GenomeNet

Database: Pfam
Entry: Izumo-Ig
LinkDB: Izumo-Ig
Original site: Izumo-Ig 
#=GF ID   Izumo-Ig
#=GF AC   PF16706.6
#=GF DE   Izumo-like Immunoglobulin domain
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   [1]
#=GF GA   26.70 26.70;
#=GF TC   26.70 26.80;
#=GF NC   26.60 26.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Immunoglobulin_superfamily
#=GF RN   [1]
#=GF RM   16574441
#=GF RT   The molecular players of sperm-egg fusion in mammals.
#=GF RA   Rubinstein E, Ziyyat A, Wolf JP, Le Naour F, Boucheix C;
#=GF RL   Semin Cell Dev Biol. 2006;17:254-263.
#=GF RN   [2]
#=GF RM   15759005
#=GF RT   The immunoglobulin superfamily protein Izumo is required for
#=GF RT   sperm to fuse with eggs.
#=GF RA   Inoue N, Ikawa M, Isotani A, Okabe M;
#=GF RL   Nature. 2005;434:234-238.
#=GF DR   INTERPRO; IPR032699;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Izumo-Ig is the immunoglobulin domain on Izumo proteins from
#=GF CC   higher eukaryotes. Izumo is a typical type I membrane
#=GF CC   glycoprotein with one immunoglobulin-like domain and a putative
#=GF CC   N-glycoside link motif - glycosylation site. The full-length
#=GF CC   protein, eg Swiss:Q8IYV9, is a molecule with a single
#=GF CC   immunoglobulin (Ig) domain. It is thought that Izumo proteins
#=GF CC   bind to putative Izumo receptors on the oocyte.  Izumo is not
#=GF CC   detectable on the surface of fresh sperm but becomes exposed
#=GF CC   only after an exocytotic process, the acrosome reaction, has
#=GF CC   occurred. Studies have shown that knock-out mice (Izumo-/-
#=GF CC   males) were sterile despite normal mating behaviour and
#=GF CC   ejaculation, indicating the importance of the protein in
#=GF CC   fertilisation [1]. There is a conserved GCL sequence motif.
#=GF CC   Izumo expression has been found to be testis-specific [1,2].
#=GF SQ   120
#=GS E1BDA8_BOVIN/169-256      AC E1BDA8.3
#=GS IZUM1_RAT/168-255         AC Q6AY06.1
#=GS A0A2U3WZY4_ODORO/168-255  AC A0A2U3WZY4.1
#=GS A0A2Y9PE52_DELLE/232-319  AC A0A2Y9PE52.1
#=GS A0A2R9A1Y2_PANPA/168-255  AC A0A2R9A1Y2.1
#=GS A0A2K6FJK7_PROCO/168-255  AC A0A2K6FJK7.1
#=GS A0A455ATP9_PHYMC/71-158   AC A0A455ATP9.1
#=GS A0A2K5RHC0_CEBCA/141-228  AC A0A2K5RHC0.1
#=GS A0A1S3G4U8_DIPOR/168-202  AC A0A1S3G4U8.1
#=GS G1TVX5_RABIT/168-255      AC G1TVX5.1
#=GS G1QXF7_NOMLE/168-255      AC G1QXF7.1
#=GS M3XLJ0_LATCH/158-246      AC M3XLJ0.1
#=GS L5L4K5_PTEAL/134-221      AC L5L4K5.1
#=GS A0A2I4AR79_9TELE/133-226  AC A0A2I4AR79.1
#=GS A0A060Y0K2_ONCMY/179-274  AC A0A060Y0K2.1
#=GS IZUM1_HUMAN/168-255       AC Q8IYV9.2
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JKE C; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5F4V A; 168-255;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5F4T A; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5F4E A; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JK9 D; 168-250;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JK9 C; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JK9 B; 168-255;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JKC A; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JK9 F; 168-255;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JKD A; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JK9 E; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JK9 A; 168-255;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JKE A; 168-254;
#=GS A0A340XT57_LIPVE/169-256  AC A0A340XT57.1
#=GS A0A2Y9P400_DELLE/225-312  AC A0A2Y9P400.1
#=GS A0A1S3G3S8_DIPOR/168-208  AC A0A1S3G3S8.1
#=GS A0A3Q7UBR6_URSAR/168-255  AC A0A3Q7UBR6.1
#=GS A0A455AUE3_PHYMC/169-244  AC A0A455AUE3.1
#=GS A0A2Y9PC44_DELLE/196-283  AC A0A2Y9PC44.1
#=GS H9H653_MONDO/205-293      AC H9H653.2
#=GS A0A2D0QWP8_ICTPU/207-300  AC A0A2D0QWP8.1
#=GS G1M882_AILME/167-254      AC G1M882.1
#=GS A0A3Q7UQT5_VULVU/137-223  AC A0A3Q7UQT5.1
#=GS G3QFY5_GORGO/168-255      AC G3QFY5.2
#=GS A0A4D9DSM3_9SAUR/146-232  AC A0A4D9DSM3.1
#=GS A0A2K5ICP7_COLAP/168-255  AC A0A2K5ICP7.1
#=GS A0A2Y9P1F4_DELLE/232-319  AC A0A2Y9P1F4.1
#=GS A0A2U4APC0_TURTR/27-114   AC A0A2U4APC0.1
#=GS A0A383YZJ7_BALAS/115-202  AC A0A383YZJ7.1
#=GS A0A0D9S2Z4_CHLSB/170-257  AC A0A0D9S2Z4.1
#=GS A0A3Q7TIP7_VULVU/166-252  AC A0A3Q7TIP7.1
#=GS F6Y5G2_ORNAN/150-214      AC F6Y5G2.2
#=GS A0A384BKU3_URSMA/168-256  AC A0A384BKU3.1
#=GS A0A1U7QS27_MESAU/168-255  AC A0A1U7QS27.1
#=GS A0A2K5MSM3_CERAT/168-255  AC A0A2K5MSM3.1
#=GS A0A337SB10_FELCA/168-255  AC A0A337SB10.1
#=GS A0A2Y9PE60_DELLE/169-256  AC A0A2Y9PE60.1
#=GS F6XH82_MACMU/168-255      AC F6XH82.1
#=GS K7DZS4_MONDO/205-254      AC K7DZS4.1
#=GS A0A3P8PKE0_ASTCA/159-254  AC A0A3P8PKE0.1
#=GS IZUM1_MOUSE/168-255       AC Q9D9J7.1
#=GS IZUM1_MOUSE/168-255       DR PDB; 5B5K A; 168-255;
#=GS A0A1S3NNW2_SALSA/125-220  AC A0A1S3NNW2.1
#=GS L9J9G8_TUPCH/134-218      AC L9J9G8.1
#=GS F1RIQ7_PIG/171-258        AC F1RIQ7.2
#=GS A0A3Q0DGU8_TARSY/55-142   AC A0A3Q0DGU8.1
#=GS A0A3B3TML9_9TELE/86-182   AC A0A3B3TML9.1
#=GS A0A2D0QWQ3_ICTPU/187-280  AC A0A2D0QWQ3.1
#=GS H3DD44_TETNG/56-151       AC H3DD44.1
#=GS A0A455ASF7_PHYMC/162-249  AC A0A455ASF7.1
#=GS A0A3Q0GZH2_ALLSI/57-141   AC A0A3Q0GZH2.1
#=GS G3HZX1_CRIGR/395-482      AC G3HZX1.1
#=GS A0A3Q1DAP6_AMPOC/159-254  AC A0A3Q1DAP6.1
#=GS A0A2Y9L336_ENHLU/282-369  AC A0A2Y9L336.1
#=GS A0A3Q0GVU8_ALLSI/60-144   AC A0A3Q0GVU8.1
#=GS A0A2K6SYH0_SAIBB/168-255  AC A0A2K6SYH0.1
#=GS A0A287CWI4_ICTTR/169-256  AC A0A287CWI4.1
#=GS A0A2Y9P6M3_DELLE/134-221  AC A0A2Y9P6M3.1
#=GS A0A3Q2KUM8_HORSE/168-255  AC A0A3Q2KUM8.1
#=GS W5PRD0_SHEEP/169-256      AC W5PRD0.1
#=GS A0A2Y9PC54_DELLE/232-317  AC A0A2Y9PC54.1
#=GS A0A455AS83_PHYMC/232-319  AC A0A455AS83.1
#=GS A0A2U4APR3_TURTR/169-244  AC A0A2U4APR3.1
#=GS A0A091D708_FUKDA/184-271  AC A0A091D708.1
#=GS A0A452R3V2_URSAM/168-256  AC A0A452R3V2.1
#=GS A0A2K6LQN1_RHIBE/168-255  AC A0A2K6LQN1.1
#=GS C6ZEA2_CAPHI/169-256      AC C6ZEA2.1
#=GS A0A2K5DEQ1_AOTNA/168-255  AC A0A2K5DEQ1.1
#=GS A0A452C6X0_BALAS/71-158   AC A0A452C6X0.1
#=GS A0A2Y9P1F7_DELLE/169-256  AC A0A2Y9P1F7.1
#=GS A0A383YZS1_BALAS/169-244  AC A0A383YZS1.1
#=GS A0A2K6ADS1_MANLE/168-255  AC A0A2K6ADS1.1
#=GS A0A3B1K9P2_ASTMX/111-192  AC A0A3B1K9P2.1
#=GS A0A2Y9P6L9_DELLE/232-307  AC A0A2Y9P6L9.1
#=GS M7B083_CHEMY/16-89        AC M7B083.1
#=GS A0A1S3G3D2_DIPOR/168-204  AC A0A1S3G3D2.1
#=GS A0A2U4APB7_TURTR/169-256  AC A0A2U4APB7.1
#=GS G3VSG5_SARHA/195-279      AC G3VSG5.1
#=GS A0A2K5DEP7_AOTNA/168-255  AC A0A2K5DEP7.1
#=GS A0A3L8Q968_CHLGU/44-82    AC A0A3L8Q968.1
#=GS G5BAH6_HETGA/168-255      AC G5BAH6.1
#=GS A0A383YZK9_BALAS/169-256  AC A0A383YZK9.1
#=GS A0A1S3AJR4_ERIEU/169-256  AC A0A1S3AJR4.1
#=GS F6YE25_HORSE/168-255      AC F6YE25.2
#=GS H0WN21_OTOGA/168-255      AC H0WN21.1
#=GS A0A3Q7VIE1_URSAR/168-256  AC A0A3Q7VIE1.1
#=GS A0A2D0QYA3_ICTPU/207-284  AC A0A2D0QYA3.1
#=GS G3TPD8_LOXAF/168-255      AC G3TPD8.1
#=GS A0A1A6G4T1_NEOLE/121-208  AC A0A1A6G4T1.1
#=GS A0A2U4APA6_TURTR/162-249  AC A0A2U4APA6.1
#=GS A0A1S3NNR7_SALSA/185-280  AC A0A1S3NNR7.1
#=GS A0A2U4APB1_TURTR/169-256  AC A0A2U4APB1.1
#=GS A0A1S3NNQ8_SALSA/160-255  AC A0A1S3NNQ8.1
#=GS A0A287DEN9_ICTTR/162-249  AC A0A287DEN9.1
#=GS A0A2K6NEL4_RHIRO/168-255  AC A0A2K6NEL4.1
#=GS A0A2Y9P405_DELLE/232-319  AC A0A2Y9P405.1
#=GS A0A3Q7TNL9_URSAR/143-231  AC A0A3Q7TNL9.1
#=GS A0A2R8QHQ6_DANRE/165-258  AC A0A2R8QHQ6.1
#=GS A0A3P8YQM3_ESOLU/95-188   AC A0A3P8YQM3.1
#=GS A0A3Q7V496_URSAR/168-256  AC A0A3Q7V496.1
#=GS A0A2D0QYZ5_ICTPU/207-300  AC A0A2D0QYZ5.1
#=GS A0A2U4APC4_TURTR/169-256  AC A0A2U4APC4.1
#=GS A0A0A0MU86_PAPAN/168-255  AC A0A0A0MU86.2
#=GS A0A2Y9DWR9_TRIMA/168-255  AC A0A2Y9DWR9.1
#=GS A0A2K6C510_MACNE/141-228  AC A0A2K6C510.1
#=GS A0A1A6GNX2_NEOLE/157-244  AC A0A1A6GNX2.1
#=GS A0A096LWR2_POEFO/164-257  AC A0A096LWR2.1
#=GS A0A2K5UGJ7_MACFA/168-255  AC A0A2K5UGJ7.1
#=GS A0A2Y9EZU1_PHYMC/169-256  AC A0A2Y9EZU1.1
#=GS F7H859_CALJA/168-255      AC F7H859.2
#=GS H2QGS4_PANTR/168-255      AC H2QGS4.1
#=GS A0A2U4APA9_TURTR/133-220  AC A0A2U4APA9.1
#=GS G1P6T7_MYOLU/171-258      AC G1P6T7.1
#=GS A0A3B3XUR9_9TELE/77-166   AC A0A3B3XUR9.1
#=GS A0A498MAL9_LABRO/133-183  AC A0A498MAL9.1
#=GS F6UM65_CANLF/166-252      AC F6UM65.1
#=GS A0A2U3YV44_LEPWE/168-255  AC A0A2U3YV44.1
#=GS A0A383YZJ5_BALAS/140-227  AC A0A383YZJ5.1
E1BDA8_BOVIN/169-256                 .........................................REVKVHHMEDMILDCELNWHKISQGLTDYSF........YRVWKNNSETLVSKGKEPIL...TKTMVRPKDAGTYRCELGSI.QSSPATIIYFHVTVLPK...................
IZUM1_RAT/168-255                    .........................................RQIEVHRLEDMVLDCQLSWHHASEGLTDYSF........YRVWGNSSETLMSKGKEPYL...TKTMVGPEDAGNYRCELDTV.NAGPATIIYYHVTVLP-p..................
A0A2U3WZY4_ODORO/168-255             ........................................r-PVIVHEMEDLILNCELNWHRLSQGLTDYNF........FRVWGRDSETLLYKGKNPTL...IKTAVTAEDAGVYRCSLDSV.RSIPATIILYEVKVLPK...................
A0A2Y9PE52_DELLE/232-319             .........................................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGNNSETLMSKGKEPTL...TKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK...................
A0A2R9A1Y2_PANPA/168-255             .........................................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGNNTETLVSKGKEATL...TKPMVGPEDAGSYRCELGSV.NSSPATIINFHVTVLPK...................
A0A2K6FJK7_PROCO/168-255             .........................................RKVEVHQMEDMILDCELNWHHASEGLSYYRF........YRVWENNTETLVSMRTAPTL...TKPMVGPKDAGRYRCELGSV.NSSPATIIYFNVTVLP-t..................
A0A455ATP9_PHYMC/71-158              .........................................RQVKVHQMEDMILDCELNWHKVSQGLTDYSF........YRVWGNNSETLMSKGKEPTL...TKTMVRPKDAGTYRCELGSV.RSSPATIIYFHVTVLPK...................
A0A2K5RHC0_CEBCA/141-228             .........................................RNVDVPHMEDMILDCELNWHKASEGLTDYSF........YRVWGNNTETLVSKGKEPTL...TKPMVGPEDAGDYRCELGTV.NSSPATIIFFHVTVLPK...................
A0A1S3G4U8_DIPOR/168-202             ........................................h-SVKVHEMEDIILDCHLNWHHASQGLADYSF........YR------------------...--------------------.-----------------gp.................
G1TVX5_RABIT/168-255                 ......................................hrs---EVHQMDDLILDCKLSWHQASQGLTDYSF........YRVWGNNSETLMAKGKAHLL...TKPLVGPEDAGTYRCELGTV.SSGPATIMRFQVTVLP-p..................
G1QXF7_NOMLE/168-255                 .........................................RNVEVPQMEDMMLDCELNWHQASEGLTDYSF........YRVWGNNTETLVSKGKEATL...TKPMVGPEDAGSYRCELGSV.NSSPATIINFHVTVLPK...................
M3XLJ0_LATCH/158-246                 .........................................RNISVSEFDSLRLDCSEPWHFKVQNKGLFTFn......vDLAEAGSPRTYLFASESPYL...VINGITLEHQGTYHCQLTDR.DGDIVSEKRFEVNV---hs.................
L5L4K5_PTEAL/134-221                 .........................................REVTVHAMEDMILDCELNWHHASEGLTDYSF........FRVWTNKSETLVSKGKEPTL...TKTMVDSKDAGTYRCQLDTV.QSSPATIIYFNVSVLPK...................
A0A2I4AR79_9TELE/133-226             ........................................p--VEAEEGGQAVLNCFVSWHRLLLGNPEYYYswa.petgNKELDEKDFTALVVTEDSFV...VLNQLHLDEQGTYQCSLRDQ.NGTVFYRVTFLLSVAP-l..................
A0A060Y0K2_ONCMY/179-274             .......................................yp--VQAAEGGQAVLDCFLPWHSLVVGRPDYHYtwapgtqrTANLTEGDFRVLVVTEDSSV...VLNQLHVDEEGMYRCLLTDG.KGTVLSRTHFLLTVTP-s..................
IZUM1_HUMAN/168-255                  .........................................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGNNTETLVSKGKEATL...TKPMVGPEDAGSYRCELGSV.NSSPATIINFHVTVLPK...................
#=GR IZUM1_HUMAN/168-255       SS    .........................................EEEEEETTS-EEEE---GGGGGSCSEEEEEE........EEE-TTS-EEEEEEES-SEE...EESS--GGG-EEEEEEEEES.SSSESEEEEEEEEEEST...................
A0A340XT57_LIPVE/169-256             .........................................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGNNSETLMSKGKEPTL...TKTMVRPKDAGTYRCELGSV.QSSPATVIYFHVTVLPK...................
A0A2Y9P400_DELLE/225-312             .........................................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGNNSETLMSKGKEPTL...TKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK...................
A0A1S3G3S8_DIPOR/168-208             ........................................h-SVKVHEMEDIILDCHLNWHHASQGLADYSF........YRVGSCN-------------...--------------------.-----------------ssk................
A0A3Q7UBR6_URSAR/168-255             .........................................REVTVHEMEDLRLNCELSWHRLSQGLANYNF........FRVWGTKAETLLYTGNDHTL...TKPAVTAEDAGVYRCSLDTV.RSGPATIIHFHVRVLPR...................
A0A455AUE3_PHYMC/169-244             .........................................RQVKVHQMEDMILDCELNWHKVSQGLTDYSF........YR------------GKEPTL...TKTMVRPKDAGTYRCELGSV.RSSPATIIYFHVTVLPK...................
A0A2Y9PC44_DELLE/196-283             .........................................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGNNSETLMSKGKEPTL...TKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK...................
H9H653_MONDO/205-293                 ........................................q-AVQVIEKGDLILDCELSWHKKAEGLTTYSF........FKILTNGTEVLLSRGKDSAL...TKPMVAFEDGGSYRCILDTIrKHSPATIIVYRVQVIPD...................
A0A2D0QWP8_ICTPU/207-300             .......................................hk--LVAHEGEQTVLDCFLPWHSLVVGHAKYQYswk..rgaTNFSAKDEFEVLVVTKDSKI...VLNQLSVSEQGVYRCILLDQ.HGTTLSHTHFILTVIP-m..................
G1M882_AILME/167-254                 .........................................REITVHEMEDLRLNCELSWHRLSQGLASYNF........FRVWGTKSETLLYTGNDHTL...TKPAVTAEDAGVYRCSLDTV.SSGPATIIHYHVRVLPR...................
A0A3Q7UQT5_VULVU/137-223             .........................................HEVVVHELEDLVLDCELSWHRISAGVNNYTF........YRVLGSNS-LLLSVGKEPTL...TKTMVRLEDAGTYRCELANM.KTSRAGVTHFHVRVLPQ...................
G3QFY5_GORGO/168-255                 .........................................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGNNTETLVSKGKEATL...TKPMVGPEDAGSYRCELGSV.NSSPATIINFHVRVLPK...................
A0A4D9DSM3_9SAUR/146-232             .........................................RRLRVQQDDDLILDCALTWHRASYGAKSYRF........YRAAGGSE-QVMVMGPDAFL...VKKEATANDSGRYRCEMLNA.QGWVCSELRFQVTVTP-l..................
A0A2K5ICP7_COLAP/168-255             .........................................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGNNTETLVSKGKEPTL...TKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK...................
A0A2Y9P1F4_DELLE/232-319             .........................................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGNNSETLMSKGKEPTL...TKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK...................
A0A2U4APC0_TURTR/27-114              .........................................RKVKVHQMEDMILDCELNWHKLSQGLTDYSF........YRVWGKNSETLMSKGKEPTL...TKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK...................
A0A383YZJ7_BALAS/115-202             .........................................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGNHSETLMSKGKEPTL...TKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK...................
A0A0D9S2Z4_CHLSB/170-257             .........................................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGNNTETLVSKGKEPTL...TKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK...................
A0A3Q7TIP7_VULVU/166-252             .........................................HEVVVHELEDLVLDCELSWHRISAGVNNYTF........YRVLGSNS-LLLSVGKEPTL...TKTMVRLEDAGTYRCELANM.KTSRAGVTHFHVRVLPQ...................
F6Y5G2_ORNAN/150-214                 ...................................dhslpp-----------------------------TF........VGVWANRTEQLLARSPDPFL...RRPLVTLEDAGTYRCTLDTA.SHEVATEMRYQVTVTP-t..................
A0A384BKU3_URSMA/168-256             .........................................REVTVHEMEDLRLNCELSWHRLSQGLANYNF........FRVWGTKAETLLYTGNDHTL...TKPAVTAEDAGVYRCSLDTV.RSGPATIIHFHVR----glllp..............
A0A1U7QS27_MESAU/168-255             .........................................RRIEVHRLEDLVLDCQLSWHHASEGLTDYSF........YRVWGNSSETLLSKGKEPYM...TKSMVGPEDAGNYRCELGTV.NAGPATIIHFRVIVLPQ...................
A0A2K5MSM3_CERAT/168-255             .........................................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGNNTETLVSKGKEPIL...TKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK...................
A0A337SB10_FELCA/168-255             .........................................RHINVHEKEDLVLDCELHWHKLSQGLTYYSF........YRVWGSNSETLVYKGKQPTL...TKPLVGPEDAGDYRCELGTV.RSLPATVIHFKVTVLPQ...................
A0A2Y9PE60_DELLE/169-256             .........................................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGNNSETLMSKGKEPTL...TKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK...................
F6XH82_MACMU/168-255                 .........................................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGNNTETLVSKGKEPTL...TKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK...................
K7DZS4_MONDO/205-254                 ........................................q-AVQVIEKGDLILDCELSWHKKSEGLTDYSF........YKILTNGTEVLLSQGQ----...--------------------.-----------------gfg................
A0A3P8PKE0_ASTCA/159-254             .......................................yp--VQAEEGGQALLNCFLPWHRLLLGRPEYHYswvpgaseTDKMNESDFSVLVVTEDSSI...VLNQLRLDEEGTYRCSLQAQ.NGTIFYQATFPLTVI--ss.................
IZUM1_MOUSE/168-255                  .........................................RHIEVHRSEDLVLDCLLSWHRASKGLTDYSF........YRVWENSSETLIAKGKEPYL...TKSMVGPEDAGNYRCVLDTI.NQGHATVIRYDVTVLP-p..................
#=GR IZUM1_MOUSE/168-255       SS    .........................................EEEEEETTS-EEEE---GGGGT-SSEEEEEE........EEE-TTS-EEEEEEES-SEE...EE-S--GGG-EEEEEEEEES.SS-EEEEEEEEEEEE---..................
A0A1S3NNW2_SALSA/125-220             .......................................yp--VEAAEGGQAVLDCFLPWHSLVVGQPDYHYtwapgtqrTANLTEGDFRVLVVTEDSSV...VLNQLHVDEEGMYRCLLTDG.KGTVLSRTHFLLTVTP-s..................
L9J9G8_TUPCH/134-218                 .........................................RQVEVYEMEDLILDCELNWHHASQGLTEYSF........YRVWANDSETLVSRKKEPTL...TKPMVGPEDEGNYRCELGTV.NSGPATIIYFHVT----g..................
F1RIQ7_PIG/171-258                   .........................................RKVKVHQMEDMILDCELNWHKVSQGLTDYSF........YRVWKNNSETLMAKGQEPTL...TKTMVSPKDAGTYRCELGTV.QSTPATIIHFHVTVLPK...................
A0A3Q0DGU8_TARSY/55-142              .........................................RRVKVHQMEDMILDCEFNWHRASEGLTDYSF........YRVWGNHSETLVSKGKEPTL...TKPMVGQEDAGSYRCELGTV.TSEPGLLFDPSLPVLPK...................
A0A3B3TML9_9TELE/86-182              qcveswqcglktmtvtsgqrveidldvvlslrvswryargv-------------------------------........----ITSDDSLFDRWKAPDLqrvVLDPVREEDAGTYRCDVQDA.NYRRKKTVYWGVRVLP-a..................
A0A2D0QWQ3_ICTPU/187-280             .......................................hk--LVAHEGEQTVLDCFLPWHSLVVGHAKYQYswk..rgaTNFSAKDEFEVLVVTKDSKI...VLNQLSVSEQGVYRCILLDQ.HGTTLSHTHFILTVIP-m..................
H3DD44_TETNG/56-151                  ........................................n-TVQAEEGGQAVLDCLQPWHHLLMGRPEYHFswapgvpgTKTVNESNFIVLVVTEDSSL...VLNQLRLDEQGTYRCSLQDQ.NETVFYQVHFLLTVAP-l..................
A0A455ASF7_PHYMC/162-249             .........................................RQVKVHQMEDMILDCELNWHKVSQGLTDYSF........YRVWGNNSETLMSKGKEPTL...TKTMVRPKDAGTYRCELGSV.RSSPATIIYFHVTVLPK...................
A0A3Q0GZH2_ALLSI/57-141              .........................................RKLEVEEDEDLILDCALTWHHVSYGIKNYIF........YRVWGHTEQH-IVSGPDPFL...VRKEVTVNDSGSYRCEMRDA.KNMLCSQMQFQVT----ge.................
G3HZX1_CRIGR/395-482                 .........................................RRIEVHRMEDMVLDCQLSWHHASEGLTEYSF........YKVWGNSSETLMSKGREPYM...TKTMVGPEDAGNYRCELGTI.NAGPATIIHFRVIVL--ga.................
A0A3Q1DAP6_AMPOC/159-254             .......................................hp--VQAEEGGQAVLDCFLPWHRLLLGKPEYHYfwapgapgTETLDESDFKALVVTDDSSV...VLNQLRVDEQGTYRCSLQDR.NGTIFYQITFLLTVAP-l..................
A0A2Y9L336_ENHLU/282-369             ........................................r-VVLVHEKEDMILNCELNWHRLSQGLTNYSF........FRVWGQNSETLLSEGKDPIL...TKTAVTAEDAGVYRCRLGTV.RSIPATILFFRVTVLPE...................
A0A3Q0GVU8_ALLSI/60-144              .........................................RKLEVEEDEDLILDCALTWHHVSYGIKNYIF........YRVWGHTEQH-IVSGPDPFL...VRKEVTVNDSGSYRCEMRDA.KNMLCSQMQFQVT----ge.................
A0A2K6SYH0_SAIBB/168-255             .........................................RNVEVPHMEDMILDCELNWHKASEGLTDYSF........YRVWGNNTETLVSKGKEPTL...TKPVVGPEDAGDYRCELGTV.NSSPATIILFHVTVLPK...................
A0A287CWI4_ICTTR/169-256             ......................................rve---EIHEHEALNLNCFLDWHKEAVGLTNYVF........YRVWENNSETVLYSGKDPVF...NRPSASVNDSGKYRCELGTI.YNRPSTIIHFLVTVLPR...................
A0A2Y9P6M3_DELLE/134-221             .........................................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGNNSETLMSKGKEPTL...TKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK...................
A0A3Q2KUM8_HORSE/168-255             .........................................RQVKVHRKEDMILDCELNWHRASEGLTDYSF........YRVWGKNDETLVSKGKEPTL...TKTMVGPEDQGTYRCELGTV.QSDPATIIYFHVTVLPQ...................
W5PRD0_SHEEP/169-256                 .........................................REVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWKNNSETLVSRGKEPIL...TKTMVRPKDAGTYRCELGSI.QSSPATIIYFHVTVLPK...................
A0A2Y9PC54_DELLE/232-317             .........................................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGNNSETLMSKGKEPTL...TKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVT----gp.................
A0A455AS83_PHYMC/232-319             .........................................RQVKVHQMEDMILDCELNWHKVSQGLTDYSF........YRVWGNNSETLMSKGKEPTL...TKTMVRPKDAGTYRCELGSV.RSSPATIIYFHVTVLPK...................
A0A2U4APR3_TURTR/169-244             .........................................RKVKVHQMEDMILDCELNWHKLSQGLTDYSF........YR------------GKEPTL...TKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK...................
A0A091D708_FUKDA/184-271             .........................................RSVEVHQMEDMILDCHLNWHQASQGLTDYSF........YRVWGNNSETLVSKGKESLL...TKPLVGPEDAGDYLCELGTV.SYGPATIINFHVTVLPE...................
A0A452R3V2_URSAM/168-256             .........................................REVTVHEMEDLRLNCELSWHRLSQGLANYNF........FRVWGTKAETLLYTGNDHTL...TKPAVTAEDAGVYRCSLDTV.RSGPATIIHFHVR----glllp..............
A0A2K6LQN1_RHIBE/168-255             .........................................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGNNTETLVSKGKEPTL...TKSMVGPEDAGRYRCELGSV.NSSPATVINFRVTVLPE...................
C6ZEA2_CAPHI/169-256                 .........................................REVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWKNNSETLVSRGKEPIL...TKTMVRPKDAGTYRCELGSI.QSSPATIIYFHVTVLPK...................
A0A2K5DEQ1_AOTNA/168-255             .........................................RDVEVPRMEDMILDCELNWHKASEGLTDYSF........YRVWGNNTETLVSKGKEPTL...TKPMVGPEDAGDYRCELDTV.NSSPATIILFHVTVLPK...................
A0A452C6X0_BALAS/71-158              .........................................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGNHSETLMSKGKEPTL...TKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK...................
A0A2Y9P1F7_DELLE/169-256             .........................................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGNNSETLMSKGKEPTL...TKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK...................
A0A383YZS1_BALAS/169-244             .........................................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YR------------GKEPTL...TKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK...................
A0A2K6ADS1_MANLE/168-255             .........................................RSVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGNNTETLVSKGKEPTL...TKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK...................
A0A3B1K9P2_ASTMX/111-192             ........................................h-ELKGQEGEQVVLDCFLSWHSLIIGQAEYHYs......wKRGARNELFEVLVVTEESKI...VLNQLSVSEQGVYRCLLLDK.H----------------gtelsrmi...........
A0A2Y9P6L9_DELLE/232-307             .........................................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YR------------GKEPTL...TKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK...................
M7B083_CHEMY/16-89                   .................yscnrdlrcgaclipvslrqvvgg-------------------------------........-------VEQVIVTGPDAFL...VKKEATVNDSGHYRCEMLNA.QGWVCSKLRFQVTVTP-l..................
A0A1S3G3D2_DIPOR/168-204             ........................................h-SVKVHEMEDIILDCHLNWHHASQGLADYSF........YRA-----------------...--------------------.-----------------svt................
A0A2U4APB7_TURTR/169-256             .........................................RKVKVHQMEDMILDCELNWHKLSQGLTDYSF........YRVWGKNSETLMSKGKEPTL...TKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK...................
G3VSG5_SARHA/195-279                 .......................................qy--VRVPKNGDMVLDCELSWHKAAEGLTYYHF........YRVWPNHSEVLISRGRDPAL...TKPMVSLEDAGDYRCILGTVrRRNPATVITYHV-----a..................
A0A2K5DEP7_AOTNA/168-255             .........................................RDVEVPRMEDMILDCELNWHKASEGLTDYSF........YRVWGNNTETLVSKGKEPTL...TKPMVGPEDAGDYRCELDTV.NSSPATIILFHVTVLPK...................
A0A3L8Q968_CHLGU/44-82               .........................................RQLWVEEGQDLVLDCALPWHGASHGAKTYSF........YRGL----------------...--------------------.-----------------aaag...............
G5BAH6_HETGA/168-255                 .........................................RNVEVHEMEDMILDCHLNWHQASQGLTDYSF........YRVWGNNSETLESKGKESLL...TKPLVGPEDAGDYRCELGTV.SYGPATIIYFHVTVLPK...................
A0A383YZK9_BALAS/169-256             .........................................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGNHSETLMSKGKEPTL...TKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK...................
A0A1S3AJR4_ERIEU/169-256             .........................................REIQVHAMEDLILDCELNWHQASQGLTDYSF........YRVWQNNTKTLVSRGKESTL...SKPMVDPKDAGTYLCELGTV.QSSPATIIHFHVKVLPK...................
F6YE25_HORSE/168-255                 .........................................RQVKVHRKEDMILDCELNWHRASEGLTDYSF........YRVWGKNDETLVSKGKEPTL...TKTMVGPEDQGTYRCELGTV.QSDPATIIYFHVTVLPQ...................
H0WN21_OTOGA/168-255                 .........................................RNVEVHEMEDMILDCELSWHRMSQGLSNYRF........YRVWGNKSETLVSDGKEPTL...TKPMVGAEDAGNYRCELGLV.KSSPATIIHFHVTVLPK...................
A0A3Q7VIE1_URSAR/168-256             .........................................REVTVHEMEDLRLNCELSWHRLSQGLANYNF........FRVWGTKAETLLYTGNDHTL...TKPAVTAEDAGVYRCSLDTV.RSGPATIIHFHVR----glllp..............
A0A2D0QYA3_ICTPU/207-284             .......................................hk--LVAHEGEQTVLDCFLPWHSLVFS------........----AKDEFEVLVVTKDSKI...VLNQLSVSEQGVYRCILLDQ.HGTTLSHTHFILTVIP-m..................
G3TPD8_LOXAF/168-255                 .........................................RQVEVQQMEDMILDCELNWHRASQGLTDYSF........YRVWENKTETLVSKGKEPTL...AKPMVGPEDAGTYRCELGTV.KKSPATIIHFRVKVLPR...................
A0A1A6G4T1_NEOLE/121-208             .........................................RRIEVPQLEDTVLDCQLSWHHASEGLTDYSF........YRVWGNSSETLLSKGKKPYL...TKTRVGPEDAGNYRCELGTI.NSGPATIIHFRVIVLPQ...................
A0A2U4APA6_TURTR/162-249             .........................................RKVKVHQMEDMILDCELNWHKLSQGLTDYSF........YRVWGKNSETLMSKGKEPTL...TKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK...................
A0A1S3NNR7_SALSA/185-280             .......................................yp--VEAAEGGQAVLDCFLPWHSLVVGQPDYHYtwapgtqrTANLTEGDFRVLVVTEDSSV...VLNQLHVDEEGMYRCLLTDG.KGTVLSRTHFLLTVTP-s..................
A0A2U4APB1_TURTR/169-256             .........................................RKVKVHQMEDMILDCELNWHKLSQGLTDYSF........YRVWGKNSETLMSKGKEPTL...TKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK...................
A0A1S3NNQ8_SALSA/160-255             .......................................yp--VEAAEGGQAVLDCFLPWHSLVVGQPDYHYtwapgtqrTANLTEGDFRVLVVTEDSSV...VLNQLHVDEEGMYRCLLTDG.KGTVLSRTHFLLTVTP-s..................
A0A287DEN9_ICTTR/162-249             ......................................rve---EIHEHEALNLNCFLDWHKEAVGLTNYVF........YRVWENNSETVLYSGKDPVF...NRPSASVNDSGKYRCELGTI.YNRPSTIIHFLVTVLPR...................
A0A2K6NEL4_RHIRO/168-255             .........................................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGNNTETLVSKGKEPTL...TKSMVGPEDAGRYRCELGSV.NSSPATVINFRVTVLPE...................
A0A2Y9P405_DELLE/232-319             .........................................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGNNSETLMSKGKEPTL...TKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK...................
A0A3Q7TNL9_URSAR/143-231             .........................................REVTVHEMEDLRLNCELSWHRLSQGLANYNF........FRVWGTKAETLLYTGNDHTL...TKPAVTAEDAGVYRCSLDTV.RSGPATIIHFHVR----glllp..............
A0A2R8QHQ6_DANRE/165-258             ........................................h-HLEADEGEEVVLDCFLSWHTLVVGQTEYHYswh..pgeTNVLFDGEYEELVVTKESKI...VLNQLSVSEEGSYRCLLKDQ.KGTALSRTFFQLEVKP-f..................
A0A3P8YQM3_ESOLU/95-188              ........................................q-DVTVSAGQHLDLDCLGEVM-EAMGRFSFRVsw....lyARGVVTTDDSLLRRWDAPSLarlVLDPVREEDAGTYRCDVQDI.AYRRVKRLYLGVKVLPR...................
A0A3Q7V496_URSAR/168-256             .........................................REVTVHEMEDLRLNCELSWHRLSQGLANYNF........FRVWGTKAETLLYTGNDHTL...TKPAVTAEDAGVYRCSLDTV.RSGPATIIHFHVR----glllp..............
A0A2D0QYZ5_ICTPU/207-300             .......................................hk--LVAHEGEQTVLDCFLPWHSLVVGHAKYQYswk..rgaTNFSAKDEFEVLVVTKDSKI...VLNQLSVSEQGVYRCILLDQ.HGTTLSHTHFILTVIP-m..................
A0A2U4APC4_TURTR/169-256             .........................................RKVKVHQMEDMILDCELNWHKLSQGLTDYSF........YRVWGKNSETLMSKGKEPTL...TKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK...................
A0A0A0MU86_PAPAN/168-255             .........................................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGNNTETLVSKGKEPTL...TKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK...................
A0A2Y9DWR9_TRIMA/168-255             .........................................RQVEVQQMQDMILDCELNWHRASQGLTDYSF........YRVWENKTETLVSKGKDPIL...AKPMVGPEDAGTYRCELGTV.NNSPATIIHFHVKVLPK...................
A0A2K6C510_MACNE/141-228             .........................................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGNNTETLVSKGKEPTL...TKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK...................
A0A1A6GNX2_NEOLE/157-244             .........................................RRVEVPQMEDMVLDCQLSWHHASEGLTDYSF........YRVWGNSSETLLSKGKEPYM...TKIMVSPEDAGNYRCELGTI.NSGPATIIHFRVIVLPK...................
A0A096LWR2_POEFO/164-257             .......................................hl--VQAEEGGQAVLNCFLPWHRFLLGKPEYHYsra..tdlYTQLTEKDFQPLVVTQDASI...VLNQLHLDEQGTYRCSLQDE.NGAVYYRASFQLTVKP-l..................
A0A2K5UGJ7_MACFA/168-255             .........................................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGNNTETLVSKGKEPTL...TKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK...................
A0A2Y9EZU1_PHYMC/169-256             .........................................RQVKVHQMEDMILDCELNWHKVSQGLTDYSF........YRVWGNNSETLMSKGKEPTL...TKTMVRPKDAGTYRCELGSV.RSSPATIIYFHVTVLPK...................
F7H859_CALJA/168-255                 .........................................RDVEVPHMEDMTLDCELNWHKASEGLTDYSF........YRVWGNNTETLVSKGKESTL...TKPMVGPEDAGDYRCELGTV.NSSPATIILFHVTVLPK...................
H2QGS4_PANTR/168-255                 .........................................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGNNTETLVSKGKEATL...TKPMVGPEDAGSYRCELGSV.NSSPATIINFHVTVLPR...................
A0A2U4APA9_TURTR/133-220             .........................................RKVKVHQMEDMILDCELNWHKLSQGLTDYSF........YRVWGKNSETLMSKGKEPTL...TKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK...................
G1P6T7_MYOLU/171-258                 .........................................RRVNVHEMEDMILDCELNWHHISEGLTDYTF........YRVWKNKPESMVYKGTAPTL...TKTKANPSDAGTYRCQLNTV.KNSPATIIRYHVRVLPK...................
A0A3B3XUR9_9TELE/77-166              .....................................ktmt----VTSGQRVEIDCLGEV-MAAMGAVLWRY........ARGVITSDDSLFDRWKAPDLqrvVLDPVREKDAGTYRCDVQDA.NYRRKKTVYWGVRVLP-a..................
A0A498MAL9_LABRO/133-183             .........................................RHVEADEGEEVVLDCFLPWHALVVGQTEYHY........S-------------------...--------------------.-----------------whpreknvhahrqtntfsa
F6UM65_CANLF/166-252                 .........................................HEVVVHELEDLVLDCELSWHRISAGLNNYTF........YRVLGSNS-LLLSVGKEPTL...TKTMVRLEDAGTYRCELANM.KTSRAAVTHFRVRVLPQ...................
A0A2U3YV44_LEPWE/168-255             .......................................rl--VIVHEMEDLILNCELSWHRLSQGLTDYSF........FRVWGKDSETLLSKGKNSTL...IKTAVTAEDAGVYRCSLDSV.RSIPATIIFYQVKVLP-g..................
A0A383YZJ5_BALAS/140-227             .........................................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGNHSETLMSKGKEPTL...TKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK...................
#=GC SS_cons                         .........................................EEEEEETTS-EEEE---GGGGCSCSEEEEEE........EEE-TTS-EEEEEEES-SEE...EESS--GGG-EEEEEEEEES.SSSECEEEEEEEEEEST-..................
#=GC seq_cons                        .........................................RpVcVcpMEDhILDCELsWH+hSpGLTDYSF........YRVWGssoETLlS+GKEPoL...TKshVpscDAGsYRCELuoV.pSoPATIIaF+VTVLPp...................
//
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