAKE.AHRLAA.EMFKDAQVKQ.................LN.S.QSWQT.IKNT..L....IH..NG..H.....H...YT..NT..QLPA.A..........D...M...K.........I.......D.T..KD..IF..PS.AY..QG.K.......GVCSWDTQ..........NIHHATNLWMS.........TVST.H.E.D.GKDKTL..FCGIRHGVLSPYG.......VK.............DP.LLRQVGAENR...A.KEVLTAAL.FS.K...P...EL...LESA.....L....K......G......E....A...VS...LKL..VSVGLLTA......S....N......V............L......G..........Q.....E......G.............T....MV..EDQ....M.......R.AWQSL....TQ..P..GK.MIH.LKIRNKD.....GE....L........QTVKI..KPEVAAF..NVGVN.....EL....AL.........K.....L....G......F........G......LKASD.RYNIEALHQLLG.....N................DL.RPE.......A.R.PGGWVGNWL...A...Q.......Y......P....D..N..Y...EVVNKLARQ...IKDIW.KNNLHH....KDGGEPYKLAQR.LAM..LANE......I.......D....AV.....P......AWNCKSGKDRTG...MMDS.EIK.....R.....EV...I.SFH...Q.TH.T..L..NAPG.NLPDR..SG....QEI..F.Q..KVLL.NSGNLEIQKLNTGGAGNKVMKNLS..PEVLNLSYQKRIGNENIWQSVKGISSLI................................................................
F8JFB4_HYPSM/425-909                   ....................hpaiqakkatqkwlkdnmreaglprsvvkeltasnkmsqarravlnantdwapyrrnmivsrdgvtrayqsaitpgafisarfarryastvpldgasaphpsr------.------------------.------....-------------------------------..-------.-------------...-----...------....-...---.....----------.------.......----------..----------.-.-...-------..-.-------.------.----------.................--.-.-----.----..-....--..--..-.....-...--..--..----.-..........-...-...-.........-.......-.-..--..--..--.--..--.N.......GVSSAEKA..........DHYHARNLKVSelfrlddqnQIEM.D.A.N.GQPKAM..AKVIGHGVLDMWE.......IE.............NS.AERFAANERG...A.KEVLEAAL.TT.N...P...RV...LQTA.....I....N......G......Q....P...VT...LTH..VSVNLTTP......S....E......V............ReypilrGai.....pdyQ.....E......L.............T....FT..QEQ....F.......R.VFGT-....YK..A..NQ.PAQ.FTVADPA.....GGptapE........QNVLV..NVDPITF..SFGIN.....HL....AT........sK.....L....G......-........G......WKNVA.ERNKEAIVKFIG.....Dpg...........sgrDG.DRG.......L.P.IGGFIGSII...D...RlngiggvN......P....A..A..KtlaNKMRQQANQ...VRLLY.TAAVYK....NDNGDPAKMGREiLAL..QALA......EnaldlmgDagqaAT.....M......SKGCKSDKDRGG...VTDV.ELK.....H.....KL...I.TED...M.GG.E..I..WA-D.SPWTE..ED....HEN..Y.Y..VVGV.ASGQLENQRLNTGFAGSKEAAKLQ..HHV-------------------------hkadvrqy........................................................
A0A2T6DWK9_9BACT/467-901               .................................................................................asfdpiheqyefrsgekvttvtsditparnlpalqglyqmhg------.------------------.------....-------------------------------..-------.-------------...-----...------....-...---.....----------.------.......----------..----------.-.-...-------..-.-------.------.----------.................--.-.-----.----..-....--..--..-.....-...--..--..----.-..........-...-...-.........-.......-.-..--..--..--.--..-I.R.......GVSSGSSK..........ESRHAVNLAVT.........KATV.-.-.-.GGN-VV..FEGIRHGVLSAFG......vPKgiiatikswftgsDP.DARKVANRNR...A.MEVVTAAT.GTlD...P...AK...LRQA.....I...qS......G......Q....P...VD...LSI..GSIGLLTP......D....N......TrrfldfisngkaF......G..........Da...nE......F.............E....QM..NDQ....F.......Q.AWKDV....EG..-..VQ.TVM.VEHPDNP.....GQ....L........VPIQV..RVDTMAF..NFGVN.....EG....AV.........Kg...kF....G......FdsswrhtgG......WQNVK.DQNKVAMEKLMG.....T................DL.SNE.......S.ApIGGKLKAYL...D...D.......P......Hv.ldS..D..K...AIARELATQ...IRFMW.NNESYM....EQGGEPYKMVAR.LAV..LTHM......M.......G....IK.....C......CFNCKSGKDRTG...MLDS.HAK.....H.....LA...T.QIA...V.EG.R..V..PALG.ILPDE..RG....KFN..E.R..QAVL.RGGSLKMQEYNVGLGGYKLNK---..----------------------------vddnffriggsgrkkdqvvnpgimraieggsdlv..............................
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