GenomeNet

Database: Pfam
Entry: Izumo-Ig
LinkDB: Izumo-Ig
Original site: Izumo-Ig 
#=GF ID   Izumo-Ig
#=GF AC   PF16706.5
#=GF DE   Izumo-like Immunoglobulin domain
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   [1]
#=GF GA   26.70 26.70;
#=GF TC   26.70 26.80;
#=GF NC   26.60 26.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Immunoglobulin_superfamily
#=GF RN   [1]
#=GF RM   16574441
#=GF RT   The molecular players of sperm-egg fusion in mammals.
#=GF RA   Rubinstein E, Ziyyat A, Wolf JP, Le Naour F, Boucheix C;
#=GF RL   Semin Cell Dev Biol. 2006;17:254-263.
#=GF RN   [2]
#=GF RM   15759005
#=GF RT   The immunoglobulin superfamily protein Izumo is required for
#=GF RT   sperm to fuse with eggs.
#=GF RA   Inoue N, Ikawa M, Isotani A, Okabe M;
#=GF RL   Nature. 2005;434:234-238.
#=GF DR   INTERPRO; IPR032699;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Izumo-Ig is the immunoglobulin domain on Izumo proteins from
#=GF CC   higher eukaryotes. Izumo is a typical type I membrane
#=GF CC   glycoprotein with one immunoglobulin-like domain and a putative
#=GF CC   N-glycoside link motif - glycosylation site. The full-length
#=GF CC   protein, eg Swiss:Q8IYV9, is a molecule with a single
#=GF CC   immunoglobulin (Ig) domain. It is thought that Izumo proteins
#=GF CC   bind to putative Izumo receptors on the oocyte.  Izumo is not
#=GF CC   detectable on the surface of fresh sperm but becomes exposed
#=GF CC   only after an exocytotic process, the acrosome reaction, has
#=GF CC   occurred. Studies have shown that knock-out mice (Izumo-/-
#=GF CC   males) were sterile despite normal mating behaviour and
#=GF CC   ejaculation, indicating the importance of the protein in
#=GF CC   fertilisation [1]. There is a conserved GCL sequence motif.
#=GF CC   Izumo expression has been found to be testis-specific [1,2].
#=GF SQ   61
#=GS IZUM1_RAT/168-255         AC Q6AY06.1
#=GS A0A287CWI4_ICTTR/169-256  AC A0A287CWI4.1
#=GS W5PRD0_SHEEP/169-256      AC W5PRD0.1
#=GS V8PHR1_OPHHA/159-245      AC V8PHR1.1
#=GS A0A1S3G4U8_DIPOR/168-202  AC A0A1S3G4U8.1
#=GS G1TVX5_RABIT/168-255      AC G1TVX5.1
#=GS A0A091D708_FUKDA/184-271  AC A0A091D708.1
#=GS G1QXF7_NOMLE/168-255      AC G1QXF7.1
#=GS M3XLJ0_LATCH/158-246      AC M3XLJ0.1
#=GS L5L4K5_PTEAL/134-221      AC L5L4K5.1
#=GS F6YE25_HORSE/168-255      AC F6YE25.1
#=GS A0A2I4AR79_9TELE/133-226  AC A0A2I4AR79.1
#=GS IZUM1_HUMAN/168-255       AC Q8IYV9.2
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JKE C; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5F4V A; 168-255;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5F4T A; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5F4E A; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JK9 D; 168-250;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JK9 C; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JK9 B; 168-255;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JKC A; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JK9 F; 168-255;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JKD A; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JK9 E; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JK9 A; 168-255;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JKE A; 168-254;
#=GS M7B083_CHEMY/16-89        AC M7B083.1
#=GS A0A2I2UXT7_FELCA/264-351  AC A0A2I2UXT7.1
#=GS F7H859_CALJA/168-255      AC F7H859.1
#=GS A0A1S3G3D2_DIPOR/168-204  AC A0A1S3G3D2.1
#=GS G3VSG5_SARHA/195-279      AC G3VSG5.1
#=GS A0A1S3G3S8_DIPOR/168-208  AC A0A1S3G3S8.1
#=GS F6Y5G2_ORNAN/153-214      AC F6Y5G2.2
#=GS G5BAH6_HETGA/168-255      AC G5BAH6.1
#=GS A0A1S3AJR4_ERIEU/169-256  AC A0A1S3AJR4.1
#=GS H9H653_MONDO/205-293      AC H9H653.2
#=GS A0A2D0QWP8_ICTPU/207-300  AC A0A2D0QWP8.1
#=GS G1M882_AILME/167-254      AC G1M882.1
#=GS H0WN21_OTOGA/168-255      AC H0WN21.1
#=GS G3QFY5_GORGO/168-255      AC G3QFY5.2
#=GS S9YYW1_CAMFR/162-249      AC S9YYW1.1
#=GS A0A2K5ICP7_COLAP/168-255  AC A0A2K5ICP7.1
#=GS E1BDA8_BOVIN/174-261      AC E1BDA8.2
#=GS A0A0D9S2Z4_CHLSB/170-257  AC A0A0D9S2Z4.1
#=GS W5KQV6_ASTMX/165-258      AC W5KQV6.1
#=GS A0A2D0QYA3_ICTPU/207-284  AC A0A2D0QYA3.1
#=GS A0A1U7QS27_MESAU/168-255  AC A0A1U7QS27.1
#=GS A0A2K5MSM3_CERAT/168-255  AC A0A2K5MSM3.1
#=GS G3TPD8_LOXAF/168-255      AC G3TPD8.1
#=GS A0A1A6G4T1_NEOLE/121-208  AC A0A1A6G4T1.1
#=GS L5LHN8_MYODS/162-249      AC L5LHN8.1
#=GS F6XH82_MACMU/168-255      AC F6XH82.1
#=GS A0A1S3NNQ8_SALSA/160-255  AC A0A1S3NNQ8.1
#=GS A0A1S3NNR7_SALSA/185-280  AC A0A1S3NNR7.1
#=GS A0A287DEN9_ICTTR/162-249  AC A0A287DEN9.1
#=GS K7DZS4_MONDO/205-254      AC K7DZS4.1
#=GS A0A2D0QYZ5_ICTPU/207-300  AC A0A2D0QYZ5.1
#=GS A0A0A0MU86_PAPAN/168-255  AC A0A0A0MU86.2
#=GS IZUM1_MOUSE/168-255       AC Q9D9J7.1
#=GS IZUM1_MOUSE/168-255       DR PDB; 5B5K A; 168-255;
#=GS A0A1S3NNW2_SALSA/125-220  AC A0A1S3NNW2.1
#=GS L9J9G8_TUPCH/134-218      AC L9J9G8.1
#=GS S7PYD7_MYOBR/162-249      AC S7PYD7.1
#=GS A0A1A6GNX2_NEOLE/157-244  AC A0A1A6GNX2.1
#=GS A0A096LWR2_POEFO/164-257  AC A0A096LWR2.1
#=GS F1RIQ7_PIG/171-258        AC F1RIQ7.2
#=GS A0A087Y4Y6_POEFO/90-183   AC A0A087Y4Y6.2
#=GS A0A2D0QWQ3_ICTPU/187-280  AC A0A2D0QWQ3.1
#=GS H3DD44_TETNG/56-151       AC H3DD44.1
#=GS H2QGS4_PANTR/168-255      AC H2QGS4.1
#=GS G7PY44_MACFA/168-255      AC G7PY44.1
#=GS G1P6T7_MYOLU/171-258      AC G1P6T7.1
#=GS G3HZX1_CRIGR/395-482      AC G3HZX1.1
#=GS A0A1U7T080_TARSY/168-255  AC A0A1U7T080.1
#=GS F6UM65_CANLF/166-252      AC F6UM65.1
IZUM1_RAT/168-255                    ...............................RQIEVHRLEDMVLDCQLSWHHASEGLTDYSF........YRVWGNSSETLMSKGKEPYL...TKTMVGPEDAGNYRCELDTV.NAGPATIIYYHVTVLPP...
A0A287CWI4_ICTTR/169-256             ............................rve---EIHEHEALNLNCFLDWHKEAVGLTNYVF........YRVWENNSETVLYSGKDPVF...NRPSASVNDSGKYRCELGTI.YNRPSTIIHFLVTVLPR...
W5PRD0_SHEEP/169-256                 ...............................REVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWKNNSETLVSRGKEPIL...TKTMVRPKDAGTYRCELGSI.QSSPATIIYFHVTVLPK...
V8PHR1_OPHHA/159-245                 ...............................RKVHVEIDEDLILDCALKWHKASHGVKTYRF........YRMV-NNKEKLMASGADSFL...TKKEVNMKDAGRYRCKMVDT.KGYTSSQLDFQVVVLPP...
A0A1S3G4U8_DIPOR/168-202             ..............................h-SVKVHEMEDIILDCHLNWHHASQGLADYSF........YR------------------...--------------------.-----------------gp.
G1TVX5_RABIT/168-255                 ............................hrs---EVHQMDDLILDCKLSWHQASQGLTDYSF........YRVWGNNSETLMAKGKAHLL...TKPLVGPEDAGTYRCELGTV.SSGPATIMRFQVTVLPP...
A0A091D708_FUKDA/184-271             ...............................RSVEVHQMEDMILDCHLNWHQASQGLTDYSF........YRVWGNNSETLVSKGKESLL...TKPLVGPEDAGDYLCELGTV.SYGPATIINFHVTVLPE...
G1QXF7_NOMLE/168-255                 ...............................RNVEVPQMEDMMLDCELNWHQASEGLTDYSF........YRVWGNNTETLVSKGKEATL...TKPMVGPEDAGSYRCELGSV.NSSPATIINFHVTVLPK...
M3XLJ0_LATCH/158-246                 ...............................RNISVSEFDSLRLDCSEPWHFKVQNKGLFTFn......vDLAEAGSPRTYLFASESPYL...VINGITLEHQGTYHCQLTDR.DGDIVSEKRFEVNV---hs.
L5L4K5_PTEAL/134-221                 ...............................REVTVHAMEDMILDCELNWHHASEGLTDYSF........FRVWTNKSETLVSKGKEPTL...TKTMVDSKDAGTYRCQLDTV.QSSPATIIYFNVSVLPK...
F6YE25_HORSE/168-255                 ...............................RQVKVHRKEDMILDCELNWHRASEGLTDYSF........YRVWGKNDETLVSKGKEPTL...TKTMVGPEDQGTYRCELGTV.QSDPATIIYFHVTVLPQ...
A0A2I4AR79_9TELE/133-226             ..............................p--VEAEEGGQAVLNCFVSWHRLLLGNPEYYYswa.petgNKELDEKDFTALVVTEDSFV...VLNQLHLDEQGTYQCSLRDQ.NGTVFYRVTFLLSVAP-l..
IZUM1_HUMAN/168-255                  ...............................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGNNTETLVSKGKEATL...TKPMVGPEDAGSYRCELGSV.NSSPATIINFHVTVLPK...
#=GR IZUM1_HUMAN/168-255       SS    ...............................EEEEEETTS-EEEE---GGGGGSCSEEEEEE........EEE-TTS-EEEEEEES-SEE...EESS--GGG-EEEEEEEEES.SSSESEEEEEEEEEEST...
M7B083_CHEMY/16-89                   ........yscnrdlrcgaclipvslrqvvg-------------------------------........------GVEQVIVTGPDAFL...VKKEATVNDSGHYRCEMLNA.QGWVCSKLRFQVTVTP-l..
A0A2I2UXT7_FELCA/264-351             ...............................RQINVHETEDLVLDCELDWHKIATGATGYSF........YRVWGSKADSLLYTGKWPTL...TKQLVRPADAGTYRCALGTP.GVSLFSALRFEVTVLPR...
F7H859_CALJA/168-255                 ...............................RDVEVPHMEDMTLDCELNWHKASEGLTDYSF........YRVWGNNTETLVSKGKESTL...TKPMVGPEDAGDYRCELGTV.NSSPATIILFHVTVLPK...
A0A1S3G3D2_DIPOR/168-204             ..............................h-SVKVHEMEDIILDCHLNWHHASQGLADYSF........YRA-----------------...--------------------.-----------------svt
G3VSG5_SARHA/195-279                 .............................qy--VRVPKNGDMVLDCELSWHKAAEGLTYYHF........YRVWPNHSEVLISRGRDPAL...TKPMVSLEDAGDYRCILGTVrRRNPATVITYHV-----a..
A0A1S3G3S8_DIPOR/168-208             ..............................h-SVKVHEMEDIILDCHLNWHHASQGLADYSF........YRVGSCN-------------...--------------------.-----------------ssk
F6Y5G2_ORNAN/153-214                 ............................lpp-----------------------------TF........VGVWANRTEQLLARSPDPFL...RRPLVTLEDAGTYRCTLDTA.SHEVATEMRYQVTVTP-t..
G5BAH6_HETGA/168-255                 ...............................RNVEVHEMEDMILDCHLNWHQASQGLTDYSF........YRVWGNNSETLESKGKESLL...TKPLVGPEDAGDYRCELGTV.SYGPATIIYFHVTVLPK...
A0A1S3AJR4_ERIEU/169-256             ...............................REIQVHAMEDLILDCELNWHQASQGLTDYSF........YRVWQNNTKTLVSRGKESTL...SKPMVDPKDAGTYLCELGTV.QSSPATIIHFHVKVLPK...
H9H653_MONDO/205-293                 ..............................q-AVQVIEKGDLILDCELSWHKKAEGLTTYSF........FKILTNGTEVLLSRGKDSAL...TKPMVAFEDGGSYRCILDTIrKHSPATIIVYRVQVIPD...
A0A2D0QWP8_ICTPU/207-300             ..............................h-KLVAHEGEQTVLDCFLPWHSLVVGHAKYQYswk..rgaTNFSAKDEFEVLVVTKDSKI...VLNQLSVSEQGVYRCILLDQ.HGTTLSHTHFILTVIP-m..
G1M882_AILME/167-254                 ...............................REITVHEMEDLRLNCELSWHRLSQGLASYNF........FRVWGTKSETLLYTGNDHTL...TKPAVTAEDAGVYRCSLDTV.SSGPATIIHYHVRVLPR...
H0WN21_OTOGA/168-255                 ...............................RNVEVHEMEDMILDCELSWHRMSQGLSNYRF........YRVWGNKSETLVSDGKEPTL...TKPMVGAEDAGNYRCELGLV.KSSPATIIHFHVTVLPK...
G3QFY5_GORGO/168-255                 ...............................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGNNTETLVSKGKEATL...TKPMVGPEDAGSYRCELGSV.NSSPATIINFHVRVLPK...
S9YYW1_CAMFR/162-249                 ...............................RKVEVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGNNSETLMSKGIQPTL...TKIMVSPEDAGIYRCELGSV.KSSPATIIHFRVTVLPK...
A0A2K5ICP7_COLAP/168-255             ...............................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGNNTETLVSKGKEPTL...TKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK...
E1BDA8_BOVIN/174-261                 ...............................REVKVHHMEDMILDCELNWHKISQGLTDYSF........YRVWKNNSETLVSKGKEPIL...TKTMVRPKDAGTYRCELGSI.QSSPATIIYFHVTVLPK...
A0A0D9S2Z4_CHLSB/170-257             ...............................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGNNTETLVSKGKEPTL...TKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK...
W5KQV6_ASTMX/165-258                 .............................he--LKGQEGEQVVLDCFLSWHSLIIGQAEYHYswk..rgaRNFSDQELFEVLVVTEESKI...VLNQLSVSEQGVYRCLLLDK.HGTELSRMHFILNIIP-s..
A0A2D0QYA3_ICTPU/207-284             ..............................h-KLVAHEGEQTVLDCFLPWHSLVFS------........----AKDEFEVLVVTKDSKI...VLNQLSVSEQGVYRCILLDQ.HGTTLSHTHFILTVIP-m..
A0A1U7QS27_MESAU/168-255             ...............................RRIEVHRLEDLVLDCQLSWHHASEGLTDYSF........YRVWGNSSETLLSKGKEPYM...TKSMVGPEDAGNYRCELGTV.NAGPATIIHFRVIVLPQ...
A0A2K5MSM3_CERAT/168-255             ...............................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGNNTETLVSKGKEPIL...TKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK...
G3TPD8_LOXAF/168-255                 ...............................RQVEVQQMEDMILDCELNWHRASQGLTDYSF........YRVWENKTETLVSKGKEPTL...AKPMVGPEDAGTYRCELGTV.KKSPATIIHFRVKVLPR...
A0A1A6G4T1_NEOLE/121-208             ...............................RRIEVPQLEDTVLDCQLSWHHASEGLTDYSF........YRVWGNSSETLLSKGKKPYL...TKTRVGPEDAGNYRCELGTI.NSGPATIIHFRVIVLPQ...
L5LHN8_MYODS/162-249                 ...............................RRVNVHEMEDMILDCELNWHHISEGLTDYTF........YRVWKNKSESMVYKGTAPTL...TKARAKPSDAGTYRCQLNTV.KNSPATIIRYHVRVLPK...
F6XH82_MACMU/168-255                 ...............................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGNNTETLVSKGKEPTL...TKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK...
A0A1S3NNQ8_SALSA/160-255             .............................yp--VEAAEGGQAVLDCFLPWHSLVVGQPDYHYtwapgtqrTANLTEGDFRVLVVTEDSSV...VLNQLHVDEEGMYRCLLTDG.KGTVLSRTHFLLTVTP-s..
A0A1S3NNR7_SALSA/185-280             .............................yp--VEAAEGGQAVLDCFLPWHSLVVGQPDYHYtwapgtqrTANLTEGDFRVLVVTEDSSV...VLNQLHVDEEGMYRCLLTDG.KGTVLSRTHFLLTVTP-s..
A0A287DEN9_ICTTR/162-249             ............................rve---EIHEHEALNLNCFLDWHKEAVGLTNYVF........YRVWENNSETVLYSGKDPVF...NRPSASVNDSGKYRCELGTI.YNRPSTIIHFLVTVLPR...
K7DZS4_MONDO/205-254                 ..............................q-AVQVIEKGDLILDCELSWHKKSEGLTDYSF........YKILTNGTEVLLSQGQ----...--------------------.-----------------gfg
A0A2D0QYZ5_ICTPU/207-300             ..............................h-KLVAHEGEQTVLDCFLPWHSLVVGHAKYQYswk..rgaTNFSAKDEFEVLVVTKDSKI...VLNQLSVSEQGVYRCILLDQ.HGTTLSHTHFILTVIP-m..
A0A0A0MU86_PAPAN/168-255             ...............................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGNNTETLVSKGKEPTL...TKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK...
IZUM1_MOUSE/168-255                  ...............................RHIEVHRSEDLVLDCLLSWHRASKGLTDYSF........YRVWENSSETLIAKGKEPYL...TKSMVGPEDAGNYRCVLDTI.NQGHATVIRYDVTVLPP...
#=GR IZUM1_MOUSE/168-255       SS    ...............................EEEEEETTS-EEEE---GGGGT-SSEEEEEE........EEE-TTS-EEEEEEES-SEE...EE-S--GGG-EEEEEEEEES.SS-EEEEEEEEEEEE--...
A0A1S3NNW2_SALSA/125-220             .............................yp--VEAAEGGQAVLDCFLPWHSLVVGQPDYHYtwapgtqrTANLTEGDFRVLVVTEDSSV...VLNQLHVDEEGMYRCLLTDG.KGTVLSRTHFLLTVTP-s..
L9J9G8_TUPCH/134-218                 ...............................RQVEVYEMEDLILDCELNWHHASQGLTEYSF........YRVWANDSETLVSRKKEPTL...TKPMVGPEDEGNYRCELGTV.NSGPATIIYFHVT----g..
S7PYD7_MYOBR/162-249                 ...............................RRVNVHEMEDMILDCELNWHHISEGLTDYTF........YRVWKNKPESMVYKGTAPTL...TKTKATPSDAGTYRCQLNTV.NNSPATIIRYHVRVLPK...
A0A1A6GNX2_NEOLE/157-244             ...............................RRVEVPQMEDMVLDCQLSWHHASEGLTDYSF........YRVWGNSSETLLSKGKEPYM...TKIMVSPEDAGNYRCELGTI.NSGPATIIHFRVIVLPK...
A0A096LWR2_POEFO/164-257             .............................hl--VQAEEGGQAVLNCFLPWHRFLLGKPEYHYsra..tdlYTQLTEKDFQPLVVTQDASI...VLNQLHLDEQGTYRCSLQDE.NGAVYYRASFQLTVKP-l..
F1RIQ7_PIG/171-258                   ...............................RKVKVHQMEDMILDCELNWHKVSQGLTDYSF........YRVWKNNSETLMAKGQEPTL...TKTMVSPKDAGTYRCELGTV.QSTPATIIHFHVTVLPK...
A0A087Y4Y6_POEFO/90-183              ktmtvtsgqrveidclgevmaamgafswrvs----------------------------WRY........ARGVITSDDSLFDRWKAPDLqrvVLDPVREKDAGTYRCDVQDA.NYRRKKTVYWGVRVLP-a..
A0A2D0QWQ3_ICTPU/187-280             ..............................h-KLVAHEGEQTVLDCFLPWHSLVVGHAKYQYswk..rgaTNFSAKDEFEVLVVTKDSKI...VLNQLSVSEQGVYRCILLDQ.HGTTLSHTHFILTVIP-m..
H3DD44_TETNG/56-151                  ..............................n-TVQAEEGGQAVLDCLQPWHHLLMGRPEYHFswapgvpgTKTVNESNFIVLVVTEDSSL...VLNQLRLDEQGTYRCSLQDQ.NETVFYQVHFLLTVAP-l..
H2QGS4_PANTR/168-255                 ...............................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGNNTETLVSKGKEATL...TKPMVGPEDAGSYRCELGSV.NSSPATIINFHVTVLPR...
G7PY44_MACFA/168-255                 ...............................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGNNTETLVSKGKEPTL...TKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK...
G1P6T7_MYOLU/171-258                 ...............................RRVNVHEMEDMILDCELNWHHISEGLTDYTF........YRVWKNKPESMVYKGTAPTL...TKTKANPSDAGTYRCQLNTV.KNSPATIIRYHVRVLPK...
G3HZX1_CRIGR/395-482                 ...............................RRIEVHRMEDMVLDCQLSWHHASEGLTEYSF........YKVWGNSSETLMSKGREPYM...TKTMVGPEDAGNYRCELGTI.NAGPATIIHFRVIVL--ga.
A0A1U7T080_TARSY/168-255             ...............................RRVKVHQMEDMILDCEFNWHRASEGLTDYSF........YRVWGNHSETLVSKGKEPTL...TKPMVGQEDAGSYRCELGTV.TSEPGLLFDPSLPVLPK...
F6UM65_CANLF/166-252                 ..............................h-EVVVHELEDLVLDCELSWHRISAGLNNYTF........YRVLGSNS-LLLSVGKEPTL...TKTMVRLEDAGTYRCELANM.KTSRAAVTHFRVRVLPQ...
#=GC SS_cons                         ...............................EEEEEETTS-EEEE---GGGGCSCSEEEEEE........EEE-TTS-EEEEEEES-SEE...EESS--GGG-EEEEEEEEES.SSSECEEEEEEEEEEST...
#=GC seq_cons                        ...............................RpVcVpphEDhlLDCcLsWHphSpGLTDYoF........YRVWsNsoEoLlu+GK-stL...TKshVss-DAGsYRCpLsol.pusPATlIpFcVoVLP....
//
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